Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 2.7925409
2A:A:R21 4.224184
3A:A:E25 2.50254184
4A:A:L36 3.6225407
5A:A:K46 4.382519
6A:A:Q52 5.595479
7A:A:I56 5.14477
8A:A:Y61 4.8025207
9A:A:Y69 6.8554205
10A:A:Y74 8.954514
11A:A:I85 4.16254154
12A:A:M88 6.92754157
13A:A:F95 14.9756154
14A:A:R100 12.9256155
15A:A:V126 7.624215
16A:A:I127 5.41754216
17A:A:L130 8.6354157
18A:A:W131 7.5125408
19A:A:D133 8.214158
20A:A:G135 3.135404
21A:A:V136 5.184156
22A:A:F140 3.542505
23A:A:Y146 7.876506
24A:A:Y154 7.312519
25A:A:Y155 4.232517
26A:A:R161 6.215618
27A:A:I162 3.1325417
28A:A:Y167 4.88667618
29A:A:I168 4.27413
30A:A:P169 6.2575419
31A:A:D173 6.045419
32A:A:R176 7.914516
33A:A:T177 3.6425406
34A:A:R178 5.2475409
35A:A:F189 6.515679
36A:A:F191 8.65167675
37A:A:F196 6.368577
38A:A:K197 7.264146
39A:A:M198 3.87477
40A:A:F199 7.72254145
41A:A:D200 3.86409
42A:A:K210 6.75754119
43A:A:H213 3.9725118
44A:A:F215 4.211437149
45A:A:I221 4.5125248
46A:A:I222 3.4154197
47A:A:Y230 4.598558
48A:A:M240 4.494296
49A:A:R242 9.224279
50A:A:F250 4.665409
51A:A:F259 5.7745249
52A:A:I265 3.0265198
53A:A:F267 3.3345199
54A:A:L268 7.3754288
55A:A:K270 8.35833619
56A:A:L273 5.44416
57A:A:F274 5.4675459
58A:A:L283 5.4025457
59A:A:C286 6.36556
60A:A:Y287 5.58375857
61A:A:Y296 5.356504
62A:A:Y302 8.2456
63A:A:F307 5.282558
64A:A:Y320 4.568336197
65A:A:F323 4.7254284
66A:A:F336 3.9275478
67A:A:T340 4.06576
68B:B:A11 2.25254325
69B:B:I18 4.09407
70B:B:M45 3.185404
71B:B:R49 3.54437
72B:B:L51 3.545439
73B:B:H54 6.51857739
74B:B:I58 4.4125439
75B:B:Y59 9.7554118
76B:B:M61 4.4825436
77B:B:W63 6.722537
78B:B:R68 9.96754255
79B:B:L70 4.6675435
80B:B:V71 5.715408
81B:B:S74 5.8875439
82B:B:D76 8.435439
83B:B:L79 4.24754127
84B:B:W82 6.80286739
85B:B:D83 4.68754258
86B:B:Y85 8.86754254
87B:B:K89 4.8075409
88B:B:I93 7.9054127
89B:B:L95 3.5654128
90B:B:W99 7.263336149
91B:B:Y105 4.625606
92B:B:Y111 6.5825404
93B:B:C114 3.48754128
94B:B:Y124 6.178336126
95B:B:N125 5.58404
96B:B:E138 4.31754126
97B:B:L139 4.8975409
98B:B:H142 6.5425179
99B:B:Y145 5.95118
100B:B:F151 4.97833609
101B:B:T159 4.9975409
102B:B:S161 7.41754179
103B:B:D163 8.42754179
104B:B:T165 4.1425177
105B:B:W169 8.3545178
106B:B:F180 5.695687
107B:B:H183 6.04429789
108B:B:V187 4.72489
109B:B:F199 5.144589
110B:B:V200 4.1775406
111B:B:S201 4.6075489
112B:B:C204 6.375407
113B:B:D205 5.878589
114B:B:K209 10.7775486
115B:B:W211 6.47833688
116B:B:E215 4.6254343
117B:B:F222 7.902528
118B:B:H225 7.32857729
119B:B:I232 3.13628
120B:B:F234 4.265405
121B:B:F235 6.371437226
122B:B:P236 6.0454227
123B:B:N237 6.5845225
124B:B:F241 5.42626
125B:B:T243 4.386528
126B:B:D247 5.696529
127B:B:T249 3.9426
128B:B:R251 10.112528
129B:B:F253 6.522526
130B:B:L255 4.1275426
131B:B:D258 9.765427
132B:B:E260 7.055426
133B:B:Y264 4.2225405
134B:B:H266 12.486594
135B:B:I269 10.8875494
136B:B:C271 5.9175405
137B:B:F278 5.791676227
138B:B:R283 6.28754369
139B:B:L284 3.89254365
140B:B:L286 3.30754357
141B:B:Y289 7.745697
142B:B:N295 6.99596
143B:B:L300 3.3925406
144B:B:K301 3.64405
145B:B:W332 12.276119
146B:B:L336 3.2375437
147B:B:W339 10.814339
148G:G:L19 3.88754329
149G:G:Y40 4.61754226
150G:G:D48 5.228509
151G:G:L51 3.09254366
152G:G:F61 4.242508
153I:I:?1 6.365410
154O:O:?1 6.9181510
155R:R:L83 3.59754376
156R:R:L88 3.796546
157R:R:M99 8.452547
158R:R:K100 3.4175406
159R:R:N104 4.77333648
160R:R:I105 3.635406
161R:R:Y106 13.1445107
162R:R:L110 8.75754109
163R:R:L121 4.565407
164R:R:N127 3.68254136
165R:R:W133 4.73258138
166R:R:L139 5.7354136
167R:R:Y148 9.17254104
168R:R:F152 6.1854397
169R:R:T153 3.28754237
170R:R:I155 6.434108
171R:R:F156 4.9254396
172R:R:R165 8.934269
