psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A68	R:R:Y128	4	No	No	0	4	5
2	R:R:I71	R:R:Y75	3.63	Yes	Yes	3	4	7
3	R:R:I71	R:R:Y128	7.25	Yes	No	3	4	5
4	R:R:H319	R:R:I71	11.93	No	Yes	3	4	4
5	R:R:M72	R:R:S125	4.6	Yes	No	0	5	6
6	R:R:L129	R:R:M72	11.31	No	Yes	0	5	5
7	R:R:L121	R:R:Y75	7.03	Yes	Yes	0	7	7
8	R:R:S125	R:R:Y75	5.09	No	Yes	0	6	7
9	R:R:H319	R:R:Y75	15.24	No	Yes	3	4	7
10	R:R:I322	R:R:Y75	7.25	Yes	Yes	0	5	7
11	R:R:C79	R:R:L121	4.76	Yes	Yes	0	6	7
12	R:R:C79	R:R:P122	7.53	Yes	No	0	6	8
13	R:R:G82	R:R:V81	3.68	No	No	0	8	5
14	R:R:G82	R:R:T118	3.64	No	No	0	8	6
15	R:R:C330	R:R:G82	3.92	No	No	0	7	8
16	R:R:D114	R:R:N86	6.73	Yes	No	0	9	9
17	R:R:A115	R:R:N86	4.69	No	No	0	7	9
18	R:R:N86	R:R:P333	8.15	No	No	0	9	9
19	R:R:F338	R:R:L88	3.65	No	No	0	6	6
20	R:R:P333	R:R:V89	3.53	No	Yes	0	9	9
21	R:R:A337	R:R:V89	5.09	No	Yes	0	7	9
22	R:R:F338	R:R:V89	3.93	No	Yes	0	6	9
23	R:R:F108	R:R:M90	7.46	No	No	0	6	7
24	R:R:L112	R:R:M90	4.24	No	No	0	6	7
25	R:R:R95	R:R:Y91	17.49	No	No	0	4	4
26	R:R:F343	R:R:V92	3.93	Yes	No	0	9	7
27	R:R:F347	R:R:V92	3.93	No	No	0	6	7
28	R:R:F108	R:R:I93	6.28	No	No	0	6	7
29	R:R:F343	R:R:I93	5.02	Yes	No	0	9	7
30	R:R:R95	R:R:V94	6.54	No	No	0	4	3
31	R:R:N104	R:R:T97	10.24	No	No	0	8	6
32	R:R:K100	R:R:K98	7.18	No	No	0	6	5
33	R:R:I105	R:R:M99	4.37	Yes	No	0	6	7
34	R:R:F108	R:R:M99	8.71	No	No	0	6	7
35	R:R:N104	R:R:T101	4.39	No	No	0	8	8
36	R:R:F343	R:R:N104	4.83	Yes	No	0	9	8
37	R:R:I105	R:R:N109	4.25	Yes	No	0	6	9
38	R:R:T160	R:R:Y106	4.99	No	Yes	0	7	7
39	R:R:M161	R:R:Y106	4.79	No	Yes	0	8	7
40	R:R:D164	R:R:Y106	5.75	No	Yes	0	8	7
41	R:R:A184	R:R:Y106	5.34	No	Yes	0	7	7
42	R:R:D340	R:R:I107	4.2	No	No	0	8	8
43	R:R:N109	R:R:N188	19.07	No	No	0	9	7
44	R:R:D114	R:R:L110	4.07	Yes	Yes	2	9	9
45	R:R:L110	R:R:T157	7.37	Yes	No	0	9	7
46	R:R:L110	R:R:L158	5.54	Yes	No	2	9	8
47	R:R:L110	R:R:N332	8.24	Yes	Yes	2	9	9
48	R:R:D114	R:R:S154	5.89	Yes	No	0	9	9
49	R:R:D114	R:R:S329	11.78	Yes	No	0	9	9
50	R:R:D114	R:R:N332	8.08	Yes	Yes	2	9	9
51	R:R:L116	R:R:N150	10.98	No	No	0	7	8
52	R:R:A117	R:R:N150	4.69	No	No	0	7	8
53	R:R:Q124	R:R:T120	4.25	Yes	Yes	1	6	6
54	R:R:D147	R:R:T120	8.67	Yes	Yes	1	6	6
55	R:R:L121	R:R:Y326	7.03	Yes	Yes	0	7	7
56	R:R:F123	R:R:W133	5.01	No	Yes	1	6	8
57	R:R:F123	R:R:F135	7.5	No	Yes	1	6	7
58	R:R:F123	R:R:V143	5.24	No	No	1	6	5
59	R:R:D147	R:R:Q124	5.22	Yes	Yes	1	6	6
60	R:R:Q124	R:R:Y326	4.51	Yes	Yes	1	6	7
61	L:L:?1	R:R:Q124	14.71	Yes	Yes	1	0	6
62	R:R:N127	R:R:W133	7.91	No	Yes	0	6	8
63	R:R:H319	R:R:Y128	11.98	No	No	3	4	5
64	R:R:I215	R:R:T132	7.6	No	No	0	4	5
65	R:R:P134	R:R:W133	5.4	No	Yes	1	4	8
66	R:R:F135	R:R:W133	11.02	Yes	Yes	1	7	8
67	R:R:C140	R:R:W133	5.22	No	Yes	1	9	8
