CodeDAL
NameD-Alanine
SynonymsD-Alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0
Networks53
 missing image

This ligand is also present in the following 53 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6DDE A Peptide Opioid MOP Mus Musculus DAMGO - Gi1/Beta1/Gamma2 3.5 2018-06-13 doi.org/10.1038/s41586-018-0219-7

A 2D representation of the interactions of DAL in 6DDE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 10.71 1 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y148 6.95 0 Yes No 0 4 1 2
L:L:Y1 R:R:M151 11.97 0 Yes No 0 7 1 2
L:L:Y1 R:R:V236 5.05 0 Yes No 0 5 1 2
L:L:Y1 R:R:H297 6.53 0 Yes Yes 0 8 1 2
L:L:Y1 R:R:V300 10.09 0 Yes No 0 5 1 2
L:L:?2 L:L:G3 6.94 1 Yes No 0 0 0 1
L:L:?2 R:R:I296 2.9 1 Yes Yes 0 6 0 1
L:L:?2 R:R:W318 9.25 1 Yes Yes 0 5 0 1
L:L:?2 R:R:I322 8.69 1 Yes Yes 0 5 0 1
L:L:?4 L:L:G3 8.82 1 Yes No 0 0 2 1
L:L:?4 L:L:?5 20.99 1 Yes No 0 0 2 2
L:L:?5 R:R:K303 5.74 1 No No 0 4 2 2
L:L:?5 R:R:W318 6.18 1 No Yes 0 5 2 1
R:R:H319 R:R:Y75 3.27 1 Yes Yes 4 7 2 2
R:R:I322 R:R:Y75 4.84 1 Yes Yes 5 7 1 2
R:R:I296 R:R:W293 3.52 1 Yes Yes 6 8 1 2
R:R:G325 R:R:W293 2.81 1 No Yes 7 8 2 2
R:R:H297 R:R:I296 3.98 1 Yes Yes 8 6 2 1
R:R:C321 R:R:I296 3.27 0 No Yes 6 6 2 1
R:R:I296 R:R:I322 2.94 1 Yes Yes 6 5 1 1
R:R:G325 R:R:I296 3.53 1 No Yes 7 6 2 1
R:R:W318 R:R:Y299 12.54 1 Yes No 5 4 1 2
R:R:K303 R:R:W318 3.48 1 No Yes 4 5 2 1
R:R:H319 R:R:I322 3.98 1 Yes Yes 4 5 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.70
Average Nodes In Shell20.00
Average Hubs In Shell10.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6DDF A Peptide Opioid MOP Mus Musculus DAMGO - Gi1/Beta1/Gamma2 3.5 2018-06-13 doi.org/10.1038/s41586-018-0219-7

A 2D representation of the interactions of DAL in 6DDF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q124 R:R:Y75 4.51 1 Yes Yes 6 7 2 2
R:R:I322 R:R:Y75 7.25 1 Yes Yes 5 7 1 2
R:R:D147 R:R:Q124 2.61 1 Yes Yes 6 6 2 2
L:L:?4 R:R:Q124 6.86 1 Yes Yes 0 6 1 2
R:R:V143 R:R:W133 7.36 1 No Yes 5 8 2 2
R:R:C217 R:R:W133 20.89 1 Yes Yes 9 8 2 2
L:L:?4 R:R:W133 4.89 1 Yes Yes 0 8 1 2
L:L:?4 R:R:V143 3.84 1 Yes No 0 5 1 2
R:R:I144 R:R:Y148 2.42 1 Yes Yes 5 4 2 2
R:R:C217 R:R:I144 3.27 1 Yes Yes 9 5 2 2
L:L:?4 R:R:I144 11.04 1 Yes Yes 0 5 1 2
R:R:D147 R:R:Y148 3.45 1 Yes Yes 6 4 2 2
R:R:D147 R:R:Y326 5.75 1 Yes No 6 7 2 2
L:L:?4 R:R:D147 3.5 1 Yes Yes 0 6 1 2
L:L:Y1 R:R:Y148 6.95 1 Yes Yes 0 4 1 2
R:R:H297 R:R:M151 2.63 1 Yes No 8 7 2 2
L:L:Y1 R:R:M151 8.38 1 Yes No 0 7 1 2
L:L:?4 R:R:C217 4.09 1 Yes Yes 0 9 1 2
L:L:Y1 R:R:V236 7.57 1 Yes No 0 5 1 2
R:R:I296 R:R:W293 3.52 1 Yes Yes 6 8 1 2
R:R:H297 R:R:W293 6.35 1 Yes Yes 8 8 2 2
R:R:G325 R:R:W293 2.81 1 No Yes 7 8 2 2
R:R:H297 R:R:I296 3.98 1 Yes Yes 8 6 2 1
R:R:C321 R:R:I296 4.91 0 No Yes 6 6 2 1
R:R:I296 R:R:I322 2.94 1 Yes Yes 6 5 1 1
R:R:G325 R:R:I296 3.53 1 No Yes 7 6 2 1
L:L:Y1 R:R:I296 3.63 1 Yes Yes 0 6 1 1
L:L:?2 R:R:I296 2.9 1 Yes Yes 0 6 0 1
L:L:Y1 R:R:H297 2.18 1 Yes Yes 0 8 1 2
R:R:K303 R:R:Y299 11.94 1 No No 4 4 2 2
R:R:W318 R:R:Y299 13.5 1 Yes No 5 4 1 2
L:L:Y1 R:R:V300 10.09 1 Yes No 0 5 1 2
R:R:K303 R:R:W318 3.48 1 No Yes 4 5 2 1
L:L:?5 R:R:K303 5.74 1 Yes No 0 4 1 2
R:R:C321 R:R:W318 2.61 0 No Yes 6 5 2 1
L:L:?2 R:R:W318 10.4 1 Yes Yes 0 5 0 1
L:L:?5 R:R:W318 7.73 1 Yes Yes 0 5 1 1
R:R:I322 R:R:Y326 2.42 1 Yes No 5 7 1 2
L:L:?2 R:R:I322 5.79 1 Yes Yes 0 5 0 1
L:L:G3 R:R:I322 1.76 1 No Yes 0 5 1 1
L:L:?2 L:L:Y1 11.89 1 Yes Yes 0 0 0 1
L:L:?2 L:L:G3 6.94 1 Yes No 0 0 0 1
L:L:?2 L:L:?4 4.83 1 Yes Yes 0 0 0 1
L:L:?2 L:L:?5 7.63 1 Yes Yes 0 0 0 1
L:L:?4 L:L:G3 5.88 1 Yes No 0 0 1 1
L:L:?4 L:L:?5 20.99 1 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.20
Average Nodes In Shell26.00
Average Hubs In Shell16.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7AUE A Peptide Melanocortin MC4 Homo Sapiens Setmelanotide - chim(NtGi1L-Gs)/Beta1/Gamma2 2.97 2021-04-28 doi.org/10.1126/science.abf7958

A 2D representation of the interactions of DAL in 7AUE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?4 L:L:H5 6.52 0 No No 0 0 0 1
L:L:?4 R:R:I104 5.79 0 No No 0 4 0 1
L:L:H5 R:R:F51 18.1 29 No Yes 0 6 1 2
L:L:H5 R:R:T101 6.85 29 No Yes 0 6 1 2
R:R:F51 R:R:T101 7.78 29 Yes Yes 6 6 2 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength6.15
Average Nodes In Shell5.00
Average Hubs In Shell2.00
Average Links In Shell5.00
Average Links Mediated by Hubs In Shell3.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F9Z A Peptide Ghrelin Ghrelin Homo Sapiens GHRP-6 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.2 2021-08-18 doi.org/10.1038/s41467-021-25364-2

A 2D representation of the interactions of DAL in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:?2 16.07 0 No Yes 0 0 2 1
L:L:?2 L:L:?3 30.01 3 Yes Yes 0 0 1 0
L:L:?2 L:L:?6 9.47 3 Yes Yes 0 0 1 2
L:L:?2 R:R:D99 5.37 3 Yes No 0 6 1 2
L:L:?2 R:R:L103 8.76 3 Yes No 0 4 1 2
L:L:?2 R:R:Q302 11.59 3 Yes No 0 3 1 2
L:L:?2 R:R:F309 9.64 3 Yes Yes 0 5 1 2
L:L:?3 L:L:?4 17.78 3 Yes Yes 0 0 0 1
L:L:?3 R:R:F286 9.89 3 Yes Yes 0 4 0 1
L:L:?3 R:R:N305 22.29 3 Yes No 0 4 0 1
L:L:?4 L:L:?5 13.89 3 Yes Yes 0 0 1 2
L:L:?4 L:L:?6 9.47 3 Yes Yes 0 0 1 2
L:L:?4 R:R:F286 3.86 3 Yes Yes 0 4 1 1
L:L:?4 R:R:S308 4.75 3 Yes No 0 7 1 2
L:L:?4 R:R:F309 8.67 3 Yes Yes 0 5 1 2
L:L:?5 L:L:?6 28.35 3 Yes Yes 0 0 2 2
L:L:?6 R:R:D99 4.69 3 Yes No 0 6 2 2
R:R:D99 R:R:F309 9.55 3 No Yes 6 5 2 2
R:R:F286 R:R:S289 3.96 3 Yes No 4 2 1 2
R:R:F286 R:R:F290 8.57 3 Yes No 4 1 1 2
R:R:N305 R:R:S301 4.47 0 No No 4 4 1 2
R:R:G282 R:R:N305 3.39 0 No No 4 4 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength19.99
Average Nodes In Shell17.00
Average Hubs In Shell7.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7M3G C Ion Calcium Sensing CaS; CaS Homo Sapiens - Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 - 2.5 2021-06-30 doi.org/10.1038/s41586-021-03691-0