173R:R:Y166 8.4254168
174R:R:I167 5.0854165
175R:R:H171 6.18254166
176R:R:K174 9.3754164
177R:R:K209 7.37754383
178R:R:C217 4.4054139
179R:R:F221 6.85405
180R:R:W226 2.66254402
181R:R:I234 3.715404
182R:R:F237 8.92565
183R:R:P244 3.77409
184R:R:M255 8.3054268
185R:R:F289 7.9045109
186R:R:W293 6.9625108
187R:R:Y299 6.44667664
188R:R:I301 5.3625466
189R:R:I302 4.6465
190R:R:Q314 6.522564
191R:R:W318 7.452565
192R:R:L335 5.98754418
193R:R:Y336 4.24833649
194R:R:D340 6.748548
195R:R:N342 7.66546
196R:R:F343 9.56549
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 25.26973.24NoYes076
2B:B:C317 B:B:S316 25.47995.16NoNo079
3B:B:S316 B:B:W332 26.15662.47NoYes099
4B:B:R314 B:B:W332 60.406915.99NoYes1189
5B:B:D290 B:B:R314 60.96994.76NoNo068
6B:B:C271 B:B:D290 76.68719.34YesNo056
7B:B:C271 B:B:D291 62.38667.78YesNo058
8B:B:D291 B:B:N293 62.14234.04NoNo085
9B:B:N293 B:B:V307 61.71524.43NoNo953
10B:B:A309 B:B:V307 83.35781.7NoNo033
11B:B:A309 B:B:G310 83.16541.95NoNo035
12B:B:G310 R:R:Y96 82.97171.45NoNo055
13R:R:K98 R:R:Y96 82.779911.94NoNo055
14R:R:K98 R:R:N342 80.39582.8NoYes056
15R:R:N104 R:R:N342 63.772.72YesYes486
16R:R:F108 R:R:N104 12.93382.42NoYes068
17R:R:I107 R:R:N104 53.74182.83NoYes088
18R:R:I107 R:R:Y106 53.485412.09NoYes087
19R:R:L158 R:R:Y106 53.19745.86NoYes1087
20R:R:F289 R:R:L158 53.92287.31YesNo1098
21R:R:F289 R:R:I155 15.067212.56YesYes1098
22R:R:I155 R:R:P244 13.27983.39YesYes089
23A:A:H213 B:B:W332 64.64784.23YesYes1189
24A:A:C214 A:A:H213 64.53434.42NoYes078
25A:A:C214 A:A:F215 62.96522.79NoYes079
26A:A:F215 A:A:W211 1005.01YesNo1499
27A:A:R208 A:A:W211 99.86445NoNo099
28A:A:L249 A:A:R208 99.6414.86NoNo099
29A:A:F223 A:A:L249 99.4172.44NoNo099
30A:A:F223 A:A:V225 94.84572.62NoNo097
31A:A:L268 A:A:V225 81.16952.98YesNo087
32A:A:F323 A:A:L268 81.49158.53YesYes2848
33A:A:F323 A:A:Y296 81.06825.16YesYes044
34A:A:K271 A:A:Y296 79.82639.55NoYes054
35A:A:K271 A:A:N331 79.56482.8NoNo058
36A:A:N331 A:A:T324 22.68914.39NoNo089
37A:A:F267 A:A:T324 22.33172.59YesNo099
38A:A:F267 A:A:I222 17.51645.02YesYes1997
39A:A:I222 A:A:L36 11.04432.85YesYes077
40A:A:C325 O:O:?1 58.13543.4NoYes170
41A:A:C325 A:A:D328 59.45543.11NoNo079
42A:A:D328 A:A:N331 60.04655.39NoNo098
43A:A:R176 O:O:?1 44.99715.86YesYes160
44A:A:R176 A:A:Y155 38.1073.09YesYes167
45A:A:I162 A:A:Y155 31.97093.63YesYes177
46A:A:I162 A:A:L159 28.55262.85YesNo075
47A:A:I127 A:A:L159 26.82092.85YesNo065
48A:A:I127 A:A:I81 22.25538.83YesNo066
49A:A:I81 A:A:I85 21.54484.42NoYes064
50A:A:F307 A:A:V225 13.94987.87YesNo087
51A:A:H213 A:A:K210 34.69412.62YesYes1189
52A:A:K210 B:B:Y145 29.485814.33YesYes1198
53B:B:L117 B:B:Y145 38.54253.52NoYes098
54A:A:F215 B:B:L117 38.55822.44YesNo099
55A:A:S206 B:B:Y145 18.61816.36NoYes088
56A:A:S206 B:B:D186 18.3782.94NoNo089
57A:A:K210 B:B:M188 41.82497.2YesNo098
58B:B:C204 B:B:M188 56.60954.86YesNo078
59B:B:C204 B:B:D186 18.40939.34YesNo079
60B:B:C204 B:B:G185 73.44461.96YesNo075
61B:B:D205 B:B:G185 72.94943.35YesNo095
62B:B:D205 B:B:S207 51.728910.31YesNo895
63B:B:S207 B:B:T223 52.2071.6NoNo052
64B:B:G224 B:B:T223 51.68893.64NoNo062
65B:B:E260 B:B:G224 51.17021.64YesNo066
66B:B:E260 B:B:F253 42.52162.33YesYes266
67B:B:F222 B:B:F253 29.247510.72YesYes286
68B:B:D258 B:B:F222 24.092910.75YesYes278
69B:B:D258 B:B:R22 11.335511.91YesNo076
70B:B:I18 B:B:R22 10.77396.26YesNo076
71B:B:D258 G:G:R27 12.45725.96YesNo078
72B:B:C25 G:G:R27 10.77394.18NoNo038
73B:B:C25 B:B:Q259 10.21173.05NoNo036
74G:G:F61 G:G:N59 14.59933.62YesNo089
75B:B:N340 G:G:N59 18.083214.98NoNo099
76B:B:M45 B:B:N340 18.22864.21YesNo049
77B:B:M45 G:G:L50 18.86162.83YesNo049
78G:G:D48 G:G:L50 19.29082.71YesNo099
