psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	10.73	Yes	Yes	2	0	0
2	L:L:Y1	R:R:M153	7.18	Yes	No	0	0	7
3	L:L:Y1	R:R:V238	3.79	Yes	No	0	0	5
4	L:L:Y1	R:R:I298	3.63	Yes	No	2	0	6
5	L:L:Y1	R:R:H299	14.16	Yes	Yes	0	0	7
6	L:L:Y1	R:R:V302	6.31	Yes	No	0	0	5
7	L:L:?2	L:L:G3	6.96	Yes	No	2	0	0
8	L:L:?2	R:R:I298	5.81	Yes	No	2	0	6
9	L:L:?2	R:R:W320	5.79	Yes	Yes	2	0	4
10	L:L:?2	R:R:I324	7.26	Yes	No	0	0	5
11	L:L:?4	L:L:G3	10.36	Yes	No	2	0	0
12	L:L:G3	R:R:Q126	3.29	No	Yes	2	0	6
13	L:L:?4	L:L:?5	27.45	Yes	No	0	0	0
14	L:L:?4	R:R:Q126	9.21	Yes	Yes	2	0	6
15	L:L:?4	R:R:N129	3.56	Yes	No	0	0	4
16	L:L:?4	R:R:V145	3.87	Yes	Yes	2	0	5
17	R:R:T69	R:R:V318	4.76	No	No	0	4	1
18	R:R:I73	R:R:Y130	3.63	No	Yes	4	6	5
19	R:R:H321	R:R:I73	21.21	No	No	4	4	6
20	R:R:M74	R:R:S127	6.13	No	No	0	5	6
21	R:R:L131	R:R:M74	4.24	No	No	0	4	5
22	R:R:A325	R:R:L76	3.15	No	No	0	6	5
23	R:R:H321	R:R:Y77	13.07	No	No	0	4	7
24	R:R:I324	R:R:Y77	9.67	No	No	0	5	7
25	R:R:C81	R:R:L85	3.17	No	No	0	6	6
26	R:R:C81	R:R:L123	4.76	No	No	0	6	7
27	R:R:C81	R:R:P124	3.77	No	No	0	6	8
28	R:R:C332	R:R:V83	3.42	No	No	0	8	5
29	R:R:C332	R:R:G84	3.92	No	No	0	8	8
30	R:R:L85	R:R:T120	4.42	No	No	0	6	5
31	R:R:F86	R:R:L90	7.31	No	No	0	5	6
32	R:R:D116	R:R:N88	4.04	Yes	Yes	1	9	9
33	R:R:A117	R:R:N88	4.69	No	Yes	0	7	9
34	R:R:N88	R:R:T120	2.92	Yes	No	0	9	5
35	R:R:N88	R:R:P335	6.52	Yes	No	1	9	9
36	R:R:I95	R:R:V91	3.07	Yes	Yes	0	7	9
37	R:R:A113	R:R:V91	3.39	No	Yes	0	9	9
38	R:R:A339	R:R:V91	3.39	No	Yes	0	6	9
39	R:R:F110	R:R:M92	6.22	No	No	0	6	7
40	R:R:L114	R:R:M92	2.83	No	No	0	7	7
41	R:R:R97	R:R:Y93	7.2	No	No	0	5	4
42	R:R:V94	R:R:Y98	5.05	No	No	0	7	4
43	R:R:I95	R:R:M101	2.92	Yes	No	5	7	7
44	R:R:I109	R:R:I95	2.94	No	Yes	0	8	7
45	R:R:F110	R:R:I95	3.77	No	Yes	5	6	7
46	R:R:N106	R:R:T99	8.77	No	No	0	8	6
47	R:R:I107	R:R:M101	4.37	No	No	0	5	7
48	R:R:F110	R:R:M101	8.71	No	No	5	6	7
49	R:R:N106	R:R:T103	8.77	No	No	0	8	7
50	R:R:I109	R:R:T105	3.04	No	No	0	8	8
51	R:R:T162	R:R:Y108	6.24	No	Yes	6	7	7
52	R:R:M163	R:R:Y108	5.99	No	Yes	0	9	7
53	R:R:D166	R:R:Y108	5.75	No	Yes	0	8	7
54	R:R:A186	R:R:Y108	4	No	Yes	0	7	7
55	R:R:I189	R:R:Y108	3.63	No	Yes	6	5	7
56	R:R:N111	R:R:T159	10.24	Yes	No	1	9	8
57	R:R:N111	R:R:N190	16.35	Yes	No	1	9	7
58	R:R:N111	R:R:N193	5.45	Yes	No	1	9	7
59	R:R:N111	R:R:W194	11.3	Yes	Yes	1	9	9
60	R:R:D116	R:R:L112	9.5	Yes	Yes	1	9	9
61	R:R:L112	R:R:S156	3	Yes	No	1	9	9
62	R:R:L112	R:R:T159	2.95	Yes	No	1	9	8
63	R:R:L112	R:R:L160	5.54	Yes	No	1	9	8
64	R:R:L112	R:R:N334	4.12	Yes	Yes	1	9	9
65	R:R:L112	R:R:Y338	3.52	Yes	Yes	1	9	9
