Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F23 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/Beta1/Gamma2 | 3.58 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/GTP/GTP_7F23_W_W_1.png)
A 2D representation of the interactions of GTP in 7F23 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:T55 | 3.64 | 6 | No | No | 9 | 9 | 1 | 1 | A:A:G52 | W:W:?1 | 7.26 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 4.55 | 0 | Yes | No | 9 | 7 | 1 | 2 | A:A:K53 | W:W:?1 | 8.23 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | W:W:?1 | 12.74 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | W:W:?1 | 10.95 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:D249 | A:A:D252 | 17.3 | 6 | Yes | Yes | 8 | 8 | 2 | 2 | A:A:D249 | A:A:K293 | 4.15 | 6 | Yes | Yes | 8 | 9 | 2 | 1 | A:A:D252 | A:A:S251 | 4.42 | 6 | Yes | No | 8 | 9 | 2 | 2 | A:A:K293 | A:A:S251 | 4.59 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 6 | Yes | No | 6 | 9 | 1 | 2 | A:A:D252 | A:A:K293 | 4.15 | 6 | Yes | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:N292 | 4.2 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 7.05 | 6 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | W:W:?1 | 16.46 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 8.14 | 6 | No | Yes | 9 | 6 | 1 | 1 | A:A:D295 | W:W:?1 | 9.36 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 3.98 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:L296 | W:W:?1 | 7.34 | 6 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | W:W:?1 | 5.85 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 2.83 | 0 | No | No | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 9.77 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 21.00 |
| ![](/psngpcr/ligands/GTP/GTP_7F23_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_7F23_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7F24 | A | Amine | Dopamine | D1 | Homo sapiens | Dopamine | GDP | Gs/Beta1/Gamma2 | 4.16 | 2022-06-15 | 10.1126/sciadv.abo4158 |
![](/psngpcr/ligands/GTP/GTP_7F24_W_W_1.png)
A 2D representation of the interactions of GTP in 7F24 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 8.46 | 0 | No | No | 9 | 8 | 1 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:D249 | A:A:N50 | 2.69 | 6 | Yes | No | 8 | 9 | 2 | 2 | A:A:K293 | A:A:N50 | 2.8 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:G52 | A:A:T55 | 5.46 | 6 | No | No | 9 | 9 | 1 | 1 | A:A:G52 | W:W:?1 | 8.17 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | W:W:?1 | 9.73 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | W:W:?1 | 11.95 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | W:W:?1 | 8.6 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:D249 | A:A:S251 | 2.94 | 6 | Yes | No | 8 | 9 | 2 | 2 | A:A:D249 | A:A:K293 | 8.3 | 6 | Yes | Yes | 8 | 9 | 2 | 1 | A:A:L296 | A:A:S251 | 4.5 | 6 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 5.64 | 6 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | W:W:?1 | 21.69 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 9.5 | 6 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 6.22 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | W:W:?1 | 9.36 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | W:W:?1 | 5.87 | 6 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | W:W:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D49 | W:W:?1 | 2.16 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:G206 | A:A:S54 | 1.86 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:I56 | A:A:T55 | 1.52 | 0 | No | No | 7 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 9.08 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 17.00 |
| ![](/psngpcr/ligands/GTP/GTP_7F24_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_7F24_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7VUI | A | Orphan | A orphans | GPR139 | Homo sapiens | JNJ-63533054 | GTP | chim(Gs-CtGq)/Beta1/Gamma2 | 3.3 | 2021-12-29 | 10.1038/s41422-021-00591-w |
![](/psngpcr/ligands/GTP/GTP_7VUI_M_M_1.png)
A 2D representation of the interactions of GTP in 7VUI colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G52 | A:A:T55 | 3.64 | 4 | No | No | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 5.44 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:S54 | 5.89 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 7.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 4 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 20.33 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 4.25 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 4.43 | 4 | Yes | No | 9 | 7 | 1 | 2 | A:A:D249 | A:A:K293 | 5.53 | 4 | No | No | 8 | 9 | 2 | 1 | A:A:L296 | A:A:S251 | 4.5 | 4 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 4 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 7.28 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 14.21 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 4.07 | 4 | No | No | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 7.2 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 3.67 | 4 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:D49 | M:M:?1 | 2.88 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 8.04 | Average Nodes In Shell | 15.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 12.00 |
| ![](/psngpcr/ligands/GTP/GTP_7VUI_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_7VUI_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GFV | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.1 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GFV_M_M_1.png)
A 2D representation of the interactions of GTP in 8GFV colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 8.46 | 6 | No | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 2.71 | 6 | No | Yes | 9 | 8 | 2 | 2 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 0 | No | No | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 7.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 12.44 | 6 | No | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 2.99 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 3.06 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 10.36 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 7.82 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 2.96 | 6 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 4.59 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 6 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 6.99 | 6 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 7.28 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 11.97 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 6 | No | No | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 7.92 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 6 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.85 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 1.56 | 0 | No | No | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 7.15 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GFV_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GFV_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GFW | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GFW_M_M_1.png)
A 2D representation of the interactions of GTP in 8GFW colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 9 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 9 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:S51 | A:A:V247 | 4.85 | 0 | No | No | 9 | 7 | 1 | 2 | A:A:S51 | M:M:?1 | 3.19 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 7.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 8.3 | 9 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 5.98 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 3.06 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 8.76 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 7.82 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 5.66 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 9 | Yes | No | 9 | 7 | 1 | 2 | A:A:K293 | A:A:S251 | 6.12 | 9 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 9 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 2.8 | 9 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 5.85 | 9 | Yes | No | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 4.37 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 7.05 | 9 | Yes | No | 9 | 6 | 1 | 2 | A:A:K293 | M:M:?1 | 16.46 | 9 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 3.11 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 5.76 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.65 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GFW_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GFW_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GFX | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GFX_M_M_1.png)
A 2D representation of the interactions of GTP in 8GFX colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 8 | No | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 2.71 | 8 | No | Yes | 9 | 8 | 2 | 2 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 9.68 | 8 | No | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 6.73 | 8 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 4.59 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 7.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 5.67 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 7.82 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 8.5 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 8 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:K293 | A:A:N292 | 5.6 | 8 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 2.92 | 8 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 2.91 | 8 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 14.96 | 8 | No | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 4.07 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 4.67 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 7.2 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.02 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:E50 | M:M:?1 | 1.41 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 6.23 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 22.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GFX_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GFX_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GFY | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GFY_M_M_1.png)
