psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y75	8.06	Yes	Yes	0	0	7
2	L:L:?1	R:R:Q124	8.32	Yes	No	0	0	6
3	L:L:?1	R:R:D147	16.96	Yes	No	2	0	6
4	L:L:?1	R:R:Y148	12.45	Yes	No	0	0	4
5	L:L:?1	R:R:M151	3.53	Yes	Yes	0	0	7
6	L:L:?1	R:R:I296	6.24	Yes	No	0	0	6
7	L:L:?1	R:R:H297	4.02	Yes	Yes	0	0	8
8	L:L:?1	R:R:I322	7.14	Yes	No	0	0	5
9	L:L:?1	R:R:Y326	12.45	Yes	No	2	0	7
10	R:R:I69	R:R:T70	3.04	No	No	0	4	4
11	R:R:I71	R:R:Y128	9.67	No	No	3	4	5
12	R:R:H319	R:R:I71	11.93	Yes	No	3	4	4
13	R:R:A323	R:R:L74	3.15	No	No	0	4	5
14	R:R:S125	R:R:Y75	5.09	No	Yes	0	6	7
15	R:R:H319	R:R:Y75	15.24	Yes	Yes	0	4	7
16	R:R:C79	R:R:L83	3.17	No	No	0	6	6
17	R:R:C79	R:R:L121	7.94	No	Yes	0	6	7
18	R:R:C330	R:R:G82	3.92	No	No	0	7	8
19	R:R:L83	R:R:T118	2.95	No	No	0	6	6
20	R:R:L83	R:R:S119	6.01	No	No	0	6	5
21	R:R:D114	R:R:N86	6.73	Yes	No	0	9	9
22	R:R:A115	R:R:N86	4.69	No	No	0	7	9
23	R:R:N86	R:R:P333	4.89	No	No	0	9	9
24	R:R:P333	R:R:V89	3.53	No	Yes	0	9	9
25	R:R:A337	R:R:V89	3.39	No	Yes	0	7	9
26	R:R:F338	R:R:V89	3.93	No	Yes	0	6	9
27	R:R:F108	R:R:M90	3.73	No	No	0	6	7
28	R:R:L112	R:R:M90	5.65	No	No	0	6	7
29	R:R:R95	R:R:Y91	3.09	No	No	0	4	4
30	R:R:I93	R:R:M99	4.37	No	No	5	7	7
31	R:R:F108	R:R:I93	3.77	No	No	5	6	7
32	R:R:N104	R:R:T97	5.85	No	No	0	8	6
33	R:R:F343	R:R:T97	6.49	No	No	0	9	6
34	R:R:I105	R:R:M99	2.92	Yes	No	0	6	7
35	R:R:F108	R:R:M99	8.71	No	No	5	6	7
36	R:R:K100	R:R:P181	5.02	No	No	0	6	1
37	R:R:I107	R:R:T103	3.04	No	No	0	8	8
38	R:R:A184	R:R:I105	4.87	No	Yes	0	7	6
39	R:R:I105	R:R:K185	4.36	Yes	No	0	6	2
40	R:R:I105	R:R:N188	2.83	Yes	No	0	6	7
41	R:R:T160	R:R:Y106	3.75	No	Yes	0	7	7
42	R:R:M161	R:R:Y106	4.79	No	Yes	0	8	7
43	R:R:A184	R:R:Y106	5.34	No	Yes	0	7	7
44	R:R:V187	R:R:Y106	3.79	No	Yes	0	5	7
45	R:R:N188	R:R:Y106	3.49	No	Yes	0	7	7
46	R:R:N109	R:R:T157	4.39	No	No	0	9	7
47	R:R:N109	R:R:N188	13.62	No	No	0	9	7
48	R:R:N109	R:R:W192	11.3	No	Yes	0	9	9
49	R:R:D114	R:R:L110	8.14	Yes	No	4	9	9
50	R:R:L110	R:R:T157	5.9	No	No	0	9	7
51	R:R:L110	R:R:N332	5.49	No	Yes	4	9	9
52	R:R:D114	R:R:S154	5.89	Yes	No	0	9	9
53	R:R:D114	R:R:S329	7.36	Yes	No	0	9	9
54	R:R:D114	R:R:N332	6.73	Yes	Yes	4	9	9
55	R:R:L116	R:R:N150	5.49	No	Yes	0	7	8
56	R:R:L121	R:R:T118	4.42	Yes	No	0	7	6
57	R:R:I146	R:R:T120	3.04	No	No	0	5	6
58	R:R:L121	R:R:Y326	8.21	Yes	No	0	7	7
59	R:R:F123	R:R:F135	9.65	No	Yes	1	6	7
60	R:R:F123	R:R:V143	3.93	No	No	0	6	5
61	R:R:N127	R:R:Q124	6.6	No	No	0	6	6
62	R:R:N127	R:R:W133	7.91	No	Yes	0	6	8
63	R:R:H319	R:R:Y128	7.62	Yes	No	3	4	5
64	R:R:M130	R:R:P134	6.71	No	No	0	3	4
65	R:R:S214	R:R:T132	6.4	No	No	0	2	5
66	R:R:I215	R:R:T132	4.56	Yes	No	0	4	5
67	R:R:P134	R:R:W133	4.05	No	Yes	1	4	8
68	R:R:F135	R:R:W133	17.04	Yes	Yes	1	7	8
69	R:R:C140	R:R:W133	3.92	No	Yes	1	9	8
70	R:R:T208	R:R:W133	3.64	Yes	Yes	1	5	8
71	R:R:I215	R:R:W133	4.7	Yes	Yes	1	4	8
72	R:R:C217	R:R:W133	19.59	No	Yes	1	9	8
73	R:R:F135	R:R:P134	7.22	Yes	No	1	7	4
74	R:R:K141	R:R:N137	8.39	No	No	0	6	1
75	R:R:N137	R:R:T208	7.31	No	Yes	0	1	5
76	R:R:C140	R:R:T208	3.38	No	Yes	1	9	5
77	R:R:C140	R:R:C217	7.28	No	No	1	9	9
78	R:R:I144	R:R:V143	3.07	No	No	0	5	5
79	R:R:A206	R:R:I144	4.87	No	No	7	4	5
80	R:R:I144	R:R:L219	2.85	No	No	7	5	5
81	R:R:S145	R:R:V202	3.23	No	No	0	6	5
82	R:R:M203	R:R:S145	6.13	No	No	0	4	6
83	R:R:I146	R:R:N150	2.83	No	Yes	0	5	8
84	R:R:D147	R:R:Y326	5.75	No	No	2	6	7
85	R:R:N150	R:R:Y149	4.65	Yes	Yes	6	8	4
86	R:R:W192	R:R:Y149	8.68	Yes	Yes	6	9	4
87	R:R:S195	R:R:Y149	7.63	No	Yes	0	8	4
88	R:R:S196	R:R:Y149	3.82	No	Yes	0	3	4
89	R:R:G199	R:R:Y149	4.35	No	Yes	0	7	4
90	R:R:N150	R:R:W192	3.39	Yes	Yes	6	8	9
91	R:R:F152	R:R:M151	3.73	No	Yes	0	7	7
92	R:R:M151	R:R:W293	3.49	Yes	Yes	0	7	8
93	R:R:F152	R:R:F156	3.22	No	No	0	7	6
94	R:R:T153	R:R:W192	15.77	No	Yes	0	7	9
95	R:R:S195	R:R:T153	6.4	No	No	0	8	7
96	R:R:I155	R:R:P244	3.39	No	No	0	8	9
97	R:R:I155	R:R:W293	3.52	No	Yes	0	8	8
98	R:R:F156	R:R:N191	3.62	No	No	0	6	7
99	R:R:L158	R:R:N332	5.49	No	Yes	0	8	9
100	R:R:L158	R:R:Y336	4.69	No	No	0	8	9
101	R:R:C159	R:R:P244	3.77	No	No	0	7	9
