psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P13	R:R:S66	3.56	No	No	0	0	7
2	R:R:T314	R:R:T69	3.14	No	No	2	1	4
3	L:L:T12	R:R:A70	3.36	No	No	0	0	4
4	R:R:I73	R:R:Y130	8.46	No	No	2	6	5
5	R:R:H321	R:R:I73	6.63	Yes	No	2	4	6
6	R:R:M74	R:R:S127	4.6	No	No	0	5	6
7	R:R:L131	R:R:M74	11.31	No	No	0	4	5
8	R:R:A325	R:R:L76	3.15	No	No	0	6	5
9	R:R:L123	R:R:Y77	5.86	Yes	No	0	7	7
10	R:R:H321	R:R:Y77	9.8	Yes	No	0	4	7
11	R:R:I324	R:R:Y77	7.25	No	No	0	5	7
12	R:R:C81	R:R:L85	3.17	No	No	0	6	6
13	R:R:C81	R:R:L123	3.17	No	Yes	0	6	7
14	R:R:C81	R:R:P124	3.77	No	No	0	6	8
15	R:R:C332	R:R:V83	3.42	No	No	0	8	5
16	R:R:C332	R:R:G84	3.92	No	No	0	8	8
17	R:R:F89	R:R:L85	3.65	No	No	0	4	6
18	R:R:L85	R:R:T120	5.9	No	No	0	6	5
19	R:R:G87	R:R:P335	4.06	No	No	0	8	9
20	R:R:D116	R:R:N88	6.73	Yes	No	0	9	9
21	R:R:A117	R:R:N88	4.69	No	No	0	7	9
22	R:R:N88	R:R:P335	4.89	No	No	0	9	9
23	R:R:F340	R:R:L90	3.65	No	No	0	6	6
24	R:R:I95	R:R:V91	3.07	No	Yes	0	7	9
25	R:R:A113	R:R:V91	3.39	No	Yes	0	9	9
26	R:R:P335	R:R:V91	3.53	No	Yes	0	9	9
27	R:R:A339	R:R:V91	3.39	No	Yes	0	6	9
28	R:R:R97	R:R:Y93	12.35	No	No	0	5	4
29	R:R:F110	R:R:I95	5.02	No	No	0	6	7
30	R:R:F345	R:R:I95	6.28	Yes	No	0	8	7
31	R:R:F110	R:R:V96	3.93	No	No	0	6	3
32	R:R:R97	R:R:Y98	9.26	No	No	0	5	4
33	R:R:F352	R:R:Y98	17.54	No	No	0	7	4
34	R:R:N106	R:R:T99	5.85	No	Yes	6	8	6
35	R:R:F345	R:R:T99	5.19	Yes	Yes	6	8	6
36	R:R:F110	R:R:M101	7.46	No	No	0	6	7
37	R:R:N106	R:R:T103	4.39	No	No	0	8	7
38	R:R:F345	R:R:N106	7.25	Yes	No	6	8	8
39	R:R:T162	R:R:Y108	6.24	No	Yes	0	7	7
40	R:R:M163	R:R:Y108	3.59	No	Yes	0	9	7
41	R:R:D166	R:R:Y108	5.75	No	Yes	0	8	7
42	R:R:A186	R:R:Y108	5.34	No	Yes	0	7	7
43	R:R:N190	R:R:Y108	11.63	No	Yes	0	7	7
44	R:R:F345	R:R:I109	6.28	Yes	No	0	8	8
45	R:R:N111	R:R:N190	9.54	No	No	0	9	7
46	R:R:N111	R:R:W194	5.65	No	Yes	0	9	9
47	R:R:L112	R:R:T159	5.9	No	No	0	9	8
48	R:R:L112	R:R:L160	5.54	No	No	0	9	8
49	R:R:L114	R:R:W194	4.56	No	Yes	0	7	9
50	R:R:A115	R:R:T155	3.36	No	Yes	0	8	7
51	R:R:D116	R:R:S156	5.89	Yes	No	0	9	9
52	R:R:D116	R:R:S331	10.31	Yes	No	0	9	9
53	R:R:D116	R:R:N334	9.42	Yes	Yes	0	9	9
54	R:R:L118	R:R:N152	13.73	No	No	0	7	8
55	R:R:S331	R:R:T120	3.2	No	No	0	9	5
56	R:R:D149	R:R:T122	5.78	No	No	0	5	6
57	R:R:L123	R:R:Y328	4.69	Yes	No	0	7	7
58	R:R:F125	R:R:F137	6.43	No	Yes	0	6	6
59	R:R:D149	R:R:Q126	3.92	No	No	7	5	6
60	R:R:Q126	R:R:Y328	7.89	No	No	7	6	7
61	L:L:F4	R:R:Q126	8.2	No	No	0	0	6
62	R:R:F137	R:R:V128	5.24	Yes	No	0	6	3
63	R:R:N129	R:R:W135	7.91	No	Yes	0	4	8
64	R:R:H321	R:R:Y130	11.98	Yes	No	2	4	5
65	L:L:V15	R:R:L131	4.47	Yes	No	0	0	4
66	L:L:K9	R:R:G133	5.23	No	No	0	0	2
67	R:R:S216	R:R:T134	3.2	No	No	0	1	5
68	R:R:I217	R:R:T134	4.56	No	No	0	4	5
69	R:R:F137	R:R:W135	20.04	Yes	Yes	0	6	8
70	R:R:C142	R:R:W135	6.53	Yes	Yes	4	9	8
71	R:R:C219	R:R:W135	18.28	No	Yes	4	9	8
72	R:R:F137	R:R:P136	4.33	Yes	No	0	6	3
73	R:R:F137	R:R:L141	6.09	Yes	No	0	6	5
74	R:R:T139	R:R:T210	9.42	No	No	0	3	4
75	R:R:C142	R:R:I146	3.27	Yes	Yes	4	9	4
76	R:R:C142	R:R:T210	3.38	Yes	No	0	9	4
77	R:R:C142	R:R:C219	7.28	Yes	No	4	9	9
78	R:R:A208	R:R:I146	3.25	No	Yes	0	5	4
79	R:R:C219	R:R:I146	3.27	No	Yes	4	9	4
80	L:L:F4	R:R:I146	10.05	No	Yes	0	0	4
