psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I77	R:R:S76	6.19	No	No	0	5	4
2	R:R:I77	R:R:V81	4.61	No	No	0	5	5
3	R:R:T118	R:R:V78	4.76	No	No	0	6	7
4	R:R:C330	R:R:V78	6.83	No	No	0	7	7
5	R:R:C79	R:R:L83	3.17	No	Yes	8	6	6
6	R:R:C79	R:R:T118	8.45	No	No	8	6	6
7	R:R:F87	R:R:L83	3.65	No	Yes	0	4	6
8	R:R:A115	R:R:L83	3.15	No	Yes	0	7	6
9	R:R:L83	R:R:T118	4.42	Yes	No	8	6	6
10	R:R:G85	R:R:L88	5.13	No	No	0	7	6
11	R:R:G85	R:R:Y336	2.9	No	Yes	0	7	9
12	R:R:F87	R:R:N86	8.46	No	No	0	4	9
13	R:R:A111	R:R:N86	4.69	No	No	0	9	9
14	R:R:L88	R:R:V89	2.98	No	No	0	6	9
15	R:R:F347	R:R:L88	6.09	No	No	0	6	6
16	R:R:M99	R:R:V89	3.04	Yes	No	0	7	9
17	R:R:I93	R:R:M90	2.92	No	No	0	7	7
18	R:R:M90	R:R:V94	3.04	No	No	0	7	3
19	R:R:M99	R:R:V92	10.65	Yes	No	2	7	7
20	R:R:C346	R:R:V92	10.25	No	No	2	5	7
21	R:R:E349	R:R:V92	5.7	No	No	0	4	7
22	R:R:I93	R:R:K100	2.91	No	Yes	0	7	6
23	R:R:F108	R:R:I93	11.3	No	No	0	6	7
24	R:R:K98	R:R:Y96	11.94	No	No	0	5	5
25	R:R:K100	R:R:T97	4.5	Yes	No	0	6	6
26	R:R:K98	R:R:N342	2.8	No	Yes	0	5	6
27	R:R:K98	R:R:R345	4.95	No	No	0	5	4
28	R:R:M99	R:R:N342	12.62	Yes	Yes	2	7	6
29	R:R:F343	R:R:M99	6.22	Yes	Yes	2	9	7
30	R:R:C346	R:R:M99	9.73	No	Yes	2	5	7
31	R:R:I105	R:R:K100	2.91	Yes	Yes	0	6	6
32	R:R:K100	R:R:P181	3.35	Yes	No	0	6	1
33	R:R:T101	R:R:T103	4.71	No	No	2	8	8
34	R:R:N104	R:R:T101	10.24	Yes	No	2	8	8
35	R:R:A102	R:R:R179	2.77	No	No	0	6	6
36	R:R:N104	R:R:T103	4.39	Yes	No	2	8	8
37	R:R:I278	R:R:T103	9.12	No	No	0	7	8
38	R:R:I107	R:R:N104	2.83	No	Yes	0	8	8
39	R:R:N104	R:R:N342	2.72	Yes	Yes	2	8	6
40	R:R:F343	R:R:N104	6.04	Yes	Yes	2	9	8
41	R:R:F108	R:R:I105	2.51	No	Yes	0	6	6
42	R:R:A184	R:R:I105	4.87	No	Yes	0	7	6
43	R:R:I105	R:R:N188	4.25	Yes	No	0	6	7
44	R:R:I107	R:R:Y106	12.09	No	Yes	0	8	7
45	R:R:L110	R:R:Y106	15.24	Yes	Yes	5	9	7
46	R:R:T157	R:R:Y106	4.99	No	Yes	5	7	7
47	R:R:L158	R:R:Y106	5.86	No	Yes	5	8	7
48	R:R:M161	R:R:Y106	27.54	No	Yes	0	8	7
49	R:R:N109	R:R:N191	5.45	No	No	6	9	7
50	R:R:N109	R:R:W192	6.78	No	No	6	9	9
51	R:R:L110	R:R:T157	7.37	Yes	No	5	9	7
52	R:R:L110	R:R:L158	8.3	Yes	No	5	9	8
53	R:R:L110	R:R:N332	4.12	Yes	No	0	9	9
54	R:R:A111	R:R:D114	4.63	No	No	0	9	9
55	R:R:L112	R:R:L116	4.15	No	No	0	6	7
56	R:R:D114	R:R:S329	2.94	No	No	0	9	9
57	R:R:D114	R:R:N332	6.73	No	No	0	9	9
58	R:R:I146	R:R:L116	5.71	No	No	0	5	7
59	R:R:A117	R:R:N150	4.69	No	No	0	7	8
60	R:R:T120	R:R:V143	6.35	No	No	0	6	5
61	R:R:I146	R:R:T120	9.12	No	No	0	5	6
62	R:R:L121	R:R:P122	6.57	Yes	No	0	7	8
63	R:R:L121	R:R:S125	4.5	Yes	No	0	7	6
64	R:R:L121	R:R:Y326	5.86	Yes	No	0	7	7
65	R:R:N127	R:R:Q124	5.28	No	No	0	6	6
66	R:R:D216	R:R:N127	4.04	No	No	0	4	6
