psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q124	13.34	Yes	Yes	0	0	6
2	L:L:?1	R:R:I144	5.2	Yes	No	0	0	5
3	L:L:?1	R:R:D147	14.84	Yes	No	0	0	6
4	L:L:?1	R:R:Y148	11.75	Yes	No	0	0	4
5	L:L:?1	R:R:M151	21.9	Yes	No	0	0	7
6	L:L:?1	R:R:C217	5.79	Yes	No	0	0	9
7	L:L:?1	R:R:W293	8.3	Yes	Yes	0	0	8
8	L:L:?1	R:R:H297	5.86	Yes	Yes	0	0	8
9	R:R:A68	R:R:Y128	4	No	Yes	0	4	5
10	R:R:I71	R:R:Y75	10.88	No	Yes	2	4	7
11	R:R:I71	R:R:Y128	12.09	No	Yes	2	4	5
12	R:R:H319	R:R:I71	10.61	Yes	No	2	4	4
13	R:R:M72	R:R:S125	4.6	No	No	0	5	6
14	R:R:L129	R:R:M72	7.07	No	No	0	5	5
15	R:R:L121	R:R:Y75	10.55	Yes	Yes	2	7	7
16	R:R:H319	R:R:Y75	4.36	Yes	Yes	2	4	7
17	R:R:I322	R:R:Y75	3.63	No	Yes	0	5	7
18	R:R:I77	R:R:V78	3.07	No	No	0	5	7
19	R:R:I77	R:R:V81	3.07	No	No	0	5	5
20	R:R:L121	R:R:V78	2.98	Yes	No	0	7	7
21	R:R:C79	R:R:L83	3.17	No	No	0	6	6
22	R:R:C79	R:R:L121	6.35	No	Yes	0	6	7
23	R:R:C79	R:R:P122	3.77	No	No	0	6	8
24	R:R:F87	R:R:L83	7.31	No	No	0	4	6
25	R:R:L83	R:R:T118	2.95	No	No	0	6	6
26	R:R:D114	R:R:N86	12.12	No	No	1	9	9
27	R:R:A115	R:R:N86	4.69	No	No	0	7	9
28	R:R:N86	R:R:P333	3.26	No	No	1	9	9
29	R:R:I93	R:R:V89	3.07	Yes	No	0	7	9
30	R:R:F108	R:R:M90	3.73	Yes	No	0	6	7
31	R:R:L112	R:R:M90	5.65	No	No	0	6	7
32	R:R:F343	R:R:V92	3.93	Yes	No	0	9	7
33	R:R:I93	R:R:M99	2.92	Yes	No	7	7	7
34	R:R:I107	R:R:I93	2.94	No	Yes	0	8	7
35	R:R:F108	R:R:I93	3.77	Yes	Yes	7	6	7
36	R:R:F343	R:R:I93	5.02	Yes	Yes	0	9	7
37	R:R:F108	R:R:V94	3.93	Yes	No	0	6	3
38	R:R:R95	R:R:Y96	3.09	No	No	0	4	5
39	R:R:K100	R:R:T97	10.51	No	No	4	6	6
40	R:R:N104	R:R:T97	7.31	No	No	4	8	6
41	R:R:F108	R:R:M99	8.71	Yes	No	7	6	7
42	R:R:K100	R:R:T101	3	No	No	4	6	8
43	R:R:K100	R:R:N104	5.6	No	No	4	6	8
44	R:R:T101	R:R:T103	3.14	No	No	0	8	8
45	R:R:N104	R:R:T101	4.39	No	No	4	8	8
46	R:R:I107	R:R:T103	3.04	No	No	0	8	8
47	R:R:I105	R:R:K185	4.36	No	No	0	6	2
48	R:R:T160	R:R:Y106	7.49	No	Yes	0	7	7
49	R:R:M161	R:R:Y106	4.79	No	Yes	0	8	7
50	R:R:D164	R:R:Y106	4.6	No	Yes	0	8	7
51	R:R:D340	R:R:I107	2.8	Yes	No	0	8	8
52	R:R:N109	R:R:T157	5.85	No	No	0	9	7
53	R:R:N109	R:R:N188	17.71	No	No	3	9	7
54	R:R:N109	R:R:W192	12.43	No	Yes	3	9	9
55	R:R:L110	R:R:S154	3	No	No	0	9	9
56	R:R:L110	R:R:T157	4.42	No	No	0	9	7
57	R:R:L110	R:R:N332	10.98	No	Yes	0	9	9
58	R:R:A113	R:R:T153	3.36	No	Yes	0	8	7
59	R:R:D114	R:R:S329	8.83	No	No	0	9	9
60	R:R:D114	R:R:P333	3.22	No	No	1	9	9
61	R:R:L116	R:R:N150	12.36	No	Yes	0	7	8
62	R:R:A117	R:R:N150	4.69	No	Yes	0	7	8
63	R:R:T118	R:R:Y326	4.99	No	Yes	0	6	7
