psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I69	R:R:L129	4.28	No	No	0	4	5
2	R:R:L129	R:R:M72	4.24	No	No	0	5	5
3	R:R:Q124	R:R:Y75	4.51	No	Yes	0	6	7
4	R:R:H319	R:R:Y75	3.27	No	Yes	0	4	7
5	R:R:I322	R:R:Y75	7.25	No	Yes	0	5	7
6	R:R:C79	R:R:L121	4.76	No	No	0	6	7
7	R:R:C79	R:R:P122	7.53	No	No	0	6	8
8	R:R:F84	R:R:V80	7.87	No	No	0	4	5
9	R:R:C330	R:R:V81	3.42	No	No	0	7	5
10	R:R:C330	R:R:G82	3.92	No	No	0	7	8
11	R:R:F87	R:R:L83	14.61	No	No	0	4	6
12	R:R:G85	R:R:P333	4.06	No	No	0	7	9
13	R:R:D114	R:R:N86	6.73	Yes	No	0	9	9
14	R:R:N86	R:R:P333	11.4	No	No	0	9	9
15	R:R:F87	R:R:M90	3.73	No	No	0	4	7
16	R:R:A111	R:R:V89	3.39	No	No	0	9	9
17	R:R:P333	R:R:V89	3.53	No	No	0	9	9
18	R:R:A337	R:R:V89	5.09	No	No	0	7	9
19	R:R:F108	R:R:M90	4.98	No	No	0	6	7
20	R:R:R95	R:R:Y91	9.26	Yes	No	0	4	4
21	R:R:V92	R:R:Y96	6.31	No	No	0	7	5
22	R:R:I93	R:R:T97	9.12	Yes	No	4	7	6
23	R:R:I93	R:R:N104	5.66	Yes	No	4	7	8
24	R:R:F108	R:R:I93	5.02	No	Yes	0	6	7
25	R:R:R95	R:R:V94	6.54	Yes	No	0	4	3
26	R:R:F108	R:R:V94	3.93	No	No	0	6	3
27	R:R:K98	R:R:R95	4.95	No	Yes	0	5	4
28	R:R:N104	R:R:T97	14.62	No	No	4	8	6
29	R:R:R345	R:R:T97	6.47	No	No	0	4	6
30	R:R:K100	R:R:K98	5.75	No	No	0	6	5
31	R:R:N104	R:R:T101	4.39	No	No	0	8	8
32	R:R:R179	R:R:T103	3.88	No	No	0	6	8
33	R:R:T160	R:R:Y106	6.24	No	Yes	5	7	7
34	R:R:D164	R:R:Y106	11.49	No	Yes	0	8	7
35	R:R:A184	R:R:Y106	4	No	Yes	0	7	7
36	R:R:V187	R:R:Y106	3.79	No	Yes	5	5	7
37	R:R:N109	R:R:T157	13.16	No	No	0	9	7
38	R:R:N109	R:R:N188	17.71	No	No	6	9	7
39	R:R:N109	R:R:W192	13.56	No	Yes	6	9	9
40	R:R:D114	R:R:L110	9.5	Yes	Yes	1	9	9
41	R:R:L110	R:R:T157	5.9	Yes	No	0	9	7
42	R:R:L110	R:R:L158	5.54	Yes	No	0	9	8
43	R:R:L110	R:R:N332	10.98	Yes	Yes	1	9	9
44	R:R:A113	R:R:T153	3.36	No	No	0	8	7
45	R:R:D114	R:R:S154	7.36	Yes	No	0	9	9
46	R:R:D114	R:R:S329	8.83	Yes	No	0	9	9
47	R:R:D114	R:R:N332	6.73	Yes	Yes	1	9	9
48	R:R:I146	R:R:L116	4.28	No	No	0	5	7
49	R:R:L116	R:R:N150	10.98	No	No	0	7	8
50	R:R:S329	R:R:T118	4.8	No	No	0	9	6
51	R:R:Q124	R:R:T120	4.25	No	No	0	6	6
52	R:R:I146	R:R:T120	4.56	No	No	0	5	6
53	R:R:L121	R:R:Y326	11.72	No	No	0	7	7
54	R:R:F123	R:R:F135	11.79	No	Yes	0	6	7
55	R:R:F123	R:R:V143	5.24	No	No	0	6	5
56	L:L:?4	R:R:Q124	6.91	Yes	No	0	0	6
57	R:R:P134	R:R:V126	7.07	No	No	0	4	5
58	R:R:F135	R:R:V126	5.24	Yes	No	0	7	5
59	R:R:N127	R:R:W133	6.78	No	Yes	0	6	8
60	R:R:T315	R:R:Y128	7.49	No	Yes	0	4	5
61	R:R:H319	R:R:Y128	10.89	No	Yes	0	4	5
62	R:R:M130	R:R:P134	3.35	No	No	0	3	4
63	R:R:P134	R:R:T132	6.99	No	No	0	4	5
64	R:R:S214	R:R:T132	4.8	No	No	0	2	5
65	R:R:F135	R:R:W133	19.04	Yes	Yes	0	7	8
66	R:R:C140	R:R:W133	6.53	Yes	Yes	2	9	8
67	R:R:V143	R:R:W133	7.36	No	Yes	2	5	8
68	R:R:C217	R:R:W133	20.89	Yes	Yes	2	9	8
69	L:L:?4	R:R:W133	4.93	Yes	Yes	2	0	8
70	R:R:F135	R:R:L139	4.87	Yes	No	0	7	6
71	R:R:K141	R:R:N137	11.19	No	No	0	6	1