102	R:R:C159	R:R:I247	3.27	No	No	0	7	7
103	R:R:M161	R:R:Y336	7.18	No	No	0	8	9
104	R:R:I248	R:R:S162	3.1	No	No	0	8	9
105	R:R:C251	R:R:S162	3.44	No	No	0	7	9
106	R:R:S162	R:R:Y252	10.17	No	Yes	0	9	9
107	R:R:D164	R:R:R179	14.29	No	No	0	8	6
108	R:R:R165	R:R:Y252	5.14	No	Yes	0	9	9
109	R:R:C170	R:R:Y166	8.06	No	Yes	0	7	8
110	R:R:H171	R:R:Y166	4.36	No	Yes	0	6	8
111	R:R:C251	R:R:Y166	6.72	No	Yes	0	7	8
112	R:R:L254	R:R:Y166	7.03	No	Yes	0	4	8
113	R:R:A168	R:R:R179	5.53	No	No	0	8	6
114	R:R:L259	R:R:V169	2.98	Yes	No	0	8	8
115	R:R:N183	R:R:T180	5.85	No	No	0	4	7
116	R:R:N183	R:R:R182	4.82	No	No	0	4	3
117	R:R:I186	R:R:R182	6.26	No	No	0	3	3
118	R:R:F221	R:R:M205	4.98	Yes	No	0	5	4
119	R:R:A206	R:R:L219	3.15	No	No	7	4	5
120	R:R:T207	R:R:T220	7.85	No	No	0	5	4
121	R:R:I215	R:R:T208	7.6	Yes	Yes	1	4	5
122	R:R:K209	R:R:T218	3	No	No	0	3	3
123	R:R:K209	R:R:T220	7.51	No	No	0	3	4
124	R:R:I215	R:R:Y210	4.84	Yes	No	0	4	1
125	R:R:D216	R:R:R211	3.57	No	No	0	4	3
126	R:R:G213	R:R:Q212	6.58	No	No	0	3	5
127	R:R:D216	R:R:T218	8.67	No	No	0	4	3
128	R:R:F221	R:R:L219	7.31	Yes	No	0	5	5
129	R:R:F221	R:R:W228	3.01	Yes	No	0	5	3
130	R:R:H223	R:R:P224	4.58	No	No	0	4	1
131	R:R:P224	R:R:Y227	5.56	No	No	0	1	3
132	R:R:E229	R:R:K233	4.05	No	No	0	4	4
133	R:R:C235	R:R:L231	3.17	No	No	0	3	4
134	R:R:K233	R:R:V300	4.55	No	No	0	4	5
135	R:R:F237	R:R:H297	3.39	No	Yes	0	5	8
136	R:R:F237	R:R:I301	5.02	No	No	0	5	6
137	R:R:F239	R:R:I238	11.3	No	No	0	4	4
138	R:R:F241	R:R:I242	3.77	No	No	0	8	5
139	R:R:F241	R:R:T294	7.78	No	No	0	8	5
140	R:R:F241	R:R:H297	5.66	No	Yes	0	8	8
141	R:R:I242	R:R:L246	2.85	No	No	0	5	3
142	R:R:M243	R:R:P244	3.35	No	No	0	5	9
143	R:R:F289	R:R:I248	3.77	No	No	0	9	8
144	R:R:L254	R:R:V250	2.98	No	No	0	4	4
145	R:R:M255	R:R:Y252	3.59	No	Yes	0	8	9
146	R:R:V282	R:R:Y252	7.57	No	Yes	0	7	9
147	R:R:L259	R:R:M255	4.24	Yes	No	0	8	8
148	R:R:I256	R:R:T279	4.56	No	No	0	5	6
149	R:R:I256	R:R:V282	4.61	No	No	0	5	7
150	R:R:M264	R:R:V262	3.04	No	No	0	5	6
151	R:R:L265	R:R:L275	4.15	No	No	0	3	6
152	R:R:K271	R:R:S268	4.59	No	No	0	4	4
153	R:R:E270	R:R:R273	8.14	No	No	0	2	4
154	R:R:E270	R:R:N274	5.26	No	No	0	2	5
155	R:R:N274	R:R:R277	4.82	No	No	0	5	7
156	R:R:R276	R:R:R280	11.73	No	No	0	5	6
157	R:R:E341	R:R:R277	6.98	No	No	0	4	7
158	R:R:V285	R:R:Y336	6.31	No	No	0	8	9
159	R:R:L335	R:R:V288	4.47	No	No	0	8	6
160	R:R:F289	R:R:W293	3.01	No	Yes	0	9	8
161	R:R:C292	R:R:N328	6.3	No	No	0	8	9
162	R:R:H297	R:R:W293	4.23	Yes	Yes	0	8	8
163	R:R:N328	R:R:W293	9.04	No	Yes	0	9	8
164	R:R:P295	R:R:T294	3.5	No	No	0	9	5
165	R:R:K303	R:R:Y299	4.78	No	Yes	8	4	4
166	R:R:S317	R:R:Y299	6.36	No	Yes	0	5	4
167	R:R:W318	R:R:Y299	7.72	No	Yes	8	5	4
168	R:R:I308	R:R:K303	2.91	No	No	0	1	4
169	R:R:K303	R:R:W318	5.8	No	No	8	4	5
170	R:R:I308	R:R:P309	5.08	No	No	0	1	3
171	R:R:I308	R:R:Q314	15.1	No	No	0	1	4
172	R:R:E310	R:R:Q314	10.19	No	No	0	1	4
173	R:R:T311	R:R:T312	4.71	No	No	0	1	4
174	R:R:I322	R:R:W318	9.4	No	No	0	5	5
175	R:R:L324	R:R:T327	2.95	No	No	0	7	5
176	R:R:N328	R:R:N332	12.26	No	Yes	0	9	9
177	R:R:K344	R:R:L339	5.64	No	No	0	8	6
178	R:R:D340	R:R:N342	8.08	No	No	0	8	6
179	R:R:C170	R:R:R258	2.79	No	No	0	7	5
180	R:R:A115	R:R:F87	2.77	No	No	0	7	4
181	R:R:A175	R:R:R179	2.77	No	No	0	6	6
182	R:R:L259	R:R:L265	2.77	Yes	No	0	8	3
183	R:R:A337	R:R:F343	2.77	No	No	0	7	9
184	R:R:H319	R:R:T315	2.74	Yes	No	0	4	4
185	R:R:C321	R:R:Y299	2.69	No	Yes	0	6	4
186	R:R:R95	R:R:V92	2.62	No	No	0	4	7
187	R:R:F135	R:R:V126	2.62	Yes	No	0	7	5
188	R:R:F289	R:R:V245	2.62	No	No	0	9	6
189	R:R:F313	R:R:T311	2.59	No	No	0	2	1
190	R:R:V202	R:R:Y148	2.52	No	No	0	5	4
191	R:R:F152	R:R:I198	2.51	No	No	0	7	4
192	R:R:M281	R:R:R277	2.48	No	No	0	8	7
193	R:R:S222	R:R:W228	2.47	No	No	0	6	3
194	R:R:F123	R:R:L139	2.44	No	No	1	6	6
195	R:R:F135	R:R:L139	2.44	Yes	No	1	7	6
196	R:R:D340	R:R:F343	2.39	No	No	0	8	9
197	R:R:L232	R:R:Y148	2.34	No	No	0	5	4
198	R:R:D164	R:R:Y106	2.3	No	Yes	0	8	7
199	R:R:N230	R:R:W226	2.26	No	No	0	3	2
200	R:R:R273	R:R:R276	2.13	No	No	0	4	5
201	R:R:W228	R:R:Y227	1.93	No	No	0	3	3