68	R:R:V143	R:R:W133	6.13	No	Yes	1	5	8
69	R:R:C217	R:R:W133	6.53	No	Yes	1	9	8
70	L:L:?1	R:R:W133	4.2	Yes	Yes	1	0	8
71	R:R:F135	R:R:P134	11.56	Yes	No	1	7	4
72	R:R:F135	R:R:L139	6.09	Yes	No	0	7	6
73	R:R:K141	R:R:N137	9.79	No	No	0	6	1
74	R:R:N137	R:R:T208	4.39	No	Yes	0	1	5
75	R:R:C140	R:R:T208	5.07	No	Yes	1	9	5
76	R:R:C140	R:R:C217	5.46	No	No	1	9	9
77	R:R:I144	R:R:L219	5.71	No	No	0	5	5
78	L:L:?1	R:R:I144	6.31	Yes	No	0	0	5
79	R:R:S145	R:R:V202	4.85	No	No	0	6	5
80	R:R:I146	R:R:N150	4.25	No	No	0	5	8
81	R:R:D147	R:R:Y326	8.05	Yes	Yes	1	6	7
82	L:L:?1	R:R:D147	13	Yes	Yes	1	0	6
83	R:R:L219	R:R:Y148	4.69	No	No	0	5	4
84	L:L:?1	R:R:Y148	6.05	Yes	No	0	0	4
85	R:R:T153	R:R:Y149	3.75	Yes	Yes	4	7	4
86	R:R:W192	R:R:Y149	11.58	No	Yes	4	9	4
87	R:R:S195	R:R:Y149	3.82	No	Yes	4	8	4
88	R:R:S196	R:R:Y149	3.82	No	Yes	0	3	4
89	R:R:F152	R:R:M151	3.73	Yes	No	0	7	7
90	R:R:M151	R:R:W293	4.65	No	Yes	1	7	8
91	L:L:?1	R:R:M151	4.17	Yes	No	1	0	7
92	R:R:F152	R:R:F156	8.57	Yes	No	0	7	6
93	R:R:F152	R:R:I198	13.82	Yes	No	0	7	4
94	R:R:T153	R:R:W192	13.34	Yes	No	4	7	9
95	R:R:S195	R:R:T153	4.8	No	Yes	4	8	7
96	R:R:I155	R:R:W293	5.87	No	Yes	0	8	8
97	R:R:F156	R:R:N191	4.83	No	No	0	6	7
98	R:R:L158	R:R:N332	8.24	No	Yes	2	8	9
99	R:R:L158	R:R:Y336	4.69	No	Yes	2	8	9
100	R:R:C159	R:R:P244	3.77	No	No	0	7	9
101	R:R:N191	R:R:T160	7.31	No	No	0	7	7
102	R:R:M161	R:R:Y336	8.38	No	Yes	0	8	9
103	R:R:I248	R:R:S162	6.19	No	No	0	8	9
104	R:R:C251	R:R:S162	5.16	No	No	0	7	9
105	R:R:S162	R:R:Y252	5.09	No	Yes	0	9	9
106	R:R:D164	R:R:R179	14.29	No	No	0	8	6
107	R:R:R165	R:R:Y252	6.17	No	Yes	2	9	9
108	R:R:R165	R:R:Y336	6.17	No	Yes	2	9	9
109	R:R:C170	R:R:Y166	9.41	No	Yes	6	7	8
110	R:R:H171	R:R:Y166	8.71	Yes	Yes	6	6	8
111	R:R:C251	R:R:Y166	6.72	No	Yes	0	7	8
112	R:R:L254	R:R:Y166	7.03	No	Yes	0	4	8
113	R:R:A168	R:R:R179	5.53	No	No	0	8	6
114	R:R:M255	R:R:V169	6.09	No	No	0	8	8
115	R:R:C170	R:R:H171	5.9	No	Yes	6	7	6
116	R:R:N183	R:R:T180	7.31	No	No	0	4	7
117	R:R:N188	R:R:W192	9.04	No	No	0	7	9
118	R:R:F204	R:R:L200	13.4	No	No	0	5	3
119	R:R:K209	R:R:T207	10.51	No	No	0	3	5
120	R:R:C217	R:R:T208	5.07	No	Yes	1	9	5
121	R:R:K209	R:R:T218	4.5	No	No	0	3	3
122	R:R:I215	R:R:Y210	9.67	No	No	0	4	1
123	R:R:R211	R:R:S214	3.95	No	No	0	3	2
124	R:R:D216	R:R:R211	19.06	No	No	0	4	3
125	R:R:T220	R:R:T225	4.71	No	No	0	4	3
126	R:R:E229	R:R:T220	7.06	No	No	0	4	4
127	R:R:S222	R:R:W228	13.59	No	Yes	0	6	3
128	R:R:P224	R:R:W226	4.05	Yes	No	5	1	2
129	R:R:P224	R:R:Y227	4.17	Yes	Yes	5	1	3
130	R:R:P224	R:R:W228	8.11	Yes	Yes	5	1	3
131	R:R:W226	R:R:Y227	3.86	No	Yes	5	2	3
132	R:R:W228	R:R:Y227	11.58	Yes	Yes	5	3	3
133	R:R:E229	R:R:K233	5.4	No	No	0	4	4
134	R:R:F237	R:R:I238	3.77	Yes	No	0	5	4