81	R:R:M205	R:R:S147	9.2	No	No	0	5	6
82	R:R:I148	R:R:N152	4.25	No	No	0	5	8
83	R:R:D149	R:R:Y328	8.05	No	No	7	5	7
84	R:R:V204	R:R:Y150	7.57	No	No	0	5	4
85	L:L:Y1	R:R:Y150	7.94	Yes	No	0	0	4
86	R:R:N152	R:R:Y151	3.49	No	Yes	0	8	5
87	R:R:T155	R:R:Y151	6.24	Yes	Yes	3	7	5
88	R:R:W194	R:R:Y151	9.65	Yes	Yes	3	9	5
89	R:R:S197	R:R:Y151	3.82	No	Yes	3	8	5
90	R:R:M153	R:R:W295	4.65	No	Yes	0	7	8
91	L:L:Y1	R:R:M153	5.99	Yes	No	0	0	7
92	R:R:F154	R:R:I200	7.54	No	No	0	6	5
93	R:R:F154	R:R:V238	5.24	No	No	0	6	5
94	R:R:T155	R:R:W194	14.55	Yes	Yes	3	7	9
95	R:R:S197	R:R:T155	6.4	No	Yes	3	8	7
96	R:R:I157	R:R:P246	3.39	No	No	0	7	8
97	R:R:I157	R:R:W295	10.57	No	Yes	0	7	8
98	R:R:L160	R:R:N334	4.12	No	Yes	1	8	9
99	R:R:L160	R:R:Y338	7.03	No	Yes	1	8	9
100	R:R:C161	R:R:P246	3.77	No	No	0	7	8
101	R:R:N193	R:R:T162	7.31	No	No	0	7	7
102	R:R:M163	R:R:Y338	4.79	No	Yes	0	9	9
103	R:R:I250	R:R:S164	4.64	No	No	1	8	9
104	R:R:C253	R:R:S164	3.44	No	No	0	8	9
105	R:R:S164	R:R:Y254	10.17	No	Yes	1	9	9
106	R:R:I169	R:R:V165	3.07	No	No	0	5	6
107	R:R:D166	R:R:F180	4.78	No	No	0	8	3
108	R:R:D166	R:R:R181	8.34	No	No	0	8	7
109	R:R:R167	R:R:Y254	8.23	No	Yes	0	9	9
110	R:R:M257	R:R:R167	4.96	No	No	0	8	9
111	R:R:R167	R:R:Y338	3.09	No	Yes	0	9	9
112	R:R:C172	R:R:Y168	8.06	No	Yes	9	7	8
113	R:R:H173	R:R:Y168	4.36	Yes	Yes	9	6	8
114	R:R:C253	R:R:Y168	9.41	No	Yes	0	8	8
115	R:R:L256	R:R:Y168	7.03	No	Yes	0	5	8
116	R:R:F180	R:R:I169	13.82	No	No	0	3	5
117	R:R:M257	R:R:V171	7.61	No	No	0	8	8
118	R:R:C172	R:R:H173	4.42	No	Yes	9	7	6
119	R:R:F180	R:R:N185	4.83	No	No	0	3	4
120	R:R:I188	R:R:R184	3.76	No	No	0	3	3
121	R:R:I189	R:R:N185	7.08	No	No	0	5	4
122	R:R:I195	R:R:V191	3.07	No	No	0	4	4
123	R:R:L202	R:R:S198	4.5	No	No	0	4	4
124	R:R:F223	R:R:M207	3.73	Yes	No	0	6	5
125	R:R:T209	R:R:T222	6.28	No	No	0	5	4
126	R:R:I217	R:R:T210	4.56	No	No	0	4	4
127	R:R:K211	R:R:T222	9.01	No	No	0	1	4
128	R:R:G215	R:R:Y212	5.79	No	No	0	5	3
129	L:L:E8	R:R:R213	5.82	No	No	0	0	2
130	L:L:E8	R:R:Q214	3.82	No	No	0	0	2
131	R:R:D218	R:R:S216	5.89	No	No	0	4	1
132	L:L:K9	R:R:D218	4.15	No	No	0	0	4
133	R:R:F223	R:R:L221	6.09	Yes	No	0	6	4
134	R:R:E231	R:R:F223	9.33	No	Yes	0	4	6
135	R:R:F223	R:R:L234	3.65	Yes	No	0	6	6
136	R:R:S224	R:R:W230	4.94	No	No	0	3	1
137	R:R:H225	R:R:P226	6.1	No	No	0	2	4
138	R:R:P226	R:R:W228	6.76	No	No	0	4	1
139	R:R:W228	R:R:Y229	5.79	No	No	0	1	1
140	R:R:L233	R:R:Y229	5.86	No	No	0	3	1
141	R:R:E231	R:R:K235	6.75	No	No	0	4	4
142	R:R:A306	R:R:K235	3.21	No	No	0	4	4
143	L:L:Y1	R:R:V238	6.31	Yes	No	0	0	5
144	R:R:F239	R:R:F243	6.43	Yes	Yes	10	6	8
145	R:R:F239	R:R:I244	3.77	Yes	No	10	6	4
146	R:R:F239	R:R:H299	4.53	Yes	No	0	6	7
147	R:R:F239	R:R:I303	7.54	Yes	No	0	6	5
148	R:R:F243	R:R:I244	3.77	Yes	No	10	8	4
149	R:R:F243	R:R:T296	9.08	Yes	Yes	0	8	5
150	R:R:I250	R:R:Y254	3.63	No	Yes	1	8	9
151	R:R:F291	R:R:I250	7.54	Yes	No	1	9	8
152	R:R:V284	R:R:Y254	8.83	No	Yes	0	8	9
153	R:R:V288	R:R:Y254	3.79	No	Yes	0	8	9
154	R:R:I258	R:R:T281	4.56	No	No	0	5	6
155	R:R:I258	R:R:V284	4.61	No	No	0	5	8
156	R:R:L267	R:R:V264	7.45	No	No	0	1	6
157	R:R:L267	R:R:L277	6.92	No	No	0	1	6
158	R:R:K273	R:R:S270	10.71	No	No	0	3	2
159	R:R:E272	R:R:R275	10.47	No	No	0	3	4
