psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A325	R:R:Y77	4	No	No	0	6	7
2	R:R:T329	R:R:V80	4.76	No	No	0	5	7
3	R:R:C332	R:R:V80	5.12	No	No	0	8	7
4	R:R:C81	R:R:L123	6.35	No	No	0	6	7
5	R:R:F86	R:R:V82	5.24	No	No	0	5	6
6	R:R:C332	R:R:V83	3.42	No	No	0	8	5
7	R:R:L85	R:R:T120	7.37	No	No	0	6	5
8	R:R:F86	R:R:F89	4.29	No	No	0	5	4
9	R:R:G87	R:R:P335	4.06	No	No	0	8	9
10	R:R:D116	R:R:N88	2.69	No	Yes	0	9	9
11	R:R:A117	R:R:N88	4.69	No	Yes	0	7	9
12	R:R:N88	R:R:P335	6.52	Yes	No	0	9	9
13	R:R:F349	R:R:L90	4.87	Yes	No	0	6	6
14	R:R:F349	R:R:V91	2.62	Yes	No	0	6	9
15	R:R:F110	R:R:M92	9.95	No	No	0	6	7
16	R:R:R97	R:R:Y93	18.52	No	No	0	5	4
17	R:R:F352	R:R:Y93	5.16	No	No	0	7	4
18	R:R:M101	R:R:V94	3.04	Yes	No	0	7	7
19	R:R:F345	R:R:V94	2.62	Yes	No	0	8	7
20	R:R:F110	R:R:I95	3.77	No	No	0	6	7
21	R:R:F345	R:R:I95	2.51	Yes	No	0	8	7
22	R:R:K100	R:R:Y98	9.55	No	No	0	6	4
23	R:R:M101	R:R:Y98	8.38	Yes	No	0	7	4
24	R:R:M101	R:R:N106	2.8	Yes	No	0	7	8
25	R:R:C348	R:R:M101	3.24	No	Yes	0	6	7
26	R:R:I107	R:R:K102	5.82	No	No	4	5	7
27	R:R:K102	R:R:P183	11.71	No	No	0	7	1
28	R:R:K102	R:R:K187	5.75	No	No	4	7	2
29	R:R:N106	R:R:T103	5.85	No	No	0	8	7
30	R:R:A104	R:R:R181	2.77	No	Yes	0	5	7
31	R:R:R167	R:R:T105	10.35	Yes	No	0	9	8
32	R:R:I107	R:R:K187	2.91	No	No	4	5	2
33	R:R:I107	R:R:N190	4.25	No	No	0	5	7
34	R:R:T162	R:R:Y108	4.99	No	Yes	1	7	7
35	R:R:M163	R:R:Y108	5.99	No	Yes	0	9	7
36	R:R:D166	R:R:Y108	8.05	No	Yes	1	8	7
37	R:R:I189	R:R:Y108	3.63	No	Yes	1	5	7
38	R:R:I109	R:R:M163	2.92	No	No	0	8	9
39	R:R:I109	R:R:Y338	9.67	No	Yes	0	8	9
40	R:R:N111	R:R:T159	8.77	No	Yes	0	9	8
41	R:R:N111	R:R:N190	14.98	No	No	0	9	7
42	R:R:N111	R:R:W194	9.04	No	No	0	9	9
43	R:R:L112	R:R:S156	3	No	No	0	9	9
44	R:R:L112	R:R:T159	4.42	No	Yes	0	9	8
45	R:R:L112	R:R:L160	5.54	No	No	0	9	8
46	R:R:L114	R:R:L118	2.77	No	No	0	7	7
47	R:R:A115	R:R:T155	3.36	No	Yes	0	8	7
48	R:R:D116	R:R:S331	5.89	No	No	0	9	9
49	R:R:D116	R:R:N334	5.39	No	No	0	9	9
50	R:R:L118	R:R:S121	3	No	No	0	7	5
51	R:R:A119	R:R:N152	6.25	No	No	0	7	8
52	R:R:S331	R:R:T120	3.2	No	No	0	9	5
53	R:R:Q126	R:R:T122	9.92	No	Yes	5	6	6
54	R:R:T122	R:R:V145	7.93	Yes	No	5	6	5
55	R:R:I148	R:R:T122	4.56	No	Yes	0	5	6
56	R:R:L123	R:R:Y328	5.86	No	No	0	7	7
57	R:R:F125	R:R:F137	8.57	No	Yes	0	6	6
58	R:R:Q126	R:R:V145	4.3	No	No	5	6	5
59	R:R:Q126	R:R:Y328	5.64	No	No	0	6	7
60	R:R:M132	R:R:V128	3.04	No	No	0	4	3