66	R:R:L114	R:R:L118	4.15	No	No	0	7	7
67	R:R:L114	R:R:W194	5.69	No	Yes	0	7	9
68	R:R:A115	R:R:T155	3.36	No	Yes	0	8	7
69	R:R:D116	R:R:S156	5.89	Yes	No	1	9	9
70	R:R:D116	R:R:S331	5.89	Yes	No	0	9	9
71	R:R:D116	R:R:P335	4.83	Yes	No	1	9	9
72	R:R:L118	R:R:N152	12.36	No	Yes	0	7	8
73	R:R:I148	R:R:T122	3.04	No	No	0	5	6
74	R:R:D149	R:R:T122	5.78	No	No	0	5	6
75	R:R:L123	R:R:Y328	16.41	No	No	0	7	7
76	R:R:F125	R:R:W135	4.01	No	Yes	2	6	8
77	R:R:F125	R:R:F137	4.29	No	No	2	6	6
78	R:R:F125	R:R:V145	6.55	No	Yes	2	6	5
79	R:R:I324	R:R:Q126	6.86	No	Yes	0	5	6
80	R:R:Q126	R:R:Y328	6.76	Yes	No	0	6	7
81	R:R:L131	R:R:Y130	3.52	No	Yes	0	4	5
82	R:R:T317	R:R:Y130	3.75	No	Yes	0	4	5
83	R:R:H321	R:R:Y130	13.07	No	Yes	4	4	5
84	R:R:M132	R:R:T134	3.01	Yes	Yes	3	4	5
85	R:R:M132	R:R:P136	3.35	Yes	No	3	4	3
86	R:R:P136	R:R:T134	3.5	No	Yes	3	3	5
87	R:R:I217	R:R:T134	7.6	No	Yes	0	4	5
88	R:R:F137	R:R:W135	18.04	No	Yes	2	6	8
89	R:R:C142	R:R:W135	3.92	No	Yes	2	9	8
90	R:R:V145	R:R:W135	4.9	Yes	Yes	2	5	8
91	R:R:C219	R:R:W135	9.14	No	Yes	2	9	8
92	R:R:F137	R:R:L141	6.09	No	No	0	6	5
93	R:R:K143	R:R:T139	3	No	No	0	6	3
94	R:R:T139	R:R:T210	6.28	No	No	0	3	4
95	R:R:L141	R:R:V145	2.98	No	Yes	0	5	5
96	R:R:C142	R:R:T210	3.38	No	No	0	9	4
97	R:R:C142	R:R:C219	7.28	No	No	2	9	9
98	R:R:A208	R:R:K143	3.21	No	No	0	5	6
99	R:R:I144	R:R:I148	2.94	No	No	0	5	5
100	R:R:A208	R:R:I146	4.87	No	No	0	5	4
101	R:R:C219	R:R:I146	3.27	No	No	0	9	4
102	R:R:M205	R:R:S147	9.2	No	No	0	5	6
103	R:R:I148	R:R:N152	5.66	No	Yes	0	5	8
104	R:R:D149	R:R:Y328	5.75	No	No	0	5	7
105	R:R:V204	R:R:Y150	3.79	No	No	0	5	4
106	R:R:N152	R:R:Y151	4.65	Yes	Yes	0	8	5
107	R:R:T155	R:R:Y151	3.75	Yes	Yes	1	7	5
108	R:R:W194	R:R:Y151	8.68	Yes	Yes	1	9	5
109	R:R:S197	R:R:Y151	7.63	No	Yes	1	8	5
110	R:R:I157	R:R:M153	2.92	No	No	0	7	7
111	R:R:M153	R:R:W295	6.98	No	Yes	0	7	8
112	R:R:F154	R:R:F158	3.22	No	No	0	6	5
113	R:R:F154	R:R:I200	5.02	No	No	0	6	5
114	R:R:F154	R:R:V238	6.55	No	No	0	6	5
115	R:R:T155	R:R:W194	10.92	Yes	Yes	1	7	9
116	R:R:S197	R:R:T155	6.4	No	Yes	1	8	7
117	R:R:I157	R:R:P246	3.39	No	Yes	0	7	8
118	R:R:F158	R:R:N193	4.83	No	No	0	5	7
119	R:R:F158	R:R:L196	3.65	No	No	0	5	4
120	R:R:N193	R:R:T159	7.31	No	No	1	7	8
121	R:R:L160	R:R:N334	6.87	No	Yes	1	8	9
122	R:R:L160	R:R:Y338	4.69	No	Yes	1	8	9
123	R:R:C161	R:R:P246	3.77	No	Yes	0	7	8
124	R:R:I189	R:R:T162	3.04	No	No	6	5	7
125	R:R:M163	R:R:Y338	4.79	No	Yes	0	9	9
126	R:R:I250	R:R:S164	7.74	No	No	0	8	9
127	R:R:C253	R:R:S164	3.44	No	No	0	8	9
128	R:R:S164	R:R:Y254	10.17	No	Yes	0	9	9
129	R:R:D166	R:R:R181	8.34	No	No	0	8	7