64	R:R:Q124	R:R:T120	4.25	Yes	No	0	6	6
65	R:R:I146	R:R:T120	3.04	No	No	0	5	6
66	R:R:L121	R:R:Q124	3.99	Yes	Yes	2	7	6
67	R:R:L121	R:R:Y326	12.89	Yes	Yes	2	7	7
68	R:R:F123	R:R:F135	6.43	No	Yes	0	6	7
69	R:R:Q124	R:R:Y326	3.38	Yes	Yes	2	6	7
70	R:R:M130	R:R:V126	3.04	No	No	0	3	5
71	R:R:N127	R:R:W133	9.04	No	Yes	0	6	8
72	R:R:L129	R:R:Y128	4.69	No	Yes	0	5	5
73	R:R:H319	R:R:Y128	10.89	Yes	Yes	2	4	5
74	R:R:F135	R:R:W133	22.05	Yes	Yes	0	7	8
75	R:R:C140	R:R:W133	6.53	No	Yes	5	9	8
76	R:R:C217	R:R:W133	7.84	No	Yes	5	9	8
77	R:R:F135	R:R:P134	4.33	Yes	No	0	7	4
78	R:R:F135	R:R:L139	7.31	Yes	No	0	7	6
79	R:R:K141	R:R:N137	6.99	Yes	No	0	6	1
80	R:R:N137	R:R:T208	10.24	No	No	0	1	5
81	R:R:I142	R:R:L139	2.85	No	No	0	5	6
82	R:R:C140	R:R:I144	3.27	No	No	0	9	5
83	R:R:C140	R:R:C217	5.46	No	No	5	9	9
84	R:R:K141	R:R:M203	2.88	Yes	No	0	6	4
85	R:R:K141	R:R:T207	3	Yes	No	0	6	5
86	R:R:A206	R:R:I144	4.87	No	No	0	4	5
87	R:R:M203	R:R:S145	6.13	No	No	0	4	6
88	R:R:D147	R:R:Y326	3.45	No	Yes	0	6	7
89	R:R:N150	R:R:Y149	4.65	Yes	Yes	3	8	4
90	R:R:T153	R:R:Y149	7.49	Yes	Yes	3	7	4
91	R:R:W192	R:R:Y149	8.68	Yes	Yes	3	9	4
92	R:R:S195	R:R:Y149	3.82	No	Yes	3	8	4
93	R:R:S196	R:R:Y149	3.82	No	Yes	0	3	4
94	R:R:N150	R:R:T153	4.39	Yes	Yes	3	8	7
95	R:R:F152	R:R:F156	5.36	Yes	No	0	7	6
96	R:R:F152	R:R:I198	3.77	Yes	No	0	7	4
97	R:R:A240	R:R:F152	2.77	No	Yes	0	6	7
98	R:R:T153	R:R:W192	4.85	Yes	Yes	3	7	9
99	R:R:S195	R:R:T153	4.8	No	Yes	3	8	7
100	R:R:I155	R:R:P244	3.39	No	No	0	8	9
101	R:R:F289	R:R:I155	3.77	No	No	6	9	8
102	R:R:I155	R:R:W293	4.7	No	Yes	6	8	8
103	R:R:F156	R:R:N191	4.83	No	No	0	6	7
104	R:R:F156	R:R:S195	3.96	No	No	0	6	8
105	R:R:L158	R:R:N332	4.12	No	Yes	1	8	9
106	R:R:L158	R:R:Y336	3.52	No	Yes	1	8	9
107	R:R:C159	R:R:P244	3.77	No	No	0	7	9
108	R:R:C159	R:R:I247	3.27	No	No	0	7	7
109	R:R:T160	R:R:V187	3.17	No	No	8	7	5
110	R:R:N191	R:R:T160	7.31	No	No	8	7	7
111	R:R:M161	R:R:Y336	4.79	No	Yes	0	8	9
112	R:R:I248	R:R:S162	6.19	No	No	0	8	9
113	R:R:S162	R:R:Y252	10.17	No	Yes	0	9	9
114	R:R:I247	R:R:V163	3.07	No	No	0	7	6
115	R:R:D164	R:R:R179	8.34	No	No	0	8	6
116	R:R:R165	R:R:Y252	5.14	No	Yes	1	9	9
117	R:R:R165	R:R:Y336	8.23	No	Yes	1	9	9
118	R:R:C170	R:R:Y166	6.72	No	Yes	9	7	8
119	R:R:H171	R:R:Y166	5.44	Yes	Yes	9	6	8
120	R:R:C251	R:R:Y166	6.72	No	Yes	0	7	8
121	R:R:L254	R:R:Y166	7.03	No	Yes	0	4	8
122	R:R:A168	R:R:R179	5.53	No	No	0	8	6
123	R:R:M255	R:R:V169	7.61	No	No	0	8	8
124	R:R:C170	R:R:H171	4.42	No	Yes	9	7	6
