CodeMEA
NameN-METHYLPHENYLALANINE
Synonyms
Identifier(2S)-2-(methylamino)-3-phenyl-propanoic acid
FormulaC10 H13 N O2
Molecular Weight179.216
SMILESCN[C@@H](Cc1ccccc1)C(=O)O
PubChem6951134
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6
Networks7
 missing image

This ligand is also present in the following 7 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6DDE A Peptide Opioid MOP Mus musculus Damgo - Gi1/Beta1/Gamma2 3.5 2018-06-13 10.1038/s41586-018-0219-7

A 2D representation of the interactions of MEA in 6DDE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q124 R:R:Y75 5.64 0 No Yes 6 7 1 2
R:R:F123 R:R:W133 5.01 18 No Yes 6 8 2 1
R:R:F123 R:R:F135 6.43 18 No No 6 7 2 2
R:R:F123 R:R:V143 13.11 18 No No 6 5 2 2
L:L:?4 R:R:Q124 9.1 0 Yes No 0 6 0 1
R:R:N127 R:R:W133 6.78 0 No Yes 6 8 2 1
R:R:F135 R:R:W133 13.03 18 No Yes 7 8 2 1
R:R:V143 R:R:W133 7.36 18 No Yes 5 8 2 1
R:R:C217 R:R:W133 22.2 0 No Yes 9 8 2 1
L:L:?4 R:R:W133 3.89 0 Yes Yes 0 8 0 1
R:R:A206 R:R:I144 4.87 0 No Yes 4 5 2 1
R:R:C217 R:R:I144 3.27 0 No Yes 9 5 2 1
R:R:I144 R:R:L219 4.28 0 Yes No 5 5 1 2
L:L:?4 R:R:I144 13.41 0 Yes Yes 0 5 0 1
R:R:K303 R:R:W318 3.48 2 No Yes 4 5 2 2
L:L:?5 R:R:K303 5.76 2 No No 0 4 1 2
L:L:?2 R:R:W318 9.27 2 Yes Yes 0 5 2 2
L:L:?5 R:R:W318 6.21 2 No Yes 0 5 1 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 2 1
L:L:?4 L:L:G3 8.77 0 Yes No 0 0 0 1
L:L:?4 L:L:?5 20.94 0 Yes No 0 0 0 1
R:R:G136 R:R:W133 2.81 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength11.22
Average Nodes In Shell18.00
Average Hubs In Shell6.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6DDF A Peptide Opioid MOP Mus musculus Damgo - Gi1/Beta1/Gamma2 3.5 2018-06-13 10.1038/s41586-018-0219-7