135	R:R:F237	R:R:I242	6.28	Yes	No	0	5	5
136	R:R:F237	R:R:H297	4.53	Yes	Yes	0	5	8
137	R:R:F237	R:R:I301	6.28	Yes	No	0	5	6
138	R:R:F239	R:R:I238	3.77	No	No	0	4	4
139	R:R:F241	R:R:V245	3.93	No	No	0	8	6
140	R:R:F241	R:R:T294	10.38	No	No	0	8	5
141	R:R:F241	R:R:H297	11.31	No	Yes	0	8	8
142	R:R:I290	R:R:V245	4.61	No	No	0	5	6
143	R:R:F289	R:R:I248	5.02	No	No	0	9	8
144	R:R:M255	R:R:Y252	3.59	No	Yes	0	8	9
145	R:R:V282	R:R:Y252	10.09	No	Yes	0	7	9
146	R:R:V286	R:R:Y252	5.05	No	Yes	0	8	9
147	R:R:Y252	R:R:Y336	4.96	Yes	Yes	2	9	9
148	R:R:L259	R:R:M255	4.24	No	No	0	8	8
149	R:R:I256	R:R:T279	9.12	No	No	0	5	6
150	R:R:I256	R:R:V282	4.61	No	No	0	5	7
151	R:R:R258	R:R:V262	3.92	No	No	0	5	6
152	R:R:L265	R:R:L275	6.92	No	No	0	3	6
153	R:R:K271	R:R:S268	4.59	No	No	0	4	4
154	R:R:K269	R:R:R273	6.19	No	No	0	1	4
155	R:R:E270	R:R:R273	6.98	No	No	0	2	4
156	R:R:N274	R:R:R277	8.44	No	No	0	5	7
157	R:R:R276	R:R:R280	6.4	No	No	0	5	6
158	R:R:I278	R:R:R277	5.01	No	No	0	7	7
159	R:R:E341	R:R:R277	5.82	No	No	0	4	7
160	R:R:L339	R:R:M281	8.48	No	No	0	6	8
161	R:R:L335	R:R:V285	5.96	No	No	0	8	8
162	R:R:V285	R:R:Y336	7.57	No	Yes	0	8	9
163	R:R:L335	R:R:V288	4.47	No	No	0	8	6
164	R:R:F289	R:R:W293	12.03	No	Yes	0	9	8
165	R:R:C292	R:R:N328	7.87	No	No	0	8	9
166	R:R:H297	R:R:W293	6.35	Yes	Yes	1	8	8
167	R:R:N328	R:R:W293	7.91	No	Yes	0	9	8
168	L:L:?1	R:R:W293	11.75	Yes	Yes	1	0	8
169	R:R:H297	R:R:I296	3.98	Yes	No	0	8	6
170	R:R:I296	R:R:I322	4.42	No	Yes	0	6	5
171	L:L:?1	R:R:H297	4.74	Yes	Yes	1	0	8
172	R:R:Q314	R:R:Y299	5.64	Yes	Yes	0	4	4
173	R:R:S317	R:R:Y299	6.36	No	Yes	0	5	4
174	R:R:W318	R:R:Y299	5.79	No	Yes	0	5	4
175	R:R:C321	R:R:Y299	4.03	No	Yes	0	6	4
176	R:R:K303	R:R:Q314	4.07	No	Yes	0	4	4
177	R:R:K303	R:R:W318	10.44	No	No	0	4	5
178	R:R:I308	R:R:Q314	13.72	No	Yes	0	1	4
179	R:R:E310	R:R:Q314	16.57	No	Yes	0	1	4
180	R:R:E310	R:R:T315	5.64	No	No	0	1	4
181	R:R:F313	R:R:S317	3.96	No	No	0	2	5
182	R:R:I322	R:R:W318	5.87	Yes	No	0	5	5
183	L:L:?1	R:R:I322	4.21	Yes	Yes	0	0	5
184	L:L:?1	R:R:Y326	18.14	Yes	Yes	1	0	7
185	R:R:N328	R:R:N332	8.17	No	Yes	0	9	9
186	L:L:?1	R:R:S329	6.64	Yes	No	0	0	9
187	R:R:F338	R:R:V334	3.93	No	No	0	6	6
188	R:R:A337	R:R:F343	4.16	No	Yes	0	7	9
189	R:R:D340	R:R:N342	8.08	No	No	0	8	6
190	R:R:D340	R:R:F343	7.17	No	Yes	0	8	9
191	R:R:E341	R:R:K344	9.45	No	No	0	4	8
192	R:R:N342	R:R:R345	3.62	No	No	0	6	4
193	R:R:F347	R:R:R348	4.28	No	No	0	6	5
194	R:R:L231	R:R:Y227	3.52	No	Yes	0	4	3
195	R:R:P181	R:R:T180	3.5	No	No	0	1	7
196	R:R:P295	R:R:T294	3.5	No	No	0	9	5
197	R:R:C251	R:R:V163	3.42	No	No	0	7	6
198	R:R:A111	R:R:V89	3.39	No	Yes	0	9	9
199	R:R:I155	R:R:P244	3.39	No	No	0	8	9
200	R:R:C79	R:R:T118	3.38	Yes	No	0	6	6