A 2D representation of the interactions of GTP in 8GFY colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 5 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 4.07 | 5 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | M:M:?1 | 5.62 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 8.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 6.91 | 5 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 2.99 | 5 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 5.58 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 4.25 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 7.82 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 5 | No | No | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 4.25 | 5 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 5 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 5 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 5 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 4.2 | 5 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 2.92 | 5 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 5.83 | 5 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 4.23 | 5 | Yes | No | 9 | 6 | 1 | 2 | A:A:K293 | M:M:?1 | 16.46 | 5 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 6.22 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 6.48 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.02 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:E50 | A:A:R265 | 2.33 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:E50 | A:A:G49 | 1.64 | 0 | No | No | 9 | 8 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 7.11 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GFY_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GFY_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GFZ | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GFZ_M_M_1.png)
A 2D representation of the interactions of GTP in 8GFZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 4.23 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 1 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:R265 | 4.65 | 0 | No | Yes | 9 | 9 | 1 | 2 | A:A:E50 | M:M:?1 | 2.81 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:S51 | 3.06 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 1 | No | No | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 8.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 8.3 | 1 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 4.55 | 1 | Yes | No | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 5.24 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 11.15 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:T55 | 9.01 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 4.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 5.66 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 1 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | A:A:K300 | A:A:S251 | 4.59 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 4.2 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 2.92 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 2.91 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 2.82 | 1 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 15.71 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 7.78 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 5.76 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K300 | A:A:L296 | 2.82 | 1 | Yes | Yes | 9 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 2.94 | 1 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:G49 | M:M:?1 | 0.91 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 5.86 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GFZ_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GFZ_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG0 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 2.9 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG0_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG0 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 4 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 4.07 | 4 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:R265 | 6.98 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:E50 | M:M:?1 | 4.92 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:S51 | 4.59 | 4 | Yes | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 6.46 | 4 | No | No | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 5.44 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 9.68 | 4 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 4.55 | 4 | Yes | No | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 4.49 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 4.59 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 9.56 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 5.67 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 5.47 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 5.66 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 4 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 4 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 4 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 2.92 | 4 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 2.91 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 14.96 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 6.22 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 6.48 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G49 | M:M:?1 | 0.91 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.93 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 27.00 | Average Links Mediated by Hubs In Shell | 22.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG0_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG0_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG1 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG1_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG1 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 7 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 7 | No | Yes | 9 | 8 | 2 | 2 | A:A:G52 | M:M:?1 | 7.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 9.68 | 7 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 4.55 | 7 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 3.74 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 3.06 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 7.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 5.67 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 4.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 7 | No | Yes | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 7.08 | 7 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 7 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 7 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 0 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 2.8 | 7 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 7 | Yes | No | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 4.37 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 15.71 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 4.67 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 6.48 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.70 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 24.00 | Average Links Mediated by Hubs In Shell | 19.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG1_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG1_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG2 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG2_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 4.23 | 11 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 11 | No | Yes | 9 | 8 | 2 | 2 | A:A:E50 | A:A:K293 | 9.45 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 7.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 9.68 | 11 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 4.55 | 11 | Yes | No | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 3.74 | 11 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 3.19 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 5.67 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 3.91 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 7.08 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 11 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 11 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 0 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 2.8 | 11 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 11 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 4.37 | 11 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 13.47 | 11 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 4.67 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 6.48 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G49 | M:M:?1 | 0.91 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.28 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 24.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG2_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG2_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG3 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.1 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG3_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:E50 | A:A:K293 | 8.1 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 8.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 4.78 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 7.09 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 6.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 3 | No | Yes | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 7.08 | 3 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 4.43 | 3 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 4.59 | 3 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 3 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 2.92 | 3 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 2.91 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 14.21 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 3 | No | No | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 4.32 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 3 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G49 | M:M:?1 | 0.91 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.32 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 21.00 | Average Links Mediated by Hubs In Shell | 17.