72	R:R:N137	R:R:T208	10.24	No	No	0	1	5
73	R:R:C140	R:R:I144	3.27	Yes	Yes	2	9	5
74	R:R:C140	R:R:T208	3.38	Yes	No	0	9	5
75	R:R:C140	R:R:C217	7.28	Yes	Yes	2	9	9
76	L:L:?4	R:R:V143	3.87	Yes	No	2	0	5
77	R:R:A206	R:R:I144	6.5	No	Yes	0	4	5
78	R:R:C217	R:R:I144	3.27	Yes	Yes	2	9	5
79	L:L:?4	R:R:I144	11.11	Yes	Yes	2	0	5
80	R:R:M203	R:R:S145	9.2	No	No	0	4	6
81	R:R:D147	R:R:Y148	3.45	No	No	0	6	4
82	R:R:D147	R:R:Y326	5.75	No	No	0	6	7
83	L:L:?4	R:R:D147	3.52	Yes	No	0	0	6
84	R:R:V202	R:R:Y148	12.62	No	No	0	5	4
85	L:L:Y1	R:R:Y148	6.95	Yes	No	0	0	4
86	R:R:N150	R:R:Y149	3.49	No	No	0	8	4
87	R:R:W192	R:R:Y149	10.61	Yes	No	0	9	4
88	R:R:S196	R:R:Y149	3.82	No	No	0	3	4
89	L:L:Y1	R:R:M151	8.38	Yes	No	0	0	7
90	R:R:F152	R:R:F156	5.36	Yes	Yes	7	7	6
91	R:R:F152	R:R:I198	7.54	Yes	No	0	7	4
92	R:R:F152	R:R:V236	6.55	Yes	No	0	7	5
93	R:R:F152	R:R:F239	3.22	Yes	No	7	7	4
94	R:R:A240	R:R:F152	4.16	No	Yes	0	6	7
95	R:R:T153	R:R:W192	16.98	No	Yes	0	7	9
96	R:R:S195	R:R:T153	4.8	No	No	0	8	7
97	R:R:F156	R:R:I155	3.77	Yes	No	0	6	8
98	R:R:I155	R:R:P244	3.39	No	Yes	0	8	9
99	R:R:I155	R:R:W293	5.87	No	Yes	0	8	8
100	R:R:F156	R:R:N191	3.62	Yes	No	0	6	7
101	R:R:F156	R:R:L194	3.65	Yes	No	0	6	4
102	R:R:F156	R:R:S195	6.61	Yes	No	0	6	8
103	R:R:F156	R:R:F239	4.29	Yes	No	7	6	4
104	R:R:L158	R:R:Y336	3.52	No	Yes	0	8	9
105	R:R:C159	R:R:I247	3.27	No	No	0	7	7
106	R:R:T160	R:R:V187	4.76	No	No	5	7	5
107	R:R:N191	R:R:T160	7.31	No	No	0	7	7
108	R:R:M161	R:R:R165	4.96	No	No	0	8	9
109	R:R:M161	R:R:Y336	7.18	No	Yes	0	8	9
110	R:R:I248	R:R:S162	6.19	No	No	0	8	9
111	R:R:C251	R:R:S162	5.16	No	No	0	7	9
112	R:R:S162	R:R:Y252	15.26	No	Yes	0	9	9
113	R:R:C251	R:R:V163	3.42	No	No	0	7	6
114	R:R:D164	R:R:R179	17.87	No	No	0	8	6
115	R:R:R165	R:R:Y252	5.14	No	Yes	0	9	9
116	R:R:C170	R:R:Y166	8.06	No	Yes	3	7	8
117	R:R:H171	R:R:Y166	6.53	No	Yes	3	6	8
118	R:R:C251	R:R:Y166	4.03	No	Yes	0	7	8
119	R:R:L254	R:R:Y166	7.03	No	Yes	3	4	8
120	R:R:A168	R:R:R179	5.53	No	No	0	8	6
121	R:R:M255	R:R:V169	7.61	No	No	0	8	8
122	R:R:C170	R:R:H171	4.42	No	No	3	7	6
123	R:R:C170	R:R:L254	3.17	No	No	3	7	4
124	R:R:F178	R:R:K174	11.17	No	No	0	4	4
125	R:R:D177	R:R:F178	4.78	No	No	0	4	4
126	R:R:P181	R:R:T180	3.5	No	No	0	1	7
127	R:R:K185	R:R:N188	8.39	No	No	0	2	7
128	R:R:K185	R:R:V189	6.07	No	No	0	2	4
129	R:R:N188	R:R:W192	7.91	No	Yes	6	7	9
130	R:R:G199	R:R:V202	3.68	No	No	0	7	5
131	R:R:L200	R:R:M203	4.24	No	No	0	3	4
132	R:R:L232	R:R:V202	4.47	No	No	0	5	5
133	R:R:F204	R:R:M203	3.73	No	No	0	5	4
134	R:R:M205	R:R:W228	3.49	No	Yes	0	4	3
135	R:R:A206	R:R:L219	3.15	No	No	0	4	5
136	R:R:T207	R:R:T220	6.28	No	No	0	5	4
137	R:R:I215	R:R:Y210	10.88	No	No	0	4	1
138	R:R:R211	R:R:S214	9.22	No	No	0	3	2
139	R:R:D216	R:R:R211	17.87	No	No	0	4	3
140	L:L:?4	R:R:C217	4.12	Yes	Yes	2	0	9
141	R:R:E229	R:R:F221	26.82	No	Yes	0	4	5
