CodeMEA
NameN-METHYLPHENYLALANINE
Synonyms
Identifier
FormulaC10 H13 N O2
Molecular Weight179.216
SMILES
PubChem6951134
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6
Networks21
 missing image

This ligand is also present in the following 21 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6DDE A Peptide Opioid MOP Mus Musculus Damgo - Gi1/Beta1/Gamma2 3.5 2018-06-13 doi.org/10.1038/s41586-018-0219-7

A 2D representation of the interactions of MEA in 6DDE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:G3 6.94 1 Yes No 0 0 2 1
L:L:?2 R:R:W318 9.25 1 Yes Yes 0 5 2 2
L:L:?4 L:L:G3 8.82 1 Yes No 0 0 0 1
L:L:?4 L:L:?5 20.99 1 Yes No 0 0 0 1
L:L:?4 R:R:Q124 9.15 1 Yes No 0 6 0 1
L:L:?4 R:R:W133 3.91 1 Yes Yes 0 8 0 1
L:L:?4 R:R:I144 13.49 1 Yes Yes 0 5 0 1
L:L:?4 R:R:C217 2.73 1 Yes Yes 0 9 0 1
L:L:?5 R:R:K303 5.74 1 No No 0 4 1 2
L:L:?5 R:R:W318 6.18 1 No Yes 0 5 1 2
R:R:L121 R:R:Y75 7.03 1 Yes Yes 7 7 2 2
R:R:Q124 R:R:Y75 5.64 1 No Yes 6 7 1 2
R:R:L121 R:R:Q124 2.66 1 Yes No 7 6 2 1
R:R:F123 R:R:W133 5.01 1 No Yes 6 8 2 1
R:R:F123 R:R:F135 6.43 1 No No 6 7 2 2
R:R:F123 R:R:V143 13.11 1 No No 6 5 2 2
R:R:N127 R:R:W133 6.78 0 No Yes 6 8 2 1
R:R:F135 R:R:W133 13.03 1 No Yes 7 8 2 1
R:R:G136 R:R:W133 2.81 0 No Yes 7 8 2 1
R:R:V143 R:R:W133 7.36 1 No Yes 5 8 2 1
R:R:C217 R:R:W133 22.2 1 Yes Yes 9 8 1 1
R:R:C140 R:R:C217 7.28 0 No Yes 9 9 2 1
R:R:A206 R:R:I144 4.87 0 No Yes 4 5 2 1
R:R:C217 R:R:I144 3.27 1 Yes Yes 9 5 1 1
R:R:I144 R:R:L219 4.28 1 Yes No 5 5 1 2
R:R:K303 R:R:W318 3.48 1 No Yes 4 5 2 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.85
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6DDF A Peptide Opioid MOP Mus Musculus Damgo - Gi1/Beta1/Gamma2 3.5 2018-06-13 doi.org/10.1038/s41586-018-0219-7