A 2D representation of the interactions of DAL in 7M3G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E191 R:R:R172 9.3 2 Yes Yes 3 4 2 2
R:R:R172 S:S:D215 9.53 2 Yes Yes 4 6 2 2
R:R:R172 W:W:?5 4.84 2 Yes Yes 4 0 2 1
R:R:R172 W:W:?8 5.81 2 Yes Yes 4 0 2 2
R:R:D484 R:R:S175 5.89 2 Yes No 8 8 2 2
R:R:S175 W:W:?6 5.99 2 No Yes 8 0 2 1
R:R:N189 W:W:?6 5.47 0 No Yes 8 0 2 1
R:R:E191 R:R:K225 13.5 2 Yes Yes 3 3 2 2
R:R:E191 W:W:?6 6.34 2 Yes Yes 3 0 2 1
R:R:E191 W:W:?7 13.45 2 Yes Yes 3 0 2 1
R:R:E191 W:W:?8 10.57 2 Yes Yes 3 0 2 2
R:R:E191 W:W:?9 3.3 2 Yes Yes 3 0 2 2
R:R:K225 W:W:?7 10.02 2 Yes Yes 3 0 2 1
R:R:K225 W:W:?9 10.53 2 Yes Yes 3 0 2 2
R:R:C482 R:R:D480 3.11 2 Yes No 7 7 1 2
R:R:D480 R:R:D484 7.98 2 No Yes 7 8 2 2
R:R:D480 W:W:?6 4.33 2 No Yes 7 0 2 1
R:R:C482 R:R:E481 3.04 2 Yes No 7 4 1 2
R:R:C482 W:W:?2 11.86 2 Yes Yes 7 0 1 1
R:R:C482 W:W:?3 3.22 2 Yes Yes 7 0 1 0
R:R:D484 W:W:?6 6.49 2 Yes Yes 8 0 2 1
S:S:D215 W:W:?5 5.41 2 Yes Yes 6 0 2 1
S:S:S244 W:W:?5 4.79 0 No Yes 4 0 2 1
S:S:E251 S:S:S247 4.31 2 Yes No 4 2 2 2
S:S:S247 W:W:?5 4.79 2 No Yes 2 0 2 1
S:S:D248 S:S:E251 14.29 2 No Yes 3 4 2 2
S:S:D248 W:W:?1 6.11 2 No Yes 3 0 2 1
S:S:E251 W:W:?1 5.97 2 Yes Yes 4 0 2 1
S:S:E251 W:W:?4 7.4 2 Yes Yes 4 0 2 1
S:S:E251 W:W:?5 10.57 2 Yes Yes 4 0 2 1
S:S:H254 W:W:?4 8.2 0 No Yes 3 0 2 1
W:W:?1 W:W:?2 23.28 2 Yes Yes 0 0 1 1
W:W:?1 W:W:?3 6.32 2 Yes Yes 0 0 1 0
W:W:?2 W:W:?3 20.99 2 Yes Yes 0 0 1 0
W:W:?2 W:W:?6 8.25 2 Yes Yes 0 0 1 1
W:W:?3 W:W:?4 19.04 2 Yes Yes 0 0 0 1
W:W:?3 W:W:?5 3.36 2 Yes Yes 0 0 0 1
W:W:?3 W:W:?6 14.56 2 Yes Yes 0 0 0 1
W:W:?3 W:W:?7 2.85 2 Yes Yes 0 0 0 1
W:W:?4 W:W:?5 14.08 2 Yes Yes 0 0 1 1
W:W:?4 W:W:?6 6.16 2 Yes Yes 0 0 1 1
W:W:?4 W:W:?7 7.84 2 Yes Yes 0 0 1 1
W:W:?5 W:W:?6 14.96 2 Yes Yes 0 0 1 1
W:W:?5 W:W:?7 7.84 2 Yes Yes 0 0 1 1
W:W:?5 W:W:?8 6.16 2 Yes Yes 0 0 1 2
W:W:?6 W:W:?7 15.68 2 Yes Yes 0 0 1 1
W:W:?7 W:W:?8 23.52 2 Yes Yes 0 0 1 2
W:W:?7 W:W:?9 6.99 2 Yes Yes 0 0 1 2
W:W:?8 W:W:?9 13.73 2 Yes Yes 0 0 2 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.05
Average Nodes In Shell24.00
Average Hubs In Shell16.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAL in 7M3G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E191 R:R:R172 9.3 2 Yes Yes 3 4 1 2
R:R:R172 S:S:D215 9.53 2 Yes Yes 4 6 2 2
R:R:R172 W:W:?5 4.84 2 Yes Yes 4 0 2 1
R:R:R172 W:W:?8 5.81 2 Yes Yes 4 0 2 1
R:R:D484 R:R:S175 5.89 2 Yes No 8 8 2 2
R:R:S175 W:W:?6 5.99 2 No Yes 8 0 2 1
R:R:N189 W:W:?6 5.47 0 No Yes 8 0 2 1
R:R:E191 R:R:K225 13.5 2 Yes Yes 3 3 1 1
R:R:E191 W:W:?6 6.34 2 Yes Yes 3 0 1 1
R:R:E191 W:W:?7 13.45 2 Yes Yes 3 0 1 0
R:R:E191 W:W:?8 10.57 2 Yes Yes 3 0 1 1
R:R:E191 W:W:?9 3.3 2 Yes Yes 3 0 1 1
R:R:A194 R:R:K225 3.21 0 No Yes 7 3 2 1
R:R:E229 R:R:K225 9.45 0 No Yes 5 3 2 1
R:R:K225 W:W:?7 10.02 2 Yes Yes 3 0 1 0
R:R:K225 W:W:?9 10.53 2 Yes Yes 3 0 1 1
R:R:E228 W:W:?8 21.13 2 No Yes 3 0 2 1
R:R:E228 W:W:?9 6.59 2 No Yes 3 0 2 1
R:R:C482 R:R:D480 3.11 2 Yes No 7 7 2 2
R:R:D480 R:R:D484 7.98 2 No Yes 7 8 2 2
R:R:D480 W:W:?6 4.33 2 No Yes 7 0 2 1
R:R:C482 W:W:?2 11.86 2 Yes Yes 7 0 2 2
R:R:C482 W:W:?3 3.22 2 Yes Yes 7 0 2 1
R:R:D484 W:W:?6 6.49 2 Yes Yes 8 0 2 1
S:S:D215 W:W:?5 5.41 2 Yes Yes 6 0 2 1
S:S:E241 W:W:?8 8.45 0 No Yes 5 0 2 1
S:S:S244 W:W:?5 4.79 0 No Yes 4 0 2 1
S:S:E251 S:S:S247 4.31 2 Yes No 4 2 2 2
S:S:S247 W:W:?5 4.79 2 No Yes 2 0 2 1
S:S:E251 W:W:?1 5.97 2 Yes Yes 4 0 2 2
S:S:E251 W:W:?4 7.4 2 Yes Yes 4 0 2 1
S:S:E251 W:W:?5 10.57 2 Yes Yes 4 0 2 1
S:S:H254 W:W:?4 8.2 0 No Yes 3 0 2 1
W:W:?1 W:W:?2 23.28 2 Yes Yes 0 0 2 2
W:W:?1 W:W:?3 6.32 2 Yes Yes 0 0 2 1
W:W:?2 W:W:?3 20.99 2 Yes Yes 0 0 2 1
W:W:?2 W:W:?6 8.25 2 Yes Yes 0 0 2 1
W:W:?3 W:W:?4 19.04 2 Yes Yes 0 0 1 1
W:W:?3 W:W:?5 3.36 2 Yes Yes 0 0 1 1
W:W:?3 W:W:?6 14.56 2 Yes Yes 0 0 1 1
W:W:?3 W:W:?7 2.85 2 Yes Yes 0 0 1 0
W:W:?4 W:W:?5 14.08 2 Yes Yes 0 0 1 1
W:W:?4 W:W:?6 6.16 2 Yes Yes 0 0 1 1
W:W:?4 W:W:?7 7.84 2 Yes Yes 0 0 1 0
W:W:?5 W:W:?6 14.96 2 Yes Yes 0 0 1 1
W:W:?5 W:W:?7 7.84 2 Yes Yes 0 0 1 0
W:W:?5 W:W:?8 6.16 2 Yes Yes 0 0 1 1
W:W:?6 W:W:?7 15.68 2 Yes Yes 0 0 1 0
W:W:?7 W:W:?8 23.52 2 Yes Yes 0 0 0 1
W:W:?7 W:W:?9 6.99 2 Yes Yes 0 0 0 1
W:W:?8 W:W:?9 13.73 2 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub8.00
Average Interaction Strength11.02
Average Nodes In Shell26.00
Average Hubs In Shell16.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell51.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAL in 7M3G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D248 R:R:E251 16.89 1 No Yes 3 4 2 2
R:R:D248 X:X:?1 6.11 1 No Yes 3 0 2 1
R:R:E251 X:X:?1 5.97 1 Yes Yes 4 0 2 1
R:R:E251 X:X:?4 6.34 1 Yes Yes 4 0 2 1
R:R:E251 X:X:?5 12.68 1 Yes Yes 4 0 2 2
R:R:H254 X:X:?4 7.18 1 No Yes 3 0 2 1
S:S:E191 S:S:R172 8.14 1 Yes Yes 3 4 2 2
S:S:R172 X:X:?5 4.84 1 Yes Yes 4 0 2 2