67	R:R:C217	R:R:N127	3.15	Yes	No	0	9	6
68	R:R:H319	R:R:Y128	9.8	No	No	0	4	5
69	R:R:S214	R:R:T132	6.4	No	No	0	2	5
70	R:R:P134	R:R:W133	6.76	No	Yes	0	4	8
71	R:R:F135	R:R:W133	3.01	No	Yes	3	7	8
72	R:R:L139	R:R:W133	4.56	Yes	Yes	3	6	8
73	R:R:C140	R:R:W133	10.45	No	Yes	3	9	8
74	R:R:V143	R:R:W133	4.9	No	Yes	0	5	8
75	R:R:C217	R:R:W133	3.92	Yes	Yes	3	9	8
76	R:R:F135	R:R:L139	10.96	No	Yes	3	7	6
77	R:R:C140	R:R:N137	3.15	No	No	0	9	1
78	R:R:N137	R:R:T207	2.92	No	No	0	1	5
79	R:R:N137	R:R:T208	2.92	No	No	0	1	5
80	R:R:I138	R:R:L139	5.71	No	Yes	3	2	6
81	R:R:I138	R:R:K141	13.09	No	No	3	2	6
82	R:R:I138	R:R:I142	2.94	No	No	3	2	5
83	R:R:C140	R:R:C217	7.28	No	Yes	3	9	9
84	R:R:I142	R:R:K141	2.91	No	No	3	5	6
85	R:R:K141	R:R:M203	7.2	No	No	0	6	4
86	R:R:I142	R:R:I146	2.94	No	No	0	5	5
87	R:R:A206	R:R:I144	6.5	No	No	0	4	5
88	R:R:C217	R:R:I144	3.27	Yes	No	0	9	5
89	R:R:I144	R:R:L219	9.99	No	No	0	5	5
90	R:R:M203	R:R:S145	6.13	No	No	0	4	6
91	R:R:D147	R:R:Y148	3.45	No	Yes	10	6	4
92	R:R:D147	R:R:M151	4.16	No	No	10	6	7
93	R:R:M151	R:R:Y148	15.57	No	Yes	10	7	4
94	R:R:V202	R:R:Y148	11.36	No	Yes	0	5	4
95	R:R:V236	R:R:Y148	6.31	No	Yes	0	5	4
96	R:R:T153	R:R:Y149	3.75	Yes	No	6	7	4
97	R:R:S195	R:R:Y149	12.72	No	No	6	8	4
98	R:R:F152	R:R:F156	6.43	Yes	Yes	11	7	6
99	R:R:F152	R:R:I198	8.79	Yes	No	0	7	4
100	R:R:F152	R:R:F239	5.36	Yes	No	11	7	4
101	R:R:A240	R:R:F152	4.16	No	Yes	0	6	7
102	R:R:N191	R:R:T153	2.92	No	Yes	6	7	7
103	R:R:S195	R:R:T153	4.8	No	Yes	6	8	7
104	R:R:I155	R:R:P244	3.39	Yes	Yes	0	8	9
105	R:R:F289	R:R:I155	12.56	Yes	Yes	5	9	8
106	R:R:I155	R:R:W293	8.22	Yes	Yes	5	8	8
107	R:R:F156	R:R:L194	6.09	Yes	No	0	6	4
108	R:R:F156	R:R:F239	4.29	Yes	No	11	6	4
109	R:R:F156	R:R:P244	2.89	Yes	Yes	0	6	9
110	R:R:F289	R:R:L158	7.31	Yes	No	5	9	8
111	R:R:C159	R:R:P244	3.77	No	Yes	0	7	9
112	R:R:C159	R:R:I247	4.91	No	No	0	7	7
113	R:R:C159	R:R:I248	3.27	No	No	0	7	8
114	R:R:T160	R:R:V187	7.93	No	No	0	7	5
115	R:R:M161	R:R:V282	9.13	No	No	0	8	7
116	R:R:I248	R:R:S162	10.84	No	No	0	8	9
117	R:R:I167	R:R:V163	3.07	Yes	No	0	5	6
118	R:R:R165	R:R:V169	3.92	Yes	No	7	9	8
119	R:R:M255	R:R:R165	13.65	Yes	Yes	7	8	9
120	R:R:R165	R:R:T279	14.23	Yes	No	7	9	6
121	R:R:R165	R:R:V282	3.92	Yes	No	0	9	7
122	R:R:C170	R:R:Y166	6.72	No	Yes	4	7	8
123	R:R:H171	R:R:Y166	8.71	Yes	Yes	4	6	8
124	R:R:C251	R:R:Y166	5.38	No	Yes	0	7	8
125	R:R:L254	R:R:Y166	12.89	No	Yes	4	4	8
126	R:R:H171	R:R:I167	6.63	Yes	Yes	4	6	5
127	R:R:I167	R:R:K174	4.36	Yes	Yes	4	5	4
128	R:R:F178	R:R:I167	6.28	No	Yes	4	4	5
129	R:R:M255	R:R:V169	9.13	Yes	No	7	8	8
130	R:R:C170	R:R:L254	4.76	No	No	4	7	4
131	R:R:C170	R:R:R258	2.79	No	No	0	7	5
