Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 5.388506
2A:A:R42 5.2775409
3A:A:L43 2.8225417
4A:A:L44 3.525429
5A:A:K53 6.092509
6A:A:I56 2.916517
7A:A:M60 3.356519
8A:A:H64 13.6575418
9A:A:Y169 5.795406
10A:A:F178 6.3225107
11A:A:R201 7.2419
12A:A:F219 4.988518
13A:A:M221 3.9575408
14A:A:F222 5.82527
15A:A:R232 4.5375428
16A:A:W234 5.71429
17A:A:F238 5.11667629
18A:A:I244 2.1775428
19A:A:I245 3.135407
20A:A:F246 2.9375409
21A:A:N254 5.21679
22A:A:I257 5.454178
23A:A:R258 8.64414
24A:A:W277 6.782506
25A:A:W281 7.506505
26A:A:L282 3.1725429
27A:A:L289 4.265419
28A:A:F290 4.35167619
29A:A:L291 3.775418
30A:A:N292 3.675619
31A:A:K293 4.81619
32A:A:Q294 5.865416
33A:A:L296 3.6425416
34A:A:L297 3.5775418
35A:A:I308 4.7575477
36A:A:F315 10.78476
37A:A:V334 4.76414
38A:A:K338 6.692515
39A:A:F340 5.068577
40A:A:R342 5.45667614
41A:A:F345 5.46667618
42A:A:Y358 5.5275414
43A:A:Y360 6.7575418
44A:A:F363 6.705415
45A:A:C365 5.5775418
46A:A:D378 5.2825417
47A:A:R385 9.494515
48A:A:L393 2.705408
49B:B:I18 4.415407
50B:B:T34 3.7475495
51B:B:V40 3.488593
52B:B:H54 6.754569
53B:B:K57 7.1625429
54B:B:Y59 9.6925428
55B:B:W63 5.354507
56B:B:V71 3.2025408
57B:B:S74 5.115469
58B:B:D76 6.8825469
59B:B:I80 7.0825468
60B:B:W82 8.824569
61B:B:K89 4.06669
62B:B:W99 5.27875829
63B:B:Y105 3.705406
64B:B:Y111 5.3425404
65B:B:L117 3.3375429
66B:B:Y124 4.4506
67B:B:H142 4.74529
68B:B:Y145 3.68528
69B:B:F151 3.495409
70B:B:S160 3.2525446
71B:B:D163 7.7975429
72B:B:T165 4.7225427
73B:B:W169 8.648508
74B:B:F180 5.014547
75B:B:H183 5.91833649
76B:B:F199 5.025649
77B:B:D205 6.055449
78B:B:K209 8.2775446
79B:B:W211 7.866548
80B:B:D212 5.96409
81B:B:F222 6.3875458
82B:B:H225 6.265859
83B:B:D228 6.7525159
84B:B:I232 3.9425458
85B:B:F234 3.8275405
86B:B:F235 4.434297116
87B:B:P236 5.30754117
88B:B:F241 4.58667656
89B:B:T243 4.216558
90B:B:D246 3.16754159
91B:B:D247 6.62459
92B:B:T249 4.3456
93B:B:R251 9.73333658
94B:B:F253 6.32167656
95B:B:Q259 2.355406
96B:B:E260 8.8025456
97B:B:Y264 4.718505
98B:B:F278 3.94117
99B:B:R283 6.136599
100B:B:Y289 5.937147217
101B:B:H311 7.394129
102B:B:R314 10.625428
103B:B:L318 3.245226
104B:B:V327 3.03754226
105B:B:W332 10.172529
106B:B:D333 5.10754129
107B:B:K337 7.754126
108B:B:W339 6.6545129
109G:G:R27 5.3408
110G:G:D48 7.174509
111G:G:L51 5.134596
112G:G:N59 5.88409
113G:G:F61 4.5925408
114R:R:M40 4.27406
115R:R:I47 5.50254198
116R:R:V54 1.58409
117R:R:F61 4.75236
118R:R:F71 3.848508
119R:R:F89 4.31254145
120R:R:W99 5.245147
121R:R:F101 6.1854145
122R:R:W105 5.51254145
123R:R:E107 7.2075485
124R:R:S111 4.885486
125R:R:I121 5.08437
126R:R:E122 2.845405
127R:R:L124 2.89438
128R:R:I127 3.2375409
129R:R:Y132 6.65408
130R:R:Y141 6.43254247
131R:R:F166 4.68484
132R:R:I169 5.46833685
133R:R:Q170 7.2025484
134R:R:Y174 4.798585
135R:R:H178 7.62402
136R:R:F208 5.95286738
137R:R:Y209 4.9375435
138R:R:Y219 4.07509
139R:R:Q229 4.706517
140R:R:K232 6.1175414
141R:R:F282 3.89167639
142R:R:W286 5.87375838
143R:R:L287 2.7725406
144R:R:F289 5.534536
145R:R:F290 7.472537
146R:R:I294 3.9275436
147R:R:I303 3.6825403
148R:R:L311 2.8825405
149R:R:W313 2.98505
150R:R:Y316 6.848536
151R:R:S319 5.824199
152R:R:F332 7.516676139
153M:M:?1 5.641210
154L:L:?1 7.51667930
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:V327 G:G:L50 19.56182.98YesNo069
2B:B:L318 B:B:V327 20.08492.98YesYes2266
3B:B:L318 B:B:S275 65.39784.5YesNo068
4B:B:S275 B:B:T274 65.56954.8NoNo088
5B:B:R314 B:B:T274 65.70745.17YesNo288
6A:A:W281 B:B:R314 72.1924YesYes058
7A:A:N279 A:A:W281 72.86963.39NoYes085
8A:A:I235 A:A:N279 36.52552.83NoNo298
9A:A:I235 A:A:R232 36.60992.51NoYes298
10A:A:L272 A:A:R232 37.27976.07NoYes088
11A:A:F246 A:A:L272 37.44512.44YesNo098
12A:A:F246 A:A:F273 33.10263.22YesNo099
13A:A:F273 A:A:F345 33.4435.36NoYes098
14A:A:F345 A:A:I341 66.22382.51YesNo088
15A:A:I341 A:A:S250 66.23643.1NoNo086
16A:A:L297 A:A:S250 66.24894.5YesNo186
17A:A:L297 A:A:S251 1003YesNo189
18A:A:K293 A:A:S251 98.40417.65YesNo199
19A:A:K293 A:A:N292 97.80412.8YesYes199
20A:A:I56 A:A:N292 34.05022.83YesYes179
21A:A:F290 A:A:I56 32.92642.51YesYes197
22A:A:F290 A:A:I288 48.6613.77YesNo199
23A:A:D378 A:A:I288 48.59212.8YesNo179
24A:A:D378 A:A:Y360 96.89996.9YesYes178
25A:A:R385 A:A:Y360 96.033511.32YesYes158
26A:A:R385 R:R:Q229 94.877811.68YesYes157
27A:A:L388 R:R:Q229 94.32572.66NoYes087
28A:A:L388 A:A:L393 93.89412.77NoYes088
29A:A:L393 A:A:Y391 92.47343.52YesNo084
30A:A:Y391 R:R:R131 92.188217.49NoNo049
31R:R:I127 R:R:R131 84.89832.51YesNo099
32A:A:L282 A:A:N279 36.51564.12YesNo298
33A:A:I244 A:A:L282 36.59441.43YesYes289
34A:A:I244 A:A:L46 36.84381.43YesNo288
35A:A:F246 A:A:L46 61.43092.44YesNo098
36A:A:F246 A:A:L289 65.85193.65YesYes099
37A:A:F345 A:A:L289 33.06646.09YesYes189
38A:A:L289 A:A:L291 32.89644.15YesYes198
39A:A:F363 A:A:L291 32.8194.87YesYes158
40A:A:F363 A:A:Q294 33.4037.03YesYes156
41A:A:L297 A:A:Q294 33.73625.32YesYes186
42A:A:N292 A:A:V247 32.71844.43YesNo197
43A:A:F290 A:A:V247 32.70322.62YesNo197
44A:A:N292 A:A:T364 32.74294.39YesNo099
45A:A:F290 A:A:T364 32.74937.78YesNo099
46A:A:F290 A:A:H362 48.6615.66YesNo199
47A:A:D378 A:A:H362 48.592110.08YesNo179
48B:B:Q75 B:B:W99 10.29585.48NoYes299
49B:B:L252 B:B:Y264 31.71675.86NoYes075
50B:B:L252 B:B:L261 31.53974.15NoNo075
51B:B:L261 G:G:V30 31.00872.98NoNo058
52B:B:Q259 G:G:V30 30.65452.87YesNo068
53B:B:Q259 B:B:R22 30.12333.5YesNo066
54B:B:D258 B:B:R22 28.524311.91NoNo076
55B:B:D258 B:B:Q220 27.64247.83NoNo077
56B:B:L210 B:B:Q220 12.8413.99NoNo057
57B:B:L210 B:B:V200 12.48492.98NoNo056
58B:B:I232 B:B:S189 19.27863.1YesNo087
59B:B:C148 B:B:S189 18.92191.72NoNo067
60B:B:C148 B:B:S160 18.56521.72NoYes066
61B:B:F222 B:B:Q220 14.62457.03YesNo087
62B:B:F222 B:B:F241 10.70126.43YesYes586
63B:B:L318 B:B:T329 37.0282.95YesNo068
64B:B:T329 B:B:W339 37.22468.49NoYes089
65B:B:L308 B:B:W339 37.09467.97NoYes079
66B:B:C294 B:B:L308 36.9193.17NoNo057
67B:B:C294 B:B:G288 36.74353.92NoNo057
68B:B:G288 B:B:Y289 36.3932.9NoYes077
69B:B:W297 B:B:Y264 32.73616.75NoYes085
70B:B:S279 G:G:L50 13.80913NoNo099
71B:B:S279 G:G:D48 13.63757.36NoYes099
72B:B:D333 B:B:N313 13.46064.04YesNo097
73R:R:I127 R:R:Y326 78.71773.63YesNo099
74R:R:L124 R:R:Y326 78.57383.52YesNo089
75R:R:F282 R:R:L124 78.28962.44YesYes398
76R:R:F208 R:R:F282 27.72053.22YesYes389
77R:R:F208 R:R:F290 24.93418.22YesYes387
78L:L:?1 R:R:F290 46.92716.88YesYes307
79R:R:F282 R:R:W286 49.39664.01YesYes398
80R:R:F290 R:R:W286 24.93364.01YesYes378
81R:R:V117 R:R:W286 23.60533.68NoYes068
82L:L:?1 R:R:V117 23.45958.41YesNo006
83L:L:?1 R:R:F193 29.23538.84YesNo004
84R:R:F193 R:R:T195 28.35029.08NoNo043
85R:R:T195 R:R:Y174 27.90774.99NoYes035
86R:R:I169 R:R:Y174 29.24259.67YesYes855
87R:R:I169 R:R:S111 21.2684.64YesYes856
88R:R:F108 R:R:S111 17.72423.96NoYes056
89R:R:F108 R:R:W105 15.06633.01NoYes055
90L:L:?1 R:R:S203 30.56416.06YesNo005
91R:R:S203 R:R:Y199 30.12162.54NoNo056
92R:R:Y174 R:R:Y199 27.90892.98YesNo056
93R:R:Y174 R:R:Y185 20.38362.98YesNo051
94R:R:A181 R:R:Y185 16.83912.67NoNo041
95R:R:A181 R:R:H178 15.9537.32NoYes042
96R:R:F194 R:R:H178 10.63587.92NoYes012
97B:B:W297 B:B:Y289 32.914.82NoYes087
98A:A:L44 A:A:L46 24.50554.15YesNo298
99A:A:F222 A:A:L44 10.7973.65YesYes279
100A:A:F238 A:A:L44 13.64564.87YesYes299
101B:B:N313 B:B:W332 14.66394.52NoYes079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 3 No No 7 7 1 2
R:R:V86 R:R:Y316 6.31 3 No Yes 7 6 2 1
R:R:F193 R:R:T110 2.59 0 No No 4 4 1 2
R:R:D113 R:R:Y316 9.2 3 No Yes 7 6 1 1
L:L:?1 R:R:D113 16.42 3 Yes No 0 7 0 1
R:R:V117 R:R:W286 3.68 0 No Yes 6 8 1 2
L:L:?1 R:R:V117 8.41 3 Yes No 0 6 0 1
R:R:F193 R:R:T195 9.08 0 No No 4 3 1 2
L:L:?1 R:R:F193 8.84 3 Yes No 0 4 0 1
R:R:S203 R:R:Y199 2.54 0 No No 5 6 1 2
L:L:?1 R:R:S203 6.06 3 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 3 Yes No 7 5 1 2
R:R:F208 R:R:W286 3.01 3 Yes Yes 8 8 2 2
R:R:F208 R:R:F290 18.22 3 Yes Yes 8 7 2 1
R:R:F290 R:R:W286 4.01 3 Yes Yes 7 8 1 2
R:R:F289 R:R:F290 4.29 3 Yes Yes 6 7 1 1
R:R:F289 R:R:Y308 5.16 3 Yes No 6 5 1 2
R:R:F289 R:R:L311 2.44 3 Yes Yes 6 5 1 2
R:R:F289 R:R:N312 10.87 3 Yes No 6 5 1 1
L:L:?1 R:R:F289 4.91 3 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 6.88 3 Yes Yes 0 7 0 1
L:L:?1 R:R:N293 3.32 3 Yes No 0 5 0 1
R:R:N312 R:R:Y316 13.96 3 No Yes 5 6 1 1
L:L:?1 R:R:N312 9.97 3 Yes No 0 5 0 1
L:L:?1 R:R:Y316 2.84 3 Yes Yes 0 6 0 1
R:R:W313 R:R:Y316 1.93 0 Yes Yes 5 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
90.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
90.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
90.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
88.89Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single3NY8ICI 118-5513NY8-β2-ICI 118-551
81.82Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
81.82Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
81.82Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
81.82Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
81.82Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