A 2D representation of the interactions of MEA in 6DDF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q124 R:R:Y75 4.51 1 Yes Yes 6 7 1 2
R:R:I322 R:R:Y75 7.25 1 Yes Yes 5 7 2 2
R:R:Q124 R:R:T120 4.25 1 Yes No 6 6 1 2
R:R:F123 R:R:W133 2 1 No Yes 6 8 2 1
R:R:F123 R:R:F135 11.79 1 No Yes 6 7 2 2
R:R:F123 R:R:V143 5.24 1 No No 6 5 2 1
R:R:D147 R:R:Q124 2.61 1 Yes Yes 6 6 1 1
L:L:?4 R:R:Q124 6.86 1 Yes Yes 0 6 0 1
R:R:N127 R:R:W133 6.78 0 No Yes 6 8 2 1
R:R:F135 R:R:W133 19.04 1 Yes Yes 7 8 2 1
R:R:C140 R:R:W133 6.53 1 Yes Yes 9 8 2 1
R:R:V143 R:R:W133 7.36 1 No Yes 5 8 1 1
R:R:C217 R:R:W133 20.89 1 Yes Yes 9 8 1 1
L:L:?4 R:R:W133 4.89 1 Yes Yes 0 8 0 1
R:R:C140 R:R:I144 3.27 1 Yes Yes 9 5 2 1
R:R:C140 R:R:C217 7.28 1 Yes Yes 9 9 2 1
L:L:?4 R:R:V143 3.84 1 Yes No 0 5 0 1
R:R:I144 R:R:Y148 2.42 1 Yes Yes 5 4 1 2
R:R:A206 R:R:I144 6.5 1 No Yes 4 5 2 1
R:R:C217 R:R:I144 3.27 1 Yes Yes 9 5 1 1
R:R:I144 R:R:L219 2.85 1 Yes No 5 5 1 2
L:L:?4 R:R:I144 11.04 1 Yes Yes 0 5 0 1
R:R:D147 R:R:Y148 3.45 1 Yes Yes 6 4 1 2
R:R:D147 R:R:Y326 5.75 1 Yes No 6 7 1 2
L:L:?4 R:R:D147 3.5 1 Yes Yes 0 6 0 1
L:L:Y1 R:R:Y148 6.95 1 Yes Yes 0 4 2 2
R:R:A206 R:R:L219 3.15 1 No No 4 5 2 2
L:L:?4 R:R:C217 4.09 1 Yes Yes 0 9 0 1
R:R:I296 R:R:I322 2.94 1 Yes Yes 6 5 2 2
L:L:Y1 R:R:I296 3.63 1 Yes Yes 0 6 2 2
L:L:?2 R:R:I296 2.9 1 Yes Yes 0 6 1 2
R:R:K303 R:R:W318 3.48 1 No Yes 4 5 2 2
L:L:?5 R:R:K303 5.74 1 Yes No 0 4 1 2
L:L:?2 R:R:W318 10.4 1 Yes Yes 0 5 1 2
L:L:?5 R:R:W318 7.73 1 Yes Yes 0 5 1 2
R:R:I322 R:R:Y326 2.42 1 Yes No 5 7 2 2
L:L:?2 R:R:I322 5.79 1 Yes Yes 0 5 1 2
L:L:G3 R:R:I322 1.76 1 No Yes 0 5 1 2
L:L:?2 L:L:Y1 11.89 1 Yes Yes 0 0 1 2
L:L:?2 L:L:G3 6.94 1 Yes No 0 0 1 1
L:L:?2 L:L:?4 4.83 1 Yes Yes 0 0 1 0
L:L:?2 L:L:?5 7.63 1 Yes Yes 0 0 1 1
L:L:?4 L:L:G3 5.88 1 Yes No 0 0 0 1
L:L:?4 L:L:?5 20.99 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.32
Average Nodes In Shell25.00
Average Hubs In Shell16.00
Average Links In Shell44.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8X A Peptide Cholecystokinin CCKA Homo Sapiens NN9056 - - 3 2021-12-29 doi.org/10.1038/s41589-021-00866-8

