Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y1 9.008500
2L:L:?2 9.43510
3L:L:?4 10.4867610
4R:R:I107 5.61405
5R:R:Y108 5.63167607
6R:R:F110 5.9525406
7R:R:T122 4.2416
8R:R:Q126 6.148516
9R:R:W135 7.84667658
10R:R:F137 8.52506
11R:R:I146 4.9075404
12R:R:D149 4.75415
13R:R:Y151 7.33435
14R:R:M153 5.0075407
15R:R:F154 4.2875406
16R:R:T155 5.7075437
17R:R:I157 5.2275427
18R:R:Y168 7.7175468
19R:R:H173 3.4475466
20R:R:W194 9.5875439
21R:R:F223 5.882506
22R:R:W230 3.8775401
23R:R:F239 6.7425426
24R:R:F243 7.176528
25R:R:Y254 9.3425409
26R:R:I258 5.64405
27R:R:L267 3.95501
28R:R:V290 3.0625407
29R:R:W295 6.70333628
30R:R:T296 5.37405
31R:R:Y301 6.6825415
32R:R:Q316 5.31403
33R:R:W320 9.306514
34R:R:H321 9.42414
35R:R:Y328 8.7725417
36R:R:N334 7.9425449
37R:R:Y338 6.782549
38R:R:F345 6.82408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?2 L:L:Y1 93.657915.5YesYes000
2L:L:Y1 R:R:M153 1007.18YesYes007
3L:L:Y1 R:R:V302 19.947410.09YesNo005
4L:L:?2 L:L:G3 39.69556.96YesNo000
5L:L:?4 L:L:G3 39.01510.36YesNo000
6L:L:?4 R:R:I146 58.98878.64YesYes004
7L:L:?2 L:L:?5 44.2037.59YesNo100
8L:L:?4 L:L:?5 39.048922.6YesNo100
9L:L:?2 R:R:W320 19.458612.74YesYes104
10R:R:C219 R:R:I146 53.81953.27NoYes094
11R:R:C219 R:R:W135 24.037615.67NoYes598
12R:R:F137 R:R:W135 15.387214.03YesYes068
13R:R:M153 R:R:W295 31.63164.65YesYes078
14R:R:H299 R:R:W295 31.25563.17NoYes278
15R:R:F243 R:R:H299 27.808312.44YesNo287
16R:R:F243 R:R:T296 21.101510.38YesYes085
17R:R:P297 R:R:T296 23.56393.5NoYes095
18R:R:L326 R:R:P297 21.83834.93NoNo089
19L:L:?4 R:R:Q126 13.263211.52YesYes106
20R:R:F154 R:R:M153 71.43984.98YesYes067
21R:R:F154 R:R:W158 70.15415.01YesNo065
22R:R:C161 R:R:W158 70.03016.53NoNo075
23R:R:C161 R:R:I250 74.56023.27NoNo078
24R:R:I250 R:R:S164 74.55646.19NoNo089
25R:R:S164 R:R:Y254 74.657913.99NoYes099
26R:R:R167 R:R:Y254 89.80838.23NoYes099
27R:R:R167 R:R:Y338 89.27076.17NoYes099
28R:R:N334 R:R:Y338 21.78955.81YesYes499
29R:R:D116 R:R:N334 15.87976.73NoYes099
30R:R:D116 R:R:S331 10.67678.83NoNo099
31R:R:M163 R:R:Y338 64.66929.58NoYes099
32R:R:M163 R:R:Y108 63.93614.79NoYes097
33R:R:N190 R:R:Y108 49.70688.14NoYes077
34R:R:N111 R:R:N190 43.240616.35NoNo097
35R:R:N111 R:R:W194 42.357112.43NoYes099
36R:R:L114 R:R:W194 41.06023.42NoYes079
37R:R:L114 R:R:M92 33.03385.65NoNo077
38R:R:F110 R:R:M92 31.85717.46YesNo067
39R:R:F110 R:R:I95 28.2825.02YesNo067
40R:R:F345 R:R:I95 22.17295.02YesNo087
41R:R:A339 R:R:F345 15.87594.16NoYes068
42R:R:A339 R:R:F340 12.00752.77NoNo066
43R:R:L160 R:R:Y338 10.44363.52NoYes489
44R:R:L112 R:R:N334 14.056412.36NoYes499
45R:R:L112 R:R:T159 21.89477.37NoNo098
46R:R:N193 R:R:T159 20.16924.39NoNo078
47R:R:N193 R:R:S197 18.63164.47NoNo078
48R:R:C142 R:R:C219 28.02267.28NoNo599
49R:R:C142 R:R:T210 26.8913.38NoNo094
50R:R:T139 R:R:T210 15.54514.71NoNo034
51R:R:K143 R:R:T139 13.62783NoNo063
52R:R:S197 R:R:Y151 10.48123.82NoYes385
53R:R:F243 R:R:V247 25.97743.93YesNo086
54R:R:T251 R:R:V247 33.96991.59NoNo056
55R:R:T251 R:R:V252 20.74061.59NoNo054
56R:R:L256 R:R:V252 19.66172.98NoNo054