202	R:R:C79	R:R:P122	1.88	No	No	0	6	8
203	L:L:?1	R:R:V300	1.86	Yes	No	0	0	5
204	R:R:G267	R:R:S266	1.86	No	No	0	3	5
205	R:R:G82	R:R:T118	1.82	No	No	0	8	6
206	R:R:A102	R:R:A184	1.79	No	No	0	6	7
207	R:R:P181	R:R:T180	1.75	No	No	0	1	7
208	R:R:G267	R:R:K271	1.74	No	No	0	3	4
209	R:R:A113	R:R:S154	1.71	No	No	0	8	9
210	R:R:C251	R:R:V163	1.71	No	No	0	7	6
211	R:R:C292	R:R:V288	1.71	No	No	0	8	6
212	R:R:A111	R:R:V89	1.7	No	Yes	0	9	9
213	R:R:A240	R:R:V236	1.7	No	No	0	6	5
214	R:R:I105	R:R:P181	1.69	Yes	No	0	6	1
215	R:R:C190	R:R:I186	1.64	No	No	0	4	3
216	R:R:L200	R:R:P201	1.64	No	No	0	3	7
217	R:R:L324	R:R:P295	1.64	No	No	0	7	9
218	R:R:A337	R:R:I107	1.62	No	No	0	7	8
219	R:R:A175	R:R:I167	1.62	No	No	0	6	5
220	R:R:V80	R:R:V81	1.6	No	No	0	5	5
221	R:R:V284	R:R:V288	1.6	No	No	0	6	6
222	R:R:T97	R:R:V92	1.59	No	No	0	6	7
223	R:R:T249	R:R:V245	1.59	No	No	0	4	6
224	R:R:T101	R:R:T103	1.57	No	No	0	8	8
225	R:R:A117	R:R:N150	1.56	No	Yes	0	7	8
226	R:R:I290	R:R:V245	1.54	No	No	0	5	6
227	R:R:I290	R:R:V286	1.54	No	No	0	5	8
228	R:R:H171	R:R:P172	1.53	No	No	0	6	7
229	R:R:K269	R:R:S268	1.53	No	No	0	1	4
230	R:R:I71	R:R:T67	1.52	No	No	0	4	3
231	R:R:M151	R:R:V236	1.52	Yes	No	0	7	5
232	R:R:K174	R:R:V173	1.52	No	No	0	4	5
233	R:R:I298	R:R:T294	1.52	No	No	0	6	5
234	R:R:F84	R:R:G85	1.51	No	No	0	4	7
235	R:R:K141	R:R:T207	1.5	No	No	0	6	5
236	R:R:L200	R:R:S196	1.5	No	No	0	3	3
237	R:R:L121	R:R:V78	1.49	Yes	No	0	7	7
238	R:R:L88	R:R:V92	1.49	No	No	0	6	7
239	R:R:L335	R:R:V334	1.49	No	No	0	8	6
240	R:R:L339	R:R:V334	1.49	No	No	0	6	6
241	R:R:I142	R:R:I146	1.47	No	No	0	5	5
242	R:R:I234	R:R:I238	1.47	No	No	0	4	4
243	R:R:I298	R:R:I302	1.47	No	No	0	6	5
244	R:R:I302	R:R:I306	1.47	No	No	0	5	3
245	R:R:L331	R:R:T327	1.47	No	No	0	7	5
246	R:R:I69	R:R:M72	1.46	No	No	0	4	5
247	R:R:E270	R:R:S268	1.44	No	No	0	2	4
248	R:R:I278	R:R:L259	1.43	No	Yes	0	7	8
249	R:R:Q314	R:R:T311	1.42	No	No	0	4	1
250	R:R:L129	R:R:M130	1.41	No	No	0	5	3
251	R:R:K260	R:R:L275	1.41	No	No	0	4	6
252	R:R:L339	R:R:M281	1.41	No	No	0	6	8
253	R:R:D177	R:R:L176	1.36	No	No	0	4	5
254	R:R:R258	R:R:S261	1.32	No	No	0	5	4
255	R:R:R95	R:R:V94	1.31	No	No	0	4	3
256	R:R:H171	R:R:K174	1.31	No	No	0	6	4
257	R:R:E229	R:R:N230	1.31	No	No	0	4	3
258	R:R:R258	R:R:V262	1.31	No	No	0	5	6
259	R:R:F221	R:R:T225	1.3	Yes	No	0	5	3
260	R:R:F237	R:R:I238	1.26	No	No	0	5	4
261	R:R:F204	R:R:M203	1.24	No	No	0	5	4
262	R:R:F320	R:R:L74	1.22	No	No	0	5	5
263	R:R:N342	R:R:R345	1.21	No	No	0	6	4
264	R:R:D177	R:R:F178	1.19	No	No	0	4	4
265	R:R:L74	R:R:Y75	1.17	No	Yes	0	5	7
266	R:R:I193	R:R:W192	1.17	No	Yes	0	4	9
267	R:R:Q212	R:R:R211	1.17	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.103	10	2	0
2	R:R:Y75	7.39	4	0	7
3	R:R:V89	3.1375	4	0	9
4	R:R:I105	3.334	5	0	6
5	R:R:Y106	3.91	6	0	7
6	R:R:D114	6.97	5	4	9
7	R:R:L121	5.515	4	0	7
8	R:R:W133	8.69286	7	1	8
9	R:R:F135	7.794	5	1	7
10	R:R:Y149	5.826	5	6	4
11	R:R:N150	3.584	5	6	8
12	R:R:M151	3.0675	4	0	7
13	R:R:Y166	6.5425	4	0	8
14	R:R:W192	8.062	5	6	9
15	R:R:T208	5.4825	4	1	5
16	R:R:I215	5.425	4	1	4
17	R:R:F221	4.15	4	0	5
18	R:R:Y252	6.6175	4	0	9
19	R:R:L259	2.855	4	0	8
20	R:R:W293	4.658	5	0	8
21	R:R:H297	4.325	4	0	8
22	R:R:Y299	5.3875	4	8	4
23	R:R:H319	9.3825	4	3	4
24	R:R:N332	7.4925	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y75	16.2097	8.06	Yes	Yes	0	0	7
2	L:L:?1	R:R:Y326	19.2956	12.45	Yes	No	2	0	7
3	R:R:L121	R:R:Y326	17.7832	8.21	Yes	No	0	7	7
4	L:L:?1	R:R:M151	54.9754	3.53	Yes	Yes	0	0	7
5	R:R:M151	R:R:W293	56.405	3.49	Yes	Yes	0	7	8
6	R:R:N328	R:R:W293	100	9.04	No	Yes	0	9	8
7	R:R:N328	R:R:N332	84.9889	12.26	No	Yes	0	9	9
8	R:R:D114	R:R:N332	31.1598	6.73	Yes	Yes	4	9	9
9	L:L:?1	R:R:H297	58.8153	4.02	Yes	Yes	0	0	8
10	R:R:H297	R:R:W293	62.2979	4.23	Yes	Yes	0	8	8
11	R:R:D114	R:R:N86	31.1598	6.73	Yes	No	0	9	9
12	R:R:N86	R:R:P333	27.1586	4.89	No	No	0	9	9
13	R:R:P333	R:R:V89	25.8074	3.53	No	Yes	0	9	9
14	R:R:A337	R:R:V89	21.7016	3.39	No	Yes	0	7	9
15	R:R:L110	R:R:N332	38.7787	5.49	No	Yes	4	9	9
16	R:R:L110	R:R:T157	42.9194	5.9	No	No	0	9	7