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG3_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG3_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG4 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.2 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG4_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG4 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 4.23 | 8 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 8 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 8.3 | 8 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 3.74 | 8 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 7.82 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 8 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | M:M:?1 | 8.98 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 8 | No | No | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 7.92 | 8 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 3.67 | 8 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.80 | Average Nodes In Shell | 15.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 17.00 | Average Links Mediated by Hubs In Shell | 15.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG4_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG4_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG5 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.2 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG5_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG5 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 13 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 13 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 3.06 | 13 | Yes | No | 9 | 9 | 1 | 2 | A:A:G52 | M:M:?1 | 5.44 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 8.3 | 13 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 4.49 | 13 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 7.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 4.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 6.42 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 13 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 5.6 | 0 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:K293 | M:M:?1 | 7.48 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 13 | No | No | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 7.2 | 13 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 3.67 | 13 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.44 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 20.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG5_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG5_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG6 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG6_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG6 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:G52 | M:M:?1 | 5.44 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 3.06 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 4.78 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 3.91 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 8.03 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 2 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 2.82 | 2 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 8.98 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 2 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 5.76 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 5.14 | 2 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.46 | Average Nodes In Shell | 14.00 | Average Hubs In Shell | 3.00 | Average Links In Shell | 16.00 | Average Links Mediated by Hubs In Shell | 13.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG6_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG6_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG7 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG7_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG7 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:E50 | A:A:R265 | 5.82 | 0 | No | Yes | 9 | 9 | 1 | 2 | A:A:E50 | M:M:?1 | 2.81 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:S51 | 3.06 | 3 | Yes | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 3 | No | Yes | 9 | 7 | 2 | 2 | A:A:G52 | A:A:T55 | 3.64 | 3 | No | No | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 4.54 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 3.04 | 3 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 4.49 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 7.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 4.69 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 3 | No | Yes | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 2.83 | 3 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 3 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 9.18 | 3 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 3 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 6.99 | 3 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 2.91 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 6.73 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 3 | No | Yes | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 5.04 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 3.67 | 3 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:G49 | M:M:?1 | 1.81 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:G47 | A:A:K53 | 1.74 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:Q59 | A:A:T55 | 1.42 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 4.37 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 29.00 | Average Links Mediated by Hubs In Shell | 26.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG7_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG7_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG8 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG8_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG8 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:S51 | 1.86 | 2 | No | No | 9 | 9 | 2 | 2 | A:A:G47 | A:A:K53 | 1.74 | 2 | No | Yes | 9 | 9 | 2 | 1 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:E50 | A:A:K293 | 5.4 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:S51 | 4.59 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:V247 | 3.04 | 2 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 6.73 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:T55 | 3 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:A366 | A:A:T55 | 3.36 | 2 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 10.17 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 2 | No | Yes | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 2.83 | 2 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 4.43 | 2 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 2 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 5.6 | 2 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:A366 | A:A:N292 | 4.69 | 2 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 2.91 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 7.48 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 2 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 2 | Yes | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 4.32 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 2 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:C365 | A:A:V367 | 1.71 | 2 | Yes | No | 8 | 9 | 1 | 1 | A:A:C365 | A:A:D368 | 4.67 | 2 | Yes | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 3.37 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:D368 | A:A:V367 | 4.38 | 2 | No | No | 9 | 9 | 2 | 1 | A:A:V367 | M:M:?1 | 4.74 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 4.97 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 7.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG8_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG8_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GG9 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GG9_M_M_1.png)
A 2D representation of the interactions of GTP in 8GG9 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:R201 | 13.96 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:E50 | A:A:R258 | 12.79 | 1 | No | Yes | 9 | 4 | 1 | 2 | A:A:E50 | M:M:?1 | 3.51 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | A:A:S51 | 3.71 | 1 | No | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 3.06 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:G52 | A:A:T55 | 3.64 | 1 | No | No | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 5.44 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 12.44 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 9.73 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 5.58 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 1 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 8.6 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 1 | Yes | No | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 2.83 | 1 | Yes | Yes | 7 | 9 | 2 | 1 | A:A:A366 | A:A:I56 | 3.25 | 1 | No | Yes | 9 | 7 | 2 | 2 | A:A:D173 | A:A:K293 | 5.53 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:D173 | M:M:?1 | 6.48 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:R199 | A:A:V367 | 9.15 | 10 | No | No | 7 | 9 | 2 | 1 | A:A:L203 | A:A:R201 | 6.07 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:R201 | A:A:R258 | 4.26 | 1 | Yes | Yes | 9 | 4 | 1 | 2 | A:A:R201 | M:M:?1 | 4.51 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 4.43 | 1 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 7.65 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 1 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:A366 | A:A:N292 | 4.69 | 1 | No | Yes | 9 | 9 | 2 | 1 | A:A:N292 | M:M:?1 | 2.91 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 2.82 | 1 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 5.24 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 10.89 | 1 | Yes | No | 8 | 9 | 1 | 2 | A:A:L296 | M:M:?1 | 4.41 | 1 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:C365 | A:A:D368 | 4.67 | 1 | Yes | No | 8 | 9 | 1 | 2 | A:A:C365 | A:A:T369 | 3.38 | 1 | Yes | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 3.37 | 1 | Yes | Yes | 8 | 0 | 1 | 0 | A:A:D368 | A:A:V367 | 5.84 | 1 | No | No | 9 | 9 | 2 | 1 | A:A:V367 | M:M:?1 | 7.9 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D368 | A:A:T369 | 2.89 | 1 | No | No | 9 | 9 | 2 | 2 | A:A:G49 | A:A:K53 | 1.74 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:S54 | A:A:T204 | 1.6 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 5.64 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 43.00 | Average Links Mediated by Hubs In Shell | 36.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GG9_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GG9_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GGA | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GGA_M_M_1.png)