A 2D representation of the interactions of MEA in 7F8X
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C94 R:R:M121 8.1 0 No Yes 7 7 2 1
R:R:L356 R:R:N98 9.61 1 No No 6 7 1 2
R:R:N98 R:R:Y360 15.12 0 No Yes 7 7 2 2
R:R:T118 R:R:Y176 3.75 0 No Yes 6 7 2 1
L:L:?6 R:R:M121 4.01 1 Yes Yes 0 7 1 1
L:L:?8 R:R:M121 8.5 1 Yes Yes 0 7 0 1
L:L:?9 R:R:M121 14.07 1 Yes Yes 0 7 1 1
R:R:F198 R:R:Y176 19.6 1 Yes Yes 5 7 2 1
R:R:W209 R:R:Y176 7.72 1 Yes Yes 8 7 2 1
L:L:?7 R:R:Y176 7.89 1 Yes Yes 0 7 1 1
L:L:?8 R:R:Y176 10.07 1 Yes Yes 0 7 0 1
R:R:F198 R:R:W209 4.01 1 Yes Yes 5 8 2 2
L:L:?7 R:R:F198 4.55 1 Yes Yes 0 5 1 2
R:R:H210 R:R:W209 4.23 0 Yes Yes 6 8 2 2
R:R:L213 R:R:W209 15.94 0 No Yes 7 8 2 2
R:R:H210 R:R:N333 7.65 0 Yes Yes 6 7 2 1
R:R:F330 R:R:L213 4.87 0 Yes No 7 7 1 2
R:R:F218 R:R:F330 16.08 0 No Yes 8 7 2 1
R:R:F330 R:R:W326 4.01 0 Yes Yes 7 8 1 2
R:R:I329 R:R:N333 7.08 1 No Yes 7 7 1 1
R:R:I329 R:R:L356 4.28 1 No No 7 6 1 1
L:L:?8 R:R:I329 3.68 1 Yes No 0 7 0 1
L:L:?8 R:R:F330 10.46 1 Yes Yes 0 7 0 1
L:L:W5 R:R:N333 6.78 1 Yes Yes 0 7 2 1
L:L:?7 R:R:N333 7.18 1 Yes Yes 0 7 1 1
L:L:?8 R:R:N333 5.9 1 Yes Yes 0 7 0 1
L:L:?8 R:R:L356 4.76 1 Yes No 0 6 0 1
L:L:?9 R:R:Y360 5.83 1 Yes Yes 0 7 1 2
L:L:?2 L:L:?6 8.76 1 Yes Yes 0 0 2 1
L:L:?6 L:L:W5 9.69 1 Yes Yes 0 0 1 2
L:L:?6 L:L:?7 23.48 1 Yes Yes 0 0 1 1
L:L:?6 L:L:?8 11.25 1 Yes Yes 0 0 1 0
L:L:?7 L:L:?8 34.66 1 Yes Yes 0 0 1 0
L:L:?7 L:L:?9 5.15 1 Yes Yes 0 0 1 1
L:L:?8 L:L:?9 20.71 1 Yes Yes 0 0 0 1
R:R:F330 R:R:L214 2.44 0 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength12.22
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y65 A Peptide Complement Peptide C5A1 Homo Sapiens C5a peptide - Gi1/Beta1/Gamma2 3.2 2023-03-01 doi.org/10.1038/s41422-023-00779-2

A 2D representation of the interactions of MEA in 7Y65
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 6.1 19 Yes No 0 0 0 1
L:L:?1 L:L:P3 2.84 19 Yes No 0 0 0 1
L:L:?1 R:R:V176 2.58 19 Yes No 0 4 0 1
L:L:?1 R:R:R178 18.92 19 Yes No 0 2 0 1
L:L:?1 R:R:L187 10.78 19 Yes No 0 4 0 1
L:L:?1 R:R:G189 5.92 19 Yes No 0 4 0 1
L:L:?1 R:R:D191 17.61 19 Yes No 0 4 0 1
L:L:?1 R:R:P270 2.84 19 Yes No 0 3 0 1
L:L:K2 R:R:E199 6.75 0 No No 0 4 1 2
L:L:K2 R:R:F275 8.69 0 No Yes 0 3 1 2
L:L:P3 R:R:L187 9.85 19 No No 0 4 1 1
R:R:R178 R:R:V176 9.15 19 No No 2 4 1 1
R:R:F275 R:R:P270 10.11 0 Yes No 3 3 2 1
R:R:E269 R:R:P270 1.57 0 No No 3 3 2 1
L:L:P3 R:R:H100 1.53 19 No No 0 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub0.00
Average Interaction Strength8.45
Average Nodes In Shell13.00
Average Hubs In Shell2.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y67 A Peptide Complement Peptide C5A1 Homo Sapiens C089 peptide - Gi1/Beta1/Gamma2 2.8 2023-03-01 doi.org/10.1038/s41422-023-00779-2

