psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T67	R:R:V316	3.17	No	No	0	3	1
2	R:R:A68	R:R:Y128	4	No	Yes	0	4	5
3	R:R:I71	R:R:Y128	20.55	No	Yes	3	4	5
4	R:R:H319	R:R:I71	9.28	Yes	No	3	4	4
5	R:R:L129	R:R:M72	4.24	No	No	0	5	5
6	R:R:F320	R:R:L74	4.87	No	No	0	5	5
7	R:R:A323	R:R:L74	4.73	No	No	0	4	5
8	R:R:L121	R:R:Y75	7.03	Yes	No	0	7	7
9	R:R:H319	R:R:Y75	10.89	Yes	No	0	4	7
10	R:R:I322	R:R:Y75	4.84	Yes	No	0	5	7
11	R:R:L121	R:R:V78	2.98	Yes	No	0	7	7
12	R:R:C79	R:R:P122	3.77	No	No	0	6	8
13	R:R:C330	R:R:V81	3.42	No	No	0	7	5
14	R:R:L83	R:R:T118	2.95	No	No	0	6	6
15	R:R:F84	R:R:G85	3.01	No	No	0	4	7
16	R:R:D114	R:R:N86	6.73	Yes	No	0	9	9
17	R:R:N86	R:R:P333	4.89	No	No	0	9	9
18	R:R:F87	R:R:M90	4.98	No	Yes	0	4	7
19	R:R:L88	R:R:V92	2.98	No	No	0	6	7
20	R:R:A111	R:R:V89	3.39	No	No	0	9	9
21	R:R:P333	R:R:V89	3.53	No	No	0	9	9
22	R:R:F108	R:R:M90	7.46	Yes	Yes	0	6	7
23	R:R:A111	R:R:M90	3.22	No	Yes	0	9	7
24	R:R:R95	R:R:Y91	20.58	No	No	0	4	4
25	R:R:F347	R:R:V92	3.93	No	No	0	6	7
26	R:R:I93	R:R:N104	4.25	Yes	No	0	7	8
27	R:R:R95	R:R:Y96	3.09	No	No	0	4	5
28	R:R:F347	R:R:Y96	4.13	No	No	0	6	5
29	R:R:N104	R:R:T97	4.39	No	No	0	8	6
30	R:R:K100	R:R:K98	5.75	No	No	0	6	5
31	R:R:F108	R:R:M99	8.71	Yes	No	0	6	7
32	R:R:N104	R:R:T101	4.39	No	No	0	8	8
33	R:R:I107	R:R:T103	3.04	No	No	0	8	8
34	R:R:I105	R:R:K185	4.36	No	No	0	6	2
35	R:R:I105	R:R:N188	4.25	No	No	0	6	7
36	R:R:T160	R:R:Y106	7.49	No	Yes	5	7	7
37	R:R:M161	R:R:Y106	4.79	No	Yes	0	8	7
38	R:R:D164	R:R:Y106	3.45	No	Yes	0	8	7
39	R:R:A184	R:R:Y106	2.67	No	Yes	0	7	7
40	R:R:V187	R:R:Y106	3.79	No	Yes	5	5	7
41	R:R:N188	R:R:Y106	8.14	No	Yes	0	7	7
42	R:R:F108	R:R:N109	6.04	Yes	No	0	6	9
43	R:R:N109	R:R:N188	10.9	No	No	0	9	7
44	R:R:D114	R:R:L110	6.79	Yes	No	4	9	9
45	R:R:L110	R:R:T157	2.95	No	No	0	9	7
46	R:R:L110	R:R:N332	8.24	No	No	4	9	9
47	R:R:D114	R:R:S154	4.42	Yes	No	0	9	9
48	R:R:D114	R:R:S329	11.78	Yes	No	0	9	9
49	R:R:D114	R:R:N332	6.73	Yes	No	4	9	9
50	R:R:L116	R:R:N150	5.49	No	Yes	0	7	8
51	R:R:A117	R:R:N150	4.69	No	Yes	0	7	8
52	L:L:?1	R:R:A117	3.96	Yes	No	0	0	7
53	R:R:L121	R:R:P122	3.28	Yes	No	0	7	8
54	R:R:L121	R:R:Y326	3.52	Yes	Yes	0	7	7
55	R:R:F123	R:R:F135	3.22	No	Yes	0	6	7
56	R:R:F123	R:R:V143	6.55	No	No	0	6	5
57	R:R:Q124	R:R:Y326	5.64	No	Yes	1	6	7
58	L:L:?1	R:R:Q124	15.61	Yes	No	1	0	6
59	R:R:F135	R:R:V126	2.62	Yes	No	0	7	5
60	R:R:N127	R:R:W133	7.91	No	Yes	0	6	8
61	R:R:H319	R:R:Y128	3.27	Yes	Yes	3	4	5
62	R:R:S214	R:R:T132	9.59	No	No	0	2	5
63	R:R:P134	R:R:W133	4.05	No	Yes	2	4	8
64	R:R:F135	R:R:W133	13.03	Yes	Yes	2	7	8
65	R:R:C140	R:R:W133	6.53	No	Yes	2	9	8
66	R:R:C217	R:R:W133	7.84	No	Yes	2	9	8
67	R:R:F135	R:R:P134	7.22	Yes	No	2	7	4
68	R:R:F135	R:R:L139	7.31	Yes	No	0	7	6
69	R:R:K141	R:R:N137	8.39	No	No	0	6	1
70	R:R:N137	R:R:T208	4.39	No	No	0	1	5
71	R:R:C140	R:R:T208	3.38	No	No	0	9	5
