psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A68	R:R:Y128	4	No	No	0	4	5
2	R:R:I71	R:R:Y75	3.63	Yes	Yes	3	4	7
3	R:R:I71	R:R:Y128	7.25	Yes	No	3	4	5
4	R:R:H319	R:R:I71	11.93	No	Yes	3	4	4
5	R:R:M72	R:R:S125	4.6	Yes	No	0	5	6
6	R:R:L129	R:R:M72	11.31	No	Yes	0	5	5
7	R:R:L121	R:R:Y75	7.03	Yes	Yes	0	7	7
8	R:R:S125	R:R:Y75	5.09	No	Yes	0	6	7
9	R:R:H319	R:R:Y75	15.24	No	Yes	3	4	7
10	R:R:I322	R:R:Y75	7.25	Yes	Yes	0	5	7
11	R:R:C79	R:R:L121	4.76	Yes	Yes	0	6	7
12	R:R:C79	R:R:P122	7.53	Yes	No	0	6	8
13	R:R:G82	R:R:V81	3.68	No	No	0	8	5
14	R:R:G82	R:R:T118	3.64	No	No	0	8	6
15	R:R:C330	R:R:G82	3.92	No	No	0	7	8
16	R:R:D114	R:R:N86	6.73	Yes	No	0	9	9
17	R:R:A115	R:R:N86	4.69	No	No	0	7	9
18	R:R:N86	R:R:P333	8.15	No	No	0	9	9
19	R:R:F338	R:R:L88	3.65	No	No	0	6	6
20	R:R:P333	R:R:V89	3.53	No	Yes	0	9	9
21	R:R:A337	R:R:V89	5.09	No	Yes	0	7	9
22	R:R:F338	R:R:V89	3.93	No	Yes	0	6	9
23	R:R:F108	R:R:M90	7.46	No	No	0	6	7
24	R:R:L112	R:R:M90	4.24	No	No	0	6	7
25	R:R:R95	R:R:Y91	17.49	No	No	0	4	4
26	R:R:F343	R:R:V92	3.93	Yes	No	0	9	7
27	R:R:F347	R:R:V92	3.93	No	No	0	6	7
28	R:R:F108	R:R:I93	6.28	No	No	0	6	7
29	R:R:F343	R:R:I93	5.02	Yes	No	0	9	7
30	R:R:R95	R:R:V94	6.54	No	No	0	4	3
31	R:R:N104	R:R:T97	10.24	No	No	0	8	6
32	R:R:K100	R:R:K98	7.18	No	No	0	6	5
33	R:R:I105	R:R:M99	4.37	Yes	No	0	6	7
34	R:R:F108	R:R:M99	8.71	No	No	0	6	7
35	R:R:N104	R:R:T101	4.39	No	No	0	8	8
36	R:R:F343	R:R:N104	4.83	Yes	No	0	9	8
37	R:R:I105	R:R:N109	4.25	Yes	No	0	6	9
38	R:R:T160	R:R:Y106	4.99	No	Yes	0	7	7
39	R:R:M161	R:R:Y106	4.79	No	Yes	0	8	7
40	R:R:D164	R:R:Y106	5.75	No	Yes	0	8	7
41	R:R:A184	R:R:Y106	5.34	No	Yes	0	7	7
42	R:R:D340	R:R:I107	4.2	No	No	0	8	8
43	R:R:N109	R:R:N188	19.07	No	No	0	9	7
44	R:R:D114	R:R:L110	4.07	Yes	Yes	2	9	9
45	R:R:L110	R:R:T157	7.37	Yes	No	0	9	7
46	R:R:L110	R:R:L158	5.54	Yes	No	2	9	8
47	R:R:L110	R:R:N332	8.24	Yes	Yes	2	9	9
48	R:R:D114	R:R:S154	5.89	Yes	No	0	9	9
49	R:R:D114	R:R:S329	11.78	Yes	No	0	9	9
50	R:R:D114	R:R:N332	8.08	Yes	Yes	2	9	9
51	R:R:L116	R:R:N150	10.98	No	No	0	7	8
52	R:R:A117	R:R:N150	4.69	No	No	0	7	8
53	R:R:Q124	R:R:T120	4.25	Yes	Yes	1	6	6
54	R:R:D147	R:R:T120	8.67	Yes	Yes	1	6	6
55	R:R:L121	R:R:Y326	7.03	Yes	Yes	0	7	7
56	R:R:F123	R:R:W133	5.01	No	Yes	1	6	8
57	R:R:F123	R:R:F135	7.5	No	Yes	1	6	7
58	R:R:F123	R:R:V143	5.24	No	No	1	6	5
59	R:R:D147	R:R:Q124	5.22	Yes	Yes	1	6	6
60	R:R:Q124	R:R:Y326	4.51	Yes	Yes	1	6	7
61	L:L:?1	R:R:Q124	14.71	Yes	Yes	1	0	6
62	R:R:N127	R:R:W133	7.91	No	Yes	0	6	8
63	R:R:H319	R:R:Y128	11.98	No	No	3	4	5
64	R:R:I215	R:R:T132	7.6	No	No	0	4	5
65	R:R:P134	R:R:W133	5.4	No	Yes	1	4	8