57R:R:L256 R:R:Y168 17.51888.21NoYes058
58R:R:V284 R:R:Y254 26.778211.36NoYes089
59R:R:I258 R:R:V284 25.79327.68YesNo058
60R:R:I258 R:R:M257 21.53012.92YesNo058
61R:R:M257 R:R:V171 20.45116.09NoNo088
62R:R:L261 R:R:V171 21.22185.96NoNo088
63R:R:I107 R:R:P183 11.23681.69YesNo051
64R:R:K235 R:R:V302 16.63914.55NoNo045
65R:R:E231 R:R:K235 13.27074.05NoNo044
66R:R:E231 R:R:F223 12.101512.83NoYes046
67R:R:T251 R:R:V288 25.05261.59NoNo058
68R:R:I280 R:R:L261 19.84962.85NoNo088
69R:R:I280 R:R:L267 18.57141.43NoYes081
70R:R:L267 R:R:M266 10.20681.41YesNo014
71R:R:L326 R:R:T329 12.86474.42NoNo085
72R:R:C294 R:R:T329 11.04893.38NoNo095
73R:R:V288 R:R:Y254 24.7973.79NoYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y1 R:R:Y150 5.96 0 Yes No 0 4 0 1
L:L:Y1 R:R:M153 7.18 0 Yes Yes 0 7 0 1
L:L:Y1 R:R:V238 6.31 0 Yes No 0 5 0 1
L:L:Y1 R:R:V302 10.09 0 Yes No 0 5 0 1
L:L:?2 R:R:W320 12.74 1 Yes Yes 0 4 0 1
L:L:?2 R:R:I324 4.36 1 Yes No 0 5 0 1
L:L:?4 R:R:Q126 11.52 1 Yes Yes 0 6 0 1
L:L:?4 R:R:I146 8.64 1 Yes Yes 0 4 0 1
L:L:?4 R:R:D149 4.7 1 Yes Yes 0 5 0 1
L:L:?4 R:R:T220 5.1 1 Yes No 0 4 0 1
L:L:?5 R:R:T220 3.97 1 No No 0 4 0 1
R:R:H321 R:R:Y77 9.8 1 Yes No 4 7 2 2
R:R:I324 R:R:Y77 6.04 1 No No 5 7 1 2
R:R:Q126 R:R:T122 5.67 1 Yes Yes 6 6 1 2
R:R:D149 R:R:T122 5.78 1 Yes Yes 5 6 1 2
R:R:T122 R:R:Y328 3.75 1 Yes Yes 6 7 2 2
R:R:L123 R:R:Q126 3.99 1 No Yes 7 6 2 1
R:R:L123 R:R:Y328 21.1 1 No Yes 7 7 2 2
R:R:D149 R:R:Q126 3.92 1 Yes Yes 5 6 1 1
R:R:Q126 R:R:Y328 5.64 1 Yes Yes 6 7 1 2
R:R:A208 R:R:I146 4.87 0 No Yes 5 4 2 1
R:R:C219 R:R:I146 3.27 5 No Yes 9 4 2 1
R:R:D149 R:R:Y328 4.6 1 Yes Yes 5 7 1 2
R:R:V204 R:R:Y150 11.36 0 No No 5 4 2 1
R:R:F154 R:R:M153 4.98 0 Yes Yes 6 7 2 1
R:R:M153 R:R:W295 4.65 0 Yes Yes 7 8 1 2
R:R:K235 R:R:V302 4.55 0 No No 4 5 2 1
R:R:K305 R:R:Y301 4.78 1 No Yes 3 5 2 2
R:R:W320 R:R:Y301 8.68 1 Yes Yes 4 5 1 2
R:R:K305 R:R:W320 11.6 1 No Yes 3 4 2 1
R:R:H321 R:R:W320 5.29 1 Yes Yes 4 4 2 1
R:R:I324 R:R:W320 8.22 1 No Yes 5 4 1 1
R:R:A242 R:R:M153 3.22 0 No Yes 5 7 2 1
R:R:I298 R:R:V302 3.07 0 No No 6 5 2 1
R:R:I146 R:R:L221 2.85 0 Yes No 4 4 1 2
R:R:D218 R:R:T220 1.45 0 No No 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8K9K_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.27
Number of Linked Nodes 265
Number of Links 291
Number of Hubs 38
Number of Links mediated by Hubs 142
Number of Communities 7
Number of Nodes involved in Communities 40
Number of Links involved in Communities 52
Path Summary
Number Of Nodes in MetaPath 74
Number Of Links MetaPath 73
Number of Shortest Paths 53534
Length Of Smallest Path 3
Average Path Length 16.4104
Length of Longest Path 39
Minimum Path Strength 1.22
Average Path Strength 6.76723
Maximum Path Strength 15.62
Minimum Path Correlation 0.7
Average Path Correlation 0.923025
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 43.7546
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.7764
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDAL
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeDAL
NameD-Alanine
Synonyms(R)-alanine
Identifier