72	R:R:C140	R:R:C217	5.46	No	No	2	9	9
73	R:R:K141	R:R:M203	7.2	No	No	0	6	4
74	R:R:I142	R:R:M203	2.92	No	No	0	5	4
75	R:R:C217	R:R:I144	3.27	No	No	0	9	5
76	R:R:I144	R:R:L219	2.85	No	No	0	5	5
77	L:L:?1	R:R:I144	8.37	Yes	No	0	0	5
78	R:R:S145	R:R:V202	3.23	No	No	0	6	5
79	R:R:M203	R:R:S145	6.13	No	No	0	4	6
80	R:R:I146	R:R:N150	4.25	No	Yes	0	5	8
81	R:R:D147	R:R:Y326	5.75	No	Yes	1	6	7
82	L:L:?1	R:R:D147	9.09	Yes	No	1	0	6
83	L:L:?1	R:R:Y148	10.8	Yes	No	0	0	4
84	R:R:N150	R:R:Y149	3.49	Yes	Yes	0	8	4
85	R:R:W192	R:R:Y149	5.79	No	Yes	0	9	4
86	R:R:S195	R:R:Y149	5.09	No	Yes	0	8	4
87	R:R:S196	R:R:Y149	8.9	No	Yes	0	3	4
88	R:R:G199	R:R:Y149	5.79	No	Yes	0	7	4
89	R:R:F152	R:R:M151	6.22	Yes	No	0	7	7
90	R:R:M151	R:R:W293	4.65	No	Yes	1	7	8
91	L:L:?1	R:R:M151	5.92	Yes	No	1	0	7
92	R:R:F152	R:R:S195	2.64	Yes	No	0	7	8
93	R:R:F152	R:R:I198	3.77	Yes	No	0	7	4
94	R:R:F152	R:R:V236	2.62	Yes	No	0	7	5
95	R:R:A240	R:R:F152	2.77	No	Yes	0	6	7
96	R:R:T153	R:R:W192	14.55	No	No	0	7	9
97	R:R:S195	R:R:T153	6.4	No	No	0	8	7
98	R:R:I155	R:R:P244	3.39	No	No	0	8	9
99	R:R:I155	R:R:W293	4.7	No	Yes	0	8	8
100	R:R:F156	R:R:N191	6.04	No	No	0	6	7
101	R:R:N191	R:R:T157	2.92	No	No	0	7	7
102	R:R:L158	R:R:Y336	4.69	No	Yes	0	8	9
103	R:R:C159	R:R:P244	3.77	No	No	0	7	9
104	R:R:C159	R:R:I247	6.55	No	No	0	7	7
105	R:R:T160	R:R:V187	3.17	No	No	5	7	5
106	R:R:M161	R:R:Y336	7.18	No	Yes	0	8	9
107	R:R:I248	R:R:S162	6.19	No	No	0	8	9
108	R:R:S162	R:R:Y252	10.17	No	Yes	0	9	9
109	R:R:D164	R:R:R179	13.1	No	Yes	0	8	6
110	R:R:R165	R:R:Y252	8.23	No	Yes	0	9	9
111	R:R:R165	R:R:Y336	5.14	No	Yes	0	9	9
112	R:R:I167	R:R:Y166	3.63	No	Yes	0	5	8
113	R:R:C170	R:R:Y166	9.41	No	Yes	6	7	8
114	R:R:H171	R:R:Y166	5.44	No	Yes	6	6	8
115	R:R:C251	R:R:Y166	2.69	No	Yes	0	7	8
116	R:R:A168	R:R:R179	5.53	No	Yes	0	8	6
117	R:R:M255	R:R:V169	3.04	No	No	0	8	8
118	R:R:C170	R:R:H171	2.95	No	No	6	7	6
119	R:R:K174	R:R:V173	3.04	No	No	0	4	5
120	R:R:A175	R:R:R179	2.77	No	Yes	0	6	6
121	R:R:N183	R:R:T180	5.85	No	No	0	4	7
122	R:R:L200	R:R:S196	3	No	No	0	3	3
123	R:R:L219	R:R:V202	4.47	No	No	0	5	5
124	R:R:K209	R:R:T207	3	No	No	7	3	5
125	R:R:T207	R:R:T220	3.14	No	No	7	5	4
126	R:R:I215	R:R:T208	4.56	No	No	0	4	5
127	R:R:K209	R:R:T218	7.51	No	No	0	3	3
128	R:R:K209	R:R:T220	6.01	No	No	7	3	4
129	R:R:I215	R:R:Y210	21.76	No	No	0	4	1
130	R:R:D216	R:R:R211	4.76	No	No	0	4	3
131	R:R:D216	R:R:T218	4.34	No	No	0	4	3
132	R:R:E229	R:R:F221	11.66	No	No	0	4	5
133	R:R:F221	R:R:L232	3.65	No	No	0	5	5
134	R:R:P224	R:R:S222	5.34	No	No	0	1	6
135	R:R:S222	R:R:W228	11.12	No	No	0	6	3
136	R:R:H223	R:R:P224	6.1	No	No	0	4	1
137	R:R:P224	R:R:W226	2.7	No	No	0	1	2
138	R:R:E229	R:R:T225	7.06	No	No	0	4	3
139	R:R:W226	R:R:Y227	4.82	No	No	0	2	3
140	R:R:W228	R:R:Y227	5.79	No	No	0	3	3
141	R:R:A304	R:R:K233	3.21	No	No	0	4	4
142	R:R:F237	R:R:H297	5.66	No	Yes	0	5	8