125	R:R:C170	R:R:R258	2.79	No	No	0	7	5
126	R:R:A175	R:R:R179	4.15	No	No	0	6	6
127	R:R:P181	R:R:T180	3.5	No	No	0	1	7
128	R:R:N183	R:R:T180	8.77	No	No	0	4	7
129	R:R:N191	R:R:V187	2.96	No	No	8	7	5
130	R:R:N188	R:R:W192	9.04	No	Yes	3	7	9
131	R:R:L200	R:R:S196	4.5	No	No	0	3	3
132	R:R:L219	R:R:M205	4.24	No	No	0	5	4
133	R:R:F221	R:R:M205	3.73	Yes	No	0	5	4
134	R:R:T207	R:R:T220	4.71	No	No	0	5	4
135	R:R:T208	R:R:Y210	3.75	No	No	0	5	1
136	R:R:D216	R:R:K209	4.15	No	No	0	4	3
137	R:R:K209	R:R:T220	4.5	No	No	0	3	4
138	R:R:R211	R:R:S214	7.91	No	No	0	3	2
139	R:R:D216	R:R:T218	5.78	No	No	0	4	3
140	R:R:F221	R:R:W228	3.01	Yes	No	0	5	3
141	R:R:E229	R:R:F221	5.83	No	Yes	0	4	5
142	R:R:H223	R:R:P224	4.58	No	No	0	4	1
143	R:R:P224	R:R:W228	5.4	No	No	0	1	3
144	R:R:T225	R:R:W226	6.06	No	No	0	3	2
145	R:R:W228	R:R:Y227	3.86	No	No	0	3	3
146	R:R:E229	R:R:K233	5.4	No	No	0	4	4
147	R:R:A304	R:R:K233	3.21	No	No	0	4	4
148	R:R:F237	R:R:I238	3.77	No	No	0	5	4
149	R:R:F237	R:R:I242	3.77	No	No	0	5	5
150	R:R:F237	R:R:H297	4.53	No	Yes	0	5	8
151	R:R:F239	R:R:I238	3.77	No	No	0	4	4
152	R:R:A240	R:R:H297	2.93	No	Yes	0	6	8
153	R:R:F241	R:R:T294	9.08	No	No	0	8	5
154	R:R:F241	R:R:H297	11.31	No	Yes	0	8	8
155	R:R:M243	R:R:P244	6.71	No	No	0	5	9
156	R:R:I290	R:R:V245	4.61	No	No	0	5	6
157	R:R:V282	R:R:Y252	6.31	No	Yes	0	7	9
158	R:R:Y252	R:R:Y336	2.98	Yes	Yes	1	9	9
159	R:R:I256	R:R:T279	6.08	No	No	0	5	6
160	R:R:L259	R:R:V262	2.98	Yes	No	0	8	6
161	R:R:L259	R:R:L265	4.15	Yes	No	0	8	3
162	R:R:L259	R:R:L275	2.77	Yes	No	0	8	6
163	R:R:I278	R:R:L259	2.85	No	Yes	0	7	8
164	R:R:K260	R:R:L275	2.82	No	No	0	4	6
165	R:R:G267	R:R:K271	3.49	No	No	0	3	4
166	R:R:K271	R:R:S268	3.06	No	No	0	4	4
167	R:R:E270	R:R:N274	5.26	No	No	0	2	5
168	R:R:N274	R:R:R277	9.64	No	No	0	5	7
169	R:R:R277	R:R:R280	4.26	No	No	0	7	6
170	R:R:L283	R:R:T279	2.95	No	No	0	4	6
171	R:R:L339	R:R:M281	2.83	No	No	0	6	8
172	R:R:L335	R:R:V285	2.98	No	No	0	8	8
173	R:R:V285	R:R:Y336	5.05	No	Yes	0	8	9
174	R:R:L331	R:R:V288	2.98	No	No	0	7	6
175	R:R:L335	R:R:V288	2.98	No	No	0	8	6
176	R:R:F289	R:R:W293	12.03	No	Yes	6	9	8
177	R:R:I290	R:R:T294	3.04	No	No	0	5	5
178	R:R:C292	R:R:N328	11.02	No	No	0	8	9
179	R:R:N328	R:R:W293	10.17	No	Yes	0	9	8
180	R:R:P295	R:R:T294	3.5	No	No	0	9	5
181	R:R:L324	R:R:P295	3.28	No	No	0	7	9
182	R:R:C321	R:R:I296	3.27	No	No	0	6	6
183	R:R:I296	R:R:I322	2.94	No	No	0	6	5
184	R:R:Q314	R:R:Y299	4.51	No	Yes	0	4	4
185	R:R:S317	R:R:Y299	5.09	No	Yes	0	5	4