61	R:R:G133	R:R:N129	3.39	No	No	0	2	4
62	R:R:H321	R:R:Y130	8.71	No	No	0	4	5
63	R:R:S216	R:R:T134	3.2	No	No	0	1	5
64	R:R:I217	R:R:T134	4.56	No	No	0	4	5
65	R:R:P136	R:R:W135	5.4	No	Yes	2	3	8
66	R:R:F137	R:R:W135	7.02	Yes	Yes	2	6	8
67	R:R:G138	R:R:W135	2.81	No	Yes	0	7	8
68	R:R:C142	R:R:W135	6.53	No	Yes	2	9	8
69	R:R:T210	R:R:W135	2.43	Yes	Yes	2	4	8
70	R:R:F137	R:R:P136	5.78	Yes	No	2	6	3
71	R:R:F137	R:R:L141	6.09	Yes	No	0	6	5
72	R:R:T139	R:R:T209	4.71	No	No	0	3	5
73	R:R:T139	R:R:T210	10.99	No	Yes	0	3	4
74	R:R:I140	R:R:L141	4.28	No	No	0	1	5
75	R:R:C142	R:R:T210	3.38	No	Yes	2	9	4
76	R:R:C142	R:R:C219	7.28	No	No	0	9	9
77	R:R:K143	R:R:M205	10.08	No	No	0	6	5
78	R:R:A208	R:R:K143	3.21	No	No	0	5	6
79	R:R:A208	R:R:I146	3.25	No	No	0	5	4
80	R:R:S147	R:R:Y151	2.54	No	Yes	0	6	5
81	R:R:M205	R:R:S147	6.13	No	No	0	5	6
82	R:R:D149	R:R:Y328	3.45	No	No	0	5	7
83	R:R:V204	R:R:Y150	17.66	No	No	0	5	4
84	R:R:L234	R:R:Y150	3.52	No	No	0	6	4
85	R:R:T155	R:R:Y151	2.5	Yes	Yes	3	7	5
86	R:R:W194	R:R:Y151	2.89	No	Yes	3	9	5
87	R:R:S197	R:R:Y151	2.54	No	Yes	3	8	5
88	R:R:S198	R:R:Y151	5.09	No	Yes	0	4	5
89	R:R:G201	R:R:Y151	7.24	No	Yes	0	6	5
90	R:R:N152	R:R:S156	2.98	No	No	0	8	9
91	R:R:N152	R:R:W295	3.39	No	Yes	0	8	8
92	R:R:M153	R:R:W295	3.49	No	Yes	0	7	8
93	R:R:F154	R:R:F158	3.22	Yes	No	0	6	5
94	R:R:F154	R:R:S197	3.96	Yes	No	0	6	8
95	R:R:F154	R:R:I200	21.35	Yes	No	0	6	5
96	R:R:F154	R:R:V238	3.93	Yes	No	0	6	5
97	R:R:A242	R:R:F154	4.16	No	Yes	0	5	6
98	R:R:T155	R:R:W194	6.06	Yes	No	3	7	9
99	R:R:S197	R:R:T155	4.8	No	Yes	3	8	7
100	R:R:F291	R:R:S156	3.96	Yes	No	0	9	9
101	R:R:I157	R:R:P246	6.77	No	No	0	7	8
102	R:R:F291	R:R:I157	3.77	Yes	No	0	9	7
103	R:R:F158	R:R:N193	6.04	No	No	0	5	7
104	R:R:T159	R:R:T162	3.14	Yes	No	0	8	7
105	R:R:N193	R:R:T159	4.39	No	Yes	0	7	8
106	R:R:L160	R:R:V288	2.98	No	No	0	8	8
107	R:R:F291	R:R:L160	6.09	Yes	No	0	9	8
108	R:R:C161	R:R:I249	4.91	No	No	0	7	6
109	R:R:I189	R:R:T162	3.04	No	No	1	5	7
110	R:R:M163	R:R:V284	3.04	No	No	0	9	8
111	R:R:I250	R:R:S164	4.64	No	No	0	8	9
112	R:R:C253	R:R:S164	3.44	Yes	No	0	8	9
113	R:R:S164	R:R:Y254	3.82	No	Yes	0	9	9
114	R:R:D166	R:R:R167	4.76	No	Yes	1	8	9
115	R:R:D166	R:R:R181	13.1	No	Yes	1	8	7
116	R:R:R167	R:R:R181	3.2	Yes	Yes	1	9	7
117	R:R:I280	R:R:R167	7.52	No	Yes	0	8	9
118	R:R:R167	R:R:T281	3.88	Yes	No	0	9	6
119	R:R:R167	R:R:V284	6.54	Yes	No	0	9	8
120	R:R:C172	R:R:Y168	9.41	No	Yes	7	7	8
