Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 6.2875424
2A:A:N23 5.41427
3A:A:H41 6.472566
4A:A:F219 6.416568
5A:A:F222 10.8425417
6A:A:Q227 5.9425419
7A:A:K233 3.1475419
8A:A:W234 4.94519
9A:A:C237 3.84418
10A:A:F238 5.054519
11A:A:F246 3.395409
12A:A:F273 5.43479
13A:A:W277 5.86167676
14A:A:W281 7.004515
15A:A:L289 4.2525409
16A:A:F290 4.9075449
17A:A:L291 3.8545118
18A:A:K293 4.58754119
19A:A:Y311 7.125406
20A:A:F312 5.30754178
21A:A:E314 5.84254176
22A:A:F315 7.0875406
23A:A:Y318 3.36406
24A:A:P321 4.0575405
25A:A:P326 3.7401
26A:A:K338 4.68405
27A:A:Y339 5.33403
28A:A:F340 6.2954177
29A:A:R342 5.8985184
30A:A:F345 6.198508
31A:A:S349 3.245407
32A:A:G353 3.6425474
33A:A:R356 6.3325472
34A:A:Y360 6.7125448
35A:A:P361 3.554185
36A:A:R373 4.74465
37A:A:F376 3.25429768
38A:A:C379 2.146568
39A:A:H387 4.8875408
40A:A:L388 3.82448
41A:A:Y391 5.03544
42A:A:L393 2.6625448
43B:B:Q6 3.215401
44B:B:I37 3.426582
45B:B:V40 3.78583
46B:B:M45 4.1075414
47B:B:H54 8.304529
48B:B:K57 7.6775419
49B:B:Y59 7.805418
50B:B:W63 4.966527
51B:B:R68 9.5375425
52B:B:S74 5.8125429
53B:B:Q75 9.4575419
54B:B:D76 5.37429
55B:B:K78 4.79408
56B:B:I80 8.1075428
57B:B:W82 7.7575829
58B:B:D83 5.70667628
59B:B:S84 4.5025425
60B:B:Y85 8.114524
61B:B:N88 7.85427
62B:B:K89 5.07833629
63B:B:I93 4.3875417
64B:B:L95 4.665408
65B:B:W99 7.66333619
66B:B:V100 2.8525419
67B:B:Y105 3.62406
68B:B:S108 4.96254126
69B:B:N110 4.214124
70B:B:Y111 4.125124
71B:B:C114 2.25518
72B:B:G115 2.23519
73B:B:L117 3.43419
74B:B:Y124 3.734516
75B:B:H142 5.99286719
76B:B:Y145 4.21125818
77B:B:L146 3.49417
78B:B:C149 2.595408
79B:B:F151 4.294129
80B:B:T159 4.7175419
81B:B:S160 3.232536
82B:B:D163 6.252519
83B:B:W169 7.20571718
84B:B:Q176 6.4414
85B:B:T178 2.95434
86B:B:F180 5.896537
87B:B:H183 7.18857739
88B:B:D186 5.025419
89B:B:F199 5.405439
90B:B:C204 4.8475417
91B:B:D205 7.385439
92B:B:K209 8.474536
93B:B:L210 3.805405
94B:B:W211 7.36667638
95B:B:C218 3.7825435
96B:B:Q220 6.04417
97B:B:F222 7.3418
98B:B:H225 6.772519
99B:B:D228 6.2175419
100B:B:I232 4.015418
101B:B:F234 3.9275415
102B:B:F235 4.73167616
103B:B:N237 3.215415
104B:B:F241 4.555616
105B:B:G244 2.554515
106B:B:D247 8.395419
107B:B:R251 6.352518
108B:B:F253 6.01416
109B:B:R256 4.9625419
110B:B:D258 7.6775417
111B:B:M262 4.436514
112B:B:Y264 4.69143715
113B:B:H266 4.39404
114B:B:C271 4.22415
115B:B:T274 2.625418
116B:B:V276 1.732516
117B:B:F278 5.175417
118B:B:R283 6.622589
119B:B:G288 1.886517
120B:B:Y289 4.85857717
121B:B:D290 4.57167616
122B:B:C294 2.1325415
123B:B:D298 7.4825489
124B:B:K301 5.42485
125B:B:R304 4.5175405
126B:B:A309 2.3875413
127B:B:H311 7.016519
128B:B:R314 9.566518
129B:B:V315 2.7325417
130B:B:T321 4.726527
131B:B:D323 6.86427
132B:B:G324 1.822529
133B:B:T329 3.964508
134B:B:S331 5.8825419
135B:B:W332 8.18714719
136B:B:D333 6.45419
137B:B:L336 3.4175427
138B:B:K337 4.812516
139B:B:W339 5.906519
140G:G:A33 3.11417
141G:G:D48 5.256509
142G:G:P49 3.415407
143G:G:L51 3.606586
144G:G:F61 5.3825428
145L:L:H1 5.055400
146L:L:Q3 3.232590
147L:L:F6 4.62400
148L:L:Y10 5.95400
149L:L:Y13 4.792500
150L:L:F22 5.6125400
151L:L:L26 3.4525450
152R:R:W36 6.41456
153R:R:W83 3.72552
154R:R:Y84 5.37857755
155R:R:L85 4.148556
156R:R:W87 6.816553
157R:R:W115 4.66454
158R:R:F141 4.2725406
159R:R:Q142 6.8575495
160R:R:Y145 4.2797
161R:R:Y149 4.396598
162R:R:L156 3.0145158
163R:R:L166 3.66407
164R:R:F184 5.976676158
165R:R:V191 3.33497
166R:R:D195 5.6475497
167R:R:R201 11.02754144
168R:R:Y202 5.1265141
169R:R:I206 3.9625404
170R:R:W215 10.575142
171R:R:R225 11.0354248
172R:R:Q232 3.395217
173R:R:Y233 44259
174R:R:I235 4.926505
175R:R:N238 7.944159
176R:R:W241 7.204297109
177R:R:L243 4.2725408
178R:R:V244 2.77754108
179R:R:E245 5.18409
180R:R:Y248 3.04408
181R:R:L268 2.544105
182R:R:G271 3.154109
183R:R:P275 3.775259
184R:R:W282 4.756676219
185R:R:W295 11.67254249
186R:R:F303 7.595404
187R:R:W304 9.084506
188R:R:F322 4.7409
189R:R:L329 2.8275449
190R:R:K332 5.7125449
191R:R:H361 6.4375408
192R:R:E362 5.152508
193R:R:D370 3.90754164
194R:R:E371 6.0425405
195R:R:R378 4.6925164
196R:R:G393 2.48254159
197R:R:F402 4.854239
198R:R:R417 4.4825417
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:S84 B:B:W63 12.39354.94YesYes257
2B:B:M61 B:B:W63 29.51423.49NoYes267
3B:B:C317 B:B:M61 30.30524.86NoNo076
4B:B:C317 B:B:S316 38.81043.44NoNo079
5B:B:S316 B:B:W332 39.20793.71NoYes099
6B:B:K57 B:B:W332 13.902513.92YesYes199
7B:B:K57 B:B:Q75 14.21475.42YesYes199
8B:B:Q75 B:B:W99 28.012112.05YesYes199
9B:B:L117 B:B:W99 40.30844.56YesYes199
10A:A:Q227 B:B:L117 43.90583.99YesYes199
11A:A:Q227 B:B:N119 91.60895.28YesNo099
12A:A:G206 B:B:N119 1005.09NoNo089
13A:A:G206 A:A:G226 99.67922.11NoNo089
14A:A:G225 A:A:G226 99.57172.11NoNo099
15A:A:D223 A:A:G225 99.4641.68NoNo099
16A:A:D223 A:A:L45 99.24775.43NoNo098
17A:A:I245 A:A:L45 99.03032.85NoNo078
18A:A:I245 A:A:L43 98.92112.85NoNo077
19A:A:C379 A:A:L43 98.81181.59YesNo087
20A:A:C379 A:A:H41 87.41352.95YesYes686
21A:A:H41 A:A:I383 87.93845.3YesNo068
22A:A:H387 A:A:I383 87.81542.65YesNo088
23A:A:H387 R:R:L252 86.54735.14YesNo088
24R:R:L252 R:R:Y248 86.08174.69NoYes088
25R:R:Y248 R:R:Y267 68.73762.98YesNo087
26R:R:V244 R:R:Y267 68.65882.52YesNo087
27B:B:W332 B:B:Y59 44.27192.89YesYes198
28B:B:Q75 B:B:Y59 13.910115.78YesYes198
29A:A:C237 B:B:Y59 30.62535.38YesYes188
30A:A:C237 B:B:W99 13.92252.61YesYes189
31A:A:C237 A:A:F238 16.89432.79YesYes189
32A:A:F238 A:A:W234 17.33922YesYes199
33A:A:Q227 A:A:W234 22.81525.48YesYes199
34A:A:C379 A:A:F219 10.82372.79YesYes688
35A:A:R231 A:A:W234 21.58416NoYes099
36A:A:L272 A:A:R231 21.44113.64NoNo089
37A:A:F246 A:A:L272 20.72274.87YesNo098
38A:A:F219 A:A:F376 10.21792.14YesYes688
39B:B:K78 B:B:P94 10.98396.69YesNo085
40B:B:I93 B:B:P94 11.36933.39YesNo075
41B:B:C114 B:B:G115 14.01581.96YesYes189
42B:B:G115 B:B:G116 16.78622.11YesNo099
43B:B:G116 B:B:M101 17.69233.49NoNo099
44B:B:D246 B:B:G272 23.78231.68NoNo094
45B:B:D246 B:B:N230 23.83178.08NoNo099
46A:A:K233 B:B:N230 23.88874.2YesNo099
47A:A:K233 B:B:Y145 24.18932.39YesYes198
48A:A:F246 A:A:L289 16.10063.65YesYes099
49A:A:Y391 R:R:Y248 17.44071.99YesYes048
50A:A:Y391 R:R:H177 14.58262.18YesNo449
51G:G:D48 G:G:L51 10.5955.43YesYes096
52B:B:C317 B:B:G330 10.07711.96NoNo075
53B:B:T321 B:B:W63 16.94069.7YesYes277
54B:B:H142 B:B:W169 10.25455.29YesYes198
55B:B:I273 B:B:Y289 11.19314.84NoYes067
56B:B:G324 B:B:T321 15.16231.82YesYes297
57R:R:V244 R:R:W241 65.71263.68YesYes1089
58R:R:S183 R:R:W241 65.44933.71NoYes099
59R:R:N238 R:R:S183 65.29995.96YesNo099
60R:R:K187 R:R:N238 69.20078.39NoYes089
61R:R:I235 R:R:K187 69.0437.27YesNo058
62L:L:H1 R:R:I235 15.05979.28YesYes005
63R:R:E245 R:R:H177 14.50138.62YesNo099
64R:R:E245 R:R:L180 13.02982.65YesNo099
65R:R:F184 R:R:L180 12.88327.31YesNo089
66L:L:Q3 R:R:I235 48.72622.74YesYes005
67L:L:Q3 R:R:L386 14.63872.66YesNo007
68L:L:Q3 R:R:Y145 32.0024.51YesYes907
69L:L:F6 R:R:Y145 14.16483.09YesYes007
70L:L:F6 R:R:L386 14.68084.87YesNo007
71L:L:F6 R:R:Y138 26.81515.16YesNo005
72R:R:Q142 R:R:Y145 16.40057.89YesYes957
73L:L:Y10 R:R:Q142 15.69146.76YesYes005
74L:L:Y13 R:R:Y138 26.09334.96YesNo005
75L:L:R17 L:L:Y13 24.817910.29NoYes000
76R:R:Q232 R:R:W282 11.60027.67YesYes2179
77R:R:K286 R:R:W282 10.03824.64NoYes089
78L:L:E20 L:L:R17 21.78479.3NoNo000
79L:L:E20 R:R:W87 20.02752.18NoYes503
80R:R:L85 R:R:W87 16.55454.56YesYes563
81R:R:L85 R:R:Y84 10.01414.69YesYes565
82A:A:Q227 B:B:Y145 25.01899.02YesYes198
83B:B:C271 B:B:Y289 23.06514.03YesYes157
84B:B:C271 B:B:G272 21.82281.96YesNo154
85B:B:G244 B:B:I273 11.06025.29YesNo056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H1 R:R:Q232 2.47 0 Yes Yes 0 7 0 1
L:L:H1 R:R:I235 9.28 0 Yes Yes 0 5 0 1
L:L:H1 R:R:W304 5.29 0 Yes Yes 0 6 0 1
L:L:S2 R:R:L382 3 0 No No 0 5 0 1
L:L:S2 R:R:D385 5.89 0 No No 0 7 0 1
L:L:S2 R:R:L386 3 0 No No 0 7 0 1
L:L:Q3 R:R:Y145 4.51 9 Yes Yes 0 7 0 1
L:L:Q3 R:R:Y149 3.38 9 Yes Yes 0 8 0 1
L:L:Q3 R:R:V191 2.87 9 Yes Yes 0 7 0 1
L:L:Q3 R:R:I235 2.74 9 Yes Yes 0 5 0 1
L:L:Q3 R:R:L386 2.66 9 Yes No 0 7 0 1
L:L:T5 R:R:D370 7.23 16 No Yes 0 4 0 1
L:L:T5 R:R:R378 2.59 16 No Yes 0 4 0 1
L:L:F6 R:R:Y138 5.16 0 Yes No 0 5 0 1
L:L:F6 R:R:F141 5.36 0 Yes Yes 0 6 0 1
L:L:F6 R:R:Y145 3.09 0 Yes Yes 0 7 0 1
L:L:F6 R:R:L386 4.87 0 Yes No 0 7 0 1
L:L:S8 R:R:N298 7.45 0 No No 0 6 0 1
L:L:D9 R:R:R378 10.72 16 No Yes 0 4 0 1
L:L:Y10 R:R:Y138 2.98 0 Yes No 0 5 0 1
L:L:Y10 R:R:Q142 6.76 0 Yes Yes 0 5 0 1
L:L:Y10 R:R:L198 2.34 0 Yes No 0 6 0 1
L:L:S11 R:R:T296 4.8 0 No No 0 5 0 1
L:L:K12 R:R:S297 4.59 0 No No 0 4 0 1
L:L:Y13 R:R:V134 2.52 0 Yes No 0 2 0 1
L:L:Y13 R:R:A135 2.67 0 Yes No 0 3 0 1
L:L:Y13 R:R:Y138 4.96 0 Yes No 0 5 0 1
L:L:L14 R:R:Y202 12.89 0 No Yes 0 1 0 1
L:L:D15 R:R:G26 1.68 0 No No 0 6 0 1
L:L:D15 R:R:V28 5.84 0 No No 0 3 0 1
L:L:D15 R:R:Y202 2.3 0 No Yes 0 1 0 1
L:L:S16 R:R:P24 3.56 0 No No 0 5 0 1
L:L:R17 R:R:Q131 10.51 0 No No 0 3 0 1
L:L:R18 R:R:Y202 6.17 14 No Yes 0 1 0 1
L:L:R18 R:R:I206 5.01 14 No Yes 0 4 0 1
L:L:R18 R:R:W215 14.99 14 No Yes 0 2 0 1
L:L:A19 R:R:V28 1.7 0 No No 0 3 0 1
L:L:E20 R:R:W87 2.18 5 No Yes 0 3 0 1
L:L:E20 R:R:M123 10.83 5 No No 0 3 0 1
L:L:F22 R:R:M29 7.46 0 Yes No 0 5 0 1
L:L:F22 R:R:L32 2.44 0 Yes No 0 4 0 1
L:L:F22 R:R:I206 7.54 0 Yes Yes 0 4 0 1
L:L:V23 R:R:W87 4.9 0 No Yes 0 3 0 1
L:L:L26 R:R:W36 3.42 5 Yes Yes 0 6 0 1
L:L:L26 R:R:Y84 4.69 5 Yes Yes 0 5 0 1
L:L:L26 R:R:W115 2.28 5 Yes Yes 0 4 0 1
L:L:E27 R:R:P114 9.43 0 No No 0 5 0 1
L:L:E27 R:R:Q122 7.65 0 No No 0 3 0 1
R:R:G26 R:R:S25 1.86 0 No No 6 4 1 2
R:R:L32 R:R:P86 3.28 0 No No 4 3 1 2
R:R:W36 R:R:Y84 5.79 5 Yes Yes 6 5 1 1
R:R:W115 R:R:W36 7.5 5 Yes Yes 4 6 1 1
R:R:D209 R:R:W36 8.93 0 No Yes 4 6 2 1
R:R:W83 R:R:Y39 7.72 5 Yes No 2 6 2 2
R:R:Y39 R:R:Y84 6.95 5 No Yes 6 5 2 1
R:R:P82 R:R:Y84 9.74 5 No Yes 8 5 2 1
R:R:L85 R:R:P82 3.28 5 Yes No 6 8 2 2
R:R:W83 R:R:Y84 1.93 5 Yes Yes 2 5 2 1
R:R:L85 R:R:Y84 4.69 5 Yes Yes 6 5 2 1
R:R:W115 R:R:Y84 3.86 5 Yes Yes 4 5 1 1
R:R:L85 R:R:P86 3.28 5 Yes No 6 3 2 2
R:R:L85 R:R:W87 4.56 5 Yes Yes 6 3 2 1
R:R:L85 R:R:P114 4.93 5 Yes No 6 5 2 1
R:R:P86 R:R:W87 10.81 5 No Yes 3 3 2 1
R:R:M123 R:R:W87 11.63 5 No Yes 3 3 1 1
R:R:A118 R:R:P114 1.87 0 No No 5 5 2 1
R:R:R116 R:R:W115 5 0 No Yes 6 4 2 1
R:R:Q122 R:R:S119 2.89 0 No No 3 5 1 2
R:R:F141 R:R:M137 3.73 0 Yes No 6 4 1 2
R:R:F141 R:R:S140 2.64 0 Yes No 6 4 1 2
R:R:F141 R:R:F383 5.36 0 Yes No 6 5 1 2
R:R:Q142 R:R:Y145 7.89 9 Yes Yes 5 7 1 1
R:R:D195 R:R:Q142 10.44 9 Yes Yes 7 5 2 1
R:R:Q142 R:R:R199 2.34 9 Yes No 5 4 1 2
R:R:T146 R:R:Y145 2.5 0 No Yes 7 7 2 1
R:R:Y145 R:R:Y149 1.99 9 Yes Yes 7 8 1 1
R:R:V191 R:R:Y145 2.52 9 Yes Yes 7 7 1 1
R:R:D195 R:R:Y145 6.9 9 Yes Yes 7 7 2 1
R:R:A188 R:R:Y149 2.67 0 No Yes 8 8 2 1
R:R:V191 R:R:Y149 6.31 9 Yes Yes 7 8 1 1
R:R:S390 R:R:Y149 7.63 0 No Yes 9 8 2 1
R:R:I235 R:R:K187 7.27 0 Yes No 5 8 1 2
R:R:D195 R:R:R199 3.57 9 Yes No 7 4 2 2
R:R:L198 R:R:Y202 2.34 0 No Yes 6 1 1 1
R:R:R201 R:R:W215 26.99 14 Yes Yes 4 2 2 1
R:R:Q293 R:R:R201 10.51 14 No Yes 4 4 2 2
R:R:W215 R:R:Y202 1.93 14 Yes Yes 2 1 1 1
R:R:G207 R:R:I206 1.76 0 No Yes 1 4 2 1
R:R:L216 R:R:W215 4.56 0 No Yes 2 2 2 1
R:R:Q293 R:R:W215 4.38 14 No Yes 4 2 2 1
R:R:A228 R:R:T296 1.68 0 No No 5 5 2 1
R:R:M231 R:R:Q232 2.72 0 No Yes 6 7 2 1
R:R:I235 R:R:M231 2.92 0 Yes No 5 6 1 2
R:R:Q232 R:R:W282 7.67 21 Yes Yes 7 9 1 2
R:R:L307 R:R:Q232 2.66 21 No Yes 7 7 2 1
R:R:I235 R:R:Y239 2.42 0 Yes No 5 8 1 2
R:R:E362 R:R:Y239 10.1 0 Yes No 8 8 2 2
R:R:L307 R:R:W282 12.53 21 No Yes 7 9 2 2
R:R:C294 R:R:T296 5.07 0 No No 9 5 2 1
R:R:N298 R:R:W304 19.21 0 No Yes 6 6 1 1
R:R:L307 R:R:W304 5.69 21 No Yes 7 6 2 1
R:R:R308 R:R:W304 13 0 No Yes 6 6 2 1
R:R:D370 R:R:W304 2.23 16 Yes Yes 4 6 1 1
R:R:E371 R:R:R308 2.33 0 Yes No 5 6 2 2
R:R:D385 R:R:E362 5.2 0 No Yes 7 8 1 2
R:R:D370 R:R:E371 2.6 16 Yes Yes 4 5 1 2
R:R:D370 R:R:R378 3.57 16 Yes Yes 4 4 1 1
R:R:A373 R:R:R378 4.15 0 No Yes 3 4 2 1
R:R:L382 R:R:R378 2.43 0 No Yes 5 4 1 1
R:R:D385 R:R:K381 2.77 0 No No 7 7 1 2
L:L:S11 R:R:S297 1.63 0 No No 0 4 0 1
L:L:S16 R:R:V28 1.62 0 No No 0 3 0 1
R:R:S190 R:R:V191 1.62 0 No Yes 5 7 2 1
R:R:I206 R:R:V212 1.54 0 Yes No 4 3 1 2
R:R:I128 R:R:M123 1.46 0 No No 2 3 2 1
R:R:Q131 R:R:V130 1.43 0 No No 3 1 1 2
R:R:Q232 R:R:V279 1.43 21 Yes No 7 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.19Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
80.77Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
80.77Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
76.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
74.07Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
73.08Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
73.08Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
72.41Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
72.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
72.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
69.23Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
69.23Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
67.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
66.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
66.67Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
66.67Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
65.52Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
65.38Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
65.38Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
65.38Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
64.29Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
64.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
64.29Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
63.33Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
62.96Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
62.07Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
61.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
60.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
60.71Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