79B:B:S281 G:G:D48 18.12737.36NoYes099
80B:B:C271 B:B:I269 14.37864.91YesYes054
81B:B:I269 B:B:Y289 13.46447.25YesYes947
82B:B:I273 B:B:Y289 33.61388.46NoYes967
83B:B:C250 B:B:I273 33.11266.55NoNo986
84B:B:C250 B:B:Y264 33.11642.69NoYes085
85B:B:S84 B:B:W63 14.78573.71NoYes057
86B:B:D118 B:B:I120 14.99322.8NoNo096
87B:B:D118 B:B:S97 15.25478.83NoNo098
88B:B:S97 B:B:W99 15.67594.94NoYes089
89B:B:T159 B:B:W169 11.986310.92YesYes098
90B:B:I157 B:B:W169 15.98063.52NoYes078
91B:B:F151 B:B:I157 15.29178.79YesNo097
92B:B:F151 B:B:Y111 10.4712.06YesYes094
93B:B:G162 B:B:Y145 26.62532.9NoYes098
94B:B:G162 B:B:S161 26.33033.71NoYes099
95B:B:H142 B:B:T159 12.23222.74YesYes099
96B:B:D205 B:B:H183 19.72152.52YesYes899
97B:B:H183 B:B:W211 14.56094.23YesYes898
98B:B:M188 B:B:N230 16.29992.8NoNo089
99B:B:D290 B:B:G272 16.17433.35NoNo064
100B:B:D246 B:B:G272 15.9733.35NoNo094
101B:B:G282 B:B:S281 19.24653.71NoNo099
102B:B:F235 B:B:G282 10.40466.02YesNo2269
103B:B:F235 B:B:F278 14.91867.5YesYes2267
104B:B:F278 B:B:P236 11.32172.89YesYes2277
105B:B:F278 B:B:L252 14.14143.65YesNo077
106B:B:F278 B:B:L285 14.020910.96YesNo076
107B:B:N295 B:B:Y289 21.76558.14YesYes967
108R:R:D340 R:R:N342 10.12128.08YesYes486
109R:R:F289 R:R:W293 38.61228.02YesYes1098
110R:R:F241 R:R:W293 37.57328.02NoYes088
111R:R:F241 R:R:H297 36.072518.1NoNo088
112R:R:F237 R:R:H297 29.477616.97YesNo658
113R:R:F237 R:R:I234 28.99517.54YesYes054
114R:R:I234 R:R:N230 27.73512.83YesNo043
115R:R:N230 R:R:W226 26.74183.39NoYes4032
116R:R:F221 R:R:W226 26.12773.01YesYes052
117R:R:F221 R:R:K209 25.52962.48YesYes053
118R:R:K209 R:R:T207 11.93344.5YesNo3835
119R:R:N137 R:R:T207 11.6132.92NoNo015
120R:R:K209 R:R:T218 12.95896.01YesNo033
121R:R:D216 R:R:T218 12.62582.89NoNo043
122R:R:D216 R:R:N127 11.96714.04NoYes046
123B:B:H142 B:B:S161 22.762416.74YesYes1799
124A:A:F215 B:B:W99 12.21168.02YesYes1499
125B:B:D246 B:B:N230 16.09875.39NoNo099
126B:B:N295 B:B:V307 21.83414.43YesNo963
127B:B:L252 B:B:Y264 14.42133.52NoYes075
128B:B:L285 B:B:Y264 14.16084.69NoYes065
129B:B:M61 B:B:W63 16.04275.82YesYes367
130B:B:S84 G:G:F61 14.60363.96NoYes058
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9ODK
Class A
SubFamily Peptide
Type Opioid
SubType MOP
Species Mus Musculus
Ligand -
Other Ligand(s) GTP; Mg
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.9
Date 2026-01-07
D.O.I. 10.1038/s41586-025-10056-4
Net Summary
Imin 2.06
Number of Linked Nodes 940
Number of Links 1149
Number of Hubs 196
Number of Links mediated by Hubs 713
Number of Communities 41
Number of Nodes involved in Communities 302
Number of Links involved in Communities 423
Path Summary
Number Of Nodes in MetaPath 131
Number Of Links MetaPath 130
Number of Shortest Paths 874626
Length Of Smallest Path 3
Average Path Length 27.1909
Length of Longest Path 65
Minimum Path Strength 1.2
Average Path Strength 5.41875
Maximum Path Strength 29.925
Minimum Path Correlation 0.7
Average Path Correlation 0.984173
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 56.3994
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.9249
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • neuropeptide binding   • peptide binding   • protein binding   • G-protein alpha-subunit binding   • peptide receptor activity   • molecular transducer activity   • beta-endorphin receptor activity   • G protein-coupled opioid receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled peptide receptor activity   • melanocortin receptor activity   • neuropeptide receptor activity   • morphine receptor activity   • protein domain specific binding   • calcium channel activity   • monoatomic cation transmembrane transporter