CodeGTP
NameGuanosine-5'-Triphosphate
SynonymsGuanosine-5'-Triphosphate
Identifier
FormulaC10 H16 N5 O14 P3
Molecular Weight523.18
SMILES
PubChem6830
Formal Charge0
Total Atoms48
Total Chiral Atoms4
Total Bonds50
Total Aromatic Bonds5
Networks43
 missing image

This ligand is also present in the following 43 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F23 A Amine Dopamine D1 Homo Sapiens Dopamine GDP Gs/Beta1/Gamma2 3.58 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of GTP in 7F23
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:G52 A:A:T55 3.64 6 No No 9 9 1 1
A:A:G52 O:O:?1 7.33 6 No Yes 9 0 1 0
A:A:D223 A:A:K53 4.15 0 No Yes 9 9 2 1
A:A:K53 A:A:V247 4.55 0 Yes No 9 7 1 2
A:A:K53 O:O:?1 8.31 0 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 12.87 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 11.05 6 No Yes 9 0 1 0
A:A:D249 A:A:D252 17.3 6 Yes Yes 8 8 2 2
A:A:D249 A:A:K293 4.15 6 Yes Yes 8 9 2 1
A:A:D252 A:A:S251 4.42 6 Yes No 8 9 2 2
A:A:K293 A:A:S251 4.59 6 Yes No 9 9 1 2
A:A:L296 A:A:S251 4.5 6 Yes No 6 9 1 2
A:A:D252 A:A:K293 4.15 6 Yes Yes 8 9 2 1
A:A:K293 A:A:N292 4.2 6 Yes No 9 9 1 2
A:A:K293 A:A:L296 7.05 6 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 16.62 6 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 8.14 6 No Yes 9 6 1 1
A:A:D295 O:O:?1 9.45 6 No Yes 9 0 1 0
A:A:E299 A:A:L296 3.98 0 No Yes 6 6 2 1
A:A:L296 O:O:?1 7.41 6 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 5.91 0 No Yes 9 0 1 0
A:A:Q59 A:A:T55 2.83 0 No No 9 9 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.87
Average Nodes In Shell18.00
Average Hubs In Shell6.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F24 A Amine Dopamine D1 Homo Sapiens Dopamine GDP Gs/Beta1/Gamma2 4.16 2022-06-15 10.1126/sciadv.abo4158

A 2D representation of the interactions of GTP in 7F24
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 8.46 0 No No 9 8 1 2
A:A:G47 A:A:K53 3.49 0 No No 9 9 2 1
A:A:D249 A:A:N50 2.69 6 Yes No 8 9 2 2
A:A:K293 A:A:N50 2.8 6 Yes No 9 9 1 2
A:A:G52 A:A:T55 5.46 6 No No 9 9 1 1
A:A:G52 O:O:?1 8.25 6 No Yes 9 0 1 0
A:A:K53 O:O:?1 9.82 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 12.06 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 8.69 6 No Yes 9 0 1 0
A:A:D249 A:A:S251 2.94 6 Yes No 8 9 2 2
A:A:D249 A:A:K293 8.3 6 Yes Yes 8 9 2 1
A:A:L296 A:A:S251 4.5 6 Yes No 6 9 1 2
A:A:K293 A:A:N292 4.2 6 Yes No 9 9 1 2
A:A:K293 A:A:L296 5.64 6 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 21.9 6 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 9.5 6 No Yes 9 6 1 1
A:A:C365 A:A:D295 6.22 0 No No 8 9 2 1
A:A:D295 O:O:?1 9.45 6 No Yes 9 0 1 0
A:A:L296 O:O:?1 5.93 6 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:D49 O:O:?1 2.18 0 No Yes 8 0 1 0
A:A:G206 A:A:S54 1.86 0 No No 8 9 2 1
A:A:I56 A:A:T55 1.52 0 No No 7 9 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.17
Average Nodes In Shell19.00
Average Hubs In Shell4.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7VUI A Orphan Orphan GPR139 Homo Sapiens JNJ-63533054 GTP chim(Gs-CtGq)/Beta1/Gamma2 3.3 2021-12-29 10.1038/s41422-021-00591-w

A 2D representation of the interactions of GTP in 7VUI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G52 A:A:T55 3.64 4 No No 9 9 1 1
A:A:G52 O:O:?1 5.5 4 No Yes 9 0 1 0
A:A:D223 A:A:S54 5.89 0 No No 9 9 2 1
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 4 No No 9 9 1 1
A:A:T55 O:O:?1 20.53 4 No Yes 9 0 1 0
A:A:I56 A:A:N292 4.25 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 4.43 4 Yes No 9 7 1 2
A:A:D249 A:A:K293 5.53 4 No No 8 9 2 1
A:A:L296 A:A:S251 4.5 4 No No 6 9 1 2
A:A:K293 A:A:N292 4.2 4 No Yes 9 9 1 1
A:A:N292 O:O:?1 7.36 4 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 14.35 4 No Yes 9 0 1 0
A:A:D295 A:A:L296 4.07 4 No No 9 6 1 1
A:A:D295 O:O:?1 7.27 4 No Yes 9 0 1 0
A:A:L296 O:O:?1 3.71 4 No Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 4 No Yes 9 0 1 0
A:A:D49 O:O:?1 2.91 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.12
Average Nodes In Shell15.00
Average Hubs In Shell2.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFV A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.1 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GFV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 8.46 0 No No 9 8 1 2
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:S51 A:A:V247 4.85 0 No No 9 7 2 2
A:A:G52 O:O:?1 7.33 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 4.15 0 No No 9 9 2 1
A:A:K53 O:O:?1 3.02 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 10.46 0 No Yes 9 0 1 0
A:A:K58 A:A:T55 3 0 No No 9 9 2 1
A:A:T55 O:O:?1 7.9 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 6 Yes No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 4.59 6 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 6 Yes No 6 9 1 2
A:A:K293 A:A:N292 6.99 6 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 4.39 6 Yes No 9 9 1 2
A:A:N292 O:O:?1 7.36 6 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 12.09 6 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 6 Yes Yes 9 6 1 1
A:A:D295 A:A:E299 5.2 6 Yes No 9 6 1 2
A:A:D295 O:O:?1 8 6 Yes Yes 9 0 1 0
A:A:E299 A:A:L296 11.93 6 No Yes 6 6 2 1
A:A:L296 O:O:?1 2.97 6 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 5.91 0 No Yes 9 0 1 0
A:A:A366 A:A:V367 1.7 0 No No 9 9 1 2
A:A:C365 A:A:D295 1.56 0 No Yes 8 9 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.23
Average Nodes In Shell21.00
Average Hubs In Shell5.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFW A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GFW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 9 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 9 No Yes 9 8 2 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:S51 A:A:V247 4.85 0 No No 9 7 1 2
A:A:S51 O:O:?1 3.22 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 7.33 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 8.3 9 No Yes 9 9 2 1
A:A:K53 O:O:?1 6.04 9 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 8.85 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 7.9 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 5.66 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 9 Yes No 9 7 1 2
A:A:K293 A:A:S251 6.12 9 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 9 No No 6 9 2 2
A:A:K293 A:A:N292 2.8 9 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 5.85 9 Yes No 9 9 1 2
A:A:N292 O:O:?1 4.41 9 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 7.05 9 Yes No 9 6 1 2
A:A:K293 O:O:?1 16.62 9 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 0 No No 9 6 1 2
A:A:C365 A:A:D295 3.11 0 No No 8 9 2 1
A:A:D295 O:O:?1 5.82 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.72
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFX A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GFX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 8 No Yes 9 8 1 2
A:A:D223 A:A:L45 2.71 8 No Yes 9 8 2 2
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 9.68 8 No No 9 9 2 1
A:A:K53 O:O:?1 6.8 8 No Yes 9 0 1 0