66	R:R:F135	R:R:W133	11.02	Yes	Yes	1	7	8
67	R:R:C140	R:R:W133	5.22	No	Yes	1	9	8
68	R:R:V143	R:R:W133	6.13	No	Yes	1	5	8
69	R:R:C217	R:R:W133	6.53	No	Yes	1	9	8
70	L:L:?1	R:R:W133	4.2	Yes	Yes	1	0	8
71	R:R:F135	R:R:P134	11.56	Yes	No	1	7	4
72	R:R:F135	R:R:L139	6.09	Yes	No	0	7	6
73	R:R:K141	R:R:N137	9.79	No	No	0	6	1
74	R:R:N137	R:R:T208	4.39	No	Yes	0	1	5
75	R:R:C140	R:R:T208	5.07	No	Yes	1	9	5
76	R:R:C140	R:R:C217	5.46	No	No	1	9	9
77	R:R:I144	R:R:L219	5.71	No	No	0	5	5
78	L:L:?1	R:R:I144	6.31	Yes	No	0	0	5
79	R:R:S145	R:R:V202	4.85	No	No	0	6	5
80	R:R:I146	R:R:N150	4.25	No	No	0	5	8
81	R:R:D147	R:R:Y326	8.05	Yes	Yes	1	6	7
82	L:L:?1	R:R:D147	13	Yes	Yes	1	0	6
83	R:R:L219	R:R:Y148	4.69	No	No	0	5	4
84	L:L:?1	R:R:Y148	6.05	Yes	No	0	0	4
85	R:R:T153	R:R:Y149	3.75	Yes	Yes	4	7	4
86	R:R:W192	R:R:Y149	11.58	No	Yes	4	9	4
87	R:R:S195	R:R:Y149	3.82	No	Yes	4	8	4
88	R:R:S196	R:R:Y149	3.82	No	Yes	0	3	4
89	R:R:F152	R:R:M151	3.73	Yes	No	0	7	7
90	R:R:M151	R:R:W293	4.65	No	Yes	1	7	8
91	L:L:?1	R:R:M151	4.17	Yes	No	1	0	7
92	R:R:F152	R:R:F156	8.57	Yes	No	0	7	6
93	R:R:F152	R:R:I198	13.82	Yes	No	0	7	4
94	R:R:T153	R:R:W192	13.34	Yes	No	4	7	9
95	R:R:S195	R:R:T153	4.8	No	Yes	4	8	7
96	R:R:I155	R:R:W293	5.87	No	Yes	0	8	8
97	R:R:F156	R:R:N191	4.83	No	No	0	6	7
98	R:R:L158	R:R:N332	8.24	No	Yes	2	8	9
99	R:R:L158	R:R:Y336	4.69	No	Yes	2	8	9
100	R:R:C159	R:R:P244	3.77	No	No	0	7	9
101	R:R:N191	R:R:T160	7.31	No	No	0	7	7
102	R:R:M161	R:R:Y336	8.38	No	Yes	0	8	9
103	R:R:I248	R:R:S162	6.19	No	No	0	8	9
104	R:R:C251	R:R:S162	5.16	No	No	0	7	9
105	R:R:S162	R:R:Y252	5.09	No	Yes	0	9	9
106	R:R:D164	R:R:R179	14.29	No	No	0	8	6
107	R:R:R165	R:R:Y252	6.17	No	Yes	2	9	9
108	R:R:R165	R:R:Y336	6.17	No	Yes	2	9	9
109	R:R:C170	R:R:Y166	9.41	No	Yes	6	7	8
110	R:R:H171	R:R:Y166	8.71	Yes	Yes	6	6	8
111	R:R:C251	R:R:Y166	6.72	No	Yes	0	7	8
112	R:R:L254	R:R:Y166	7.03	No	Yes	0	4	8
113	R:R:A168	R:R:R179	5.53	No	No	0	8	6
114	R:R:M255	R:R:V169	6.09	No	No	0	8	8
115	R:R:C170	R:R:H171	5.9	No	Yes	6	7	6
116	R:R:N183	R:R:T180	7.31	No	No	0	4	7
117	R:R:N188	R:R:W192	9.04	No	No	0	7	9
118	R:R:F204	R:R:L200	13.4	No	No	0	5	3
119	R:R:K209	R:R:T207	10.51	No	No	0	3	5
120	R:R:C217	R:R:T208	5.07	No	Yes	1	9	5
121	R:R:K209	R:R:T218	4.5	No	No	0	3	3
122	R:R:I215	R:R:Y210	9.67	No	No	0	4	1
123	R:R:R211	R:R:S214	3.95	No	No	0	3	2
124	R:R:D216	R:R:R211	19.06	No	No	0	4	3
125	R:R:T220	R:R:T225	4.71	No	No	0	4	3
126	R:R:E229	R:R:T220	7.06	No	No	0	4	4
127	R:R:S222	R:R:W228	13.59	No	Yes	0	6	3
128	R:R:P224	R:R:W226	4.05	Yes	No	5	1	2
129	R:R:P224	R:R:Y227	4.17	Yes	Yes	5	1	3
130	R:R:P224	R:R:W228	8.11	Yes	Yes	5	1	3