S:S:R172 X:X:?6 4.84 1 Yes Yes 4 0 2 1
S:S:R172 X:X:?8 7.75 1 Yes Yes 4 0 2 2
S:S:R172 X:X:?9 3.02 1 Yes Yes 4 0 2 2
S:S:D484 S:S:S175 5.89 1 Yes No 8 8 2 2
S:S:S175 X:X:?6 5.99 1 No Yes 8 0 2 1
S:S:D484 S:S:N189 5.39 1 Yes No 8 8 2 2
S:S:N189 X:X:?6 9.85 1 No Yes 8 0 2 1
S:S:E191 S:S:K225 17.55 1 Yes Yes 3 3 2 2
S:S:E191 X:X:?6 8.45 1 Yes Yes 3 0 2 1
S:S:E191 X:X:?7 9.41 1 Yes Yes 3 0 2 1
S:S:E191 X:X:?8 3.17 1 Yes Yes 3 0 2 2
S:S:E191 X:X:?9 6.59 1 Yes Yes 3 0 2 2
S:S:K225 X:X:?7 11.45 1 Yes Yes 3 0 2 1
S:S:K225 X:X:?9 10.53 1 Yes Yes 3 0 2 2
S:S:D480 S:S:E481 6.5 1 No No 7 4 2 2
S:S:D480 S:S:D484 9.31 1 No Yes 7 8 2 2
S:S:D480 X:X:?6 5.41 1 No Yes 7 0 2 1
S:S:C482 S:S:E481 3.04 1 Yes No 7 4 1 2
S:S:C482 S:S:D484 4.67 1 Yes Yes 7 8 1 2
S:S:C482 X:X:?2 11.86 1 Yes Yes 7 0 1 1
S:S:C482 X:X:?3 4.83 1 Yes Yes 7 0 1 0
S:S:C482 X:X:?6 3.8 1 Yes Yes 7 0 1 1
S:S:D484 X:X:?6 6.49 1 Yes Yes 8 0 2 1
X:X:?1 X:X:?2 27.17 1 Yes Yes 0 0 1 1
X:X:?1 X:X:?3 6.32 1 Yes Yes 0 0 1 0
X:X:?1 X:X:?4 6.63 1 Yes Yes 0 0 1 1
X:X:?2 X:X:?3 20.99 1 Yes Yes 0 0 1 0
X:X:?2 X:X:?4 5.16 1 Yes Yes 0 0 1 1
X:X:?2 X:X:?5 5.16 1 Yes Yes 0 0 1 2
X:X:?2 X:X:?6 5.16 1 Yes Yes 0 0 1 1
X:X:?3 X:X:?4 16.8 1 Yes Yes 0 0 0 1
X:X:?3 X:X:?6 16.8 1 Yes Yes 0 0 0 1
X:X:?3 X:X:?7 2.85 1 Yes Yes 0 0 0 1
X:X:?4 X:X:?5 15.84 1 Yes Yes 0 0 1 2
X:X:?4 X:X:?6 6.16 1 Yes Yes 0 0 1 1
X:X:?4 X:X:?7 5.6 1 Yes Yes 0 0 1 1
X:X:?4 X:X:?8 4.4 1 Yes Yes 0 0 1 2
X:X:?5 X:X:?6 15.84 1 Yes Yes 0 0 2 1
X:X:?5 X:X:?7 7.84 1 Yes Yes 0 0 2 1
X:X:?5 X:X:?8 8.8 1 Yes Yes 0 0 2 2
X:X:?6 X:X:?7 19.04 1 Yes Yes 0 0 1 1
X:X:?6 X:X:?8 4.4 1 Yes Yes 0 0 1 2
X:X:?7 X:X:?8 20.16 1 Yes Yes 0 0 1 2
X:X:?7 X:X:?9 6.99 1 Yes Yes 0 0 1 2
X:X:?8 X:X:?9 13.73 1 Yes Yes 0 0 2 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.43
Average Nodes In Shell21.00
Average Hubs In Shell15.00
Average Links In Shell53.00
Average Links Mediated by Hubs In Shell52.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of DAL in 7M3G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D215 S:S:R172 9.53 1 Yes Yes 6 4 2 2
R:R:D215 X:X:?5 4.33 1 Yes Yes 6 0 2 1
R:R:E241 R:R:H254 3.69 1 Yes No 5 3 2 2
R:R:E241 X:X:?8 7.4 1 Yes Yes 5 0 2 1
R:R:S244 R:R:S247 4.89 1 No Yes 4 2 2 2
R:R:S244 X:X:?5 4.79 1 No Yes 4 0 2 1
R:R:E251 R:R:S247 4.31 1 Yes Yes 4 2 2 2
R:R:S247 X:X:?5 7.18 1 Yes Yes 2 0 2 1
R:R:E251 X:X:?1 5.97 1 Yes Yes 4 0 2 2
R:R:E251 X:X:?4 6.34 1 Yes Yes 4 0 2 1
R:R:E251 X:X:?5 12.68 1 Yes Yes 4 0 2 1
R:R:H254 X:X:?4 7.18 1 No Yes 3 0 2 1
S:S:E191 S:S:R172 8.14 1 Yes Yes 3 4 1 2
S:S:R172 X:X:?5 4.84 1 Yes Yes 4 0 2 1
S:S:R172 X:X:?6 4.84 1 Yes Yes 4 0 2 1
S:S:R172 X:X:?8 7.75 1 Yes Yes 4 0 2 1
S:S:R172 X:X:?9 3.02 1 Yes Yes 4 0 2 1
S:S:D484 S:S:S175 5.89 1 Yes No 8 8 2 2
S:S:S175 X:X:?6 5.99 1 No Yes 8 0 2 1
S:S:D484 S:S:N189 5.39 1 Yes No 8 8 2 2
S:S:N189 X:X:?6 9.85 1 No Yes 8 0 2 1
S:S:E191 S:S:K225 17.55 1 Yes Yes 3 3 1 1
S:S:E191 X:X:?6 8.45 1 Yes Yes 3 0 1 1
S:S:E191 X:X:?7 9.41 1 Yes Yes 3 0 1 0
S:S:E191 X:X:?8 3.17 1 Yes Yes 3 0 1 1
S:S:E191 X:X:?9 6.59 1 Yes Yes 3 0 1 1
S:S:A194 S:S:K225 3.21 0 No Yes 7 3 2 1
S:S:E228 S:S:K225 2.7 1 No Yes 3 3 2 1
S:S:E229 S:S:K225 9.45 0 No Yes 5 3 2 1
S:S:K225 X:X:?7 11.45 1 Yes Yes 3 0 1 0
S:S:K225 X:X:?9 10.53 1 Yes Yes 3 0 1 1
S:S:E228 X:X:?8 9.51 1 No Yes 3 0 2 1
S:S:E228 X:X:?9 3.3 1 No Yes 3 0 2 1
S:S:D480 S:S:D484 9.31 1 No Yes 7 8 2 2
S:S:D480 X:X:?6 5.41 1 No Yes 7 0 2 1
S:S:C482 S:S:D484 4.67 1 Yes Yes 7 8 2 2
S:S:C482 X:X:?2 11.86 1 Yes Yes 7 0 2 2
S:S:C482 X:X:?3 4.83 1 Yes Yes 7 0 2 1
S:S:C482 X:X:?6 3.8 1 Yes Yes 7 0 2 1
S:S:D484 X:X:?6 6.49 1 Yes Yes 8 0 2 1
X:X:?1 X:X:?2 27.17 1 Yes Yes 0 0 2 2
X:X:?1 X:X:?3 6.32 1 Yes Yes 0 0 2 1
X:X:?1 X:X:?4 6.63 1 Yes Yes 0 0 2 1
X:X:?2 X:X:?3 20.99 1 Yes Yes 0 0 2 1
X:X:?2 X:X:?4 5.16 1 Yes Yes 0 0 2 1
X:X:?2 X:X:?5 5.16 1 Yes Yes 0 0 2 1
X:X:?2 X:X:?6 5.16 1 Yes Yes 0 0 2 1
X:X:?3 X:X:?4 16.8 1 Yes Yes 0 0 1 1
X:X:?3 X:X:?6 16.8 1 Yes Yes 0 0 1 1
X:X:?3 X:X:?7 2.85 1 Yes Yes 0 0 1 0
X:X:?4 X:X:?5 15.84 1 Yes Yes 0 0 1 1
X:X:?4 X:X:?6 6.16 1 Yes Yes 0 0 1 1
X:X:?4 X:X:?7 5.6 1 Yes Yes 0 0 1 0
X:X:?4 X:X:?8 4.4 1 Yes Yes 0 0 1 1
X:X:?5 X:X:?6 15.84 1 Yes Yes 0 0 1 1
X:X:?5 X:X:?7 7.84 1 Yes Yes 0 0 1 0
X:X:?5 X:X:?8 8.8 1 Yes Yes 0 0 1 1
X:X:?6 X:X:?7 19.04 1 Yes Yes 0 0 1 0
X:X:?6 X:X:?8 4.4 1 Yes Yes 0 0 1 1
X:X:?7 X:X:?8 20.16 1 Yes Yes 0 0 0 1
X:X:?7 X:X:?9 6.99 1 Yes Yes 0 0 0 1
X:X:?8 X:X:?9 13.73 1 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub8.00
Average Interaction Strength10.42
Average Nodes In Shell26.00
Average Hubs In Shell18.00
Average Links In Shell62.00
Average Links Mediated by Hubs In Shell62.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7PIU A Peptide Melanocortin MC4 Homo Sapiens Setmelanotide - Gs/Beta1/Gamma2 2.58 2021-11-17 doi.org/10.1038/s41422-021-00569-8