143	R:R:F239	R:R:I238	5.02	No	No	0	4	4
144	R:R:F241	R:R:V245	3.93	Yes	Yes	0	8	6
145	R:R:F241	R:R:T294	6.49	Yes	No	0	8	5
146	R:R:F241	R:R:H297	9.05	Yes	Yes	0	8	8
147	R:R:I242	R:R:M243	2.92	Yes	No	0	5	5
148	R:R:F289	R:R:P244	2.89	Yes	No	0	9	9
149	R:R:F289	R:R:V245	2.62	Yes	Yes	0	9	6
150	R:R:I290	R:R:V245	4.61	No	Yes	0	5	6
151	R:R:I248	R:R:V286	3.07	No	No	0	8	8
152	R:R:F289	R:R:I248	3.77	Yes	No	0	9	8
153	R:R:L254	R:R:V250	2.98	No	No	0	4	4
154	R:R:M255	R:R:Y252	4.79	No	Yes	0	8	9
155	R:R:V282	R:R:Y252	7.57	No	Yes	0	7	9
156	R:R:L259	R:R:M255	2.83	Yes	No	0	8	8
157	R:R:I256	R:R:T279	3.04	No	No	0	5	6
158	R:R:R258	R:R:S261	2.64	No	No	0	5	4
159	R:R:K260	R:R:L275	2.82	No	No	0	4	6
160	R:R:K271	R:R:S268	7.65	No	No	0	4	4
161	R:R:E270	R:R:R273	19.77	No	No	0	2	4
162	R:R:V285	R:R:Y336	8.83	No	Yes	0	8	9
163	R:R:L335	R:R:V288	4.47	No	Yes	0	8	6
164	R:R:F289	R:R:W293	6.01	Yes	Yes	0	9	8
165	R:R:I290	R:R:T294	3.04	No	No	0	5	5
166	R:R:C292	R:R:T327	3.38	No	No	0	8	5
167	R:R:H297	R:R:W293	4.23	Yes	Yes	1	8	8
168	R:R:N328	R:R:W293	9.04	No	Yes	0	9	8
169	L:L:?1	R:R:W293	10.49	Yes	Yes	1	0	8
170	R:R:L324	R:R:P295	4.93	No	No	0	7	9
171	R:R:H297	R:R:I296	2.65	Yes	Yes	0	8	6
172	R:R:I296	R:R:V300	3.07	Yes	No	0	6	5
173	R:R:C321	R:R:I296	4.91	No	Yes	0	6	6
174	R:R:I296	R:R:I322	4.42	Yes	Yes	0	6	5
175	L:L:?1	R:R:H297	5.38	Yes	Yes	1	0	8
176	R:R:Q314	R:R:Y299	5.64	Yes	No	8	4	4
177	R:R:S317	R:R:Y299	3.82	No	No	8	5	4
178	R:R:W318	R:R:Y299	9.65	Yes	No	0	5	4
179	R:R:K303	R:R:W318	10.44	No	Yes	0	4	5
180	R:R:I306	R:R:I308	2.94	No	No	0	3	1
181	R:R:I308	R:R:Q314	6.86	No	Yes	0	1	4
182	R:R:Q314	R:R:T311	2.83	Yes	No	0	4	1
183	R:R:F313	R:R:S317	2.64	No	No	0	2	5
184	R:R:Q314	R:R:S317	2.89	Yes	No	8	4	5
185	R:R:H319	R:R:W318	8.46	Yes	Yes	0	4	5
186	R:R:I322	R:R:W318	4.7	Yes	Yes	0	5	5
187	L:L:?1	R:R:I322	3.59	Yes	Yes	0	0	5
188	L:L:?1	R:R:Y326	14.73	Yes	Yes	1	0	7
189	R:R:N328	R:R:N332	5.45	No	No	0	9	9
190	L:L:?1	R:R:S329	5.03	Yes	No	0	0	9
191	R:R:A337	R:R:F343	5.55	No	Yes	0	7	9
192	R:R:K344	R:R:L339	5.64	No	No	0	8	6
193	R:R:D340	R:R:N342	5.39	No	No	0	8	6
194	R:R:D340	R:R:F343	9.55	No	Yes	0	8	9
195	R:R:N342	R:R:R345	4.82	No	No	0	6	4
196	R:R:A113	R:R:W192	2.59	No	No	0	8	9
197	R:R:F108	R:R:I93	2.51	Yes	Yes	0	6	7
198	R:R:F343	R:R:I93	2.51	Yes	Yes	0	9	7
199	R:R:F237	R:R:I242	2.51	No	Yes	0	5	5
200	R:R:F241	R:R:I242	2.51	Yes	Yes	0	8	5
201	R:R:F87	R:R:L83	2.44	No	No	0	4	6
202	R:R:F108	R:R:L112	2.44	Yes	No	0	6	6
203	R:R:N274	R:R:R277	2.41	No	No	0	5	7
204	R:R:M72	R:R:Y128	2.39	No	Yes	0	5	5
205	R:R:L232	R:R:Y148	2.34	No	No	0	5	4
206	R:R:C330	R:R:G82	1.96	No	No	0	7	8
207	R:R:C321	R:R:P295	1.88	No	No	0	6	9
208	R:R:G213	R:R:S214	1.86	No	No	0	3	2
209	R:R:G82	R:R:T118	1.82	No	No	0	8	6
210	R:R:G131	R:R:T132	1.82	No	No	0	4	5
211	R:R:A102	R:R:A184	1.79	No	No	0	6	7