121	R:R:H173	R:R:Y168	4.36	No	Yes	7	6	8
122	R:R:C253	R:R:Y168	2.69	Yes	Yes	0	8	8
123	R:R:L256	R:R:Y168	4.69	No	Yes	0	5	8
124	R:R:M257	R:R:Y168	2.39	No	Yes	0	8	8
125	R:R:A177	R:R:I169	3.25	No	No	1	6	5
126	R:R:F180	R:R:I169	3.77	No	No	1	3	5
127	R:R:I169	R:R:R181	2.51	No	Yes	1	5	7
128	R:R:A170	R:R:R181	6.91	No	Yes	0	8	7
129	R:R:M257	R:R:V171	9.13	No	No	0	8	8
130	R:R:R260	R:R:V171	2.62	No	No	0	5	8
131	R:R:L261	R:R:V171	2.98	No	No	0	8	8
132	R:R:C172	R:R:H173	4.42	No	No	7	7	6
133	R:R:C172	R:R:R260	5.57	No	No	0	7	5
134	R:R:D179	R:R:K176	4.15	No	No	1	5	4
135	R:R:F180	R:R:K176	12.41	No	No	1	3	4
136	R:R:A177	R:R:R181	2.77	No	Yes	1	6	7
137	R:R:D179	R:R:F180	7.17	No	No	1	5	3
138	R:R:P183	R:R:T182	5.25	No	No	0	1	7
139	R:R:R184	R:R:T182	9.06	No	No	8	3	7
140	R:R:N185	R:R:T182	2.92	No	No	8	4	7
141	R:R:N185	R:R:R184	15.67	No	No	8	4	3
142	R:R:I188	R:R:I189	2.94	No	No	0	3	5
143	R:R:L202	R:R:S198	4.5	No	No	0	4	4
144	R:R:L202	R:R:M205	4.24	No	No	0	4	5
145	R:R:M207	R:R:T222	3.01	No	No	0	5	4
146	R:R:I217	R:R:T210	3.04	No	Yes	0	4	4
147	R:R:G215	R:R:Y212	2.9	No	No	0	5	3
148	R:R:I217	R:R:Y212	2.42	No	No	0	4	3
149	R:R:D218	R:R:R213	25.01	No	No	0	4	2
150	R:R:D218	R:R:T220	7.23	No	No	0	4	4
151	R:R:F223	R:R:T227	5.19	Yes	No	9	6	3
152	R:R:F223	R:R:W230	11.02	Yes	No	0	6	1
153	R:R:E231	R:R:F223	12.83	No	Yes	9	4	6
154	R:R:S224	R:R:W230	2.47	No	No	0	3	1
155	R:R:E231	R:R:T227	11.29	No	No	9	4	3
156	R:R:W230	R:R:Y229	2.89	No	No	0	1	1
157	R:R:I236	R:R:L233	2.85	No	No	0	4	3
158	R:R:C237	R:R:L233	3.17	No	No	0	5	3
159	R:R:K235	R:R:V302	3.04	No	No	0	4	5
160	R:R:A306	R:R:K235	4.82	No	No	0	4	4
161	R:R:F239	R:R:I240	3.77	No	No	0	6	5
162	R:R:F239	R:R:I244	5.02	No	No	0	6	4
163	R:R:F239	R:R:I303	8.79	No	No	0	6	5
164	R:R:F241	R:R:I240	3.77	No	No	0	4	5
165	R:R:F243	R:R:I244	3.77	No	No	0	8	4
166	R:R:F243	R:R:V247	5.24	No	No	0	8	6
167	R:R:F243	R:R:T296	2.59	No	No	0	8	5
168	R:R:I244	R:R:M245	2.92	No	No	0	4	5
169	R:R:M245	R:R:P246	3.35	No	No	0	5	8
170	R:R:I250	R:R:V288	4.61	No	No	0	8	8
171	R:R:T281	R:R:Y254	3.75	No	Yes	0	6	9
172	R:R:V284	R:R:Y254	3.79	No	Yes	0	8	9
173	R:R:L285	R:R:Y254	10.55	No	Yes	0	5	9
174	R:R:R260	R:R:V264	2.62	No	No	0	5	6
175	R:R:L261	R:R:R278	2.43	No	No	0	8	5
176	R:R:L267	R:R:V264	2.98	No	No	0	1	6
177	R:R:D274	R:R:L266	2.71	No	No	0	1	4
178	R:R:D274	R:R:L267	2.71	No	No	0	1	1
179	R:R:L267	R:R:L277	2.77	No	No	0	1	6