81.82Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
81.82Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGJEpinephrine8GGJ-β2-Epinephrine
81.82Single8GGNEpinephrine8GGN-β2-Epinephrine
81.82Single8GGOEpinephrine8GGO-β2-Epinephrine
81.82Single8GGUEpinephrine8GGU-β2-Epinephrine
81.82Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
81.82Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
80.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
80.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
80.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
80.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8GGVEpinephrine8GGV-β2-Epinephrine
80.00Single8GGXEpinephrine8GGX-β2-Epinephrine
80.00Single8GH0Epinephrine8GH0-β2-Epinephrine
80.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
75.00Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
75.00Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
75.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
75.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
75.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
75.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
75.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
75.00Single7XKAEpinephrine7XKA-β2-Epinephrine
75.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
75.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
75.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
75.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
75.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
75.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
75.00Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
72.73Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
72.73Single6TPGEMPA6TPG-OX2-EMPA
72.73Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
72.73Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
72.73Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGIEpinephrine8GGI-β2-Epinephrine
72.73Single8GGKEpinephrine8GGK-β2-Epinephrine
72.73Single8GGMEpinephrine8GGM-β2-Epinephrine
72.73Single8GGPEpinephrine8GGP-β2-Epinephrine
72.73Single8GGTEpinephrine8GGT-β2-Epinephrine
72.73Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
72.73Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
70.00Single3PBLEticlopride3PBL-D3-Eticlopride
70.00Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
70.00Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
70.00Single8GGSEpinephrine8GGS-β2-Epinephrine
70.00Single8GGYEpinephrine8GGY-β2-Epinephrine
70.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
70.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
69.23Single2YDVNECA2YDV-A2A-NECA
69.23Single4UHRCGS216804UHR-A2A-CGS21680
69.23Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
69.23Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
69.23Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
69.23Single5G53NECA5G53-A2A-NECA-Gs
69.23Single6H7JIsoprenaline6H7J-β1-Isoprenaline
69.23Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
69.23Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
69.23Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
69.23Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
69.23Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
69.23Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
69.23Consensusa2_onOrthosteric Liganda2a_on a2b_on
69.23Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
69.23Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
69.23Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
69.23Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
69.23Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
66.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
66.67Single2Y04Salbutamol2Y04-β1-Salbutamol
66.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
66.67Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
66.67Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
66.67Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
66.67Single6H7MSalbutamol6H7M-β1-Salbutamol
66.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
66.67Single6PS1Timolol6PS1-β2-Timolol
66.67Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
66.67Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
66.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
66.67Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
66.67Single7UL4Alvimopan7UL4-μ-Alvimopan
66.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
66.67Single8JJOAlprenolol8JJO-β2-Alprenolol
66.67Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
66.67Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
66.67Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
66.67Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
66.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
64.29Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
64.29Single4AMIBucindolol4AMI-β1-Bucindolol
64.29Single4LDEBI1671074LDE-β2-BI167107
64.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
64.29Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single8JJ8Formoterol8JJ8-β2-Formoterol
64.29Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
64.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
63.64Single6KUXRS-799486KUX-α2a-RS-79948
63.64Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
63.64Single6TODEMPA6TOD-OX1-EMPA-Na
63.64Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
63.64Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
63.64Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
63.64Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
63.64Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8GGWEpinephrine8GGW-β2-Epinephrine
63.64Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
63.64Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
63.64Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
63.64Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
63.64Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
63.64Consensusalpha1_onOrthosteric Ligandalpha1a_on
63.64Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
63.64Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
63.64Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
63.64Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
61.54Single2Y03Isoprenaline2Y03-β1-Isoprenaline
61.54Single5C1MBU725C1M-μ-BU72
61.54Single5TVNLSD5TVN-5-HT2B-LSD
61.54Single5WQCEMPA5WQC-OX2-EMPA
61.54Single6E67BI1671076E67-β2-BI167107-Gs (fused)
61.54Single6PS6Timolol6PS6-β2-Timolol
61.54Single7WC6LSD7WC6-5-HT2A-LSD
61.54Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
61.54Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
61.54Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
61.54Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
61.54Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
61.54Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
61.54Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
61.54Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
61.54Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
60.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
60.00Single3UZAGTPL92363UZA-A2A-GTPL9236
60.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
60.00Single6H7LDobutamine6H7L-β1-Dobutamine
60.00Single6IBLArformoterol6IBL-β1-Arformoterol
60.00Single8GGREpinephrine8GGR-β2-Epinephrine
60.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
60.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
60.00Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
58.33Single2YDOAdenosine2YDO-A2A-Adenosine
58.33Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
58.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
58.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
58.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
58.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
58.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
58.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
58.33Single8GGLEpinephrine8GGL-β2-Epinephrine
58.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
58.33Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
58.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
58.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
58.33Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
58.33Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
58.33Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
57.14Single3P0GBI1671073P0G-β2-BI167107
57.14Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
57.14Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
57.14Single4RWADIPP-NH24RWA-δ-DIPP-NH2
57.14Single6J21Aprepitant6J21-NK1-Aprepitant
57.14Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
57.14Single6WGTLSD6WGT-5-HT2A-LSD
57.14Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
57.14Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
57.14Single8E0GBU728E0G-μ-BU72
57.14Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