A 2D representation of the interactions of MEA in 7Y67
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G189 R:R:R175 4.5 0 No Yes 4 5 1 2
R:R:D191 R:R:V176 4.38 0 No No 4 4 1 2
L:L:?1 R:R:R178 5.26 0 Yes No 0 2 0 1
L:L:?1 R:R:L187 5.99 0 Yes No 0 4 0 1
L:L:?1 R:R:G189 2.96 0 Yes No 0 4 0 1
R:R:D191 R:R:S193 2.94 0 No No 4 4 1 2
L:L:?1 R:R:D191 3.52 0 Yes No 0 4 0 1
L:L:K2 R:R:E199 5.4 30 Yes No 0 4 1 2
R:R:F275 R:R:K279 7.44 30 Yes No 3 4 2 2
L:L:K2 R:R:F275 2.48 30 Yes Yes 0 3 1 2
L:L:K2 R:R:K279 2.87 30 Yes No 0 4 1 2
L:L:P3 R:R:K279 3.35 0 No No 0 4 1 2
L:L:?1 L:L:K2 9.76 0 Yes Yes 0 0 0 1
L:L:?1 L:L:P3 4.26 0 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.29
Average Nodes In Shell13.00
Average Hubs In Shell4.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8EFQ A Peptide Opioid MOP Homo Sapiens Damgo - Gi1/Beta1/Gamma2 3.3 2022-11-09 doi.org/10.1016/j.cell.2022.09.041

A 2D representation of the interactions of MEA in 8EFQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 10.73 2 Yes Yes 0 0 1 2
L:L:Y1 R:R:I298 3.63 2 Yes No 0 6 2 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 1 1
L:L:?2 L:L:?4 2.44 2 Yes Yes 0 0 1 0
L:L:?2 R:R:I298 5.81 2 Yes No 0 6 1 2
L:L:?2 R:R:W320 5.79 2 Yes Yes 0 4 1 2
L:L:?2 R:R:I324 7.26 2 Yes Yes 0 5 1 2
L:L:?4 L:L:G3 10.36 2 Yes No 0 0 0 1
L:L:G3 R:R:Q126 3.29 2 No Yes 0 6 1 1
L:L:?4 L:L:?5 27.45 2 Yes No 0 0 0 1
L:L:?4 R:R:Q126 9.21 2 Yes Yes 0 6 0 1
L:L:?4 R:R:N129 3.56 2 Yes No 0 4 0 1
L:L:?4 R:R:V145 3.87 2 Yes Yes 0 5 0 1
R:R:F125 R:R:W135 4.01 2 Yes Yes 6 8 2 2
R:R:F125 R:R:L141 2.44 2 Yes No 6 5 2 2
R:R:F125 R:R:V145 6.55 2 Yes Yes 6 5 2 1
R:R:I324 R:R:Q126 6.86 2 Yes Yes 5 6 2 1
R:R:Q126 R:R:Y328 6.76 2 Yes Yes 6 7 1 2
R:R:V145 R:R:W135 4.9 2 Yes Yes 5 8 1 2
R:R:L141 R:R:V145 2.98 2 No Yes 5 5 2 1
R:R:I324 R:R:Y328 2.42 2 Yes Yes 5 7 2 2
L:L:?5 R:R:T220 1.99 0 No No 0 4 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.48
Average Nodes In Shell16.00
Average Hubs In Shell10.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HPT A Peptide Complement Peptide C5A1 Mus Musculus C5a anaphylatoxin C-terminal peptide - Go/Beta1/Gamma2 3.39 2023-10-18 doi.org/10.1016/j.cell.2023.09.020

A 2D representation of the interactions of MEA in 8HPT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 8.54 2 No No 0 0 0 1
L:L:?1 L:L:P3 2.84 2 No Yes 0 0 0 1
L:L:K2 L:L:P3 5.02 2 No Yes 0 0 1 1
L:L:?4 L:L:P3 4.63 2 Yes Yes 0 0 2 1
L:L:P3 R:R:E280 6.29 2 Yes No 0 3 1 2
L:L:?1 R:R:E176 2.29 2 No No 0 3 0 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub1.00
Average Interaction Strength4.56
Average Nodes In Shell6.00
Average Hubs In Shell2.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8K9K A Peptide Opioid MOP Homo Sapiens Damgo - Gi3/Beta1/Gamma1 2.98 2024-05-29 doi.org/10.1038/s41467-024-47792-6