A 2D representation of the interactions of DAL in 7PIU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?3 L:L:H4 14.35 0 No Yes 0 0 0 1
L:L:?3 R:R:I104 5.79 0 No No 0 4 0 1
L:L:H4 R:R:F51 22.63 15 Yes Yes 0 6 1 2
L:L:H4 R:R:T101 6.85 15 Yes No 0 6 1 2
L:L:H4 R:R:N285 5.1 15 Yes No 0 4 1 2
R:R:F51 R:R:T101 9.08 15 Yes No 6 6 2 2
R:R:F51 R:R:N285 3.62 15 Yes No 6 4 2 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub1.00
Average Interaction Strength10.07
Average Nodes In Shell6.00
Average Hubs In Shell2.00
Average Links In Shell7.00
Average Links Mediated by Hubs In Shell6.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7S1M B1 Peptide Glucagon GLP-1 Homo Sapiens Exendin-4-D-Ala - Gs/Beta1/Gamma2 2.41 2022-01-05 doi.org/10.1038/s41589-021-00945-w

A 2D representation of the interactions of DAL in 7S1M
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:E3 L:L:H1 4.92 2 Yes Yes 0 0 1 1
L:L:?4 L:L:H1 10.44 2 Yes Yes 0 0 0 1
L:L:H1 R:R:Q234 6.18 2 Yes Yes 0 7 1 1
L:L:H1 R:R:V237 15.22 2 Yes No 0 6 1 2
L:L:H1 R:R:Y241 4.36 2 Yes Yes 0 8 1 2
L:L:H1 R:R:W306 3.17 2 Yes Yes 0 6 1 1
L:L:H1 R:R:I313 3.98 2 Yes No 0 7 1 2
L:L:?4 L:L:E3 4.03 2 Yes Yes 0 0 0 1
L:L:E3 R:R:Y152 8.98 2 Yes Yes 0 7 1 2
L:L:E3 R:R:R190 9.3 2 Yes Yes 0 8 1 2
L:L:E3 R:R:V194 5.7 2 Yes No 0 7 1 2
L:L:E3 R:R:L388 3.98 2 Yes No 0 7 1 2
L:L:?4 L:L:T5 4.49 2 Yes Yes 0 0 0 1
L:L:?4 L:L:T7 5.98 2 Yes No 0 0 0 1
L:L:?4 R:R:Q234 4.05 2 Yes Yes 0 7 0 1
L:L:?4 R:R:W306 4.62 2 Yes Yes 0 6 0 1
L:L:T5 R:R:D372 14.45 2 Yes No 0 5 1 2
L:L:T5 R:R:R380 3.88 2 Yes Yes 0 5 1 2
L:L:T5 R:R:L384 5.9 2 Yes No 0 5 1 2
L:L:T7 R:R:K197 6.01 0 No Yes 0 6 1 2
R:R:R190 R:R:Y152 5.14 2 Yes Yes 8 7 2 2
R:R:V194 R:R:Y152 10.09 2 No Yes 7 7 2 2
R:R:R190 R:R:V237 14.38 2 Yes No 8 6 2 2
R:R:R190 R:R:Y241 13.38 2 Yes Yes 8 8 2 2
R:R:K197 R:R:M233 4.32 2 Yes No 6 6 2 2
R:R:M233 R:R:Q234 4.08 0 No Yes 6 7 2 1
R:R:Q234 R:R:W284 4.38 2 Yes Yes 7 8 1 2
R:R:Q234 R:R:W306 6.57 2 Yes Yes 7 6 1 1
R:R:I309 R:R:Q234 9.61 2 Yes Yes 7 7 2 1
R:R:I313 R:R:Y241 7.25 2 No Yes 7 8 2 2
R:R:I309 R:R:W284 14.09 2 Yes Yes 7 8 2 2
R:R:N300 R:R:W306 25.99 0 No Yes 6 6 2 1
R:R:M303 R:R:W306 3.49 0 No Yes 5 6 2 1
R:R:I309 R:R:W306 5.87 2 Yes Yes 7 6 2 1
R:R:R310 R:R:W306 26.99 0 No Yes 6 6 2 1
R:R:D372 R:R:R380 9.53 2 No Yes 5 5 2 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.60
Average Nodes In Shell24.00
Average Hubs In Shell13.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y66 A Peptide Complement Peptide C5A1 Homo Sapiens BM213 - Gi1/Beta1/Gamma2 2.9 2023-03-01 doi.org/10.1038/s41422-023-00779-2

A 2D representation of the interactions of DAL in 7Y66
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:L4 L:L:R8 7.29 0 No Yes 0 0 2 1
L:L:?7 L:L:R8 6.18 0 No Yes 0 0 0 1
L:L:?7 R:R:I116 2.9 0 No No 0 6 0 1
L:L:?7 R:R:L117 7.04 0 No No 0 4 0 1
L:L:R8 R:R:Y258 13.38 0 Yes Yes 0 7 1 2
L:L:R8 R:R:T261 3.88 0 Yes No 0 4 1 2
L:L:R8 R:R:G262 6 0 Yes No 0 5 1 2
L:L:R8 R:R:D282 9.53 0 Yes Yes 0 4 1 2
R:R:A88 R:R:I116 3.25 0 No No 6 6 2 1
R:R:I116 R:R:Y290 2.42 0 No Yes 6 7 1 2
R:R:L117 R:R:Y121 10.55 0 No No 4 7 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.37
Average Nodes In Shell12.00
Average Hubs In Shell4.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell7.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8EFQ A Peptide Opioid MOP Homo Sapiens DAMGO - Gi1/Beta1/Gamma2 3.3 2022-11-09 doi.org/10.1016/j.cell.2022.09.041

A 2D representation of the interactions of DAL in 8EFQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 10.73 2 Yes Yes 0 0 0 1
L:L:Y1 R:R:M153 7.18 2 Yes Yes 0 7 1 2
L:L:Y1 R:R:V238 3.79 2 Yes No 0 5 1 2
L:L:Y1 R:R:I298 3.63 2 Yes No 0 6 1 1
L:L:Y1 R:R:H299 14.16 2 Yes Yes 0 7 1 2
L:L:Y1 R:R:V302 6.31 2 Yes No 0 5 1 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 0 1
L:L:?2 L:L:?4 2.44 2 Yes Yes 0 0 0 1
L:L:?2 R:R:I298 5.81 2 Yes No 0 6 0 1
L:L:?2 R:R:W320 5.79 2 Yes Yes 0 4 0 1
L:L:?2 R:R:I324 7.26 2 Yes Yes 0 5 0 1
L:L:?4 L:L:G3 10.36 2 Yes No 0 0 1 1
L:L:G3 R:R:Q126 3.29 2 No Yes 0 6 1 2
L:L:?4 L:L:?5 27.45 2 Yes No 0 0 1 2
L:L:?4 R:R:Q126 9.21 2 Yes Yes 0 6 1 2
L:L:?4 R:R:N129 3.56 2 Yes No 0 4 1 2
L:L:?4 R:R:V145 3.87 2 Yes Yes 0 5 1 2
R:R:I324 R:R:Y77 9.67 2 Yes Yes 5 7 1 2
R:R:I324 R:R:Q126 6.86 2 Yes Yes 5 6 1 2
R:R:Q126 R:R:Y328 6.76 2 Yes Yes 6 7 2 2
R:R:H299 R:R:M153 2.63 2 Yes Yes 7 7 2 2
R:R:C323 R:R:I298 4.91 0 No No 6 6 2 1
R:R:K305 R:R:Y301 7.17 2 No Yes 3 5 2 2
R:R:Q316 R:R:Y301 5.64 2 Yes Yes 3 5 2 2
R:R:W320 R:R:Y301 14.47 2 Yes Yes 4 5 1 2
R:R:K305 R:R:W320 8.12 2 No Yes 3 4 2 1
R:R:Q316 R:R:W320 8.76 2 Yes Yes 3 4 2 1
R:R:I324 R:R:Y328 2.42 2 Yes Yes 5 7 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.50
Average Nodes In Shell21.00
Average Hubs In Shell13.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F7S A Peptide Opioid DOP Homo Sapiens Deltorphin - Gi1/Beta1/Gamma2 3 2022-12-14 doi.org/10.1016/j.cell.2022.12.026

A 2D representation of the interactions of DAL in 8F7S
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:H301 R:R:Y56 13.07 16 Yes No 4 7 2 2
R:R:I304 R:R:Y56 6.04 0 No No 5 7 1 2
L:L:F3 R:R:Q105 10.54 5 Yes Yes 0 5 1 2
R:R:C198 R:R:W114 6.53 5 Yes Yes 9 8 2 2
L:L:F3 R:R:W114 5.01 5 Yes Yes 0 8 1 2
L:L:F3 R:R:V124 2.62 5 Yes No 0 5 1 2
R:R:C198 R:R:L125 3.17 5 Yes No 9 5 2 2
R:R:L125 R:R:L200 2.77 5 No Yes 5 4 2 2
L:L:F3 R:R:L125 4.87 5 Yes No 0 5 1 2
L:L:Y1 R:R:Y129 6.95 0 Yes No 0 5 1 2
L:L:E4 R:R:Y129 6.73 0 Yes No 0 5 1 2
L:L:Y1 R:R:M132 8.38 0 Yes No 0 8 1 2
L:L:F3 R:R:C198 5.59 5 Yes Yes 0 9 1 2
L:L:E4 R:R:L200 5.3 0 Yes Yes 0 4 1 2
R:R:K214 R:R:V281 4.55 19 Yes No 5 6 2 2
L:L:E4 R:R:K214 9.45 0 Yes Yes 0 5 1 2
L:L:Y1 R:R:V217 5.05 0 Yes No 0 5 1 2
L:L:Y1 R:R:H278 3.27 0 Yes Yes 0 7 1 2
L:L:Y1 R:R:V281 2.52 0 Yes No 0 6 1 2
L:L:V5 R:R:W284 6.13 0 No No 0 4 1 2
R:R:I304 R:R:L300 4.28 0 No Yes 5 5 1 2
L:L:V5 R:R:L300 2.98 0 No Yes 0 5 1 2
L:L:V6 R:R:L300 2.98 0 Yes Yes 0 5 1 2
L:L:V6 R:R:H301 2.77 0 Yes Yes 0 4 1 2
L:L:?2 R:R:I304 8.71 0 Yes No 0 5 0 1
L:L:?2 L:L:Y1 4.77 0 Yes Yes 0 0 0 1
L:L:?2 L:L:F3 2.48 0 Yes Yes 0 0 0 1
L:L:?2 L:L:E4 2.7 0 Yes Yes 0 0 0 1
L:L:?2 L:L:V5 7.58 0 Yes No 0 0 0 1
L:L:?2 L:L:V6 4.55 0 Yes Yes 0 0 0 1
L:L:?8 L:L:F3 18.09 5 Yes Yes 0 0 2 1
L:L:?8 L:L:V6 7.37 5 Yes Yes 0 0 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.13
Average Nodes In Shell24.00
Average Hubs In Shell14.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8I95 A Peptide Complement Peptide C3A Homo Sapiens EP54 - Go/Beta1/Gamma2 2.88 2023-10-18 doi.org/10.1016/j.cell.2023.09.020