57.14Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
57.14Consensus5ht5_offOrthosteric Ligand5ht5a_off
57.14Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
57.14Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
57.14Consensushistamine_offOrthosteric Ligandh1_off
56.25Single3NY9PubChem 9131033NY9-β2-PubChem 913103
56.25Single4UG2CGS216804UG2-A2A-CGS21680
54.55Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
54.55Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
54.55Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
54.55Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
54.55Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
54.55Single8GH1Epinephrine8GH1-β2-Epinephrine
54.55Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
54.55Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
54.55Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
54.55Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
53.85Single2Y01Dobutamine2Y01-β1-Dobutamine
53.85Single2Y02Carmoterol2Y02-β1-Carmoterol
53.85Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.85Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
53.85Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
53.85Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
53.85Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.85Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.85Single6TOTLemborexant6TOT-OX1-Lemborexant
53.85Single7BU7BI1671077BU7-β1-BI167107
53.85Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
53.85Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
53.85Single7WC7Lisuride7WC7-5-HT2A-Lisuride
53.85Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
53.85Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
53.85Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.85Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
53.85Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
53.85Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
53.85Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
53.85Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
53.85Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8X64Desloratadine8X64-H1-Desloratadine
53.85Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.85Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.85Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.85Consensusadenosine_onOrthosteric Liganda1_on a2_on
53.85Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.85Consensusnucleotide_onOrthosteric Ligandadenosine_on
53.85Consensustar_onOrthosteric Ligandta1_on
53.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
53.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
53.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
53.33Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
53.33Single6MXTSalmeterol6MXT-β2-Salmeterol
53.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
53.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
53.33Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single7YITNalfurafine7YIT-κ-Nalfurafine
53.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
53.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
53.33Single8JJLOlodaterol8JJL-β2-Olodaterol
53.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
53.33Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
53.33Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
53.33Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
52.94Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
52.94Single4IARErgotamine4IAR-5-HT1B-Ergotamine
52.94Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
52.94Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Single2Y00Dobutamine2Y00-β1-Dobutamine
50.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
50.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5WIUNemonapride5WIU-D4-Nemonapride
50.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
50.00Single5WS3EMPA5WS3-OX2-EMPA
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
50.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
50.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
50.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
50.00Single6TP6Filorexant6TP6-OX1-Filorexant
50.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
50.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
50.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
50.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
50.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
50.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8IWESpermidine8IWE-TAAR9-Spermidine
50.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
50.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
50.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
50.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
50.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
50.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
50.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
50.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
50.00Consensussensory_onOrthosteric Ligandopsin_on
47.06Single5WF6UK-4320975WF6-A2A-UK-432097
47.06Single6PT3DPI-2876PT3-δ-DPI-287
47.06Single7XN9L-054,5227XN9-SST2-L-054,522
47.06Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8X5YAstemizole8X5Y-H1-Astemizole
46.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
46.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
46.67Single4U15Tiotropium4U15-M3-Tiotropium
46.67Single5V54Methiothepin5V54-5-HT1B-Methiothepin
46.67Single5X93K-87945X93-ETB-K-8794
46.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
46.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
46.67Single6OL9Tiotropium6OL9-M5-Tiotropium
46.67Single6TQ7SB-3348676TQ7-OX1-SB-334867
46.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
46.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
46.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
46.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
46.67Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
46.67Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
46.67Consensus5ht1_offOrthosteric Ligand5ht1b_off
46.67Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
46.67Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
46.67Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
46.67Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
46.67Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
46.15Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
46.15Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.15Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.15Single6A94Zotepine6A94-5-HT2A-Zotepine
46.15Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
46.15Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
46.15Single6TPNHTL66416TPN-OX2-HTL6641
46.15Single6V9SGTPL114036V9S-OX1-GTPL11403
46.15Single6VI4JDTic6VI4-κ-JDTic
46.15Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
46.15Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
46.15Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
46.15Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
46.15Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
46.15Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
46.15Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.15Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
46.15Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
46.15Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
46.15Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
46.15Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
46.15Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
45.45Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
45.45Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
45.45Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
45.45Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
45.45Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
45.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
44.44Single5MZPCaffeine5MZP-A2A-Caffeine-Na
44.44Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
43.75Single5CXVTiotropium5CXV-M1-Tiotropium
43.75Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
43.75Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
43.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
43.75Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
43.75Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
42.86Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
42.86Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
42.86Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
42.86Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
42.86Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
42.86Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
42.86Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
42.86Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