60.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
59.38Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
59.38Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
59.26Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
59.26Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
59.26Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
58.62Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
58.62Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
57.69Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
57.14Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
57.14Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
56.25Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
55.56Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
55.56Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
55.17Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
55.17Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
54.29Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
53.85Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
53.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
53.12Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
51.85Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
51.61Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
48.48Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
48.39Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
48.28Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
47.06Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
47.06Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.88Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
46.88Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
46.15Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
45.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
45.16Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
45.16Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
45.16Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
44.44Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
44.12Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
43.75Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
41.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
41.67Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.74Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
40.62Single6FJ3PTH6FJ3-PTH1-PTH
40.62Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
40.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
38.24Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
37.84Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
37.50Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
35.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
35.29Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
35.29Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
35.29Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
34.48Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
34.38Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
34.38Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
34.29Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
34.29Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
34.29Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
34.29Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
34.21Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
33.33Single4XT1Fractalkine4XT1-US28-Fractalkine
33.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
33.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
33.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
33.33Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
32.43Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
32.35Single4XT3Fractalkine4XT3-US28-Fractalkine
32.26Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
32.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
30.56Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
30.56Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
30.43Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
30.30Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
30.30Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
29.73Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
29.73Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
29.41Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
29.41Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
28.95Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
28.95Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
28.57Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
28.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
28.12Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
28.12Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
28.12Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.91Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
27.78Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
27.78Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
27.59Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
27.59Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.03Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
26.92Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
26.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
26.47Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.47Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
26.47Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
26.47Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.47Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.93Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
25.93Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.93Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.81Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.81Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
25.71Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
25.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
25.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
25.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
25.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
25.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
24.44Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
24.32Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
24.32Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.32Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.32Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
24.32Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.32Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.24Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.24Single7XNACYN1548067XNA-SST2-CYN154806
24.24Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
24.24Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
24.24Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
24.24Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
24.14Single5XR8AM8415XR8-CB1-AM841
24.14Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
24.14Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
24.00Single6LI0C176LI0-GPR52-C17
24.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
23.53Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
23.53Consensusangiotensin_onOrthosteric Ligandat1_on
23.53Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.53Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
23.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
23.33Single4XESNeurotensin4XES-NTS1-Neurotensin
23.33Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
23.33Single6OS2TRV0266OS2-AT1-TRV026
23.33Single6YVRNTS8-136YVR-NTS1-NTS8-13
23.33Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
23.33Single8JWY2-1188JWY-A2A-2-118
23.33Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
23.33Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.33Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
23.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
23.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
23.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
23.33Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
23.33Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
23.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
23.33Consensuslpa_offOrthosteric Ligandlpa1_off
23.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.08Single4BWBNeurotensin4BWB-NTS1-Neurotensin
23.08Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.08Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
23.08Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
23.08Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
22.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
22.86Single6JODAngiotensin II6JOD-AT2-Angiotensin II
22.86Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
22.86Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.86Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
22.86Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
22.86Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
22.86Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
22.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
22.58Single4BUONeurotensin4BUO-NTS1-Neurotensin
22.58Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
22.58Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
22.58Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
22.58Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.58Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
22.22Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
22.22Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
22.22Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
22.22Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
22.22Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
22.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.22Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
22.22Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
22.22Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
22.22Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
22.22Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
22.22Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single4UG2CGS216804UG2-A2A-CGS21680
21.88Single5EE7MK08935EE7-Glucagon-MK0893
21.88Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
21.88Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
21.88Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
21.88Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
21.88Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
21.88Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
21.88Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
21.88Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
21.88Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
21.74Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
21.74Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
21.43Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
21.43Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
21.43Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
21.43Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
21.43Single7V3ZCP559407V3Z-CB1-CP55940
21.43Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
21.43Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
21.43Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
21.43Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
21.43Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
21.43Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
21.43Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
21.43Single9B9ZA1AKO9B9Z-CB1-A1AKO
21.43Consensusa3_onOrthosteric Liganda3a_on
21.43Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
21.43Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
21.43Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
21.43Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
21.43Consensushca_on_gpOrthosteric Ligandhca2_on_gp
21.43Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
21.43Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
21.21Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.21Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
21.21Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.21Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
21.21Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
21.21Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
21.21Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
21.21Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
21.21Consensussomatostatin_offOrthosteric Ligandsst2_off
21.21Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.05Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
21.05Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
21.05Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
20.69Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.69Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
20.69Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
20.69Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
20.69Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
20.69Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
20.69Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.69Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
20.69Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
20.69Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
20.69Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
20.69Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
20.69Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensusa3_on_gpOrthosteric Liganda3a_on_gp
20.69Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.69Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.69Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
20.59Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