132	R:R:H171	R:R:K174	7.86	Yes	Yes	4	6	4
133	R:R:D177	R:R:K174	16.59	No	Yes	4	4	4
134	R:R:F178	R:R:K174	8.69	No	Yes	4	4	4
135	R:R:L176	R:R:T180	2.95	No	No	0	5	7
136	R:R:D177	R:R:F178	8.36	No	No	4	4	4
137	R:R:P181	R:R:R179	4.32	No	No	0	1	6
138	R:R:P181	R:R:T180	5.25	No	No	0	1	7
139	R:R:N183	R:R:T180	5.85	No	No	0	4	7
140	R:R:K185	R:R:R182	8.66	No	No	0	2	3
141	R:R:I186	R:R:R182	6.26	No	No	0	3	3
142	R:R:K185	R:R:N188	2.8	No	No	0	2	7
143	R:R:K185	R:R:V189	6.07	No	No	0	2	4
144	R:R:N188	R:R:V187	4.43	No	No	0	7	5
145	R:R:N191	R:R:W192	5.65	No	No	6	7	9
146	R:R:S195	R:R:W192	3.71	No	No	6	8	9
147	R:R:I198	R:R:L194	2.85	No	No	0	4	4
148	R:R:G199	R:R:I198	3.53	No	No	0	7	4
149	R:R:G199	R:R:V202	3.68	No	No	0	7	5
150	R:R:L200	R:R:P201	3.28	No	No	0	3	7
151	R:R:L200	R:R:M203	2.83	No	No	0	3	4
152	R:R:K209	R:R:T207	4.5	Yes	No	9	3	5
153	R:R:T207	R:R:T220	4.71	No	No	9	5	4
154	R:R:I215	R:R:T208	3.04	No	No	0	4	5
155	R:R:K209	R:R:T218	6.01	Yes	No	0	3	3
156	R:R:K209	R:R:T220	16.52	Yes	No	9	3	4
157	R:R:F221	R:R:K209	2.48	Yes	Yes	0	5	3
158	R:R:I215	R:R:Y210	3.63	No	No	0	4	1
159	R:R:D216	R:R:R211	17.87	No	No	0	4	3
160	R:R:D216	R:R:T218	2.89	No	No	0	4	3
161	R:R:F221	R:R:T225	9.08	Yes	No	0	5	3
162	R:R:F221	R:R:W226	3.01	Yes	No	0	5	2
163	R:R:E229	R:R:F221	12.83	No	Yes	0	4	5
164	R:R:N230	R:R:W226	3.39	No	No	0	3	2
165	R:R:E229	R:R:K233	2.7	No	No	0	4	4
166	R:R:K233	R:R:N230	2.8	No	No	0	4	3
167	R:R:I234	R:R:N230	2.83	Yes	No	0	4	3
168	R:R:I234	R:R:L231	2.85	Yes	No	0	4	4
169	R:R:F237	R:R:I234	7.54	Yes	Yes	0	5	4
170	R:R:F237	R:R:I238	11.3	Yes	No	1	5	4
171	R:R:F237	R:R:I242	2.51	Yes	No	1	5	5
172	R:R:F237	R:R:H297	16.97	Yes	No	1	5	8
173	R:R:F237	R:R:I301	6.28	Yes	Yes	1	5	6
174	R:R:I238	R:R:I242	5.89	No	No	1	4	5
175	R:R:F239	R:R:M243	2.49	No	No	0	4	5
176	R:R:F241	R:R:W293	8.02	No	Yes	0	8	8
177	R:R:F241	R:R:T294	5.19	No	No	0	8	5
178	R:R:F241	R:R:H297	18.1	No	No	0	8	8
179	R:R:M243	R:R:P244	5.03	No	Yes	0	5	9
180	R:R:I247	R:R:M243	4.37	No	No	0	7	5
181	R:R:I290	R:R:V245	7.68	No	No	0	5	6
182	R:R:L246	R:R:V250	2.98	No	No	0	3	4
183	R:R:I248	R:R:V286	9.22	No	No	0	8	8
184	R:R:L283	R:R:Y252	22.27	No	No	0	4	9
185	R:R:M255	R:R:T279	9.03	Yes	No	7	8	6
186	R:R:I256	R:R:L257	2.85	No	No	0	5	2
187	R:R:L275	R:R:R276	12.15	No	No	0	6	5
188	R:R:D340	R:R:R277	7.15	Yes	No	2	8	7
189	R:R:E341	R:R:R277	8.14	No	No	2	4	7
190	R:R:I278	R:R:M281	2.92	No	No	0	7	8
191	R:R:I278	R:R:V282	3.07	No	No	0	7	7
192	R:R:L283	R:R:R280	3.64	No	No	0	4	6
193	R:R:L339	R:R:M281	11.31	No	No	0	6	8
194	R:R:D340	R:R:M281	2.77	Yes	No	0	8	8
195	R:R:L283	R:R:V284	4.47	No	No	0	4	6
196	R:R:L335	R:R:V285	2.98	Yes	No	0	8	8