42.86Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
42.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
42.86Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
42.86Single8CU6LJ-45178CU6-A2A-LJ-4517
42.86Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
42.86Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
42.86Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
42.86Single8X63Mepyramine8X63-H1-Mepyramine
42.86Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
42.86Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
42.86Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
42.86Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
42.86Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
42.86Consensushistamine_onOrthosteric Ligandh1_on h4_on
42.11Single3QAKUK-4320973QAK-A2A-UK-432097
42.11Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
42.11Single6HLOAprepitant6HLO-NK1-Aprepitant
42.11Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
41.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
41.67Single6HLLCP999946HLL-NK1-CP99994
41.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
41.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
41.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
41.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Single7SRQLSD7SRQ-5-HT2B-LSD
41.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
41.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
41.67Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
41.67Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
41.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
41.67Single8K5BNiacin8K5B-HCA2-Niacin
41.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
41.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
41.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
41.18Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
41.18Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
41.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
41.18Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
41.18Single7EZCUKA7EZC-A2A-UKA
41.18Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
41.18Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
41.18Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
41.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
41.18Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
40.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
40.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
40.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
40.00Single5WF5UK-4320975WF5-A2A-UK-432097
40.00Single5XPRBosentan5XPR-ETB-Bosentan
40.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
40.00Single6PT2KGCHM076PT2-δ-KGCHM07
40.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
40.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.00Single7SINNPS-21437SIN-CaS-NPS-2143
40.00Single7SINNPS-21437SIN-CaS-NPS-2143
40.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
40.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
40.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
40.00Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
40.00Single8PWNTheophylline8PWN-A2A-Theophylline
40.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
40.00Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
40.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single7SK9CCX6627SK9-ACKR3-CCX662
38.89Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
38.89Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.46Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
38.46Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
38.46Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
38.46Single4S0VSuvorexant4S0V-OX2-Suvorexant
38.46Single5DHHSB-6121115DHH-NOP-SB-612111
38.46Single5K2DZM2413855K2D-A2A-ZM241385
38.46Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
38.46Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
38.46Single6AKYMaraviroc6AKY-CCR5-Maraviroc
38.46Single6B73PubChem 1319551386B73-κ-PubChem 131955138
38.46Single6JZHZM2413856JZH-A2A-ZM241385-Na
38.46Single6ME2Ramelteon6ME2-MT1-Ramelteon
38.46Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
38.46Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.46Single6PS7ZM2413856PS7-A2A-ZM241385-Na
38.46Single6TPJSuvorexant6TPJ-OX2-Suvorexant
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7F8ULintitript7F8U-CCKA-Lintitript
38.46Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
38.46Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
38.46Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
38.46Single7XRRLemborexant7XRR-OX2-Lemborexant
38.46Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
38.46Single8GNGIstradefylline8GNG-A2A-Istradefylline
38.46Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
38.46Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
38.46Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
38.46Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensusgt_class-aOrthosteric Ligandgt_opsin
38.46Consensusgt_opsinOrthosteric Ligandgt_sensory
38.46Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.46Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single4DJHJDTic4DJH-κ-JDTic
37.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
37.50Single6J20Aprepitant6J20-NK1-Aprepitant
37.50Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
37.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
37.50Single7EPENAM5637EPE-mGlu-NAM563
37.50Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
37.50Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
37.50Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
37.50Single7W41PD1762527W41-BB2-PD176252
37.50Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
37.50Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
37.50Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
37.50Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
37.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
37.50Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
37.50Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
37.50Consensusadenosine_offOrthosteric Liganda1_off a2_off
37.50Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
37.50Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
37.50Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
37.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
37.50Consensusbombesin_offOrthosteric Ligandbb2_off
37.50Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
37.50Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
36.84Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.84Single7F8XNN90567F8X-CCKA-NN9056
36.84Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
36.84Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
36.84Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.84Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.84Consensussst_onOrthosteric Ligandsst2_on sst4_on
36.36Single3RFMCaffeine3RFM-A2A-Caffeine
36.36Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
36.36Single8A2OTheophylline8A2O-A2A-Theophylline-Na
36.36Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
36.36Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
35.71Single3REYPubChem 56973REY-A2A-PubChem 5697
35.71Single3RZECidoxepin3RZE-H1-Cidoxepin
35.71Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
35.71Single5IU4ZM2413855IU4-A2A-ZM241385-Na
35.71Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.71Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.71Single5JTBZM2413855JTB-A2A-ZM241385
35.71Single5K2BZM2413855K2B-A2A-ZM241385-Na
35.71Single5K2CZM2413855K2C-A2A-ZM241385-Na
35.71Single5NLXZM2413855NLX-A2A-ZM241385-Na
35.71Single5NM4ZM2413855NM4-A2A-ZM241385-Na
35.71Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
35.71Single6AQFZM2413856AQF-A2A-ZM241385
35.71Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.71Single6IQLL7458706IQL-D4-L745870
35.71Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
35.71Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.71Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
35.71Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.71Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
35.71Single7AROLUF58337ARO-A2A-LUF5833-Na
35.71Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
35.71Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
35.71Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
35.71Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.71Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
35.71Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.71Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
35.71Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
35.71Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.71Single8K5CAcipimox8K5C-HCA2-Acipimox
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
35.71Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.71Consensushcar_onOrthosteric Ligandhca_on