212	R:R:P122	R:R:S125	1.78	No	No	0	8	6
213	R:R:G131	R:R:M130	1.75	No	No	0	4	3
214	R:R:P181	R:R:T180	1.75	No	No	0	1	7
215	R:R:P309	R:R:T307	1.75	No	No	0	3	3
216	R:R:A73	R:R:S76	1.71	No	No	0	5	4
217	R:R:C251	R:R:V163	1.71	No	No	0	7	6
218	R:R:C292	R:R:V288	1.71	No	Yes	0	8	6
219	R:R:A323	R:R:V78	1.7	No	No	0	4	7
220	R:R:I308	R:R:P309	1.69	No	No	0	1	3
221	R:R:M205	R:R:P201	1.68	No	No	0	4	7
222	R:R:L200	R:R:P201	1.64	No	No	0	3	7
223	R:R:G213	R:R:Q212	1.64	No	No	0	3	5
224	R:R:A337	R:R:I107	1.62	No	No	0	7	8
225	R:R:A175	R:R:I167	1.62	No	No	0	6	5
226	R:R:A68	R:R:M65	1.61	No	No	0	4	2
227	R:R:A115	R:R:M90	1.61	No	Yes	0	7	7
228	R:R:A206	R:R:K141	1.61	No	No	0	4	6
229	R:R:S119	R:R:T120	1.6	No	No	0	5	6
230	R:R:V284	R:R:V288	1.6	No	Yes	0	6	6
231	R:R:T120	R:R:V143	1.59	No	No	0	6	5
232	R:R:T249	R:R:V245	1.59	No	Yes	0	4	6
233	R:R:T249	R:R:V286	1.59	No	No	0	4	8
234	R:R:T315	R:R:V316	1.59	No	No	0	4	1
235	R:R:A304	R:R:L305	1.58	No	No	0	4	5
236	R:R:T312	R:R:T67	1.57	No	No	0	4	3
237	R:R:C292	R:R:N328	1.57	No	No	0	8	9
238	R:R:T311	R:R:T312	1.57	No	No	0	1	4
239	R:R:T312	R:R:T315	1.57	No	No	0	4	4
240	R:R:I77	R:R:S76	1.55	No	No	0	5	4
241	R:R:I93	R:R:V94	1.54	Yes	No	0	7	3
242	R:R:H171	R:R:P172	1.53	No	No	0	6	7
243	R:R:I71	R:R:T70	1.52	No	No	0	4	4
244	R:R:M130	R:R:V126	1.52	No	No	0	3	5
245	R:R:M264	R:R:V262	1.52	No	No	0	5	6
246	R:R:I298	R:R:T294	1.52	No	No	0	6	5
247	R:R:L259	R:R:V262	1.49	Yes	No	0	8	6
248	R:R:L331	R:R:V288	1.49	No	Yes	0	7	6
249	R:R:I238	R:R:I242	1.47	No	Yes	0	4	5
250	R:R:E270	R:R:S268	1.44	No	No	0	2	4
251	R:R:I278	R:R:L259	1.43	No	Yes	0	7	8
252	R:R:I278	R:R:L265	1.43	No	No	0	7	3
253	R:R:I301	R:R:L305	1.43	No	No	0	6	5
254	L:L:?1	R:R:G325	1.43	Yes	No	0	0	7
255	R:R:L246	R:R:M243	1.41	No	No	0	3	5
256	R:R:C346	R:R:F347	1.4	No	No	0	5	6
257	R:R:L254	R:R:L257	1.38	No	No	0	4	2
258	R:R:L259	R:R:L275	1.38	Yes	No	0	8	6
259	R:R:L265	R:R:N274	1.37	No	No	0	3	5
260	R:R:D272	R:R:L275	1.36	No	No	0	3	6
261	R:R:F221	R:R:S222	1.32	No	No	0	5	6
262	R:R:F343	R:R:V92	1.31	Yes	No	0	9	7
263	R:R:R95	R:R:V94	1.31	No	No	0	4	3
264	R:R:R258	R:R:V169	1.31	No	No	0	5	8
265	R:R:R258	R:R:V262	1.31	No	No	0	5	6
266	R:R:F338	R:R:V334	1.31	No	No	0	6	6
267	R:R:F204	R:R:M205	1.24	No	No	0	5	4
268	R:R:K269	R:R:R276	1.24	No	No	0	1	5
269	R:R:M281	R:R:R277	1.24	No	No	0	8	7
270	R:R:F156	R:R:L194	1.22	No	No	0	6	4
271	R:R:N274	R:R:R273	1.21	No	No	0	5	4
272	R:R:L254	R:R:Y166	1.17	No	Yes	0	4	8
273	R:R:Q212	R:R:R211	1.17	No	No	0	5	3
274	R:R:F178	R:R:R179	1.07	No	Yes	0	4	6
275	R:R:R276	R:R:R280	1.07	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M90	4.3175	4	0	7
2	R:R:I93	2.7025	4	0	7
3	R:R:Y106	5.055	6	5	7
4	R:R:F108	5.432	5	0	6
5	R:R:D114	7.29	5	4	9
6	R:R:L121	4.2025	4	0	7
7	R:R:Y128	7.5525	4	3	5
8	R:R:W133	7.872	5	2	8
9	R:R:F135	6.68	5	2	7
10	R:R:Y149	5.812	5	0	4