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 7.9 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 8.5 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 8 Yes No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No No 8 9 2 1
A:A:K293 A:A:N292 5.6 8 No Yes 9 9 1 1
A:A:N292 A:A:T364 2.92 8 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 2.94 8 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 15.11 8 No Yes 9 0 1 0
A:A:D295 A:A:L296 4.07 0 No No 9 6 1 2
A:A:C365 A:A:D295 4.67 0 No No 8 9 2 1
A:A:D295 O:O:?1 7.27 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 5.06 0 No Yes 9 0 1 0
A:A:A366 A:A:V367 1.7 0 No No 9 9 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.83
Average Nodes In Shell19.00
Average Hubs In Shell4.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFY A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GFY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 4 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 4.07 4 No Yes 9 8 2 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 O:O:?1 5.68 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 8.25 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 6.91 4 No Yes 9 9 2 1
A:A:K53 O:O:?1 3.02 4 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 5.63 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 7.9 0 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 4 No No 7 7 2 2
A:A:I56 A:A:N292 4.25 4 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 4 Yes No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 4 Yes No 9 9 1 2
A:A:L296 A:A:S251 4.5 4 No No 6 9 2 2
A:A:K293 A:A:N292 4.2 4 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 2.92 4 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 5.88 4 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 4.23 4 Yes No 9 6 1 2
A:A:K293 O:O:?1 16.62 4 Yes Yes 9 0 1 0
A:A:C365 A:A:D295 6.22 0 No No 8 9 2 1
A:A:D295 O:O:?1 6.54 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 5.06 0 No Yes 9 0 1 0
A:A:E50 A:A:R265 2.33 0 No No 9 9 1 2
A:A:E50 A:A:G49 1.64 0 No No 9 8 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.18
Average Nodes In Shell22.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GFZ A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GFZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 3 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 3 No Yes 9 8 2 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 O:O:?1 4.26 0 No Yes 9 0 1 0
A:A:K53 A:A:S51 3.06 3 Yes No 9 9 1 2
A:A:S51 A:A:V247 4.85 3 No No 9 7 2 2
A:A:G52 O:O:?1 8.25 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 8.3 3 No Yes 9 9 2 1
A:A:K53 A:A:V247 4.55 3 Yes No 9 7 1 2
A:A:K53 O:O:?1 5.29 3 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 11.26 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 4.74 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 5.66 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 3 Yes No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 3 Yes Yes 9 9 1 2
A:A:L296 A:A:S251 6.01 0 No Yes 6 9 1 2
A:A:K293 A:A:N292 4.2 3 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 2.92 3 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 2.94 3 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 15.86 3 Yes Yes 9 0 1 0
A:A:C365 A:A:D295 7.78 0 No No 8 9 2 1
A:A:D295 O:O:?1 5.82 0 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 0 No Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:Q59 A:A:T55 1.42 0 No No 9 9 2 1
A:A:G49 O:O:?1 0.92 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.05
Average Nodes In Shell23.00
Average Hubs In Shell7.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell24.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG0 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 2.9 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 A:A:R265 6.98 0 No Yes 9 9 1 2
A:A:E50 O:O:?1 4.97 0 No Yes 9 0 1 0
A:A:K53 A:A:S51 4.59 13 Yes No 9 9 1 2
A:A:S51 A:A:V247 6.46 13 No No 9 7 2 2
A:A:G52 O:O:?1 5.5 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 9.68 0 No Yes 9 9 2 1
A:A:K53 A:A:V247 4.55 13 Yes No 9 7 1 2
A:A:K53 O:O:?1 4.53 13 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 9.65 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 5.53 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 0 Yes No 9 9 1 2
A:A:K293 A:A:N292 4.2 0 Yes No 9 9 1 2
A:A:K293 O:O:?1 15.11 0 Yes Yes 9 0 1 0
A:A:C365 A:A:D295 6.22 0 No No 8 9 2 1
A:A:D295 O:O:?1 6.54 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:G49 O:O:?1 0.92 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.33
Average Nodes In Shell19.00
Average Hubs In Shell4.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG1 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 8 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 8 No Yes 9 8 2 2
A:A:E50 A:A:R265 4.65 0 No Yes 9 9 1 2
A:A:E50 O:O:?1 2.84 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 7.33 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 9.68 8 No Yes 9 9 2 1
A:A:K53 A:A:V247 4.55 8 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 3.78 8 Yes Yes 9 0 1 0
A:A:K58 A:A:S54 6.12 0 No No 9 9 2 1
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 4.74 0 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 8 No Yes 7 7 2 2
A:A:I56 A:A:N292 7.08 8 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 8 Yes Yes 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 8 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 0 No No 6 9 2 2
A:A:K293 A:A:N292 2.8 8 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 4.39 8 Yes No 9 9 1 2
A:A:N292 O:O:?1 4.41 8 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 15.86 8 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 0 No No 9 6 1 2
A:A:C365 A:A:D295 4.67 0 No No 8 9 2 1
A:A:D295 O:O:?1 6.54 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.33
Average Nodes In Shell21.00
Average Hubs In Shell7.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG2 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 12 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 12 No Yes 9 8 2 2
A:A:G52 O:O:?1 7.33 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 9.68 12 No Yes 9 9 2 1
A:A:K53 A:A:V247 4.55 12 Yes No 9 7 1 2
A:A:K53 O:O:?1 3.78 12 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 3.22 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 3.95 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 7.08 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 12 Yes No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 12 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 0 No No 6 9 2 2
A:A:K293 A:A:N292 2.8 12 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 4.39 12 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 4.41 12 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 13.6 12 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 0 No No 9 6 1 2
A:A:C365 A:A:D295 4.67 0 No No 8 9 2 1
A:A:D295 O:O:?1 6.54 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.88
Average Nodes In Shell18.00