A 2D representation of the interactions of MEA in 6DDF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q124 R:R:Y75 4.51 1 Yes Yes 6 7 1 2
R:R:I322 R:R:Y75 7.25 1 Yes Yes 5 7 2 2
R:R:Q124 R:R:T120 4.25 1 Yes No 6 6 1 2
R:R:F123 R:R:W133 2 1 No Yes 6 8 2 1
R:R:F123 R:R:F135 11.79 1 No Yes 6 7 2 2
R:R:F123 R:R:V143 5.24 1 No No 6 5 2 1
R:R:D147 R:R:Q124 2.61 1 Yes Yes 6 6 1 1
L:L:?4 R:R:Q124 6.82 1 Yes Yes 0 6 0 1
R:R:N127 R:R:W133 6.78 0 No Yes 6 8 2 1
R:R:F135 R:R:W133 19.04 1 Yes Yes 7 8 2 1
R:R:C140 R:R:W133 6.53 1 Yes Yes 9 8 2 1
R:R:V143 R:R:W133 7.36 1 No Yes 5 8 1 1
R:R:C217 R:R:W133 20.89 1 Yes Yes 9 8 1 1
L:L:?4 R:R:W133 4.86 1 Yes Yes 0 8 0 1
R:R:C140 R:R:I144 3.27 1 Yes Yes 9 5 2 1
R:R:C140 R:R:C217 7.28 1 Yes Yes 9 9 2 1
L:L:?4 R:R:V143 3.82 1 Yes No 0 5 0 1
R:R:I144 R:R:Y148 2.42 1 Yes Yes 5 4 1 2
R:R:A206 R:R:I144 6.5 1 No Yes 4 5 2 1
R:R:C217 R:R:I144 3.27 1 Yes Yes 9 5 1 1
R:R:I144 R:R:L219 2.85 1 Yes No 5 5 1 2
L:L:?4 R:R:I144 10.97 1 Yes Yes 0 5 0 1
R:R:D147 R:R:Y148 3.45 1 Yes Yes 6 4 1 2
R:R:D147 R:R:Y326 5.75 1 Yes No 6 7 1 2
L:L:?4 R:R:D147 3.48 1 Yes Yes 0 6 0 1
L:L:Y1 R:R:Y148 6.95 1 Yes Yes 0 4 2 2
R:R:A206 R:R:L219 3.15 1 No No 4 5 2 2
L:L:?4 R:R:C217 4.07 1 Yes Yes 0 9 0 1
R:R:I296 R:R:I322 2.94 1 Yes Yes 6 5 2 2
L:L:Y1 R:R:I296 3.63 1 Yes Yes 0 6 2 2
L:L:?2 R:R:I296 2.9 1 Yes Yes 0 6 1 2
R:R:K303 R:R:W318 3.48 1 No Yes 4 5 2 2
L:L:?5 R:R:K303 5.76 1 Yes No 0 4 1 2
L:L:?2 R:R:W318 10.43 1 Yes Yes 0 5 1 2
L:L:?5 R:R:W318 7.76 1 Yes Yes 0 5 1 2
R:R:I322 R:R:Y326 2.42 1 Yes No 5 7 2 2
L:L:?2 R:R:I322 5.81 1 Yes Yes 0 5 1 2
L:L:?2 L:L:Y1 11.93 1 Yes Yes 0 0 1 2
L:L:?2 L:L:G3 6.96 1 Yes No 0 0 1 1
L:L:?2 L:L:?4 4.81 1 Yes Yes 0 0 1 0
L:L:?2 L:L:?5 7.67 1 Yes Yes 0 0 1 1
L:L:?4 L:L:G3 5.84 1 Yes No 0 0 0 1
L:L:?4 L:L:?5 20.94 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.29
Average Nodes In Shell25.00
Average Hubs In Shell16.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8X A Peptide Cholecystokinin CCKA Homo sapiens NN9056 - - 3 2021-12-29 10.1038/s41589-021-00866-8