131	R:R:W226	R:R:Y227	3.86	No	Yes	5	2	3
132	R:R:W228	R:R:Y227	11.58	Yes	Yes	5	3	3
133	R:R:E229	R:R:K233	5.4	No	No	0	4	4
134	R:R:F237	R:R:I238	3.77	Yes	No	0	5	4
135	R:R:F237	R:R:I242	6.28	Yes	No	0	5	5
136	R:R:F237	R:R:H297	4.53	Yes	Yes	0	5	8
137	R:R:F237	R:R:I301	6.28	Yes	No	0	5	6
138	R:R:F239	R:R:I238	3.77	No	No	0	4	4
139	R:R:F241	R:R:V245	3.93	No	No	0	8	6
140	R:R:F241	R:R:T294	10.38	No	No	0	8	5
141	R:R:F241	R:R:H297	11.31	No	Yes	0	8	8
142	R:R:I290	R:R:V245	4.61	No	No	0	5	6
143	R:R:F289	R:R:I248	5.02	No	No	0	9	8
144	R:R:M255	R:R:Y252	3.59	No	Yes	0	8	9
145	R:R:V282	R:R:Y252	10.09	No	Yes	0	7	9
146	R:R:V286	R:R:Y252	5.05	No	Yes	0	8	9
147	R:R:Y252	R:R:Y336	4.96	Yes	Yes	2	9	9
148	R:R:L259	R:R:M255	4.24	No	No	0	8	8
149	R:R:I256	R:R:T279	9.12	No	No	0	5	6
150	R:R:I256	R:R:V282	4.61	No	No	0	5	7
151	R:R:R258	R:R:V262	3.92	No	No	0	5	6
152	R:R:L265	R:R:L275	6.92	No	No	0	3	6
153	R:R:K271	R:R:S268	4.59	No	No	0	4	4
154	R:R:K269	R:R:R273	6.19	No	No	0	1	4
155	R:R:E270	R:R:R273	6.98	No	No	0	2	4
156	R:R:N274	R:R:R277	8.44	No	No	0	5	7
157	R:R:R276	R:R:R280	6.4	No	No	0	5	6
158	R:R:I278	R:R:R277	5.01	No	No	0	7	7
159	R:R:E341	R:R:R277	5.82	No	No	0	4	7
160	R:R:L339	R:R:M281	8.48	No	No	0	6	8
161	R:R:L335	R:R:V285	5.96	No	No	0	8	8
162	R:R:V285	R:R:Y336	7.57	No	Yes	0	8	9
163	R:R:L335	R:R:V288	4.47	No	No	0	8	6
164	R:R:F289	R:R:W293	12.03	No	Yes	0	9	8
165	R:R:C292	R:R:N328	7.87	No	No	0	8	9
166	R:R:H297	R:R:W293	6.35	Yes	Yes	1	8	8
167	R:R:N328	R:R:W293	7.91	No	Yes	0	9	8
168	L:L:?1	R:R:W293	11.75	Yes	Yes	1	0	8
169	R:R:H297	R:R:I296	3.98	Yes	No	0	8	6
170	R:R:I296	R:R:I322	4.42	No	Yes	0	6	5
171	L:L:?1	R:R:H297	4.74	Yes	Yes	1	0	8
172	R:R:Q314	R:R:Y299	5.64	Yes	Yes	0	4	4
173	R:R:S317	R:R:Y299	6.36	No	Yes	0	5	4
174	R:R:W318	R:R:Y299	5.79	No	Yes	0	5	4
175	R:R:C321	R:R:Y299	4.03	No	Yes	0	6	4
176	R:R:K303	R:R:Q314	4.07	No	Yes	0	4	4
177	R:R:K303	R:R:W318	10.44	No	No	0	4	5
178	R:R:I308	R:R:Q314	13.72	No	Yes	0	1	4
179	R:R:E310	R:R:Q314	16.57	No	Yes	0	1	4
180	R:R:E310	R:R:T315	5.64	No	No	0	1	4
181	R:R:F313	R:R:S317	3.96	No	No	0	2	5
182	R:R:I322	R:R:W318	5.87	Yes	No	0	5	5
183	L:L:?1	R:R:I322	4.21	Yes	Yes	0	0	5
184	L:L:?1	R:R:Y326	18.14	Yes	Yes	1	0	7
185	R:R:N328	R:R:N332	8.17	No	Yes	0	9	9
186	L:L:?1	R:R:S329	6.64	Yes	No	0	0	9
187	R:R:F338	R:R:V334	3.93	No	No	0	6	6
188	R:R:A337	R:R:F343	4.16	No	Yes	0	7	9
189	R:R:D340	R:R:N342	8.08	No	No	0	8	6
190	R:R:D340	R:R:F343	7.17	No	Yes	0	8	9
191	R:R:E341	R:R:K344	9.45	No	No	0	4	8
192	R:R:N342	R:R:R345	3.62	No	No	0	6	4
193	R:R:F347	R:R:R348	4.28	No	No	0	6	5
194	R:R:L231	R:R:Y227	3.52	No	Yes	0	4	3