17	R:R:N109	R:R:T157	41.8472	4.39	No	No	0	9	7
18	R:R:N109	R:R:N188	22.5821	13.62	No	No	0	9	7
19	R:R:I105	R:R:N188	19.8623	2.83	Yes	No	0	6	7
20	R:R:A337	R:R:F343	16.1051	2.77	No	No	0	7	9
21	R:R:F343	R:R:T97	10.3692	6.49	No	No	0	9	6
22	R:R:I105	R:R:P181	10.3692	1.69	Yes	No	0	6	1
23	R:R:L158	R:R:N332	17.6132	5.49	No	Yes	0	8	9
24	R:R:L158	R:R:Y336	16.4625	4.69	No	No	0	8	9
25	R:R:M161	R:R:Y336	14.4314	7.18	No	No	0	8	9
26	R:R:M161	R:R:Y106	13.4115	4.79	No	Yes	0	8	7
27	R:R:N109	R:R:W192	22.3816	11.3	No	Yes	0	9	9
28	L:L:?1	R:R:Q124	58.301	8.32	Yes	No	0	0	6
29	R:R:N127	R:R:Q124	56.9716	6.6	No	No	0	6	6
30	R:R:N127	R:R:W133	55.6335	7.91	No	Yes	0	6	8
31	R:R:F135	R:R:W133	25.3106	17.04	Yes	Yes	1	7	8
32	R:R:F123	R:R:F135	20.8473	9.65	No	Yes	1	6	7
33	R:R:F123	R:R:V143	19.3479	3.93	No	No	0	6	5
34	R:R:T208	R:R:W133	17.5435	3.64	Yes	Yes	1	5	8
35	R:R:N137	R:R:T208	16.2533	7.31	No	Yes	0	1	5
36	R:R:K141	R:R:N137	14.6668	8.39	No	No	0	6	1
37	R:R:I144	R:R:V143	17.7832	3.07	No	No	0	5	5
38	R:R:I144	R:R:L219	14.5883	2.85	No	No	7	5	5
39	R:R:F289	R:R:W293	43.4337	3.01	No	Yes	0	9	8
40	R:R:F289	R:R:I248	37.4624	3.77	No	No	0	9	8
41	R:R:I248	R:R:S162	36.242	3.1	No	No	0	8	9
42	R:R:C251	R:R:S162	19.5833	3.44	No	No	0	7	9
43	R:R:S162	R:R:Y252	16.8897	10.17	No	Yes	0	9	9
44	R:R:C251	R:R:Y166	16.8897	6.72	No	Yes	0	7	8
45	R:R:M255	R:R:Y252	10.0031	3.59	No	Yes	0	8	9
46	R:R:F221	R:R:L219	13.0367	7.31	Yes	No	0	5	5
47	R:R:K141	R:R:T207	13.0715	1.5	No	No	0	6	5
48	R:R:T207	R:R:T220	11.4676	7.85	No	No	0	5	4
49	R:R:F241	R:R:H297	11.6463	5.66	No	Yes	0	8	8
50	R:R:C292	R:R:N328	27.455	6.3	No	No	0	8	9
51	R:R:C292	R:R:V288	26.1648	1.71	No	No	0	8	6
52	R:R:L335	R:R:V288	23.5584	4.47	No	No	0	8	6
53	R:R:L335	R:R:V334	22.2421	1.49	No	No	0	8	6
54	R:R:L339	R:R:V334	20.9171	1.49	No	No	0	6	6
55	R:R:L339	R:R:M281	18.2409	1.41	No	No	0	6	8
56	R:R:M281	R:R:R277	16.8897	2.48	No	No	0	8	7
57	R:R:N274	R:R:R277	14.1612	4.82	No	No	0	5	7
58	R:R:E270	R:R:N274	12.7839	5.26	No	No	0	2	5
59	L:L:?1	R:R:I322	20.904	7.14	Yes	No	0	0	5
60	R:R:I322	R:R:W318	19.3479	9.4	No	No	0	5	5
61	R:R:K303	R:R:W318	12.932	5.8	No	No	8	4	5
62	R:R:I308	R:R:K303	11.437	2.91	No	No	0	1	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y75	8.06	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:Q124	8.32	2	Yes	No	0	6	0	1
L:L:?1	R:R:D147	16.96	2	Yes	No	0	6	0	1
L:L:?1	R:R:Y148	12.45	2	Yes	No	0	4	0	1
L:L:?1	R:R:M151	3.53	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:I296	6.24	2	Yes	No	0	6	0	1
L:L:?1	R:R:H297	4.02	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:I322	7.14	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y326	12.45	2	Yes	No	0	7	0	1
R:R:S125	R:R:Y75	5.09	0	No	Yes	6	7	2	1
R:R:H319	R:R:Y75	15.24	3	Yes	Yes	4	7	2	1
R:R:L121	R:R:Y326	8.21	0	Yes	No	7	7	2	1
R:R:N127	R:R:Q124	6.6	0	No	No	6	6	2	1
R:R:D147	R:R:Y326	5.75	2	No	No	6	7	1	1
R:R:F152	R:R:M151	3.73	0	No	Yes	7	7	2	1
R:R:M151	R:R:W293	3.49	0	Yes	Yes	7	8	1	2
R:R:K233	R:R:V300	4.55	0	No	No	4	5	2	1
R:R:F237	R:R:H297	3.39	0	No	Yes	5	8	2	1
R:R:F241	R:R:H297	5.66	0	No	Yes	8	8	2	1
R:R:H297	R:R:W293	4.23	0	Yes	Yes	8	8	1	2
R:R:I322	R:R:W318	9.4	0	No	No	5	5	1	2
R:R:V202	R:R:Y148	2.52	0	No	No	5	4	2	1
R:R:L232	R:R:Y148	2.34	0	No	No	5	4	2	1
L:L:?1	R:R:V300	1.86	2	Yes	No	0	5	0	1
R:R:M151	R:R:V236	1.52	0	Yes	No	7	5	1	2
R:R:L74	R:R:Y75	1.17	0	No	Yes	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ODJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	256
Number of Links	267
Number of Hubs	24
Number of Links mediated by Hubs	100
Number of Communities	8
Number of Nodes involved in Communities	30
Number of Links involved in Communities	34

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	42638
Length Of Smallest Path	3
Average Path Length	13.2722
Length of Longest Path	31
Minimum Path Strength	1.195
Average Path Strength	5.74418
Maximum Path Strength	18.315
Minimum Path Correlation	0.7
Average Path Correlation	0.968549
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	10