197	R:R:L331	R:R:V288	2.98	No	No	0	7	6
198	R:R:C292	R:R:F289	5.59	No	Yes	0	8	9
199	R:R:F289	R:R:W293	8.02	Yes	Yes	5	9	8
200	R:R:F289	R:R:N328	6.04	Yes	No	0	9	9
201	R:R:I296	R:R:W293	8.22	No	Yes	0	6	8
202	R:R:P295	R:R:T294	5.25	No	No	0	9	5
203	R:R:L324	R:R:P295	3.28	No	No	0	7	9
204	R:R:I296	R:R:V300	4.61	No	No	0	6	5
205	R:R:H297	R:R:I301	7.95	No	Yes	1	8	6
206	R:R:I298	R:R:Y299	3.63	No	Yes	0	6	4
207	R:R:Q314	R:R:Y299	4.51	Yes	Yes	1	4	4
208	R:R:S317	R:R:Y299	12.72	No	Yes	1	5	4
209	R:R:W318	R:R:Y299	8.68	Yes	Yes	1	5	4
210	R:R:C321	R:R:Y299	6.72	No	Yes	1	6	4
211	R:R:I301	R:R:L305	4.28	Yes	No	0	6	5
212	R:R:I301	R:R:I306	2.94	Yes	No	1	6	3
213	R:R:I302	R:R:I306	10.3	No	No	1	5	3
214	R:R:I302	R:R:I308	2.94	No	No	1	5	1
215	R:R:I302	R:R:Q314	2.74	No	Yes	1	5	4
216	R:R:K303	R:R:W318	8.12	No	Yes	0	4	5
217	R:R:I306	R:R:I308	7.36	No	No	1	3	1
218	R:R:I308	R:R:P309	8.47	No	No	0	1	3
219	R:R:Q314	R:R:T311	4.25	Yes	No	0	4	1
220	R:R:F313	R:R:T312	2.59	No	No	0	2	4
221	R:R:F313	R:R:V316	2.62	No	No	0	2	1
222	R:R:Q314	R:R:S317	5.78	Yes	No	1	4	5
223	R:R:Q314	R:R:W318	15.33	Yes	Yes	1	4	5
224	R:R:C321	R:R:W318	3.92	No	Yes	1	6	5
225	R:R:I322	R:R:Y326	10.88	No	No	0	5	7
226	R:R:C330	R:R:T327	3.38	No	No	0	7	5
227	R:R:N328	R:R:S329	4.47	No	No	0	9	9
228	R:R:L331	R:R:V334	4.47	No	No	12	7	6
229	R:R:L331	R:R:L335	8.3	No	Yes	12	7	8
230	R:R:N332	R:R:P333	9.77	No	No	0	9	9
231	R:R:P333	R:R:Y336	4.17	No	Yes	0	9	9
232	R:R:L335	R:R:V334	2.98	Yes	No	12	8	6
233	R:R:F338	R:R:V334	2.62	No	No	0	6	6
234	R:R:L335	R:R:L339	9.69	Yes	No	0	8	6
235	R:R:A337	R:R:Y336	2.67	No	Yes	0	7	9
236	R:R:F343	R:R:Y336	10.32	Yes	Yes	0	9	9
237	R:R:F347	R:R:Y336	3.09	No	Yes	0	6	9
238	R:R:A337	R:R:K344	3.21	No	No	0	7	8
239	R:R:D340	R:R:E341	2.6	Yes	No	2	8	4
240	R:R:D340	R:R:N342	8.08	Yes	Yes	2	8	6
241	R:R:D340	R:R:F343	13.14	Yes	Yes	2	8	9
242	R:R:F343	R:R:N342	12.08	Yes	Yes	2	9	6
243	R:R:R345	R:R:R348	4.26	No	No	0	4	5
244	R:R:E349	R:R:R345	4.65	No	No	0	4	4
245	R:R:C351	R:R:F347	2.79	No	No	0	5	6
246	R:R:C351	R:R:R348	2.79	No	No	0	5	5
247	R:R:I352	R:R:R348	3.76	No	No	0	2	5
248	R:R:E349	R:R:F350	3.5	No	No	0	4	5
249	R:R:F108	R:R:N104	2.42	No	Yes	0	6	8
250	R:R:L129	R:R:Y128	2.34	No	No	0	5	5
251	R:R:R277	R:R:R280	2.13	No	No	0	7	6
252	R:R:G82	R:R:P333	2.03	No	No	0	8	9
253	R:R:F123	R:R:W133	2	No	Yes	0	6	8
254	R:R:W226	R:R:Y227	1.93	No	No	0	2	3
255	R:R:G213	R:R:S214	1.86	No	No	0	3	2
256	R:R:G82	R:R:V81	1.84	No	No	0	8	5
257	R:R:G253	R:R:I256	1.76	No	No	0	2	5
258	R:R:G131	R:R:M130	1.75	No	No	0	4	3
259	R:R:C251	R:R:S162	1.72	No	No	0	7	9
260	R:R:A113	R:R:S154	1.71	No	No	0	8	9
261	R:R:G136	R:R:L139	1.71	No	Yes	0	7	6