FormulaC3 H7 N O2
Molecular Weight89.093
SMILES
PubChem71080
Formal Charge0
Total Atoms13
Total Chiral Atoms1
Total Bonds12
Total Aromatic Bonds0

CodeMEA
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeMEA
NameN-METHYLPHENYLALANINE
Synonyms
Identifier
FormulaC10 H13 N O2
Molecular Weight179.216
SMILES
PubChem6951134
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6

CodeETA
PDB ResiduesL:L:?5
Environment DetailsOpen EMBL-EBI Page
CodeETA
NameEthanolamine
Synonyms
  • Ethanolamine hydrochloride
  • Ethanolamine acetate
  • Ethanolamine
Identifier
FormulaC2 H7 N O
Molecular Weight61.083
SMILES
PubChem700
Formal Charge0
Total Atoms11
Total Chiral Atoms0
Total Bonds10
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP35372
Sequence
>8K9K_nogp_Chain_R
SMITAITIM ALYSIVCVV GLFGNFLVM YVIVRYTKM KTATNIYIF 
NLALADALA TSTLPFQSV NYLMGTWPF GTILCKIVI SIDYYNMFT 
SIWTLCTMS VDRYIAVCH PVKALDFRT PRNAKIINV CNWILSSAI 
GLPVMFMAT TKYRQGSID CTLTFSHPT WYWENLLKI CVFIFAFIM 
PVLIITVCY GLMILRLKS VRMLSGSKE KDRNLRRIT RMVLVVVAV 
FIVCWTPIH IYVIIKALV TIPETTFQT VSWHFCIAL GYTNSCLNP 
VLYAFLDEN FKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BJKAPeptideOpioidμMus musculusNaloxoneNAM-3.262024-07-17doi.org/10.1038/s41586-024-07587-7
8K9LAPeptideOpioidμHomo sapiensDamgoBMS-986122Gi3/β1/γ13.052024-05-29doi.org/10.1038/s41467-024-47792-6
8K9L (No Gprot) APeptideOpioidμHomo sapiensDamgoBMS-9861223.052024-05-29doi.org/10.1038/s41467-024-47792-6
7SBFAPeptideOpioidμMus musculusPZM21-Gi1/β1/γ22.92022-04-20doi.org/10.1002/anie.202200269
7SBF (No Gprot) APeptideOpioidμMus musculusPZM21-2.92022-04-20doi.org/10.1002/anie.202200269
7SCGAPeptideOpioidμMus musculusFH210-Gi1/β1/γ232022-04-20doi.org/10.1002/anie.202200269
7SCG (No Gprot) APeptideOpioidμMus musculusFH210-32022-04-20doi.org/10.1002/anie.202200269
8EF5APeptideOpioidμHomo sapiensFentanyl-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF5 (No Gprot) APeptideOpioidμHomo sapiensFentanyl-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6APeptideOpioidμHomo sapiensMorphine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6 (No Gprot) APeptideOpioidμHomo sapiensMorphine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFBAPeptideOpioidμHomo sapiensOliceridine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFB (No Gprot) APeptideOpioidμHomo sapiensOliceridine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFLAPeptideOpioidμHomo sapiensSR17018-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFL (No Gprot) APeptideOpioidμHomo sapiensSR17018-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFOAPeptideOpioidμHomo sapiensPZM21-Gi1/β1/γ22.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFO (No Gprot) APeptideOpioidμHomo sapiensPZM21-2.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQAPeptideOpioidμHomo sapiensDamgo-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQ (No Gprot) APeptideOpioidμHomo sapiensDamgo-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8F7QAPeptideOpioidμHomo sapiensβ-Endorphin-Gi1/β1/γ23.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7Q (No Gprot) APeptideOpioidμHomo sapiensβ-Endorphin-3.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7RAPeptideOpioidμHomo sapiensEndomorphin-Gi1/β1/γ23.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7R (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-3.282022-12-14doi.org/10.1016/j.cell.2022.12.026