A 2D representation of the interactions of GTP in 8GGA colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 4.07 | 1 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 5.23 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:I172 | 2.73 | 1 | No | No | 9 | 7 | 1 | 2 | A:A:D173 | A:A:E50 | 5.2 | 1 | No | No | 9 | 9 | 1 | 1 | A:A:E50 | M:M:?1 | 3.51 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 7.65 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 1 | No | Yes | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 5.44 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 2.77 | 1 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 3.04 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 10.47 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 5.58 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 1 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 7.82 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 1 | No | Yes | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 2.83 | 1 | No | Yes | 7 | 9 | 2 | 1 | A:A:D173 | A:A:K293 | 5.53 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:D173 | M:M:?1 | 2.88 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:F178 | 2.79 | 0 | No | Yes | 9 | 7 | 1 | 2 | A:A:C174 | M:M:?1 | 2.53 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:F178 | A:A:Y177 | 5.16 | 0 | Yes | No | 7 | 9 | 2 | 2 | A:A:R199 | A:A:Y177 | 3.09 | 1 | No | No | 7 | 9 | 1 | 2 | A:A:L198 | A:A:V367 | 2.98 | 1 | Yes | No | 9 | 9 | 2 | 1 | A:A:R199 | A:A:V367 | 2.62 | 1 | No | No | 7 | 9 | 1 | 1 | A:A:R199 | M:M:?1 | 5.16 | 1 | No | Yes | 7 | 0 | 1 | 0 | A:A:L203 | A:A:R201 | 17.01 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:R201 | M:M:?1 | 4.51 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 4.43 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K293 | A:A:S251 | 6.12 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 7.51 | 0 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 5.6 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:A366 | A:A:N292 | 4.69 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 2.91 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 2.99 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 9.34 | 1 | Yes | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 5.76 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 0 | No | Yes | 6 | 0 | 1 | 0 | A:A:C365 | A:A:T369 | 3.38 | 1 | Yes | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 2.53 | 1 | Yes | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:V367 | M:M:?1 | 5.53 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:G49 | M:M:?1 | 1.81 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:C365 | A:A:D368 | 1.56 | 1 | Yes | No | 8 | 9 | 1 | 2 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | No | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 17.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 4.50 | Average Nodes In Shell | 34.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 47.00 | Average Links Mediated by Hubs In Shell | 37.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GGA_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GGA_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GGB | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GGB_M_M_1.png)
A 2D representation of the interactions of GTP in 8GGB colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:S51 | 1.86 | 1 | No | Yes | 9 | 9 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 1 | No | Yes | 9 | 9 | 2 | 1 | A:A:D173 | A:A:E50 | 2.6 | 1 | No | Yes | 9 | 9 | 1 | 2 | A:A:E50 | A:A:R201 | 3.49 | 0 | Yes | No | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | Yes | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 6.12 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 1 | Yes | Yes | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 12.44 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 3.04 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 8.98 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 1 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 6.26 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:I172 | 3.27 | 0 | No | No | 9 | 7 | 1 | 2 | A:A:D173 | A:A:K293 | 4.15 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:D173 | M:M:?1 | 2.88 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:F178 | 5.59 | 0 | No | Yes | 9 | 7 | 1 | 2 | A:A:C174 | M:M:?1 | 2.53 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:F178 | A:A:Y177 | 5.16 | 1 | Yes | No | 7 | 9 | 2 | 2 | A:A:R199 | A:A:Y177 | 12.35 | 1 | Yes | No | 7 | 9 | 1 | 2 | A:A:F178 | A:A:R199 | 2.14 | 1 | Yes | Yes | 7 | 7 | 2 | 1 | A:A:L198 | A:A:Q195 | 3.99 | 1 | Yes | No | 9 | 8 | 2 | 2 | A:A:Q195 | A:A:R199 | 2.34 | 1 | No | Yes | 8 | 7 | 2 | 1 | A:A:Q195 | A:A:V367 | 4.3 | 1 | No | Yes | 8 | 9 | 2 | 1 | A:A:L198 | A:A:V367 | 2.98 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | A:A:R199 | A:A:V367 | 2.62 | 1 | Yes | Yes | 7 | 9 | 1 | 1 | A:A:R199 | M:M:?1 | 3.22 | 1 | Yes | Yes | 7 | 0 | 1 | 0 | A:A:R201 | M:M:?1 | 5.16 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 4.43 | 1 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 4.59 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 1 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 8.39 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:A366 | A:A:N292 | 4.69 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 5.1 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 5.24 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 1 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 1 | No | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 7.92 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 3.98 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 2.94 | 1 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:C365 | M:M:?1 | 3.37 | 1 | No | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:V367 | M:M:?1 | 5.53 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D368 | 1.56 | 1 | No | No | 8 | 9 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 4.95 | Average Nodes In Shell | 30.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 46.00 | Average Links Mediated by Hubs In Shell | 42.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GGB_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GGB_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GGC | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GGC_M_M_1.png)
A 2D representation of the interactions of GTP in 8GGC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 4 | Yes | No | 9 | 8 | 1 | 2 | A:A:G52 | A:A:S51 | 3.71 | 4 | No | No | 9 | 9 | 1 | 1 | A:A:K53 | A:A:S51 | 4.59 | 4 | Yes | No | 9 | 9 | 1 | 1 | A:A:S51 | M:M:?1 | 3.19 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 6.35 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 6.91 | 4 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 11.22 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 3.19 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 4 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 4.69 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:D173 | A:A:K293 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:R199 | A:A:V367 | 6.54 | 11 | Yes | No | 7 | 9 | 2 | 1 | A:A:L203 | A:A:R201 | 4.86 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:R201 | M:M:?1 | 7.73 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 4.43 | 4 | Yes | No | 9 | 7 | 1 | 2 | A:A:K293 | A:A:S251 | 6.12 | 4 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 0 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 2.8 | 4 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:A366 | A:A:N292 | 4.69 | 4 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 6.56 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 10.47 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 4 | No | No | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 4.67 | 4 | No | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 7.2 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D368 | 6.22 | 4 | No | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 3.37 | 4 | No | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:D368 | A:A:V367 | 2.92 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:V367 | M:M:?1 | 7.9 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T204 | M:M:?1 | 0.78 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.91 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 30.00 | Average Links Mediated by Hubs In Shell | 22.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GGC_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GGC_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GGE | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GGE_M_M_1.png)
A 2D representation of the interactions of GTP in 8GGE colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 0 | No | No | 9 | 8 | 1 | 2 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 9.68 | 0 | Yes | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 6.73 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:S54 | 4.42 | 0 | Yes | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 5.58 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 3 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 6.26 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:N98 | 4.72 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:D173 | A:A:L296 | 5.43 | 0 | No | Yes | 9 | 6 | 1 | 2 | A:A:D173 | M:M:?1 | 7.92 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:R199 | 2.79 | 0 | No | Yes | 9 | 7 | 1 | 2 | A:A:C174 | M:M:?1 | 2.53 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:R199 | A:A:V367 | 3.92 | 25 | Yes | No | 7 | 9 | 2 | 1 | A:A:L203 | A:A:R201 | 8.5 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:R201 | M:M:?1 | 7.73 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:S251 | 7.65 | 3 | No | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 3 | Yes | No | 6 | 9 | 2 | 2 | A:A:N292 | A:A:T364 | 4.39 | 3 | No | No | 9 | 9 | 1 | 2 | A:A:A366 | A:A:N292 | 4.69 | 3 | No | No | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 3.64 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 5.64 | 3 | No | Yes | 9 | 6 | 1 | 2 | A:A:K293 | M:M:?1 | 5.98 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 4.07 | 3 | No | Yes | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 3.11 | 3 | No | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 5.04 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D368 | 3.11 | 3 | No | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 2.53 | 3 | No | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:V367 | M:M:?1 | 11.85 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | A:A:S51 | 1.86 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:Q195 | A:A:V367 | 1.43 | 0 | No | No | 8 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 13.00 | Average Number Of Links With An Hub | 0.00 | Average Interaction Strength | 5.67 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 21.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GGE_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GGE_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8GGF | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8GGF_M_M_1.png)