35.71Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
35.71Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
35.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.29Single6A93Risperidone6A93-5-HT2A-Risperidone
35.29Single6CM4Risperidone6CM4-D2-Risperidone
35.29Single6HLPNetupitant6HLP-NK1-Netupitant
35.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.29Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
35.29Single7DFPSpiperone7DFP-D2-Spiperone
35.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
35.29Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.29Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
35.29Single8JWZAB9288JWZ-A2A-AB928-Na
35.29Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
35.29Consensusgi_class-fOther Ligandgi_frizzled
35.29Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
35.29Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.29Consensusgs_steroidOrthosteric Ligandgs_bileacid
35.29Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.29Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
35.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
35.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
34.78Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
34.78Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single3EMLZM2413853EML-A2A-ZM241385
33.33Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single4DAJTiotropium4DAJ-M3-Tiotropium
33.33Single4EIYZM2413854EIY-A2A-ZM241385-Na
33.33Single4MQSIperoxo4MQS-M2-Iperoxo
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4U14Tiotropium4U14-M3-Tiotropium
33.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
33.33Single5DSGTiotropium5DSG-M4-Tiotropium
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM2413855K2A-A2A-ZM241385-Na
33.33Single5OLGZM2413855OLG-A2A-ZM241385-Na
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
33.33Single5VRAZM2413855VRA-A2A-ZM241385-Na
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6LPJZM2413856LPJ-A2A-ZM241385-Na
33.33Single6LPKZM2413856LPK-A2A-ZM241385-Na
33.33Single6S0LZM2413856S0L-A2A-ZM241385
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
33.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
33.33Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
33.33Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
33.33Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
33.33Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
33.33Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
33.33Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
33.33Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensussteroid_onOrthosteric Ligandbileacid_on
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
32.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
32.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
31.82Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
31.82Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.82Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Single5ZTYAM102575ZTY-CB2-AM10257
31.58Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
31.58Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
31.58Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.58Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.58Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
31.58Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
31.58Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
31.58Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.58Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
31.58Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single5CGCHTL142425CGC-mGlu5-HTL14242
31.25Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.25Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
31.25Single5N2SPSB365N2S-A1-PSB36
31.25Single5NM2ZM2413855NM2-A2A-ZM241385-Na
31.25Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.25Single6LPLZM2413856LPL-A2A-ZM241385-Na
31.25Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single6S0QZM2413856S0Q-A2A-ZM241385
31.25Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.25Single6WQAZM2413856WQA-A2A-ZM241385-Na
31.25Single7RM5ZM2413857RM5-A2A-ZM241385-Na
31.25Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
31.25Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.25Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single8EA0Iperoxo8EA0-M3-Iperoxo
31.25Single8FYNZM2413858FYN-A2A-ZM241385-Na
31.25Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.25Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.25Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.25Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.25Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
30.77Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
30.77Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
30.77Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
30.77Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
30.77Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
30.77Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
30.77Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.77Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
30.43Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
30.43Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.43Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
30.00Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
30.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
30.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
30.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.00Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.41Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
29.41Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
29.41Single6E59L-7607356E59-NK1-L-760735
29.41Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
29.41Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.41Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
29.41Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
29.41Single7PX4PSB-21137PX4-A2A-PSB-2113
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
29.41Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
29.41Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
29.41Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
29.41Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
29.41Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
29.41Consensuscck_onOrthosteric Ligandccka_on cckb_on
29.41Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
29.41Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
29.41Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.41Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
29.41Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
29.41Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.17Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
29.17Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
28.57Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
28.57Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
28.57Single3PWHZM2413853PWH-A2A-ZM241385
28.57Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
28.57Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.57Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
28.57Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.57Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
28.57Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.57Single8IHKAcifran8IHK-HCA3-Acifran
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
28.57Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
28.57Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
28.57Consensusmglu_onOther Ligandmglu2_on mglu4_on
28.57Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
28.57Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
27.78Single4N4WSANT-14N4W-SMO-SANT-1
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Single7K15MKD0467K15-BLT1-MKD046-Na
27.78Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.78Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.78Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
27.78Single8WU1KCA8WU1-CB1-KCA-Arrestin1
27.78Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
27.78Consensusblt_offOrthosteric Ligandblt1_off
27.78Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
27.78Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.78Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
27.27Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
27.27Consensusangiotensin_onOrthosteric Ligandat1_on
27.27Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.92Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.67Single5UVIZM2413855UVI-A2A-ZM241385
26.67Single6MH8ZM2413856MH8-A2A-ZM241385
26.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
26.67Single6TPKRetosiban6TPK-OT-Retosiban