195	R:R:P181	R:R:T180	3.5	No	No	0	1	7
196	R:R:P295	R:R:T294	3.5	No	No	0	9	5
197	R:R:C251	R:R:V163	3.42	No	No	0	7	6
198	R:R:A111	R:R:V89	3.39	No	Yes	0	9	9
199	R:R:I155	R:R:P244	3.39	No	No	0	8	9
200	R:R:C79	R:R:T118	3.38	Yes	No	0	6	6
201	R:R:C292	R:R:T327	3.38	No	No	0	8	5
202	R:R:A113	R:R:T153	3.36	No	Yes	0	8	7
203	L:L:?1	R:R:V300	3.29	Yes	No	0	0	5
204	R:R:L200	R:R:P201	3.28	No	No	0	3	7
205	R:R:L324	R:R:P295	3.28	No	No	0	7	9
206	R:R:C159	R:R:I247	3.27	No	No	0	7	7
207	R:R:A68	R:R:M65	3.22	No	No	0	4	2
208	R:R:A304	R:R:K233	3.21	No	No	0	4	4
209	R:R:C79	R:R:L83	3.17	Yes	No	0	6	6
210	R:R:T160	R:R:V187	3.17	No	No	0	7	5
211	R:R:A323	R:R:L74	3.15	No	No	0	4	5
212	R:R:M72	R:R:S76	3.07	Yes	No	0	5	4
213	R:R:I144	R:R:V202	3.07	No	No	0	5	5
214	R:R:M203	R:R:S145	3.07	No	No	0	4	6
215	R:R:I167	R:R:V163	3.07	No	No	0	5	6
216	R:R:H223	R:R:P224	3.05	No	Yes	0	4	1
217	R:R:I107	R:R:T103	3.04	No	No	0	8	8
218	R:R:I146	R:R:T120	3.04	No	Yes	0	5	6
219	R:R:K233	R:R:V300	3.04	No	No	0	4	5
220	R:R:F84	R:R:G85	3.01	No	No	0	4	7
221	R:R:K141	R:R:T207	3	No	No	0	6	5
222	R:R:L121	R:R:V78	2.98	Yes	No	0	7	7
223	R:R:L335	R:R:V284	2.98	No	No	0	8	6
224	R:R:L331	R:R:T327	2.95	No	No	0	7	5
225	R:R:I298	R:R:I302	2.94	No	No	0	6	5
226	R:R:I302	R:R:I306	2.94	No	No	0	5	3
227	R:R:I105	R:R:K185	2.91	Yes	No	0	6	2
228	R:R:I256	R:R:K260	2.91	No	No	0	5	4
229	R:R:D216	R:R:T218	2.89	No	No	0	4	3
230	R:R:I242	R:R:L246	2.85	No	No	0	5	3
231	R:R:I301	R:R:L305	2.85	No	No	0	6	5
232	R:R:K260	R:R:L257	2.82	No	No	0	4	2
233	R:R:K344	R:R:L339	2.82	No	No	0	8	6
234	R:R:C170	R:R:R258	2.79	No	No	0	7	5
235	R:R:A175	R:R:R179	2.77	No	No	0	6	6
236	R:R:L259	R:R:L265	2.77	No	No	0	8	3
237	R:R:A102	R:R:Y106	2.67	No	Yes	0	6	7
238	R:R:F135	R:R:V126	2.62	Yes	No	0	7	5
239	R:R:F152	R:R:V236	2.62	Yes	No	0	7	5
240	R:R:I186	R:R:R182	2.51	No	No	0	3	3
241	R:R:F87	R:R:M90	2.49	No	No	0	4	7
242	R:R:F84	R:R:L88	2.44	No	No	0	4	6
243	R:R:F156	R:R:L194	2.44	No	No	0	6	4
244	R:R:D177	R:R:F178	2.39	No	No	0	4	4
245	R:R:E341	R:R:R345	2.33	No	No	0	4	4
246	R:R:R273	R:R:R276	2.13	No	No	0	4	5
247	R:R:R95	R:R:Y96	2.06	No	No	0	4	5
248	R:R:G199	R:R:S145	1.86	No	No	0	7	6
249	R:R:A73	R:R:S76	1.71	No	No	0	5	4
250	R:R:G325	R:R:L324	1.71	No	No	0	7	7
251	R:R:A206	R:R:V202	1.7	No	No	0	4	5
252	R:R:A240	R:R:V236	1.7	No	No	0	6	5
253	R:R:I105	R:R:P181	1.69	Yes	No	0	6	1
254	R:R:I308	R:R:P309	1.69	No	No	0	1	3
255	R:R:M205	R:R:P201	1.68	No	No	0	4	7
256	R:R:M243	R:R:P244	1.68	No	No	0	5	9
257	R:R:G213	R:R:Q212	1.64	No	No	0	3	5
258	R:R:S119	R:R:T120	1.6	No	Yes	0	5	6
259	R:R:T70	R:R:V66	1.59	No	No	0	4	2
260	R:R:T249	R:R:V245	1.59	No	No	0	4	6