142	R:R:N230	R:R:Y227	3.49	No	No	0	3	3
143	R:R:L231	R:R:W228	4.56	No	Yes	0	4	3
144	R:R:K233	R:R:N230	4.2	Yes	No	0	4	3
145	R:R:A304	R:R:K233	3.21	No	Yes	0	4	4
146	L:L:Y1	R:R:V236	7.57	Yes	No	0	0	5
147	R:R:F237	R:R:F241	3.22	Yes	No	1	5	8
148	R:R:F237	R:R:I242	7.54	Yes	No	0	5	5
149	R:R:F237	R:R:H297	4.53	Yes	Yes	1	5	8
150	R:R:F237	R:R:I301	11.3	Yes	No	0	5	6
151	R:R:F241	R:R:V245	3.93	No	No	0	8	6
152	R:R:F241	R:R:H297	11.31	No	Yes	1	8	8
153	R:R:I242	R:R:L246	4.28	No	No	0	5	3
154	R:R:F289	R:R:P244	5.78	Yes	Yes	0	9	9
155	R:R:I290	R:R:V245	4.61	No	No	0	5	6
156	R:R:F289	R:R:I248	6.28	Yes	No	0	9	8
157	R:R:M255	R:R:Y252	4.79	No	Yes	0	8	9
158	R:R:V282	R:R:Y252	3.79	No	Yes	0	7	9
159	R:R:I256	R:R:V282	4.61	No	No	0	5	7
160	R:R:K271	R:R:M264	4.32	No	No	0	4	5
161	R:R:L265	R:R:L275	9.69	No	No	0	3	6
162	R:R:G267	R:R:S266	3.71	No	No	0	3	5
163	R:R:K271	R:R:S268	12.24	No	No	0	4	4
164	R:R:K269	R:R:R273	4.95	No	No	0	1	4
165	R:R:E270	R:R:N274	9.2	No	No	0	2	5
166	R:R:R276	R:R:R280	4.26	No	No	0	5	6
167	R:R:E341	R:R:R277	5.82	No	No	0	4	7
168	R:R:D340	R:R:M281	4.16	No	No	0	8	8
169	R:R:L335	R:R:V285	7.45	Yes	No	1	8	8
170	R:R:V285	R:R:Y336	6.31	No	Yes	1	8	9
171	R:R:F289	R:R:W293	7.02	Yes	Yes	1	9	8
172	R:R:F289	R:R:N328	4.83	Yes	Yes	1	9	9
173	R:R:C292	R:R:T327	3.38	No	No	0	8	5
174	R:R:C292	R:R:N328	3.15	No	Yes	0	8	9
175	R:R:I296	R:R:W293	3.52	Yes	Yes	1	6	8
176	R:R:H297	R:R:W293	6.35	Yes	Yes	1	8	8
177	R:R:N328	R:R:W293	10.17	Yes	Yes	1	9	8
178	R:R:P295	R:R:T294	5.25	No	No	0	9	5
179	R:R:L324	R:R:P295	11.49	No	No	0	7	9
180	R:R:H297	R:R:I296	3.98	Yes	Yes	1	8	6
181	R:R:C321	R:R:I296	4.91	No	Yes	0	6	6
182	R:R:G325	R:R:I296	3.53	No	Yes	0	7	6
183	L:L:Y1	R:R:I296	3.63	Yes	Yes	0	0	6
184	R:R:K303	R:R:Y299	11.94	No	No	2	4	4
185	R:R:Q314	R:R:Y299	6.76	No	No	0	4	4
186	R:R:W318	R:R:Y299	13.5	Yes	No	2	5	4
187	L:L:Y1	R:R:V300	10.09	Yes	No	0	0	5
188	R:R:K303	R:R:W318	3.48	No	Yes	2	4	5
189	L:L:?5	R:R:K303	5.7	Yes	No	2	0	4
190	R:R:I308	R:R:P309	6.77	Yes	No	0	1	3
191	R:R:I308	R:R:Q314	13.72	Yes	No	0	1	4
192	L:L:?2	R:R:W318	10.43	Yes	Yes	2	0	5
193	L:L:?5	R:R:W318	7.68	Yes	Yes	2	0	5
194	L:L:?2	R:R:I322	5.81	Yes	No	0	0	5
195	R:R:N328	R:R:N332	9.54	Yes	Yes	1	9	9
196	R:R:C330	R:R:L331	3.17	No	No	0	7	7
197	R:R:L335	R:R:N332	4.12	Yes	Yes	1	8	9
198	R:R:F338	R:R:V334	3.93	No	No	0	6	6
199	R:R:L335	R:R:Y336	4.69	Yes	Yes	1	8	9
200	R:R:N342	R:R:R345	3.62	No	No	0	6	4
201	L:L:?2	L:L:Y1	11.92	Yes	Yes	0	0	0
202	L:L:?2	L:L:G3	6.96	Yes	No	2	0	0
203	L:L:?2	L:L:?4	4.87	Yes	Yes	2	0	0
204	L:L:?2	L:L:?5	7.59	Yes	Yes	2	0	0
205	L:L:?4	L:L:G3	5.92	Yes	No	2	0	0
206	L:L:?4	L:L:?5	20.99	Yes	Yes	2	0	0
207	R:R:A115	R:R:N86	3.13	No	No	0	7	9
208	R:R:I193	R:R:S196	3.1	No	No	0	4	3
209	R:R:I71	R:R:V316	3.07	No	No	0	4	1
210	R:R:M72	R:R:S125	3.07	No	No	0	5	6
211	R:R:I77	R:R:V81	3.07	No	No	0	5	5