20.59Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.59Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.59Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
20.59Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.59Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.59Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.59Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
20.51Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
20.45Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.45Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
20.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
20.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
20.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
20.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
20.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
20.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
20.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
20.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
20.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
20.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
20.00Consensusa2_onOrthosteric Liganda2b_on
20.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
20.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusbombesin_onOrthosteric Ligandbb2_on
20.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
20.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
20.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.00Consensuslpa_onOrthosteric Ligandlpa1_on
20.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
20.00Consensusneurotensin_onOrthosteric Ligandnts1_on
20.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
20.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
20.00Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
19.44Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.44Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.44Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
19.44Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.44Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
19.44Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.44Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.44Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
19.44Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.44Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
19.44Consensusvasop-oxy_onOrthosteric Ligandv2_on
19.44Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
19.35Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
19.35Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
19.35Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
19.35Single6KQICP559406KQI-CB1-CP55940-Org27569
19.35Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
19.35Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
19.35Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
19.35Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
19.35Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.35Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
19.35Single8JWZAB9288JWZ-A2A-AB928-Na
19.35Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.35Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
19.35Single8XYIVUF106618XYI-CXCR3-VUF10661
19.35Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
19.35Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.35Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
19.35Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
19.35Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
19.35Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.35Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.23Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
19.23Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
19.23Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
19.23Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
19.23Single8K5BNiacin8K5B-HCA2-Niacin
19.23Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
19.23Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
19.23Single9B9Y7DY9B9Y-CB1-7DY
19.05Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.05Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
18.92Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
18.92Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
18.92Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.92Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
18.92Single8ZRTET-18ZRT-ETB-ET-1
18.92Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
18.92Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.92Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
18.75Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
18.75Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
18.75Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
18.75Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
18.75Single7EZCUKA7EZC-A2A-UKA
18.75Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
18.75Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
18.75Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
18.75Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
18.75Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
18.75Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
18.75Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
18.75Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
18.75Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
18.75Consensuscck_onOrthosteric Ligandccka_on cckb_on
18.75Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
18.75Consensuschemerin_onOrthosteric Ligandcml1_on
18.75Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
18.75Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
18.75Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
18.75Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single3PWHZM-2413853PWH-A2A-ZM-241385
18.52Single5U09Taranabant5U09-CB1-Taranabant
18.52Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
18.52Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
18.52Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
18.52Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.52Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
18.52Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
18.52Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.52Single9BA0A1AKN9BA0-CB1-A1AKN
18.52Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
18.52Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
18.52Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.52Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.52Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.42Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.42Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
18.42Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.42Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.18Single3NY9ICI118-5513NY9-β2-ICI118-551
18.18Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
18.18Single5ZTYAM102575ZTY-CB2-AM10257
18.18Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
18.18Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
18.18Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7SK9CCX6627SK9-ACKR3-CCX662
18.18Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
18.18Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
18.18Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.18Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
18.18Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
18.18Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
18.18Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
18.18Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
18.18Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
18.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.95Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.95Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
17.95Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
17.86Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.86Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
17.86Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
17.86Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
17.86Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
17.86Single7T32ZM-2413857T32-A2A-ZM-241385
17.86Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.86Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
17.86Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
17.86Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
17.86Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
17.86Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
17.86Single8K5CAcipimox8K5C-HCA2-Acipimox
17.86Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
17.86Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.86Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
17.86Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
17.86Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
17.86Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
17.86Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
17.86Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
17.86Consensushca_onOrthosteric Ligandhca2_on
17.86Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
17.86Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
17.65Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
17.65Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
17.65Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
17.65Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
17.65Single8WDTphotoNECA8WDT-A2A-photoNECA
17.65Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.65Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.65Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
17.65Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
17.65Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
17.50Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.50Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
17.50Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.50Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.50Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.50Consensusbradykinin_onOrthosteric Ligandbk2_on
17.50Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
17.50Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.50Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
17.24Single4YAYZD-71554YAY-AT1-ZD-7155
17.24Single5T04Neurotensin5T04-NTS1-Neurotensin
17.24Single5UENDU1725UEN-A1-DU172
17.24Single5UIGCmpd-15UIG-A2A-Cmpd-1
17.24Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.24Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
17.24Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
17.24Single6PS1Timolol6PS1-β2-Timolol
17.24Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
17.24Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
17.24Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
17.24Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
17.24Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
17.24Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
17.24Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
17.24Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
17.24Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
17.24Single8K5DGSK2560738K5D-HCA2-GSK256073
17.24Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
17.24Single8RLNLUF58348RLN-A2A-LUF5834
17.24Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
17.24Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.24Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
17.24Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.24Single9CHXS-Carazolol9CHX-β2-S-Carazolol
17.24Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.24Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
17.14Single3QAKUK-4320973QAK-A2A-UK-432097
17.14Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.14Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
17.14Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
17.14Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.14Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.14Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
17.14Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
17.14Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.14Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.67Single3OE0CVX153OE0-CXCR4-CVX15
16.67Single4JKVTaladegib4JKV-SMO-Taladegib
16.67Single5C1MBU725C1M-μ-BU72
16.67Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
16.67Single5WF5UK-4320975WF5-A2A-UK-432097
16.67Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
16.67Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
16.67Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
16.67Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
16.67Single6W25SHU91196W25-MC4-SHU9119-Ca
16.67Single7C4SS1P7C4S-S1P3-S1P
16.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
16.67Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
16.67Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
16.67Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
16.67Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
16.67Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
16.67Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8HS2Fab0468HS2-GPR20-Fab046
16.67Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
16.67Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
16.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
16.67Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
16.67Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
16.67Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
16.67Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
16.67Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
16.67Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