130	R:R:R167	R:R:Y338	3.09	No	Yes	0	9	9
131	R:R:C172	R:R:Y168	8.06	No	Yes	0	7	8
132	R:R:H173	R:R:Y168	5.44	No	Yes	0	6	8
133	R:R:C253	R:R:Y168	9.41	No	Yes	0	8	8
134	R:R:L256	R:R:Y168	7.03	No	Yes	0	5	8
135	R:R:A170	R:R:R181	4.15	No	No	0	8	7
136	R:R:M257	R:R:V171	7.61	No	No	0	8	8
137	R:R:L261	R:R:V171	2.98	No	No	0	8	8
138	R:R:C172	R:R:R260	4.18	No	No	0	7	5
139	R:R:P174	R:R:R260	2.88	No	No	0	8	5
140	R:R:F180	R:R:K176	8.69	No	No	0	3	4
141	R:R:P183	R:R:T182	3.5	No	No	0	1	7
142	R:R:N185	R:R:T182	4.39	No	No	0	4	7
143	R:R:N185	R:R:R184	3.62	No	No	0	4	3
144	R:R:I188	R:R:N185	2.83	No	No	0	3	4
145	R:R:N190	R:R:W194	7.91	No	Yes	1	7	9
146	R:R:L202	R:R:P203	3.28	No	No	0	4	8
147	R:R:L221	R:R:M207	5.65	No	No	0	4	5
148	R:R:K211	R:R:T209	4.5	No	No	7	1	5
149	R:R:T209	R:R:T222	4.71	No	No	7	5	4
150	R:R:K211	R:R:T220	3	No	No	0	1	4
151	R:R:K211	R:R:T222	3	No	No	7	1	4
152	R:R:I217	R:R:Y212	3.63	No	No	0	4	3
153	R:R:Q214	R:R:R213	9.35	No	No	0	2	2
154	R:R:R213	R:R:S216	3.95	No	Yes	3	2	1
155	R:R:D218	R:R:R213	7.15	No	No	3	4	2
156	R:R:D218	R:R:S216	5.89	No	Yes	3	4	1
157	R:R:F223	R:R:T227	9.08	No	No	0	6	3
158	R:R:S224	R:R:W230	3.71	No	No	0	3	1
159	R:R:P226	R:R:Y229	4.17	No	Yes	0	4	1
160	R:R:W228	R:R:Y229	5.79	No	Yes	0	1	1
161	R:R:W230	R:R:Y229	2.89	No	Yes	0	1	1
162	R:R:L233	R:R:Y229	3.52	No	Yes	0	3	1
163	R:R:E231	R:R:K235	5.4	No	Yes	0	4	4
164	R:R:K235	R:R:N232	4.2	Yes	No	0	4	2
165	R:R:K235	R:R:V302	3.04	Yes	No	0	4	5
166	R:R:I236	R:R:I240	2.94	No	No	0	4	5
167	R:R:C237	R:R:F241	4.19	No	No	0	5	4
168	R:R:F239	R:R:F243	4.29	No	No	0	6	8
169	R:R:F239	R:R:H299	4.53	No	Yes	0	6	7
170	R:R:F239	R:R:I303	16.33	No	No	0	6	5
171	R:R:F241	R:R:I240	3.77	No	No	0	4	5
172	R:R:A242	R:R:H299	2.93	No	Yes	0	5	7
173	R:R:F243	R:R:I244	3.77	No	No	0	8	4
174	R:R:F243	R:R:T296	6.49	No	Yes	0	8	5
175	R:R:M245	R:R:P246	3.35	No	Yes	0	5	8
176	R:R:I249	R:R:M245	2.92	No	No	0	6	5
177	R:R:F291	R:R:P246	2.89	No	Yes	0	9	8
178	R:R:I292	R:R:V247	4.61	No	No	0	6	6
179	R:R:M257	R:R:Y254	4.79	No	Yes	0	8	9
180	R:R:V284	R:R:Y254	3.79	No	Yes	0	8	9
181	R:R:I258	R:R:T281	6.08	No	No	0	5	6
182	R:R:I258	R:R:V284	7.68	No	No	0	5	8
183	R:R:L267	R:R:L277	8.3	Yes	No	0	1	6
184	R:R:G269	R:R:K273	3.49	No	No	0	1	3
185	R:R:K273	R:R:S270	7.65	No	No	0	3	2
186	R:R:E343	R:R:R279	9.3	No	No	8	5	7
187	R:R:K346	R:R:R279	3.71	No	No	8	8	7
188	R:R:L341	R:R:M283	7.07	No	No	0	7	8
189	R:R:I292	R:R:V288	3.07	No	No	0	6	8
190	R:R:N330	R:R:V290	2.96	Yes	Yes	1	9	7
191	R:R:L333	R:R:V290	2.98	No	Yes	1	6	7
192	R:R:L337	R:R:V290	4.47	No	Yes	1	8	7