11	R:R:N150	4.48	4	0	8
12	R:R:F152	3.604	5	0	7
13	R:R:Y166	4.468	5	6	8
14	R:R:R179	5.6175	4	0	6
15	R:R:F241	5.495	4	0	8
16	R:R:I242	2.3525	4	0	5
17	R:R:V245	3.1875	4	0	6
18	R:R:Y252	7.69	4	0	9
19	R:R:L259	1.7825	4	0	8
20	R:R:V288	2.3175	4	0	6
21	R:R:F289	3.8225	4	0	9
22	R:R:W293	6.52	6	1	8
23	R:R:I296	3.7625	4	0	6
24	R:R:H297	5.394	5	1	8
25	R:R:Q314	4.555	4	8	4
26	R:R:W318	8.3125	4	0	5
27	R:R:H319	7.975	4	3	4
28	R:R:I322	4.3875	4	0	5
29	R:R:Y326	7.41	4	1	7
30	R:R:Y336	6.46	4	0	9
31	R:R:F343	4.73	4	0	9
32	L:L:?1	7.86667	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A68	R:R:Y128	10.6051	4	No	Yes	0	4	5
2	R:R:H319	R:R:Y128	26.0316	3.27	Yes	Yes	3	4	5
3	R:R:H319	R:R:W318	22.5358	8.46	Yes	Yes	0	4	5
4	R:R:W318	R:R:Y299	39.01	9.65	Yes	No	0	5	4
5	R:R:Q314	R:R:Y299	30.8317	5.64	Yes	No	8	4	4
6	R:R:Q314	R:R:T311	17.2974	2.83	Yes	No	0	4	1
7	R:R:T311	R:R:T312	14.4323	1.57	No	No	0	1	4
8	R:R:H319	R:R:I71	10.7013	9.28	Yes	No	3	4	4
9	R:R:M72	R:R:Y128	10.5944	2.39	No	Yes	0	5	5
10	R:R:L121	R:R:V78	11.2358	2.98	Yes	No	0	7	7
11	R:R:H319	R:R:Y75	22.4824	10.89	Yes	No	0	4	7
12	R:R:I322	R:R:Y75	24.3639	4.84	Yes	No	0	5	7
13	R:R:I322	R:R:W318	60.9579	4.7	Yes	Yes	0	5	5
14	R:R:L83	R:R:T118	11.6207	2.95	No	No	0	6	6
15	R:R:F87	R:R:L83	14.4751	2.44	No	No	0	4	6
16	R:R:F87	R:R:M90	17.3081	4.98	No	Yes	0	4	7
17	R:R:A111	R:R:M90	69.4035	3.22	No	Yes	0	9	7
18	R:R:A111	R:R:V89	70.6115	3.39	No	No	0	9	9
19	R:R:P333	R:R:V89	72.2579	3.53	No	No	0	9	9
20	R:R:N86	R:R:P333	74.1287	4.89	No	No	0	9	9
21	R:R:D114	R:R:N86	76.053	6.73	Yes	No	0	9	9
22	R:R:D114	R:R:S329	75.8927	11.78	Yes	No	0	9	9
23	L:L:?1	R:R:S329	77.2611	5.03	Yes	No	0	0	9
24	L:L:?1	R:R:I322	81.4945	3.59	Yes	Yes	0	0	5
25	R:R:F343	R:R:V92	11.5245	1.31	Yes	No	0	9	7
26	R:R:F343	R:R:I93	30.65	2.51	Yes	Yes	0	9	7
27	R:R:F108	R:R:I93	51.9243	2.51	Yes	Yes	0	6	7
28	R:R:F108	R:R:M90	59.3008	7.46	Yes	Yes	0	6	7
29	R:R:I93	R:R:V94	11.3962	1.54	Yes	No	0	7	3
30	R:R:N188	R:R:Y106	28.2339	8.14	No	Yes	0	7	7
31	R:R:M161	R:R:Y106	59.2474	4.79	No	Yes	0	8	7
32	R:R:M161	R:R:Y336	60.6799	7.18	No	Yes	0	8	9
33	R:R:R165	R:R:Y336	64.8706	5.14	No	Yes	0	9	9
34	R:R:R165	R:R:Y252	66.1321	8.23	No	Yes	0	9	9
35	R:R:S162	R:R:Y252	92.4204	10.17	No	Yes	0	9	9
36	R:R:I248	R:R:S162	93.5001	6.19	No	No	0	8	9
37	R:R:F289	R:R:I248	95.0289	3.77	Yes	No	0	9	8
38	R:R:F289	R:R:W293	100	6.01	Yes	Yes	0	9	8
39	L:L:?1	R:R:W293	89.2666	10.49	Yes	Yes	1	0	8
40	R:R:N109	R:R:N188	26.6303	10.9	No	No	0	9	7
41	R:R:F108	R:R:N109	27.9453	6.04	Yes	No	0	6	9
42	R:R:D164	R:R:Y106	39.1063	3.45	No	Yes	0	8	7
43	R:R:D114	R:R:L110	10.7868	6.79	Yes	No	4	9	9
44	R:R:L110	R:R:T157	11.92	2.95	No	No	0	9	7
45	R:R:D114	R:R:N332	10.9258	6.73	Yes	No	4	9	9
46	R:R:N328	R:R:N332	15.4159	5.45	No	No	0	9	9
47	R:R:N328	R:R:W293	27.7635	9.04	No	Yes	0	9	8