16.67Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
16.67Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
16.67Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
16.67Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
16.67Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
16.67Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
16.67Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
16.67Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
16.67Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
16.67Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
16.67Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrace-amine_onOrthosteric Ligandta1_on
16.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.22Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
16.22Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
16.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
16.22Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.22Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.22Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.13Single2YDVNECA2YDV-A2A-NECA
16.13Single3P0GBI1671073P0G-β2-BI167107
16.13Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
16.13Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
16.13Single4UHRCGS216804UHR-A2A-CGS21680
16.13Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
16.13Single5G53NECA5G53-A2A-NECA-Gs
16.13Single5V56TC1145V56-SMO-TC114
16.13Single5V57TC1145V57-SMO-TC114
16.13Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.13Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.13Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
16.13Single6OS1TRV0266OS1-AT1-TRV026
16.13Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.13Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
16.13Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
16.13Single7PX4PSB-21137PX4-A2A-PSB-2113
16.13Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
16.13Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
16.13Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.13Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
16.13Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
16.13Single8E0GBU728E0G-μ-BU72
16.13Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
16.13Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
16.13Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
16.13Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
16.13Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
16.13Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
16.13Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
16.13Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
16.13Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
16.13Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.13Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
16.13Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
16.13Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
16.13Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
16.13Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.13Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.13Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
16.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
15.91Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
15.79Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
15.79Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
15.79Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
15.79Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
15.79Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
15.79Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.62Single4N4WSANT-14N4W-SMO-SANT-1
15.62Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
15.62Single6IIURamatroban6IIU-TP-Ramatroban
15.62Single6MXTSalmeterol6MXT-β2-Salmeterol
15.62Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
15.62Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
15.62Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
15.62Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
15.62Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
15.62Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
15.62Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
15.62Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
15.62Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.62Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
15.62Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
15.62Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
15.62Single8JJ8Formoterol8JJ8-β2-Formoterol
15.62Single8JJLOlodaterol8JJL-β2-Olodaterol
15.62Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
15.62Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
15.62Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
15.62Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
15.62Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.62Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
15.62Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.62Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
15.62Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
15.62Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.62Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
15.62Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
15.62Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
15.38Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.38Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
15.38Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.38Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.38Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
15.38Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
15.38Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
15.38Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
15.38Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
15.38Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.38Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.38Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
15.15Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
15.15Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
15.15Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
15.15Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
15.15Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
15.15Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
15.15Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
15.15Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.15Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
15.15Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
15.15Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
15.15Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
15.15Single7UM4AS26747237UM4-5-HT5A-AS2674723
15.15Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
15.15Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
15.15Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
15.15Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.15Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
15.15Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
15.15Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
15.15Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
15.15Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8XVUCXCL28XVU-CXCR2-CXCL2
15.15Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
15.15Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.15Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.15Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.15Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
15.15Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
15.15Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusprostanoid_offOrthosteric Ligandep_off dp_off
15.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
15.00Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.81Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
14.81Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
14.81Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
14.81Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
14.81Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
14.81Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
14.81Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
14.81Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
14.71Single5WF6UK-4320975WF6-A2A-UK-432097
14.71Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
14.71Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.71Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
14.71Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.71Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
14.71Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
14.71Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
14.71Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
14.71Single8QJ2pN1628QJ2-MC4-pN162-Gs
14.71Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
14.71Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
14.71Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
14.63Single6IGLIRL16206IGL-ETB-IRL1620
14.63Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
14.63Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.63Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
14.29Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.29Single4IARErgotamine4IAR-5-HT1B-Ergotamine
14.29Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
14.29Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
14.29Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.29Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.29Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.29Single6AKXA4R6AKX-CCR5-A4R
14.29Single6AKYMaraviroc6AKY-CCR5-Maraviroc
14.29Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
14.29Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.29Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
14.29Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
14.29Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
14.29Single7F8XNN90567F8X-CCKA-NN9056
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7QA8Peptide7QA8-STE2-Peptide
14.29Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
14.29Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
14.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.29Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
14.29Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
14.29Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
14.29Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
14.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
14.29Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
14.29Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
14.29Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.29Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.29Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
14.29Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
14.29Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
14.29Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
14.29Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.29Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
14.29Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
14.29Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
14.29Single8IWESpermidine8IWE-TA9-Spermidine
14.29Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
14.29Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
14.29Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.29Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
14.29Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
14.29Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
14.29Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
14.29Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
14.29Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
14.29Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.29Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.29Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8XWNCXCL88XWN-CXCR2-CXCL8
14.29Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
14.29Consensusalpha2_offOrthosteric Ligandalpha2c_off
14.29Consensusangiotensin_offOrthosteric Ligandat1_off
14.29Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
14.29Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
14.29Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
14.29Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.29Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
13.95Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.95Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.89Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
13.89Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
13.89Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.89Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
13.89Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
13.89Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
13.89Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
13.89Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.89Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
13.89Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
13.89Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
13.89Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
13.79Single2YDOAdenosine2YDO-A2A-Adenosine
13.79Single3REYXAC3REY-A2A-XAC
13.79Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
13.79Single4MBSMaraviroc4MBS-CCR5-Maraviroc
13.79Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
13.79Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.79Single5IUBQ274563445IUB-A2A-Q27456344-Na
13.79Single5JTBZM-2413855JTB-A2A-ZM-241385