Average Hubs In Shell6.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG3 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.1 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G52 O:O:?1 8.25 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 4.83 0 No Yes 9 0 1 0
A:A:K58 A:A:T55 16.52 0 No No 9 9 2 1
A:A:T55 O:O:?1 6.32 0 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 2 No Yes 7 7 2 2
A:A:I56 A:A:N292 7.08 2 No Yes 7 9 2 1
A:A:N292 A:A:V247 4.43 2 Yes Yes 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 4.59 2 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 2 No No 6 9 1 2
A:A:K293 A:A:N292 2.8 2 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 2.92 2 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 2.94 2 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 14.35 2 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 2 Yes No 9 6 1 1
A:A:D295 A:A:E299 3.9 2 Yes No 9 6 1 2
A:A:C365 A:A:D295 3.11 0 No Yes 8 9 2 1
A:A:D295 O:O:?1 4.36 2 Yes Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 2 No Yes 6 0 1 0
A:A:A366 O:O:?1 3.38 0 No Yes 9 0 1 0
A:A:G49 O:O:?1 0.92 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.37
Average Nodes In Shell18.00
Average Hubs In Shell6.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG4 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 8 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 8 No Yes 9 8 2 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 A:A:R265 4.65 0 No Yes 9 9 1 2
A:A:E50 O:O:?1 4.26 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 8.3 8 No Yes 9 9 2 1
A:A:K53 O:O:?1 3.78 8 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 7.9 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 0 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 8 No No 6 9 1 2
A:A:K293 A:A:N292 2.8 0 Yes No 9 9 1 2
A:A:K293 O:O:?1 9.06 0 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 8 No No 9 6 1 1
A:A:D295 O:O:?1 8 8 No Yes 9 0 1 0
A:A:L296 O:O:?1 3.71 8 No Yes 6 0 1 0
A:A:A366 O:O:?1 3.38 0 No Yes 9 0 1 0
A:A:E50 A:A:G49 1.64 0 No No 9 8 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.68
Average Nodes In Shell18.00
Average Hubs In Shell5.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG5 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.2 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 4 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 5.43 4 No Yes 9 8 2 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 A:A:G49 3.27 0 No No 9 8 1 2
A:A:E50 A:A:R265 4.65 0 No No 9 9 1 2
A:A:E50 O:O:?1 2.84 0 No Yes 9 0 1 0
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:K53 A:A:S51 3.06 4 Yes No 9 9 1 2
A:A:G52 O:O:?1 5.5 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 8.3 4 No Yes 9 9 2 1
A:A:K53 O:O:?1 4.53 4 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 4.74 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 6.42 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 0 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 4 No No 6 9 1 2
A:A:K293 A:A:N292 5.6 0 Yes Yes 9 9 1 2
A:A:K293 O:O:?1 7.55 0 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 4 No No 9 6 1 1
A:A:C365 A:A:D295 3.11 0 No No 8 9 2 1
A:A:D295 O:O:?1 7.27 4 No Yes 9 0 1 0
A:A:L296 O:O:?1 3.71 4 No Yes 6 0 1 0
A:A:A366 O:O:?1 3.38 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.20
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG6 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:G52 O:O:?1 5.5 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 4.83 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 3.95 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 8.03 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 6 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 6 Yes No 6 9 1 2
A:A:K293 A:A:N292 4.2 6 Yes No 9 9 1 2
A:A:K293 A:A:L296 2.82 6 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 9.06 6 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 6 No Yes 9 6 1 1
A:A:C365 A:A:D295 3.11 0 No No 8 9 2 1
A:A:D295 O:O:?1 5.82 6 No Yes 9 0 1 0
A:A:L296 O:O:?1 5.19 6 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.51
Average Nodes In Shell13.00
Average Hubs In Shell3.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG7 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:S51 3.06 1 Yes No 9 9 1 2
A:A:S51 A:A:V247 4.85 1 No Yes 9 7 2 2
A:A:G52 A:A:T55 3.64 1 No No 9 9 1 1
A:A:G52 O:O:?1 4.58 1 No Yes 9 0 1 0
A:A:D223 A:A:K53 4.15 0 No Yes 9 9 2 1
A:A:K53 A:A:V247 3.04 1 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 4.53 1 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 4.74 1 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 1 Yes Yes 7 7 2 2
A:A:I56 A:A:N292 2.83 1 Yes Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 1 Yes Yes 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 9.18 1 Yes No 9 9 1 2
A:A:L296 A:A:S251 4.5 1 No No 6 9 1 2
A:A:K293 A:A:N292 6.99 1 Yes Yes 9 9 1 1
A:A:N292 O:O:?1 2.94 1 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 6.8 1 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 1 No No 9 6 1 1
A:A:D295 O:O:?1 5.09 1 No Yes 9 0 1 0
A:A:L296 O:O:?1 3.71 1 No Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:G49 O:O:?1 1.83 0 No Yes 8 0 1 0
A:A:G47 A:A:K53 1.74 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength4.57
Average Nodes In Shell19.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG8 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:S51 1.86 2 No No 9 9 2 2
A:A:G47 A:A:K53 1.74 2 No Yes 9 9 2 1
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:K53 A:A:S51 4.59 2 Yes No 9 9 1 2
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:K53 A:A:V247 3.04 2 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 6.8 2 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 2 No No 9 9 1 1
A:A:T55 O:O:?1 10.26 2 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 2 No Yes 7 7 2 2
A:A:I56 A:A:N292 2.83 2 No Yes 7 9 2 1
A:A:N292 A:A:V247 4.43 2 Yes Yes 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 2 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 2 No No 6 9 1 2
A:A:K293 A:A:N292 5.6 2 Yes Yes 9 9 1 1
A:A:A366 A:A:N292 4.69 2 No Yes 9 9 1 1
A:A:N292 O:O:?1 2.94 2 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 7.55 2 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 2 No No 9 6 1 1
A:A:C365 A:A:D295 3.11 2 No No 8 9 1 1
A:A:D295 O:O:?1 4.36 2 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 2 No Yes 6 0 1 0
A:A:C365 A:A:V367 1.71 2 No No 8 9 1 1
A:A:C365 O:O:?1 3.4 2 No Yes 8 0 1 0
A:A:A366 O:O:?1 3.38 2 No Yes 9 0 1 0
A:A:D368 A:A:V367 5.84 0 No No 9 9 2 1
A:A:V367 O:O:?1 4.79 2 No Yes 9 0 1 0
A:A:E50 A:A:G49 1.64 0 No No 9 8 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.02
Average Nodes In Shell22.00
Average Hubs In Shell5.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GG9 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GG9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 A:A:I172 5.47 1 No Yes 9 7 1 2
A:A:E50 A:A:R201 13.96 1 No No 9 9 1 1
A:A:E50 O:O:?1 3.55 1 No Yes 9 0 1 0
A:A:G52 A:A:S51 3.71 1 No No 9 9 1 2
A:A:K53 A:A:S51 3.06 0 Yes No 9 9 1 2
A:A:G52 A:A:T55 3.64 1 No No 9 9 1 1