212	R:R:I167	R:R:V163	3.07	No	No	0	5	6
213	R:R:I107	R:R:T103	3.04	No	No	0	8	8
214	R:R:I215	R:R:T132	3.04	No	No	0	4	5
215	R:R:K233	R:R:V300	3.04	Yes	No	0	4	5
216	R:R:I256	R:R:T279	3.04	No	No	0	5	6
217	R:R:I290	R:R:T294	3.04	No	No	0	5	5
218	R:R:F221	R:R:W228	3.01	Yes	Yes	0	5	3
219	R:R:L121	R:R:V78	2.98	No	No	0	7	7
220	R:R:L259	R:R:V169	2.98	No	No	0	8	8
221	R:R:L335	R:R:V288	2.98	Yes	No	0	8	6
222	R:R:L331	R:R:T327	2.95	No	No	0	7	5
223	R:R:I107	R:R:I93	2.94	No	Yes	0	8	7
224	R:R:I238	R:R:I242	2.94	No	No	0	4	5
225	R:R:I298	R:R:I302	2.94	No	No	0	6	5
226	R:R:I302	R:R:I306	2.94	No	No	0	5	3
227	R:R:I306	R:R:I308	2.94	No	Yes	0	3	1
228	R:R:I105	R:R:K185	2.91	No	No	0	6	2
229	R:R:I306	R:R:L305	2.85	No	No	0	3	5
230	R:R:L265	R:R:M264	2.83	No	No	0	3	5
231	R:R:D272	R:R:L275	2.71	No	No	0	3	6
232	R:R:P224	R:R:W228	2.7	No	Yes	0	1	3
233	R:R:A68	R:R:Y128	2.67	No	Yes	0	4	5
234	R:R:A323	R:R:Y75	2.67	No	Yes	0	4	7
235	R:R:R258	R:R:V169	2.62	No	No	0	5	8
236	R:R:R258	R:R:V262	2.62	No	No	0	5	6
237	R:R:F221	R:R:T220	2.59	Yes	No	0	5	4
238	R:R:F313	R:R:T311	2.59	No	No	0	2	1
239	R:R:F313	R:R:T312	2.59	No	No	0	2	4
240	R:R:S125	R:R:Y75	2.54	No	Yes	0	6	7
241	R:R:V286	R:R:Y252	2.52	No	Yes	0	8	9
242	R:R:F178	R:R:I167	2.51	No	No	0	4	5
243	R:R:I186	R:R:R182	2.51	No	No	0	3	3
244	R:R:M281	R:R:R165	2.48	No	No	0	8	9
245	R:R:F338	R:R:L88	2.44	No	No	0	6	6
246	R:R:F320	R:R:L324	2.44	No	No	0	5	7
247	R:R:T225	R:R:W226	2.43	No	No	0	3	2
248	R:R:L283	R:R:R280	2.43	No	No	0	4	6
249	R:R:I71	R:R:Y128	2.42	No	Yes	0	4	5
250	R:R:N274	R:R:R277	2.41	No	No	0	5	7
251	R:R:R95	R:R:Y96	2.06	Yes	No	0	4	5
252	R:R:C159	R:R:P244	1.88	No	Yes	0	7	9
253	R:R:G267	R:R:S268	1.86	No	No	0	3	4
254	R:R:A102	R:R:A184	1.79	No	No	0	6	7
255	R:R:C79	R:R:S76	1.72	No	No	0	6	4
256	R:R:G85	R:R:L88	1.71	No	No	0	7	6
257	R:R:M243	R:R:P244	1.68	No	Yes	0	5	9
258	R:R:L200	R:R:P201	1.64	No	No	0	3	7
259	R:R:G213	R:R:Q212	1.64	No	No	0	3	5
260	R:R:A175	R:R:I167	1.62	No	No	0	6	5
261	R:R:S119	R:R:T120	1.6	No	No	0	5	6
262	R:R:T249	R:R:V250	1.59	No	No	0	4	4
263	R:R:T249	R:R:V286	1.59	No	No	0	4	8
264	R:R:A197	R:R:L194	1.58	No	No	0	4	4
265	R:R:A117	R:R:N150	1.56	No	No	0	7	8
266	R:R:H171	R:R:P172	1.53	No	No	0	6	7
267	R:R:M205	R:R:S222	1.53	No	No	0	4	6
268	R:R:M65	R:R:V66	1.52	No	No	0	2	2
269	R:R:I69	R:R:T70	1.52	No	No	0	4	4
270	R:R:M264	R:R:V262	1.52	No	No	0	5	6
271	R:R:F84	R:R:G85	1.51	No	No	0	4	7
272	R:R:L200	R:R:S196	1.5	No	No	0	3	3
273	R:R:L335	R:R:V284	1.49	Yes	No	0	8	6
274	R:R:I93	R:R:M99	1.46	Yes	No	0	7	7
275	R:R:I105	R:R:M99	1.46	No	No	0	6	7
276	R:R:N183	R:R:T180	1.46	No	No	0	4	7
277	R:R:D216	R:R:T218	1.45	No	No	0	4	3
278	R:R:I256	R:R:K260	1.45	No	No	0	5	4
279	R:R:Q314	R:R:S317	1.44	No	No	0	4	5
280	R:R:I138	R:R:L139	1.43	No	No	0	2	6
281	R:R:I278	R:R:L259	1.43	No	No	0	7	8
282	R:R:I186	R:R:N183	1.42	No	No	0	3	4