13.79Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
13.79Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
13.79Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
13.79Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
13.79Single6AQFZM-2413856AQF-A2A-ZM-241385
13.79Single6MH8ZM-2413856MH8-A2A-ZM-241385
13.79Single6PS0S-Carazolol6PS0-β2-S-Carazolol
13.79Single6PS4ICI118-5516PS4-β2-ICI118-551
13.79Single6PS5S-Propranolol6PS5-β2-S-Propranolol
13.79Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.79Single7AROLUF58337ARO-A2A-LUF5833-Na
13.79Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
13.79Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
13.79Single7UL3Famotidine7UL3-H2-Famotidine
13.79Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.79Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
13.79Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
13.79Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
13.79Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
13.79Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
13.79Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
13.79Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
13.79Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
13.79Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
13.79Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
13.79Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
13.79Single8K2WAMG4878K2W-CXCR3-AMG487
13.79Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
13.79Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
13.79Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
13.79Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
13.79Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
13.79Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.79Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
13.79Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
13.79Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
13.79Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
13.79Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
13.79Consensusa2_offOrthosteric Liganda2a_off
13.79Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
13.79Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
13.79Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.79Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
13.51Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.51Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.51Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
13.51Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.51Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
13.51Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
13.51Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.51Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
13.51Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.51Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.51Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
13.51Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.51Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.51Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single2Y04Salbutamol2Y04-β1-Salbutamol
13.33Single3EMLZM-2413853EML-A2A-ZM-241385
13.33Single3NY8ICI118-5513NY8-β2-ICI118-551
13.33Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
13.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.33Single4GBRS-Carazolol4GBR-β2-S-Carazolol
13.33Single4QIMANTA XV4QIM-SMO-ANTA XV
13.33Single4QKX35V4QKX-β2-35V
13.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
13.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.33Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.33Single5TGZAM65385TGZ-CB1-AM6538
13.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.33Single6D27CAY104716D27-DP2-CAY10471
13.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.33Single6H7MSalbutamol6H7M-β1-Salbutamol
13.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.33Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
13.33Single6S0LZM-2413856S0L-A2A-ZM-241385
13.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
13.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
13.33Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
13.33Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
13.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
13.33Single7PYRPSB-21157PYR-A2A-PSB-2115
13.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
13.33Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
13.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
13.33Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
13.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
13.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
13.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.33Single8CU6LJ-45178CU6-A2A-LJ-4517
13.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.33Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
13.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
13.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
13.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
13.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
13.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
13.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
13.33Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.33Single8JJOAlprenolol8JJO-β2-Alprenolol
13.33Single8JXRLSD8JXR-D1-LSD
13.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.33Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
13.33Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
13.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.33Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
13.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.33Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.33Consensusblt_onOrthosteric Ligandblt1_on
13.33Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
13.33Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.33Consensusdopamine_offOrthosteric Ligandd2_off d3_off
13.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
13.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
13.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.33Consensusleukotriene_onOrthosteric Ligandblt_on
13.33Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
13.16Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.16Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.16Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.16Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
12.90Single2RH1S-Carazolol2RH1-β2-S-Carazolol
12.90Single2Y03Isoprenaline2Y03-β1-Isoprenaline
12.90Single2YCWS-Carazolol2YCW-β1-S-Carazolol
12.90Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
12.90Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
12.90Single5D6LS-Carazolol5D6L-β2-S-Carazolol
12.90Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.90Single5JQHS-Carazolol5JQH-β2-S-Carazolol
12.90Single5N2RPSB-365N2R-A2A-PSB-36-Na
12.90Single5N2SPSB365N2S-A1-PSB36
12.90Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
12.90Single5TVNLSD5TVN-5-HT2B-LSD
12.90Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
12.90Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
12.90Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
12.90Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
12.90Single6D26Fevipiprant6D26-DP2-Fevipiprant
12.90Single6E67BI1671076E67-β2-BI167107-Gs (fused)
12.90Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
12.90Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
12.90Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
12.90Single6PS6Timolol6PS6-β2-Timolol
12.90Single6S0QZM-2413856S0Q-A2A-ZM-241385
12.90Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
12.90Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
12.90Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
12.90Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
12.90Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.90Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.90Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
12.90Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
12.90Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
12.90Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
12.90Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.90Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.90Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
12.90Single8JXSPF-61428JXS-D1-PF-6142
12.90Single8QOTNanobody-E8QOT-μ-Nanobody-E
12.90Single8S4DCMF-0198S4D-Apelin-CMF-019
12.90Single8TF5Oleic acid8TF5-GPR6-Oleic acid
12.90Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
12.90Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.90Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
12.90Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
12.90Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
12.90Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.90Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.90Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
12.90Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
12.90Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
12.90Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
12.90Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
12.90Consensusamine_offonOrthosteric Ligandamine_off amine_on
12.90Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
12.90Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
12.90Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
12.90Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
12.90Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
12.90Consensusdp_offOrthosteric Liganddp2_off
12.90Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
12.90Consensusep_offOrthosteric Ligandep4_off
12.90Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.90Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
12.90Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.90Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.90Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.90Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
12.82Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.82Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.82Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.50Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
12.50Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.50Single5D5AS-Carazolol5D5A-β2-S-Carazolol
12.50Single5D5BS-Carazolol5D5B-β2-S-Carazolol
12.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.50Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
12.50Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.50Single6J21Aprepitant6J21-NK1-Aprepitant
12.50Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.50Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.50Single6WGTLSD6WGT-5-HT2A-LSD
12.50Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.50Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.50Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
12.50Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
12.50Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
12.50Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.50Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.50Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
12.50Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.50Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.50Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
12.50Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
12.50Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.50Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
12.50Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
12.50Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
12.50Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
12.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.50Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
12.50Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
12.50Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
12.50Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
12.50Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.50Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
12.50Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.50Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.50Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.50Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.50Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.50Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
12.50Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
12.50Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.50Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.50Consensusrelaxin_onOrthosteric Ligandrxfp4_on
12.50Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
12.20Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
12.20Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
12.12Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.12Single3D4STimolol3D4S-β2-Timolol
12.12Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.12Single4AMIBucindolol4AMI-β1-Bucindolol
12.12Single4LDEBI1671074LDE-β2-BI167107
12.12Single4RWADIPP-NH24RWA-δ-DIPP-NH2
12.12Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
12.12Single6A93Risperidone6A93-5-HT2A-Risperidone
12.12Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.12Single6CM4Risperidone6CM4-D2-Risperidone
12.12Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.12Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.12Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.12Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.12Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.12Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