193	R:R:F291	R:R:W295	9.02	No	Yes	1	9	8
194	R:R:F291	R:R:N330	4.83	No	Yes	1	9	9
195	R:R:I292	R:R:T296	3.04	No	Yes	0	6	5
196	R:R:C294	R:R:N330	9.45	No	Yes	0	9	9
197	R:R:H299	R:R:W295	3.17	Yes	Yes	0	7	8
198	R:R:N330	R:R:W295	10.17	Yes	Yes	1	9	8
199	R:R:P297	R:R:T296	3.5	No	Yes	0	9	5
200	R:R:C323	R:R:I298	4.91	No	No	0	6	6
201	R:R:I300	R:R:I304	2.94	No	No	0	6	5
202	R:R:K305	R:R:Y301	7.17	No	Yes	2	3	5
203	R:R:I310	R:R:Y301	4.84	No	Yes	2	4	5
204	R:R:Q316	R:R:Y301	5.64	Yes	Yes	2	3	5
205	R:R:W320	R:R:Y301	14.47	Yes	Yes	2	4	5
206	R:R:I303	R:R:L307	2.85	No	No	0	5	5
207	R:R:I310	R:R:K305	4.36	No	No	2	4	3
208	R:R:K305	R:R:W320	8.12	No	Yes	2	3	4
209	R:R:I310	R:R:P311	3.39	No	No	0	4	1
210	R:R:E312	R:R:Q316	8.92	No	Yes	0	2	3
211	R:R:Q316	R:R:T313	2.83	Yes	No	0	3	3
212	R:R:Q316	R:R:T317	5.67	Yes	No	0	3	4
213	R:R:Q316	R:R:W320	8.76	Yes	Yes	2	3	4
214	R:R:F322	R:R:L326	7.31	No	No	0	4	8
215	R:R:N330	R:R:N334	10.9	Yes	Yes	1	9	9
216	R:R:L333	R:R:V336	2.98	No	No	0	6	6
217	R:R:L333	R:R:L337	4.15	No	No	1	6	8
218	R:R:N334	R:R:Y338	5.81	Yes	Yes	1	9	9
219	R:R:D342	R:R:F345	3.58	No	Yes	0	8	8
220	R:R:E343	R:R:K346	5.4	No	No	8	5	8
221	R:R:N344	R:R:R347	4.82	No	No	0	7	5
222	R:R:A177	R:R:R181	2.77	No	No	0	6	7
223	R:R:L261	R:R:L267	2.77	No	Yes	0	8	1
224	R:R:F340	R:R:V91	2.62	No	Yes	0	6	9
225	R:R:F345	R:R:V94	2.62	Yes	No	0	8	7
226	R:R:F345	R:R:T99	2.59	Yes	No	0	8	6
227	R:R:V288	R:R:Y254	2.52	No	Yes	0	8	9
228	R:R:V287	R:R:Y338	2.52	No	Yes	0	8	9
229	R:R:F345	R:R:I109	2.51	Yes	No	0	8	8
230	R:R:F340	R:R:L90	2.44	No	No	0	6	6
231	R:R:I146	R:R:Y150	2.42	No	No	0	4	4
232	R:R:E272	R:R:R275	2.33	No	No	0	3	4
233	R:R:N232	R:R:W228	2.26	No	No	0	2	1
234	L:L:?5	R:R:T220	1.99	No	No	0	0	4
235	R:R:G215	R:R:S216	1.86	No	Yes	0	5	1
236	R:R:G84	R:R:T120	1.82	No	No	0	8	5
237	R:R:A104	R:R:A186	1.79	No	No	0	5	7
238	R:R:G133	R:R:M132	1.75	No	Yes	0	2	4
239	R:R:C323	R:R:S319	1.72	No	No	0	6	4
240	R:R:G87	R:R:L90	1.71	No	No	0	8	6
241	R:R:G327	R:R:L326	1.71	No	No	0	7	8
242	R:R:C192	R:R:I189	1.64	No	No	0	2	5
243	R:R:L326	R:R:P297	1.64	No	No	0	8	9
244	R:R:S127	R:R:V128	1.62	No	No	0	6	3
245	R:R:A177	R:R:I169	1.62	No	No	0	6	5
246	R:R:A306	R:R:K235	1.61	No	Yes	0	4	4
247	R:R:S121	R:R:T122	1.6	No	No	0	5	6
248	R:R:S216	R:R:T134	1.6	Yes	Yes	3	1	5
249	R:R:V286	R:R:V290	1.6	No	Yes	0	6	7
250	R:R:T251	R:R:V247	1.59	No	No	0	5	6
251	R:R:T251	R:R:V288	1.59	No	No	0	5	8
252	R:R:A70	R:R:L131	1.58	No	No	0	4	4
253	R:R:A208	R:R:L221	1.58	No	No	0	5	4
254	R:R:A119	R:R:N152	1.56	No	Yes	0	7	8
255	R:R:I79	R:R:V83	1.54	No	No	0	4	5