261	R:R:T249	R:R:V286	1.59	No	No	0	4	8
262	R:R:T312	R:R:V316	1.59	No	No	0	4	1
263	R:R:T67	R:R:T70	1.57	No	No	0	3	4
264	R:R:T311	R:R:T312	1.57	No	No	0	1	4
265	R:R:I71	R:R:V316	1.54	Yes	No	0	4	1
266	R:R:I77	R:R:V78	1.54	No	No	0	5	7
267	R:R:I77	R:R:V81	1.54	No	No	0	5	5
268	R:R:I142	R:R:V143	1.54	No	No	0	5	5
269	R:R:I193	R:R:V189	1.54	No	No	0	4	4
270	R:R:H171	R:R:P172	1.53	Yes	No	0	6	7
271	R:R:K269	R:R:S268	1.53	No	No	0	1	4
272	R:R:I71	R:R:T70	1.52	Yes	No	0	4	4
273	R:R:M130	R:R:V126	1.52	No	No	0	3	5
274	R:R:K174	R:R:V173	1.52	No	No	0	4	5
275	R:R:I215	R:R:T208	1.52	No	Yes	0	4	5
276	R:R:M264	R:R:V262	1.52	No	No	0	5	6
277	R:R:I298	R:R:T294	1.52	No	No	0	6	5
278	R:R:L254	R:R:V250	1.49	No	No	0	4	4
279	R:R:I234	R:R:I238	1.47	No	No	0	4	4
280	R:R:I69	R:R:M72	1.46	No	Yes	0	4	5
281	R:R:I77	R:R:L74	1.43	No	No	0	5	5
282	R:R:I198	R:R:L232	1.43	No	No	0	4	5
283	R:R:L200	R:R:M203	1.41	No	No	0	3	4
284	R:R:D272	R:R:L275	1.36	No	No	0	3	6
285	R:R:F221	R:R:S222	1.32	No	No	0	5	6
286	R:R:R258	R:R:S261	1.32	No	No	0	5	4
287	R:R:H171	R:R:K174	1.31	Yes	No	0	6	4
288	R:R:E270	R:R:N274	1.31	No	No	0	2	5
289	R:R:R280	R:R:V284	1.31	No	No	0	6	6
290	R:R:R182	R:R:T180	1.29	No	No	0	3	7
291	R:R:F178	R:R:I167	1.26	No	No	0	4	5
292	R:R:M205	R:R:W228	1.16	No	Yes	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I71	5.174	5	3	4
2	R:R:M72	5.11	4	0	5
3	R:R:Y75	7.648	5	3	7
4	R:R:C79	4.71	4	0	6
5	R:R:V89	3.985	4	0	9
6	R:R:I105	3.305	4	0	6
7	R:R:Y106	4.708	5	0	7
8	R:R:L110	6.305	4	2	9
9	R:R:D114	7.31	5	2	9
10	R:R:T120	4.39	4	1	6
11	R:R:L121	5.45	4	0	7
12	R:R:Q124	7.1725	4	1	6
13	R:R:W133	6.4275	8	1	8
14	R:R:F135	7.758	5	1	7
15	R:R:D147	8.735	4	1	6
16	R:R:Y149	5.7425	4	4	4
17	R:R:F152	7.185	4	0	7
18	R:R:T153	6.3125	4	4	7
19	R:R:Y166	7.9675	4	6	8
20	R:R:H171	4.3625	4	6	6
21	R:R:T208	4.0125	4	1	5
22	R:R:P224	4.845	4	5	1
23	R:R:Y227	5.7825	4	5	3
24	R:R:W228	8.61	4	5	3
25	R:R:F237	5.215	4	0	5
26	R:R:Y252	5.825	6	2	9
27	R:R:W293	8.09333	6	1	8
28	R:R:H297	6.182	5	1	8
29	R:R:Y299	5.455	4	0	4
30	R:R:Q314	10	4	0	4
31	R:R:I322	5.4375	4	0	5
32	R:R:Y326	9.4325	4	1	7
33	R:R:N332	8.1825	4	2	9
34	R:R:Y336	6.354	5	2	9
35	R:R:F343	5.022	5	0	9
36	L:L:?1	8.10083	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I71	R:R:Y75	23.8742	3.63	Yes	Yes	3	4	7
2	R:R:S125	R:R:Y75	14.8894	5.09	No	Yes	0	6	7
3	R:R:M72	R:R:S125	12.4422	4.6	Yes	No	0	5	6
4	R:R:I322	R:R:Y75	46.6173	7.25	Yes	Yes	0	5	7
5	R:R:C79	R:R:L121	13.2745	4.76	Yes	Yes	0	6	7
6	R:R:L121	R:R:V78	11.0763	2.98	Yes	No	0	7	7
7	L:L:?1	R:R:I322	72.3839	4.21	Yes	Yes	0	0	5
8	L:L:?1	R:R:S329	97.9868	6.64	Yes	No	0	0	9
