Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y1 8.55333600
2L:L:?2 8.9175400
3L:L:?4 11.32500
4R:R:Y75 6.285407
5R:R:C79 3.93406
6R:R:V89 3.7875409
7R:R:I93 4.83407
8R:R:Y106 5.2325407
9R:R:D114 6.754519
10R:R:L121 4.865407
11R:R:Y128 7.664565
12R:R:W133 8.73286748
13R:R:F152 5.354577
14R:R:T153 6.72437
15R:R:F156 4.44576
16R:R:Y166 6.415488
17R:R:H171 3.4475486
18R:R:W192 9.3539
19R:R:F221 10.77405
20R:R:F237 5.975455
21R:R:F241 6.4225458
22R:R:P244 2.82409
23R:R:Y252 8.5325409
24R:R:I256 2.335405
25R:R:F289 4.9875419
26R:R:W293 7.554518
27R:R:H297 7.155458
28R:R:Q314 6.86424
29R:R:W318 7.8575425
30R:R:N328 7.87419
31R:R:N332 7.33519
32R:R:L335 2.2075408
33R:R:Y336 5.27167619
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?2 L:L:Y1 10010.73YesYes000
2L:L:Y1 R:R:V236 44.90845.05YesNo005
3L:L:Y1 R:R:H297 92.52066.53YesYes008
4L:L:Y1 R:R:V300 20.918310.09YesNo005
5L:L:?2 R:R:I322 44.24458.71YesNo005
6R:R:I322 R:R:Y75 27.29384.84NoYes057
7L:L:?2 L:L:G3 49.6526.96YesNo000
8L:L:?4 L:L:G3 48.35618.88YesNo000
9R:R:H319 R:R:I322 23.45413.98NoNo045
10R:R:H319 R:R:Y128 21.350311.98NoYes045
11R:R:I71 R:R:Y128 12.9838.46NoYes645
12R:R:L121 R:R:Y75 23.12617.03YesYes077
13R:R:H297 R:R:I296 81.82553.98YesNo086
14R:R:I296 R:R:W293 81.34553.52NoYes068
15R:R:N328 R:R:W293 31.549514.69YesYes198
16R:R:N328 R:R:N332 43.78854.09YesYes199
17R:R:D114 R:R:N332 39.08494.04YesYes199
18R:R:D114 R:R:S329 19.350510.31YesNo099
19R:R:S329 R:R:T118 15.60684.8NoNo096
20R:R:D114 R:R:N86 28.42975.39YesNo099
21R:R:N86 R:R:P333 24.8466.52NoNo099
22R:R:P333 R:R:V89 23.03025.3NoYes099
23R:R:I93 R:R:V89 17.48663.07YesYes079
24R:R:F152 R:R:V236 43.66855.24YesNo075
25R:R:F152 R:R:F156 37.7654.29YesYes776
26R:R:F156 R:R:N191 27.01383.62YesNo067
27R:R:N191 R:R:T160 32.49347.31NoNo077
28R:R:T160 R:R:Y106 30.70956.24NoYes077
29R:R:A184 R:R:Y106 19.67044NoYes077
30R:R:A102 R:R:A184 17.77461.79NoNo067
31R:R:A102 R:R:P181 15.86275.61NoNo061
32R:R:N188 R:R:N191 27.01384.09NoNo077
33R:R:N109 R:R:N188 21.550317.71NoNo397
34R:R:N109 R:R:T157 32.709414.62NoNo097
35R:R:L110 R:R:N332 25.16610.98NoYes199
36R:R:L110 R:R:T157 33.35734.42NoNo097
37R:R:F156 R:R:S195 12.3995.28YesNo068
38R:R:S195 R:R:T153 12.0156.4NoYes087
39L:L:?4 R:R:W133 48.75613.94YesYes008
40R:R:N127 R:R:W133 27.87786.78NoYes068
41R:R:N127 R:R:V126 25.98992.96NoNo065
42R:R:P134 R:R:V126 20.23047.07NoNo045
43R:R:P134 R:R:T132 18.27856.99NoNo045
44R:R:C217 R:R:W133 10.311222.2NoYes098
45R:R:F289 R:R:W293 42.57267.02YesYes198
46R:R:F289 R:R:P244 13.52694.33YesYes099
47R:R:N332 R:R:Y336 32.08549.3YesYes199
48R:R:R165 R:R:Y336 28.01384.12NoYes199
49R:R:F289 R:R:I248 45.21243.77YesNo098
50R:R:I248 R:R:S162 43.98856.19NoNo089
51R:R:C251 R:R:S162 26.03795.16NoNo079
52R:R:S162 R:R:Y252 35.445215.26NoYes099
53R:R:C251 R:R:Y166 19.12652.69NoYes078
54R:R:H171 R:R:Y166 12.0316.53YesYes868
55R:R:M255 R:R:Y252 32.30944.79NoYes089
56R:R:M255 R:R:V169 30.50167.61NoNo088
57R:R:K233 R:R:V300 19.18251.52NoNo045
58R:R:E229 R:R:K233 15.430812.15NoNo044