A 2D representation of the interactions of GTP in 8GGF colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:E50 | A:A:R201 | 8.14 | 0 | Yes | No | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 2.77 | 1 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V224 | 3.04 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:K53 | M:M:?1 | 11.22 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:S54 | 4.42 | 1 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 5.47 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:D173 | 3.11 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:D173 | A:A:K293 | 5.53 | 1 | No | Yes | 9 | 9 | 1 | 1 | A:A:D173 | M:M:?1 | 13.68 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q195 | A:A:Y177 | 2.25 | 1 | No | Yes | 8 | 9 | 2 | 2 | A:A:R199 | A:A:Y177 | 24.69 | 1 | No | Yes | 7 | 9 | 1 | 2 | A:A:Q195 | A:A:R199 | 2.34 | 1 | No | No | 8 | 7 | 2 | 1 | A:A:Q195 | A:A:V367 | 2.87 | 1 | No | No | 8 | 9 | 2 | 1 | A:A:R199 | M:M:?1 | 3.87 | 1 | No | Yes | 7 | 0 | 1 | 0 | A:A:R201 | M:M:?1 | 7.09 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:V224 | 2.92 | 1 | No | Yes | 9 | 9 | 2 | 2 | A:A:K293 | A:A:S251 | 3.06 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 2.82 | 1 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 5.98 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 1 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 6.22 | 1 | No | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 4.32 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.2 | 1 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:C365 | M:M:?1 | 2.53 | 1 | No | Yes | 8 | 0 | 1 | 0 | A:A:V367 | M:M:?1 | 5.53 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G47 | A:A:K53 | 1.74 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:A366 | A:A:T55 | 1.68 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:A249 | A:A:K293 | 1.61 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:L203 | A:A:R201 | 1.21 | 0 | No | No | 7 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 12.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.22 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 8.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/GTP/GTP_8GGF_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8GGF_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNL | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNL_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNL colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 7.05 | 0 | Yes | No | 9 | 8 | 1 | 2 | A:A:G49 | M:M:?1 | 3.63 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 0 | No | No | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 7.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 12.44 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 5.24 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 7.97 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:T55 | 3 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:Q59 | A:A:T55 | 2.83 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 8.6 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 4.43 | 6 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 6 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 6 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 6 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 7.28 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 4.23 | 6 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 12.72 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 6 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 7.78 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 5.04 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 6 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.02 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G47 | A:A:K53 | 1.74 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:G49 | 1.64 | 0 | No | No | 9 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 6.57 | Average Nodes In Shell | 23.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 27.00 | Average Links Mediated by Hubs In Shell | 21.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNL_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNL_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNM | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNM_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNM colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 0 | No | Yes | 9 | 8 | 1 | 2 | A:A:E50 | A:A:G49 | 3.27 | 0 | No | No | 9 | 8 | 1 | 2 | A:A:E50 | A:A:R265 | 8.14 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:E50 | M:M:?1 | 3.51 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 13.83 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 6.73 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 4.59 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 8.76 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 11 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 3 | 11 | Yes | Yes | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 11 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 5.64 | 11 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 11.97 | 11 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 4.67 | 11 | Yes | No | 8 | 9 | 1 | 2 | A:A:L296 | M:M:?1 | 2.2 | 11 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | A:A:C365 | 1.81 | 11 | No | Yes | 9 | 8 | 1 | 1 | A:A:C365 | A:A:V367 | 1.71 | 11 | Yes | No | 8 | 9 | 1 | 2 | A:A:C365 | A:A:D368 | 4.67 | 11 | Yes | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 3.37 | 11 | Yes | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 11 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.66 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 19.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNM_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNM_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNN | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNN_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNN colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 4.07 | 2 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:K293 | 4.05 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 2 | No | Yes | 9 | 9 | 1 | 1 | A:A:K53 | A:A:S51 | 3.06 | 2 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:S51 | A:A:V247 | 4.85 | 2 | Yes | No | 9 | 7 | 1 | 2 | A:A:S51 | M:M:?1 | 3.19 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 5.44 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 2.77 | 2 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:R228 | 2.48 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:V247 | 3.04 | 2 | Yes | No | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 6.73 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 3.06 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 11.15 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 7.09 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 3.13 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 2.96 | 2 | No | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 4.59 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 2 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 2 | Yes | No | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 5.1 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 13.47 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 2 | No | Yes | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 6.48 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 3.98 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 4.41 | 2 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.02 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:G49 | M:M:?1 | 1.81 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:I56 | A:A:T55 | 1.52 | 0 | No | No | 7 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 5.99 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNN_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNN_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNO | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNO_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNO colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 11 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 5.43 | 11 | No | Yes | 9 | 8 | 2 | 2 | A:A:G49 | M:M:?1 | 3.63 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:E50 | A:A:K293 | 8.1 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 5.44 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 15.21 | 11 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 2.99 | 11 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 4.78 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:T55 | 3.04 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 3.91 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 11 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 0 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 5.6 | 11 | Yes | No | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 2.91 | 11 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 8.98 | 11 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:D295 | M:M:?1 | 10.08 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 6.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:G52 | A:A:S51 | 1.86 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:G47 | A:A:K53 | 1.74 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.49 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 22.00 | Average Links Mediated by Hubs In Shell | 17.