9	R:R:D114	R:R:S329	97.5528	11.78	Yes	No	0	9	9
10	R:R:D114	R:R:N86	100	6.73	Yes	No	0	9	9
11	R:R:N86	R:R:P333	96.4715	8.15	No	No	0	9	9
12	R:R:P333	R:R:V89	94.7286	3.53	No	Yes	0	9	9
13	R:R:F338	R:R:V89	12.1576	3.93	No	Yes	0	6	9
14	R:R:A337	R:R:V89	82.5781	5.09	No	Yes	0	7	9
15	R:R:A337	R:R:F343	80.8067	4.16	No	Yes	0	7	9
16	R:R:F343	R:R:I93	50.5158	5.02	Yes	No	0	9	7
17	R:R:F108	R:R:I93	48.3958	6.28	No	No	0	6	7
18	R:R:F108	R:R:M99	39.66	8.71	No	No	0	6	7
19	R:R:I105	R:R:M99	37.4404	4.37	Yes	No	0	6	7
20	R:R:I105	R:R:N109	21.5053	4.25	Yes	No	0	6	9
21	L:L:?1	R:R:M151	22.238	4.17	Yes	No	1	0	7
22	R:R:F152	R:R:M151	26.0582	3.73	Yes	No	0	7	7
23	R:R:F152	R:R:F156	16.7532	8.57	Yes	No	0	7	6
24	R:R:F156	R:R:N191	13.5377	4.83	No	No	0	6	7
25	R:R:N191	R:R:T160	12.2999	7.31	No	No	0	7	7
26	R:R:T160	R:R:Y106	11.9869	4.99	No	Yes	0	7	7
27	L:L:?1	R:R:W293	57.7292	11.75	Yes	Yes	1	0	8
28	R:R:N328	R:R:W293	28.0928	7.91	No	Yes	0	9	8
29	R:R:N328	R:R:N332	25.4749	8.17	No	Yes	0	9	9
30	R:R:L158	R:R:N332	51.2271	8.24	No	Yes	2	8	9
31	R:R:L158	R:R:Y336	80.3728	4.69	No	Yes	2	8	9
32	R:R:M161	R:R:Y336	16.8101	8.38	No	Yes	0	8	9
33	R:R:D114	R:R:N332	37.4049	8.08	Yes	Yes	2	9	9
34	R:R:D114	R:R:L110	34.6304	4.07	Yes	Yes	2	9	9
35	R:R:L110	R:R:L158	32.4963	5.54	Yes	No	2	9	8
36	R:R:D164	R:R:Y106	10.1515	5.75	No	Yes	0	8	7
37	R:R:D340	R:R:F343	23.8244	7.17	No	Yes	0	8	9
38	R:R:N109	R:R:N188	19.1719	19.07	No	No	0	9	7
39	R:R:L121	R:R:Y326	25.1974	7.03	Yes	Yes	0	7	7
40	R:R:Q124	R:R:T120	13.8579	4.25	Yes	Yes	1	6	6
41	R:R:I146	R:R:T120	18.7736	3.04	No	Yes	0	5	6
42	R:R:I146	R:R:N150	14.0997	4.25	No	No	0	5	8
43	L:L:?1	R:R:Q124	14.2278	14.71	Yes	Yes	1	0	6
44	R:R:D147	R:R:T120	14.0357	8.67	Yes	Yes	1	6	6
45	L:L:?1	R:R:D147	14.6333	13	Yes	Yes	1	0	6
46	L:L:?1	R:R:W133	71.7863	4.2	Yes	Yes	1	0	8
47	R:R:C140	R:R:W133	27.1039	5.22	No	Yes	1	9	8
48	R:R:C140	R:R:T208	25.0907	5.07	No	Yes	1	9	5
49	R:R:I215	R:R:T208	12.8192	1.52	No	Yes	0	4	5
50	R:R:C217	R:R:W133	26.9332	6.53	No	Yes	1	9	8
51	R:R:C217	R:R:T208	25.0907	5.07	No	Yes	1	9	5
52	R:R:N137	R:R:T208	33.5705	4.39	No	Yes	0	1	5
53	R:R:K141	R:R:N137	29.3804	9.79	No	No	0	6	1
54	L:L:?1	R:R:I144	42.036	6.31	Yes	No	0	0	5
55	R:R:I144	R:R:V202	38.5715	3.07	No	No	0	5	5
56	R:R:S145	R:R:V202	34.4882	4.85	No	No	0	6	5
57	R:R:N188	R:R:W192	16.8244	9.04	No	No	0	7	9
58	R:R:I155	R:R:W293	12.2288	5.87	No	Yes	0	8	8
59	R:R:F289	R:R:W293	38.7209	12.03	No	Yes	0	9	8
60	R:R:F289	R:R:I248	37.1416	5.02	No	No	0	9	8
61	R:R:I248	R:R:S162	35.7117	6.19	No	No	0	8	9
62	R:R:C251	R:R:S162	38.977	5.16	No	No	0	7	9
63	R:R:S162	R:R:Y252	33.9333	5.09	No	Yes	0	9	9