262	R:R:C190	R:R:V189	1.71	No	No	0	4	4
263	R:R:G325	R:R:L324	1.71	No	No	0	7	7
264	R:R:A113	R:R:T153	1.68	No	Yes	0	8	7
265	R:R:G213	R:R:Q212	1.64	No	No	0	3	5
266	R:R:C235	R:R:I234	1.64	No	Yes	0	3	4
267	R:R:S119	R:R:T120	1.6	No	No	0	5	6
268	R:R:V288	R:R:V291	1.6	No	No	0	6	6
269	R:R:T249	R:R:V245	1.59	No	No	0	4	6
270	R:R:A117	R:R:L116	1.58	No	No	0	7	7
271	R:R:I155	R:R:S154	1.55	Yes	No	0	8	9
272	R:R:I193	R:R:S196	1.55	No	No	0	4	3
273	R:R:I215	R:R:S214	1.55	No	No	0	4	2
274	R:R:A102	R:R:D164	1.54	No	No	0	6	8
275	R:R:I193	R:R:V189	1.54	No	No	0	4	4
276	R:R:I290	R:R:V291	1.54	No	No	0	5	6
277	R:R:H171	R:R:P172	1.53	Yes	No	0	6	7
278	R:R:M205	R:R:S222	1.53	No	No	0	4	6
279	R:R:M130	R:R:V126	1.52	No	No	0	3	5
280	R:R:F84	R:R:G85	1.51	No	No	0	4	7
281	R:R:G253	R:R:Y252	1.45	No	No	0	2	9
282	R:R:L259	R:R:M255	1.41	No	Yes	0	8	8
283	R:R:L275	R:R:N274	1.37	No	No	0	6	5
284	R:R:L121	R:R:Q124	1.33	Yes	No	0	7	6
285	R:R:H319	R:R:I322	1.33	No	No	0	4	5
286	R:R:E341	R:R:N274	1.31	No	No	0	4	5
287	R:R:T315	R:R:W318	1.21	No	Yes	0	4	5
288	R:R:L231	R:R:W228	1.14	No	No	0	4	3
289	R:R:R273	R:R:R276	1.07	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L83	3.5975	4	8	6
2	R:R:M99	8.452	5	2	7
3	R:R:K100	3.4175	4	0	6
4	R:R:N104	4.77333	6	2	8
5	R:R:I105	3.635	4	0	6
6	R:R:Y106	13.144	5	5	7
7	R:R:L110	8.7575	4	5	9
8	R:R:L121	4.565	4	0	7
9	R:R:W133	5.08571	7	3	8
10	R:R:L139	5.735	4	3	6
11	R:R:Y148	9.1725	4	10	4
12	R:R:F152	6.185	4	11	7
13	R:R:T153	3.2875	4	6	7
14	R:R:I155	6.43	4	5	8
15	R:R:F156	4.925	4	11	6
16	R:R:R165	8.93	4	7	9
17	R:R:Y166	8.425	4	4	8
18	R:R:I167	5.085	4	4	5
19	R:R:H171	6.1825	4	4	6
20	R:R:K174	9.375	4	4	4
21	R:R:K209	7.3775	4	9	3
22	R:R:C217	4.405	4	3	9
23	R:R:F221	6.85	4	0	5
24	R:R:I234	3.715	4	0	4
25	R:R:F237	8.92	5	1	5
26	R:R:P244	3.77	4	0	9
27	R:R:M255	8.305	4	7	8
28	R:R:F289	7.904	5	5	9
29	R:R:W293	8.12	4	5	8
30	R:R:Y299	7.252	5	1	4
31	R:R:I301	5.3625	4	1	6
32	R:R:Q314	6.522	5	1	4
33	R:R:W318	7.452	5	1	5
34	R:R:L335	5.9875	4	12	8
35	R:R:Y336	4.63	5	0	9
36	R:R:D340	6.748	5	2	8
37	R:R:N342	7.66	5	2	6
38	R:R:F343	9.56	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N332	R:R:P333	19.5724	9.77	No	No	0	9	9
2	R:R:A111	R:R:D114	15.4231	4.63	No	No	0	9	9
3	R:R:A111	R:R:N86	13.9277	4.69	No	No	0	9	9
4	R:R:F87	R:R:N86	12.4217	8.46	No	No	0	4	9
5	R:R:F87	R:R:L83	10.9052	3.65	No	Yes	0	4	6
6	R:R:P333	R:R:Y336	17.4398	4.17	No	Yes	0	9	9
7	R:R:F343	R:R:Y336	11.4581	10.32	Yes	Yes	0	9	9
8	R:R:F343	R:R:N104	29.4982	6.04	Yes	Yes	2	9	8
9	R:R:F108	R:R:N104	52.0931	2.42	No	Yes	0	6	8
10	R:R:F108	R:R:I93	18.6351	11.3	No	No	0	6	7