256	R:R:I169	R:R:V165	1.54	No	No	0	5	6
257	R:R:I249	R:R:V165	1.54	No	No	0	6	6
258	R:R:I195	R:R:V191	1.54	No	No	0	4	4
259	R:R:I304	R:R:V308	1.54	No	No	0	5	2
260	R:R:I68	R:R:T69	1.52	No	No	0	3	4
261	R:R:I68	R:R:T72	1.52	No	No	0	3	4
262	R:R:M132	R:R:V128	1.52	Yes	No	0	4	3
263	R:R:I217	R:R:T210	1.52	No	No	0	4	4
264	R:R:M266	R:R:V264	1.52	No	No	0	4	6
265	R:R:I300	R:R:T296	1.52	No	Yes	0	6	5
266	R:R:L202	R:R:S198	1.5	No	No	0	4	4
267	R:R:L76	R:R:V80	1.49	No	No	0	5	7
268	R:R:L123	R:R:V80	1.49	No	No	0	7	7
269	R:R:L234	R:R:V238	1.49	No	No	0	6	5
270	R:R:L248	R:R:V252	1.49	No	No	0	3	4
271	R:R:L256	R:R:V252	1.49	No	No	0	5	4
272	R:R:L261	R:R:V264	1.49	No	No	0	8	6
273	R:R:I140	R:R:I144	1.47	No	No	0	1	5
274	R:R:I240	R:R:I244	1.47	No	No	0	5	4
275	R:R:I258	R:R:I280	1.47	No	No	0	5	8
276	R:R:L285	R:R:T281	1.47	No	No	0	5	6
277	R:R:I144	R:R:M205	1.46	No	No	0	5	5
278	R:R:I107	R:R:K187	1.45	No	No	0	5	2
279	R:R:G201	R:R:Y151	1.45	No	Yes	0	6	5
280	R:R:E272	R:R:S270	1.44	No	No	0	3	2
281	R:R:K273	R:R:L267	1.41	No	Yes	0	3	1
282	R:R:D179	R:R:K176	1.38	No	No	0	5	4
283	R:R:L337	R:R:L341	1.38	No	No	0	8	7
284	R:R:L267	R:R:N276	1.37	Yes	No	0	1	5
285	R:R:R97	R:R:V96	1.31	No	No	0	5	3
286	R:R:R282	R:R:V286	1.31	No	No	0	5	6
287	R:R:F315	R:R:T313	1.3	No	No	0	2	3
288	R:R:S198	R:R:Y151	1.27	No	Yes	0	4	5
289	R:R:F180	R:R:I169	1.26	No	No	0	3	5
290	R:R:M283	R:R:R279	1.24	No	No	0	8	7
291	R:R:F89	R:R:L85	1.22	No	No	0	4	6
292	R:R:F223	R:R:H225	1.13	No	No	0	6	2
293	R:R:R97	R:R:Y98	1.03	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y1	7.63333	6	2	0
2	L:L:?2	7.31	5	2	0
3	L:L:?4	10.89	5	2	0
4	R:R:N88	4.5425	4	1	9
5	R:R:V91	3.1175	4	0	9
6	R:R:I95	3.175	4	5	7
7	R:R:Y108	5.122	5	6	7
8	R:R:N111	10.835	4	1	9
9	R:R:L112	4.77167	6	1	9
10	R:R:D116	6.03	5	1	9
11	R:R:Q126	6.53	4	2	6
12	R:R:Y130	5.9925	4	4	5
13	R:R:M132	2.4075	4	3	4
14	R:R:T134	3.9275	4	3	5
15	R:R:W135	8.002	5	2	8
16	R:R:V145	4.575	4	2	5
17	R:R:Y151	4.57167	6	1	5
18	R:R:N152	6.0575	4	0	8
19	R:R:T155	6.1075	4	1	7
20	R:R:Y168	7.485	4	0	8
21	R:R:W194	8.9	5	1	9
22	R:R:S216	3.325	4	3	1
23	R:R:Y229	4.0925	4	0	1
24	R:R:K235	3.5625	4	0	4
25	R:R:P246	3.35	4	0	8
26	R:R:Y254	5.3175	4	0	9
27	R:R:L267	3.4625	4	0	1
28	R:R:V290	3.0025	4	1	7
29	R:R:W295	7.335	4	1	8
30	R:R:T296	3.6375	4	0	5
31	R:R:H299	6.1975	4	0	7
32	R:R:Y301	8.03	4	2	5
33	R:R:Q316	6.364	5	2	3
34	R:R:W320	9.285	4	2	4
35	R:R:N330	7.662	5	1	9
36	R:R:N334	6.925	4	1	9
37	R:R:Y338	4.07	6	1	9
38	R:R:F345	2.825	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:Y1	100	10.73	Yes	Yes	2	0	0