activity   • voltage-gated calcium channel activity   • gated channel activity   • monoatomic ion channel activity   • voltage-gated channel activity   • voltage-gated monoatomic ion channel activity   • voltage-gated monoatomic cation channel activity   • monoatomic cation channel activity   • passive transmembrane transporter activity   • calcium ion transmembrane transporter activity   • channel activity   • monoatomic ion transmembrane transporter activity   • transporter activity   • metal ion transmembrane transporter activity   • transmembrane transporter activity   • G-protein beta-subunit binding   • trans-synaptic signaling   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • modulation of chemical synaptic transmission   • signaling   • biological regulation   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling
Gene OntologyBiological Process• trans-synaptic signaling   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • modulation of chemical synaptic transmission   • signaling   • biological regulation   • cell-cell signaling   • presynaptic modulation of chemical synaptic transmission   • chemical synaptic transmission   • cell communication   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • cellular process   • cellular response to stimulus   • response to stimulus   • G protein-coupled opioid receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • multi-multicellular organism process   • multicellular organismal process   • sperm ejaculation   • reproductive process   • multicellular organismal reproductive process   • mating behavior   • behavior   • reproductive behavior   • insemination   • multi-organism reproductive process   • copulation   • system process   • nervous system process   • transmission of nerve impulse   • phospholipase C-activating G protein-coupled receptor signaling pathway   • regulation of biological quality   • negative regulation of cytosolic calcium ion concentration   • negative regulation of signaling   • negative regulation of biological process   • regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • negative regulation of response to stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of response to stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • positive regulation of nervous system development   • regulation of developmental process   • cellular developmental process   • positive regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of neurogenesis   • regulation of cell development   • regulation of nervous system development   • positive regulation of developmental process   • multicellular organism development   • neurogenesis   • positive regulation of cell differentiation   • cell differentiation   • anatomical structure development   • positive regulation of neurogenesis   • regulation of multicellular organismal process   • positive regulation of cellular process   • system development   • developmental process   • regulation of multicellular organismal development   • positive regulation of cell development   • nervous system development   • positive regulation of multicellular organismal process   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • neuropeptide signaling pathway   • monosaccharide metabolic process   • gluconeogenesis   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • small molecule metabolic process   • regulation of carbohydrate metabolic process   • regulation of glucose metabolic process   • positive regulation of gluconeogenesis   • regulation of biosynthetic process   • carbohydrate metabolic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • hexose