11	R:R:I93	R:R:K100	14.1646	2.91	No	Yes	0	7	6
12	R:R:F108	R:R:I105	32.4733	2.51	No	Yes	0	6	6
13	R:R:I105	R:R:K100	14.5911	2.91	Yes	Yes	0	6	6
14	R:R:K100	R:R:P181	22.1473	3.35	Yes	No	0	6	1
15	R:R:I278	R:R:M281	14.312	2.92	No	No	0	7	8
16	R:R:D340	R:R:M281	10.4576	2.77	Yes	No	0	8	8
17	R:R:D340	R:R:F343	21.7945	13.14	Yes	Yes	2	8	9
18	R:R:I107	R:R:N104	72.229	2.83	No	Yes	0	8	8
19	R:R:I107	R:R:Y106	72.429	12.09	No	Yes	0	8	7
20	R:R:L110	R:R:N332	17.1871	4.12	Yes	No	0	9	9
21	R:R:I105	R:R:N188	16.2656	4.25	Yes	No	0	6	7
22	R:R:L110	R:R:L158	14.7702	8.3	Yes	No	5	9	8
23	R:R:M161	R:R:Y106	17.1134	27.54	No	Yes	0	8	7
24	R:R:F289	R:R:L158	100	7.31	Yes	No	5	9	8
25	R:R:F289	R:R:I155	38.6657	12.56	Yes	Yes	5	9	8
26	R:R:I155	R:R:S154	13.2168	1.55	Yes	No	0	8	9
27	R:R:A113	R:R:S154	11.7898	1.71	No	No	0	8	9
28	R:R:A113	R:R:T153	10.3523	1.68	No	Yes	0	8	7
29	R:R:F289	R:R:W293	70.5124	8.02	Yes	Yes	5	9	8
30	R:R:F241	R:R:W293	93.8287	8.02	No	Yes	0	8	8
31	R:R:F241	R:R:H297	90.8536	18.1	No	No	0	8	8
32	R:R:F237	R:R:H297	73.0399	16.97	Yes	No	1	5	8
33	R:R:F237	R:R:I234	76.3204	7.54	Yes	Yes	0	5	4
34	R:R:I234	R:R:N230	72.9082	2.83	Yes	No	0	4	3
35	R:R:N230	R:R:W226	69.6383	3.39	No	No	0	3	2
36	R:R:F221	R:R:W226	67.8269	3.01	Yes	No	0	5	2
37	R:R:F221	R:R:K209	66.5315	2.48	Yes	Yes	0	5	3
38	R:R:K209	R:R:T207	43.5048	4.5	Yes	No	9	3	5
39	R:R:N137	R:R:T207	42.6097	2.92	No	No	0	1	5
40	R:R:C140	R:R:N137	34.1004	3.15	No	No	0	9	1
41	R:R:C140	R:R:W133	27.1971	10.45	No	Yes	3	9	8
42	R:R:V143	R:R:W133	11.3054	4.9	No	Yes	0	5	8
43	R:R:K209	R:R:T218	21.2996	6.01	Yes	No	0	3	3
44	R:R:D216	R:R:T218	20.2043	2.89	No	No	0	4	3
45	R:R:D216	R:R:N127	18.077	4.04	No	No	0	4	6
46	R:R:N127	R:R:Q124	13.0746	5.28	No	No	0	6	6
47	R:R:L121	R:R:Q124	11.6634	1.33	Yes	No	0	7	6
48	R:R:N137	R:R:T208	10.2786	2.92	No	No	0	1	5
49	R:R:L139	R:R:W133	12.6639	4.56	Yes	Yes	3	6	8
50	R:R:I138	R:R:L139	10.0205	5.71	No	Yes	3	2	6
51	R:R:V202	R:R:Y148	11.3896	11.36	No	Yes	0	5	4
52	R:R:G199	R:R:V202	14.212	3.68	No	No	0	7	5
53	R:R:G199	R:R:I198	17.0239	3.53	No	No	0	7	4
54	R:R:F152	R:R:F156	12.6112	6.43	Yes	Yes	11	7	6
55	R:R:F156	R:R:P244	26.5389	2.89	Yes	Yes	0	6	9
56	R:R:I155	R:R:P244	53.32	3.39	Yes	Yes	0	8	9
57	R:R:F156	R:R:L194	11.2422	6.09	Yes	No	0	6	4
58	R:R:C159	R:R:P244	25.391	3.77	No	Yes	0	7	9
59	R:R:C159	R:R:I248	22.9951	3.27	No	No	0	7	8
60	R:R:M161	R:R:V282	15.9918	9.13	No	No	0	8	7
61	R:R:I248	R:R:S162	20.2675	10.84	No	No	0	8	9
62	R:R:H171	R:R:Y166	11.8319	8.71	Yes	Yes	4	6	8
63	R:R:C251	R:R:Y166	17.4978	5.38	No	Yes	0	7	8
64	R:R:C251	R:R:S162	18.8879	1.72	No	No	0	7	9
65	R:R:K185	R:R:N188	11.4949	2.8	No	No	0	2	7