160	R:R:N276	R:R:R279	8.44	No	No	0	5	7
161	R:R:L341	R:R:M283	7.07	No	No	0	7	8
162	R:R:L337	R:R:V287	7.45	Yes	No	0	8	8
163	R:R:I292	R:R:V288	3.07	No	No	0	6	8
164	R:R:F291	R:R:W295	7.02	Yes	Yes	1	9	8
165	R:R:F291	R:R:N330	4.83	Yes	Yes	1	9	9
166	R:R:I292	R:R:T296	4.56	No	Yes	0	6	5
167	R:R:C294	R:R:T329	3.38	No	No	0	9	5
168	R:R:C294	R:R:N330	7.87	No	Yes	0	9	9
169	R:R:H299	R:R:W295	7.41	No	Yes	0	7	8
170	R:R:N330	R:R:W295	10.17	Yes	Yes	1	9	8
171	R:R:P297	R:R:T296	3.5	No	Yes	0	9	5
172	R:R:L326	R:R:P297	4.93	No	No	0	8	9
173	R:R:C323	R:R:I298	3.27	No	No	0	6	6
174	R:R:Q316	R:R:Y301	3.38	No	Yes	0	3	5
175	R:R:S319	R:R:Y301	7.63	No	Yes	0	4	5
176	R:R:W320	R:R:Y301	5.79	Yes	Yes	0	4	5
177	R:R:C323	R:R:Y301	4.03	No	Yes	0	6	5
178	L:L:Y1	R:R:V302	3.79	Yes	No	0	0	5
179	R:R:K305	R:R:W320	11.6	No	Yes	0	3	4
180	R:R:I310	R:R:Q316	9.61	No	No	0	4	3
181	R:R:I324	R:R:W320	5.87	No	Yes	5	5	4
182	L:L:G2	R:R:W320	5.63	No	Yes	5	0	4
183	L:L:M5	R:R:W320	4.65	No	Yes	0	0	4
184	L:L:G2	R:R:I324	3.53	No	No	5	0	5
185	R:R:N330	R:R:N334	6.81	Yes	Yes	1	9	9
186	R:R:N334	R:R:Y338	5.81	Yes	Yes	1	9	9
187	R:R:F340	R:R:V336	5.24	No	No	0	6	6
188	R:R:L337	R:R:Y338	5.86	Yes	Yes	0	8	9
189	R:R:D342	R:R:N344	8.08	No	No	0	8	7
190	R:R:D342	R:R:F345	3.58	No	Yes	0	8	8
191	R:R:E343	R:R:K346	12.15	No	No	0	5	8
192	R:R:K346	R:R:R350	8.66	No	No	0	8	5
193	L:L:M5	L:L:Y1	3.59	No	Yes	0	0	0
194	L:L:T12	L:L:V15	3.17	No	Yes	0	0	0
195	L:L:F18	L:L:L14	12.18	No	No	0	0	0
196	R:R:I73	R:R:T69	3.04	No	No	2	6	4
197	R:R:I109	R:R:T105	3.04	No	No	0	8	8
198	R:R:M266	R:R:V264	3.04	No	No	0	4	6
199	R:R:I300	R:R:T296	3.04	No	Yes	0	6	5
200	R:R:F223	R:R:W230	3.01	Yes	No	0	6	1
201	R:R:L118	R:R:S121	3	No	No	0	7	5
202	R:R:K143	R:R:T139	3	No	No	0	6	3
203	R:R:L123	R:R:V80	2.98	Yes	No	0	7	7
204	R:R:L141	R:R:V145	2.98	No	No	0	5	5
205	R:R:L261	R:R:V171	2.98	No	No	0	8	8
206	R:R:L234	R:R:V238	2.98	No	No	0	6	5
207	R:R:L333	R:R:V290	2.98	No	No	0	6	7
208	R:R:L337	R:R:V290	2.98	Yes	No	0	8	7
209	R:R:L277	R:R:T281	2.95	No	No	0	6	6
210	R:R:L285	R:R:T281	2.95	No	No	0	5	6
211	R:R:I144	R:R:I148	2.94	No	No	0	5	5
212	R:R:I236	R:R:I240	2.94	No	No	0	4	5
213	R:R:I300	R:R:I304	2.94	No	No	0	6	5
214	R:R:A242	R:R:H299	2.93	No	No	0	5	7
215	R:R:I71	R:R:M67	2.92	No	No	0	5	2
216	R:R:I107	R:R:K187	2.91	No	No	0	5	2
217	L:L:K19	R:R:M132	2.88	No	No	8	0	4
218	L:L:L14	R:R:I71	2.85	No	No	0	0	5
219	R:R:I303	R:R:L307	2.85	No	No	0	5	5
220	R:R:L114	R:R:M92	2.83	No	No	0	7	7
221	R:R:I107	R:R:N190	2.83	No	No	0	5	7
222	R:R:I280	R:R:N276	2.83	No	No	0	8	5
223	R:R:Q316	R:R:T313	2.83	No	No	0	3	3
224	R:R:G138	R:R:W135	2.81	No	Yes	0	7	8
225	R:R:C172	R:R:R260	2.79	No	No	0	7	5
226	R:R:A170	R:R:R181	2.77	No	No	0	8	7
227	R:R:H321	R:R:T317	2.74	Yes	No	0	4	4
228	R:R:D274	R:R:L277	2.71	No	No	0	1	6
229	R:R:P226	R:R:W230	2.7	No	No	0	4	1
230	R:R:R260	R:R:S263	2.64	No	No	0	5	3
231	R:R:F243	R:R:V247	2.62	Yes	No	0	8	6
232	R:R:F291	R:R:V247	2.62	Yes	No	0	9	6
233	R:R:C161	R:R:W158	2.61	No	No	0	7	5
234	R:R:F223	R:R:T227	2.59	Yes	No	0	6	3
235	R:R:S198	R:R:Y151	2.54	No	Yes	0	4	5
236	R:R:F241	R:R:M245	2.49	No	No	0	4	5
237	R:R:D218	R:R:R213	2.38	No	No	0	4	2
238	R:R:E351	R:R:F352	2.33	No	No	0	3	7