metabolic process   • primary metabolic process   • monosaccharide biosynthetic process   • hexose biosynthetic process   • positive regulation of glucose metabolic process   • biosynthetic process   • regulation of gluconeogenesis   • metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • glucose metabolic process   • locomotory behavior   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway   • positive regulation of cell communication   • positive regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • regulation of localization   • transport   • regulation of signaling receptor activity   • regulation of transmembrane transporter activity   • localization   • regulation of NMDA receptor activity   • regulation of transport   • establishment of localization   • transmembrane transport   • regulation of molecular function   • regulation of transmembrane transport   • regulation of neurotransmitter receptor activity   • negative regulation of luteinizing hormone secretion   • regulation of system process   • negative regulation of transport   • negative regulation of secretion   • regulation of luteinizing hormone secretion   • luteinizing hormone secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • regulation of hormone levels   • regulation of secretion   • endocrine hormone secretion   • negative regulation of gonadotropin secretion   • negative regulation of multicellular organismal process   • regulation of endocrine process   • regulation of hormone secretion   • gonadotropin secretion   • hormone secretion   • secretion by cell   • regulation of secretion by cell   • signal release   • secretion   • regulation of gonadotropin secretion   • export from cell   • endocrine process   • hormone transport   • eating behavior   • feeding behavior   • regulation of cellular response to stress   • cellular response to stress   • regulation of response to stress   • response to stress   • adenylate cyclase-inhibiting opioid receptor signaling pathway   • regulation of nitric oxide biosynthetic process   • negative regulation of metabolic process   • reactive nitrogen species metabolic process   • nitric oxide metabolic process   • nitric oxide biosynthetic process   • negative regulation of nitric oxide biosynthetic process   • negative regulation of biosynthetic process   • regulation of nitric oxide metabolic process   • response to nutrient levels   • regulation of response to nutrient levels   • positive regulation of appetite   • regulation of response to food   • response to food   • positive regulation of response to food   • regulation of appetite   • positive regulation of response to nutrient levels   • adult behavior   • response to alcohol   • behavioral response to ethanol   • response to ethanol   • regulation of postsynaptic membrane potential   • chemical synaptic transmission, postsynaptic   • cell surface receptor signaling pathway   • excitatory postsynaptic potential   • regulation of membrane potential   • biological process involved in intraspecies interaction between organisms   • social behavior   • sensory perception   • sensory perception of pain   • negative regulation of protein transport   • establishment of protein localization   • regulation of protein localization   • negative regulation of Wnt protein secretion   • protein localization to extracellular region   • intracellular protein localization   • regulation of Wnt protein secretion   • negative regulation of protein localization   • establishment of protein localization to extracellular region   • regulation of establishment of protein localization   • negative regulation of establishment of protein localization   • regulation of protein transport   • Wnt protein secretion   • protein secretion   • regulation of protein secretion   • negative regulation of protein secretion   • protein transport   • macromolecule localization   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • sarcolemma   • T-tubule   • somatodendritic compartment   • cell body