186	R:R:W318	R:R:Y299	7.72	Yes	Yes	0	5	4
187	R:R:C321	R:R:Y299	4.03	No	Yes	0	6	4
188	R:R:I302	R:R:I306	2.94	No	No	0	5	3
189	R:R:I308	R:R:K303	2.91	No	No	0	1	4
190	R:R:K303	R:R:W318	6.96	No	Yes	0	4	5
191	R:R:I306	R:R:L305	2.85	No	No	0	3	5
192	R:R:I308	R:R:Q314	10.98	No	No	0	1	4
193	R:R:F313	R:R:S317	7.93	No	No	0	2	5
194	R:R:H319	R:R:W318	5.29	Yes	Yes	0	4	5
195	R:R:I322	R:R:W318	7.05	No	Yes	0	5	5
196	R:R:F320	R:R:L324	7.31	No	No	0	5	7
197	R:R:L331	R:R:T327	2.95	No	No	0	7	5
198	R:R:C330	R:R:L331	3.17	No	No	0	7	7
199	R:R:N332	R:R:P333	4.89	Yes	No	1	9	9
200	R:R:N332	R:R:Y336	4.65	Yes	Yes	1	9	9
201	R:R:L335	R:R:V334	2.98	No	No	0	8	6
202	R:R:A337	R:R:F343	4.16	No	Yes	0	7	9
203	R:R:F338	R:R:L339	3.65	No	No	0	6	6
204	R:R:F338	R:R:K344	3.72	No	No	0	6	8
205	R:R:D340	R:R:N342	4.04	Yes	No	0	8	6
206	R:R:D340	R:R:F343	3.58	Yes	Yes	0	8	9
207	R:R:F347	R:R:K344	4.96	No	No	0	6	8
208	R:R:C346	R:R:F347	2.79	No	No	0	5	6
209	L:L:?1	R:R:V143	2.72	Yes	No	0	0	5
210	R:R:C346	R:R:Y96	2.69	No	No	0	5	5
211	R:R:A184	R:R:Y106	2.67	No	Yes	0	7	7
212	R:R:F135	R:R:V126	2.62	Yes	No	0	7	5
213	R:R:F152	R:R:V236	2.62	Yes	No	0	7	5
214	R:R:H171	R:R:K174	2.62	Yes	No	0	6	4
215	R:R:F221	R:R:T225	2.59	Yes	No	0	5	3
216	R:R:V286	R:R:Y252	2.52	No	Yes	0	8	9
217	R:R:F178	R:R:I167	2.51	No	No	0	4	5
218	R:R:F178	R:R:K174	2.48	No	No	0	4	4
219	R:R:V300	R:R:W318	2.45	No	Yes	0	5	5
220	R:R:M255	R:R:Y252	2.39	No	Yes	0	8	9
221	R:R:I215	R:R:W133	2.35	No	Yes	0	4	8
222	R:R:G199	R:R:P201	2.03	No	No	0	7	7
223	R:R:C330	R:R:G82	1.96	No	No	0	7	8
224	R:R:G131	R:R:T132	1.82	No	No	0	4	5
225	R:R:A102	R:R:A184	1.79	No	No	0	6	7
226	R:R:P172	R:R:V173	1.77	No	No	0	7	5
227	R:R:G199	R:R:I198	1.76	No	No	0	7	4
228	R:R:P134	R:R:T132	1.75	No	No	0	4	5
229	R:R:P309	R:R:T307	1.75	No	No	0	3	3
230	R:R:A73	R:R:S76	1.71	No	No	0	5	4
231	R:R:G85	R:R:L88	1.71	No	No	0	7	6
232	R:R:C251	R:R:V163	1.71	No	No	0	7	6
233	R:R:A111	R:R:V89	1.7	No	No	0	9	9
234	R:R:A206	R:R:V202	1.7	No	No	0	4	5
235	R:R:G325	R:R:N328	1.7	No	No	0	7	9
236	R:R:I308	R:R:P309	1.69	No	No	0	1	3
237	R:R:A68	R:R:T67	1.68	No	No	0	4	3
238	R:R:G213	R:R:Q212	1.64	No	No	0	3	5
239	R:R:A206	R:R:K141	1.61	No	Yes	0	4	6
240	R:R:S119	R:R:T120	1.6	No	No	0	5	6
241	R:R:S214	R:R:T132	1.6	No	No	0	2	5
242	R:R:V284	R:R:V288	1.6	No	No	0	6	6
243	R:R:T67	R:R:V316	1.59	No	No	0	3	1
244	R:R:T249	R:R:V250	1.59	No	No	0	4	4
245	R:R:T315	R:R:V316	1.59	No	No	0	4	1
246	R:R:A323	R:R:L74	1.58	No	No	0	4	5
247	R:R:T311	R:R:T312	1.57	No	No	0	1	4