Average % Of Corr. Nodes	72.3183
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4442
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • binding • neuropeptide binding • peptide binding • protein binding • G-protein alpha-subunit binding • peptide receptor activity • molecular transducer activity • beta-endorphin receptor activity • G protein-coupled opioid receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled peptide receptor activity • melanocortin receptor activity • neuropeptide receptor activity • morphine receptor activity • protein domain specific binding • calcium channel activity • monoatomic cation transmembrane transporter activity • voltage-gated calcium channel activity • gated channel activity • monoatomic ion channel activity • voltage-gated channel activity • voltage-gated monoatomic ion channel activity • voltage-gated monoatomic cation channel activity • monoatomic cation channel activity • passive transmembrane transporter activity • calcium ion transmembrane transporter activity • channel activity • monoatomic ion transmembrane transporter activity • transporter activity • metal ion transmembrane transporter activity • transmembrane transporter activity • G-protein beta-subunit binding • trans-synaptic signaling • regulation of biological process • regulation of signaling • regulation of cellular process • modulation of chemical synaptic transmission • signaling • biological regulation • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • cell communication • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • cellular process • cellular response to stimulus • response to stimulus • G protein-coupled opioid receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multi-multicellular organism process • multicellular organismal process • sperm ejaculation • reproductive process • multicellular organismal reproductive process • mating behavior • behavior • reproductive behavior • insemination • multi-organism reproductive process • copulation • system process • nervous system process • transmission of nerve impulse • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of biological quality • negative regulation of cytosolic calcium ion concentration • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of response to stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of nervous system development • regulation of developmental process • cellular developmental process • positive regulation of biological process • cell development • regulation of cell differentiation • regulation of neurogenesis • regulation of cell development • regulation of nervous system development • positive regulation of developmental process • multicellular organism development • neurogenesis • positive regulation of cell differentiation • cell differentiation • anatomical structure development • positive regulation of neurogenesis • regulation of multicellular organismal process • positive regulation of cellular process • system development • developmental process • regulation of multicellular organismal development • positive regulation of cell development • nervous system development • positive regulation of multicellular organismal process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • neuropeptide signaling pathway • monosaccharide metabolic process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • locomotory behavior • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • regulation of localization • transport • regulation of signaling receptor activity • regulation of transmembrane transporter activity • localization • regulation of NMDA receptor activity • regulation of transport • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • regulation of neurotransmitter receptor activity • negative regulation of luteinizing hormone secretion • regulation of system process • negative regulation