64	R:R:C251	R:R:Y166	27.8793	6.72	No	Yes	0	7	8
65	R:R:C170	R:R:Y166	11.6028	9.41	No	Yes	6	7	8
66	R:R:M255	R:R:Y252	14.1922	3.59	No	Yes	0	8	9
67	R:R:I105	R:R:P181	12.0865	1.69	Yes	No	0	6	1
68	R:R:M203	R:R:S145	30.3479	3.07	No	No	0	4	6
69	R:R:L200	R:R:M203	28.2564	1.41	No	No	0	3	4
70	R:R:K141	R:R:T207	25.1761	3	No	No	0	6	5
71	R:R:K209	R:R:T207	20.9575	10.51	No	No	0	3	5
72	R:R:K209	R:R:T218	16.7248	4.5	No	No	0	3	3
73	R:R:D216	R:R:T218	12.4778	2.89	No	No	0	4	3
74	L:L:?1	R:R:V300	13.0398	3.29	Yes	No	0	0	5
75	R:R:K233	R:R:V300	11.0123	3.04	No	No	0	4	5
76	R:R:L200	R:R:P201	24.0307	3.28	No	No	0	3	7
77	R:R:M205	R:R:P201	21.8966	1.68	No	No	0	4	7
78	R:R:M205	R:R:W228	19.7482	1.16	No	Yes	0	4	3
79	R:R:F237	R:R:H297	20.2533	4.53	Yes	Yes	0	5	8
80	L:L:?1	R:R:H297	30.3052	4.74	Yes	Yes	1	0	8
81	R:R:F241	R:R:H297	24.3935	11.31	No	Yes	0	8	8
82	R:R:F241	R:R:V245	11.1902	3.93	No	No	0	8	6
83	R:R:F241	R:R:T294	17.3721	10.38	No	No	0	8	5
84	R:R:V282	R:R:Y252	11.8162	10.09	No	Yes	0	7	9
85	R:R:V285	R:R:Y336	47.3999	7.57	No	Yes	0	8	9
86	R:R:L335	R:R:V285	43.4801	5.96	No	No	0	8	8
87	R:R:L335	R:R:V284	35.541	2.98	No	No	0	8	6
88	R:R:R280	R:R:V284	31.8062	1.31	No	No	0	6	6
89	R:R:R276	R:R:R280	28.4769	6.4	No	No	0	5	6
90	R:R:R273	R:R:R276	25.1974	2.13	No	No	0	4	5
91	R:R:K269	R:R:R273	11.8162	6.19	No	No	0	1	4
92	R:R:E270	R:R:R273	12.3639	6.98	No	No	0	2	4
93	R:R:D340	R:R:N342	17.3294	8.08	No	No	0	8	6
94	R:R:N342	R:R:R345	15.1739	3.62	No	No	0	6	4
95	R:R:E341	R:R:R345	13.3314	2.33	No	No	0	4	4
96	R:R:I322	R:R:W318	36.4516	5.87	Yes	No	0	5	5
97	R:R:W318	R:R:Y299	20.5236	5.79	No	Yes	0	5	4
98	R:R:Q314	R:R:Y299	11.5316	5.64	Yes	Yes	0	4	4
99	R:R:K303	R:R:W318	13.7298	10.44	No	No	0	4	5
100	R:R:K303	R:R:Q314	11.6312	4.07	No	Yes	0	4	4
101	L:L:?1	R:R:Y326	23.6181	18.14	Yes	Yes	1	0	7
102	R:R:M161	R:R:Y106	12.8833	4.79	No	Yes	0	8	7
103	R:R:Y252	R:R:Y336	32.1335	4.96	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L121	R:R:Y75	7.03	0	Yes	Yes	7	7	2	2
R:R:I322	R:R:Y75	7.25	0	Yes	Yes	5	7	1	2
R:R:D114	R:R:S329	11.78	2	Yes	No	9	9	2	1
R:R:Q124	R:R:T120	4.25	1	Yes	Yes	6	6	1	2
R:R:D147	R:R:T120	8.67	1	Yes	Yes	6	6	1	2
R:R:L121	R:R:Y326	7.03	0	Yes	Yes	7	7	2	1
R:R:F123	R:R:W133	5.01	1	No	Yes	6	8	2	1
R:R:F123	R:R:F135	7.5	1	No	Yes	6	7	2	2
R:R:F123	R:R:V143	5.24	1	No	No	6	5	2	2
R:R:D147	R:R:Q124	5.22	1	Yes	Yes	6	6	1	1
R:R:Q124	R:R:Y326	4.51	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:Q124	14.71	1	Yes	Yes	0	6	0	1
R:R:N127	R:R:W133	7.91	0	No	Yes	6	8	2	1
R:R:P134	R:R:W133	5.4	1	No	Yes	4	8	2	1
R:R:F135	R:R:W133	11.02	1	Yes	Yes	7	8	2	1
