| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F1O | A | Amine | Dopamine | D1 | Homo Sapiens | Dopamine | GDP; Mg | Gs/Beta1/Gamma2 | 3.13 | 2022-06-15 | 10.1126/sciadv.abo4158 |
|
A 2D representation of the interactions of MG in 7F1O
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:K53 | A:A:L45 | 5.64 | 0 | No | No | 9 | 8 | 2 | 2 | | A:A:D223 | A:A:L45 | 4.07 | 0 | No | No | 9 | 8 | 1 | 2 | | A:A:G52 | A:A:T55 | 3.64 | 2 | No | No | 9 | 9 | 2 | 2 | | A:A:G52 | O:O:?1 | 4.64 | 2 | No | Yes | 9 | 0 | 2 | 1 | | A:A:K53 | O:O:?1 | 6.12 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:S54 | I:I:?1 | 5.78 | 2 | No | No | 9 | 0 | 1 | 0 | | A:A:S54 | O:O:?1 | 9.78 | 2 | No | Yes | 9 | 0 | 1 | 1 | | A:A:T55 | O:O:?1 | 9.6 | 2 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D223 | A:A:V57 | 5.84 | 0 | No | No | 9 | 7 | 1 | 2 | | A:A:D223 | I:I:?1 | 5.22 | 0 | No | No | 9 | 0 | 1 | 0 | | A:A:K293 | A:A:N292 | 5.6 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N292 | O:O:?1 | 4.47 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K293 | O:O:?1 | 22.19 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:D295 | O:O:?1 | 7.36 | 0 | No | Yes | 9 | 0 | 2 | 1 | | I:I:?1 | O:O:?1 | 7.23 | 2 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.08 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPB | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin-(8-13) | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
|
A 2D representation of the interactions of MG in 8JPB
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | I:I:?1 | I:I:?2 | 9.64 | 10 | Yes | Yes | 0 | 0 | 0 | 1 | | A:A:S53 | I:I:?1 | 5.78 | 10 | Yes | Yes | 9 | 0 | 1 | 0 | | A:A:T186 | I:I:?1 | 8.51 | 10 | No | Yes | 9 | 0 | 1 | 0 | | I:I:?1 | O:O:?1 | 11.56 | 10 | Yes | Yes | 0 | 0 | 0 | 1 | | A:A:G48 | I:I:?2 | 4.64 | 0 | No | Yes | 7 | 0 | 2 | 1 | | A:A:T186 | I:I:?2 | 4 | 10 | No | Yes | 9 | 0 | 1 | 1 | | I:I:?2 | O:O:?1 | 14.26 | 10 | Yes | Yes | 0 | 0 | 1 | 1 | | A:A:G51 | O:O:?1 | 7.42 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D205 | A:A:K52 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 2 | | A:A:K52 | O:O:?1 | 10.71 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:S53 | A:A:T186 | 6.4 | 10 | Yes | No | 9 | 9 | 1 | 1 | | A:A:D205 | A:A:S53 | 5.89 | 0 | No | Yes | 9 | 9 | 2 | 1 | | A:A:S53 | O:O:?1 | 6.52 | 10 | Yes | Yes | 9 | 0 | 1 | 1 | | A:A:T54 | O:O:?1 | 14.39 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D155 | A:A:K275 | 6.91 | 10 | No | Yes | 8 | 9 | 2 | 2 | | A:A:D155 | O:O:?1 | 15.46 | 10 | No | Yes | 8 | 0 | 2 | 1 | | A:A:K275 | A:A:N274 | 5.6 | 10 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N274 | O:O:?1 | 9.68 | 10 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K275 | O:O:?1 | 18.36 | 10 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:D277 | O:O:?1 | 8.1 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:T332 | O:O:?1 | 16.79 | 0 | No | Yes | 9 | 0 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.87 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 21.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JPC | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin-(8-13) | PubChem 118610427; GDP; Mg | Gq; GRK2 | 3.07 | 2023-08-09 | 10.1038/s41586-023-06395-9 |
|
A 2D representation of the interactions of MG in 8JPC
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:G48 | I:I:?2 | 4.64 | 0 | No | Yes | 7 | 0 | 2 | 1 | | A:A:G51 | O:O:?1 | 7.42 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D205 | A:A:K52 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 2 | | A:A:K52 | O:O:?1 | 10.71 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:S53 | A:A:T186 | 4.8 | 9 | Yes | No | 9 | 9 | 1 | 1 | | A:A:D205 | A:A:S53 | 5.89 | 0 | No | Yes | 9 | 9 | 2 | 1 | | A:A:S53 | I:I:?1 | 5.78 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | | A:A:S53 | O:O:?1 | 6.52 | 9 | Yes | Yes | 9 | 0 | 1 | 1 | | A:A:T54 | O:O:?1 | 14.39 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D155 | A:A:K275 | 6.91 | 9 | No | Yes | 8 | 9 | 2 | 2 | | A:A:D155 | O:O:?1 | 15.46 | 9 | No | Yes | 8 | 0 | 2 | 1 | | A:A:R183 | I:I:?2 | 6.59 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:R183 | O:O:?1 | 8.57 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:T186 | I:I:?2 | 4 | 9 | No | Yes | 9 | 0 | 1 | 1 | | A:A:T186 | I:I:?1 | 8.51 | 9 | No | Yes | 9 | 0 | 1 | 0 | | A:A:K275 | A:A:N274 | 5.6 | 9 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N274 | O:O:?1 | 9.68 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K275 | O:O:?1 | 18.36 | 9 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:D277 | O:O:?1 | 8.1 | 0 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:T332 | O:O:?1 | 16.79 | 0 | No | Yes | 9 | 0 | 2 | 1 | | I:I:?1 | I:I:?2 | 9.64 | 9 | Yes | Yes | 0 | 0 | 0 | 1 | | I:I:?2 | O:O:?1 | 13.58 | 9 | Yes | Yes | 0 | 0 | 1 | 1 | | I:I:?1 | O:O:?1 | 11.56 | 9 | Yes | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 8.87 | | Average Nodes In Shell | 16.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 23.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO1 | A | Amine | Adrenergic | Beta2 | Homo Sapiens | Constrained Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
|
A 2D representation of the interactions of MG in 8UO1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:G49 | O:O:?1 | 2.75 | 0 | No | Yes | 8 | 0 | 2 | 1 | | A:A:E50 | O:O:?1 | 2.84 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:G52 | O:O:?1 | 6.41 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:K53 | O:O:?1 | 4.53 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:S54 | O:O:?1 | 6.43 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:A366 | A:A:T55 | 3.36 | 8 | Yes | No | 9 | 9 | 2 | 2 | | A:A:T55 | O:O:?1 | 4.74 | 8 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D173 | O:O:?1 | 11.63 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:R199 | A:A:V367 | 2.62 | 8 | Yes | No | 7 | 9 | 2 | 2 | | A:A:R199 | O:O:?1 | 5.86 | 8 | Yes | Yes | 7 | 0 | 2 | 1 | | A:A:R201 | O:O:?1 | 9.76 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:K293 | A:A:N292 | 4.2 | 8 | No | Yes | 9 | 9 | 2 | 2 | | A:A:A366 | A:A:N292 | 4.69 | 8 | Yes | Yes | 9 | 9 | 2 | 2 | | A:A:N292 | O:O:?1 | 7.36 | 8 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:K293 | O:O:?1 | 16.62 | 8 | No | Yes | 9 | 0 | 2 | 1 | | A:A:C365 | O:O:?1 | 3.4 | 0 | No | Yes | 8 | 0 | 2 | 1 | | A:A:A366 | O:O:?1 | 4.22 | 8 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:V367 | O:O:?1 | 4.79 | 8 | No | Yes | 9 | 0 | 2 | 1 | | I:I:?402 | O:O:?1 | 2.85 | 0 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 2.85 | | Average Nodes In Shell | 16.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 19.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO3 | A | Amine | Adrenergic | Beta2 | Homo Sapiens | Constrained Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
|
A 2D representation of the interactions of MG in 8UO3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:G52 | O:O:?1 | 8.25 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D223 | A:A:K53 | 4.15 | 0 | No | No | 9 | 9 | 2 | 2 | | A:A:K53 | O:O:?1 | 11.33 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D223 | A:A:S54 | 2.94 | 0 | No | No | 9 | 9 | 2 | 1 | | A:A:S54 | I:I:?402 | 5.78 | 4 | No | No | 9 | 0 | 1 | 0 | | A:A:S54 | O:O:?1 | 3.22 | 4 | No | Yes | 9 | 0 | 1 | 1 | | A:A:T55 | O:O:?1 | 5.53 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:D173 | A:A:K293 | 5.53 | 4 | No | Yes | 9 | 9 | 2 | 2 | | A:A:D173 | O:O:?1 | 2.91 | 4 | No | Yes | 9 | 0 | 2 | 1 | | A:A:R201 | O:O:?1 | 5.86 | 0 | No | Yes | 9 | 0 | 2 | 1 | | A:A:F208 | A:A:T204 | 3.89 | 0 | No | No | 5 | 9 | 2 | 1 | | A:A:T204 | I:I:?402 | 8.51 | 0 | No | No | 9 | 0 | 1 | 0 | | A:A:K293 | O:O:?1 | 6.8 | 4 | Yes | Yes | 9 | 0 | 2 | 1 | | A:A:C365 | A:A:D295 | 4.67 | 4 | No | No | 8 | 9 | 2 | 2 | | A:A:D295 | O:O:?1 | 4.36 | 4 | No | Yes | 9 | 0 | 2 | 1 | | A:A:C365 | O:O:?1 | 3.4 | 4 | No | Yes | 8 | 0 | 2 | 1 | | A:A:V367 | O:O:?1 | 7.98 | 4 | No | Yes | 9 | 0 | 2 | 1 | | I:I:?402 | O:O:?1 | 5.71 | 4 | No | Yes | 0 | 0 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.67 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO4 | A | Amine | Adrenergic | Beta2 | Homo Sapiens | Constrained Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
|
A 2D representation of the interactions of MG in 8UO4
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | A:A:D223 | A:A:V224 | 4.38 | 0 | No | No | 9 | 9 | 2 | 1 | | A:A:V224 | I:I:?402 | 2.87 | 0 | No | No | 9 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.87 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