12.12Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.12Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
12.12Single7YITNalfurafine7YIT-κ-Nalfurafine
12.12Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.12Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
12.12Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.12Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
12.12Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
12.12Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
12.12Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
12.12Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
12.12Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
12.12Single8XQJJN2418XQJ-Apelin-JN241
12.12Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.12Single8XWMCXCL68XWM-CXCR2-CXCL6
12.12Single8XWSCXCL58XWS-CXCR2-CXCL5
12.12Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
12.12Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.12Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.12Consensusalpha1_offOrthosteric Ligandalpha1a_off
12.12Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
12.12Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
12.12Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
12.12Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.12Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
12.12Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.12Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.12Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.12Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.12Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.12Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.12Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.12Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
12.12Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.00Single8PWNTheophylline8PWN-A2A-Theophylline
12.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.90Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
11.76Single6H7LDobutamine6H7L-β1-Dobutamine
11.76Single6IBLArformoterol6IBL-β1-Arformoterol
11.76Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
11.76Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.76Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
11.76Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
11.76Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
11.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.76Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
11.76Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
11.76Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.76Single8XWFCXCL38XWF-CXCR2-CXCL3
11.76Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
11.76Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.76Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.76Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
11.76Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
11.63Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
11.63Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
11.54Single3RFMCaffeine3RFM-A2A-Caffeine
11.54Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.54Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
11.54Single9CHUNoradrenaline9CHU-β2-Noradrenaline
11.54Consensusp2y_offOrthosteric Ligandp2y1_off
11.43Single6KNMJN241-96KNM-Apelin-JN241-9
11.43Single6PT3DPI-2876PT3-δ-DPI-287
11.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
11.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
11.43Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
11.43Single7XN9L-054,5227XN9-SST2-L-054,522
11.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
11.43Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
11.43Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.43Single8XQJJN2418XQJ-Apelin-JN241
11.43Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
11.43Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.43Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
11.43Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
11.43Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.36Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
11.11Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.11Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.11Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.11Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
11.11Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.11Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.11Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
11.11Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.11Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
11.11Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8WKYPG-9348WKY-MC4-PG-934
11.11Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.11Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.11Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.11Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
11.11Consensus5ht2_onOrthosteric Ligand5ht2b_on
11.11Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.11Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.81Single6HLOAprepitant6HLO-NK1-Aprepitant
10.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
10.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
10.81Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
10.81Single7SK5CXCL127SK5-ACKR3-CXCL12
10.81Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
10.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
10.71Single3OE9IT1t3OE9-CXCR4-IT1t
10.71Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.71Single5L7IVismodegib5L7I-SMO-Vismodegib
10.71Single7SRQLSD7SRQ-5-HT2B-LSD
10.71Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.71Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.71Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.71Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.71Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
10.71Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
10.71Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
10.71Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
10.71Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
10.71Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.71Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.71Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
10.71Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.71Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.71Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
10.71Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.71Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
10.71Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
10.71Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
10.71Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.71Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
10.71Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.71Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.71Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
10.53Single6PT2KGCHM076PT2-δ-KGCHM07
10.53Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.34Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.34Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.34Single4QINSAG1.54QIN-SMO-SAG1.5
10.34Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.34Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.34Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.34Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.34Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.34Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.34Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.34Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.34Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
10.34Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
10.34Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
10.34Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.34Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.34Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.34Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.34Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
10.34Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.34Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.34Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
10.34Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.34Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.34Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
10.34Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.34Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.34Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.34Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
10.34Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
10.34Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.34Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
10.34Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
10.34Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.34Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.34Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.34Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.34Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.34Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.34Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.34Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.26Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
10.26Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
10.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
10.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.00Single5UVIZM-2413855UVI-A2A-ZM-241385
10.00Single6A94Zotepine6A94-5-HT2A-Zotepine
10.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
10.00Single6KUXRS-799486KUX-α2a-RS-79948
10.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single6VI4JDTic6VI4-κ-JDTic
10.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
10.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
10.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
10.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
10.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
10.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
10.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
10.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
10.00Single8IHKAcifran8IHK-HCA3-Acifran
10.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
10.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
10.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
10.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
10.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
10.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
10.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
10.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
10.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
10.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
10.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
9.76Single7SK3CXCL127SK3-ACKR3-CXCL12
9.68Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
9.68Single2Y01Dobutamine2Y01-β1-Dobutamine
9.68Single2Y02Carmoterol2Y02-β1-Carmoterol
9.68Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
9.68Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
9.68Single4DAJTiotropium4DAJ-M3-Tiotropium
9.68Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
9.68Single4EJ4Naltrindole4EJ4-δ-Naltrindole
9.68Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
9.68Single4MQSIperoxo4MQS-M2-Iperoxo
9.68Single4U14Tiotropium4U14-M3-Tiotropium
9.68Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
9.68Single5DHHSB-6121115DHH-NOP-SB-612111
9.68Single5DSGTiotropium5DSG-M4-Tiotropium
9.68Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
9.68Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
9.68Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
9.68Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
9.68Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
9.68Single6DRXLisuride6DRX-5-HT2B-Lisuride
9.68Single6GPSMK08126GPS-CCR2-MK0812
9.68Single6IIVDaltroban6IIV-TP-Daltroban
9.68Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.68Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
9.68Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
9.68Single7BU7BI1671077BU7-β1-BI167107
9.68Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
9.68Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.68Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
9.68Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
9.68Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
9.68Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.68Single7UL4Alvimopan7UL4-μ-Alvimopan
9.68Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
9.68Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.68Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
9.68Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.68Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
9.68Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.68Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
9.68Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
9.68Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
9.68Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
9.68Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
9.68Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
9.68Single8T1WCVN4248T1W-GPR6-CVN424
9.68Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.68Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
9.68Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
9.68Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
9.68Single8X63Mepyramine8X63-H1-Mepyramine
9.68Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
