| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F1O | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP; Mg | Gs/Beta1/Gamma2 | 3.13 | 2022-06-15 | 10.1126/sciadv.abo4158 |
|
A 2D representation of the interactions of MG in 7F1O
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:K53 | A:A:L45 | 5.64 | 0 | No | No | 9 | 8 | 2 | 2 | | A:A:D223 | A:A:L45 | 4.07 | 0 | No | No | 9 | 8 | 1 | 2 | | A:A:G52 | A:A:T55 | 3.64 | 2 | No | No | 9 | 9 | 2 | 2 | | A:A:G52 | W:W:?1 | 4.62 | 2 | No | Yes | 9 | 0 | 2 | 1 | | A:A:K53 | W:W:?1 | 6.1 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:S54 | M:M:?1 | 5.77 | 2 | No | No | 9 | 0 | 1 | 0 | | A:A:S54 | W:W:?1 | 9.74 | 2 | No | Yes | 9 | 0 | 1 | 1 | | A:A:T55 | W:W:?1 | 9.56 | 2 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D223 | A:A:V57 | 5.84 | 0 | No | No | 9 | 7 | 1 | 2 | | A:A:D223 | M:M:?1 | 5.21 | 0 | No | No | 9 | 0 | 1 | 0 | | A:A:K293 | A:A:N292 | 5.6 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N292 | W:W:?1 | 4.45 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K293 | W:W:?1 | 22.1 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:D295 | W:W:?1 | 7.34 | 0 | No | Yes | 9 | 0 | 2 | 1 | | M:M:?1 | W:W:?1 | 7.19 | 2 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.06 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPB | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin 8-13 | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
|
A 2D representation of the interactions of MG in 8JPB
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:?3 | A:A:G48 | 4.58 | 11 | Yes | No | 6 | 7 | 1 | 2 | | A:A:G51 | N:N:?1 | 7.4 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D205 | A:A:K52 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 2 | | A:A:K52 | N:N:?1 | 10.67 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:S53 | A:A:T186 | 6.4 | 11 | Yes | No | 9 | 9 | 1 | 1 | | A:A:D205 | A:A:S53 | 5.89 | 0 | No | Yes | 9 | 9 | 2 | 1 | | A:A:S53 | N:N:?1 | 6.49 | 11 | Yes | Yes | 9 | 0 | 1 | 1 | | A:A:?2 | A:A:S53 | 5.77 | 11 | Yes | Yes | 5 | 9 | 0 | 1 | | A:A:T54 | N:N:?1 | 14.34 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D155 | A:A:K275 | 6.91 | 11 | No | Yes | 8 | 9 | 2 | 2 | | A:A:D155 | N:N:?1 | 15.41 | 11 | No | Yes | 8 | 0 | 2 | 1 | | A:A:?2 | A:A:T186 | 8.49 | 11 | Yes | No | 5 | 9 | 0 | 1 | | A:A:?3 | A:A:T186 | 3.94 | 11 | Yes | No | 6 | 9 | 1 | 1 | | A:A:K275 | A:A:N274 | 5.6 | 11 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N274 | N:N:?1 | 9.65 | 11 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K275 | N:N:?1 | 18.29 | 11 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:D277 | N:N:?1 | 8.07 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:T332 | N:N:?1 | 16.73 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:?2 | N:N:?1 | 11.5 | 11 | Yes | Yes | 5 | 0 | 0 | 1 | | A:A:?3 | N:N:?1 | 14.02 | 11 | Yes | Yes | 6 | 0 | 1 | 1 | | A:A:?2 | A:A:?3 | 9.49 | 11 | Yes | Yes | 5 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.81 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 21.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPC | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin 8-13 | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
|
A 2D representation of the interactions of MG in 8JPC
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:?403 | A:A:G48 | 4.58 | 9 | Yes | No | 0 | 7 | 1 | 2 | | A:A:G51 | N:N:?1 | 7.4 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D205 | A:A:K52 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 2 | | A:A:K52 | N:N:?1 | 10.67 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:S53 | A:A:T186 | 4.8 | 9 | Yes | No | 9 | 9 | 1 | 1 | | A:A:D205 | A:A:S53 | 5.89 | 0 | No | Yes | 9 | 9 | 2 | 1 | | A:A:S53 | N:N:?1 | 6.49 | 9 | Yes | Yes | 9 | 0 | 1 | 1 | | A:A:S53 | I:I:?1 | 5.77 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | | A:A:T54 | N:N:?1 | 14.34 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D155 | A:A:K275 | 6.91 | 9 | No | Yes | 8 | 9 | 2 | 2 | | A:A:D155 | N:N:?1 | 15.41 | 9 | No | Yes | 8 | 0 | 2 | 1 | | A:A:R183 | N:N:?1 | 8.54 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:?403 | A:A:R183 | 6.5 | 