201	R:R:C292	R:R:T327	3.38	No	No	0	8	5
202	R:R:A113	R:R:T153	3.36	No	Yes	0	8	7
203	L:L:?1	R:R:V300	3.29	Yes	No	0	0	5
204	R:R:L200	R:R:P201	3.28	No	No	0	3	7
205	R:R:L324	R:R:P295	3.28	No	No	0	7	9
206	R:R:C159	R:R:I247	3.27	No	No	0	7	7
207	R:R:A68	R:R:M65	3.22	No	No	0	4	2
208	R:R:A304	R:R:K233	3.21	No	No	0	4	4
209	R:R:C79	R:R:L83	3.17	Yes	No	0	6	6
210	R:R:T160	R:R:V187	3.17	No	No	0	7	5
211	R:R:A323	R:R:L74	3.15	No	No	0	4	5
212	R:R:M72	R:R:S76	3.07	Yes	No	0	5	4
213	R:R:I144	R:R:V202	3.07	No	No	0	5	5
214	R:R:M203	R:R:S145	3.07	No	No	0	4	6
215	R:R:I167	R:R:V163	3.07	No	No	0	5	6
216	R:R:H223	R:R:P224	3.05	No	Yes	0	4	1
217	R:R:I107	R:R:T103	3.04	No	No	0	8	8
218	R:R:I146	R:R:T120	3.04	No	Yes	0	5	6
219	R:R:K233	R:R:V300	3.04	No	No	0	4	5
220	R:R:F84	R:R:G85	3.01	No	No	0	4	7
221	R:R:K141	R:R:T207	3	No	No	0	6	5
222	R:R:L121	R:R:V78	2.98	Yes	No	0	7	7
223	R:R:L335	R:R:V284	2.98	No	No	0	8	6
224	R:R:L331	R:R:T327	2.95	No	No	0	7	5
225	R:R:I298	R:R:I302	2.94	No	No	0	6	5
226	R:R:I302	R:R:I306	2.94	No	No	0	5	3
227	R:R:I105	R:R:K185	2.91	Yes	No	0	6	2
228	R:R:I256	R:R:K260	2.91	No	No	0	5	4
229	R:R:D216	R:R:T218	2.89	No	No	0	4	3
230	R:R:I242	R:R:L246	2.85	No	No	0	5	3
231	R:R:I301	R:R:L305	2.85	No	No	0	6	5
232	R:R:K260	R:R:L257	2.82	No	No	0	4	2
233	R:R:K344	R:R:L339	2.82	No	No	0	8	6
234	R:R:C170	R:R:R258	2.79	No	No	0	7	5
235	R:R:A175	R:R:R179	2.77	No	No	0	6	6
236	R:R:L259	R:R:L265	2.77	No	No	0	8	3
237	R:R:A102	R:R:Y106	2.67	No	Yes	0	6	7
238	R:R:F135	R:R:V126	2.62	Yes	No	0	7	5
239	R:R:F152	R:R:V236	2.62	Yes	No	0	7	5
240	R:R:I186	R:R:R182	2.51	No	No	0	3	3
241	R:R:F87	R:R:M90	2.49	No	No	0	4	7
242	R:R:F84	R:R:L88	2.44	No	No	0	4	6
243	R:R:F156	R:R:L194	2.44	No	No	0	6	4
244	R:R:D177	R:R:F178	2.39	No	No	0	4	4
245	R:R:E341	R:R:R345	2.33	No	No	0	4	4
246	R:R:R273	R:R:R276	2.13	No	No	0	4	5
247	R:R:R95	R:R:Y96	2.06	No	No	0	4	5
248	R:R:G199	R:R:S145	1.86	No	No	0	7	6
249	R:R:A73	R:R:S76	1.71	No	No	0	5	4
250	R:R:G325	R:R:L324	1.71	No	No	0	7	7
251	R:R:A206	R:R:V202	1.7	No	No	0	4	5
252	R:R:A240	R:R:V236	1.7	No	No	0	6	5
253	R:R:I105	R:R:P181	1.69	Yes	No	0	6	1
254	R:R:I308	R:R:P309	1.69	No	No	0	1	3
255	R:R:M205	R:R:P201	1.68	No	No	0	4	7
256	R:R:M243	R:R:P244	1.68	No	No	0	5	9
257	R:R:G213	R:R:Q212	1.64	No	No	0	3	5
258	R:R:S119	R:R:T120	1.6	No	Yes	0	5	6
259	R:R:T70	R:R:V66	1.59	No	No	0	4	2
260	R:R:T249	R:R:V245	1.59	No	No	0	4	6
261	R:R:T249	R:R:V286	1.59	No	No	0	4	8
262	R:R:T312	R:R:V316	1.59	No	No	0	4	1
263	R:R:T67	R:R:T70	1.57	No	No	0	3	4
264	R:R:T311	R:R:T312	1.57	No	No	0	1	4
265	R:R:I71	R:R:V316	1.54	Yes	No	0	4	1
266	R:R:I77	R:R:V78	1.54	No	No	0	5	7
267	R:R:I77	R:R:V81	1.54	No	No	0	5	5