59R:R:E229 R:R:F221 13.71097NoYes045
60R:R:S214 R:R:T132 12.3273.2NoNo025
61R:R:F241 R:R:H297 26.581913.58YesYes588
62R:R:F241 R:R:V245 10.79113.93YesNo086
63R:R:F241 R:R:T294 21.51033.89YesNo085
64R:R:V282 R:R:Y252 15.72673.79NoYes079
65R:R:I256 R:R:V282 13.97494.61YesNo057
66R:R:R258 R:R:V169 25.352.62NoNo058
67R:R:R258 R:R:V262 21.63832.62NoNo056
68R:R:M264 R:R:V262 19.75041.52NoNo056
69R:R:L265 R:R:M264 10.07122.83NoNo035
70R:R:I290 R:R:V245 10.03921.54NoNo056
71R:R:P295 R:R:T294 10.95116.99NoNo095
72L:L:?2 R:R:W318 14.59089.27YesYes005
73R:R:W318 R:R:Y299 11.367112.54YesNo254
74R:R:I71 R:R:T67 10.88713.04NoNo043
75R:R:M243 R:R:P244 11.41511.68NoYes059
76R:R:N109 R:R:W192 11.287111.3NoYes399
77R:R:F289 R:R:N328 12.2474.83YesYes199
78R:R:R165 R:R:Y252 27.165810.29NoYes099
79R:R:V285 R:R:Y336 10.41526.31NoYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y1 R:R:Y148 6.95 0 Yes No 0 4 0 1
L:L:Y1 R:R:M151 11.97 0 Yes No 0 7 0 1
L:L:Y1 R:R:V236 5.05 0 Yes No 0 5 0 1
L:L:Y1 R:R:H297 6.53 0 Yes Yes 0 8 0 1
L:L:Y1 R:R:V300 10.09 0 Yes No 0 5 0 1
L:L:?2 R:R:W318 9.27 0 Yes Yes 0 5 0 1
L:L:?2 R:R:I322 8.71 0 Yes No 0 5 0 1
L:L:?4 R:R:Q124 9.21 0 Yes No 0 6 0 1
L:L:?4 R:R:W133 3.94 0 Yes Yes 0 8 0 1
L:L:?4 R:R:I144 13.58 0 Yes No 0 5 0 1
L:L:?5 R:R:K303 5.7 2 No No 0 4 0 1
L:L:?5 R:R:W318 6.14 2 No Yes 0 5 0 1
R:R:Q124 R:R:Y75 5.64 0 No Yes 6 7 1 2
R:R:I322 R:R:Y75 4.84 0 No Yes 5 7 1 2
R:R:F123 R:R:W133 5.01 4 No Yes 6 8 2 1
R:R:F123 R:R:F135 6.43 4 No No 6 7 2 2
R:R:F123 R:R:V143 13.11 4 No No 6 5 2 2
R:R:N127 R:R:W133 6.78 0 No Yes 6 8 2 1
R:R:F135 R:R:W133 13.03 4 No Yes 7 8 2 1
R:R:V143 R:R:W133 7.36 4 No Yes 5 8 2 1
R:R:C217 R:R:W133 22.2 0 No Yes 9 8 2 1
R:R:A206 R:R:I144 4.87 0 No No 4 5 2 1
R:R:I144 R:R:L219 4.28 0 No No 5 5 1 2
R:R:V202 R:R:Y148 11.36 0 No No 5 4 2 1
R:R:F152 R:R:V236 5.24 7 Yes No 7 5 2 1
R:R:F237 R:R:F241 4.29 5 Yes Yes 5 8 2 2
R:R:F237 R:R:H297 4.53 5 Yes Yes 5 8 2 1
R:R:F241 R:R:H297 13.58 5 Yes Yes 8 8 2 1
R:R:H297 R:R:I296 3.98 5 Yes No 8 6 1 2
R:R:W318 R:R:Y299 12.54 2 Yes No 5 4 1 2
R:R:K303 R:R:W318 3.48 2 No Yes 4 5 1 1
R:R:H319 R:R:I322 3.98 0 No No 4 5 2 1
R:R:G136 R:R:W133 2.81 0 No Yes 7 8 2 1
R:R:K233 R:R:V300 1.52 0 No No 4 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6DDE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.36
Number of Linked Nodes 265
Number of Links 278
Number of Hubs 33
Number of Links mediated by Hubs 127
Number of Communities 8
Number of Nodes involved in Communities 38
Number of Links involved in Communities 45
Path Summary
Number Of Nodes in MetaPath 80
Number Of Links MetaPath 79
Number of Shortest Paths 31310
Length Of Smallest Path 3
Average Path Length 12.3729
Length of Longest Path 29
Minimum Path Strength 1.375
Average Path Strength 6.24687
Maximum Path Strength 17.615
Minimum Path Correlation 0.7
Average Path Correlation 0.923866
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 56.1024
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.0288