66	R:R:H297	R:R:I301	17.1818	7.95	No	Yes	1	8	6
67	R:R:L331	R:R:L335	10.6419	8.3	No	Yes	12	7	8
68	R:R:L335	R:R:L339	17.6347	9.69	Yes	No	0	8	6
69	R:R:L339	R:R:M281	19.3407	11.31	No	No	0	6	8
70	R:R:D340	R:R:R277	19.0353	7.15	Yes	No	2	8	7
71	R:R:R277	R:R:R280	16.8764	2.13	No	No	0	7	6
72	R:R:L283	R:R:R280	14.4963	3.64	No	No	0	4	6
73	R:R:D340	R:R:E341	11.8951	2.6	Yes	No	2	8	4
74	R:R:I302	R:R:Q314	14.6332	2.74	No	Yes	1	5	4
75	R:R:I302	R:R:I306	15.9233	10.3	No	No	1	5	3
76	R:R:I301	R:R:I306	20.1938	2.94	Yes	No	1	6	3
77	R:R:I278	R:R:V282	14.6017	3.07	No	No	0	7	7
78	R:R:F289	R:R:N328	10.8209	6.04	Yes	No	0	9	9
79	R:R:N104	R:R:N342	30.9515	2.72	Yes	Yes	2	8	6
80	R:R:D340	R:R:N342	18.8089	8.08	Yes	Yes	2	8	6
81	R:R:L158	R:R:Y106	85.1772	5.86	No	Yes	5	8	7
82	R:R:I155	R:R:W293	24.9697	8.22	Yes	Yes	5	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9ODK_nogp

PDB Summary
PDB	9ODK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.48
Number of Linked Nodes	247
Number of Links	289
Number of Hubs	38
Number of Links mediated by Hubs	139
Number of Communities	12
Number of Nodes involved in Communities	72
Number of Links involved in Communities	92

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	40465
Length Of Smallest Path	3
Average Path Length	14.8533
Length of Longest Path	34
Minimum Path Strength	1.34
Average Path Strength	6.27217
Maximum Path Strength	21.39
Minimum Path Correlation	0.86
Average Path Correlation	0.994044
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	33.3333
Average % Of Corr. Nodes	96.8871
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.8444
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • neuropeptide binding • peptide binding • G-protein alpha-subunit binding • peptide receptor activity • molecular transducer activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • protein domain specific binding • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • G protein-coupled opioid receptor signaling pathway • multi-multicellular organism process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • transmission of nerve impulse • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • positive regulation of biological process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • neurogenesis • positive regulation of cell differentiation • cell differentiation • positive regulation of neurogenesis • regulation of multicellular organismal process • positive regulation of cellular process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • neuropeptide signaling pathway • monosaccharide metabolic