268	R:R:I142	R:R:V143	1.54	No	No	0	5	5
269	R:R:I193	R:R:V189	1.54	No	No	0	4	4
270	R:R:H171	R:R:P172	1.53	Yes	No	0	6	7
271	R:R:K269	R:R:S268	1.53	No	No	0	1	4
272	R:R:I71	R:R:T70	1.52	Yes	No	0	4	4
273	R:R:M130	R:R:V126	1.52	No	No	0	3	5
274	R:R:K174	R:R:V173	1.52	No	No	0	4	5
275	R:R:I215	R:R:T208	1.52	No	Yes	0	4	5
276	R:R:M264	R:R:V262	1.52	No	No	0	5	6
277	R:R:I298	R:R:T294	1.52	No	No	0	6	5
278	R:R:L254	R:R:V250	1.49	No	No	0	4	4
279	R:R:I234	R:R:I238	1.47	No	No	0	4	4
280	R:R:I69	R:R:M72	1.46	No	Yes	0	4	5
281	R:R:I77	R:R:L74	1.43	No	No	0	5	5
282	R:R:I198	R:R:L232	1.43	No	No	0	4	5
283	R:R:L200	R:R:M203	1.41	No	No	0	3	4
284	R:R:D272	R:R:L275	1.36	No	No	0	3	6
285	R:R:F221	R:R:S222	1.32	No	No	0	5	6
286	R:R:R258	R:R:S261	1.32	No	No	0	5	4
287	R:R:H171	R:R:K174	1.31	Yes	No	0	6	4
288	R:R:E270	R:R:N274	1.31	No	No	0	2	5
289	R:R:R280	R:R:V284	1.31	No	No	0	6	6
290	R:R:R182	R:R:T180	1.29	No	No	0	3	7
291	R:R:F178	R:R:I167	1.26	No	No	0	4	5
292	R:R:M205	R:R:W228	1.16	No	Yes	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I71	5.174	5	3	4
2	R:R:M72	5.11	4	0	5
3	R:R:Y75	7.648	5	3	7
4	R:R:C79	4.71	4	0	6
5	R:R:V89	3.985	4	0	9
6	R:R:I105	3.305	4	0	6
7	R:R:Y106	4.708	5	0	7
8	R:R:L110	6.305	4	2	9
9	R:R:D114	7.31	5	2	9
10	R:R:T120	4.39	4	1	6
11	R:R:L121	5.45	4	0	7
12	R:R:Q124	7.1725	4	1	6
13	R:R:W133	6.4275	8	1	8
14	R:R:F135	7.758	5	1	7
15	R:R:D147	8.735	4	1	6
16	R:R:Y149	5.7425	4	4	4
17	R:R:F152	7.185	4	0	7
18	R:R:T153	6.3125	4	4	7
19	R:R:Y166	7.9675	4	6	8
20	R:R:H171	4.3625	4	6	6
21	R:R:T208	4.0125	4	1	5
22	R:R:P224	4.845	4	5	1
23	R:R:Y227	5.7825	4	5	3
24	R:R:W228	8.61	4	5	3
25	R:R:F237	5.215	4	0	5
26	R:R:Y252	5.825	6	2	9
27	R:R:W293	8.09333	6	1	8
28	R:R:H297	6.182	5	1	8
29	R:R:Y299	5.455	4	0	4
30	R:R:Q314	10	4	0	4
31	R:R:I322	5.4375	4	0	5
32	R:R:Y326	9.4325	4	1	7
33	R:R:N332	8.1825	4	2	9
34	R:R:Y336	6.354	5	2	9
35	R:R:F343	5.022	5	0	9
36	L:L:?1	8.10083	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I71	R:R:Y75	23.8742	3.63	Yes	Yes	3	4	7
2	R:R:S125	R:R:Y75	14.8894	5.09	No	Yes	0	6	7
3	R:R:M72	R:R:S125	12.4422	4.6	Yes	No	0	5	6
4	R:R:I322	R:R:Y75	46.6173	7.25	Yes	Yes	0	5	7
5	R:R:C79	R:R:L121	13.2745	4.76	Yes	Yes	0	6	7
6	R:R:L121	R:R:V78	11.0763	2.98	Yes	No	0	7	7
7	L:L:?1	R:R:I322	72.3839	4.21	Yes	Yes	0	0	5
8	L:L:?1	R:R:S329	97.9868	6.64	Yes	No	0	0	9
9	R:R:D114	R:R:S329	97.5528	11.78	Yes	No	0	9	9
10	R:R:D114	R:R:N86	100	6.73	Yes	No	0	9	9
11	R:R:N86	R:R:P333	96.4715	8.15	No	No	0	9	9
12	R:R:P333	R:R:V89	94.7286	3.53	No	Yes	0	9	9
13	R:R:F338	R:R:V89	12.1576	3.93	No	Yes	0	6	9
14	R:R:A337	R:R:V89	82.5781	5.09	No	Yes	0	7	9
15	R:R:A337	R:R:F343	80.8067	4.16	No	Yes	0	7	9
16	R:R:F343	R:R:I93	50.5158	5.02	Yes	No	0	9	7