A:A:G52 O:O:?1 5.5 1 No Yes 9 0 1 0
A:A:D223 A:A:K53 12.44 0 No Yes 9 9 2 1
A:A:K53 O:O:?1 9.82 0 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 5.63 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 1 No No 9 9 2 1
A:A:T55 O:O:?1 8.69 1 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 1 Yes No 7 7 2 2
A:A:I56 A:A:N292 2.83 1 Yes Yes 7 9 2 1
A:A:A366 A:A:I56 3.25 1 No Yes 9 7 2 2
A:A:I172 A:A:R201 5.01 1 Yes No 7 9 2 1
A:A:D173 A:A:K293 5.53 1 No Yes 9 9 1 1
A:A:D173 O:O:?1 6.54 1 No Yes 9 0 1 0
A:A:R199 A:A:V367 9.15 0 No No 7 9 2 1
A:A:R201 O:O:?1 4.56 1 No Yes 9 0 1 0
A:A:N292 A:A:V247 4.43 1 Yes No 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 7.65 1 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 1 Yes No 6 9 1 2
A:A:K293 A:A:N292 2.8 1 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 4.39 1 Yes No 9 9 1 2
A:A:A366 A:A:N292 4.69 1 No Yes 9 9 2 1
A:A:N292 O:O:?1 2.94 1 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 2.82 1 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 5.29 1 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 14.93 1 No Yes 9 6 1 1
A:A:C365 A:A:D295 3.11 1 Yes No 8 9 1 1
A:A:D295 O:O:?1 10.18 1 No Yes 9 0 1 0
A:A:L296 O:O:?1 4.45 1 Yes Yes 6 0 1 0
A:A:C365 A:A:D368 4.67 1 Yes No 8 9 1 2
A:A:C365 A:A:T369 3.38 1 Yes No 8 9 1 2
A:A:C365 O:O:?1 3.4 1 Yes Yes 8 0 1 0
A:A:D368 A:A:V367 5.84 1 No No 9 9 2 1
A:A:V367 O:O:?1 7.98 0 No Yes 9 0 1 0
A:A:D368 A:A:T369 2.89 1 No No 9 9 2 2
A:A:G49 A:A:K53 1.74 0 No Yes 8 9 2 1
A:A:S54 A:A:T204 1.6 0 No No 9 9 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.04
Average Nodes In Shell29.00
Average Hubs In Shell8.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGA A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GGA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 1 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 4.07 1 No Yes 9 8 2 2
A:A:G47 A:A:K53 5.23 0 No Yes 9 9 2 1
A:A:E50 A:A:I172 2.73 1 No No 9 7 1 2
A:A:D173 A:A:E50 5.2 1 No No 9 9 1 1
A:A:E50 O:O:?1 3.55 1 No Yes 9 0 1 0
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:K53 A:A:S51 7.65 1 Yes No 9 9 1 2
A:A:S51 A:A:V247 4.85 1 No Yes 9 7 2 2
A:A:G52 O:O:?1 5.5 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 2.77 1 No Yes 9 9 2 1
A:A:K53 A:A:V247 3.04 1 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 10.57 1 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 5.63 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 1 No No 9 9 1 1
A:A:T55 O:O:?1 7.9 1 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 1 No Yes 7 7 2 2
A:A:I56 A:A:N292 2.83 1 No Yes 7 9 2 1
A:A:D173 A:A:K293 5.53 1 No Yes 9 9 1 1
A:A:D173 O:O:?1 2.91 1 No Yes 9 0 1 0
A:A:C174 A:A:F178 2.79 0 No Yes 9 7 1 2
A:A:C174 O:O:?1 2.55 0 No Yes 9 0 1 0
A:A:F178 A:A:Y177 5.16 0 Yes Yes 7 9 2 2
A:A:R199 A:A:Y177 3.09 1 No Yes 7 9 1 2
A:A:L198 A:A:V367 2.98 0 No No 9 9 2 1
A:A:R199 A:A:V367 2.62 1 No No 7 9 1 1
A:A:R199 O:O:?1 5.21 1 No Yes 7 0 1 0
A:A:R201 O:O:?1 4.56 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 4.43 1 Yes Yes 9 7 1 2
A:A:K293 A:A:S251 6.12 1 Yes No 9 9 1 2
A:A:L296 A:A:S251 7.51 0 No No 6 9 1 2
A:A:K293 A:A:N292 5.6 1 Yes Yes 9 9 1 1
A:A:A366 A:A:N292 4.69 1 No Yes 9 9 1 1
A:A:N292 O:O:?1 2.94 1 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 3.02 1 Yes Yes 9 0 1 0
A:A:C365 A:A:D295 9.34 1 Yes No 8 9 1 1
A:A:D295 O:O:?1 5.82 1 No Yes 9 0 1 0
A:A:E299 A:A:L296 6.63 0 No No 6 6 2 1
A:A:L296 O:O:?1 2.97 0 No Yes 6 0 1 0
A:A:C365 A:A:T369 3.38 1 Yes No 8 9 1 2
A:A:C365 O:O:?1 2.55 1 Yes Yes 8 0 1 0
A:A:A366 O:O:?1 4.22 1 No Yes 9 0 1 0
A:A:V367 O:O:?1 5.59 1 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:G49 O:O:?1 1.83 0 No Yes 8 0 1 0
A:A:C365 A:A:D368 1.56 1 Yes No 8 9 1 2
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub4.00
Average Interaction Strength4.55
Average Nodes In Shell33.00
Average Hubs In Shell9.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGB A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GGB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:D173 A:A:E50 6.5 4 No No 9 9 1 2
A:A:E50 A:A:R201 3.49 0 No No 9 9 2 1
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:K53 A:A:S51 6.12 4 Yes No 9 9 1 2
A:A:S51 A:A:V247 4.85 4 No Yes 9 7 2 2
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 12.44 0 No Yes 9 9 2 1
A:A:K53 A:A:V247 3.04 4 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 9.06 4 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 4 No No 9 9 1 1
A:A:T55 O:O:?1 6.32 4 No Yes 9 0 1 0
A:A:D173 A:A:K293 5.53 4 No Yes 9 9 1 1
A:A:D173 O:O:?1 2.91 4 No Yes 9 0 1 0
A:A:C174 A:A:F178 11.17 4 No Yes 9 7 1 2
A:A:C174 A:A:R199 5.57 4 No Yes 9 7 1 1
A:A:C174 O:O:?1 2.55 4 No Yes 9 0 1 0
A:A:F178 A:A:Y177 5.16 0 Yes No 7 9 2 2
A:A:R199 A:A:Y177 12.35 4 Yes No 7 9 1 2
A:A:L198 A:A:V367 2.98 0 Yes No 9 9 2 1
A:A:R199 A:A:V367 2.62 4 Yes No 7 9 1 1
A:A:R199 O:O:?1 3.25 4 Yes Yes 7 0 1 0
A:A:R201 O:O:?1 5.21 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 4.43 4 Yes Yes 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 4.59 4 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 4 Yes No 6 9 1 2
A:A:K293 A:A:N292 8.39 4 Yes Yes 9 9 1 1
A:A:A366 A:A:N292 4.69 4 No Yes 9 9 1 1
A:A:N292 O:O:?1 5.15 4 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 5.29 4 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 4 No Yes 9 6 1 1
A:A:C365 A:A:D295 3.11 4 No No 8 9 1 1
A:A:D295 O:O:?1 8 4 No Yes 9 0 1 0
A:A:E299 A:A:L296 3.98 0 No Yes 6 6 2 1
A:A:L296 O:O:?1 2.97 4 Yes Yes 6 0 1 0
A:A:C365 O:O:?1 3.4 4 No Yes 8 0 1 0
A:A:A366 O:O:?1 4.22 4 No Yes 9 0 1 0
A:A:V367 O:O:?1 5.59 4 No Yes 9 0 1 0
A:A:C365 A:A:D368 1.56 4 No No 8 9 1 2
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.00
Average Nodes In Shell28.00
Average Hubs In Shell9.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGC A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GGC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 1 Yes No 9 8 1 2
A:A:G52 A:A:S51 3.71 1 No No 9 9 1 1
A:A:K53 A:A:S51 4.59 1 Yes No 9 9 1 1
A:A:S51 O:O:?1 3.22 1 No Yes 9 0 1 0
A:A:G52 O:O:?1 6.41 1 No Yes 9 0 1 0
A:A:D223 A:A:K53 6.91 1 No Yes 9 9 2 1
A:A:K53 O:O:?1 11.33 1 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 3.22 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 1 No No 9 9 1 1
A:A:T55 O:O:?1 4.74 1 No Yes 9 0 1 0
A:A:C174 A:A:D173 3.11 1 Yes No 9 9 2 1
A:A:D173 A:A:K293 4.15 1 No Yes 9 9 1 1
A:A:D173 O:O:?1 10.9 1 No Yes 9 0 1 0
A:A:C174 A:A:R199 2.79 1 Yes Yes 9 7 2 2
A:A:R199 A:A:V367 6.54 1 Yes No 7 9 2 1
A:A:L203 A:A:R201 6.07 0 No No 7 9 2 1
A:A:R201 O:O:?1 7.81 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 4.43 1 Yes No 9 7 1 2
A:A:K293 A:A:S251 6.12 1 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 0 No No 6 9 2 2
A:A:K293 A:A:N292 2.8 1 Yes Yes 9 9 1 1
A:A:A366 A:A:N292 4.69 1 No Yes 9 9 1 1
A:A:N292 O:O:?1 6.62 1 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 10.57 1 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 1 No No 9 6 1 2
A:A:C365 A:A:D295 4.67 1 No No 8 9 1 1
A:A:D295 O:O:?1 7.27 1 No Yes 9 0 1 0
A:A:C365 A:A:D368 6.22 1 No No 8 9 1 2