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDAL
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeDAL
NameD-Alanine
SynonymsD-Alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0

CodeMEA
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeMEA
NameN-METHYLPHENYLALANINE
Synonyms
Identifier
FormulaC10 H13 N O2
Molecular Weight179.216
SMILES
PubChem6951135
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6

CodeETA
PDB ResiduesL:L:?5
Environment DetailsOpen EMBL-EBI Page
CodeETA
NameEthanolamine
SynonymsEthanolamine
Identifier
FormulaC2 H7 N O
Molecular Weight61.083
SMILES
PubChem700
Formal Charge0
Total Atoms11
Total Chiral Atoms0
Total Bonds10
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP42866
Sequence
>6DDE_nogp_Chain_R
MVTAITIMA LYSIVCVVG LFGNFLVMY VIVRYTKMK TATNIYIFN 
LALADALAT STLPFQSVN YLMGTWPFG NILCKIVIS IDYYNMFTS 
IFTLCTMSV DRYIAVCHP VKALDFRTP RNAKIVNVC NWILSSAIG 
LPVMFMATT KYRQGSIDC TLTFSHPTW YWENLLKIC VFIFAFIMP 
VLIITVCYG LMILRLKSV RMLSGSKEK DRNLRRITR MVLVVVAVF 
IVCWTPIHI YVIIKALIT IPETTFQTV SWHFCIALG YTNSCLNPV 
LYAFLDENF KR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4DKLAPeptideOpioidμMus musculusβ-Funaltrexamine--2.82012-03-21doi.org/10.1038/nature10954
5C1MAPeptideOpioidμMus musculusBU72--2.072015-08-05doi.org/10.1038/nature14886
6DDEAPeptideOpioidμMus musculusDAMGO-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDE (No Gprot) APeptideOpioidμMus musculusDAMGO-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDFAPeptideOpioidμMus musculusDAMGO-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDF (No Gprot) APeptideOpioidμMus musculusDAMGO-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
7SBFAPeptideOpioidμMus musculusPZM21-Gi1/β1/γ22.92022-04-20doi.org/10.1002/anie.202200269
7SBF (No Gprot) APeptideOpioidμMus musculusPZM21-2.92022-04-20doi.org/10.1002/anie.202200269
7SCGAPeptideOpioidμMus musculusFH210-Gi1/β1/γ232022-04-20doi.org/10.1002/anie.202200269
7SCG (No Gprot) APeptideOpioidμMus musculusFH210-32022-04-20doi.org/10.1002/anie.202200269
7U2LAPeptideOpioidμMus musculusC5-guano-Gi1/β1/γ23.22022-05-04doi.org/10.1038/s41586-022-05588-y
7U2L (No Gprot) APeptideOpioidμMus musculusC5-guano-3.22022-05-04doi.org/10.1038/s41586-022-05588-y
7UL4APeptideOpioidμMus musculusAlvimopan--2.82022-06-29doi.org/10.1038/s41594-022-00859-8
8EF5APeptideOpioidμHomo sapiensFentanyl-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF5 (No Gprot) APeptideOpioidμHomo sapiensFentanyl-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6APeptideOpioidμHomo sapiensMorphine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6 (No Gprot) APeptideOpioidμHomo sapiensMorphine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFBAPeptideOpioidμHomo sapiensOliceridine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFB (No Gprot) APeptideOpioidμHomo sapiensOliceridine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFLAPeptideOpioidμHomo sapiensSR17018-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFL (No Gprot) APeptideOpioidμHomo sapiensSR17018-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFOAPeptideOpioidμHomo sapiensPZM21-Gi1/β1/γ22.