17	R:R:F108	R:R:I93	48.3958	6.28	No	No	0	6	7
18	R:R:F108	R:R:M99	39.66	8.71	No	No	0	6	7
19	R:R:I105	R:R:M99	37.4404	4.37	Yes	No	0	6	7
20	R:R:I105	R:R:N109	21.5053	4.25	Yes	No	0	6	9
21	L:L:?1	R:R:M151	22.238	4.17	Yes	No	1	0	7
22	R:R:F152	R:R:M151	26.0582	3.73	Yes	No	0	7	7
23	R:R:F152	R:R:F156	16.7532	8.57	Yes	No	0	7	6
24	R:R:F156	R:R:N191	13.5377	4.83	No	No	0	6	7
25	R:R:N191	R:R:T160	12.2999	7.31	No	No	0	7	7
26	R:R:T160	R:R:Y106	11.9869	4.99	No	Yes	0	7	7
27	L:L:?1	R:R:W293	57.7292	11.75	Yes	Yes	1	0	8
28	R:R:N328	R:R:W293	28.0928	7.91	No	Yes	0	9	8
29	R:R:N328	R:R:N332	25.4749	8.17	No	Yes	0	9	9
30	R:R:L158	R:R:N332	51.2271	8.24	No	Yes	2	8	9
31	R:R:L158	R:R:Y336	80.3728	4.69	No	Yes	2	8	9
32	R:R:M161	R:R:Y336	16.8101	8.38	No	Yes	0	8	9
33	R:R:D114	R:R:N332	37.4049	8.08	Yes	Yes	2	9	9
34	R:R:D114	R:R:L110	34.6304	4.07	Yes	Yes	2	9	9
35	R:R:L110	R:R:L158	32.4963	5.54	Yes	No	2	9	8
36	R:R:D164	R:R:Y106	10.1515	5.75	No	Yes	0	8	7
37	R:R:D340	R:R:F343	23.8244	7.17	No	Yes	0	8	9
38	R:R:N109	R:R:N188	19.1719	19.07	No	No	0	9	7
39	R:R:L121	R:R:Y326	25.1974	7.03	Yes	Yes	0	7	7
40	R:R:Q124	R:R:T120	13.8579	4.25	Yes	Yes	1	6	6
41	R:R:I146	R:R:T120	18.7736	3.04	No	Yes	0	5	6
42	R:R:I146	R:R:N150	14.0997	4.25	No	No	0	5	8
43	L:L:?1	R:R:Q124	14.2278	14.71	Yes	Yes	1	0	6
44	R:R:D147	R:R:T120	14.0357	8.67	Yes	Yes	1	6	6
45	L:L:?1	R:R:D147	14.6333	13	Yes	Yes	1	0	6
46	L:L:?1	R:R:W133	71.7863	4.2	Yes	Yes	1	0	8
47	R:R:C140	R:R:W133	27.1039	5.22	No	Yes	1	9	8
48	R:R:C140	R:R:T208	25.0907	5.07	No	Yes	1	9	5
49	R:R:I215	R:R:T208	12.8192	1.52	No	Yes	0	4	5
50	R:R:C217	R:R:W133	26.9332	6.53	No	Yes	1	9	8
51	R:R:C217	R:R:T208	25.0907	5.07	No	Yes	1	9	5
52	R:R:N137	R:R:T208	33.5705	4.39	No	Yes	0	1	5
53	R:R:K141	R:R:N137	29.3804	9.79	No	No	0	6	1
54	L:L:?1	R:R:I144	42.036	6.31	Yes	No	0	0	5
55	R:R:I144	R:R:V202	38.5715	3.07	No	No	0	5	5
56	R:R:S145	R:R:V202	34.4882	4.85	No	No	0	6	5
57	R:R:N188	R:R:W192	16.8244	9.04	No	No	0	7	9
58	R:R:I155	R:R:W293	12.2288	5.87	No	Yes	0	8	8
59	R:R:F289	R:R:W293	38.7209	12.03	No	Yes	0	9	8
60	R:R:F289	R:R:I248	37.1416	5.02	No	No	0	9	8
61	R:R:I248	R:R:S162	35.7117	6.19	No	No	0	8	9
62	R:R:C251	R:R:S162	38.977	5.16	No	No	0	7	9
63	R:R:S162	R:R:Y252	33.9333	5.09	No	Yes	0	9	9
64	R:R:C251	R:R:Y166	27.8793	6.72	No	Yes	0	7	8
65	R:R:C170	R:R:Y166	11.6028	9.41	No	Yes	6	7	8
66	R:R:M255	R:R:Y252	14.1922	3.59	No	Yes	0	8	9
67	R:R:I105	R:R:P181	12.0865	1.69	Yes	No	0	6	1
68	R:R:M203	R:R:S145	30.3479	3.07	No	No	0	4	6
69	R:R:L200	R:R:M203	28.2564	1.41	No	No	0	3	4
70	R:R:K141	R:R:T207	25.1761	3	No	No	0	6	5
71	R:R:K209	R:R:T207	20.9575	10.51	No	No	0	3	5
72	R:R:K209	R:R:T218	16.7248	4.5	No	No	0	3	3