A 2D representation of the interactions of MEA in 7F8X
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C94 R:R:M121 8.1 0 No Yes 7 7 2 1
R:R:L356 R:R:N98 9.61 1 No No 6 7 1 2
R:R:N98 R:R:Y360 15.12 0 No Yes 7 7 2 2
R:R:T118 R:R:Y176 3.75 0 No Yes 6 7 2 1
L:L:?6 R:R:M121 4.01 1 Yes Yes 0 7 1 1
L:L:?8 R:R:M121 8.45 1 Yes Yes 0 7 0 1
L:L:?9 R:R:M121 14.09 1 Yes Yes 0 7 1 1
R:R:F198 R:R:Y176 19.6 1 Yes Yes 5 7 2 1
R:R:W209 R:R:Y176 7.72 1 Yes Yes 8 7 2 1
L:L:?7 R:R:Y176 7.89 1 Yes Yes 0 7 1 1
L:L:?8 R:R:Y176 10.01 1 Yes Yes 0 7 0 1
R:R:F198 R:R:W209 4.01 1 Yes Yes 5 8 2 2
L:L:?7 R:R:F198 4.55 1 Yes Yes 0 5 1 2
R:R:H210 R:R:W209 4.23 0 Yes Yes 6 8 2 2
R:R:L213 R:R:W209 15.94 0 No Yes 7 8 2 2
R:R:H210 R:R:N333 7.65 0 Yes Yes 6 7 2 1
R:R:F330 R:R:L213 4.87 0 Yes No 7 7 1 2
R:R:F218 R:R:F330 16.08 0 No Yes 8 7 2 1
R:R:F330 R:R:W326 4.01 0 Yes Yes 7 8 1 2
R:R:I329 R:R:N333 7.08 1 No Yes 7 7 1 1
R:R:I329 R:R:L356 4.28 1 No No 7 6 1 1
L:L:?8 R:R:I329 3.66 1 Yes No 0 7 0 1
L:L:?8 R:R:F330 10.4 1 Yes Yes 0 7 0 1
L:L:W5 R:R:N333 6.78 1 Yes Yes 0 7 2 1
L:L:?7 R:R:N333 7.18 1 Yes Yes 0 7 1 1
L:L:?8 R:R:N333 5.86 1 Yes Yes 0 7 0 1
L:L:?8 R:R:L356 4.73 1 Yes No 0 6 0 1
L:L:?9 R:R:Y360 5.84 1 Yes Yes 0 7 1 2
L:L:?2 L:L:?6 8.76 1 Yes Yes 0 0 2 1
L:L:?6 L:L:W5 9.69 1 Yes Yes 0 0 1 2
L:L:?6 L:L:?7 23.47 1 Yes Yes 0 0 1 1
L:L:?6 L:L:?8 11.18 1 Yes Yes 0 0 1 0
L:L:?7 L:L:?8 34.46 1 Yes Yes 0 0 1 0
L:L:?7 L:L:?9 5.16 1 Yes Yes 0 0 1 1
L:L:?8 L:L:?9 20.62 1 Yes Yes 0 0 0 1
R:R:F330 R:R:L214 2.44 0 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength12.15
Average Nodes In Shell23.00
Average Hubs In Shell15.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y65 A Peptide Complement peptide C5A1 Homo Sapiens C5a peptide - Gi1/Beta1/Gamma2 3.2  2023-03-01 10.1038/s41422-023-00779-2

A 2D representation of the interactions of MEA in 7Y65
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 6.02 19 Yes No 0 0 0 1
L:L:?1 L:L:P3 2.81 19 Yes No 0 0 0 1
L:L:?1 R:R:V176 2.55 19 Yes No 0 4 0 1
L:L:?1 R:R:R178 18.68 19 Yes No 0 2 0 1
L:L:?1 R:R:L187 10.64 19 Yes No 0 4 0 1
L:L:?1 R:R:G189 5.84 19 Yes No 0 4 0 1
L:L:?1 R:R:D191 17.39 19 Yes No 0 4 0 1
L:L:?1 R:R:P270 2.81 19 Yes No 0 3 0 1
L:L:K2 R:R:E199 6.75 0 No No 0 4 1 2
L:L:K2 R:R:F275 8.69 0 No Yes 0 3 1 2
L:L:P3 R:R:L187 9.85 19 No No 0 4 1 1
R:R:R178 R:R:V176 9.15 19 No No 2 4 1 1
R:R:F275 R:R:P270 10.11 0 Yes No 3 3 2 1
R:R:E269 R:R:P270 1.57 0 No No 3 3 2 1
L:L:P3 R:R:H100 1.53 19 No No 0 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub0.00
Average Interaction Strength8.34
Average Nodes In Shell13.00
Average Hubs In Shell2.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y67 A Peptide Complement peptide C5A1 Homo Sapiens C089 peptide - Gi1/Beta1/Gamma2 2.8  2023-03-01 10.1038/s41422-023-00779-2