239	R:R:R278	R:R:R282	2.13	No	No	0	5	5
240	L:L:G2	L:L:G3	2.11	No	No	0	0	0
241	R:R:G201	R:R:S147	1.86	No	No	0	6	6
242	R:R:G269	R:R:S268	1.86	No	No	0	1	4
243	R:R:G84	R:R:T120	1.82	No	No	0	8	5
244	R:R:A104	R:R:A186	1.79	No	No	0	5	7
245	R:R:G201	R:R:I200	1.76	No	No	0	6	5
246	R:R:G327	R:R:I298	1.76	No	No	0	7	6
247	R:R:P183	R:R:T182	1.75	No	No	0	1	7
248	L:L:P13	L:L:T12	1.75	No	No	0	0	0
249	R:R:G87	R:R:L90	1.71	No	No	0	8	6
250	R:R:A119	R:R:S331	1.71	No	No	0	7	9
251	R:R:C348	R:R:T99	1.69	No	Yes	0	6	6
252	R:R:I310	R:R:P311	1.69	No	No	0	4	1
253	L:L:P13	R:R:M67	1.68	No	No	0	0	2
254	R:R:M207	R:R:P203	1.68	No	No	0	5	8
255	R:R:M245	R:R:P246	1.68	No	No	0	5	8
256	R:R:C192	R:R:I188	1.64	No	No	0	2	3
257	R:R:C253	R:R:I249	1.64	No	No	0	8	6
258	R:R:V286	R:R:V290	1.6	No	No	0	6	7
259	R:R:T69	R:R:V318	1.59	No	No	2	4	1
260	R:R:C237	R:R:L233	1.59	No	No	0	5	3
261	R:R:T251	R:R:V247	1.59	No	No	0	5	6
262	R:R:T251	R:R:V288	1.59	No	No	0	5	8
263	R:R:T314	R:R:V318	1.59	No	No	2	1	1
264	R:R:T139	R:R:T209	1.57	No	No	0	3	5
265	R:R:A306	R:R:N232	1.56	No	No	0	4	2
266	R:R:I79	R:R:V83	1.54	No	No	0	4	5
267	R:R:I310	R:R:V308	1.54	No	No	0	4	2
268	R:R:M74	R:R:S78	1.53	No	No	0	5	4
269	R:R:H173	R:R:P174	1.53	Yes	No	0	6	8
270	L:L:S7	R:R:K305	1.53	No	No	0	0	3
271	R:R:I68	R:R:T72	1.52	No	No	0	3	4
272	R:R:M132	R:R:V128	1.52	No	No	0	4	3
273	L:L:V15	R:R:M132	1.52	Yes	No	8	0	4
274	L:L:K19	L:L:V15	1.52	No	Yes	8	0	0
275	R:R:F86	R:R:G87	1.51	No	No	0	5	8
276	R:R:K102	R:R:T103	1.5	No	No	0	7	7
277	R:R:L76	R:R:V80	1.49	No	No	0	5	7
278	R:R:L90	R:R:V94	1.49	No	No	0	6	7
279	R:R:L256	R:R:V252	1.49	No	No	0	5	4
280	R:R:I140	R:R:I144	1.47	No	No	0	1	5
281	R:R:N185	R:R:T182	1.46	No	No	0	4	7
282	L:L:N20	L:L:T16	1.46	No	No	0	0	0
283	R:R:I258	R:R:K262	1.45	No	No	0	5	4
284	R:R:E272	R:R:S270	1.44	No	No	0	3	2
285	R:R:I244	R:R:L248	1.43	No	No	0	4	3
286	R:R:I280	R:R:L261	1.43	No	No	0	8	8
287	R:R:E312	R:R:T317	1.41	No	No	0	2	4
288	R:R:A177	R:R:R181	1.38	No	No	0	6	7
289	R:R:L256	R:R:L259	1.38	No	No	0	5	2
290	R:R:L337	R:R:L341	1.38	Yes	No	0	8	7
291	L:L:L14	L:L:L17	1.38	No	No	0	0	0
292	R:R:H173	R:R:K176	1.31	Yes	No	0	6	4
293	R:R:F315	R:R:T313	1.3	No	No	0	2	3
294	L:L:T6	R:R:R213	1.29	No	No	0	0	2
295	R:R:F239	R:R:I240	1.26	Yes	No	0	6	5
296	R:R:T99	R:R:Y98	1.25	Yes	No	0	6	4
297	R:R:F322	R:R:L76	1.22	No	No	0	4	5
298	R:R:I217	R:R:Y212	1.21	No	No	0	4	3
299	R:R:E343	R:R:R279	1.16	No	No	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V91	3.345	4	0	9
2	R:R:T99	3.495	4	6	6
3	R:R:Y108	6.51	5	0	7
4	R:R:D116	8.0875	4	0	9
5	R:R:L123	4.175	4	0	7
6	R:R:W135	11.114	5	4	8
7	R:R:F137	8.426	5	0	6
8	R:R:C142	5.115	4	4	9
9	R:R:I146	4.96	4	4	4
10	R:R:Y151	5.148	5	3	5
11	R:R:T155	7.6375	4	3	7
12	R:R:Y168	7.215	4	9	8
13	R:R:H173	2.905	4	9	6
14	R:R:W194	8.6025	4	3	9
15	R:R:F223	4.73333	6	0	6
16	R:R:F239	4.706	5	10	6
17	R:R:F243	5.475	4	10	8
18	R:R:Y254	6.93	5	1	9
19	R:R:F291	5.5025	4	1	9
20	R:R:W295	7.964	5	1	8
21	R:R:T296	5.045	4	0	5
22	R:R:Y301	5.2075	4	0	5
23	R:R:W320	6.708	5	5	4
24	R:R:H321	7.7875	4	2	4
25	R:R:N330	7.42	4	1	9
26	R:R:N334	6.54	4	1	9
27	R:R:L337	4.4175	4	0	8
28	R:R:Y338	5.316	5	1	9
29	R:R:F345	5.716	5	6	8
30	L:L:Y1	5.524	5	0	0