9 | Yes | Yes | 0 | 9 | 1 | 2 | | A:A:T186 | I:I:?1 | 8.49 | 9 | No | Yes | 9 | 0 | 1 | 0 | | A:A:?403 | A:A:T186 | 3.94 | 9 | Yes | No | 0 | 9 | 1 | 1 | | A:A:K275 | A:A:N274 | 5.6 | 9 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N274 | N:N:?1 | 9.65 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K275 | N:N:?1 | 18.29 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:D277 | N:N:?1 | 8.07 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:T332 | N:N:?1 | 16.73 | 0 | No | Yes | 9 | 0 | 2 | 1 | | I:I:?1 | N:N:?1 | 11.5 | 9 | Yes | Yes | 0 | 0 | 0 | 1 | | A:A:?403 | N:N:?1 | 13.35 | 9 | Yes | Yes | 0 | 0 | 1 | 1 | | A:A:?403 | I:I:?1 | 9.49 | 9 | Yes | Yes | 0 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.81 | | Average Nodes In Shell | 16.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO1 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
|
A 2D representation of the interactions of MG in 8UO1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 2 | 1 | | A:A:D173 | A:A:E50 | 3.9 | 7 | No | No | 9 | 9 | 2 | 2 | | A:A:E50 | M:M:?1 | 4.22 | 7 | No | Yes | 9 | 0 | 2 | 1 | | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:K53 | M:M:?1 | 4.49 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:A366 | A:A:T55 | 3.36 | 7 | No | No | 9 | 9 | 2 | 2 | | A:A:T55 | M:M:?1 | 4.69 | 7 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D173 | A:A:K293 | 6.91 | 7 | No | Yes | 9 | 9 | 2 | 2 | | A:A:D173 | M:M:?1 | 7.2 | 7 | No | Yes | 9 | 0 | 2 | 1 | | A:A:R199 | A:A:V367 | 2.62 | 7 | Yes | Yes | 7 | 9 | 2 | 2 | | A:A:R199 | M:M:?1 | 5.8 | 7 | Yes | Yes | 7 | 0 | 2 | 1 | | A:A:R201 | M:M:?1 | 9.67 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:L203 | A:A:Q227 | 17.3 | 0 | No | No | 7 | 9 | 1 | 2 | | A:A:L203 | I:I:?402 | 2.66 | 0 | No | No | 7 | 0 | 1 | 0 | | A:A:K293 | A:A:N292 | 4.2 | 7 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:A366 | A:A:N292 | 4.69 | 7 | No | Yes | 9 | 9 | 2 | 2 | | A:A:N292 | M:M:?1 | 7.28 | 7 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K293 | M:M:?1 | 16.46 | 7 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:C365 | M:M:?1 | 3.37 | 0 | No | Yes | 8 | 0 | 2 | 1 | | A:A:A366 | M:M:?1 | 4.18 | 7 | No | Yes | 9 | 0 | 2 | 1 | | A:A:V367 | M:M:?1 | 4.74 | 7 | Yes | Yes | 9 | 0 | 2 | 1 | | I:I:?402 | M:M:?1 | 2.82 | 0 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.74 | | Average Nodes In Shell | 18.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO3 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
|
A 2D representation of the interactions of MG in 8UO3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:G52 | M:M:?1 | 8.17 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D223 | A:A:K53 | 4.15 | 0 | No | No | 9 | 9 | 2 | 2 | | A:A:K53 | M:M:?1 | 11.22 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D223 | A:A:S54 | 2.94 | 0 | No | No | 9 | 9 | 2 | 1 | | A:A:S54 | M:M:?1 | 3.19 | 1 | No | Yes | 9 | 0 | 1 | 1 | | A:A:S54 | I:I:?402 | 5.77 | 1 | No | No | 9 | 0 | 1 | 0 | | A:A:T55 | M:M:?1 | 5.47 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D173 | M:M:?1 | 15.84 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:R201 | M:M:?1 | 5.8 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:F208 | A:A:T204 | 3.89 | 0 | No | No | 5 | 9 | 2 | 1 | | A:A:T204 | I:I:?402 | 8.49 | 0 | No | No | 9 | 0 | 1 | 0 | | A:A:K293 | M:M:?1 | 6.73 | 1 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:C365 | A:A:D295 | 4.67 | 1 | No | No | 8 | 9 | 2 | 2 | | A:A:D295 | M:M:?1 | 4.32 | 1 | No | Yes | 9 | 0 | 2 | 1 | | A:A:C365 | M:M:?1 | 3.37 | 1 | No | Yes | 8 | 0 | 2 | 1 | | A:A:V367 | M:M:?1 | 7.9 | 1 | No | Yes | 9 | 0 | 2 | 1 | | I:I:?402 | M:M:?1 | 5.64 | 1 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.63 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO4 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
|
A 2D representation of the interactions of MG in 8UO4
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:D223 | A:A:V224 | 4.38 | 0 | No | No | 9 | 9 | 2 | 1 | | A:A:V224 | I:I:?402 | 2.86 | 0 | No | No | 9 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.86 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