2	L:L:Y1	R:R:M153	33.5597	7.18	Yes	No	0	0	7
3	L:L:Y1	R:R:V238	32.6717	3.79	Yes	No	0	0	5
4	L:L:Y1	R:R:H299	83.5597	14.16	Yes	Yes	0	0	7
5	L:L:Y1	R:R:V302	23.1588	6.31	Yes	No	0	0	5
6	L:L:?2	R:R:I324	28.7804	7.26	Yes	No	0	0	5
7	R:R:I324	R:R:Q126	21.7159	6.86	No	Yes	0	5	6
8	R:R:I324	R:R:Y77	16.9496	9.67	No	No	0	5	7
9	R:R:H321	R:R:Y77	15.3238	13.07	No	No	0	4	7
10	R:R:H321	R:R:Y130	12.105	13.07	No	Yes	4	4	5
11	L:L:?2	R:R:W320	31.6205	5.79	Yes	Yes	2	0	4
12	R:R:Q316	R:R:W320	18.5362	8.76	Yes	Yes	2	3	4
13	R:R:Q316	R:R:T317	11.5631	5.67	Yes	No	0	3	4
14	R:R:L131	R:R:Y130	18.9475	3.52	No	Yes	0	4	5
15	R:R:L131	R:R:M74	13.672	4.24	No	No	0	4	5
16	R:R:M74	R:R:S127	11.0864	6.13	No	No	0	5	6
17	L:L:?2	L:L:G3	56.7511	6.96	Yes	No	2	0	0
18	L:L:G3	R:R:Q126	16.3685	3.29	No	Yes	2	0	6
19	R:R:Q126	R:R:Y328	51.2862	6.76	Yes	No	0	6	7
20	R:R:L123	R:R:Y328	22.643	16.41	No	No	0	7	7
21	R:R:C81	R:R:L123	14.5795	4.76	No	No	0	6	7
22	R:R:C81	R:R:L85	11.5761	3.17	No	No	0	6	6
23	R:R:L85	R:R:T120	10.3617	4.42	No	No	0	6	5
24	R:R:F154	R:R:V238	30.4257	6.55	No	No	0	6	5
25	R:R:F154	R:R:F158	28.8065	3.22	No	No	0	6	5
26	R:R:F158	R:R:N193	27.8663	4.83	No	No	0	5	7
27	R:R:N111	R:R:N193	25.2024	5.45	Yes	No	1	9	7
28	R:R:N111	R:R:W194	54.1721	11.3	Yes	Yes	1	9	9
29	R:R:L114	R:R:W194	37.6534	5.69	No	Yes	0	7	9
30	R:R:L114	R:R:M92	46.0499	2.83	No	No	0	7	7
31	R:R:F110	R:R:M92	44.3588	6.22	No	No	0	6	7
32	R:R:F110	R:R:I95	37.0723	3.77	No	Yes	5	6	7
33	R:R:I95	R:R:V91	13.7503	3.07	Yes	Yes	0	7	9
34	R:R:M153	R:R:W295	23.6681	6.98	No	Yes	0	7	8
35	R:R:N330	R:R:W295	71.9444	10.17	Yes	Yes	1	9	8
36	R:R:N330	R:R:N334	59.872	10.9	Yes	Yes	1	9	9
37	R:R:L112	R:R:N334	35.6882	4.12	Yes	Yes	1	9	9
38	R:R:D116	R:R:L112	16.4011	9.5	Yes	Yes	1	9	9
39	R:R:H299	R:R:W295	56.3855	3.17	Yes	Yes	0	7	8
40	R:R:D116	R:R:N88	13.1039	4.04	Yes	Yes	1	9	9
41	R:R:N88	R:R:T120	12.0593	2.92	Yes	No	0	9	5
42	R:R:I109	R:R:I95	23.0478	2.94	No	Yes	0	8	7
43	R:R:F345	R:R:I109	19.3131	2.51	Yes	No	0	8	8
44	R:R:N334	R:R:Y338	21.3633	5.81	Yes	Yes	1	9	9
45	R:R:M163	R:R:Y338	24.3014	4.79	No	Yes	0	9	9
46	R:R:M163	R:R:Y108	22.421	5.99	No	Yes	0	9	7
47	R:R:D149	R:R:Y328	32.5738	5.75	No	No	0	5	7
48	R:R:D149	R:R:T122	30.726	5.78	No	No	0	5	6
49	R:R:I148	R:R:T122	27.5921	3.04	No	No	0	5	6
50	R:R:I148	R:R:N152	22.3688	5.66	No	Yes	0	5	8
51	R:R:L118	R:R:N152	11.8699	12.36	No	Yes	0	7	8
52	L:L:?4	L:L:G3	39.9321	10.36	Yes	No	2	0	0
53	L:L:?4	R:R:V145	47.8911	3.87	Yes	Yes	2	0	5
54	R:R:V145	R:R:W135	40.252	4.9	Yes	Yes	2	5	8
55	R:R:C142	R:R:W135	24.3667	3.92	No	Yes	2	9	8