73	R:R:D216	R:R:T218	12.4778	2.89	No	No	0	4	3
74	L:L:?1	R:R:V300	13.0398	3.29	Yes	No	0	0	5
75	R:R:K233	R:R:V300	11.0123	3.04	No	No	0	4	5
76	R:R:L200	R:R:P201	24.0307	3.28	No	No	0	3	7
77	R:R:M205	R:R:P201	21.8966	1.68	No	No	0	4	7
78	R:R:M205	R:R:W228	19.7482	1.16	No	Yes	0	4	3
79	R:R:F237	R:R:H297	20.2533	4.53	Yes	Yes	0	5	8
80	L:L:?1	R:R:H297	30.3052	4.74	Yes	Yes	1	0	8
81	R:R:F241	R:R:H297	24.3935	11.31	No	Yes	0	8	8
82	R:R:F241	R:R:V245	11.1902	3.93	No	No	0	8	6
83	R:R:F241	R:R:T294	17.3721	10.38	No	No	0	8	5
84	R:R:V282	R:R:Y252	11.8162	10.09	No	Yes	0	7	9
85	R:R:V285	R:R:Y336	47.3999	7.57	No	Yes	0	8	9
86	R:R:L335	R:R:V285	43.4801	5.96	No	No	0	8	8
87	R:R:L335	R:R:V284	35.541	2.98	No	No	0	8	6
88	R:R:R280	R:R:V284	31.8062	1.31	No	No	0	6	6
89	R:R:R276	R:R:R280	28.4769	6.4	No	No	0	5	6
90	R:R:R273	R:R:R276	25.1974	2.13	No	No	0	4	5
91	R:R:K269	R:R:R273	11.8162	6.19	No	No	0	1	4
92	R:R:E270	R:R:R273	12.3639	6.98	No	No	0	2	4
93	R:R:D340	R:R:N342	17.3294	8.08	No	No	0	8	6
94	R:R:N342	R:R:R345	15.1739	3.62	No	No	0	6	4
95	R:R:E341	R:R:R345	13.3314	2.33	No	No	0	4	4
96	R:R:I322	R:R:W318	36.4516	5.87	Yes	No	0	5	5
97	R:R:W318	R:R:Y299	20.5236	5.79	No	Yes	0	5	4
98	R:R:Q314	R:R:Y299	11.5316	5.64	Yes	Yes	0	4	4
99	R:R:K303	R:R:W318	13.7298	10.44	No	No	0	4	5
100	R:R:K303	R:R:Q314	11.6312	4.07	No	Yes	0	4	4
101	L:L:?1	R:R:Y326	23.6181	18.14	Yes	Yes	1	0	7
102	R:R:M161	R:R:Y106	12.8833	4.79	No	Yes	0	8	7
103	R:R:Y252	R:R:Y336	32.1335	4.96	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L121	R:R:Y75	7.03	0	Yes	Yes	7	7	2	2
R:R:I322	R:R:Y75	7.25	0	Yes	Yes	5	7	1	2
R:R:D114	R:R:S329	11.78	2	Yes	No	9	9	2	1
R:R:Q124	R:R:T120	4.25	1	Yes	Yes	6	6	1	2
R:R:D147	R:R:T120	8.67	1	Yes	Yes	6	6	1	2
R:R:L121	R:R:Y326	7.03	0	Yes	Yes	7	7	2	1
R:R:F123	R:R:W133	5.01	1	No	Yes	6	8	2	1
R:R:F123	R:R:F135	7.5	1	No	Yes	6	7	2	2
R:R:F123	R:R:V143	5.24	1	No	No	6	5	2	2
R:R:D147	R:R:Q124	5.22	1	Yes	Yes	6	6	1	1
R:R:Q124	R:R:Y326	4.51	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:Q124	14.71	1	Yes	Yes	0	6	0	1
R:R:N127	R:R:W133	7.91	0	No	Yes	6	8	2	1
R:R:P134	R:R:W133	5.4	1	No	Yes	4	8	2	1
R:R:F135	R:R:W133	11.02	1	Yes	Yes	7	8	2	1
R:R:C140	R:R:W133	5.22	1	No	Yes	9	8	2	1
R:R:V143	R:R:W133	6.13	1	No	Yes	5	8	2	1
R:R:C217	R:R:W133	6.53	1	No	Yes	9	8	2	1
L:L:?1	R:R:W133	4.2	1	Yes	Yes	0	8	0	1
R:R:F135	R:R:P134	11.56	1	Yes	No	7	4	2	2
R:R:C140	R:R:C217	5.46	1	No	No	9	9	2	2
R:R:I144	R:R:L219	5.71	0	No	No	5	5	1	2
L:L:?1	R:R:I144	6.31	1	Yes	No	0	5	0	1
R:R:D147	R:R:Y326	8.05	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:D147	13	1	Yes	Yes	0	6	0	1
R:R:L219	R:R:Y148	4.69	0	No	No	5	4	2	1
L:L:?1	R:R:Y148	6.05	1	Yes	No	0	4	0	1