A:A:C365 O:O:?1 3.4 1 No Yes 8 0 1 0
A:A:A366 O:O:?1 4.22 1 No Yes 9 0 1 0
A:A:D368 A:A:V367 2.92 0 No No 9 9 2 1
A:A:V367 O:O:?1 7.98 0 No Yes 9 0 1 0
A:A:T204 O:O:?1 0.79 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.32
Average Nodes In Shell24.00
Average Hubs In Shell6.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGE A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GGE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 0 No No 9 8 1 2
A:A:G52 A:A:S51 1.86 0 No No 9 9 1 2
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 9.68 0 Yes No 9 9 2 1
A:A:K53 O:O:?1 6.8 0 No Yes 9 0 1 0
A:A:D223 A:A:S54 4.42 0 Yes No 9 9 2 1
A:A:S54 O:O:?1 5.63 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 1 No No 9 9 1 1
A:A:T55 O:O:?1 6.32 1 No Yes 9 0 1 0
A:A:D173 A:A:L296 4.07 0 No Yes 9 6 1 2
A:A:D173 O:O:?1 12.36 0 No Yes 9 0 1 0
A:A:R199 A:A:V367 3.92 15 Yes No 7 9 2 1
A:A:R201 O:O:?1 7.81 0 No Yes 9 0 1 0
A:A:K293 A:A:S251 7.65 1 No No 9 9 1 2
A:A:L296 A:A:S251 6.01 1 Yes No 6 9 2 2
A:A:N292 A:A:T364 4.39 1 No No 9 9 1 2
A:A:A366 A:A:N292 4.69 1 No No 9 9 1 1
A:A:N292 O:O:?1 3.68 1 No Yes 9 0 1 0
A:A:K293 A:A:L296 5.64 1 No Yes 9 6 1 2
A:A:K293 O:O:?1 6.04 1 No Yes 9 0 1 0
A:A:D295 A:A:L296 4.07 1 Yes Yes 9 6 1 2
A:A:D295 A:A:E299 3.9 1 Yes No 9 6 1 2
A:A:C365 A:A:D295 3.11 1 No Yes 8 9 1 1
A:A:D295 O:O:?1 5.09 1 Yes Yes 9 0 1 0
A:A:E299 A:A:L296 5.3 1 No Yes 6 6 2 2
A:A:C365 A:A:D368 3.11 1 No No 8 9 1 2
A:A:C365 O:O:?1 2.55 1 No Yes 8 0 1 0
A:A:A366 O:O:?1 3.38 1 No Yes 9 0 1 0
A:A:V367 O:O:?1 11.97 0 No Yes 9 0 1 0
A:A:Q195 A:A:V367 1.43 0 No No 8 9 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.35
Average Nodes In Shell23.00
Average Hubs In Shell5.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GGF A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8GGF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:E50 A:A:R201 8.14 2 Yes No 9 9 2 1
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 2.77 1 No Yes 9 9 2 1
A:A:K53 A:A:V224 3.04 1 Yes Yes 9 9 1 2
A:A:K53 O:O:?1 11.33 1 Yes Yes 9 0 1 0
A:A:D223 A:A:S54 4.42 1 No No 9 9 2 1
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 5.53 0 No Yes 9 0 1 0
A:A:C174 A:A:D173 3.11 0 No No 9 9 2 1
A:A:D173 A:A:K293 4.15 1 No Yes 9 9 1 1
A:A:D173 O:O:?1 13.81 1 No Yes 9 0 1 0
A:A:Q195 A:A:Y177 2.25 1 No Yes 8 9 2 2
A:A:R199 A:A:Y177 24.69 1 No Yes 7 9 1 2
A:A:Q195 A:A:R199 2.34 1 No No 8 7 2 1
A:A:Q195 A:A:V367 2.87 1 No No 8 9 2 1
A:A:R199 O:O:?1 3.9 1 No Yes 7 0 1 0
A:A:L203 A:A:R201 6.07 0 No No 7 9 2 1
A:A:R201 O:O:?1 7.16 0 No Yes 9 0 1 0
A:A:D223 A:A:V224 2.92 1 No Yes 9 9 2 2
A:A:K293 A:A:S251 3.06 1 Yes Yes 9 9 1 2
A:A:L296 A:A:S251 6.01 1 Yes Yes 6 9 1 2
A:A:K293 A:A:L296 2.82 1 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 6.04 1 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 1 No Yes 9 6 1 1
A:A:C365 A:A:D295 6.22 1 No No 8 9 1 1
A:A:D295 O:O:?1 4.36 1 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.22 1 Yes Yes 6 0 1 0
A:A:C365 O:O:?1 2.55 1 No Yes 8 0 1 0
A:A:V367 O:O:?1 5.59 0 No Yes 9 0 1 0
A:A:G47 A:A:K53 1.74 0 No Yes 9 9 2 1
A:A:A366 O:O:?1 1.69 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 1.61 0 No Yes 8 9 2 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.92
Average Nodes In Shell24.00
Average Hubs In Shell8.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNL A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 7.05 0 Yes Yes 9 8 1 2
A:A:E50 A:A:G49 3.27 0 No No 9 8 2 1
A:A:G49 O:O:?1 3.66 0 No Yes 8 0 1 0
A:A:G52 A:A:S51 3.71 9 No No 9 9 1 1
A:A:S51 A:A:V247 4.85 9 No No 9 7 1 2
A:A:S51 O:O:?1 2.41 9 No Yes 9 0 1 0
A:A:G52 O:O:?1 7.33 9 No Yes 9 0 1 0
A:A:D223 A:A:K53 5.53 0 No Yes 9 9 2 1
A:A:K53 O:O:?1 5.29 0 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 8.69 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 4.43 9 Yes No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 9 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 9 Yes No 6 9 1 2
A:A:K293 A:A:N292 2.8 9 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 4.39 9 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 7.36 9 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 4.23 9 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 12.84 9 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 9 No Yes 9 6 1 1
A:A:D295 O:O:?1 5.09 9 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 9 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 5.06 0 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:G47 A:A:K53 1.74 0 No Yes 9 9 2 1
A:A:C365 A:A:D295 1.56 0 No No 8 9 2 1
A:A:I56 A:A:N292 1.42 0 No Yes 7 9 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.18
Average Nodes In Shell23.00
Average Hubs In Shell7.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNM A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 0 No No 9 8 1 2
A:A:E50 O:O:?1 8.52 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 8.3 0 No No 9 9 2 1
A:A:K53 O:O:?1 6.8 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 8.85 0 No Yes 9 0 1 0
A:A:Q59 A:A:T55 2.83 0 No No 9 9 2 1
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 14 Yes No 9 9 1 2
A:A:L296 A:A:S251 9.01 14 Yes No 6 9 1 2
A:A:K293 A:A:N292 2.8 14 Yes No 9 9 1 2
A:A:K293 A:A:L296 12.69 14 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 12.09 14 Yes Yes 9 0 1 0
A:A:D295 A:A:E299 5.2 0 No No 9 6 2 2
A:A:C365 A:A:D295 3.11 0 Yes No 8 9 1 2
A:A:E299 A:A:L296 5.3 0 No Yes 6 6 2 1
A:A:L296 O:O:?1 3.71 14 Yes Yes 6 0 1 0
A:A:C365 A:A:D368 4.67 0 Yes No 8 9 1 2
A:A:C365 O:O:?1 3.4 0 Yes Yes 8 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:C365 A:A:V367 1.71 0 Yes No 8 9 1 2
A:A:T55 O:O:?1 1.58 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.97
Average Nodes In Shell20.00
Average Hubs In Shell4.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNN A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 7 Yes No 9 8 1 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 A:A:G49 4.91 0 No No 9 8 1 2
A:A:E50 A:A:R265 6.98 0 No Yes 9 9 1 2
A:A:E50 O:O:?1 3.55 0 No Yes 9 0 1 0
A:A:G52 A:A:S51 3.71 7 No Yes 9 9 1 1
A:A:K53 A:A:S51 3.06 7 Yes Yes 9 9 1 1
A:A:S51 A:A:V247 4.85 7 Yes No 9 7 1 2
A:A:S51 O:O:?1 3.22 7 Yes Yes 9 0 1 0
A:A:G52 O:O:?1 5.5 7 No Yes 9 0 1 0
A:A:D223 A:A:K53 2.77 0 No Yes 9 9 2 1
A:A:K53 A:A:V247 3.04 7 Yes No 9 7 1 2
A:A:K53 O:O:?1 6.8 7 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 11.26 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 3.16 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 7 No No 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 4.59 7 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 7 No No 6 9 1 2
A:A:K293 A:A:N292 4.2 7 Yes No 9 9 1 1
A:A:N292 O:O:?1 5.15 7 No Yes 9 0 1 0
A:A:K293 O:O:?1 13.6 7 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 4.07 7 No No 9 6 1 1
A:A:D295 O:O:?1 6.54 7 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 7 No Yes 6 0 1 0
A:A:A366 O:O:?1 5.06 0 No Yes 9 0 1 0
A:A:I56 A:A:T55 1.52 0 No No 7 9 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.07
Average Nodes In Shell21.00