180	R:R:K273	R:R:S268	9.18	No	No	0	3	4
181	R:R:K273	R:R:N276	2.8	No	No	0	3	5
182	R:R:K273	R:R:L277	8.46	No	No	0	3	6
183	R:R:D274	R:R:R278	17.87	No	No	0	1	5
184	R:R:R279	R:R:R282	4.26	No	No	0	7	5
185	R:R:M283	R:R:Y338	4.79	No	Yes	0	8	9
186	R:R:L341	R:R:M283	5.65	No	No	0	7	8
187	R:R:L341	R:R:V286	4.47	No	No	0	7	6
188	R:R:V287	R:R:Y338	3.79	No	Yes	0	8	9
189	R:R:F291	R:R:W295	13.03	Yes	Yes	6	9	8
190	R:R:F291	R:R:N330	7.25	Yes	No	6	9	9
191	R:R:C294	R:R:N330	9.45	No	No	0	9	9
192	R:R:I298	R:R:W295	2.35	No	Yes	0	6	8
193	R:R:N330	R:R:W295	6.78	No	Yes	6	9	8
194	R:R:P297	R:R:T296	3.5	No	No	0	9	5
195	R:R:H299	R:R:I298	2.65	No	No	0	7	6
196	R:R:I298	R:R:W320	2.35	No	Yes	0	6	4
197	R:R:S319	R:R:Y301	5.09	No	No	0	4	5
198	R:R:C323	R:R:Y301	6.72	No	No	0	6	5
199	R:R:V302	R:R:W320	2.45	No	Yes	0	5	4
200	R:R:I303	R:R:L307	2.85	No	No	0	5	5
201	R:R:K305	R:R:Q316	2.71	No	Yes	0	3	3
202	R:R:K305	R:R:W320	10.44	No	Yes	0	3	4
203	R:R:I310	R:R:P311	5.08	No	No	0	4	1
204	R:R:I310	R:R:Q316	2.74	No	Yes	0	4	3
205	R:R:E312	R:R:Q316	3.82	No	Yes	0	2	3
206	R:R:Q316	R:R:T313	5.67	Yes	No	0	3	3
207	R:R:Q316	R:R:T317	5.67	Yes	No	0	3	4
208	R:R:H321	R:R:T317	2.74	No	No	0	4	4
209	R:R:H321	R:R:W320	6.35	No	Yes	0	4	4
210	R:R:I324	R:R:W320	7.05	No	Yes	0	5	4
211	R:R:F322	R:R:L326	3.65	No	No	0	4	8
212	R:R:L333	R:R:L337	2.77	No	No	0	6	8
213	R:R:N334	R:R:Y338	4.65	No	Yes	0	9	9
214	R:R:A339	R:R:F340	4.16	No	No	0	6	6
215	R:R:A339	R:R:F349	2.77	No	Yes	0	6	6
216	R:R:F340	R:R:K346	2.48	No	No	0	6	8
217	R:R:D342	R:R:N344	5.39	No	No	0	8	7
218	R:R:D342	R:R:F345	14.33	No	Yes	0	8	8
219	R:R:E343	R:R:N344	7.89	No	No	0	5	7
220	R:R:E343	R:R:R347	3.49	No	No	0	5	5
221	R:R:F345	R:R:F349	4.29	Yes	Yes	0	8	6
222	R:R:C348	R:R:E351	3.04	No	No	0	6	3
223	R:R:C353	R:R:R350	5.57	No	No	0	5	5
224	R:R:L123	R:R:Y77	2.34	No	No	0	7	7
225	R:R:C332	R:R:G84	1.96	No	No	0	8	8
226	R:R:C81	R:R:P124	1.88	No	No	0	6	8
227	R:R:C323	R:R:P297	1.88	No	No	0	6	9
228	R:R:G133	R:R:T134	1.82	No	No	0	2	5
229	R:R:P124	R:R:S127	1.78	No	No	0	8	6
230	R:R:P335	R:R:V91	1.77	No	No	0	9	9
231	R:R:G133	R:R:M132	1.75	No	No	0	2	4
232	R:R:C253	R:R:V165	1.71	Yes	No	0	8	6
233	R:R:C294	R:R:V290	1.71	No	No	0	9	7
234	R:R:G84	R:R:N88	1.7	No	Yes	0	8	9
235	R:R:M207	R:R:P203	1.68	No	No	0	5	8
236	R:R:C219	R:R:I146	1.64	No	No	0	9	4
237	R:R:C192	R:R:I188	1.64	No	No	0	2	3
238	R:R:L202	R:R:P203	1.64	No	No	0	4	8