of transport • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of hormone levels • regulation of secretion • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • secretion • regulation of gonadotropin secretion • export from cell • endocrine process • hormone transport • eating behavior • feeding behavior • regulation of cellular response to stress • cellular response to stress • regulation of response to stress • response to stress • adenylate cyclase-inhibiting opioid receptor signaling pathway • regulation of nitric oxide biosynthetic process • negative regulation of metabolic process • reactive nitrogen species metabolic process • nitric oxide metabolic process • nitric oxide biosynthetic process • negative regulation of nitric oxide biosynthetic process • negative regulation of biosynthetic process • regulation of nitric oxide metabolic process • response to nutrient levels • regulation of response to nutrient levels • positive regulation of appetite • regulation of response to food • response to food • positive regulation of response to food • regulation of appetite • positive regulation of response to nutrient levels • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • cell surface receptor signaling pathway • excitatory postsynaptic potential • regulation of membrane potential • biological process involved in intraspecies interaction between organisms • social behavior • sensory perception • sensory perception of pain • negative regulation of protein transport • establishment of protein localization • regulation of protein localization • negative regulation of Wnt protein secretion • protein localization to extracellular region • intracellular protein localization • regulation of Wnt protein secretion • negative regulation of protein localization • establishment of protein localization to extracellular region • regulation of establishment of protein localization • negative regulation of establishment of protein localization • regulation of protein transport • Wnt protein secretion • protein secretion • regulation of protein secretion • negative regulation of protein secretion • protein transport • macromolecule localization • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • sarcolemma • T-tubule • somatodendritic compartment • cell body • perikaryon • neuronal cell body • presynapse • presynaptic membrane • dendrite • dendritic tree • neuron projection • sarcoplasm • endoplasmic reticulum • sarcoplasmic reticulum • axon • mitochondrion • anchoring junction • focal adhesion • cell-substrate junction • GABA-ergic synapse • neuron projection cytoplasm • dendrite cytoplasm • cell leading edge • leading edge membrane • neuron projection membrane • dendrite membrane • cell projection membrane • endosome • intracellular vesicle • cytoplasmic vesicle • neuron spine • dendritic spine • spine apparatus • fibroblast proliferation • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Galpha insert domain-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Galpha insert domain-like • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	MG
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	MG
Name	MAGNESIUM ION
Synonyms
Identifier
Formula	Mg
Molecular Weight	24.305
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


Code	EIG
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	EIG
Name	Mitragynine pseudoindoxyl
Synonyms	methyl (2E)-4-[(2S,2'S)-1'-butyl-4-methoxy-3-oxo-1,3-dihydrospiro[indole-2,3'-pyrrolidin]-2'-yl]-2-(methoxymethylidene)butanoate
Identifier
Formula	C23 H30 N2 O5
Molecular Weight	414.495
SMILES
PubChem	44301701
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	4
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P42866