Average Hubs In Shell5.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNO A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 0 Yes No 9 8 1 2
A:A:G49 O:O:?1 3.66 0 No Yes 8 0 1 0
A:A:G52 O:O:?1 5.5 0 No Yes 9 0 1 0
A:A:K53 O:O:?1 3.02 0 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 4.83 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 3.16 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 18 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 0 No No 6 9 2 2
A:A:K293 A:A:N292 5.6 18 Yes No 9 9 1 1
A:A:N292 O:O:?1 2.94 18 No Yes 9 0 1 0
A:A:K293 O:O:?1 9.06 18 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 0 No No 9 6 1 2
A:A:D295 O:O:?1 10.18 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 6.75 0 No Yes 9 0 1 0
A:A:G52 A:A:S51 1.86 0 No No 9 9 1 2
A:A:G47 A:A:K53 1.74 0 No Yes 9 9 2 1
A:A:K58 A:A:T55 1.5 0 No No 9 9 2 1
A:A:Q59 A:A:T55 1.42 0 No No 9 9 2 1
A:A:D223 A:A:K53 1.38 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.46
Average Nodes In Shell19.00
Average Hubs In Shell3.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNP A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:S51 A:A:V247 4.85 0 No No 9 7 2 2
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 3.22 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 11.05 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 7.08 10 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 10 Yes No 9 7 1 2
A:A:K293 A:A:S251 3.06 10 No No 9 9 1 2
A:A:K293 A:A:N292 6.99 10 No Yes 9 9 1 1
A:A:N292 A:A:T364 4.39 10 Yes No 9 9 1 2
A:A:N292 O:O:?1 5.15 10 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 19.64 10 No Yes 9 0 1 0
A:A:A366 O:O:?1 5.06 0 No Yes 9 0 1 0
A:A:A366 A:A:V367 1.7 0 No No 9 9 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.42
Average Nodes In Shell13.00
Average Hubs In Shell2.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNQ A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 0 No Yes 9 8 1 2
A:A:E50 O:O:?1 4.97 0 No Yes 9 0 1 0
A:A:G52 A:A:S51 3.71 8 No No 9 9 1 1
A:A:S51 A:A:V247 4.85 8 No No 9 7 1 2
A:A:S51 O:O:?1 3.22 8 No Yes 9 0 1 0
A:A:G52 A:A:N292 3.39 8 No Yes 9 9 1 1
A:A:G52 O:O:?1 5.5 8 No Yes 9 0 1 0
A:A:D223 A:A:K53 11.06 0 No No 9 9 2 1
A:A:K53 O:O:?1 3.78 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 4.74 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 5.66 0 No Yes 7 9 2 1
A:A:N292 A:A:V247 2.96 8 Yes No 9 7 1 2
A:A:K293 A:A:S251 6.12 8 No No 9 9 1 2
A:A:L296 A:A:S251 6.01 8 No No 6 9 2 2
A:A:K293 A:A:N292 2.8 8 No Yes 9 9 1 1
A:A:N292 O:O:?1 8.09 8 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 12.09 8 No Yes 9 0 1 0
A:A:D295 A:A:L296 2.71 8 No No 9 6 1 2
A:A:D295 A:A:E299 10.39 8 No No 9 6 1 2
A:A:D295 O:O:?1 5.09 8 No Yes 9 0 1 0
A:A:E299 A:A:L296 5.3 8 No No 6 6 2 2
A:A:A366 O:O:?1 3.38 0 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:G49 O:O:?1 1.83 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.37
Average Nodes In Shell20.00
Average Hubs In Shell3.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNR A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 7.05 4 No Yes 9 8 1 2
A:A:D223 A:A:L45 6.79 4 No Yes 9 8 2 2
A:A:E50 O:O:?1 6.39 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 13.83 4 No No 9 9 2 1
A:A:K53 O:O:?1 3.02 4 No Yes 9 0 1 0
A:A:S54 O:O:?1 7.24 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 4.74 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 4 No No 9 7 1 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 4 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 4 Yes No 6 9 1 2
A:A:K293 A:A:N292 4.2 4 Yes No 9 9 1 1
A:A:N292 O:O:?1 5.88 4 No Yes 9 0 1 0
A:A:K293 O:O:?1 18.88 4 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 4 No Yes 9 6 1 1
A:A:D295 O:O:?1 7.27 4 No Yes 9 0 1 0
A:A:E299 A:A:L296 3.98 0 No Yes 6 6 2 1
A:A:L296 O:O:?1 2.97 4 Yes Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:G52 A:A:S51 1.86 0 No No 9 9 1 2
A:A:R228 O:O:?1 0.65 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.15
Average Nodes In Shell19.00
Average Hubs In Shell4.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNS A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No No 9 9 2 1
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:E50 A:A:R265 3.49 0 No Yes 9 9 1 2
A:A:E50 O:O:?1 3.55 0 No Yes 9 0 1 0
A:A:K53 A:A:S51 3.06 0 No No 9 9 1 2
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:K53 O:O:?1 6.04 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 8.04 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 10.26 0 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 19 Yes No 7 7 2 2
A:A:I56 A:A:N292 4.25 19 Yes No 7 9 2 1
A:A:N292 A:A:V247 2.96 19 No No 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No No 8 9 2 1
A:A:K293 A:A:S251 6.12 0 No No 9 9 1 2
A:A:L296 A:A:S251 3 0 No No 6 9 2 2
A:A:N292 O:O:?1 3.68 19 No Yes 9 0 1 0
A:A:K293 O:O:?1 7.55 0 No Yes 9 0 1 0
A:A:D295 A:A:L296 4.07 0 No No 9 6 1 2
A:A:D295 O:O:?1 5.82 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 3.38 0 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:C365 A:A:D295 1.56 0 No No 8 9 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.75
Average Nodes In Shell21.00
Average Hubs In Shell3.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNT A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 1 No Yes 9 8 1 2
A:A:D223 A:A:L45 6.79 1 Yes Yes 9 8 2 2
A:A:E50 A:A:G49 4.91 0 No No 9 8 2 1
A:A:G49 O:O:?1 3.66 0 No Yes 8 0 1 0
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 2.77 1 Yes No 9 9 2 1
A:A:K53 O:O:?1 3.02 1 No Yes 9 0 1 0
A:A:S54 A:A:T55 3.2 1 No No 9 9 1 1
A:A:S54 O:O:?1 11.26 1 No Yes 9 0 1 0
A:A:T55 O:O:?1 7.11 1 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 1 No No 9 7 1 2
A:A:K293 A:A:S251 4.59 1 Yes No 9 9 1 2
A:A:L296 A:A:S251 4.5 1 Yes No 6 9 1 2
A:A:K293 A:A:N292 2.8 1 Yes No 9 9 1 1
A:A:N292 O:O:?1 3.68 1 No Yes 9 0 1 0
A:A:K293 A:A:L296 4.23 1 Yes Yes 9 6 1 1
A:A:K293 O:O:?1 19.64 1 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 1 No Yes 9 6 1 1
A:A:C365 A:A:D295 3.11 1 No No 8 9 1 1
A:A:D295 O:O:?1 4.36 1 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 1 Yes Yes 6 0 1 0
A:A:C365 O:O:?1 3.4 1 No Yes 8 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:A366 A:A:Q59 1.52 0 No No 9 9 1 2
A:A:E299 A:A:L296 1.33 0 No Yes 6 6 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.17
Average Nodes In Shell20.00
Average Hubs In Shell5.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell20.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNU A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 0 Yes No 9 8 1 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:E50 O:O:?1 4.26 0 No Yes 9 0 1 0
A:A:G52 A:A:S51 3.71 0 No No 9 9 1 2
A:A:K53 A:A:S51 3.06 0 Yes No 9 9 1 2
A:A:S51 A:A:V247 4.85 0 No No 9 7 2 2
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:K53 O:O:?1 5.29 0 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 9.65 0 No Yes 9 0 1 0
A:A:Q59 A:A:T55 4.25 0 No No 9 9 2 1
A:A:A366 A:A:T55 3.36 14 No No 9 9 1 1
A:A:T55 O:O:?1 6.32 14 No Yes 9 0 1 0
A:A:I56 A:A:N292 5.66 0 No No 7 9 2 1