31	L:L:V15	2.67	4	8	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P13	L:L:T12	20.1636	1.75	No	No	0	0	0
2	L:L:T12	L:L:V15	25.4191	3.17	No	Yes	0	0	0
3	L:L:V15	R:R:M132	39.1627	1.52	Yes	No	8	0	4
4	R:R:M132	R:R:V128	44.5889	1.52	No	No	0	4	3
5	R:R:F137	R:R:V128	47.3396	5.24	Yes	No	0	6	3
6	R:R:F137	R:R:W135	60.9678	20.04	Yes	Yes	0	6	8
7	R:R:C142	R:R:W135	35.644	6.53	Yes	Yes	4	9	8
8	R:R:C142	R:R:I146	58.8194	3.27	Yes	Yes	4	9	4
9	L:L:F4	R:R:I146	95.2063	10.05	No	Yes	0	0	4
10	L:L:F4	R:R:Q126	96.15	8.2	No	No	0	0	6
11	R:R:Q126	R:R:Y328	96.3859	7.89	No	No	7	6	7
12	R:R:L123	R:R:Y328	100	4.69	Yes	No	0	7	7
13	R:R:L123	R:R:Y77	47.9721	5.86	Yes	No	0	7	7
14	R:R:H321	R:R:Y77	11.8864	9.8	Yes	No	0	4	7
15	R:R:C219	R:R:W135	33.3601	18.28	No	Yes	4	9	8
16	R:R:C219	R:R:I146	34.4845	3.27	No	Yes	4	9	4
17	L:L:V15	R:R:L131	11.53	4.47	Yes	No	0	0	4
18	R:R:I324	R:R:Y77	44.6692	7.25	No	No	0	5	7
19	R:R:C81	R:R:L123	69.8574	3.17	No	Yes	0	6	7
20	R:R:C81	R:R:L85	70.1887	3.17	No	No	0	6	6
21	R:R:L85	R:R:T120	70.5	5.9	No	No	0	6	5
22	R:R:S331	R:R:T120	72.5078	3.2	No	No	0	9	5
23	R:R:D116	R:R:S331	73.2607	10.31	Yes	No	0	9	9
24	R:R:D116	R:R:N88	43.7356	6.73	Yes	No	0	9	9
25	R:R:N88	R:R:P335	41.1957	4.89	No	No	0	9	9
26	R:R:P335	R:R:V91	31.9898	3.53	No	Yes	0	9	9
27	R:R:I95	R:R:V91	27.8938	3.07	No	Yes	0	7	9
28	R:R:F345	R:R:I95	22.2819	6.28	Yes	No	0	8	7
29	R:R:F345	R:R:T99	10.6415	5.19	Yes	Yes	6	8	6
30	R:R:D116	R:R:N334	84.8359	9.42	Yes	Yes	0	9	9
31	R:R:N334	R:R:Y338	72.5881	5.81	Yes	Yes	1	9	9
32	R:R:M163	R:R:Y338	48.198	4.79	No	Yes	0	9	9
33	R:R:M163	R:R:Y108	47.2041	3.59	No	Yes	0	9	7
34	R:R:D166	R:R:Y108	15.7012	5.75	No	Yes	0	8	7
35	R:R:N190	R:R:Y108	27.9038	11.63	No	Yes	0	7	7
36	R:R:N111	R:R:N190	23.9735	9.54	No	No	0	9	7
37	R:R:N111	R:R:W194	22.6433	5.65	No	Yes	0	9	9
38	R:R:W194	R:R:Y151	14.3008	9.65	Yes	Yes	3	9	5
39	R:R:D218	R:R:S216	10.7469	5.89	No	No	0	4	1
40	R:R:S216	R:R:T134	12.2427	3.2	No	No	0	1	5
41	R:R:I217	R:R:T134	13.7285	4.56	No	No	0	4	5
42	R:R:I217	R:R:T210	18.1257	4.56	No	No	0	4	4
43	R:R:C142	R:R:T210	26.6489	3.38	Yes	No	0	9	4
44	R:R:I324	R:R:W320	43.5298	5.87	No	Yes	5	5	4
45	L:L:M5	R:R:W320	51.9827	4.65	No	Yes	0	0	4
46	L:L:M5	L:L:Y1	52.3441	3.59	No	Yes	0	0	0
47	L:L:Y1	R:R:V238	35.0366	6.31	Yes	No	0	0	5
48	L:L:Y1	R:R:M153	61.0631	5.99	Yes	No	0	0	7
49	R:R:M153	R:R:W295	61.2489	4.65	No	Yes	0	7	8
50	R:R:F291	R:R:W295	25.5798	7.02	Yes	Yes	1	9	8
51	R:R:F291	R:R:I250	29.0734	7.54	Yes	No	1	9	8
52	R:R:N330	R:R:N334	49.6486	6.81	Yes	Yes	1	9	9
53	R:R:F291	R:R:N330	16.9762	4.83	Yes	Yes	1	9	9
54	R:R:I250	R:R:S164	18.964	4.64	No	No	1	8	9
55	R:R:R167	R:R:Y338	36.3568	3.09	No	Yes	0	9	9
56	R:R:R167	R:R:Y254	30.1626	8.23	No	Yes	0	9	9
57	R:R:S164	R:R:Y254	13.2266	10.17	No	Yes	1	9	9
58	R:R:C253	R:R:S164	29.7611	3.44	No	No	0	8	9
59	R:R:D166	R:R:F180	10.0793	4.78	No	No	0	8	3
60	R:R:M257	R:R:R167	16.3437	4.96	No	No	0	8	9
61	R:R:C253	R:R:Y168	24.862	9.41	No	Yes	0	8	8
62	R:R:M257	R:R:V171	14.5267	7.61	No	No	0	8	8
63	R:R:L234	R:R:V238	26.7845	2.98	No	No	0	6	5
64	R:R:F223	R:R:L234	25.374	3.65	Yes	No	0	6	6
65	R:R:F223	R:R:W230	12.3632	3.01	Yes	No	0	6	1
66	R:R:H299	R:R:W295	17.2222	7.41	No	Yes	0	7	8