48	R:R:A117	R:R:N150	31.4839	4.69	No	Yes	0	7	8
49	L:L:?1	R:R:A117	33.9855	3.96	Yes	No	0	0	7
50	L:L:?1	R:R:Y326	20.2373	14.73	Yes	Yes	1	0	7
51	R:R:F135	R:R:W133	48.6209	13.03	Yes	Yes	2	7	8
52	R:R:C217	R:R:W133	53.7952	7.84	No	Yes	2	9	8
53	R:R:C217	R:R:I144	72.9421	3.27	No	No	0	9	5
54	L:L:?1	R:R:I144	90.5602	8.37	Yes	No	0	0	5
55	R:R:F123	R:R:F135	10.7334	3.22	No	Yes	0	6	7
56	R:R:S214	R:R:T132	24.3318	9.59	No	No	0	2	5
57	R:R:G131	R:R:T132	26.9297	1.82	No	No	0	4	5
58	R:R:G131	R:R:M130	29.5061	1.75	No	No	0	4	3
59	R:R:M130	R:R:V126	32.0611	1.52	No	No	0	3	5
60	R:R:F135	R:R:V126	34.3276	2.62	Yes	No	0	7	5
61	R:R:C140	R:R:C217	17.1798	5.46	No	No	2	9	9
62	R:R:C140	R:R:T208	16.688	3.38	No	No	0	9	5
63	R:R:S145	R:R:V202	12.5615	3.23	No	No	0	6	5
64	R:R:L219	R:R:V202	15.1914	4.47	No	No	0	5	5
65	R:R:I144	R:R:L219	17.5433	2.85	No	No	0	5	5
66	L:L:?1	R:R:Y148	29.1212	10.8	Yes	No	0	0	4
67	R:R:N150	R:R:Y149	24.1073	3.49	Yes	Yes	0	8	4
68	R:R:F152	R:R:S195	14.86	2.64	Yes	No	0	7	8
69	R:R:F152	R:R:M151	25.4223	6.22	Yes	No	0	7	7
70	L:L:?1	R:R:M151	12.3477	5.92	Yes	No	1	0	7
71	R:R:S196	R:R:Y149	17.7357	8.9	No	Yes	0	3	4
72	R:R:I155	R:R:W293	10.2095	4.7	No	Yes	0	8	8
73	R:R:F289	R:R:P244	10.5409	2.89	Yes	No	0	9	9
74	R:R:C159	R:R:P244	11.3855	3.77	No	No	0	7	9
75	R:R:D164	R:R:R179	36.6581	13.1	No	Yes	0	8	6
76	R:R:A175	R:R:I167	26.6089	1.62	No	No	0	6	5
77	R:R:A175	R:R:R179	29.1533	2.77	No	Yes	0	6	6
78	R:R:I167	R:R:Y166	24.0432	3.63	No	Yes	0	5	8
79	R:R:M255	R:R:Y252	48.7706	4.79	No	Yes	0	8	9
80	R:R:L200	R:R:S196	14.2292	3	No	No	0	3	3
81	R:R:D216	R:R:T218	11.022	4.34	No	No	0	4	3
82	R:R:D216	R:R:R211	13.7267	4.76	No	No	0	4	3
83	R:R:Q212	R:R:R211	16.4101	1.17	No	No	0	5	3
84	R:R:G213	R:R:Q212	19.0721	1.64	No	No	0	3	5
85	R:R:G213	R:R:S214	21.7126	1.86	No	No	0	3	2
86	R:R:F221	R:R:L232	24.1929	3.65	No	No	0	5	5
87	R:R:L232	R:R:Y148	26.5127	2.34	No	No	0	5	4
88	R:R:F221	R:R:S222	16.5384	1.32	No	No	0	5	6
89	R:R:F237	R:R:H297	14.8813	5.66	No	Yes	0	5	8
90	R:R:H297	R:R:I296	18.5482	2.65	Yes	Yes	0	8	6
91	R:R:I296	R:R:I322	15.3945	4.42	Yes	Yes	0	6	5
92	L:L:?1	R:R:H297	37.631	5.38	Yes	Yes	1	0	8
93	R:R:I238	R:R:I242	10.8937	1.47	No	Yes	0	4	5
94	R:R:F237	R:R:I242	11.9414	2.51	No	Yes	0	5	5
95	R:R:F241	R:R:I242	15.309	2.51	Yes	Yes	0	8	5
96	R:R:F241	R:R:H297	26.7586	9.05	Yes	Yes	0	8	8
97	R:R:F241	R:R:V245	10.9793	3.93	Yes	Yes	0	8	6
98	R:R:F289	R:R:V245	14.1437	2.62	Yes	Yes	0	9	6
99	R:R:I242	R:R:M243	10.8937	2.92	Yes	No	0	5	5
100	R:R:L259	R:R:M255	38.8497	2.83	Yes	No	0	8	8
101	R:R:N274	R:R:R273	11.0648	1.21	No	No	0	5	4
102	R:R:L265	R:R:N274	19.1469	1.37	No	No	0	3	5
103	R:R:I278	R:R:L265	21.7875	1.43	No	No	0	7	3
104	R:R:I278	R:R:L259	24.118	1.43	No	Yes	0	7	8
105	R:R:C292	R:R:V288	11.1931	1.71	No	Yes	0	8	6
106	R:R:C292	R:R:N328	16.6667	1.57	No	No	0	8	9