9BQJAPeptideOpioidμMus musculusRO76-Gi1/β1/γ23.32024-09-11doi.org/10.1021/acscentsci.4c00525
9BQJ (No Gprot) APeptideOpioidμMus musculusRO76-3.32024-09-11doi.org/10.1021/acscentsci.4c00525
4DKLAPeptideOpioidμMus musculusβ-Funaltrexamine--2.82012-03-21doi.org/10.1038/nature10954
5C1MAPeptideOpioidμMus musculusBU72--2.072015-08-05doi.org/10.1038/nature14886
8K9KAPeptideOpioidμHomo sapiensDamgo-Gi3/β1/γ12.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9K (No Gprot) APeptideOpioidμHomo sapiensDamgo-2.982024-05-29doi.org/10.1038/s41467-024-47792-6
6DDEAPeptideOpioidμMus musculusDamgo-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDE (No Gprot) APeptideOpioidμMus musculusDamgo-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDFAPeptideOpioidμMus musculusDamgo-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDF (No Gprot) APeptideOpioidμMus musculusDamgo-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
7U2LAPeptideOpioidμMus musculusPubChem 163201242-Gi1/β1/γ23.22022-05-04doi.org/10.1038/s41586-022-05588-y
7U2L (No Gprot) APeptideOpioidμMus musculusPubChem 163201242-3.22022-05-04doi.org/10.1038/s41586-022-05588-y
7U2KAPeptideOpioidμMus musculusC6-guano-Gi1/β1/γ23.32022-12-07doi.org/10.1038/s41586-022-05588-y
7U2K (No Gprot) APeptideOpioidμMus musculusC6-guano-3.32022-12-07doi.org/10.1038/s41586-022-05588-y
7T2GAPeptideOpioidμMus musculusMitragynine Pseudoindoxyl-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2G (No Gprot) APeptideOpioidμMus musculusMitragynine Pseudoindoxyl-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2HAPeptideOpioidμMus musculusLofentanil-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2H (No Gprot) APeptideOpioidμMus musculusLofentanil-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7UL4APeptideOpioidμMus musculusAlvimopan--2.82022-06-29doi.org/10.1038/s41594-022-00859-8
8QOTAPeptideOpioidμMus musculusNanobody-E--3.22023-12-27doi.org/10.1101/2023.12.06.570395
9MQHAPeptideOpioidμHomo sapiens---3.92025-02-12doi.org/10.1101/2025.01.09.632033
9MQIAPeptideOpioidμHomo sapiensIsoquinuclidine--3.32025-02-12doi.org/10.1101/2025.01.09.632033
9MQJAPeptideOpioidμHomo sapiensIsoquinuclidine--3.232025-02-12doi.org/10.1101/2025.01.09.632033
8E0GAPeptideOpioidμMus musculusBU72--2.12023-10-18doi.org/10.1186/s12915-023-01689-w
8Y73APeptideOpioidμHomo sapiensPeptideMPAM-15Gi1/β1/γ22.842025-08-06To be published
8Y73 (No Gprot) APeptideOpioidμHomo sapiensPeptideMPAM-152.842025-08-06To be published
8Y72APeptideOpioidμHomo sapiensPeptideBMS-986122Gi1/β1/γ22.652025-08-06To be published
8Y72 (No Gprot) APeptideOpioidμHomo sapiensPeptideBMS-9861222.652025-08-06To be published




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