248	R:R:I193	R:R:V189	1.54	No	No	0	4	4
249	R:R:M72	R:R:S76	1.53	No	No	0	5	4
250	R:R:H171	R:R:P172	1.53	Yes	No	0	6	7
251	R:R:K269	R:R:S268	1.53	No	No	0	1	4
252	R:R:M264	R:R:V262	1.52	No	No	0	5	6
253	R:R:M281	R:R:V284	1.52	No	No	0	8	6
254	R:R:F84	R:R:G85	1.51	No	No	0	4	7
255	R:R:L74	R:R:V78	1.49	No	No	0	5	7
256	R:R:L88	R:R:V92	1.49	No	No	0	6	7
257	R:R:L259	R:R:V169	1.49	Yes	No	0	8	8
258	R:R:I234	R:R:I238	1.47	No	No	0	4	4
259	R:R:I256	R:R:I278	1.47	No	No	0	5	7
260	R:R:I298	R:R:I302	1.47	No	No	0	6	5
261	R:R:I69	R:R:M65	1.46	No	No	0	4	2
262	R:R:I105	R:R:M99	1.46	No	No	0	6	7
263	R:R:I138	R:R:K141	1.45	No	Yes	0	2	6
264	R:R:I242	R:R:L246	1.43	No	No	0	5	3
265	R:R:I105	R:R:N188	1.42	No	No	0	6	7
266	R:R:G136	R:R:W133	1.41	No	Yes	0	7	8
267	R:R:L265	R:R:N274	1.37	No	No	0	3	5
268	R:R:D177	R:R:L176	1.36	No	No	0	4	5
269	R:R:D340	R:R:E341	1.3	Yes	No	0	8	4
270	R:R:E310	R:R:Q314	1.27	No	No	0	1	4
271	R:R:F221	R:R:L232	1.22	Yes	No	0	5	5
272	R:R:D177	R:R:F178	1.19	No	No	0	4	4
273	R:R:Q212	R:R:R211	1.17	No	No	0	5	3
274	R:R:F347	R:R:R348	1.07	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.96667	9	0	0
2	R:R:Y75	7.355	4	2	7
3	R:R:I93	3.544	5	7	7
4	R:R:Y106	4.8875	4	0	7
5	R:R:F108	5.035	4	7	6
6	R:R:L121	7.352	5	2	7
7	R:R:Q124	6.24	4	2	6
8	R:R:Y128	7.9175	4	2	5
9	R:R:W133	8.20333	6	5	8
10	R:R:F135	8.548	5	0	7
11	R:R:K141	3.186	5	0	6
12	R:R:Y149	5.692	5	3	4
13	R:R:N150	6.5225	4	3	8
14	R:R:F152	3.63	4	0	7
15	R:R:T153	4.978	5	3	7
16	R:R:Y166	6.4775	4	9	8
17	R:R:H171	3.5025	4	9	6
18	R:R:W192	8.75	4	3	9
19	R:R:F221	3.276	5	0	5
20	R:R:Y252	4.91833	6	1	9
21	R:R:L259	2.848	5	0	8
22	R:R:W293	8.8	4	6	8
23	R:R:H297	6.1575	4	0	8
24	R:R:Y299	5.3375	4	0	4
25	R:R:W318	5.894	5	0	5
26	R:R:H319	7.7875	4	2	4
27	R:R:Y326	6.1775	4	2	7
28	R:R:N332	6.16	4	1	9
29	R:R:Y336	4.87	6	1	9
30	R:R:D340	2.93	4	0	8
31	R:R:F343	4.1725	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q124	67.583	13.34	Yes	Yes	0	0	6
2	R:R:L121	R:R:Q124	60.5682	3.99	Yes	Yes	2	7	6
3	R:R:L121	R:R:Y75	52.9098	10.55	Yes	Yes	2	7	7
4	R:R:I71	R:R:Y75	12.2874	10.88	No	Yes	2	4	7
5	R:R:I71	R:R:Y128	11.1979	12.09	No	Yes	2	4	5
6	R:R:H319	R:R:Y75	24.3955	4.36	Yes	Yes	2	4	7
7	R:R:H319	R:R:Y128	11.9013	10.89	Yes	Yes	2	4	5
8	R:R:L129	R:R:Y128	11.7404	4.69	No	Yes	0	5	5
9	L:L:?1	R:R:H297	99.0255	5.86	Yes	Yes	0	0	8
10	R:R:A240	R:R:H297	100	2.93	No	Yes	0	6	8
11	R:R:A240	R:R:F152	99.9954	2.77	No	Yes	0	6	7
12	R:R:F152	R:R:F156	99.7794	5.36	Yes	No	0	7	6