67	R:R:F239	R:R:H299	14.4815	4.53	Yes	No	0	6	7
68	R:R:F291	R:R:V247	15.2746	2.62	Yes	No	0	9	6
69	R:R:F243	R:R:V247	12.3984	2.62	Yes	No	0	8	6
70	R:R:F243	R:R:T296	12.5439	9.08	Yes	Yes	0	8	5
71	R:R:V284	R:R:Y254	15.2946	8.83	No	Yes	0	8	9
72	R:R:I258	R:R:V284	13.9444	4.61	No	No	0	5	8
73	R:R:I258	R:R:T281	10.9126	4.56	No	No	0	5	6
74	R:R:L261	R:R:V171	12.6895	2.98	No	No	0	8	8
75	R:R:I280	R:R:L261	10.8473	1.43	No	No	0	8	8
76	R:R:L337	R:R:Y338	10.0893	5.86	Yes	Yes	0	8	9
77	R:R:W320	R:R:Y301	16.8106	5.79	Yes	Yes	0	4	5
78	R:R:I71	R:R:M67	11.5802	2.92	No	No	0	5	2
79	L:L:P13	R:R:M67	14.4514	1.68	No	No	0	0	2
80	R:R:N330	R:R:W295	31.5832	10.17	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P13	R:R:S66	3.56	0	No	No	0	7	0	1
L:L:T12	R:R:A70	3.36	0	No	No	0	4	0	1
R:R:L131	R:R:M74	11.31	0	No	No	4	5	1	2
R:R:I324	R:R:Y77	7.25	5	No	No	5	7	1	2
R:R:D149	R:R:Q126	3.92	7	No	No	5	6	2	1
R:R:Q126	R:R:Y328	7.89	7	No	No	6	7	1	2
L:L:F4	R:R:Q126	8.2	0	No	No	0	6	0	1
L:L:V15	R:R:L131	4.47	8	Yes	No	0	4	0	1
L:L:K9	R:R:G133	5.23	0	No	No	0	2	0	1
R:R:C142	R:R:I146	3.27	4	Yes	Yes	9	4	2	1
R:R:C142	R:R:C219	7.28	4	Yes	No	9	9	2	2
R:R:A208	R:R:I146	3.25	0	No	Yes	5	4	2	1
R:R:C219	R:R:I146	3.27	4	No	Yes	9	4	2	1
L:L:F4	R:R:I146	10.05	0	No	Yes	0	4	0	1
R:R:D149	R:R:Y328	8.05	7	No	No	5	7	2	2
R:R:V204	R:R:Y150	7.57	0	No	No	5	4	2	1
L:L:Y1	R:R:Y150	7.94	0	Yes	No	0	4	0	1
R:R:M153	R:R:W295	4.65	0	No	Yes	7	8	1	2
L:L:Y1	R:R:M153	5.99	0	Yes	No	0	7	0	1
R:R:F154	R:R:V238	5.24	0	No	No	6	5	2	1
L:L:E8	R:R:R213	5.82	0	No	No	0	2	0	1
L:L:E8	R:R:Q214	3.82	0	No	No	0	2	0	1
R:R:D218	R:R:S216	5.89	0	No	No	4	1	1	2
L:L:K9	R:R:D218	4.15	0	No	No	0	4	0	1
L:L:Y1	R:R:V238	6.31	0	Yes	No	0	5	0	1
R:R:W320	R:R:Y301	5.79	5	Yes	Yes	4	5	1	2
L:L:Y1	R:R:V302	3.79	0	Yes	No	0	5	0	1
R:R:K305	R:R:W320	11.6	0	No	Yes	3	4	1	1
R:R:I324	R:R:W320	5.87	5	No	Yes	5	4	1	1
L:L:G2	R:R:W320	5.63	5	No	Yes	0	4	0	1
L:L:M5	R:R:W320	4.65	0	No	Yes	0	4	0	1
L:L:G2	R:R:I324	3.53	5	No	No	0	5	0	1
R:R:L234	R:R:V238	2.98	0	No	No	6	5	2	1
R:R:I71	R:R:M67	2.92	0	No	No	5	2	1	1
L:L:K19	R:R:M132	2.88	8	No	No	0	4	0	1
L:L:L14	R:R:I71	2.85	0	No	No	0	5	0	1
R:R:D218	R:R:R213	2.38	0	No	No	4	2	1	1
L:L:P13	R:R:M67	1.68	0	No	No	0	2	0	1
L:L:S7	R:R:K305	1.53	0	No	No	0	3	0	1
R:R:M132	R:R:V128	1.52	8	No	No	4	3	1	2
L:L:V15	R:R:M132	1.52	8	Yes	No	0	4	0	1
L:L:T6	R:R:R213	1.29	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F7Q_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	287
Number of Links	299
Number of Hubs	31
Number of Links mediated by Hubs	119
Number of Communities	10
Number of Nodes involved in Communities	41
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	47653
Length Of Smallest Path	3
Average Path Length	15.3569
Length of Longest Path	34
Minimum Path Strength	1.355
Average Path Strength	5.81802
Maximum Path Strength	19.16
Minimum Path Correlation	0.7
Average Path Correlation	0.923609
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	47.09
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.8138