239	R:R:C253	R:R:I249	1.64	Yes	No	0	8	6
240	R:R:S121	R:R:T122	1.6	No	Yes	0	5	6
241	R:R:C81	R:R:L85	1.59	No	No	0	6	6
242	R:R:T251	R:R:V247	1.59	No	No	0	5	6
243	R:R:C294	R:R:L333	1.59	No	No	0	9	6
244	R:R:T314	R:R:V318	1.59	No	No	0	1	1
245	R:R:A208	R:R:L221	1.58	No	No	0	5	4
246	R:R:A113	R:R:N88	1.56	No	Yes	0	9	9
247	R:R:A306	R:R:N232	1.56	No	No	0	4	2
248	R:R:I144	R:R:V145	1.54	No	No	0	5	5
249	R:R:I146	R:R:V204	1.54	No	No	0	4	5
250	R:R:I188	R:R:V191	1.54	No	No	0	3	4
251	R:R:I292	R:R:V247	1.54	No	No	0	6	6
252	R:R:I292	R:R:V288	1.54	No	No	0	6	8
253	R:R:I304	R:R:V308	1.54	No	No	0	5	2
254	R:R:H173	R:R:P174	1.53	No	No	0	6	8
255	R:R:F86	R:R:G87	1.51	No	No	0	5	8
256	R:R:L248	R:R:V252	1.49	No	No	0	3	4
257	R:R:L307	R:R:V308	1.49	No	No	0	5	2
258	R:R:L326	R:R:T329	1.47	No	No	0	8	5
259	R:R:E272	R:R:S270	1.44	No	No	0	3	2
260	R:R:A186	R:R:Y108	1.33	No	Yes	0	7	7
261	R:R:F315	R:R:V318	1.31	No	No	0	2	1
262	R:R:F315	R:R:T313	1.3	No	No	0	2	3
263	R:R:F206	R:R:M207	1.24	No	No	0	4	5
264	R:R:K211	R:R:R213	1.24	No	No	0	1	2
265	R:R:F223	R:R:L221	1.22	Yes	No	0	6	4
266	R:R:L76	R:R:Y77	1.17	No	No	0	5	7
267	R:R:L131	R:R:Y130	1.17	No	No	0	4	5
268	R:R:N232	R:R:W228	1.13	No	No	0	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N88	3.432	5	0	9
2	R:R:M101	4.365	4	0	7
3	R:R:Y108	4.798	5	1	7
4	R:R:T122	6.0025	4	5	6
5	R:R:W135	4.838	5	2	8
6	R:R:F137	6.865	4	2	6
7	R:R:Y151	3.8	6	3	5
8	R:R:F154	7.324	5	0	6
9	R:R:T155	4.18	4	3	7
10	R:R:T159	5.18	4	0	8
11	R:R:R167	6.04167	6	1	9
12	R:R:Y168	4.708	5	7	8
13	R:R:R181	5.21	6	1	7
14	R:R:T210	4.96	4	2	4
15	R:R:F223	7.565	4	9	6
16	R:R:C253	2.37	4	0	8
17	R:R:Y254	5.4775	4	0	9
18	R:R:F291	6.82	5	6	9
19	R:R:W295	5.808	5	6	8
20	R:R:Q316	4.122	5	0	3
21	R:R:W320	5.728	5	0	4
22	R:R:Y338	5.725	4	0	9
23	R:R:F345	5.9375	4	0	8
24	R:R:F349	3.6375	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C81	R:R:L123	21.8326	6.35	No	No	0	6	7
2	R:R:C81	R:R:L85	26.0992	1.59	No	No	0	6	6
3	R:R:L85	R:R:T120	27.554	7.37	No	No	0	6	5
4	R:R:S331	R:R:T120	28.9979	3.2	No	No	0	9	5
5	R:R:D116	R:R:S331	30.431	5.89	No	No	0	9	9
6	R:R:D116	R:R:N88	53.2515	2.69	No	Yes	0	9	9
7	R:R:G84	R:R:N88	11.242	1.7	No	Yes	0	8	9
8	R:R:N88	R:R:P335	40.2779	6.52	Yes	No	0	9	9
9	R:R:P335	R:R:V91	33.384	1.77	No	No	0	9	9
10	R:R:F349	R:R:V91	31.9672	2.62	Yes	No	0	6	9
11	R:R:F345	R:R:F349	24.9213	4.29	Yes	Yes	0	8	6
12	R:R:F345	R:R:V94	12.8053	2.62	Yes	No	0	8	7