13	R:R:F156	R:R:N191	45.2377	4.83	No	No	0	6	7
14	R:R:N191	R:R:T160	43.3667	7.31	No	No	8	7	7
15	R:R:T160	R:R:Y106	42.8427	7.49	No	Yes	0	7	7
16	R:R:M161	R:R:Y106	38.0482	4.79	No	Yes	0	8	7
17	R:R:M161	R:R:Y336	37.5701	4.79	No	Yes	0	8	9
18	R:R:N332	R:R:Y336	15.6431	4.65	Yes	Yes	1	9	9
19	R:R:F156	R:R:S195	61.8691	3.96	No	No	0	6	8
20	R:R:S195	R:R:Y149	31.061	3.82	No	Yes	3	8	4
21	R:R:W192	R:R:Y149	28.7441	8.68	Yes	Yes	3	9	4
22	R:R:N188	R:R:W192	47.1867	9.04	No	Yes	3	7	9
23	R:R:I105	R:R:N188	53.7143	1.42	No	No	0	6	7
24	R:R:I105	R:R:M99	50.239	1.46	No	No	0	6	7
25	R:R:I93	R:R:M99	40.9856	2.92	Yes	No	7	7	7
26	R:R:S195	R:R:T153	30.2841	4.8	No	Yes	3	8	7
27	R:R:T153	R:R:W192	28.3534	4.85	Yes	Yes	3	7	9
28	R:R:F343	R:R:I93	17.2106	5.02	Yes	Yes	0	9	7
29	R:R:I107	R:R:I93	19.1413	2.94	No	Yes	0	8	7
30	R:R:V285	R:R:Y336	19.9136	5.05	No	Yes	0	8	9
31	R:R:L335	R:R:V285	18.9758	2.98	No	No	0	8	8
32	R:R:L335	R:R:V288	16.8705	2.98	No	No	0	8	6
33	R:R:V284	R:R:V288	11.4462	1.6	No	No	0	6	6
34	R:R:M281	R:R:V284	10.3337	1.52	No	No	0	8	6
35	R:R:I107	R:R:T103	11.8829	3.04	No	No	0	8	8
36	R:R:N109	R:R:T157	15.5833	5.85	No	No	0	9	7
37	R:R:L110	R:R:T157	14.2089	4.42	No	No	0	9	7
38	L:L:?1	R:R:C217	22.4648	5.79	Yes	No	0	0	9
39	R:R:C217	R:R:W133	20.3043	7.84	No	Yes	5	9	8
40	R:R:F135	R:R:W133	16.682	22.05	Yes	Yes	0	7	8
41	L:L:?1	R:R:I144	19.1275	5.2	Yes	No	0	0	5
42	R:R:A206	R:R:I144	18.1438	4.87	No	No	0	4	5
43	R:R:A206	R:R:K141	15.6615	1.61	No	Yes	0	4	6
44	L:L:?1	R:R:W293	29.8198	8.3	Yes	Yes	0	0	8
45	R:R:I155	R:R:W293	23.991	4.7	No	Yes	6	8	8
46	R:R:I155	R:R:P244	22.8877	3.39	No	No	0	8	9
47	R:R:C159	R:R:P244	20.479	3.77	No	No	0	7	9
48	R:R:C159	R:R:I247	19.2608	3.27	No	No	0	7	7
49	R:R:Y252	R:R:Y336	22.6855	2.98	Yes	Yes	1	9	9
50	R:R:I247	R:R:V163	18.0335	3.07	No	No	0	7	6
51	R:R:C251	R:R:V163	16.7969	1.71	No	No	0	7	6
52	R:R:C251	R:R:Y166	15.5512	6.72	No	Yes	0	7	8
53	R:R:H171	R:R:Y166	10.513	5.44	Yes	Yes	9	6	8
54	R:R:M255	R:R:Y252	17.7898	2.39	No	Yes	0	8	9
55	R:R:M255	R:R:V169	16.728	7.61	No	No	0	8	8
56	R:R:L259	R:R:V169	15.7534	1.49	Yes	No	0	8	8
57	R:R:I322	R:R:Y75	15.6707	3.63	No	Yes	0	5	7
58	R:R:H319	R:R:W318	12.8344	5.29	Yes	Yes	0	4	5
59	R:R:W318	R:R:Y299	11.4967	7.72	Yes	Yes	0	5	4
60	R:R:I322	R:R:W318	12.3334	7.05	No	Yes	0	5	5
61	R:R:L110	R:R:N332	11.4783	10.98	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q124	13.34	0	Yes	Yes	0	6	0	1
L:L:?1	R:R:I144	5.2	0	Yes	No	0	5	0	1