107	R:R:C321	R:R:I296	12.1445	4.91	No	Yes	0	6	6
108	R:R:I308	R:R:Q314	11.5031	6.86	No	Yes	0	1	4
109	R:R:L200	R:R:P201	10.7013	1.64	No	No	0	3	7
110	R:R:L121	R:R:Y326	18.2275	3.52	Yes	Yes	0	7	7
111	R:R:M151	R:R:W293	15.7152	4.65	No	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L121	R:R:Y75	7.03	0	Yes	No	7	7	2	2
R:R:I322	R:R:Y75	4.84	0	Yes	No	5	7	1	2
R:R:D114	R:R:S329	11.78	4	Yes	No	9	9	2	1
R:R:A117	R:R:N150	4.69	0	No	Yes	7	8	1	2
L:L:?1	R:R:A117	3.96	1	Yes	No	0	7	0	1
R:R:L121	R:R:Y326	3.52	0	Yes	Yes	7	7	2	1
R:R:Q124	R:R:Y326	5.64	1	No	Yes	6	7	1	1
L:L:?1	R:R:Q124	15.61	1	Yes	No	0	6	0	1
R:R:C217	R:R:I144	3.27	2	No	No	9	5	2	1
R:R:I144	R:R:L219	2.85	0	No	No	5	5	1	2
L:L:?1	R:R:I144	8.37	1	Yes	No	0	5	0	1
R:R:D147	R:R:Y326	5.75	1	No	Yes	6	7	1	1
L:L:?1	R:R:D147	9.09	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y148	10.8	1	Yes	No	0	4	0	1
R:R:F152	R:R:M151	6.22	0	Yes	No	7	7	2	1
R:R:M151	R:R:W293	4.65	1	No	Yes	7	8	1	1
L:L:?1	R:R:M151	5.92	1	Yes	No	0	7	0	1
R:R:I155	R:R:W293	4.7	0	No	Yes	8	8	2	1
R:R:F237	R:R:H297	5.66	0	No	Yes	5	8	2	1
R:R:F241	R:R:H297	9.05	0	Yes	Yes	8	8	2	1
R:R:F289	R:R:W293	6.01	0	Yes	Yes	9	8	2	1
R:R:H297	R:R:W293	4.23	1	Yes	Yes	8	8	1	1
R:R:N328	R:R:W293	9.04	0	No	Yes	9	8	2	1
L:L:?1	R:R:W293	10.49	1	Yes	Yes	0	8	0	1
R:R:H297	R:R:I296	2.65	1	Yes	Yes	8	6	1	2
R:R:I296	R:R:I322	4.42	0	Yes	Yes	6	5	2	1
L:L:?1	R:R:H297	5.38	1	Yes	Yes	0	8	0	1
R:R:I322	R:R:W318	4.7	0	Yes	Yes	5	5	1	2
L:L:?1	R:R:I322	3.59	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y326	14.73	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S329	5.03	1	Yes	No	0	9	0	1
R:R:L232	R:R:Y148	2.34	0	No	No	5	4	2	1
L:L:?1	R:R:G325	1.43	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7U2K_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	257
Number of Links	275
Number of Hubs	32
Number of Links mediated by Hubs	127
Number of Communities	8
Number of Nodes involved in Communities	30
Number of Links involved in Communities	34

Path Summary
Number Of Nodes in MetaPath	112
Number Of Links MetaPath	111
Number of Shortest Paths	34313
Length Of Smallest Path	3
Average Path Length	12.2477
Length of Longest Path	33
Minimum Path Strength	1.155
Average Path Strength	5.36128
Maximum Path Strength	13.205
Minimum Path Correlation	0.7
Average Path Correlation	0.929182
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	55.2402
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7016