9.68Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
9.68Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
9.68Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
9.68Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
9.68Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
9.68Single9IYAONO-97105319IYA-GPR55-ONO-9710531
9.68Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.68Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.68Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
9.68Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
9.68Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.68Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
9.68Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
9.68Consensusalpha2_onOrthosteric Ligandalpha2b_on
9.68Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
9.68Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.68Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.68Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
9.68Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
9.68Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
9.68Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.68Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
9.68Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
9.68Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.68Consensushistamine_offOrthosteric Ligandh1_off
9.68Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
9.68Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
9.68Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
9.68Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.38Single2Y00Dobutamine2Y00-β1-Dobutamine
9.38Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.38Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.38Single5WIUNemonapride5WIU-D4-Nemonapride
9.38Single5WIVNemonapride5WIV-D4-Nemonapride-Na
9.38Single6GPXMK08126GPX-CCR2-MK0812
9.38Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.38Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.38Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.38Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.38Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.38Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.38Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.38Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
9.38Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
9.38Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.38Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.38Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.38Single7W41PD1762527W41-BB2-PD176252
9.38Single7WC6LSD7WC6-5-HT2A-LSD
9.38Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
9.38Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
9.38Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.38Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
9.38Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
9.38Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.38Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
9.38Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
9.38Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.38Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.38Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
9.38Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.38Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.38Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.38Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.38Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
9.38Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.38Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
9.38Consensusblt_offOrthosteric Ligandblt1_off
9.38Consensusbombesin_offOrthosteric Ligandbb2_off
9.38Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
9.38Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.38Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.38Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.38Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.38Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.38Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.09Single4DJHJDTic4DJH-κ-JDTic
9.09Single4U15Tiotropium4U15-M3-Tiotropium
9.09Single5TZRMK86665TZR-FFA1-MK8666
9.09Single5V54Methiothepin5V54-5-HT1B-Methiothepin
9.09Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
9.09Single6J20Aprepitant6J20-NK1-Aprepitant
9.09Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
9.09Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Single6OL9Tiotropium6OL9-M5-Tiotropium
9.09Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
9.09Single6TQ7SB-3348676TQ7-OX1-SB-334867
9.09Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
9.09Single7P2L4YI7P2L-mGlu5-4YI
9.09Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
9.09Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.09Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
9.09Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
9.09Single8EA0Iperoxo8EA0-M3-Iperoxo
9.09Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.09Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
9.09Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.09Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.09Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.09Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
9.09Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
9.09Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
9.09Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.09Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.09Consensus5ht1_offOrthosteric Ligand5ht1b_off
9.09Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.09Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
9.09Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
9.09Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.09Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
9.09Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
9.09Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.09Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
9.09Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
8.82Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
8.82Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.82Single5CXVTiotropium5CXV-M1-Tiotropium
8.82Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
8.82Single6ZG4HTL00099366ZG4-M1-HTL0009936
8.82Single7DFPSpiperone7DFP-D2-Spiperone
8.82Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
8.82Single7K15MKD0467K15-BLT1-MKD046-Na
8.82Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
8.82Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.82Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
8.82Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
8.82Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
8.82Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.82Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
8.82Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.82Single8XWACXCL18XWA-CXCR2-CXCL1
8.82Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
8.82Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
8.82Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
8.82Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
8.82Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
8.82Consensusorexin_onOrthosteric Ligandox2_on
8.57Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.57Single5X93K-87945X93-ETB-K-8794
8.57Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
8.57Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.57Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.57Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
8.57Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
8.57Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.57Single8XVJMacitentan8XVJ-ETA-Macitentan
8.57Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
8.57Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
8.57Consensusendothelin_offOrthosteric Ligandetb_off
8.57Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
8.57Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
8.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.33Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
8.33Single8X5YAstemizole8X5Y-H1-Astemizole
8.33Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.11Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.11Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
8.11Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.11Single8IEBA1LYA8IEB-GPR156-A1LYA
8.11Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.11Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.11Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.11Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.11Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.11Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.89Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
7.69Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.50Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
7.50Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
7.50Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.41Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
7.41Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
7.41Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
7.41Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.41Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.14Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.14Single3OE6IT1t3OE6-CXCR4-IT1t
7.14Single3UZAGTPL92363UZA-A2A-GTPL9236
7.14Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.14Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.14Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.14Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
7.14Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.14Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.14Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.14Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.14Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
7.14Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
7.14Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
7.14Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.14Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.14Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.90Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
6.90Single3PBLEticlopride3PBL-D3-Eticlopride
6.90Single6HLLCP999946HLL-NK1-CP99994
6.90Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.90Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.90Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.90Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Single7UL2SR486927UL2-NTS1-SR48692-Na
6.90Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.90Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
6.90Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.90Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.90Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
6.90Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
6.90Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.90Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
6.90Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
6.90Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
6.90Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
6.90Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.90Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.90Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Consensusneurotensin_offOrthosteric Ligandnts1_off
6.90Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.67Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
6.67Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
6.67Single3ODUIT1t3ODU-CXCR4-IT1t
6.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.67Single6B73MP11046B73-κ-MP1104
6.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67Single6TODEMPA6TOD-OX1-EMPA-Na
6.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
6.67Single7F8ULintitript7F8U-CCKA-Lintitript
6.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
6.67Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
6.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
6.67Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.67Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
6.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.67Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
6.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
6.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
6.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
6.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
6.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
6.45Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.45Single3RZECidoxepin3RZE-H1-Cidoxepin
6.45Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.45Single4ZJCSB-6740424ZJC-OX1-SB-674042
6.45Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.45Single6TPGEMPA6TPG-OX2-EMPA
6.45Single6TPNHTL66416TPN-OX2-HTL6641
6.45Single6V9SGTPL114036V9S-OX1-GTPL11403
6.45Single6ZG9GSK10347026ZG9-M1-GSK1034702
6.45Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.45Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.45Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.45Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
6.45Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
6.45Single7VV6C48/807VV6-MRGPRX2-C48/80
6.45Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
6.45Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
6.45Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.45Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.45Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.45Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.45Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.45Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