L:L:?1	R:R:D147	14.84	0	Yes	No	0	6	0	1
L:L:?1	R:R:Y148	11.75	0	Yes	No	0	4	0	1
L:L:?1	R:R:M151	21.9	0	Yes	No	0	7	0	1
L:L:?1	R:R:C217	5.79	0	Yes	No	0	9	0	1
L:L:?1	R:R:W293	8.3	0	Yes	Yes	0	8	0	1
L:L:?1	R:R:H297	5.86	0	Yes	Yes	0	8	0	1
R:R:Q124	R:R:T120	4.25	2	Yes	No	6	6	1	2
R:R:L121	R:R:Q124	3.99	2	Yes	Yes	7	6	2	1
R:R:L121	R:R:Y326	12.89	2	Yes	Yes	7	7	2	2
R:R:Q124	R:R:Y326	3.38	2	Yes	Yes	6	7	1	2
R:R:C140	R:R:W133	6.53	5	No	Yes	9	8	2	2
R:R:C217	R:R:W133	7.84	5	No	Yes	9	8	1	2
R:R:C140	R:R:I144	3.27	5	No	No	9	5	2	1
R:R:C140	R:R:C217	5.46	5	No	No	9	9	2	1
R:R:A206	R:R:I144	4.87	0	No	No	4	5	2	1
R:R:D147	R:R:Y326	3.45	0	No	Yes	6	7	1	2
R:R:F289	R:R:I155	3.77	6	No	No	9	8	2	2
R:R:I155	R:R:W293	4.7	6	No	Yes	8	8	2	1
R:R:F237	R:R:H297	4.53	0	No	Yes	5	8	2	1
R:R:A240	R:R:H297	2.93	0	No	Yes	6	8	2	1
R:R:F241	R:R:H297	11.31	0	No	Yes	8	8	2	1
R:R:F289	R:R:W293	12.03	6	No	Yes	9	8	2	1
R:R:N328	R:R:W293	10.17	0	No	Yes	9	8	2	1
L:L:?1	R:R:V143	2.72	0	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BQJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	258
Number of Links	274
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	9
Number of Nodes involved in Communities	41
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	38220
Length Of Smallest Path	3
Average Path Length	14.6717
Length of Longest Path	35
Minimum Path Strength	1.275
Average Path Strength	5.31723
Maximum Path Strength	18.37
Minimum Path Correlation	0.7
Average Path Correlation	0.925227
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	46.8382
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3568
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • neuropeptide binding • peptide binding • G-protein alpha-subunit binding • peptide receptor activity • molecular transducer activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • protein domain specific binding • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • G protein-coupled opioid receptor signaling pathway • multi-multicellular organism process • multicellular organismal process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • positive regulation of biological process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • positive regulation of cellular process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • neuropeptide signaling pathway • monosaccharide metabolic process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • locomotory behavior • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of transport • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of hormone levels • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • secretion • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • eating behavior • feeding behavior • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • adenylate cyclase-inhibiting opioid receptor signaling pathway • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • regulation of nitric oxide metabolic process • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • adult behavior • behavioral response to ethanol • response to ethanol • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • biological process involved in intraspecies interaction between organisms • social behavior • sensory perception • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • regulation of protein localization • negative regulation of Wnt protein secretion • protein localization to extracellular region • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • establishment of protein localization to extracellular region • regulation of establishment of protein localization • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • negative regulation of protein secretion • protein transport • macromolecule localization • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • dendrite • dendritic tree • endomembrane system • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • axon • mitochondrion • anchoring junction • focal adhesion • cell-substrate junction • GABA-ergic synapse • neuron projection cytoplasm • dendrite cytoplasm • cell leading edge • leading edge membrane • neuron projection membrane • dendrite membrane • cell projection membrane • endosome • intracellular vesicle • cytoplasmic vesicle • neuron spine • dendritic spine • spine apparatus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of lipid metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • nitrogen compound transport • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of peptide secretion • negative regulation of peptide secretion • peptide secretion • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>9BQJ_nogp_Chain_R M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

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Download 9BQJ_nogp.zip

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