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFO (No Gprot) APeptideOpioidμHomo sapiensPZM21-2.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQAPeptideOpioidμHomo sapiensDAMGO-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQ (No Gprot) APeptideOpioidμHomo sapiensDAMGO-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
7T2GAPeptideOpioidμMus musculusMitragynine Pseudoindoxyl-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2G (No Gprot) APeptideOpioidμMus musculusMitragynine Pseudoindoxyl-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2HAPeptideOpioidμMus musculusLofentanil-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2H (No Gprot) APeptideOpioidμMus musculusLofentanil-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7U2KAPeptideOpioidμMus musculusC6-guano-Gi1/β1/γ23.32022-12-07doi.org/10.1038/s41586-022-05588-y
7U2K (No Gprot) APeptideOpioidμMus musculusC6-guano-3.32022-12-07doi.org/10.1038/s41586-022-05588-y
8F7QAPeptideOpioidμHomo sapiensβ-Endorphin-Gi1/β1/γ23.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7Q (No Gprot) APeptideOpioidμHomo sapiensβ-Endorphin-3.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7RAPeptideOpioidμHomo sapiensEndomorphin-Gi1/β1/γ23.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7R (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-3.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8K9KAPeptideOpioidμHomo sapiensDAMGO-Gi3/β1/γ12.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9K (No Gprot) APeptideOpioidμHomo sapiensDAMGO-2.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9LAPeptideOpioidμHomo sapiensDAMGOBMS-986122Gi3/β1/γ13.052024-05-29doi.org/10.1038/s41467-024-47792-6
8K9L (No Gprot) APeptideOpioidμHomo sapiensDAMGOBMS-9861223.052024-05-29doi.org/10.1038/s41467-024-47792-6
9BJKAPeptideOpioidμMus musculusNaloxonePubChem 171642066-3.262024-07-17doi.org/10.1038/s41586-024-07587-7
9BQJAPeptideOpioidμMus musculusRO76-Gi1/β1/γ23.32024-09-11doi.org/10.1021/acscentsci.4c00525
9BQJ (No Gprot) APeptideOpioidμMus musculusRO76-3.32024-09-11doi.org/10.1021/acscentsci.4c00525
9MQHAPeptideOpioidμHomo sapiens---3.92025-02-12doi.org/10.1101/2025.01.09.632033
9MQIAPeptideOpioidμHomo sapiensIsoquinuclidine--3.32025-02-12doi.org/10.1101/2025.01.09.632033
9MQJAPeptideOpioidμHomo sapiensIsoquinuclidine--3.232025-02-12doi.org/10.1101/2025.01.09.632033
9WSTAPeptideOpioidμHomo sapiensDAMGO-chim(NtGi1-Gz)/β1/γ22.82025-11-2610.1038/s41422-025-01191-8
9WST (No Gprot) APeptideOpioidμHomo sapiensDAMGO-2.82025-11-2610.1038/s41422-025-01191-8
9WSVAPeptideOpioidμHomo sapiensDAMGO-Arrestin22.82025-11-2610.1038/s41422-025-01191-8
9WSV (No Gprot) APeptideOpioidμHomo sapiensDAMGO-2.82025-11-2610.1038/s41422-025-01191-8
9WSWAPeptideOpioidμHomo sapiensEndomorphin-chim(NtGi1-Gz)/β1/γ22.82025-11-2610.1038/s41422-025-01191-8