56	R:R:C142	R:R:T210	23.2633	3.38	No	No	0	9	4
57	R:R:I217	R:R:T210	18.8822	1.52	No	No	0	4	4
58	R:R:I217	R:R:T134	15.7221	7.6	No	Yes	0	4	5
59	R:R:C219	R:R:W135	13.3782	9.14	No	Yes	2	9	8
60	R:R:C219	R:R:I146	12.0985	3.27	No	No	0	9	4
61	R:R:W194	R:R:Y151	14.8276	8.68	Yes	Yes	1	9	5
62	R:R:N152	R:R:Y151	10.3748	4.65	Yes	Yes	0	8	5
63	R:R:I157	R:R:M153	11.1844	2.92	No	No	0	7	7
64	R:R:F239	R:R:H299	93.2424	4.53	No	Yes	0	6	7
65	R:R:F239	R:R:F243	88.7699	4.29	No	No	0	6	8
66	R:R:F243	R:R:T296	79.5247	6.49	No	Yes	0	8	5
67	R:R:I292	R:R:T296	66.4664	3.04	No	Yes	0	6	5
68	R:R:I292	R:R:V288	61.1387	3.07	No	No	0	6	8
69	R:R:V288	R:R:Y254	57.8676	2.52	No	Yes	0	8	9
70	R:R:S164	R:R:Y254	22.6365	10.17	No	Yes	0	9	9
71	R:R:C253	R:R:S164	18.6145	3.44	No	No	0	8	9
72	R:R:M245	R:R:P246	12.4249	3.35	No	Yes	0	5	8
73	R:R:I249	R:R:M245	10.7469	2.92	No	No	0	6	5
74	R:R:C253	R:R:Y168	16.584	9.41	No	Yes	0	8	8
75	R:R:M257	R:R:Y254	26.5866	4.79	No	Yes	0	8	9
76	R:R:M257	R:R:V171	24.6017	7.61	No	No	0	8	8
77	R:R:L261	R:R:V171	22.754	2.98	No	No	0	8	8
78	R:R:K235	R:R:V302	21.2066	3.04	Yes	No	0	4	5
79	R:R:K235	R:R:N232	15.0757	4.2	Yes	No	0	4	2
80	R:R:N232	R:R:W228	12.9603	2.26	No	No	0	2	1
81	R:R:W228	R:R:Y229	10.8318	5.79	No	Yes	0	1	1
82	R:R:F243	R:R:I244	10.538	3.77	No	No	0	8	4
83	R:R:V284	R:R:Y254	10.3878	3.79	No	Yes	0	8	9
84	R:R:L261	R:R:L267	16.708	2.77	No	Yes	0	8	1
85	R:R:K273	R:R:L267	10.538	1.41	No	Yes	0	3	1
86	R:R:N330	R:R:V290	26.6845	2.96	Yes	Yes	1	9	7
87	R:R:L337	R:R:V290	14.5599	4.47	No	Yes	1	8	7
88	R:R:L337	R:R:L341	12.1899	1.38	No	No	0	8	7
89	R:R:L114	R:R:L118	12.5881	4.15	No	No	0	7	7
90	R:R:N111	R:R:T159	32.0906	10.24	Yes	No	1	9	8
91	R:R:L112	R:R:T159	34.3105	2.95	Yes	No	1	9	8
92	L:L:?4	R:R:Q126	17.5242	9.21	Yes	Yes	2	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y1	R:R:M153	7.18	2	Yes	No	0	7	0	1
L:L:Y1	R:R:V238	3.79	2	Yes	No	0	5	0	1
L:L:Y1	R:R:I298	3.63	2	Yes	No	0	6	0	1
L:L:Y1	R:R:H299	14.16	2	Yes	Yes	0	7	0	1
L:L:Y1	R:R:V302	6.31	2	Yes	No	0	5	0	1
L:L:?2	R:R:I298	5.81	2	Yes	No	0	6	0	1
L:L:?2	R:R:W320	5.79	2	Yes	Yes	0	4	0	1
L:L:?2	R:R:I324	7.26	2	Yes	No	0	5	0	1
L:L:G3	R:R:Q126	3.29	2	No	Yes	0	6	0	1
L:L:?4	R:R:Q126	9.21	2	Yes	Yes	0	6	0	1
L:L:?4	R:R:N129	3.56	2	Yes	No	0	4	0	1
L:L:?4	R:R:V145	3.87	2	Yes	Yes	0	5	0	1
R:R:I324	R:R:Y77	9.67	0	No	No	5	7	1	2
R:R:F125	R:R:W135	4.01	2	No	Yes	6	8	2	2
R:R:F125	R:R:V145	6.55	2	No	Yes	6	5	2	1
R:R:I324	R:R:Q126	6.86	0	No	Yes	5	6	1	1
R:R:Q126	R:R:Y328	6.76	2	Yes	No	6	7	1	2
R:R:V145	R:R:W135	4.9	2	Yes	Yes	5	8	1	2