process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • locomotory behavior • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of transport • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of hormone levels • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • secretion • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • eating behavior • feeding behavior • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • adenylate cyclase-inhibiting opioid receptor signaling pathway • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • regulation of nitric oxide metabolic process • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • adult behavior • behavioral response to ethanol • response to ethanol • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • biological process involved in intraspecies interaction between organisms • social behavior • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • regulation of protein localization • negative regulation of Wnt protein secretion • protein localization to extracellular region • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • establishment of protein localization to extracellular region • regulation of establishment of protein localization • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • negative regulation of protein secretion • protein transport • macromolecule localization • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • dendrite • dendritic tree • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • axon • mitochondrion • anchoring junction • focal adhesion • cell-substrate junction • GABA-ergic synapse • neuron projection cytoplasm • dendrite cytoplasm • cell leading edge • leading edge membrane • neuron projection membrane • dendrite membrane • cell projection membrane • endosome • intracellular vesicle • cytoplasmic vesicle • neuron spine • dendritic spine • spine apparatus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Galpha insert domain-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Galpha insert domain-like • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MG
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	MG
Name	MAGNESIUM ION
Synonyms
Identifier
Formula	Mg
Molecular Weight	24.305
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>9ODK_nogp_Chain_R S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R C F R E F C I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

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Download 9ODK_nogp.zip

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