A 2D representation of the interactions of DAL in 8I95
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M6 L:L:P7 3.35 0 Yes No 0 0 2 2
L:L:M6 L:L:R10 3.72 0 Yes Yes 0 0 2 1
L:L:P7 R:R:D417 6.44 2 No Yes 0 8 2 2
L:L:P7 R:R:I421 3.39 2 No Yes 0 4 2 1
L:L:?9 L:L:L8 4.22 2 Yes Yes 0 0 0 1
L:L:L8 R:R:H81 9 2 Yes Yes 0 7 1 2
L:L:L8 R:R:W88 5.69 2 Yes Yes 0 9 1 2
L:L:L8 R:R:I98 4.28 2 Yes Yes 0 8 1 2
L:L:L8 R:R:P99 6.57 2 Yes No 0 8 1 2
L:L:L8 R:R:I102 4.28 2 Yes Yes 0 8 1 1
L:L:?9 L:L:R10 6.18 2 Yes Yes 0 0 0 1
L:L:?9 R:R:I102 4.36 2 Yes Yes 0 8 0 1
L:L:?9 R:R:M106 4.31 2 Yes No 0 9 0 1
L:L:?9 R:R:Y393 7.15 2 Yes Yes 0 9 0 1
L:L:?9 R:R:I421 5.81 2 Yes Yes 0 4 0 1
L:L:R10 R:R:R340 6.4 2 Yes Yes 0 9 1 2
L:L:R10 R:R:Y393 14.4 2 Yes Yes 0 9 1 1
L:L:R10 R:R:D417 17.87 2 Yes Yes 0 8 1 2
L:L:R10 R:R:I421 7.52 2 Yes Yes 0 4 1 1
R:R:I102 R:R:S74 4.64 2 Yes No 8 9 1 2
R:R:H81 R:R:W88 7.41 2 Yes Yes 7 9 2 2
R:R:I98 R:R:W88 4.7 2 Yes Yes 8 9 2 2
R:R:I98 R:R:P99 11.85 2 Yes No 8 8 2 2
R:R:I102 R:R:I98 5.89 2 Yes Yes 8 8 1 2
R:R:M106 R:R:W390 5.82 2 No Yes 9 9 1 2
R:R:M106 R:R:Y393 3.59 2 No Yes 9 9 1 1
R:R:F107 R:R:R340 7.48 2 Yes Yes 8 9 2 2
R:R:F107 R:R:Y393 5.16 2 Yes Yes 8 9 2 1
R:R:R340 R:R:Y393 6.17 2 Yes Yes 9 9 2 1
R:R:W390 R:R:Y393 4.82 2 Yes Yes 9 9 2 1
R:R:H394 R:R:W390 4.23 2 Yes Yes 9 9 2 2
R:R:A424 R:R:W390 7.78 2 No Yes 9 9 2 2
R:R:H394 R:R:Y393 9.8 2 Yes Yes 9 9 2 1
R:R:A424 R:R:Y393 4 2 No Yes 9 9 2 1
R:R:D417 R:R:I421 5.6 2 Yes Yes 8 4 2 1
L:L:R10 R:R:G397 1.5 2 Yes No 0 8 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.34
Average Nodes In Shell21.00
Average Hubs In Shell15.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8I9A A Peptide Complement Peptide C3A Homo Sapiens EP54 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.57 2023-10-18 doi.org/10.1016/j.cell.2023.09.020

A 2D representation of the interactions of DAL in 8I9A
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M6 L:L:R10 6.2 0 Yes Yes 0 0 2 1
L:L:?9 L:L:L8 2.82 1 Yes Yes 0 0 0 1
L:L:L8 R:R:H81 5.14 1 Yes No 0 7 1 2
L:L:L8 R:R:I98 9.99 1 Yes Yes 0 8 1 2
L:L:L8 R:R:P99 4.93 1 Yes No 0 8 1 2
L:L:L8 R:R:I102 4.28 1 Yes Yes 0 8 1 2
L:L:?9 L:L:R10 14.83 1 Yes Yes 0 0 0 1
L:L:?9 R:R:V103 3.03 1 Yes Yes 0 5 0 1
L:L:?9 R:R:Y393 3.58 1 Yes Yes 0 9 0 1
L:L:?9 R:R:I421 11.61 1 Yes No 0 4 0 1
L:L:R10 R:R:R340 5.33 1 Yes Yes 0 9 1 2
L:L:R10 R:R:Y393 13.38 1 Yes Yes 0 9 1 1
L:L:R10 R:R:G397 6 1 Yes No 0 8 1 2
L:L:R10 R:R:D417 10.72 1 Yes Yes 0 8 1 2
R:R:I98 R:R:P99 6.77 1 Yes No 8 8 2 2
R:R:I102 R:R:I98 4.42 1 Yes Yes 8 8 2 2
R:R:I102 R:R:M106 2.92 1 Yes Yes 8 9 2 2
R:R:M106 R:R:V103 4.56 1 Yes Yes 9 5 2 1
R:R:C154 R:R:V103 3.42 0 No Yes 8 5 2 1
R:R:R340 R:R:V103 7.85 1 Yes Yes 9 5 2 1
R:R:M106 R:R:W390 4.65 1 Yes Yes 9 9 2 2
R:R:F107 R:R:R340 14.97 1 Yes Yes 8 9 2 2
R:R:F107 R:R:W390 5.01 1 Yes Yes 8 9 2 2
R:R:F107 R:R:Y393 5.16 1 Yes Yes 8 9 2 1
R:R:R340 R:R:Y393 3.09 1 Yes Yes 9 9 2 1
R:R:W390 R:R:Y393 7.72 1 Yes Yes 9 9 2 1
R:R:H394 R:R:Y393 13.07 0 No Yes 9 9 2 1
R:R:D417 R:R:I421 5.6 1 Yes No 8 4 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.17
Average Nodes In Shell19.00
Average Hubs In Shell13.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8K9K A Peptide Opioid MOP Homo Sapiens DAMGO - Gi3/Beta1/Gamma1 2.98 2024-05-29 doi.org/10.1038/s41467-024-47792-6

A 2D representation of the interactions of DAL in 8K9K
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 15.5 5 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y150 5.96 0 Yes No 0 4 1 2
L:L:Y1 R:R:M153 7.18 0 Yes Yes 0 7 1 2
L:L:Y1 R:R:V238 6.31 0 Yes No 0 5 1 2
L:L:Y1 R:R:V302 10.09 0 Yes No 0 5 1 2
L:L:?2 L:L:G3 6.96 5 Yes No 0 0 0 1
L:L:?2 L:L:?5 7.59 5 Yes No 0 0 0 1
L:L:?2 R:R:W320 12.74 5 Yes Yes 0 4 0 1
L:L:?2 R:R:I324 4.36 5 Yes No 0 5 0 1
L:L:?4 L:L:G3 10.36 5 Yes No 0 0 2 1
L:L:?4 L:L:?5 22.6 5 Yes No 0 0 2 1
L:L:?4 R:R:T220 5.1 5 Yes No 0 4 2 2
L:L:?5 R:R:T220 3.97 5 No No 0 4 1 2
R:R:H321 R:R:Y77 9.8 5 Yes No 4 7 2 2
R:R:I324 R:R:Y77 6.04 5 No No 5 7 1 2
R:R:K305 R:R:Y301 4.78 5 No Yes 3 5 2 2
R:R:W320 R:R:Y301 8.68 5 Yes Yes 4 5 1 2
R:R:K305 R:R:W320 11.6 5 No Yes 3 4 2 1
R:R:H321 R:R:W320 5.29 5 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 8.22 5 No Yes 5 4 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.43
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8K9L A Peptide Opioid MOP Homo Sapiens DAMGO BMS-986122 Gi3/Beta1/Gamma1 3.05 2024-05-29 doi.org/10.1038/s41467-024-47792-6

A 2D representation of the interactions of DAL in 8K9L
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 14.31 6 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y150 3.97 0 Yes No 0 4 1 2
L:L:Y1 R:R:M153 4.79 0 Yes No 0 7 1 2
L:L:Y1 R:R:V238 6.31 0 Yes No 0 5 1 2
L:L:Y1 R:R:V302 3.79 0 Yes No 0 5 1 2
L:L:?2 L:L:G3 6.96 6 Yes No 0 0 0 1
L:L:?2 L:L:?4 4.87 6 Yes Yes 0 0 0 1
L:L:?2 L:L:?5 3.8 6 Yes No 0 0 0 1
L:L:?2 R:R:W320 13.9 6 Yes Yes 0 4 0 1
L:L:?4 L:L:G3 8.88 6 Yes No 0 0 1 1
L:L:?4 L:L:?5 20.99 6 Yes No 0 0 1 1
L:L:?4 R:R:Q126 14.97 6 Yes No 0 6 1 2
L:L:?4 R:R:V145 3.87 6 Yes No 0 5 1 2
L:L:?4 R:R:I146 8.64 6 Yes Yes 0 4 1 2
L:L:?4 R:R:C219 4.12 6 Yes Yes 0 9 1 2
L:L:?5 R:R:T220 3.97 6 No No 0 4 1 2
R:R:C219 R:R:I146 3.27 6 Yes Yes 9 4 2 2
R:R:K305 R:R:Y301 4.78 6 No Yes 3 5 2 2
R:R:W320 R:R:Y301 6.75 6 Yes Yes 4 5 1 2
R:R:K305 R:R:W320 8.12 6 No Yes 3 4 2 1
R:R:I324 R:R:W320 4.7 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.77
Average Nodes In Shell18.00
Average Hubs In Shell7.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y72 A Peptide Opioid MOP Homo Sapiens Peptide BMS-986122 Gi1/Beta1/Gamma2 2.65 2025-08-06 To be published