283	R:R:I234	R:R:N230	1.42	No	No	0	4	3
284	R:R:C235	R:R:F239	1.4	No	No	0	3	4
285	R:R:K271	R:R:N274	1.4	No	No	0	4	5
286	R:R:H223	R:R:T225	1.37	No	No	0	4	3
287	R:R:E310	R:R:I308	1.37	No	Yes	0	1	1
288	R:R:E229	R:R:K233	1.35	No	Yes	0	4	4
289	R:R:R258	R:R:S261	1.32	No	No	0	5	4
290	R:R:R276	R:R:T279	1.29	No	No	0	5	6
291	R:R:T67	R:R:Y128	1.25	No	Yes	0	3	5
292	R:R:F343	R:R:K344	1.24	No	No	0	9	8
293	R:R:L112	R:R:W192	1.14	No	Yes	0	6	9
294	R:R:F338	R:R:F343	1.07	No	No	0	6	9
295	R:R:F221	R:R:W226	1	Yes	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y75	4.048	5	0	7
2	R:R:I93	4.84	5	4	7
3	R:R:R95	5.7025	4	0	4
4	R:R:Y106	6.38	4	5	7
5	R:R:L110	7.98	4	1	9
6	R:R:D114	7.83	5	1	9
7	R:R:Y128	4.944	5	0	5
8	R:R:W133	10.9217	6	2	8
9	R:R:F135	10.235	4	0	7
10	R:R:C140	5.115	4	2	9
11	R:R:I144	6.0375	4	2	5
12	R:R:F152	5.366	5	7	7
13	R:R:F156	4.55	6	7	6
14	R:R:Y166	6.4125	4	3	8
15	R:R:W192	10.04	5	6	9
16	R:R:C217	8.89	4	2	9
17	R:R:F221	8.355	4	0	5
18	R:R:W228	3.44	4	0	3
19	R:R:K233	2.95	4	0	4
20	R:R:F237	6.6475	4	1	5
21	R:R:P244	3.1825	4	0	9
22	R:R:Y252	6.3	5	0	9
23	R:R:F289	5.9775	4	1	9
24	R:R:W293	6.586	5	1	8
25	R:R:I296	3.914	5	1	6
26	R:R:H297	6.5425	4	1	8
27	R:R:I308	6.2	4	0	1
28	R:R:W318	8.7725	4	2	5
29	R:R:N328	6.9225	4	1	9
30	R:R:N332	7.8425	4	1	9
31	R:R:L335	4.146	5	1	8
32	R:R:Y336	5.425	4	1	9
33	L:L:Y1	8.09	6	0	0
34	L:L:?2	7.93	6	2	0
35	L:L:?4	7.36	9	2	0
36	L:L:?5	10.49	4	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S125	R:R:Y75	12.1873	2.54	No	Yes	0	6	7
2	R:R:Q124	R:R:Y75	11.7704	4.51	No	Yes	0	6	7
3	R:R:H319	R:R:Y75	16.7731	3.27	No	Yes	0	4	7
4	R:R:I322	R:R:Y75	21.7846	7.25	No	Yes	0	5	7
5	R:R:L121	R:R:Y326	14.4935	11.72	No	No	0	7	7
6	R:R:D147	R:R:Y326	17.3408	5.75	No	No	0	6	7
7	L:L:?4	R:R:Q124	31.7101	6.91	Yes	No	0	0	6
8	R:R:G85	R:R:P333	23.053	4.06	No	No	0	7	9
9	R:R:N86	R:R:P333	34.1582	11.4	No	No	0	9	9
10	R:R:D114	R:R:N86	39.6044	6.73	Yes	No	0	9	9
11	R:R:D114	R:R:N332	37.1918	6.73	Yes	Yes	1	9	9
12	R:R:N328	R:R:N332	56.1203	9.54	Yes	Yes	1	9	9
13	R:R:N328	R:R:W293	47.1705	10.17	Yes	Yes	1	9	8
14	R:R:I296	R:R:W293	87.9723	3.52	Yes	Yes	1	6	8
15	L:L:Y1	R:R:I296	98.0043	3.63	Yes	Yes	0	0	6
16	L:L:?2	L:L:Y1	100	11.92	Yes	Yes	0	0	0
17	L:L:?2	R:R:I322	23.5852	5.81	Yes	No	0	0	5
18	R:R:L331	R:R:T327	11.6995	2.95	No	No	0	7	5
19	R:R:C292	R:R:T327	13.9879	3.38	No	No	0	8	5
20	R:R:C292	R:R:N328	16.2586	3.15	No	Yes	0	8	9
21	R:R:F108	R:R:I93	35.3113	5.02	No	Yes	0	6	7
22	R:R:I93	R:R:M99	42.1767	1.46	Yes	No	0	7	7
23	R:R:I105	R:R:M99	44.2877	1.46	No	No	0	6	7
24	R:R:I105	R:R:K185	46.3988	2.91	No	No	0	6	2
25	R:R:K185	R:R:N188	50.6741	8.39	No	No	0	2	7
26	R:R:N188	R:R:W192	31.7279	7.91	No	Yes	6	7	9
27	R:R:W192	R:R:Y149	35.3025	10.61	Yes	No	0	9	4
28	R:R:N150	R:R:Y149	27.6388	3.49	No	No	0	8	4