Sequence	>9ODJ_nogp_Chain_R T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T K M K T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T W P F G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H P V K A L D F R T P R N A K I V N V C N W I L S S A I G L P V M F M A T T K Y R Q G S I D C T L T F S H P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V R M L S G S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T I P E T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4DKL	A	Peptide	Opioid	μ	Mus musculus	β-Funaltrexamine	-	-	2.8	2012-03-21	doi.org/10.1038/nature10954
	5C1M	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.07	2015-08-05	doi.org/10.1038/nature14886
	6DDE	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDE (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-	Gi1/β1/γ2	3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	6DDF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	DAMGO	-		3.5	2018-06-13	doi.org/10.1038/s41586-018-0219-7
	7SBF	A	Peptide	Opioid	μ	Mus musculus	PZM21	-	Gi1/β1/γ2	2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SBF (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	PZM21	-		2.9	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG	A	Peptide	Opioid	μ	Mus musculus	FH210	-	Gi1/β1/γ2	3	2022-04-20	doi.org/10.1002/anie.202200269
	7SCG (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	FH210	-		3	2022-04-20	doi.org/10.1002/anie.202200269
	7U2L	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-	Gi1/β1/γ2	3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7U2L (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C5-guano	-		3.2	2022-05-04	doi.org/10.1038/s41586-022-05588-y
	7UL4	A	Peptide	Opioid	μ	Mus musculus	Alvimopan	-	-	2.8	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8EF5	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF5 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Fentanyl	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EF6 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Morphine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFB (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Oliceridine	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-	Gi1/β1/γ2	3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFL (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	SR17018	-		3.2	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-	Gi1/β1/γ2	2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFO (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	PZM21	-		2.8	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi1/β1/γ2	3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	8EFQ (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		3.3	2022-11-09	doi.org/10.1016/j.cell.2022.09.041
	7T2G	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2G (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-	Gi1/β1/γ2	2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7T2H (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Lofentanil	-		2.5	2022-12-07	doi.org/10.1038/s41589-022-01208-y
	7U2K	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-	Gi1/β1/γ2	3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	7U2K (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	C6-guano	-		3.3	2022-12-07	doi.org/10.1038/s41586-022-05588-y
	8F7Q	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-	Gi1/β1/γ2	3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7Q (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	β-Endorphin	-		3.22	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7R (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8K9K	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Gi3/β1/γ1	2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9K (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.98	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122	Gi3/β1/γ1	3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	8K9L (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	BMS-986122		3.05	2024-05-29	doi.org/10.1038/s41467-024-47792-6