R:R:F152	R:R:M151	3.73	0	Yes	No	7	7	2	1
R:R:M151	R:R:W293	4.65	1	No	Yes	7	8	1	1
L:L:?1	R:R:M151	4.17	1	Yes	No	0	7	0	1
R:R:I155	R:R:W293	5.87	0	No	Yes	8	8	2	1
R:R:F237	R:R:H297	4.53	0	Yes	Yes	5	8	2	1
R:R:F241	R:R:H297	11.31	0	No	Yes	8	8	2	1
R:R:F289	R:R:W293	12.03	0	No	Yes	9	8	2	1
R:R:H297	R:R:W293	6.35	1	Yes	Yes	8	8	1	1
R:R:N328	R:R:W293	7.91	0	No	Yes	9	8	2	1
L:L:?1	R:R:W293	11.75	1	Yes	Yes	0	8	0	1
R:R:H297	R:R:I296	3.98	1	Yes	No	8	6	1	2
R:R:I296	R:R:I322	4.42	0	No	Yes	6	5	2	1
L:L:?1	R:R:H297	4.74	1	Yes	Yes	0	8	0	1
R:R:I322	R:R:W318	5.87	0	Yes	No	5	5	1	2
L:L:?1	R:R:I322	4.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y326	18.14	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S329	6.64	1	Yes	No	0	9	0	1
L:L:?1	R:R:V300	3.29	1	Yes	No	0	5	0	1
R:R:I144	R:R:V202	3.07	0	No	No	5	5	1	2
R:R:K233	R:R:V300	3.04	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7U2L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	266
Number of Links	292
Number of Hubs	36
Number of Links mediated by Hubs	138
Number of Communities	6
Number of Nodes involved in Communities	38
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	48940
Length Of Smallest Path	3
Average Path Length	12.1518
Length of Longest Path	28
Minimum Path Strength	1.415
Average Path Strength	5.99371
Maximum Path Strength	15.145
Minimum Path Correlation	0.7
Average Path Correlation	0.926905
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	52.6283
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.2458
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled opioid receptor activity • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • behavior • locomotory behavior • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • metabolic process • regulation of nitric oxide metabolic process • regulation of metabolic process • transmission of nerve impulse • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • neurogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • dendrite • dendritic tree • GABA-ergic synapse • endosome • intracellular vesicle • cytoplasmic vesicle • axon • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	L0X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	L0X
Name	N-(5-carbamimidamidopentyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Synonyms
Identifier
Formula	C22 H37 N5 O
Molecular Weight	387.562
SMILES
PubChem	163201242
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	0
Total Bonds	66
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>7U2L_nogp_Chain_R M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

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