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • sarcolemma   • T-tubule   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • presynapse   • presynaptic membrane   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • membrane-bounded organelle   • intracellular anatomical structure   • intracellular membrane-bounded organelle   • endomembrane system   • sarcoplasm   • intracellular organelle   • organelle   • endoplasmic reticulum   • sarcoplasmic reticulum   • cytoplasm   • axon   • mitochondrion   • anchoring junction   • focal adhesion   • cell-substrate junction   • GABA-ergic synapse   • neuron projection cytoplasm   • dendrite cytoplasm   • cell leading edge   • leading edge membrane   • neuron projection membrane   • dendrite membrane   • cell projection membrane   • endosome   • intracellular vesicle   • cytoplasmic vesicle   • vesicle   • neuron spine   • dendritic spine   • spine apparatus   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • ciliary basal body
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • Galpha insert domain-like
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases   • Galpha insert domain-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeMG
PDB ResiduesI:I:?1
Environment DetailsOpen EMBL-EBI Page
CodeMG
NameMAGNESIUM ION
Synonyms
Identifier
FormulaMg
Molecular Weight24.305
SMILES
PubChem
Formal Charge2
Total Atoms1
Total Chiral Atoms0
Total Bonds0
Total Aromatic Bonds0

CodeGTP
PDB ResiduesO:O:?1
Environment DetailsOpen EMBL-EBI Page
CodeGTP
NameGuanosine-5'-Triphosphate
SynonymsGuanosine-5'-Triphosphate
Identifier
FormulaC10 H16 N5 O14 P3
Molecular Weight523.18
SMILES
PubChem5280317
Formal Charge0
Total Atoms48
Total Chiral Atoms4
Total Bonds50
Total Aromatic Bonds5

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>9ODK_Chain_A
SAEDKAAVE RSKMIDRNL REDGEKAAR EVKLLLLGA GESGKSTIV 
KQMKIIHEA GYSEEECKQ YKAVVYSNT IQSIIAIIR AMGRLKIDF 
GDSARADDA RQLFVLAGA AEEGFMTAE LAGVIKRLW KDSGVQACF 
NRSREYQLN DSAAYYLND LDRIAQPNY IPTQQDVLR TRVKTTGIV 
ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI IFCVALSDY 
DLVLAEDEE MNRMHESMK LFDSICNNK WFTDTSIIL FLNKKDLFE 
EKIKKSPLT ICYPEYAGS NTYEEAAAY IQCQFEDLN KRKDTKEIY 
THFTCATDT KNVQFVFDA VTDVIIKNN LK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9ODK_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9ODK_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP42866
Sequence
>9ODK_Chain_R
SIVCVVGLF GNFLVMYVI VRYTKMKTA TNIYIFNLA LADALATST 
LPFQSVNYL MGTWPFGNI LCKIVISID YYNMFTSIF TLCTMSVDR 
YIAVCHPVK ALDFRTPRN AKIVNVCNW ILSSAIGLP VMFMATTKY 
RQGSIDCTL TFSTWYWEN LLKICVFIF AFIMPVLII TVCYGLMIL 
RLKRNLRRI TRMVLVVVA VFIVCWTPI HIYVIIKAL ITIPETTFQ 
TVSWHFCIA LGYTNSCLN PVLYAFLDE NFKRCFREF CI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4DKLAPeptideOpioidμMus musculusβ-Funaltrexamine--2.82012-03-21doi.org/10.1038/nature10954
5C1MAPeptideOpioidμMus musculusBU72--2.072015-08-05doi.org/10.1038/nature14886
6DDEAPeptideOpioidμMus musculusDAMGO-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDE (No Gprot) APeptideOpioidμMus musculusDAMGO-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDFAPeptideOpioidμMus musculusDAMGO-Gi1/β1/γ23.52018-06-13doi.org/10.1038/s41586-018-0219-7