A:A:N292 A:A:V247 2.96 0 No No 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No No 8 9 2 1
A:A:K293 A:A:S251 4.59 0 No No 9 9 1 2
A:A:L296 A:A:S251 6.01 14 No No 6 9 1 2
A:A:N292 O:O:?1 5.15 0 No Yes 9 0 1 0
A:A:K293 O:O:?1 9.06 0 No Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 14 No No 9 6 1 1
A:A:C365 A:A:D295 4.67 0 No No 8 9 2 1
A:A:D295 O:O:?1 7.27 14 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 14 No Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 14 No Yes 9 0 1 0
A:A:E50 A:A:G49 1.64 0 No No 9 8 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub1.00
Average Interaction Strength6.06
Average Nodes In Shell21.00
Average Hubs In Shell2.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNV A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.3 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNV
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 4.23 4 Yes No 9 8 1 2
A:A:G47 A:A:S51 1.86 4 No Yes 9 9 2 1
A:A:G47 A:A:K53 3.49 4 No Yes 9 9 2 1
A:A:G52 A:A:S51 3.71 4 No Yes 9 9 1 1
A:A:K53 A:A:S51 9.18 4 Yes Yes 9 9 1 1
A:A:S51 A:A:V247 4.85 4 Yes No 9 7 1 2
A:A:S51 O:O:?1 3.22 4 Yes Yes 9 0 1 0
A:A:G52 A:A:T55 1.82 4 No No 9 9 1 1
A:A:G52 O:O:?1 6.41 4 No Yes 9 0 1 0
A:A:K53 A:A:V247 4.55 4 Yes No 9 7 1 2
A:A:K53 O:O:?1 7.55 4 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 10.46 0 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 4 No No 9 9 1 1
A:A:T55 O:O:?1 3.95 4 No Yes 9 0 1 0
A:A:A249 A:A:K293 6.42 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 9.18 4 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 4 No No 6 9 1 2
A:A:K293 A:A:N292 6.99 4 Yes No 9 9 1 1
A:A:N292 A:A:T364 4.39 4 No Yes 9 9 1 2
A:A:N292 O:O:?1 8.83 4 No Yes 9 0 1 0
A:A:K293 O:O:?1 3.78 4 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 5.43 4 No No 9 6 1 1
A:A:D295 O:O:?1 6.54 4 No Yes 9 0 1 0
A:A:L296 O:O:?1 3.71 4 No Yes 6 0 1 0
A:A:C365 A:A:V367 1.71 0 No No 8 9 1 2
A:A:A366 O:O:?1 4.22 4 No Yes 9 0 1 0
A:A:C365 O:O:?1 1.7 0 No Yes 8 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.49
Average Nodes In Shell19.00
Average Hubs In Shell5.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNW A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 6.97 0 No Yes 9 9 2 1
A:A:E50 A:A:G49 3.27 0 No Yes 9 8 2 1
A:A:G49 O:O:?1 2.75 0 Yes Yes 8 0 1 0
A:A:G52 A:A:S51 3.71 3 No Yes 9 9 1 1
A:A:K53 A:A:S51 6.12 3 Yes Yes 9 9 1 1
A:A:S51 A:A:V247 4.85 3 Yes Yes 9 7 1 2
A:A:S51 O:O:?1 2.41 3 Yes Yes 9 0 1 0
A:A:G52 O:O:?1 5.5 3 No Yes 9 0 1 0
A:A:K53 A:A:V247 3.04 3 Yes Yes 9 7 1 2
A:A:K53 O:O:?1 3.02 3 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:I56 A:A:T55 3.04 3 Yes No 7 9 2 1
A:A:T55 O:O:?1 7.9 0 No Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 3 Yes Yes 7 7 2 2
A:A:I56 A:A:N292 7.08 3 Yes Yes 7 9 2 2
A:A:N292 A:A:V247 2.96 3 Yes Yes 9 7 2 2
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 7.65 3 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 3 Yes No 6 9 2 2
A:A:K293 A:A:N292 2.8 3 Yes Yes 9 9 1 2
A:A:K293 A:A:L296 2.82 3 Yes Yes 9 6 1 2
A:A:K293 O:O:?1 6.04 3 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 0 No Yes 9 6 1 2
A:A:D295 O:O:?1 4.36 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 2.53 0 No Yes 9 0 1 0
A:A:A48 A:A:G49 1.95 0 No Yes 8 8 2 1
A:A:G49 A:A:R228 1.5 0 Yes No 8 9 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength4.55
Average Nodes In Shell20.00
Average Hubs In Shell9.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNX A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 2.82 0 No No 9 8 1 2
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:E50 O:O:?1 7.1 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:K53 O:O:?1 6.04 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 5.63 0 No Yes 9 0 1 0
A:A:I56 A:A:T55 3.04 8 Yes No 7 9 2 1
A:A:T55 O:O:?1 4.74 0 No Yes 9 0 1 0
A:A:I56 A:A:N292 7.08 8 Yes Yes 7 9 2 1
A:A:I56 A:A:T364 3.04 8 Yes Yes 7 9 2 2
A:A:N292 A:A:V247 2.96 8 Yes No 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 8 Yes No 9 9 1 2
A:A:L296 A:A:S251 7.51 0 No No 6 9 1 2
A:A:K293 A:A:N292 5.6 8 Yes Yes 9 9 1 1
A:A:N292 A:A:T364 2.92 8 Yes Yes 9 9 1 2
A:A:N292 O:O:?1 2.94 8 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 10.57 8 Yes Yes 9 0 1 0
A:A:E299 A:A:L296 3.98 0 No No 6 6 2 1
A:A:L296 O:O:?1 2.97 0 No Yes 6 0 1 0
A:A:A366 O:O:?1 5.91 0 No Yes 9 0 1 0
A:A:G47 A:A:K53 1.74 0 No No 9 9 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub2.00
Average Interaction Strength5.32
Average Nodes In Shell19.00
Average Hubs In Shell5.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNY A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No No 9 9 2 1
A:A:G52 A:A:S51 3.71 12 No No 9 9 1 2
A:A:K53 A:A:S51 3.06 0 No No 9 9 1 2
A:A:G52 A:A:T55 3.64 12 No Yes 9 9 1 1
A:A:G52 O:O:?1 3.66 12 No Yes 9 0 1 0
A:A:K53 O:O:?1 7.55 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 8.04 0 No Yes 9 0 1 0
A:A:I56 A:A:T55 4.56 0 No Yes 7 9 2 1
A:A:Q59 A:A:T55 14.17 0 No Yes 9 9 2 1
A:A:T55 O:O:?1 14.21 12 Yes Yes 9 0 1 0
A:A:K293 A:A:S251 6.12 12 No No 9 9 1 2
A:A:L296 A:A:S251 4.5 12 No No 6 9 2 2
A:A:K293 A:A:L296 9.87 12 No No 9 6 1 2
A:A:K293 O:O:?1 15.86 12 No Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 0 No No 9 6 1 2
A:A:D295 O:O:?1 6.54 0 No Yes 9 0 1 0
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub1.00
Average Interaction Strength8.58
Average Nodes In Shell14.00
Average Hubs In Shell2.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UNZ A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.8 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UNZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 0 No No 9 8 1 2
A:A:G47 A:A:K53 3.49 0 No No 9 9 2 1
A:A:G52 O:O:?1 4.58 0 No Yes 9 0 1 0
A:A:K53 O:O:?1 10.57 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 15.28 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 15.79 0 No Yes 9 0 1 0
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 7.65 14 Yes No 9 9 1 2
A:A:K293 A:A:N292 5.6 14 Yes No 9 9 1 2
A:A:K293 A:A:L296 2.82 14 Yes No 9 6 1 1
A:A:K293 O:O:?1 12.09 14 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 8.14 14 No No 9 6 1 1
A:A:C365 A:A:D295 7.78 0 No No 8 9 2 1
A:A:D295 O:O:?1 8 14 No Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 14 No Yes 6 0 1 0
A:A:A366 A:A:C365 1.81 0 No No 9 8 1 2
A:A:A366 O:O:?1 3.38 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub1.00
Average Interaction Strength9.08
Average Nodes In Shell15.00
Average Hubs In Shell2.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO0 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UO0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:K53 A:A:L45 5.64 2 Yes Yes 9 8 1 2
A:A:D223 A:A:L45 16.29 2 Yes Yes 9 8 2 2
A:A:G47 A:A:K53 3.49 0 No Yes 9 9 2 1
A:A:A48 A:A:G49 1.95 2 No Yes 8 8 2 1
A:A:A48 A:A:S51 1.71 2 No Yes 8 9 2 1
A:A:E50 A:A:G49 1.64 2 No Yes 9 8 1 1
A:A:G49 A:A:S51 1.86 2 Yes Yes 8 9 1 1
A:A:G49 O:O:?1 3.66 2 Yes Yes 8 0 1 0
A:A:E50 A:A:K293 4.05 2 No Yes 9 9 1 1
A:A:E50 O:O:?1 8.52 2 No Yes 9 0 1 0
A:A:S51 A:A:V247 3.23 2 Yes No 9 7 1 2
A:A:S51 O:O:?1 1.61 2 Yes Yes 9 0 1 0
A:A:G52 A:A:N292 1.7 0 No Yes 9 9 1 2