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNO_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNO_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNP | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNP_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNP colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 0 | No | No | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 3.19 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 5.67 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 10.95 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 7.08 | 7 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 7 | Yes | No | 9 | 7 | 1 | 2 | A:A:K293 | A:A:S251 | 3.06 | 7 | No | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 0 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:N292 | 6.99 | 7 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 7 | Yes | No | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 5.1 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 19.45 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:D295 | M:M:?1 | 5.04 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.02 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:V367 | 1.7 | 0 | No | No | 9 | 9 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 7.87 | Average Nodes In Shell | 16.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 18.00 | Average Links Mediated by Hubs In Shell | 11.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNP_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNP_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNQ | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNQ_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNQ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 6 | No | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 2.71 | 6 | No | Yes | 9 | 8 | 2 | 2 | A:A:G52 | A:A:S51 | 3.71 | 6 | No | No | 9 | 9 | 1 | 1 | A:A:S51 | A:A:V247 | 4.85 | 6 | No | No | 9 | 7 | 1 | 2 | A:A:S51 | M:M:?1 | 3.19 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | A:A:N292 | 3.39 | 6 | No | Yes | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 5.44 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 15.21 | 6 | No | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 3.74 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 4.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 5.66 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 6 | Yes | No | 9 | 7 | 1 | 2 | A:A:K293 | A:A:S251 | 6.12 | 6 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 6 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 6 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 8.01 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 2.82 | 6 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 11.97 | 6 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 6 | No | Yes | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 5.04 | 6 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 2.65 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 2.94 | 6 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:G49 | M:M:?1 | 1.81 | 0 | No | Yes | 8 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.14 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 22.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNQ_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNQ_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNR | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNR_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNR colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 7.05 | 3 | No | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 12.21 | 3 | No | Yes | 9 | 8 | 2 | 2 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 16.59 | 3 | No | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 2.99 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 11.15 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 5.67 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 3.91 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 2.96 | 3 | No | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 3 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 3 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 3 | Yes | No | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 5.83 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 18.7 | 3 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 3 | No | No | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 7.2 | 3 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 3 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | A:A:S51 | 1.86 | 0 | No | No | 9 | 9 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 7.03 | Average Nodes In Shell | 17.00 | Average Hubs In Shell | 3.00 | Average Links In Shell | 20.00 | Average Links Mediated by Hubs In Shell | 14.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNR_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNR_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNS | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNS_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNS colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:K53 | 3.49 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:A48 | A:A:G49 | 1.95 | 5 | No | No | 8 | 8 | 2 | 1 | A:A:A48 | A:A:R265 | 4.15 | 5 | No | Yes | 8 | 9 | 2 | 2 | A:A:G49 | A:A:R265 | 3 | 5 | No | Yes | 8 | 9 | 1 | 2 | A:A:G49 | M:M:?1 | 2.72 | 5 | No | Yes | 8 | 0 | 1 | 0 | A:A:E50 | A:A:K293 | 5.4 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 1.86 | 5 | No | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 3.06 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:G52 | A:A:T55 | 1.82 | 5 | No | No | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 6.35 | 5 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | M:M:?1 | 5.98 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 7.97 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 10.17 | 5 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 5 | No | No | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 4.25 | 5 | No | No | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 5 | No | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 5 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 5 | Yes | No | 6 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 3.64 | 5 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 2.82 | 5 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 7.48 | 5 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 5 | No | Yes | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 5.76 | 5 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 3.67 | 5 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 1.56 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 5.71 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 28.00 | Average Links Mediated by Hubs In Shell | 19.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNS_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNS_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNT | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNT_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 4.23 | 1 | No | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 6.79 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | A:A:G49 | M:M:?1 | 3.63 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:E50 | A:A:K293 | 4.05 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 2.77 | 1 | Yes | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 2.99 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | A:A:T55 | 3.2 | 1 | No | No | 9 | 9 | 1 | 1 | A:A:K58 | A:A:S54 | 3.06 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 11.15 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 10.17 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 2.96 | 1 | No | No | 9 | 7 | 1 | 2 | A:A:K293 | A:A:S251 | 4.59 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 1 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 2.8 | 1 | Yes | No | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 3.64 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 4.23 | 1 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 19.45 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 1 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 1 | No | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 4.32 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 1 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:C365 | M:M:?1 | 3.37 | 1 | No | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:E299 | A:A:L296 | 1.33 | 0 | No | Yes | 6 | 6 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 6.40 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 21.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNT_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNT_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNU | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNU_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNU colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 4.23 | 0 | Yes | No | 9 | 8 | 1 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 3.06 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 0 | No | No | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | M:M:?1 | 5.24 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 4.59 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 9.56 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 15 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 6.26 | 15 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 5.66 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 0 | No | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 20 | No | No | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 4.59 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 15 | No | No | 6 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 5.1 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 8.98 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 15 | No | No | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 4.67 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 7.2 | 15 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 15 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 15 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 6.20 | Average Nodes In Shell | 19.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 23.00 | Average Links Mediated by Hubs In Shell | 12.