13	R:R:M101	R:R:V94	11.242	3.04	Yes	No	0	7	7
14	R:R:D116	R:R:N334	76.6963	5.39	No	No	0	9	9
15	R:R:N334	R:R:Y338	77.706	4.65	No	Yes	0	9	9
16	R:R:I109	R:R:Y338	82.3418	9.67	No	Yes	0	8	9
17	R:R:I109	R:R:M163	83.2971	2.92	No	No	0	8	9
18	R:R:M163	R:R:Y108	65.0581	5.99	No	Yes	0	9	7
19	R:R:T162	R:R:Y108	71.6915	4.99	No	Yes	1	7	7
20	R:R:T159	R:R:T162	76.4195	3.14	Yes	No	0	8	7
21	R:R:N111	R:R:T159	77.1415	8.77	No	Yes	0	9	8
22	R:R:N111	R:R:N190	13.4133	14.98	No	No	0	9	7
23	R:R:I107	R:R:N190	11.774	4.25	No	No	0	5	7
24	R:R:D166	R:R:R181	10.0803	13.1	No	Yes	1	8	7
25	R:R:D166	R:R:Y108	14.3741	8.05	No	Yes	1	8	7
26	R:R:M163	R:R:V284	23.3905	3.04	No	No	0	9	8
27	R:R:N111	R:R:W194	67.6637	9.04	No	No	0	9	9
28	R:R:L112	R:R:T159	100	4.42	No	Yes	0	9	8
29	R:R:L112	R:R:S156	52.8987	3	No	No	0	9	9
30	R:R:L112	R:R:L160	48.4204	5.54	No	No	0	9	8
31	R:R:L123	R:R:Y328	15.7746	5.86	No	No	0	7	7
32	R:R:Q126	R:R:Y328	12.6696	5.64	No	No	0	6	7
33	R:R:N152	R:R:S156	22.4188	2.98	No	No	0	8	9
34	R:R:W194	R:R:Y151	62.2028	2.89	No	Yes	3	9	5
35	R:R:S147	R:R:Y151	51.6339	2.54	No	Yes	0	6	5
36	R:R:M205	R:R:S147	50.3963	6.13	No	No	0	5	6
37	R:R:K143	R:R:M205	50.2063	10.08	No	No	0	6	5
38	R:R:A208	R:R:K143	48.8926	3.21	No	No	0	5	6
39	R:R:A208	R:R:I146	38.1283	3.25	No	No	0	5	4
40	R:R:C219	R:R:I146	32.5535	1.64	No	No	0	9	4
41	R:R:C142	R:R:C219	31.1964	7.28	No	No	0	9	9
42	R:R:C142	R:R:W135	10.8403	6.53	No	Yes	2	9	8
43	R:R:C142	R:R:T210	18.885	3.38	No	Yes	2	9	4
44	R:R:I217	R:R:T210	14.651	3.04	No	Yes	0	4	4
45	R:R:N152	R:R:W295	20.6167	3.39	No	Yes	0	8	8
46	R:R:I298	R:R:W295	62.5719	2.35	No	Yes	0	6	8
47	R:R:I298	R:R:W320	56.9971	2.35	No	Yes	0	6	4
48	R:R:H321	R:R:W320	11.508	6.35	No	Yes	0	4	4
49	R:R:F291	R:R:S156	31.2941	3.96	Yes	No	0	9	9
50	R:R:F291	R:R:W295	48.1272	13.03	Yes	Yes	6	9	8
51	R:R:F291	R:R:L160	39.442	6.09	Yes	No	0	9	8
52	R:R:F291	R:R:I157	15.2915	3.77	Yes	No	0	9	7
53	R:R:I157	R:R:P246	13.3265	6.77	No	No	0	7	8
54	R:R:V284	R:R:Y254	22.3103	3.79	No	Yes	0	8	9
55	R:R:S164	R:R:Y254	25.1276	3.82	No	Yes	0	9	9
56	R:R:I250	R:R:S164	28.9708	4.64	No	No	0	8	9
57	R:R:I250	R:R:V288	29.0142	4.61	No	No	0	8	8
58	R:R:C253	R:R:S164	29.8502	3.44	Yes	No	0	8	9
59	R:R:C253	R:R:Y168	25.2687	2.69	Yes	Yes	0	8	8
60	R:R:C172	R:R:Y168	12.7402	9.41	No	Yes	7	7	8
61	R:R:C172	R:R:R260	11.6437	5.57	No	No	0	7	5
62	R:R:A208	R:R:L221	11.3017	1.58	No	No	0	5	4