A 2D representation of the interactions of DAL in 8Y72
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q126 R:R:Y77 2.25 2 Yes Yes 6 7 2 2
R:R:H321 R:R:Y77 15.24 2 Yes Yes 4 7 2 2
R:R:I324 R:R:Y77 7.25 2 Yes Yes 5 7 1 2
R:R:F125 R:R:W135 4.01 2 Yes Yes 6 8 2 2
R:R:F125 R:R:V145 7.87 2 Yes No 6 5 2 2
L:L:?4 R:R:F125 2.11 2 Yes Yes 0 6 1 2
R:R:Q126 R:R:Y328 11.27 2 Yes Yes 6 7 2 2
L:L:G3 R:R:Q126 3.29 2 No Yes 0 6 1 2
L:L:?4 R:R:Q126 8.06 2 Yes Yes 0 6 1 2
R:R:V145 R:R:W135 6.13 2 No Yes 5 8 2 2
L:L:?4 R:R:W135 5.91 2 Yes Yes 0 8 1 2
L:L:?4 R:R:V145 12.89 2 Yes No 0 5 1 2
R:R:I146 R:R:Y150 3.63 2 Yes Yes 4 4 2 2
R:R:I146 R:R:L221 5.71 2 Yes Yes 4 4 2 2
L:L:?4 R:R:I146 16.05 2 Yes Yes 0 4 1 2
R:R:D149 R:R:Y150 5.75 2 Yes Yes 5 4 2 2
R:R:D149 R:R:Y328 8.05 2 Yes Yes 5 7 2 2
L:L:?4 R:R:D149 7.05 2 Yes Yes 0 5 1 2
R:R:L221 R:R:Y150 2.34 2 Yes Yes 4 4 2 2
L:L:?4 R:R:Y150 2.03 2 Yes Yes 0 4 1 2
L:L:?5 R:R:Y150 3.16 2 Yes Yes 0 4 1 2
R:R:M153 R:R:V238 3.04 2 Yes Yes 7 5 2 2
R:R:M153 R:R:W295 4.65 2 Yes Yes 7 8 2 2
R:R:H299 R:R:M153 2.63 2 Yes Yes 7 7 2 2
L:L:Y1 R:R:M153 5.99 2 Yes Yes 0 7 1 2
L:L:?4 R:R:T220 5.1 2 Yes No 0 4 1 2
L:L:?5 R:R:T220 11.92 2 Yes No 0 4 1 2
L:L:?5 R:R:L221 1.87 2 Yes Yes 0 4 1 2
L:L:Y1 R:R:V238 11.36 2 Yes Yes 0 5 1 2
R:R:I298 R:R:W295 2.35 2 Yes Yes 6 8 1 2
R:R:H299 R:R:W295 6.35 2 Yes Yes 7 8 2 2
R:R:H299 R:R:I298 3.98 2 Yes Yes 7 6 2 1
R:R:I298 R:R:V302 3.07 2 Yes Yes 6 5 1 2
R:R:I298 R:R:W320 2.35 2 Yes Yes 6 4 1 1
R:R:C323 R:R:I298 3.27 0 No Yes 6 6 2 1
L:L:Y1 R:R:I298 2.42 2 Yes Yes 0 6 1 1
L:L:?2 R:R:I298 2.9 2 Yes Yes 0 6 0 1
L:L:Y1 R:R:H299 9.8 2 Yes Yes 0 7 1 2
R:R:K305 R:R:Y301 5.97 2 No Yes 3 5 2 2
R:R:W320 R:R:Y301 6.75 2 Yes Yes 4 5 1 2
R:R:V302 R:R:W320 2.45 2 Yes Yes 5 4 2 1
L:L:Y1 R:R:V302 3.79 2 Yes Yes 0 5 1 2
R:R:K305 R:R:W320 6.96 2 No Yes 3 4 2 1
R:R:H321 R:R:W320 5.29 2 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 10.57 2 Yes Yes 5 4 1 1
L:L:?2 R:R:W320 11.59 2 Yes Yes 0 4 0 1
R:R:I324 R:R:Y328 2.42 2 Yes Yes 5 7 1 2
L:L:?2 R:R:I324 11.61 2 Yes Yes 0 5 0 1
L:L:?2 L:L:Y1 9.54 2 Yes Yes 0 0 0 1
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 0 1
L:L:?2 L:L:?4 7.31 2 Yes Yes 0 0 0 1
L:L:?2 L:L:?5 1.9 2 Yes Yes 0 0 0 1
L:L:?4 L:L:G3 4.44 2 Yes No 0 0 1 1
L:L:?4 L:L:?5 29.06 2 Yes Yes 0 0 1 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.40
Average Nodes In Shell28.00
Average Hubs In Shell23.00
Average Links In Shell54.00
Average Links Mediated by Hubs In Shell54.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y73 A Peptide Opioid MOP Homo Sapiens Peptide MPAM-15 Gi1/Beta1/Gamma2 2.84 2025-08-06 To be published

A 2D representation of the interactions of DAL in 8Y73
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:H321 R:R:Y77 13.07 1 Yes Yes 4 7 2 2
R:R:I324 R:R:Y77 4.84 1 No Yes 5 7 1 2
L:L:?4 R:R:Q126 6.91 1 Yes No 0 6 1 2
L:L:?4 R:R:N129 3.56 1 Yes No 0 4 1 2
L:L:?4 R:R:V145 3.87 1 Yes Yes 0 5 1 2
L:L:?4 R:R:I146 7.41 1 Yes Yes 0 4 1 2
L:L:Y1 R:R:Y150 3.97 1 Yes No 0 4 1 2
L:L:Y1 R:R:M153 3.59 1 Yes No 0 7 1 2
R:R:K235 R:R:V302 3.04 1 Yes No 4 5 2 2
L:L:Y1 R:R:K235 3.58 1 Yes Yes 0 4 1 2
L:L:Y1 R:R:V238 11.36 1 Yes No 0 5 1 2
L:L:Y1 R:R:H299 5.44 1 Yes Yes 0 7 1 2
R:R:K305 R:R:Y301 4.78 1 No Yes 3 5 2 2
R:R:W320 R:R:Y301 4.82 1 Yes Yes 4 5 1 2
L:L:Y1 R:R:V302 6.31 1 Yes No 0 5 1 2
R:R:K305 R:R:W320 8.12 1 No Yes 3 4 2 1
R:R:H321 R:R:W320 4.23 1 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 7.05 1 No Yes 5 4 1 1
L:L:?2 R:R:W320 5.79 1 Yes Yes 0 4 0 1
L:L:?2 R:R:I324 5.81 1 Yes No 0 5 0 1
L:L:?2 L:L:Y1 11.92 1 Yes Yes 0 0 0 1
L:L:?2 L:L:G3 6.96 1 Yes No 0 0 0 1
L:L:?2 L:L:?4 7.31 1 Yes Yes 0 0 0 1
L:L:?4 L:L:G3 4.44 1 Yes No 0 0 1 1
L:L:?4 L:L:?5 22.6 1 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.56
Average Nodes In Shell21.00
Average Hubs In Shell11.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KUG A Peptide Complement Peptide C5A1 Homo Sapiens EP67 - Go/Beta1/Gamma2 3.07 2025-11-26 10.1101/2025.05.26.656101

A 2D representation of the interactions of DAL in 9KUG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M6 L:L:P7 3.35 2 Yes Yes 0 0 2 2
L:L:M6 L:L:R10 2.48 2 Yes Yes 0 0 2 1
L:L:?8 L:L:P7 4.35 0 No Yes 0 0 1 2
L:L:P7 L:L:R10 4.32 2 Yes Yes 0 0 2 1
L:L:P7 R:R:D282 4.83 2 Yes Yes 0 4 2 2
L:L:?8 L:L:?9 24.87 0 No Yes 0 0 1 0
L:L:?8 R:R:W102 5.03 0 No Yes 0 8 1 2
L:L:?9 L:L:R10 7.41 2 Yes Yes 0 0 0 1
L:L:?9 R:R:L92 7.04 2 Yes No 0 6 0 1
L:L:?9 R:R:I116 2.9 2 Yes No 0 6 0 1
L:L:?9 R:R:L117 2.82 2 Yes No 0 4 0 1
L:L:?9 R:R:Y290 7.15 2 Yes Yes 0 7 0 1
L:L:R10 R:R:L117 3.64 2 Yes No 0 4 1 1
L:L:R10 R:R:Y258 8.23 2 Yes Yes 0 7 1 2
L:L:R10 R:R:T261 3.88 2 Yes Yes 0 4 1 2
L:L:R10 R:R:G262 3 2 Yes No 0 5 1 2
L:L:R10 R:R:D282 10.72 2 Yes Yes 0 4 1 2
L:L:R10 R:R:V286 2.62 2 Yes No 0 5 1 2
R:R:F44 R:R:L92 7.31 0 Yes No 7 6 2 1
R:R:F44 R:R:Y290 3.09 0 Yes Yes 7 7 2 1
R:R:A88 R:R:I116 3.25 0 No No 6 6 2 1
R:R:I116 R:R:Y290 2.42 2 No Yes 6 7 1 1
R:R:L117 R:R:Y121 5.86 2 No No 4 7 1 2
R:R:M120 R:R:Y258 3.59 2 No Yes 7 7 2 2
R:R:M120 R:R:Y290 4.79 2 No Yes 7 7 2 1
R:R:V286 R:R:Y290 3.79 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.70
Average Nodes In Shell19.00
Average Hubs In Shell10.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KXS A Peptide Complement Peptide C5A1 Mus Musculus EP67 - Go/Beta1/Gamma2 3.31 2025-11-26 10.1101/2025.05.26.656101

A 2D representation of the interactions of DAL in 9KXS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?8 L:L:P7 2.9 3 Yes No 0 0 1 2
L:L:P7 R:R:N283 4.89 0 No No 0 4 2 2
L:L:?8 L:L:?9 21.14 3 Yes Yes 0 0 1 0
L:L:?8 R:R:L92 8.56 3 Yes No 0 6 1 2
L:L:?8 R:R:P113 5.8 3 Yes No 0 5 1 2
L:L:?8 R:R:R175 2.15 3 Yes Yes 0 4 1 2
L:L:?9 L:L:R10 6.18 3 Yes Yes 0 0 0 1
L:L:?9 R:R:I116 2.9 3 Yes No 0 6 0 1
L:L:?9 R:R:Y259 4.77 3 Yes Yes 0 7 0 1
L:L:R10 R:R:Y259 7.2 3 Yes Yes 0 7 1 1
L:L:R10 R:R:T262 3.88 3 Yes Yes 0 5 1 2
L:L:R10 R:R:N283 13.26 3 Yes No 0 4 1 2
L:L:R10 R:R:C286 2.79 3 Yes No 0 7 1 2
R:R:A88 R:R:I116 3.25 0 No No 7 6 2 1
R:R:P113 R:R:R175 7.21 3 No Yes 5 4 2 2
R:R:W256 R:R:Y259 4.82 3 Yes Yes 8 7 2 1
R:R:A290 R:R:W256 5.19 3 No Yes 8 8 2 2
R:R:A290 R:R:Y259 2.67 3 No Yes 8 7 2 1
R:R:C286 R:R:T262 6.76 3 No Yes 7 5 2 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.75
Average Nodes In Shell15.00
Average Hubs In Shell7.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KZ2 A Peptide Complement Peptide C3A Homo Sapiens EP67 - Go/Beta1/Gamma2 3.43 2025-11-26 10.1101/2025.05.26.656101