	9BJK	A	Peptide	Opioid	μ	Mus musculus	Naloxone	PubChem 171642066	-	3.26	2024-07-17	doi.org/10.1038/s41586-024-07587-7
	9BQJ	A	Peptide	Opioid	μ	Mus musculus	RO76	-	Gi1/β1/γ2	3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9BQJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	RO76	-		3.3	2024-09-11	doi.org/10.1021/acscentsci.4c00525
	9MQH	A	Peptide	Opioid	μ	Homo sapiens	-	-	-	3.9	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQI	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.3	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9MQJ	A	Peptide	Opioid	μ	Homo sapiens	Isoquinuclidine	-	-	3.23	2025-02-12	doi.org/10.1101/2025.01.09.632033
	9WST	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WST (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	DAMGO	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	chim(NtGi1-Gz)/β1/γ2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-	Arrestin2	2.8	2025-11-26	10.1038/s41422-025-01191-8
	9WSX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Endomorphin	-		2.8	2025-11-26	10.1038/s41422-025-01191-8
	8E0G	A	Peptide	Opioid	μ	Mus musculus	BU72	-	-	2.1	2023-10-18	doi.org/10.1186/s12915-023-01689-w
	8QOT	A	Peptide	Opioid	μ	Mus musculus	Nanobody-E	-	-	3.2	2023-12-27	doi.org/10.1101/2023.12.06.570395
	8Y72	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122	Gi1/β1/γ2	2.65	2025-08-06	To be published
	8Y72 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	BMS-986122		2.65	2025-08-06	To be published
	8Y73	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15	Gi1/β1/γ2	2.84	2025-08-06	To be published
	8Y73 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Peptide	MPAM-15		2.84	2025-08-06	To be published
	9PXU	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	Na	-	3.4	2025-11-12	10.1038/s41586-025-09677-6
	9PXV	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-	Gi1/β1/γ2	3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXV (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	-		3.02	2025-11-12	10.1038/s41586-025-09677-6
	9PXW	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXW (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.8	2025-11-12	10.1038/s41586-025-09677-6
	9PXX	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXX (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3.1	2025-11-12	10.1038/s41586-025-09677-6
	9PXY	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS	Gi1/β1/γ2	3	2025-11-12	10.1038/s41586-025-09677-6
	9PXY (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Naloxone	GDPβS		3	2025-11-12	10.1038/s41586-025-09677-6
	9PY2	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY2 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.16	2025-11-12	10.1038/s41586-025-09677-6
	9PY3	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	3.2	2025-11-12	To be published
	9PY3 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		3.2	2025-11-12	To be published
	9PY4	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS	Gi1/β1/γ2	2.78	2025-11-12	10.1038/s41586-025-09677-6
	9PY4 (No Gprot)	A	Peptide	Opioid	μ	Homo sapiens	Loperamide	GDPβS		2.78	2025-11-12	10.1038/s41586-025-09677-6
	9ODJ	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3	2026-01-07	10.1038/s41586-025-10056-4
	9ODJ (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3	2026-01-07	10.1038/s41586-025-10056-4
	9ODK	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg	Gi1/β1/γ2	3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODK (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	-	GTP; Mg		3.9	2026-01-07	10.1038/s41586-025-10056-4
	9ODL	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg	Gi1/β1/γ2	3.6	2026-01-07	10.1038/s41586-025-10056-4
	9ODL (No Gprot)	A	Peptide	Opioid	μ	Mus musculus	Mitragynine Pseudoindoxyl	GTP; Mg		3.6	2026-01-07	10.1038/s41586-025-10056-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9ODJ_nogp.zip

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