63	R:R:V302	R:R:W320	14.6292	2.45	No	Yes	0	5	4
64	R:R:K235	R:R:V302	11.6817	3.04	No	No	0	4	5
65	R:R:I292	R:R:V288	20.1335	1.54	No	No	0	6	8
66	R:R:I292	R:R:V247	18.9447	1.54	No	No	0	6	6
67	R:R:F243	R:R:V247	16.5563	5.24	No	No	0	8	6
68	R:R:F243	R:R:I244	10.3029	3.77	No	No	0	8	4
69	R:R:F239	R:R:I244	14.841	5.02	No	No	0	6	4
70	R:R:M245	R:R:P246	11.3668	3.35	No	No	0	5	8
71	R:R:R260	R:R:V264	10.406	2.62	No	No	0	5	6
72	R:R:F291	R:R:N330	10.0369	7.25	Yes	No	6	9	9
73	R:R:K305	R:R:W320	26.1752	10.44	No	Yes	0	3	4
74	R:R:K305	R:R:Q316	23.5262	2.71	No	Yes	0	3	3
75	R:R:Q316	R:R:T313	11.9368	5.67	Yes	No	0	3	3
76	R:R:L160	R:R:V288	26.6746	2.98	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9MQH

PDB Summary
PDB	9MQH
Class	A
SubFamily	Peptide
Type	Opioid
SubType	MOP
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.9
Date	2025-02-12
D.O.I.	doi.org/10.1101/2025.01.09.632033

Net Summary
I_min	2.35
Number of Linked Nodes	251
Number of Links	268
Number of Hubs	24
Number of Links mediated by Hubs	104
Number of Communities	9
Number of Nodes involved in Communities	38
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	39034
Length Of Smallest Path	3
Average Path Length	15.6925
Length of Longest Path	35
Minimum Path Strength	1.305
Average Path Strength	4.87595
Maximum Path Strength	16.12
Minimum Path Correlation	0.7
Average Path Correlation	0.926224
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.795
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	26.9577
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • protein binding • binding • G-protein beta-subunit binding • neuropeptide binding • peptide binding • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • metabolic process • regulation of nitric oxide metabolic process • regulation of metabolic process • multicellular organismal process • system process • sensory perception • nervous system process • behavior • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • synapse • cell junction • axon • endoplasmic reticulum
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>9MQH_Chain_R T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R L S G S E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F C I L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9MQH.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.