9WSW (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-2.82025-11-2610.1038/s41422-025-01191-8
9WSXAPeptideOpioidμHomo sapiensEndomorphin-Arrestin22.82025-11-2610.1038/s41422-025-01191-8
9WSX (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-2.82025-11-2610.1038/s41422-025-01191-8
8E0GAPeptideOpioidμMus musculusBU72--2.12023-10-18doi.org/10.1186/s12915-023-01689-w
8QOTAPeptideOpioidμMus musculusNanobody-E--3.22023-12-27doi.org/10.1101/2023.12.06.570395
8Y72APeptideOpioidμHomo sapiensPeptideBMS-986122Gi1/β1/γ22.652025-08-06To be published
8Y72 (No Gprot) APeptideOpioidμHomo sapiensPeptideBMS-9861222.652025-08-06To be published
8Y73APeptideOpioidμHomo sapiensPeptideMPAM-15Gi1/β1/γ22.842025-08-06To be published
8Y73 (No Gprot) APeptideOpioidμHomo sapiensPeptideMPAM-152.842025-08-06To be published
9PXUAPeptideOpioidμHomo sapiensNaloxoneNa-3.42025-11-1210.1038/s41586-025-09677-6
9PXVAPeptideOpioidμHomo sapiensNaloxone-Gi1/β1/γ23.022025-11-1210.1038/s41586-025-09677-6
9PXV (No Gprot) APeptideOpioidμHomo sapiensNaloxone-3.022025-11-1210.1038/s41586-025-09677-6
9PXWAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ23.82025-11-1210.1038/s41586-025-09677-6
9PXW (No Gprot) APeptideOpioidμHomo sapiensNaloxoneGDPβS3.82025-11-1210.1038/s41586-025-09677-6
9PXXAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ23.12025-11-1210.1038/s41586-025-09677-6
9PXX (No Gprot) APeptideOpioidμHomo sapiensNaloxoneGDPβS3.12025-11-1210.1038/s41586-025-09677-6
9PXYAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ232025-11-1210.1038/s41586-025-09677-6
9PXY (No Gprot) APeptideOpioidμHomo sapiensNaloxoneGDPβS32025-11-1210.1038/s41586-025-09677-6
9PY2APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ23.162025-11-1210.1038/s41586-025-09677-6
9PY2 (No Gprot) APeptideOpioidμHomo sapiensLoperamideGDPβS3.162025-11-1210.1038/s41586-025-09677-6
9PY3APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ23.22025-11-12To be published
9PY3 (No Gprot) APeptideOpioidμHomo sapiensLoperamideGDPβS3.22025-11-12To be published
9PY4APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ22.782025-11-1210.1038/s41586-025-09677-6
9PY4 (No Gprot) APeptideOpioidμHomo sapiensLoperamideGDPβS2.782025-11-1210.1038/s41586-025-09677-6
9ODJAPeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; MgGi1/β1/γ232026-01-0710.1038/s41586-025-10056-4
9ODJ (No Gprot) APeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; Mg32026-01-0710.1038/s41586-025-10056-4
9ODKAPeptideOpioidμMus musculus-GTP; MgGi1/β1/γ23.92026-01-0710.1038/s41586-025-10056-4
9ODK (No Gprot) APeptideOpioidμMus musculus-GTP; Mg3.92026-01-0710.1038/s41586-025-10056-4
9ODLAPeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; MgGi1/β1/γ23.62026-01-0710.1038/s41586-025-10056-4
9ODL (No Gprot) APeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; Mg3.62026-01-0710.1038/s41586-025-10056-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6DDE_nogp.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.