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 2.77 2 Yes Yes 9 9 2 1
A:A:K53 O:O:?1 6.8 2 Yes Yes 9 0 1 0
A:A:S54 O:O:?1 8.04 0 No Yes 9 0 1 0
A:A:T55 O:O:?1 1.58 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 0 Yes No 9 7 2 2
A:A:A249 A:A:S252 3.42 2 No No 8 8 2 2
A:A:A249 A:A:K293 6.42 2 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 2 Yes No 9 9 1 2
A:A:L296 A:A:S251 7.51 2 No No 6 9 1 2
A:A:K293 A:A:S252 4.59 2 Yes No 9 8 1 2
A:A:K293 O:O:?1 18.13 2 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 8.14 2 No No 9 6 1 1
A:A:C365 A:A:D295 3.11 0 Yes No 8 9 2 1
A:A:D295 O:O:?1 6.54 2 No Yes 9 0 1 0
A:A:L296 O:O:?1 5.93 2 No Yes 6 0 1 0
A:A:A366 A:A:C365 1.81 0 No Yes 9 8 1 2
A:A:A366 O:O:?1 4.22 0 No Yes 9 0 1 0
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.49
Average Nodes In Shell22.00
Average Hubs In Shell9.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO1 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP; Mg Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UO1
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No No 9 9 2 1
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:E50 A:A:R265 6.98 0 No Yes 9 9 1 2
A:A:E50 O:O:?1 2.84 0 No Yes 9 0 1 0
A:A:G52 O:O:?1 6.41 0 No Yes 9 0 1 0
A:A:K53 O:O:?1 4.53 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 6.43 0 No Yes 9 0 1 0
A:A:L198 A:A:T55 8.84 0 Yes No 9 9 2 1
A:A:A366 A:A:T55 3.36 8 Yes No 9 9 1 1
A:A:T55 O:O:?1 4.74 8 No Yes 9 0 1 0
A:A:D173 A:A:I172 4.2 0 No Yes 9 7 1 2
A:A:D173 O:O:?1 11.63 0 No Yes 9 0 1 0
A:A:R199 A:A:Y177 17.49 8 Yes No 7 9 1 2
A:A:L198 A:A:Q195 3.99 0 Yes No 9 8 2 2
A:A:Q195 A:A:R199 14.02 8 No Yes 8 7 2 1
A:A:Q195 A:A:V367 2.87 8 No No 8 9 2 1
A:A:R199 A:A:V367 2.62 8 Yes No 7 9 1 1
A:A:R199 O:O:?1 5.86 8 Yes Yes 7 0 1 0
A:A:L203 A:A:R201 13.36 0 No No 7 9 2 1
A:A:R201 O:O:?1 9.76 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 8 Yes No 9 7 1 2
A:A:K293 A:A:N292 4.2 8 No Yes 9 9 1 1
A:A:A366 A:A:N292 4.69 8 Yes Yes 9 9 1 1
A:A:N292 O:O:?1 7.36 8 Yes Yes 9 0 1 0
A:A:K293 A:A:L296 2.82 8 No No 9 6 1 2
A:A:K293 O:O:?1 16.62 8 No Yes 9 0 1 0
A:A:C365 A:A:D295 6.22 0 No No 8 9 1 2
A:A:C365 O:O:?1 3.4 0 No Yes 8 0 1 0
A:A:A366 O:O:?1 4.22 8 Yes Yes 9 0 1 0
A:A:V367 O:O:?1 4.79 8 No Yes 9 0 1 0
I:I:?402 O:O:?1 2.85 0 No Yes 0 0 1 0
A:A:A48 A:A:G49 1.95 0 No No 8 8 2 1
A:A:A366 A:A:I56 1.62 8 Yes No 9 7 1 2
StatisticsValue
Average Number Of Links15.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.28
Average Nodes In Shell28.00
Average Hubs In Shell7.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO2 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP Gs/Beta1/Gamma2 3.6 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UO2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:K53 3.49 0 No No 9 9 2 1
A:A:A48 A:A:G49 1.95 0 Yes No 8 8 2 1
A:A:A48 A:A:S51 1.71 0 Yes No 8 9 2 2
A:A:G49 O:O:?1 2.75 0 No Yes 8 0 1 0
A:A:D173 A:A:E50 3.9 3 Yes No 9 9 1 1
A:A:E50 A:A:K293 8.1 3 No Yes 9 9 1 1
A:A:E50 O:O:?1 9.94 3 No Yes 9 0 1 0
A:A:K53 A:A:S51 3.06 0 No No 9 9 1 2
A:A:G52 A:A:T55 1.82 3 No Yes 9 9 1 1
A:A:G52 O:O:?1 5.5 3 No Yes 9 0 1 0
A:A:K53 O:O:?1 8.31 0 No Yes 9 0 1 0
A:A:S54 O:O:?1 8.85 0 No Yes 9 0 1 0
A:A:L198 A:A:T55 4.42 0 No Yes 9 9 2 1
A:A:A366 A:A:T55 3.36 3 No Yes 9 9 1 1
A:A:T55 O:O:?1 8.69 3 Yes Yes 9 0 1 0
A:A:I56 A:A:V247 3.07 3 Yes No 7 7 2 2
A:A:I56 A:A:N292 2.83 3 Yes Yes 7 9 2 1
A:A:D173 A:A:K293 2.77 3 Yes Yes 9 9 1 1
A:A:D173 O:O:?1 18.9 3 Yes Yes 9 0 1 0
A:A:R199 O:O:?1 14.32 0 No Yes 7 0 1 0
A:A:R201 O:O:?1 7.16 0 No Yes 9 0 1 0
A:A:N292 A:A:V247 2.96 3 Yes No 9 7 1 2
A:A:A249 A:A:K293 4.82 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 3.06 3 Yes No 9 9 1 2
A:A:L296 A:A:S251 4.5 0 No No 6 9 1 2
A:A:N292 A:A:T364 2.92 3 Yes No 9 9 1 2
A:A:A366 A:A:N292 4.69 3 No Yes 9 9 1 1
A:A:N292 O:O:?1 3.68 3 Yes Yes 9 0 1 0
A:A:K293 O:O:?1 4.53 3 Yes Yes 9 0 1 0
A:A:L296 O:O:?1 2.97 0 No Yes 6 0 1 0
A:A:A366 O:O:?1 4.22 3 No Yes 9 0 1 0
A:A:D173 A:A:I172 1.4 3 Yes No 9 7 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.68
Average Nodes In Shell24.00
Average Hubs In Shell7.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO3 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP; Mg Gs/Beta1/Gamma2 3.5 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UO3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:E50 A:A:R201 11.63 0 No No 9 9 2 1
A:A:G52 O:O:?1 8.25 0 No Yes 9 0 1 0
A:A:D223 A:A:K53 4.15 0 No No 9 9 2 1
A:A:K53 O:O:?1 11.33 0 No Yes 9 0 1 0
A:A:D223 A:A:S54 2.94 0 No No 9 9 2 1
A:A:S54 I:I:?402 5.78 4 No No 9 0 1 1
A:A:S54 O:O:?1 3.22 4 No Yes 9 0 1 0
A:A:A366 A:A:T55 3.36 0 No No 9 9 2 1
A:A:T55 O:O:?1 5.53 0 No Yes 9 0 1 0
A:A:D173 A:A:K293 5.53 4 No Yes 9 9 1 1
A:A:D173 O:O:?1 2.91 4 No Yes 9 0 1 0
A:A:Q195 A:A:R199 5.84 4 No No 8 7 2 2
A:A:Q195 A:A:V367 4.3 4 No No 8 9 2 1
A:A:R199 A:A:V367 7.85 4 No No 7 9 2 1
A:A:L203 A:A:R201 4.86 0 No No 7 9 2 1
A:A:R201 O:O:?1 5.86 0 No Yes 9 0 1 0
A:A:T204 I:I:?402 8.51 0 No No 9 0 2 1
A:A:A249 A:A:K293 3.21 0 No Yes 8 9 2 1
A:A:K293 A:A:S251 6.12 4 Yes No 9 9 1 2
A:A:L296 A:A:S251 6.01 4 No No 6 9 2 2
A:A:K293 A:A:L296 4.23 4 Yes No 9 6 1 2
A:A:K293 O:O:?1 6.8 4 Yes Yes 9 0 1 0
A:A:D295 A:A:L296 6.79 4 No No 9 6 1 2
A:A:C365 A:A:D295 4.67 4 No No 8 9 1 1
A:A:D295 O:O:?1 4.36 4 No Yes 9 0 1 0
A:A:C365 O:O:?1 3.4 4 No Yes 8 0 1 0
A:A:V367 O:O:?1 7.98 4 No Yes 9 0 1 0
I:I:?402 O:O:?1 5.71 4 No Yes 0 0 1 0
A:A:C365 A:A:N371 1.57 4 No No 8 9 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.94
Average Nodes In Shell23.00
Average Hubs In Shell2.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8UO4 A Amine Adrenergic Beta2 Homo Sapiens Constrained Epinephrine GTP; Mg Gs/Beta1/Gamma2 4 2024-03-06 10.1038/s41586-024-07153-1

A 2D representation of the interactions of GTP in 8UO4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:G47 A:A:S51 1.86 2 No Yes 9 9 2 2
A:A:G47 A:A:K53 3.49 2 No Yes 9 9 2 1
A:A:G52 A:A:S51 3.71 2 No Yes 9 9 1 2
A:A:K53 A:A:S51 6.12 2 Yes Yes 9 9 1 2
A:A:G52 A:A:T55 1.82 2 No No 9 9 1 1
A:A:G52 O:O:?1 7.33 2 No Yes 9 0 1 0
A:A:K53 A:A:S54 3.06 2 Yes No 9 9 1 1
A:A:K53 O:O:?1 13.6 2 Yes Yes 9 0 1 0
A:A:D223 A:A:S54 5.89 0 No No 9 9 2 1
A:A:S54 O:O:?1 5.63 2 No Yes 9 0 1 0
A:A:T55 O:O:?1 9.47 2 No Yes 9 0 1 0
A:A:I56 A:A:N292 2.83 2 Yes No 7 9 2 1
A:A:C200 A:A:R201 2.79 0 No No 7 9 1 2
A:A:V202 O:O:?1 11.17 0 No Yes 6 0 1 0
A:A:K293 A:A:S251 10.71 2 Yes No 9 9 1 2
A:A:L296 A:A:S251 9.01 2 Yes No 6 9 2 2
A:A:K293 A:A:N292 5.6 2 Yes No 9 9 1 1
A:A:N292 O:O:?1 5.88 2 No Yes 9 0 1 0
A:A:K293 A:A:L296 5.64 2 Yes Yes 9 6 1 2
A:A:K293 O:O:?1 3.02 2 Yes Yes 9 0 1 0
A:A:C200 A:A:K91 1.62 0 No No 7 5 1 2
A:A:C200 O:O:?1 0.85 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.12
Average Nodes In Shell17.00
Average Hubs In Shell6.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.28
Average Number Of Links With An Hub2.51
Average Interaction Strength6.36
Average Nodes In Shell20.56
Average Hubs In Shell5.19
Average Links In Shell25.53
Average Links Mediated by Hubs In Shell20.19

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)