26.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.67Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.67Single7T32ZM2413857T32-A2A-ZM241385
26.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.67Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.67Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.67Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
26.67Consensussensory_offOrthosteric Ligandopsin_off
26.67Consensusvasopressin-ot_offOrthosteric Ligandot_off
26.32Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.32Single5CGDHTL142425CGD-mGlu5-HTL14242
26.32Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
26.32Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
26.32Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.32Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.32Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
26.32Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.32Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.32Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.09Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.09Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.09Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
26.09Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.09Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6D27CAY104716D27-DP2-CAY10471
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
25.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
25.00Consensusleuko_onOrthosteric Ligandblt_on
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
24.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
23.81Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.81Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
23.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.81Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
23.53Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
23.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.53Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
23.53Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
23.53Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
23.53Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
23.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.53Single8QOTNanobody E8QOT-μ-Nanobody E
23.53Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.08Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.08Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.08Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
23.08Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
23.08Single6ME5Agomelatine6ME5-MT1-Agomelatine
23.08Single6ME9Ramelteon6ME9-MT2-Ramelteon
23.08Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.08Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
23.08Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.08Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.08Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.08Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.73Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
22.73Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
22.22Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
22.22Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
22.22Single5XR8AM8415XR8-CB1-AM841
22.22Single5XRAAM115425XRA-CB1-AM11542
22.22Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
22.22Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.22Single7P2L4YI7P2L-mGlu5-4YI
22.22Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
22.22Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
22.22Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
22.22Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.22Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
22.22Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.22Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
22.22Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
22.22Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
22.22Consensuschemerin_onOrthosteric Ligandcml1_on
22.22Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.22Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
22.22Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.74Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
21.74Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.74Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.43Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
21.43Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
21.43Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
21.43Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
21.43Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
21.43Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.43Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
21.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.05Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
21.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
21.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.05Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.05Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
21.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Consensusclass-b2_onOrthosteric Ligandadgrg_on
21.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.05Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
21.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
21.05Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.83Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.83Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
20.83Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
20.83Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
20.69Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
20.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
20.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
20.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
20.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
20.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
20.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
20.00Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
20.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
20.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
20.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
20.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
20.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
20.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
19.35Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.23Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
19.23Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
19.23Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.23Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.05Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
19.05Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.05Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
19.05Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
19.05Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.75Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
18.75Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.75Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
18.75Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
18.75Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
18.75Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
18.75Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
18.75Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
18.75Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.75Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
18.75Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.75Consensusgnrh_offOrthosteric Ligandgnrh1_off
18.75Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
18.75Consensuss1p_offOrthosteric Ligands1p1_off
18.52Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
18.52Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
18.52Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.52Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
18.52Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.52Consensusgo_class-b1Orthosteric Ligandgo_crf
18.52Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
18.18Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
18.18Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7QA8Peptide7QA8-STE2-Peptide
18.18Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
18.18Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
18.18Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
17.86Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.86Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.86Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.65Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6FFHFenobam6FFH-mGlu5-Fenobam
17.65Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
17.65Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
17.65Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