A 2D representation of the interactions of MEA in 8K9K
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:G3 6.96 5 Yes No 0 0 2 1
L:L:?2 L:L:?5 7.59 5 Yes No 0 0 2 1
L:L:?4 L:L:G3 10.36 5 Yes No 0 0 0 1
L:L:?4 L:L:?5 22.6 5 Yes No 0 0 0 1
L:L:?4 R:R:Q126 11.52 5 Yes Yes 0 6 0 1
L:L:?4 R:R:I146 8.64 5 Yes Yes 0 4 0 1
L:L:?4 R:R:D149 4.7 5 Yes Yes 0 5 0 1
L:L:?4 R:R:T220 5.1 5 Yes No 0 4 0 1
L:L:?5 R:R:T220 3.97 5 No No 0 4 1 1
R:R:Q126 R:R:T122 5.67 5 Yes Yes 6 6 1 2
R:R:D149 R:R:T122 5.78 5 Yes Yes 5 6 1 2
R:R:T122 R:R:Y328 3.75 5 Yes Yes 6 7 2 2
R:R:L123 R:R:Q126 3.99 5 Yes Yes 7 6 2 1
R:R:L123 R:R:Y328 21.1 5 Yes Yes 7 7 2 2
R:R:D149 R:R:Q126 3.92 5 Yes Yes 5 6 1 1
R:R:Q126 R:R:Y328 5.64 5 Yes Yes 6 7 1 2
R:R:I146 R:R:V204 3.07 0 Yes No 4 5 1 2
R:R:A208 R:R:I146 4.87 0 No Yes 5 4 2 1
R:R:C219 R:R:I146 3.27 22 No Yes 9 4 2 1
R:R:I146 R:R:L221 2.85 0 Yes No 4 4 1 2
R:R:D149 R:R:Y328 4.6 5 Yes Yes 5 7 1 2
R:R:D218 R:R:T220 1.45 0 No No 4 4 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength10.49
Average Nodes In Shell16.00
Average Hubs In Shell8.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8K9L A Peptide Opioid MOP Homo Sapiens Damgo BMS-986122 Gi3/Beta1/Gamma1 3.05 2024-05-29 doi.org/10.1038/s41467-024-47792-6

A 2D representation of the interactions of MEA in 8K9L
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 14.31 6 Yes Yes 0 0 1 2
L:L:?2 L:L:G3 6.96 6 Yes No 0 0 1 1
L:L:?2 L:L:?4 4.87 6 Yes Yes 0 0 1 0
L:L:?2 L:L:?5 3.8 6 Yes No 0 0 1 1
L:L:?2 R:R:W320 13.9 6 Yes Yes 0 4 1 2
L:L:?4 L:L:G3 8.88 6 Yes No 0 0 0 1
L:L:?4 L:L:?5 20.99 6 Yes No 0 0 0 1
L:L:?4 R:R:Q126 14.97 6 Yes No 0 6 0 1
L:L:?4 R:R:V145 3.87 6 Yes No 0 5 0 1
L:L:?4 R:R:I146 8.64 6 Yes Yes 0 4 0 1
L:L:?4 R:R:C219 4.12 6 Yes Yes 0 9 0 1
L:L:?5 R:R:T220 3.97 6 No No 0 4 1 2
R:R:Q126 R:R:Y77 7.89 0 No Yes 6 7 1 2
R:R:F125 R:R:V145 3.93 0 No No 6 5 2 1
R:R:C142 R:R:W135 5.22 6 No Yes 9 8 2 2
R:R:C219 R:R:W135 6.53 6 Yes Yes 9 8 1 2
R:R:C142 R:R:C219 7.28 6 No Yes 9 9 2 1
R:R:A208 R:R:I146 3.25 0 No Yes 5 4 2 1
R:R:C219 R:R:I146 3.27 6 Yes Yes 9 4 1 1
R:R:I146 R:R:L221 4.28 6 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.48
Average Nodes In Shell17.00
Average Hubs In Shell8.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y72 A Peptide Opioid MOP Homo Sapiens Peptide BMS-986122 Gi1/Beta1/Gamma2 2.65 2025-08-06 To be published