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • protein binding • binding • G-protein beta-subunit binding • neuropeptide binding • peptide binding • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • regulation of biological process • regulation of cellular process • biological regulation • positive regulation of biological process • reactive nitrogen species metabolic process • positive regulation of nitric oxide metabolic process • nitric oxide metabolic process • positive regulation of metabolic process • nitric oxide biosynthetic process • biosynthetic process • positive regulation of biosynthetic process • cellular process
Gene Ontology	Biological Process	• regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • regulation of biological process • regulation of cellular process • biological regulation • positive regulation of biological process • reactive nitrogen species metabolic process • positive regulation of nitric oxide metabolic process • nitric oxide metabolic process • positive regulation of metabolic process • nitric oxide biosynthetic process • biosynthetic process • positive regulation of biosynthetic process • cellular process • metabolic process • regulation of nitric oxide metabolic process • positive regulation of nitric oxide biosynthetic process • regulation of metabolic process • positive regulation of cellular process • cellular response to stimulus • response to stimulus • signaling • cell communication • G protein-coupled receptor signaling pathway • signal transduction • neuropeptide signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • regulation of transporter activity • localization • regulation of NMDA receptor activity • regulation of monoatomic ion transmembrane transporter activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • cAMP-mediated signaling • positive regulation of cAMP-mediated signaling • regulation of cAMP-mediated signaling • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • negative regulation of metabolic process • negative regulation of biological process • negative regulation of nitric oxide metabolic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • multicellular organismal process • system process • sensory perception • nervous system process • behavior • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • negative regulation of signaling • negative regulation of intracellular signal transduction • negative regulation of cell communication • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of cAMP-mediated signaling • sensory perception of pain • protein localization • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of secretion by cell • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of protein localization • negative regulation of Wnt protein secretion • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • signal release • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • regulation of establishment of protein localization • export from cell • regulation of protein transport • Wnt protein secretion • protein transport • regulation of cellular localization • macromolecule localization • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle
Gene Ontology	Cellular Component	• somatodendritic compartment • cell body • cellular anatomical structure • perikaryon • neuronal cell body • cell periphery • plasma membrane • membrane • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle • synapse • cell junction • axon • endoplasmic reticulum • protein binding • binding • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • regulation of localization • corticosterone secretion • regulation of system process • regulation of glucocorticoid secretion • localization • regulation of steroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • transport • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • cell-cell signaling • endocrine process • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • secretory granule • secretory vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • D2 dopamine receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • intracellular membraneless organelle • nucleolus • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • cilium • ciliary basal body • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P35372
Sequence	>8F7Q_nogp_Chain_R S M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G T I L C K I V I S I D Y Y N M F T S I W T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I I N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	10.1101/2025.01.09.632033
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	10.1101/2025.01.09.632033
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	10.1021/acscentsci.4c00525
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	VV9	Gi3/β1/γ1	3.05	2024-05-29	10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	VV9		3.05	2024-05-29	10.1038/s41467-024-47792-6
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	10.1038/s41467-024-47792-6
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	10.1101/2023.12.06.570395
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	10.1186/s12915-023-01689-w
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	10.1016/j.cell.2022.12.026
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	10.1016/j.cell.2022.12.026
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	10.1038/s41589-022-01208-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	10.1038/s41586-022-05588-y
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	10.1016/j.cell.2022.09.041
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	10.1016/j.cell.2022.09.041
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	10.1038/s41594-022-00859-8
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	10.1038/s41586-022-05588-y
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	10.1002/anie.202200269
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	10.1002/anie.202200269
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	10.1038/s41586-018-0219-7
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	10.1038/s41586-018-0219-7
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	10.1038/nature14886
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	10.1038/nature10954

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