A 2D representation of the interactions of DAL in 9KZ2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M6 L:L:R10 6.2 0 No Yes 0 0 2 1
L:L:?8 L:L:P7 5.8 7 Yes No 0 0 1 2
L:L:?8 L:L:?9 24.87 7 Yes Yes 0 0 1 0
L:L:?8 R:R:S78 7.96 7 Yes No 0 8 1 2
L:L:?8 R:R:I98 3.78 7 Yes Yes 0 8 1 2
L:L:?8 R:R:P99 2.9 7 Yes No 0 8 1 2
L:L:?8 R:R:I102 5.04 7 Yes Yes 0 8 1 2
L:L:?9 L:L:R10 6.18 0 Yes Yes 0 0 0 1
L:L:?9 R:R:V103 3.03 0 Yes No 0 5 0 1
L:L:?9 R:R:I421 2.9 0 Yes No 0 4 0 1
L:L:R10 R:R:R340 5.33 0 Yes Yes 0 9 1 2
L:L:R10 R:R:Y393 16.46 0 Yes Yes 0 9 1 2
L:L:R10 R:R:G397 6 0 Yes No 0 8 1 2
L:L:R10 R:R:D417 10.72 0 Yes No 0 8 1 2
R:R:I98 R:R:P99 10.16 7 Yes No 8 8 2 2
R:R:I102 R:R:I98 5.89 7 Yes Yes 8 8 2 2
R:R:F107 R:R:V103 5.24 0 No No 8 5 2 1
R:R:F107 R:R:R340 6.41 0 No Yes 8 9 2 2
R:R:I421 R:R:Y393 3.63 0 No Yes 4 9 1 2
R:R:D417 R:R:I421 2.8 0 No No 8 4 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.24
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KZ8 A Peptide Complement Peptide C3A Mus Musculus EP67 - Go/Beta1/Gamma2 3.3 2025-11-26 10.1101/2025.05.26.656101

A 2D representation of the interactions of DAL in 9KZ8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?8 L:L:P7 2.9 0 Yes No 0 0 1 2
L:L:P7 R:R:D410 6.44 2 No Yes 0 9 2 2
L:L:?8 L:L:?9 21.14 0 Yes Yes 0 0 1 0
L:L:?8 R:R:S78 6.63 0 Yes No 0 8 1 2
L:L:?8 R:R:P99 5.8 0 Yes No 0 8 1 2
L:L:?8 R:R:I102 7.56 0 Yes Yes 0 8 1 2
L:L:?9 L:L:R10 4.94 2 Yes Yes 0 0 0 1
L:L:?9 R:R:I103 2.9 2 Yes Yes 0 5 0 1
L:L:?9 R:R:Y386 3.58 2 Yes Yes 0 8 0 1
L:L:?9 R:R:I414 8.71 2 Yes No 0 5 0 1
L:L:R10 R:R:R333 4.26 2 Yes Yes 0 9 1 2
L:L:R10 R:R:Y386 11.32 2 Yes Yes 0 8 1 1
L:L:R10 R:R:G390 6 2 Yes No 0 8 1 2
L:L:R10 R:R:D410 9.53 2 Yes Yes 0 9 1 2
R:R:F107 R:R:I103 5.02 2 Yes Yes 8 5 2 1
R:R:C154 R:R:I103 3.27 0 No Yes 7 5 2 1
R:R:I103 R:R:V157 4.61 2 Yes No 5 8 1 2
R:R:I103 R:R:R333 3.76 2 Yes Yes 5 9 1 2
R:R:F107 R:R:R333 7.48 2 Yes Yes 8 9 2 2
R:R:R333 R:R:Y386 4.12 2 Yes Yes 9 8 2 1
R:R:W383 R:R:Y386 5.79 2 Yes Yes 9 8 2 1
R:R:A417 R:R:W383 3.89 2 No Yes 9 9 2 2
R:R:H387 R:R:Y386 3.27 0 No Yes 9 8 2 1
R:R:I414 R:R:Y386 6.04 2 No Yes 5 8 1 1
R:R:A417 R:R:Y386 4 2 No Yes 9 8 2 1
L:L:R10 R:R:L393 2.43 2 Yes No 0 1 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.25
Average Nodes In Shell20.00
Average Hubs In Shell10.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9UMJ A Peptide Complement Peptide C3A Mus Musculus EP54 - Go/Beta1/Gamma2 3.38 2025-11-26 10.1101/2025.05.26.656101

A 2D representation of the interactions of DAL in 9UMJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?9 L:L:L8 4.22 2 Yes Yes 0 0 0 1
L:L:L8 R:R:H81 7.71 2 Yes Yes 0 8 1 2
L:L:L8 R:R:W88 2.28 2 Yes Yes 0 9 1 2
L:L:L8 R:R:R161 7.29 2 Yes Yes 0 8 1 2
L:L:?9 L:L:R10 4.94 2 Yes Yes 0 0 0 1
L:L:?9 R:R:I102 2.9 2 Yes Yes 0 8 0 1
L:L:?9 R:R:I103 2.9 2 Yes Yes 0 5 0 1
L:L:?9 R:R:M106 4.31 2 Yes Yes 0 9 0 1
L:L:?9 R:R:Y386 7.15 2 Yes Yes 0 8 0 1
L:L:?9 R:R:I414 7.26 2 Yes No 0 5 0 1
L:L:R10 R:R:Y174 2.06 2 Yes Yes 0 8 1 2
L:L:R10 R:R:R333 2.13 2 Yes Yes 0 9 1 2
L:L:R10 R:R:Y386 15.43 2 Yes Yes 0 8 1 1
L:L:R10 R:R:V389 2.62 2 Yes No 0 4 1 2
L:L:R10 R:R:G390 4.5 2 Yes No 0 8 1 2
L:L:R10 R:R:D410 9.53 2 Yes No 0 9 1 2
L:L:R10 R:R:S413 2.64 2 Yes No 0 6 1 2
R:R:I102 R:R:S74 4.64 2 Yes No 8 9 1 2
R:R:N105 R:R:S74 5.96 2 Yes No 9 9 2 2
R:R:H81 R:R:W88 4.23 2 Yes Yes 8 9 2 2
R:R:I98 R:R:W88 5.87 0 Yes Yes 8 9 2 2
R:R:I102 R:R:I98 2.94 2 Yes Yes 8 8 1 2
R:R:I102 R:R:N105 2.83 2 Yes Yes 8 9 1 2
R:R:I102 R:R:M106 4.37 2 Yes Yes 8 9 1 1
R:R:F107 R:R:I103 2.51 2 Yes Yes 8 5 2 1
R:R:C154 R:R:I103 3.27 0 No Yes 7 5 2 1
R:R:I103 R:R:V157 7.68 2 Yes No 5 8 1 2
R:R:I103 R:R:R333 10.02 2 Yes Yes 5 9 1 2
R:R:M106 R:R:N105 2.8 2 Yes Yes 9 9 1 2
R:R:M106 R:R:W383 2.33 2 Yes Yes 9 9 1 2
R:R:F107 R:R:R333 7.48 2 Yes Yes 8 9 2 2
R:R:V157 R:R:Y174 6.31 0 No Yes 8 8 2 2
R:R:R333 R:R:Y386 2.06 2 Yes Yes 9 8 2 1
R:R:W383 R:R:Y386 3.86 2 Yes Yes 9 8 2 1
R:R:H387 R:R:W383 3.17 2 Yes Yes 9 9 2 2
R:R:A417 R:R:W383 3.89 2 No Yes 9 9 2 2
R:R:H387 R:R:Y386 4.36 2 Yes Yes 9 8 2 1
R:R:S413 R:R:Y386 3.82 2 No Yes 6 8 2 1
R:R:I414 R:R:Y386 4.84 2 No Yes 5 8 1 1
R:R:A417 R:R:Y386 5.34 2 No Yes 9 8 2 1
R:R:S413 R:R:V389 8.08 2 No No 6 4 2 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength4.81
Average Nodes In Shell26.00
Average Hubs In Shell17.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9UMX A Peptide Complement Peptide C5A1 Homo Sapiens EP54 - Go/Beta1/Gamma2 3.2 2025-11-26 10.1101/2025.05.26.656101

A 2D representation of the interactions of DAL in 9UMX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:M6 L:L:R10 2.48 0 Yes Yes 0 0 2 1
L:L:?9 L:L:L8 4.22 6 Yes Yes 0 0 0 1
L:L:L8 R:R:I91 2.85 0 Yes No 0 6 1 2
L:L:L8 R:R:W102 3.42 0 Yes Yes 0 8 1 2
L:L:L8 R:R:P113 4.93 0 Yes No 0 6 1 2
L:L:?9 L:L:R10 4.94 6 Yes Yes 0 0 0 1
L:L:?9 R:R:L92 5.63 6 Yes No 0 6 0 1
L:L:?9 R:R:I116 4.36 6 Yes No 0 6 0 1
L:L:?9 R:R:Y290 3.58 6 Yes Yes 0 7 0 1
L:L:R10 R:R:L117 3.64 0 Yes No 0 4 1 2
L:L:R10 R:R:Y258 13.38 0 Yes Yes 0 7 1 2
L:L:R10 R:R:G262 3 0 Yes No 0 5 1 2
L:L:R10 R:R:D282 15.48 0 Yes No 0 4 1 2
R:R:F44 R:R:L89 2.44 6 Yes Yes 7 7 2 2
R:R:F44 R:R:L92 4.87 6 Yes No 7 6 2 1
R:R:F44 R:R:Y290 5.16 6 Yes Yes 7 7 2 1
R:R:A88 R:R:I116 3.25 0 No No 6 6 2 1
R:R:L89 R:R:Y290 2.34 6 Yes Yes 7 7 2 1
R:R:L92 R:R:Y290 3.52 6 No Yes 6 7 1 1
R:R:M120 R:R:Y258 2.39 6 No Yes 7 7 2 2
R:R:M120 R:R:Y290 3.59 6 No Yes 7 7 2 1
R:R:V286 R:R:Y258 2.52 0 No Yes 5 7 2 2
R:R:V286 R:R:Y290 6.31 0 No Yes 5 7 2 1
L:L:L8 R:R:S95 1.5 0 Yes No 0 4 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength4.55
Average Nodes In Shell20.00
Average Hubs In Shell9.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9WST A Peptide Opioid MOP Homo Sapiens DAMGO - chim(NtGi1-Gz)/Beta1/Gamma2 2.8 2025-11-26 10.1038/s41422-025-01191-8