A 2D representation of the interactions of MEA in 8Y72
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L123 R:R:Y77 2.34 2 Yes Yes 7 7 2 2
R:R:Q126 R:R:Y77 2.25 2 Yes Yes 6 7 1 2
R:R:I324 R:R:Y77 7.25 2 Yes Yes 5 7 2 2
R:R:Q126 R:R:T122 4.25 2 Yes Yes 6 6 1 2
R:R:D149 R:R:T122 7.23 2 Yes Yes 5 6 1 2
R:R:T122 R:R:Y328 3.75 2 Yes Yes 6 7 2 2
R:R:L123 R:R:Q126 3.99 2 Yes Yes 7 6 2 1
R:R:L123 R:R:Y328 17.58 2 Yes Yes 7 7 2 2
R:R:F125 R:R:W135 4.01 2 Yes Yes 6 8 1 1
R:R:F125 R:R:F137 15 2 Yes Yes 6 6 1 2
R:R:F125 R:R:L141 6.09 2 Yes No 6 5 1 2
R:R:F125 R:R:V145 7.87 2 Yes No 6 5 1 1
L:L:?4 R:R:F125 2.11 2 Yes Yes 0 6 0 1
R:R:Q126 R:R:Y328 11.27 2 Yes Yes 6 7 1 2
L:L:G3 R:R:Q126 3.29 2 No Yes 0 6 1 1
L:L:?4 R:R:Q126 8.06 2 Yes Yes 0 6 0 1
R:R:N129 R:R:W135 9.04 0 No Yes 4 8 2 1
R:R:P136 R:R:W135 2.7 2 No Yes 3 8 2 1
R:R:F137 R:R:W135 20.04 2 Yes Yes 6 8 2 1
R:R:G138 R:R:W135 2.81 0 No Yes 7 8 2 1
R:R:C142 R:R:W135 7.84 2 No Yes 9 8 2 1
R:R:V145 R:R:W135 6.13 2 No Yes 5 8 1 1
R:R:I217 R:R:W135 4.7 0 Yes Yes 4 8 2 1
R:R:C219 R:R:W135 16.98 2 No Yes 9 8 2 1
L:L:?4 R:R:W135 5.91 2 Yes Yes 0 8 0 1
R:R:F137 R:R:P136 14.45 2 Yes No 6 3 2 2
R:R:F137 R:R:L141 6.09 2 Yes No 6 5 2 2
R:R:C142 R:R:I146 3.27 2 No Yes 9 4 2 1
R:R:C142 R:R:C219 7.28 2 No No 9 9 2 2
L:L:?4 R:R:V145 12.89 2 Yes No 0 5 0 1
R:R:I146 R:R:Y150 3.63 2 Yes Yes 4 4 1 1
R:R:I146 R:R:V204 3.07 2 Yes Yes 4 5 1 2
R:R:I146 R:R:L221 5.71 2 Yes Yes 4 4 1 2
L:L:?4 R:R:I146 16.05 2 Yes Yes 0 4 0 1
R:R:D149 R:R:Y150 5.75 2 Yes Yes 5 4 1 1
R:R:D149 R:R:Y328 8.05 2 Yes Yes 5 7 1 2
L:L:?4 R:R:D149 7.05 2 Yes Yes 0 5 0 1
R:R:V204 R:R:Y150 7.57 2 Yes Yes 5 4 2 1
R:R:L221 R:R:Y150 2.34 2 Yes Yes 4 4 2 1
L:L:?4 R:R:Y150 2.03 2 Yes Yes 0 4 0 1
L:L:?5 R:R:Y150 3.16 2 Yes Yes 0 4 1 1
R:R:L221 R:R:V204 4.47 2 Yes Yes 4 5 2 2
R:R:R213 R:R:T220 3.88 0 No No 2 4 2 1
L:L:?4 R:R:T220 5.1 2 Yes No 0 4 0 1
L:L:?5 R:R:T220 11.92 2 Yes No 0 4 1 1
L:L:?5 R:R:L221 1.87 2 Yes Yes 0 4 1 2
R:R:I298 R:R:W320 2.35 2 Yes Yes 6 4 2 2
L:L:Y1 R:R:I298 2.42 2 Yes Yes 0 6 2 2
L:L:?2 R:R:I298 2.9 2 Yes Yes 0 6 1 2
R:R:I324 R:R:W320 10.57 2 Yes Yes 5 4 2 2
L:L:?2 R:R:W320 11.59 2 Yes Yes 0 4 1 2
R:R:I324 R:R:Y328 2.42 2 Yes Yes 5 7 2 2
L:L:?2 R:R:I324 11.61 2 Yes Yes 0 5 1 2
L:L:?2 L:L:Y1 9.54 2 Yes Yes 0 0 1 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 1 1
L:L:?2 L:L:?4 7.31 2 Yes Yes 0 0 1 0
L:L:?2 L:L:?5 1.9 2 Yes Yes 0 0 1 1
L:L:?4 L:L:G3 4.44 2 Yes No 0 0 0 1
L:L:?4 L:L:?5 29.06 2 Yes Yes 0 0 0 1
R:R:A208 R:R:I146 1.62 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub8.00
Average Interaction Strength9.09
Average Nodes In Shell32.00
Average Hubs In Shell21.00
Average Links In Shell60.00
Average Links Mediated by Hubs In Shell58.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Y73 A Peptide Opioid MOP Homo Sapiens Peptide MPAM-15 Gi1/Beta1/Gamma2 2.84 2025-08-06 To be published