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNU_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNU_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNV | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.3 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNV_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNV colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 4.23 | 2 | Yes | No | 9 | 8 | 1 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:A249 | A:A:E50 | 4.53 | 2 | No | Yes | 8 | 9 | 2 | 2 | A:A:E50 | A:A:K293 | 6.75 | 2 | Yes | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 2 | No | Yes | 9 | 9 | 1 | 1 | A:A:K53 | A:A:S51 | 9.18 | 2 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:S51 | A:A:V247 | 4.85 | 2 | Yes | No | 9 | 7 | 1 | 2 | A:A:S51 | M:M:?1 | 3.19 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 6.35 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:V247 | 4.55 | 2 | Yes | No | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 7.48 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 10.36 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 2 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 3.91 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 4.82 | 2 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 4.59 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 2 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 11.19 | 2 | Yes | No | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 4.39 | 2 | No | No | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 8.74 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 2.82 | 2 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 17.95 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 5.43 | 2 | No | Yes | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 6.48 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 3.67 | 2 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:V367 | 1.71 | 0 | No | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 1.68 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:K58 | A:A:T55 | 1.5 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:D223 | A:A:K53 | 1.38 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 6.73 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 30.00 | Average Links Mediated by Hubs In Shell | 26.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNV_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNV_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNW | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNW_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNW colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:K53 | 6.97 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:K293 | 4.05 | 3 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 6.12 | 10 | Yes | No | 9 | 9 | 1 | 2 | A:A:S51 | A:A:V247 | 4.85 | 10 | No | Yes | 9 | 7 | 2 | 2 | A:A:G52 | M:M:?1 | 5.44 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 8.3 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:V247 | 3.04 | 10 | Yes | Yes | 9 | 7 | 1 | 2 | A:A:K53 | M:M:?1 | 2.99 | 10 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 6.26 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 7.65 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 0 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | M:M:?1 | 5.98 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 0 | No | No | 9 | 6 | 1 | 2 | A:A:D295 | M:M:?1 | 4.32 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 2.51 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 4.57 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 4.00 | Average Links In Shell | 20.00 | Average Links Mediated by Hubs In Shell | 16.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNW_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNW_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNX | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNX_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNX colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 2.82 | 1 | Yes | No | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 4.07 | 1 | No | No | 9 | 8 | 2 | 2 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:E50 | M:M:?1 | 7.03 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 5.53 | 1 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 5.98 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:T55 | 3.04 | 1 | Yes | No | 7 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 4.69 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 7.08 | 1 | Yes | Yes | 7 | 9 | 2 | 1 | A:A:I56 | A:A:T364 | 3.04 | 1 | Yes | Yes | 7 | 9 | 2 | 2 | A:A:N292 | A:A:V247 | 2.96 | 1 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 7.51 | 1 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 5.6 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:N292 | A:A:T364 | 2.92 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:N292 | M:M:?1 | 2.91 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 10.47 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 1 | No | No | 9 | 6 | 1 | 1 | A:A:D295 | M:M:?1 | 10.8 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 1 | No | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 5.85 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:G47 | A:A:K53 | 1.74 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:A366 | A:A:V367 | 1.7 | 0 | No | No | 9 | 9 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 5.85 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 26.00 | Average Links Mediated by Hubs In Shell | 22.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNX_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNX_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNY | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNY_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNY colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:S51 | 1.86 | 2 | No | Yes | 9 | 9 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 2 | No | No | 9 | 9 | 2 | 1 | A:A:E50 | A:A:G49 | 1.64 | 2 | Yes | No | 9 | 8 | 1 | 2 | A:A:E50 | A:A:R265 | 4.65 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:E50 | A:A:K293 | 5.4 | 2 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:E50 | M:M:?1 | 2.11 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:G52 | A:A:S51 | 3.71 | 2 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 3.06 | 2 | No | Yes | 9 | 9 | 1 | 2 | A:A:G52 | A:A:T55 | 3.64 | 2 | Yes | No | 9 | 9 | 1 | 1 | A:A:G52 | A:A:N292 | 1.7 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:G52 | M:M:?1 | 3.63 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K53 | M:M:?1 | 7.48 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:S54 | 4.59 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 7.97 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:T55 | 4.56 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 14.08 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:N292 | 4.25 | 0 | No | No | 7 | 9 | 2 | 2 | A:A:A249 | A:A:K293 | 1.61 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 2 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 2 | Yes | Yes | 6 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 9.87 | 2 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 15.71 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:Q294 | 3.05 | 2 | Yes | No | 8 | 6 | 1 | 2 | A:A:D295 | A:A:L296 | 6.79 | 2 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 2 | Yes | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 6.48 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.2 | 2 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | A:A:C365 | 1.81 | 2 | No | Yes | 9 | 8 | 1 | 1 | A:A:C365 | A:A:D368 | 1.56 | 2 | Yes | Yes | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 3.37 | 2 | Yes | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 2 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.72 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 9.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 27.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNY_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNY_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UNZ | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.8 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UNZ_M_M_1.png)
A 2D representation of the interactions of GTP in 8UNZ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 0 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:E50 | A:A:K293 | 4.05 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | A:A:S51 | 3.06 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:G52 | M:M:?1 | 4.54 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | M:M:?1 | 10.47 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 15.13 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T55 | M:M:?1 | 15.64 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 7.65 | 14 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 5.6 | 14 | Yes | No | 9 | 9 | 1 | 2 | A:A:K293 | A:A:L296 | 2.82 | 14 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 11.97 | 14 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 14 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 7.78 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 7.92 | 14 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 3.98 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 3.67 | 14 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 3.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 9.09 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 19.00 | Average Links Mediated by Hubs In Shell | 18.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UNZ_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UNZ_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO0 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UO0_M_M_1.png)
A 2D representation of the interactions of GTP in 8UO0 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:K53 | A:A:L45 | 5.64 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | A:A:D223 | A:A:L45 | 2.71 | 2 | No | Yes | 9 | 8 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:G49 | M:M:?1 | 3.63 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 5.53 | 2 | No | Yes | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 6.73 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 7.97 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A249 | A:A:S252 | 3.42 | 2 | No | No | 8 | 8 | 2 | 2 | A:A:A249 | A:A:K293 | 6.42 | 2 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 2 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 2 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:S252 | 4.59 | 2 | Yes | No | 9 | 8 | 1 | 2 | A:A:K293 | A:A:L296 | 2.82 | 2 | Yes | Yes | 9 | 6 | 1 | 1 | A:A:K293 | M:M:?1 | 17.95 | 2 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 8.14 | 2 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 3.11 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 6.48 | 2 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 2.65 | 0 | No | Yes | 6 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 6.61 | 2 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:E50 | A:A:G49 | 1.64 | 0 | No | No | 9 | 8 | 2 | 1 | A:A:T55 | M:M:?1 | 1.56 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:T55 | 1.5 | 0 | No | No | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 6.83 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 24.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UO0_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UO0_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO1 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UO1_M_M_1.png)