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled opioid receptor activity • G-protein alpha-subunit binding • peptide receptor activity • beta-endorphin receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • behavior • multicellular organismal process • locomotory behavior • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • G protein-coupled opioid receptor signaling pathway • regulation of biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • negative regulation of biological process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • negative regulation of cellular process • metabolic process • regulation of nitric oxide metabolic process • regulation of metabolic process • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • sensory perception • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • regulation of protein localization • negative regulation of signaling • negative regulation of Wnt protein secretion • negative regulation of transport • negative regulation of cell communication • protein localization to extracellular region • secretion by cell • regulation of secretion by cell • negative regulation of secretion • signal release • negative regulation of secretion by cell • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • secretion • establishment of protein localization to extracellular region • regulation of establishment of protein localization • export from cell • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • protein transport • macromolecule localization • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • dendrite • dendritic tree • GABA-ergic synapse • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • axon • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of hormone secretion • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • regulation of hormone secretion • regulation of peptide secretion • hormone secretion • negative regulation of peptide secretion • peptide secretion • amide transport • regulation of peptide transport • peptide transport • negative regulation of insulin secretion • regulation of insulin secretion • peptide hormone secretion • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KZR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KZR
Name	N-(6-carbamimidamidohexyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Synonyms
Identifier
Formula	C23 H39 N5 O
Molecular Weight	401.589
SMILES
PubChem	10363696
Formal Charge	0
Total Atoms	68
Total Chiral Atoms	0
Total Bonds	69
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>7U2K_nogp_Chain_R M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	NAM	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Damgo	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	6DDE	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	Damgo	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Damgo	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7U2L	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PubChem 163201242	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published

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