6DDF (No Gprot) APeptideOpioidμMus musculusDAMGO-3.52018-06-13doi.org/10.1038/s41586-018-0219-7
7SBFAPeptideOpioidμMus musculusPZM21-Gi1/β1/γ22.92022-04-20doi.org/10.1002/anie.202200269
7SBF (No Gprot) APeptideOpioidμMus musculusPZM21-2.92022-04-20doi.org/10.1002/anie.202200269
7SCGAPeptideOpioidμMus musculusFH210-Gi1/β1/γ232022-04-20doi.org/10.1002/anie.202200269
7SCG (No Gprot) APeptideOpioidμMus musculusFH210-32022-04-20doi.org/10.1002/anie.202200269
7U2LAPeptideOpioidμMus musculusC5-guano-Gi1/β1/γ23.22022-05-04doi.org/10.1038/s41586-022-05588-y
7U2L (No Gprot) APeptideOpioidμMus musculusC5-guano-3.22022-05-04doi.org/10.1038/s41586-022-05588-y
7UL4APeptideOpioidμMus musculusAlvimopan--2.82022-06-29doi.org/10.1038/s41594-022-00859-8
8EF5APeptideOpioidμHomo sapiensFentanyl-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF5 (No Gprot) APeptideOpioidμHomo sapiensFentanyl-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6APeptideOpioidμHomo sapiensMorphine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EF6 (No Gprot) APeptideOpioidμHomo sapiensMorphine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFBAPeptideOpioidμHomo sapiensOliceridine-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFB (No Gprot) APeptideOpioidμHomo sapiensOliceridine-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFLAPeptideOpioidμHomo sapiensSR17018-Gi1/β1/γ23.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFL (No Gprot) APeptideOpioidμHomo sapiensSR17018-3.22022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFOAPeptideOpioidμHomo sapiensPZM21-Gi1/β1/γ22.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFO (No Gprot) APeptideOpioidμHomo sapiensPZM21-2.82022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQAPeptideOpioidμHomo sapiensDAMGO-Gi1/β1/γ23.32022-11-09doi.org/10.1016/j.cell.2022.09.041
8EFQ (No Gprot) APeptideOpioidμHomo sapiensDAMGO-3.32022-11-09doi.org/10.1016/j.cell.2022.09.041
7T2GAPeptideOpioidμMus musculusMitragynine Pseudoindoxyl-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2G (No Gprot) APeptideOpioidμMus musculusMitragynine Pseudoindoxyl-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2HAPeptideOpioidμMus musculusLofentanil-Gi1/β1/γ22.52022-12-07doi.org/10.1038/s41589-022-01208-y
7T2H (No Gprot) APeptideOpioidμMus musculusLofentanil-2.52022-12-07doi.org/10.1038/s41589-022-01208-y
7U2KAPeptideOpioidμMus musculusC6-guano-Gi1/β1/γ23.32022-12-07doi.org/10.1038/s41586-022-05588-y
7U2K (No Gprot) APeptideOpioidμMus musculusC6-guano-3.32022-12-07doi.org/10.1038/s41586-022-05588-y
8F7QAPeptideOpioidμHomo sapiensβ-Endorphin-Gi1/β1/γ23.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7Q (No Gprot) APeptideOpioidμHomo sapiensβ-Endorphin-3.222022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7RAPeptideOpioidμHomo sapiensEndomorphin-Gi1/β1/γ23.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8F7R (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-3.282022-12-14doi.org/10.1016/j.cell.2022.12.026
8K9KAPeptideOpioidμHomo sapiensDAMGO-Gi3/β1/γ12.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9K (No Gprot) APeptideOpioidμHomo sapiensDAMGO-2.982024-05-29doi.org/10.1038/s41467-024-47792-6
8K9LAPeptideOpioidμHomo sapiensDAMGOBMS-986122Gi3/β1/γ13.052024-05-29doi.org/10.1038/s41467-024-47792-6
8K9L (No Gprot) APeptideOpioidμHomo sapiensDAMGOBMS-9861223.052024-05-29doi.org/10.1038/s41467-024-47792-6
9BJKAPeptideOpioidμMus musculusNaloxonePubChem 171642066-3.262024-07-17doi.org/10.1038/s41586-024-07587-7
9BQJAPeptideOpioidμMus musculusRO76-Gi1/β1/γ23.32024-09-11doi.org/10.1021/acscentsci.4c00525
9BQJ (No Gprot) APeptideOpioidμMus musculusRO76-3.32024-09-11doi.org/10.1021/acscentsci.4c00525