A 2D representation of the interactions of DAL in 9WST
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 16.69 3 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y150 2.98 0 Yes No 0 4 1 2
L:L:Y1 R:R:M153 9.58 0 Yes No 0 7 1 2
L:L:Y1 R:R:V238 6.31 0 Yes No 0 5 1 2
L:L:?2 L:L:G3 6.96 3 Yes No 0 0 0 1
L:L:?2 R:R:I298 4.36 3 Yes No 0 6 0 1
L:L:?2 R:R:W320 9.27 3 Yes Yes 0 4 0 1
L:L:?2 R:R:I324 8.71 3 Yes No 0 5 0 1
L:L:?4 L:L:G3 8.88 3 Yes No 0 0 2 1
L:L:G3 R:R:Q126 3.29 3 No No 0 6 1 2
L:L:?4 R:R:Q126 9.21 3 Yes No 0 6 2 2
R:R:H321 R:R:Y77 14.16 3 Yes Yes 4 7 2 2
R:R:I324 R:R:Y77 6.04 3 No Yes 5 7 1 2
R:R:I298 R:R:V302 3.07 0 No No 6 5 1 2
R:R:C323 R:R:I298 3.27 0 No No 6 6 2 1
R:R:K305 R:R:Y301 8.36 3 No No 3 5 2 2
R:R:W320 R:R:Y301 5.79 3 Yes No 4 5 1 2
R:R:K305 R:R:W320 6.96 3 No Yes 3 4 2 1
R:R:H321 R:R:W320 7.41 3 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 7.05 3 No Yes 5 4 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.20
Average Nodes In Shell17.00
Average Hubs In Shell6.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9WSV A Peptide Opioid MOP Homo Sapiens DAMGO - Arrestin2 2.8 2025-11-26 10.1038/s41422-025-01191-8

A 2D representation of the interactions of DAL in 9WSV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 16.69 1 Yes Yes 0 0 0 1
L:L:Y1 R:R:D149 3.45 0 Yes No 0 5 1 2
L:L:Y1 R:R:Y150 4.96 0 Yes No 0 4 1 2
L:L:Y1 R:R:M153 7.18 0 Yes No 0 7 1 2
L:L:Y1 R:R:V238 5.05 0 Yes No 0 5 1 2
L:L:Y1 R:R:H299 7.62 0 Yes Yes 0 7 1 2
L:L:Y1 R:R:V302 3.79 0 Yes No 0 5 1 2
L:L:?2 L:L:G3 6.96 1 Yes No 0 0 0 1
L:L:?2 R:R:I298 5.81 1 Yes No 0 6 0 1
L:L:?2 R:R:W320 8.11 1 Yes Yes 0 4 0 1
L:L:?2 R:R:I324 8.71 1 Yes No 0 5 0 1
L:L:?4 L:L:G3 5.92 1 Yes No 0 0 2 1
L:L:G3 R:R:Q126 3.29 1 No Yes 0 6 1 2
L:L:?4 R:R:Q126 4.61 1 Yes Yes 0 6 2 2
L:L:?4 R:R:D149 7.05 1 Yes No 0 5 2 2
R:R:Q126 R:R:Y77 4.51 1 Yes Yes 6 7 2 2
R:R:H321 R:R:Y77 11.98 1 Yes Yes 4 7 2 2
R:R:I324 R:R:Y77 8.46 1 No Yes 5 7 1 2
R:R:I298 R:R:W320 3.52 1 No Yes 6 4 1 1
R:R:C323 R:R:I298 3.27 0 No No 6 6 2 1
R:R:K305 R:R:Y301 5.97 1 Yes Yes 3 5 2 2
R:R:W320 R:R:Y301 7.72 1 Yes Yes 4 5 1 2
R:R:K305 R:R:W320 5.8 1 Yes Yes 3 4 2 1
R:R:H321 R:R:W320 3.17 1 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 5.87 1 No Yes 5 4 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.26
Average Nodes In Shell19.00
Average Hubs In Shell10.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9YDP A Peptide Opioid DOP Homo Sapiens DADLE - chim(NtGi1L-Gs-CtGi1)/Beta1/Gamma2 1.95 2025-12-10 10.1101/2025.10.16.682975

A 2D representation of the interactions of DAL in 9YDP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 17.89 3 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y129 7.94 3 Yes No 0 5 1 2
L:L:Y1 R:R:M132 8.38 3 Yes Yes 0 8 1 2
L:L:Y1 R:R:V217 7.57 3 Yes No 0 5 1 2
L:L:Y1 R:R:I277 3.63 3 Yes No 0 5 1 1
L:L:Y1 R:R:H278 3.27 3 Yes Yes 0 7 1 2
L:L:Y1 R:R:V281 6.31 3 Yes No 0 6 1 2
L:L:?2 L:L:G3 6.96 3 Yes No 0 0 0 1
L:L:?2 L:L:?5 13.49 3 Yes No 0 0 0 1
L:L:?2 R:R:I277 4.36 3 Yes No 0 5 0 1
L:L:?2 R:R:I304 8.71 3 Yes Yes 0 5 0 1
L:L:G3 R:R:I304 3.53 3 No Yes 0 5 1 1
L:L:?5 R:R:K214 7.37 0 No Yes 0 5 1 2
L:L:?5 R:R:W284 19.83 0 No No 0 4 1 2
R:R:H301 R:R:Y56 13.07 3 Yes Yes 4 7 2 2
R:R:I304 R:R:Y56 9.67 3 Yes Yes 5 7 1 2
R:R:M132 R:R:V217 4.56 3 Yes No 8 5 2 2
R:R:K214 R:R:V281 7.59 0 Yes No 5 6 2 2
R:R:C303 R:R:I277 3.27 0 No No 6 5 2 1
R:R:I304 R:R:L300 7.14 3 Yes No 5 5 1 2
R:R:H301 R:R:I304 3.98 3 Yes Yes 4 5 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength10.28
Average Nodes In Shell17.00
Average Hubs In Shell8.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9YDQ A Peptide Opioid DOP Homo Sapiens DADLE MIPS3614 chim(NtGi1L-Gs-CtGi1)/Beta1/Gamma2 1.94 2025-12-10 10.1101/2025.10.16.682975

A 2D representation of the interactions of DAL in 9YDQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 16.69 2 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y129 6.95 2 Yes No 0 5 1 2
L:L:Y1 R:R:M132 8.38 2 Yes No 0 8 1 2
L:L:Y1 R:R:V217 6.31 2 Yes No 0 5 1 2
L:L:Y1 R:R:I277 3.63 2 Yes Yes 0 5 1 1
L:L:Y1 R:R:H278 3.27 2 Yes Yes 0 7 1 2
L:L:Y1 R:R:V281 3.79 2 Yes No 0 6 1 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 0 1
L:L:?2 L:L:?5 12.26 2 Yes No 0 0 0 1
L:L:?2 R:R:I277 5.81 2 Yes Yes 0 5 0 1
L:L:?2 R:R:I304 8.71 2 Yes Yes 0 5 0 1
L:L:?5 R:R:K214 11.05 0 No Yes 0 5 1 2
L:L:?5 R:R:W284 18.84 0 No Yes 0 4 1 2
R:R:H301 R:R:Y56 13.07 2 Yes Yes 4 7 2 2
R:R:I304 R:R:Y56 9.67 2 Yes Yes 5 7 1 2
R:R:K214 R:R:V281 7.59 0 Yes No 5 6 2 2
R:R:H278 R:R:I277 3.98 2 Yes Yes 7 5 2 1
R:R:C303 R:R:I277 4.91 0 No Yes 6 5 2 1
R:R:I304 R:R:L300 4.28 2 Yes No 5 5 1 2
R:R:H301 R:R:I304 3.98 2 Yes Yes 4 5 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength10.09
Average Nodes In Shell17.00
Average Hubs In Shell9.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9YDR A Peptide Opioid DOP Homo Sapiens DADLE MIPS3983 chim(NtGi1L-Gs-CtGi1)/Beta1/Gamma2 2.14 2025-12-10 10.1101/2025.10.16.682975

A 2D representation of the interactions of DAL in 9YDR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 17.89 2 Yes Yes 0 0 0 1
L:L:Y1 R:R:Y129 8.94 2 Yes No 0 5 1 2
L:L:Y1 R:R:M132 9.58 2 Yes No 0 8 1 2
L:L:Y1 R:R:V217 7.57 2 Yes No 0 5 1 2
L:L:Y1 R:R:W274 3.86 2 Yes Yes 0 8 1 2
L:L:Y1 R:R:I277 3.63 2 Yes No 0 5 1 1
L:L:Y1 R:R:H278 3.27 2 Yes Yes 0 7 1 2
L:L:Y1 R:R:V281 3.79 2 Yes No 0 6 1 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 0 1
L:L:?2 L:L:?5 12.26 2 Yes No 0 0 0 1
L:L:?2 R:R:I277 7.26 2 Yes No 0 5 0 1
L:L:?2 R:R:I304 8.71 2 Yes Yes 0 5 0 1
L:L:G3 R:R:Q105 3.29 2 No Yes 0 5 1 2
L:L:G3 R:R:I304 3.53 2 No Yes 0 5 1 1
L:L:?5 R:R:K214 12.28 0 No Yes 0 5 1 2
L:L:?5 R:R:W284 18.84 0 No Yes 0 4 1 2
R:R:H301 R:R:Y56 15.24 2 Yes Yes 4 7 2 2
R:R:I304 R:R:Y56 9.67 2 Yes Yes 5 7 1 2
R:R:M132 R:R:Y129 3.59 2 No No 8 5 2 2
R:R:M132 R:R:W274 6.98 2 No Yes 8 8 2 2
R:R:K214 R:R:V281 10.62 0 Yes No 5 6 2 2
R:R:H278 R:R:W274 5.29 2 Yes Yes 7 8 2 2
R:R:C303 R:R:I277 3.27 0 No No 6 5 2 1
R:R:I304 R:R:L300 4.28 2 Yes No 5 5 1 2
R:R:H301 R:R:I304 3.98 2 Yes Yes 4 5 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength10.62
Average Nodes In Shell19.00
Average Hubs In Shell10.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links4.96
Average Number Of Links With An Hub3.11
Average Interaction Strength8.60
Average Nodes In Shell17.84
Average Hubs In Shell9.20
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell23.62

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)