A 2D representation of the interactions of GTP in 8UO1 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:K53 | 3.49 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:D173 | A:A:E50 | 3.9 | 7 | No | No | 9 | 9 | 1 | 1 | A:A:E50 | M:M:?1 | 4.22 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:G52 | M:M:?1 | 6.35 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | M:M:?1 | 4.49 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 6.37 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:A366 | A:A:T55 | 3.36 | 7 | No | No | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 4.69 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:D173 | A:A:K293 | 6.91 | 7 | No | Yes | 9 | 9 | 1 | 1 | A:A:D173 | M:M:?1 | 7.2 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:C174 | A:A:R199 | 4.18 | 0 | No | Yes | 9 | 7 | 2 | 1 | A:A:R199 | A:A:Y177 | 9.26 | 7 | Yes | No | 7 | 9 | 1 | 2 | A:A:Q195 | A:A:V367 | 4.3 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:R199 | A:A:V367 | 2.62 | 7 | Yes | Yes | 7 | 9 | 1 | 1 | A:A:R199 | M:M:?1 | 5.8 | 7 | Yes | Yes | 7 | 0 | 1 | 0 | A:A:R201 | M:M:?1 | 9.67 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:L203 | I:I:?402 | 2.66 | 0 | No | No | 7 | 0 | 2 | 1 | A:A:N292 | A:A:V247 | 2.96 | 7 | Yes | No | 9 | 7 | 1 | 2 | A:A:K293 | A:A:N292 | 4.2 | 7 | Yes | Yes | 9 | 9 | 1 | 1 | A:A:A366 | A:A:N292 | 4.69 | 7 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 7.28 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | A:A:L296 | 2.82 | 7 | Yes | No | 9 | 6 | 1 | 2 | A:A:K293 | M:M:?1 | 16.46 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:C365 | A:A:D295 | 9.34 | 0 | No | No | 8 | 9 | 1 | 2 | A:A:C365 | A:A:T369 | 5.07 | 0 | No | No | 8 | 9 | 1 | 2 | A:A:C365 | M:M:?1 | 3.37 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:D368 | A:A:V367 | 8.76 | 0 | No | Yes | 9 | 9 | 2 | 1 | A:A:V367 | M:M:?1 | 4.74 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | I:I:?402 | M:M:?1 | 2.82 | 0 | No | Yes | 0 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 15.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 6.02 | Average Nodes In Shell | 27.00 | Average Hubs In Shell | 5.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UO1_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UO1_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO2 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP | Gs/Beta1/Gamma2 | 3.6 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UO2_M_M_1.png)
A 2D representation of the interactions of GTP in 8UO2 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:K53 | 3.49 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:G49 | M:M:?1 | 2.72 | 0 | No | Yes | 8 | 0 | 1 | 0 | A:A:E50 | A:A:R201 | 13.96 | 4 | No | Yes | 9 | 9 | 1 | 1 | A:A:E50 | M:M:?1 | 4.22 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:S51 | 3.06 | 0 | No | No | 9 | 9 | 1 | 2 | A:A:G52 | A:A:T55 | 3.64 | 4 | No | Yes | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 5.44 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | M:M:?1 | 8.23 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | M:M:?1 | 9.56 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:K58 | A:A:T55 | 4.5 | 4 | No | Yes | 9 | 9 | 2 | 1 | A:A:L198 | A:A:T55 | 2.95 | 4 | No | Yes | 9 | 9 | 2 | 1 | A:A:A366 | A:A:T55 | 3.36 | 4 | No | Yes | 9 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 9.38 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:V247 | 3.07 | 4 | No | No | 7 | 7 | 2 | 2 | A:A:I56 | A:A:N292 | 2.83 | 4 | No | Yes | 7 | 9 | 2 | 1 | A:A:K58 | A:A:L198 | 9.87 | 4 | No | No | 9 | 9 | 2 | 2 | A:A:I172 | A:A:R201 | 2.51 | 0 | No | Yes | 7 | 9 | 2 | 1 | A:A:D173 | A:A:R199 | 13.1 | 4 | No | No | 9 | 7 | 1 | 1 | A:A:D173 | A:A:L296 | 2.71 | 4 | No | Yes | 9 | 6 | 1 | 1 | A:A:D173 | M:M:?1 | 5.76 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:R199 | M:M:?1 | 12.89 | 4 | No | Yes | 7 | 0 | 1 | 0 | A:A:R201 | M:M:?1 | 7.09 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:N292 | A:A:V247 | 2.96 | 4 | Yes | No | 9 | 7 | 1 | 2 | A:A:A249 | A:A:K293 | 4.82 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 3.06 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 4 | Yes | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:R265 | 3.71 | 0 | Yes | No | 9 | 9 | 1 | 2 | A:A:N292 | A:A:T364 | 2.92 | 4 | Yes | No | 9 | 9 | 1 | 2 | A:A:A366 | A:A:N292 | 4.69 | 4 | No | Yes | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 3.64 | 4 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 4.49 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 4 | No | Yes | 9 | 6 | 1 | 1 | A:A:C365 | A:A:D295 | 6.22 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:D295 | M:M:?1 | 5.04 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:L296 | M:M:?1 | 2.94 | 4 | Yes | Yes | 6 | 0 | 1 | 0 | A:A:A366 | M:M:?1 | 4.18 | 4 | No | Yes | 9 | 0 | 1 | 0 | A:A:A48 | A:A:G49 | 1.95 | 0 | No | No | 8 | 8 | 2 | 1 | A:A:N98 | A:A:R201 | 1.21 | 0 | No | Yes | 9 | 9 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 14.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.11 | Average Nodes In Shell | 29.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 38.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UO2_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UO2_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO3 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 3.5 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UO3_M_M_1.png)
A 2D representation of the interactions of GTP in 8UO3 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:E50 | A:A:R201 | 4.65 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:G52 | M:M:?1 | 8.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:K53 | 4.15 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:K53 | M:M:?1 | 11.22 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:S54 | 2.94 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 3.19 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:S54 | I:I:?402 | 5.77 | 1 | No | No | 9 | 0 | 1 | 1 | A:A:A366 | A:A:T55 | 3.36 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:T55 | M:M:?1 | 5.47 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:D173 | M:M:?1 | 15.84 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q195 | A:A:R199 | 5.84 | 1 | No | No | 8 | 7 | 2 | 2 | A:A:Q195 | A:A:V367 | 4.3 | 1 | No | No | 8 | 9 | 2 | 1 | A:A:R199 | A:A:V367 | 7.85 | 1 | No | No | 7 | 9 | 2 | 1 | A:A:L203 | A:A:R201 | 4.86 | 0 | No | No | 7 | 9 | 2 | 1 | A:A:R201 | M:M:?1 | 5.8 | 0 | No | Yes | 9 | 0 | 1 | 0 | A:A:T204 | I:I:?402 | 8.49 | 0 | No | No | 9 | 0 | 2 | 1 | A:A:A249 | A:A:K293 | 3.21 | 0 | No | Yes | 8 | 9 | 2 | 1 | A:A:K293 | A:A:S251 | 6.12 | 1 | Yes | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 6.01 | 1 | No | No | 6 | 9 | 2 | 2 | A:A:K293 | A:A:L296 | 4.23 | 1 | Yes | No | 9 | 6 | 1 | 2 | A:A:K293 | M:M:?1 | 6.73 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D295 | A:A:L296 | 6.79 | 1 | No | No | 9 | 6 | 1 | 2 | A:A:C365 | A:A:D295 | 4.67 | 1 | No | No | 8 | 9 | 1 | 1 | A:A:D295 | M:M:?1 | 4.32 | 1 | No | Yes | 9 | 0 | 1 | 0 | A:A:C365 | M:M:?1 | 3.37 | 1 | No | Yes | 8 | 0 | 1 | 0 | A:A:V367 | M:M:?1 | 7.9 | 1 | No | Yes | 9 | 0 | 1 | 0 | I:I:?402 | M:M:?1 | 5.64 | 1 | No | Yes | 0 | 0 | 1 | 0 | A:A:G49 | A:A:K53 | 1.74 | 0 | No | No | 8 | 9 | 2 | 1 | A:A:C365 | A:A:N371 | 1.57 | 1 | No | No | 8 | 9 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 1.00 | Average Interaction Strength | 7.06 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 2.00 | Average Links In Shell | 29.00 | Average Links Mediated by Hubs In Shell | 14.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UO3_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UO3_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8UO4 | A | Amine | Adrenergic | Beta2 | Homo sapiens | Epinephrine | GTP; Mg | Gs/Beta1/Gamma2 | 4 | 2024-03-06 | 10.1038/s41586-024-07153-1 |
![](/psngpcr/ligands/GTP/GTP_8UO4_M_M_1.png)
A 2D representation of the interactions of GTP in 8UO4 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | A:A:G47 | A:A:S51 | 1.86 | 7 | No | Yes | 9 | 9 | 2 | 2 | A:A:G47 | A:A:K53 | 3.49 | 7 | No | Yes | 9 | 9 | 2 | 1 | A:A:G52 | A:A:S51 | 3.71 | 7 | No | Yes | 9 | 9 | 1 | 2 | A:A:K53 | A:A:S51 | 6.12 | 7 | Yes | Yes | 9 | 9 | 1 | 2 | A:A:G52 | A:A:T55 | 1.82 | 7 | No | Yes | 9 | 9 | 1 | 1 | A:A:G52 | M:M:?1 | 7.26 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:K53 | A:A:S54 | 3.06 | 7 | Yes | No | 9 | 9 | 1 | 1 | A:A:K53 | M:M:?1 | 13.47 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:D223 | A:A:S54 | 5.89 | 0 | No | No | 9 | 9 | 2 | 1 | A:A:S54 | M:M:?1 | 5.58 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:Q59 | A:A:T55 | 4.25 | 0 | Yes | Yes | 9 | 9 | 2 | 1 | A:A:C200 | A:A:T55 | 3.38 | 7 | No | Yes | 7 | 9 | 1 | 1 | A:A:T55 | M:M:?1 | 9.38 | 7 | Yes | Yes | 9 | 0 | 1 | 0 | A:A:I56 | A:A:Q59 | 2.74 | 0 | Yes | Yes | 7 | 9 | 2 | 2 | A:A:I56 | A:A:N292 | 2.83 | 0 | Yes | No | 7 | 9 | 2 | 1 | A:A:R199 | M:M:?1 | 2.58 | 0 | No | Yes | 7 | 0 | 1 | 0 | A:A:C200 | M:M:?1 | 4.21 | 7 | No | Yes | 7 | 0 | 1 | 0 | A:A:V202 | M:M:?1 | 11.85 | 0 | No | Yes | 6 | 0 | 1 | 0 | A:A:K293 | A:A:S251 | 4.59 | 7 | No | No | 9 | 9 | 1 | 2 | A:A:L296 | A:A:S251 | 4.5 | 0 | No | No | 6 | 9 | 1 | 2 | A:A:K293 | A:A:N292 | 6.99 | 7 | No | No | 9 | 9 | 1 | 1 | A:A:N292 | M:M:?1 | 5.83 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:K293 | M:M:?1 | 10.47 | 7 | No | Yes | 9 | 0 | 1 | 0 | A:A:E299 | A:A:L296 | 2.65 | 0 | No | No | 6 | 6 | 2 | 1 | A:A:L296 | M:M:?1 | 2.94 | 0 | No | Yes | 6 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 2.00 | Average Interaction Strength | 7.36 | Average Nodes In Shell | 18.00 | Average Hubs In Shell | 6.00 | Average Links In Shell | 25.00 | Average Links Mediated by Hubs In Shell | 20.00 |
| ![](/psngpcr/ligands/GTP/GTP_8UO4_M_M_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/GTP/GTP_8UO4_M_M_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|