9MQHAPeptideOpioidμHomo sapiens---3.92025-02-12doi.org/10.1101/2025.01.09.632033
9MQIAPeptideOpioidμHomo sapiensIsoquinuclidine--3.32025-02-12doi.org/10.1101/2025.01.09.632033
9MQJAPeptideOpioidμHomo sapiensIsoquinuclidine--3.232025-02-12doi.org/10.1101/2025.01.09.632033
9WSTAPeptideOpioidμHomo sapiensDAMGO-chim(NtGi1-Gz)/β1/γ22.82025-11-2610.1038/s41422-025-01191-8
9WST (No Gprot) APeptideOpioidμHomo sapiensDAMGO-2.82025-11-2610.1038/s41422-025-01191-8
9WSVAPeptideOpioidμHomo sapiensDAMGO-Arrestin22.82025-11-2610.1038/s41422-025-01191-8
9WSV (No Gprot) APeptideOpioidμHomo sapiensDAMGO-2.82025-11-2610.1038/s41422-025-01191-8
9WSWAPeptideOpioidμHomo sapiensEndomorphin-chim(NtGi1-Gz)/β1/γ22.82025-11-2610.1038/s41422-025-01191-8
9WSW (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-2.82025-11-2610.1038/s41422-025-01191-8
9WSXAPeptideOpioidμHomo sapiensEndomorphin-Arrestin22.82025-11-2610.1038/s41422-025-01191-8
9WSX (No Gprot) APeptideOpioidμHomo sapiensEndomorphin-2.82025-11-2610.1038/s41422-025-01191-8
8E0GAPeptideOpioidμMus musculusBU72--2.12023-10-18doi.org/10.1186/s12915-023-01689-w
8QOTAPeptideOpioidμMus musculusNanobody-E--3.22023-12-27doi.org/10.1101/2023.12.06.570395
8Y72APeptideOpioidμHomo sapiensPeptideBMS-986122Gi1/β1/γ22.652025-08-06To be published
8Y72 (No Gprot) APeptideOpioidμHomo sapiensPeptideBMS-9861222.652025-08-06To be published
8Y73APeptideOpioidμHomo sapiensPeptideMPAM-15Gi1/β1/γ22.842025-08-06To be published
8Y73 (No Gprot) APeptideOpioidμHomo sapiensPeptideMPAM-152.842025-08-06To be published
9PXUAPeptideOpioidμHomo sapiensNaloxoneNa-3.42025-11-1210.1038/s41586-025-09677-6
9PXVAPeptideOpioidμHomo sapiensNaloxone-Gi1/β1/γ23.022025-11-1210.1038/s41586-025-09677-6
9PXV (No Gprot) APeptideOpioidμHomo sapiensNaloxone-3.022025-11-1210.1038/s41586-025-09677-6
9PXWAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ23.82025-11-1210.1038/s41586-025-09677-6
9PXW (No Gprot) APeptideOpioidμHomo sapiensNaloxoneGDPβS3.82025-11-1210.1038/s41586-025-09677-6
9PXXAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ23.12025-11-1210.1038/s41586-025-09677-6
9PXX (No Gprot) APeptideOpioidμHomo sapiensNaloxoneGDPβS3.12025-11-1210.1038/s41586-025-09677-6
9PXYAPeptideOpioidμHomo sapiensNaloxoneGDPβSGi1/β1/γ232025-11-1210.1038/s41586-025-09677-6
9PXY (No Gprot) APeptideOpioidμHomo sapiensNaloxoneGDPβS32025-11-1210.1038/s41586-025-09677-6
9PY2APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ23.162025-11-1210.1038/s41586-025-09677-6
9PY2 (No Gprot) APeptideOpioidμHomo sapiensLoperamideGDPβS3.162025-11-1210.1038/s41586-025-09677-6
9PY3APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ23.22025-11-12To be published
9PY3 (No Gprot) APeptideOpioidμHomo sapiensLoperamideGDPβS3.22025-11-12To be published
9PY4APeptideOpioidμHomo sapiensLoperamideGDPβSGi1/β1/γ22.782025-11-1210.1038/s41586-025-09677-6
9PY4 (No Gprot) APeptideOpioidμHomo sapiensLoperamideGDPβS2.782025-11-1210.1038/s41586-025-09677-6
9ODJAPeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; MgGi1/β1/γ232026-01-0710.1038/s41586-025-10056-4
9ODJ (No Gprot) APeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; Mg32026-01-0710.1038/s41586-025-10056-4
9ODK (No Gprot) APeptideOpioidμMus musculus-GTP; Mg3.92026-01-0710.1038/s41586-025-10056-4
9ODLAPeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; MgGi1/β1/γ23.62026-01-0710.1038/s41586-025-10056-4
9ODL (No Gprot) APeptideOpioidμMus musculusMitragynine PseudoindoxylGTP; Mg3.62026-01-0710.1038/s41586-025-10056-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9ODK.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.