A 2D representation of the interactions of MEA in 8Y73
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q126 R:R:T122 4.25 1 No Yes 6 6 1 2
R:R:T122 R:R:V145 3.17 1 Yes Yes 6 5 2 1
R:R:T122 R:R:Y328 3.75 1 Yes Yes 6 7 2 2
R:R:F125 R:R:W135 3.01 1 No Yes 6 8 2 2
R:R:F125 R:R:V145 6.55 1 No Yes 6 5 2 1
R:R:Q126 R:R:Y328 10.15 1 No Yes 6 7 1 2
L:L:?4 R:R:Q126 6.91 1 Yes No 0 6 0 1
R:R:N129 R:R:W135 4.52 0 No Yes 4 8 1 2
L:L:?4 R:R:N129 3.56 1 Yes No 0 4 0 1
R:R:C142 R:R:W135 7.84 1 Yes Yes 9 8 2 2
R:R:V145 R:R:W135 4.9 1 Yes Yes 5 8 1 2
R:R:C219 R:R:W135 19.59 1 No Yes 9 8 2 2
R:R:C142 R:R:I146 3.27 1 Yes Yes 9 4 2 1
R:R:C142 R:R:C219 7.28 1 Yes No 9 9 2 2
L:L:?4 R:R:V145 3.87 1 Yes Yes 0 5 0 1
R:R:I146 R:R:V204 3.07 1 Yes Yes 4 5 1 2
R:R:C219 R:R:I146 3.27 1 No Yes 9 4 2 1
R:R:I146 R:R:L221 2.85 1 Yes No 4 4 1 2
L:L:?4 R:R:I146 7.41 1 Yes Yes 0 4 0 1
R:R:L221 R:R:V204 2.98 1 No Yes 4 5 2 2
L:L:?5 R:R:T220 11.92 0 No No 0 4 1 2
R:R:I324 R:R:W320 7.05 1 No Yes 5 4 2 2
L:L:?2 R:R:W320 5.79 1 Yes Yes 0 4 1 2
L:L:?2 R:R:I324 5.81 1 Yes No 0 5 1 2
L:L:?2 L:L:Y1 11.92 1 Yes Yes 0 0 1 2
L:L:?2 L:L:G3 6.96 1 Yes No 0 0 1 1
L:L:?2 L:L:?4 7.31 1 Yes Yes 0 0 1 0
L:L:?4 L:L:G3 4.44 1 Yes No 0 0 0 1
L:L:?4 L:L:?5 22.6 1 Yes No 0 0 0 1
R:R:A208 R:R:I146 1.62 0 No Yes 5 4 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.01
Average Nodes In Shell21.00
Average Hubs In Shell11.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.76
Average Number Of Links With An Hub2.71
Average Interaction Strength8.65
Average Nodes In Shell17.24
Average Hubs In Shell7.67
Average Links In Shell23.48
Average Links Mediated by Hubs In Shell20.48

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)