29	R:R:L116	R:R:N150	26.3793	10.98	No	No	0	7	8
30	R:R:I146	R:R:L116	26.1398	4.28	No	No	0	5	7
31	R:R:I146	R:R:T120	27.1155	4.56	No	No	0	5	6
32	R:R:Q124	R:R:T120	30.0337	4.25	No	No	0	6	6
33	R:R:F108	R:R:V94	22.716	3.93	No	No	0	6	3
34	R:R:R95	R:R:V94	19.5228	6.54	Yes	No	0	4	3
35	L:L:Y1	R:R:V236	41.0946	7.57	Yes	No	0	0	5
36	R:R:F152	R:R:V236	40.0124	6.55	Yes	No	0	7	5
37	R:R:F152	R:R:F156	40.9349	5.36	Yes	Yes	7	7	6
38	R:R:F156	R:R:N191	38.5489	3.62	Yes	No	0	6	7
39	R:R:N191	R:R:T160	36.2693	7.31	No	No	0	7	7
40	R:R:T160	R:R:Y106	31.4618	6.24	No	Yes	5	7	7
41	R:R:D164	R:R:Y106	24.7649	11.49	No	Yes	0	8	7
42	R:R:D164	R:R:R179	22.4588	17.87	No	No	0	8	6
43	R:R:R179	R:R:T103	18.148	3.88	No	No	0	6	8
44	R:R:N109	R:R:W192	12.8437	13.56	No	Yes	6	9	9
45	R:R:N109	R:R:T157	33.7591	13.16	No	No	0	9	7
46	R:R:L110	R:R:N332	17.2343	10.98	Yes	Yes	1	9	9
47	R:R:L110	R:R:T157	34.8767	5.9	Yes	No	0	9	7
48	R:R:L110	R:R:L158	20.1969	5.54	Yes	No	0	9	8
49	R:R:T153	R:R:W192	29.1201	16.98	No	Yes	0	7	9
50	R:R:S195	R:R:T153	31.7456	4.8	No	No	0	8	7
51	R:R:F156	R:R:S195	33.5462	6.61	Yes	No	0	6	8
52	R:R:F135	R:R:W133	31.2755	19.04	Yes	Yes	0	7	8
53	L:L:?4	R:R:W133	43.0548	4.93	Yes	Yes	2	0	8
54	R:R:F135	R:R:V126	24.3747	5.24	Yes	No	0	7	5
55	R:R:P134	R:R:V126	22.2547	7.07	No	No	0	4	5
56	R:R:H319	R:R:Y128	14.3871	10.89	No	Yes	0	4	5
57	R:R:P134	R:R:T132	17.4384	6.99	No	No	0	4	5
58	R:R:S214	R:R:T132	10.0674	4.8	No	No	0	2	5
59	R:R:C140	R:R:W133	10.1118	6.53	Yes	Yes	2	9	8
60	L:L:?4	R:R:I144	16.3385	11.11	Yes	Yes	2	0	5
61	L:L:?4	R:R:C217	11.3624	4.12	Yes	Yes	2	0	9
62	R:R:C140	R:R:T208	21.0396	3.38	Yes	No	0	9	5
63	R:R:N137	R:R:T208	14.0412	10.24	No	No	0	1	5
64	R:R:S196	R:R:Y149	19.5494	3.82	No	No	0	3	4
65	R:R:L200	R:R:S196	14.05	1.5	No	No	0	3	3
66	R:R:D147	R:R:Y148	14.5911	3.45	No	No	0	6	4
67	L:L:Y1	R:R:Y148	20.1703	6.95	Yes	No	0	0	4
68	R:R:I155	R:R:W293	33.7768	5.87	No	Yes	0	8	8
69	R:R:I155	R:R:P244	18.352	3.39	No	Yes	0	8	9
70	R:R:F289	R:R:W293	64.8749	7.02	Yes	Yes	1	9	8
71	R:R:F289	R:R:P244	18.6358	5.78	Yes	Yes	0	9	9
72	R:R:L335	R:R:N332	16.3562	4.12	Yes	Yes	1	8	9
73	R:R:M161	R:R:Y336	26.7873	7.18	No	Yes	0	8	9
74	R:R:F289	R:R:I248	88.469	6.28	Yes	No	0	9	8
75	R:R:I248	R:R:S162	86.5265	6.19	No	No	0	8	9
76	R:R:S162	R:R:Y252	60.5819	15.26	No	Yes	0	9	9
77	R:R:R165	R:R:Y252	27.967	5.14	No	Yes	0	9	9
78	R:R:C251	R:R:S162	32.5616	5.16	No	No	0	7	9
79	R:R:C251	R:R:V163	16.5957	3.42	No	No	0	7	6
80	R:R:C251	R:R:Y166	13.8726	4.03	No	Yes	0	7	8
81	R:R:M255	R:R:Y252	51.1442	4.79	No	Yes	0	8	9
82	R:R:M255	R:R:V169	48.5631	7.61	No	No	0	8	8
83	R:R:I167	R:R:V163	13.8726	3.07	No	No	0	5	6
84	L:L:Y1	R:R:V300	42.5936	10.09	Yes	No	0	0	5
85	R:R:K233	R:R:V300	40.5003	3.04	Yes	No	0	4	5
86	R:R:E229	R:R:K233	29.0491	1.35	No	Yes	0	4	4
87	R:R:E229	R:R:F221	26.9203	26.82	No	Yes	0	4	5