R:R:L141	R:R:V145	2.98	0	No	Yes	5	5	2	1
R:R:I157	R:R:M153	2.92	0	No	No	7	7	2	1
R:R:M153	R:R:W295	6.98	0	No	Yes	7	8	1	2
R:R:F154	R:R:V238	6.55	0	No	No	6	5	2	1
R:R:K211	R:R:T220	3	7	No	No	1	4	2	1
R:R:K235	R:R:V302	3.04	0	Yes	No	4	5	2	1
R:R:F239	R:R:H299	4.53	0	No	Yes	6	7	2	1
R:R:A242	R:R:H299	2.93	0	No	Yes	5	7	2	1
R:R:H299	R:R:W295	3.17	0	Yes	Yes	7	8	1	2
R:R:C323	R:R:I298	4.91	0	No	No	6	6	2	1
R:R:K305	R:R:Y301	7.17	2	No	Yes	3	5	2	2
R:R:Q316	R:R:Y301	5.64	2	Yes	Yes	3	5	2	2
R:R:W320	R:R:Y301	14.47	2	Yes	Yes	4	5	1	2
R:R:K305	R:R:W320	8.12	2	No	Yes	3	4	2	1
R:R:Q316	R:R:W320	8.76	2	Yes	Yes	3	4	2	1
L:L:?5	R:R:T220	1.99	0	No	No	0	4	0	1
R:R:L234	R:R:V238	1.49	0	No	No	6	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8EFQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	260
Number of Links	293
Number of Hubs	38
Number of Links mediated by Hubs	142
Number of Communities	8
Number of Nodes involved in Communities	60
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	41100
Length Of Smallest Path	3
Average Path Length	13.4
Length of Longest Path	32
Minimum Path Strength	1.17
Average Path Strength	5.8436
Maximum Path Strength	17.14
Minimum Path Correlation	0.7
Average Path Correlation	0.91747
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.5826
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1326
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • protein binding • binding • G-protein beta-subunit binding • neuropeptide binding • peptide binding • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • metabolic process • regulation of nitric oxide metabolic process • regulation of metabolic process • multicellular organismal process • system process • sensory perception • nervous system process • behavior • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • synapse • cell junction • axon • endoplasmic reticulum • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	MEA
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951134
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ETA
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	ETA
Name	Ethanolamine
Synonyms	Ethanolamine hydrochloride Ethanolamine acetate Ethanolamine
Identifier
Formula	C2 H7 N O
Molecular Weight	61.083
SMILES
PubChem	700
Formal Charge	0
Total Atoms	11
Total Chiral Atoms	0
Total Bonds	10
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>8EFQ_nogp_Chain_R M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

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