R:R:C140	R:R:W133	5.22	1	No	Yes	9	8	2	1
R:R:V143	R:R:W133	6.13	1	No	Yes	5	8	2	1
R:R:C217	R:R:W133	6.53	1	No	Yes	9	8	2	1
L:L:?1	R:R:W133	4.2	1	Yes	Yes	0	8	0	1
R:R:F135	R:R:P134	11.56	1	Yes	No	7	4	2	2
R:R:C140	R:R:C217	5.46	1	No	No	9	9	2	2
R:R:I144	R:R:L219	5.71	0	No	No	5	5	1	2
L:L:?1	R:R:I144	6.31	1	Yes	No	0	5	0	1
R:R:D147	R:R:Y326	8.05	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:D147	13	1	Yes	Yes	0	6	0	1
R:R:L219	R:R:Y148	4.69	0	No	No	5	4	2	1
L:L:?1	R:R:Y148	6.05	1	Yes	No	0	4	0	1
R:R:F152	R:R:M151	3.73	0	Yes	No	7	7	2	1
R:R:M151	R:R:W293	4.65	1	No	Yes	7	8	1	1
L:L:?1	R:R:M151	4.17	1	Yes	No	0	7	0	1
R:R:I155	R:R:W293	5.87	0	No	Yes	8	8	2	1
R:R:F237	R:R:H297	4.53	0	Yes	Yes	5	8	2	1
R:R:F241	R:R:H297	11.31	0	No	Yes	8	8	2	1
R:R:F289	R:R:W293	12.03	0	No	Yes	9	8	2	1
R:R:H297	R:R:W293	6.35	1	Yes	Yes	8	8	1	1
R:R:N328	R:R:W293	7.91	0	No	Yes	9	8	2	1
L:L:?1	R:R:W293	11.75	1	Yes	Yes	0	8	0	1
R:R:H297	R:R:I296	3.98	1	Yes	No	8	6	1	2
R:R:I296	R:R:I322	4.42	0	No	Yes	6	5	2	1
L:L:?1	R:R:H297	4.74	1	Yes	Yes	0	8	0	1
R:R:I322	R:R:W318	5.87	0	Yes	No	5	5	1	2
L:L:?1	R:R:I322	4.21	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y326	18.14	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S329	6.64	1	Yes	No	0	9	0	1
L:L:?1	R:R:V300	3.29	1	Yes	No	0	5	0	1
R:R:I144	R:R:V202	3.07	0	No	No	5	5	1	2
R:R:K233	R:R:V300	3.04	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7U2L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	266
Number of Links	292
Number of Hubs	36
Number of Links mediated by Hubs	138
Number of Communities	6
Number of Nodes involved in Communities	38
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	48940
Length Of Smallest Path	3
Average Path Length	12.1518
Length of Longest Path	28
Minimum Path Strength	1.415
Average Path Strength	5.99371
Maximum Path Strength	15.145
Minimum Path Correlation	0.7
Average Path Correlation	0.926905
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	52.6283
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.2458
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	L0X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	L0X
Name	N-(5-carbamimidamidopentyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Synonyms
Identifier
Formula	C22 H37 N5 O
Molecular Weight	387.562
SMILES
PubChem	163201242
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	0
Total Bonds	66
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>7U2L_nogp_Chain_R M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

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