88	R:R:F221	R:R:W228	12.4978	3.01	Yes	Yes	0	5	3
89	R:R:F237	R:R:H297	13.2517	4.53	Yes	Yes	1	5	8
90	R:R:H297	R:R:I296	12.4446	3.98	Yes	Yes	1	8	6
91	R:R:F241	R:R:H297	18.556	11.31	No	Yes	1	8	8
92	R:R:F241	R:R:V245	16.2232	3.93	No	No	0	8	6
93	R:R:I290	R:R:V245	13.5622	4.61	No	No	0	5	6
94	R:R:V282	R:R:Y252	19.5494	3.79	No	Yes	0	7	9
95	R:R:I256	R:R:V282	17.0037	4.61	No	No	0	5	7
96	R:R:R258	R:R:V169	41.1478	2.62	No	No	0	5	8
97	R:R:R258	R:R:V262	35.879	2.62	No	No	0	5	6
98	R:R:M264	R:R:V262	33.2092	1.52	No	No	0	5	6
99	R:R:K271	R:R:M264	22.3523	4.32	No	No	0	4	5
100	R:R:K271	R:R:N274	11.2116	1.4	No	No	0	4	5
101	R:R:I256	R:R:T279	11.4068	3.04	No	No	0	5	6
102	R:R:I290	R:R:T294	10.8834	3.04	No	No	0	5	5
103	L:L:?4	L:L:?5	11.7261	20.99	Yes	Yes	2	0	0
104	L:L:?2	R:R:W318	27.896	10.43	Yes	Yes	2	0	5
105	R:R:W318	R:R:Y299	28.854	13.5	Yes	No	2	5	4
106	R:R:Q314	R:R:Y299	30.7433	6.76	No	No	0	4	4
107	R:R:I308	R:R:Q314	24.0376	13.72	Yes	No	0	1	4
108	R:R:F338	R:R:L88	11.664	2.44	No	No	0	6	6
109	R:R:G85	R:R:L88	14.5379	1.71	No	No	0	7	6
110	R:R:I107	R:R:T103	16.6046	3.04	No	No	0	8	8
111	R:R:I107	R:R:I93	15.6378	2.94	No	Yes	0	8	7
112	R:R:I306	R:R:I308	14.0057	2.94	No	Yes	0	3	1
113	L:L:?2	L:L:?4	57.2024	4.87	Yes	Yes	2	0	0
114	R:R:D114	R:R:L110	13.0832	9.5	Yes	Yes	1	9	9
115	R:R:N109	R:R:N188	21.0839	17.71	No	No	6	9	7
116	R:R:F156	R:R:I155	42.2743	3.77	Yes	No	0	6	8
117	R:R:F289	R:R:N328	17.8109	4.83	Yes	Yes	1	9	9
118	R:R:L158	R:R:Y336	18.7334	3.52	No	Yes	0	8	9
119	R:R:M161	R:R:R165	25.2617	4.96	No	No	0	8	9
120	R:R:H297	R:R:W293	21.8999	6.35	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q124	R:R:Y75	4.51	0	No	Yes	6	7	1	2
R:R:I322	R:R:Y75	7.25	0	No	Yes	5	7	1	2
R:R:Q124	R:R:T120	4.25	0	No	No	6	6	1	2
R:R:F123	R:R:F135	11.79	0	No	Yes	6	7	2	2
R:R:F123	R:R:V143	5.24	0	No	No	6	5	2	1
L:L:?4	R:R:Q124	6.91	2	Yes	No	0	6	0	1
R:R:N127	R:R:W133	6.78	0	No	Yes	6	8	2	1
R:R:F135	R:R:W133	19.04	0	Yes	Yes	7	8	2	1
R:R:C140	R:R:W133	6.53	2	Yes	Yes	9	8	2	1
R:R:V143	R:R:W133	7.36	2	No	Yes	5	8	1	1
R:R:C217	R:R:W133	20.89	2	Yes	Yes	9	8	1	1
L:L:?4	R:R:W133	4.93	2	Yes	Yes	0	8	0	1
R:R:C140	R:R:I144	3.27	2	Yes	Yes	9	5	2	1
R:R:C140	R:R:C217	7.28	2	Yes	Yes	9	9	2	1
L:L:?4	R:R:V143	3.87	2	Yes	No	0	5	0	1
R:R:A206	R:R:I144	6.5	0	No	Yes	4	5	2	1
R:R:C217	R:R:I144	3.27	2	Yes	Yes	9	5	1	1
L:L:?4	R:R:I144	11.11	2	Yes	Yes	0	5	0	1
R:R:D147	R:R:Y148	3.45	0	No	No	6	4	1	1
R:R:D147	R:R:Y326	5.75	0	No	No	6	7	1	2
L:L:?4	R:R:D147	3.52	2	Yes	No	0	6	0	1
R:R:V202	R:R:Y148	12.62	0	No	No	5	4	2	1
L:L:Y1	R:R:Y148	6.95	0	Yes	No	0	4	0	1
L:L:Y1	R:R:M151	8.38	0	Yes	No	0	7	0	1
R:R:F152	R:R:V236	6.55	7	Yes	No	7	5	2	1
L:L:?4	R:R:C217	4.12	2	Yes	Yes	0	9	0	1
L:L:Y1	R:R:V236	7.57	0	Yes	No	0	5	0	1
R:R:I296	R:R:W293	3.52	1	Yes	Yes	6	8	1	2
R:R:H297	R:R:W293	6.35	1	Yes	Yes	8	8	2	2
R:R:H297	R:R:I296	3.98	1	Yes	Yes	8	6	2	1