A 2D representation of the interactions of MEA in 7Y67
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:G189 R:R:R175 4.5 0 No Yes 4 5 1 2
R:R:D191 R:R:V176 4.38 0 No No 4 4 1 2
L:L:?1 R:R:R178 5.19 0 Yes No 0 2 0 1
L:L:?1 R:R:L187 5.91 0 Yes No 0 4 0 1
L:L:?1 R:R:G189 2.92 0 Yes No 0 4 0 1
R:R:D191 R:R:S193 2.94 0 No No 4 4 1 2
L:L:?1 R:R:D191 3.48 0 Yes No 0 4 0 1
L:L:K2 R:R:E199 5.4 30 Yes No 0 4 1 2
R:R:F275 R:R:K279 7.44 30 Yes No 3 4 2 2
L:L:K2 R:R:F275 2.48 30 Yes Yes 0 3 1 2
L:L:K2 R:R:K279 2.87 30 Yes No 0 4 1 2
L:L:P3 R:R:K279 3.35 0 No No 0 4 1 2
L:L:?1 L:L:K2 9.64 0 Yes Yes 0 0 0 1
L:L:?1 L:L:P3 4.21 0 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.23
Average Nodes In Shell13.00
Average Hubs In Shell4.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8EFQ A Peptide Opioid MOP Homo sapiens Damgo - Gi1/Beta1/Gamma2 3.3  2022-11-09 10.1016/j.cell.2022.09.041

A 2D representation of the interactions of MEA in 8EFQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:Y1 10.73 2 Yes Yes 0 0 1 2
L:L:Y1 R:R:I298 3.63 2 Yes No 0 6 2 2
L:L:?2 L:L:G3 6.96 2 Yes No 0 0 1 1
L:L:?2 L:L:?4 2.41 2 Yes Yes 0 0 1 0
L:L:?2 R:R:I298 5.81 2 Yes No 0 6 1 2
L:L:?2 R:R:W320 5.79 2 Yes Yes 0 4 1 2
L:L:?2 R:R:I324 7.26 2 Yes Yes 0 5 1 2
L:L:?4 L:L:G3 10.23 2 Yes No 0 0 0 1
L:L:G3 R:R:Q126 3.29 2 No Yes 0 6 1 1
L:L:?4 R:R:Q126 9.1 2 Yes Yes 0 6 0 1
L:L:?4 R:R:N129 3.52 2 Yes No 0 4 0 1
L:L:?4 R:R:V145 3.82 2 Yes Yes 0 5 0 1
L:L:?4 L:L:?5 27.39 2 Yes No 0 0 0 1
R:R:F125 R:R:W135 4.01 2 Yes Yes 6 8 2 2
R:R:F125 R:R:L141 2.44 2 Yes No 6 5 2 2
R:R:F125 R:R:V145 6.55 2 Yes Yes 6 5 2 1
R:R:I324 R:R:Q126 6.86 2 Yes Yes 5 6 2 1
R:R:Q126 R:R:Y328 6.76 2 Yes Yes 6 7 1 2
R:R:V145 R:R:W135 4.9 2 Yes Yes 5 8 1 2
R:R:L141 R:R:V145 2.98 2 No Yes 5 5 2 1
R:R:I324 R:R:Y328 2.42 2 Yes Yes 5 7 2 2
L:L:?5 R:R:T220 2.01 0 No No 0 4 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.41
Average Nodes In Shell16.00
Average Hubs In Shell10.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HPT A Peptide Complement peptide C5a1 Mus Musculus C5a anaphylatoxin C-terminal peptide - Go/Beta1/Gamma2 3.39 2023-10-18 10.1016/j.cell.2023.09.020

A 2D representation of the interactions of MEA in 8HPT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 L:L:K2 8.43 0 No No 0 0 0 1
L:L:K2 L:L:P3 5.02 0 No No 0 0 1 2
L:L:?1 R:R:E176 2.26 0 No No 0 3 0 1
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.34
Average Nodes In Shell4.00
Average Hubs In Shell0.00
Average Links In Shell3.00
Average Links Mediated by Hubs In Shell0.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links6.43
Average Number Of Links With An Hub2.86
Average Interaction Strength8.43
Average Nodes In Shell16.00
Average Hubs In Shell7.57
Average Links In Shell22.14
Average Links Mediated by Hubs In Shell19.43

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)