17.65Single6GPSMK08126GPS-CCR2-MK0812
17.65Single6IIVDaltroban6IIV-TP-Daltroban
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
17.65Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
17.65Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
17.65Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.65Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.65Consensushcar_offOrthosteric Ligandsuccinate_off
17.65Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
17.65Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
17.65Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
17.65Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
17.65Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
17.39Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
17.39Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
17.39Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.24Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
16.67Single4NTJAZD12834NTJ-P2Y12-AZD1283
16.67Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
16.67Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
16.67Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
16.67Single6GPXMK08126GPX-CCR2-MK0812
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
16.67Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
16.67Single7C4SS1P7C4S-S1P3-S1P
16.67Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.67Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.67Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
16.67Consensusclass-c_onOther Ligandgabab_on mglu_on
16.67Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
16.67Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
16.67Consensusep_offOrthosteric Ligandep4_off
16.67Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
16.67Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
16.13Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
16.13Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
16.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
16.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
16.00Consensusclass-d_onOrthosteric Ligandste2_on
16.00Consensusgi_class-dOrthosteric Ligandgi_ste
16.00Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.79Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
15.79Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
15.79Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
15.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.79Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.62Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.38Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
15.38Single6TQ9SB-4081246TQ9-OX1-SB-408124
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
15.38Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
15.38Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
15.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
15.38Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
15.15Consensuspth_onOrthosteric Ligandpth1_on pth2_on
15.00Single5X33BIIL2605X33-BLT1-BIIL260
15.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
15.00Single6IIURamatroban6IIU-TP-Ramatroban
15.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
15.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
15.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
15.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
15.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
15.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
14.81Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.81Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
14.81Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
14.81Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
14.29Single3OE6IT1t3OE6-CXCR4-IT1t
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
14.29Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
14.29Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
14.29Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
14.29Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
14.29Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single6LMLGlucagon6LML-Glucagon-Glucagon
13.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
13.79Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
13.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.79Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.64Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.64Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
13.64Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
13.64Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
13.64Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusclass-d_offOrthosteric Ligandste2_off
13.64Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.64Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.64Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
13.51Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
13.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusclass-t_onOrthosteric Ligandtaste2_on
13.33Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
13.33Consensusgo_class-b2Orthosteric Ligandgo_adhesion
13.33Consensusgs_class-tOrthosteric Ligandgs_taste
13.33Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.33Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
13.16Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
13.16Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
13.04Single4XT1Fractalkine4XT1-US28-Fractalkine
13.04Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
13.04Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
13.04Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.04Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
13.04Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
12.90Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.90Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.50Single3ODUIT1t3ODU-CXCR4-IT1t
12.50Single5U09Taranabant5U09-CB1-Taranabant
12.50Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.50Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.50Single7F8YDevazepide7F8Y-CCKA-Devazepide
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7SK5CXCL127SK5-ACKR3-CXCL12
12.50Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
12.50Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
12.50Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
12.50Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
12.50Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
12.50Consensussst_offOrthosteric Ligandsst2_off
12.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
12.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.12Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
12.00Single3OE0CVX153OE0-CXCR4-CVX15
12.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Single7XNACYN1548067XNA-SST2-CYN154806
12.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
12.00Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.76Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.76Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
11.76Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.76Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.76Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.76Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
11.76Single8K2WAMG4878K2W-CXCR3-AMG487
11.76Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
11.76Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
11.54Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.54Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
11.54Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
11.54Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
11.11Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
11.11Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
11.11Single7F83PF-051904577F83-Ghrelin-PF-05190457
11.11Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
11.11Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
11.11Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
11.11Consensusclass-c_offOther Ligandgabab_off mglu_off
11.11Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
10.81Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.81Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.71Single4XT3Fractalkine4XT3-US28-Fractalkine
10.71Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.71Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.71Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.71Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.53Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.53Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
10.53Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.34Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.34Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
10.34Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.34Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