R:R:C321	R:R:I296	4.91	0	No	Yes	6	6	2	1
R:R:G325	R:R:I296	3.53	0	No	Yes	7	6	2	1
L:L:Y1	R:R:I296	3.63	0	Yes	Yes	0	6	0	1
R:R:K303	R:R:Y299	11.94	2	No	No	4	4	1	2
R:R:W318	R:R:Y299	13.5	2	Yes	No	5	4	1	2
L:L:Y1	R:R:V300	10.09	0	Yes	No	0	5	0	1
R:R:K303	R:R:W318	3.48	2	No	Yes	4	5	1	1
L:L:?5	R:R:K303	5.7	2	Yes	No	0	4	0	1
L:L:?2	R:R:W318	10.43	2	Yes	Yes	0	5	0	1
L:L:?5	R:R:W318	7.68	2	Yes	Yes	0	5	0	1
L:L:?2	R:R:I322	5.81	2	Yes	No	0	5	0	1
R:R:K233	R:R:V300	3.04	0	Yes	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6DDF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	270
Number of Links	295
Number of Hubs	36
Number of Links mediated by Hubs	135
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	121
Number Of Links MetaPath	120
Number of Shortest Paths	41029
Length Of Smallest Path	3
Average Path Length	12.3448
Length of Longest Path	27
Minimum Path Strength	1.155
Average Path Strength	6.45349
Maximum Path Strength	19.965
Minimum Path Correlation	0.7
Average Path Correlation	0.923759
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	54.1527
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8813
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled opioid receptor activity • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • behavior • locomotory behavior • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • metabolic process • regulation of nitric oxide metabolic process • regulation of metabolic process • transmission of nerve impulse • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • neurogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • dendrite • dendritic tree • GABA-ergic synapse • endosome • intracellular vesicle • cytoplasmic vesicle • axon
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DAL
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DAL
Name	D-Alanine
Synonyms	(R)-alanine
Identifier
Formula	C3 H7 N O2
Molecular Weight	89.093
SMILES
PubChem	71080
Formal Charge	0
Total Atoms	13
Total Chiral Atoms	1
Total Bonds	12
Total Aromatic Bonds	0


Code	MEA
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	MEA
Name	N-METHYLPHENYLALANINE
Synonyms
Identifier
Formula	C10 H13 N O2
Molecular Weight	179.216
SMILES
PubChem	6951134
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


Code	ETA
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	ETA
Name	Ethanolamine
Synonyms	Ethanolamine hydrochloride Ethanolamine acetate Ethanolamine
Identifier
Formula	C2 H7 N O
Molecular Weight	61.083
SMILES
PubChem	700
Formal Charge	0
Total Atoms	11
Total Chiral Atoms	0
Total Bonds	10
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>6DDF_nogp_Chain_R M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

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