10.34Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.34Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.34Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.00Single5V56TC1145V56-SMO-TC114
10.00Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
10.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
10.00Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
10.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
10.00Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
9.68Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single4XEENeurotensin4XEE-NTS1-Neurotensin
9.52Single4XESNeurotensin4XES-NTS1-Neurotensin
9.52Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
9.52Single6OS2TRV0266OS2-AT1-TRV026
9.52Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.52Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
9.52Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
9.52Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
9.52Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
9.52Consensusnts_offOrthosteric Ligandnts1_off
9.38Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
9.09Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
9.09Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
9.09Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
9.09Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
9.09Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
9.09Consensuscyslt_offOrthosteric Ligandcyslt2_off
9.09Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.82Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.82Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.70Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.70Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.70Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.70Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
8.70Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.70Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
8.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
8.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.33Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
8.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.11Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
8.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
8.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
8.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
8.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.69Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.69Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.69Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
7.41Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.41Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
7.14Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
7.14Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
7.14Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.90Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.67Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.67Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.45Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.45Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
6.45Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
6.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.88Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.88Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.88Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.88Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.88Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.56Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.56Single6ZINSR486926ZIN-NTS1-SR48692
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.56Single7VV6C48/807VV6-MRGPRX2-C48/80
5.56Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.41Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.26Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.26Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.26Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.26Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
5.00Single6Z4SSR486926Z4S-NTS1-SR48692
5.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.76Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.76Single5TZR-5TZR-FFA1 (GPR40)-MK8666
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.76Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.76Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.76Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.76Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.76Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
4.55Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.55Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.55Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single7SHEPI; PE7SHE-GPR158-PI; PE
4.55Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.55Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
4.55Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Consensuschemokine_offOrthosteric Ligandcxcr_off
4.55Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.55Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.55Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.55Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Consensusnts_onOrthosteric Ligandnts1_on
4.35Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.35Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.35Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.35Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.12Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.03Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.03Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.94Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.86Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.86Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.78Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.63Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.44Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 8GG9
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand Epinephrine
Other Ligand(s) GTP
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.4
Date 2024-03-06
D.O.I. 10.1038/s41586-024-07153-1
Net Summary
Imin 2.44
Number of Linked Nodes 930
Number of Links 1095
Number of Hubs 154
Number of Links mediated by Hubs 581
Number of Communities 25
Number of Nodes involved in Communities 233
Number of Links involved in Communities 332
Path Summary
Number Of Nodes in MetaPath 102
Number Of Links MetaPath 101
Number of Shortest Paths 16041076
Length Of Smallest Path 3
Average Path Length 52.2307
Length of Longest Path 86
Minimum Path Strength 1.19
Average Path Strength 4.8058
Maximum Path Strength 21.92
Minimum Path Correlation 0.7
Average Path Correlation 0.997511
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 28.3741
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.6745
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeGTP
PDB ResiduesM:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeGTP
NameGuanosine-5'-Triphosphate
SynonymsGuanosine-5'-Triphosphate
Identifier[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
FormulaC10 H16 N5 O14 P3
Molecular Weight523.18
SMILESc1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
PubChem5280317
Formal Charge0
Total Atoms48
Total Chiral Atoms4
Total Bonds50
Total Aromatic Bonds5

CodeG1I
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG1I
Name(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
Synonyms
Identifier(5~{R},6~{R})-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
FormulaC11 H15 N O3
Molecular Weight209.242
SMILESCN[C@@H]1CCc2c(ccc(c2O)O)[C@H]1O
PubChem12353638
Formal Charge0
Total Atoms30
Total Chiral Atoms2
Total Bonds31
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8GG9_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG AGESGKSTI 
VKQMRILHV NATKVQDIK NNLKEAIET IVAAMSNRA CYERSNEYQ 
LIDCAQYFL DDQDLLRCR VLTSGIFET KFQVDKVNF HMFDVGGQR 
DERRKWIQC FNDVTAIIF VVASSSYNM VIREDNQTN RLQEALNLF 
KSIWNNRWL RTISVILFL NKQDLLAEK VLAGKSKIE DYFPEFARY 
TTPEDATPE PEDPRVTRA KYFIRDEFL RISTASGDG RHYCYPHFT 
CAVDTENIR RVFNDCRDI IQRMHLRQY ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8GG9_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8GG9_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP07550
Sequence
>8GG9_Chain_R
VWVVGMGIV MSLIVLAIV FGNVLVITA IAKFERLQT VTNYFITSL 
ACADLVMGL AVVPFGAAH ILTKTWTFG NFWCEFWTS IDVLCVTAS 
IETLCVIAV DRYFAITSP FKYQSLLTK NKARVIILM VWIVSGLTS 
FLPIQMHWY RATHQEAIN CYAEETCCD FFTNQAYAI ASSIVSFYV 
PLVIMVFVY SRVFQEAKR QLQKIDKSE GRFEHKALK TLGIIMGTF 
TLCWLPFFI VNIVHVIQD NLIRKEVYI LLNWIGYVN SGFNPLIYC 
RSPDFRIAF QEL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS5AAmineAdrenergicβ2Homo sapiens(S)-Propranolol--2.92019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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