6.45Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
6.45Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
6.45Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
6.45Consensusgrh_offOrthosteric Ligandgnrh1_off
6.45Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
6.45Consensusopsins_offOrthosteric Ligandrhodopsin_off
6.45Consensussensory_offOrthosteric Ligandopsins_off
6.25Single5DHGC-355DHG-NOP-C-35
6.25Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
6.25Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
6.25Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.25Single6TOTLemborexant6TOT-OX1-Lemborexant
6.25Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
6.25Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
6.25Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
6.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.25Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.25Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.25Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
6.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
6.25Single8X64Desloratadine8X64-H1-Desloratadine
6.25Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.25Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
6.25Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.06Single4NTJAZD12834NTJ-P2Y12-AZD1283
6.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
6.06Single5CGCHTL142425CGC-mGlu5-HTL14242
6.06Single5WQCEMPA5WQC-OX2-EMPA
6.06Single5XPRBosentan5XPR-ETB-Bosentan
6.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
6.06Single6TP6Filorexant6TP6-OX1-Filorexant
6.06Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
6.06Single6Z4SSR486926Z4S-NTS1-SR48692
6.06Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.06Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
6.06Single7SINNPS-21437SIN-CaS-NPS-2143
6.06Single7SINNPS-21437SIN-CaS-NPS-2143
6.06Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
6.06Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.06Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
6.06Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.06Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.06Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single6E59L-7607356E59-NK1-L-760735
5.88Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
5.88Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.88Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
5.88Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.88Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
5.88Single8XVLZibotentan8XVL-ETA-Zibotentan
5.88Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88Single9BJKNAM9BJK-μ-Naloxone-NAM
5.88Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Consensustachykinin_offOrthosteric Ligandnk1_off
5.71Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.71Single5X33BIIL2605X33-BLT1-BIIL260
5.71Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.71Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.71Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
5.71Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.71Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.71Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.71Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.56Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
5.56Single5CGDHTL142425CGD-mGlu5-HTL14242
5.56Single6K1QIRL25006K1Q-ETB-IRL2500
5.56Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.56Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.56Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.41Single8IEIA1LYA8IEI-GPR156-A1LYA
5.26Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.26Single8IEIA1LYA8IEI-GPR156-A1LYA
5.26Single8IEPA1LYA8IEP-GPR156-A1LYA
5.26Single8IEPA1LYA8IEP-GPR156-A1LYA
5.13Single7SHEPI; PE7SHE-GPR158-PI; PE
5.13Single8IEBA1LYA8IEB-GPR156-A1LYA
4.88Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single6D35Cholesterol6D35-SMO-Cholesterol
4.35Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.35Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.35Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.35Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.35Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.35Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.35Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.35Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.35Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.35Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.35Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.35Single7DTTCa7DTT-CaS-Ca-Ca
4.35Single7DTTCa7DTT-CaS-Ca-Ca
4.35Single7DTUTryptophan7DTU-CaS-Tryptophan
4.35Single7DTUTryptophan7DTU-CaS-Tryptophan
4.35Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.35Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.35Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.35Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.35Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.35Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.35Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.35Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.35Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.35Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.35Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.35Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.35Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.35Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.35Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.35Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.35Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.35Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.35Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.35Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.35Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.35Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.35Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.35Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.35Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.35Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.35Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.35Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.35Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.35Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.35Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.35Single7XW7K1-707XW7-TSH-K1-70
4.35Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.35Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.35Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.35Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.35Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.35Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.35Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.35Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.35Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.35Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.35Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.35Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.35Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.35Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.35Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.35Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.35Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.35Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.35Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.35Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.35Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.35Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.35Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.35Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.35Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.35Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.35Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.35Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.35Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.35Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.35Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.35Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.35Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.35Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.35Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.35Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.35Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.35Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.35Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.35Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.35Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.35Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.35Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.35Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8WVXNorrin8WVX-LGR4-Norrin
4.35Single8WVYNorrin8WVY-LGR4-Norrin
4.35Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.35Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.35Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.35Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.35Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.35Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.35Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.35Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.35Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.17Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.17Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.00Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.00Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
3.85Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.85Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.85Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.85Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.85Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.85Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.70Single5L7DCholesterol5L7D-SMO-Cholesterol
3.70Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.70Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.70Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.70Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.57Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
3.57Single3OE8IT1t3OE8-CXCR4-IT1t
3.57Single6TQ9SB-4081246TQ9-OX1-SB-408124
3.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
3.57Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.57Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.57Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
3.57Consensussensory_onOrthosteric Ligandopsins_on
3.45Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.45Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
3.45Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
3.45Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.45Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
3.45Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.45Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.45Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.45Single8JPSCCL78JPS-ACKR1-CCL7
3.45Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.45Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.45Consensusgi_sensoryOrthosteric Ligandgi_opsins
3.45Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.45Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.45Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
3.45Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.45Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
3.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.33Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
3.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
3.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
3.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.33Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.33Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
3.23Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.23Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.23Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.23Single4S0VSuvorexant4S0V-OX2-Suvorexant
3.23Single4XNVBPTU4XNV-P2Y1-BPTU
3.23Single5WS3EMPA5WS3-OX2-EMPA
3.23Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
3.23Single6TPJSuvorexant6TPJ-OX2-Suvorexant
3.23Single7F8YDevazepide7F8Y-CCKA-Devazepide
3.23Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.23Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.23Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.23Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.23Single7XRRLemborexant7XRR-OX2-Lemborexant
3.23Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.23Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.23Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.23Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
3.23Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.23Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.23Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.23Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
3.23Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.12Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.12Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.12Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
3.12Single6IQLL7458706IQL-D4-L745870
3.12Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
3.12Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
3.12Single6TP3Nemorexant6TP3-OX1-Nemorexant
3.12Single6TPKRetosiban6TPK-OT-Retosiban
3.12Single6ZINSR486926ZIN-NTS1-SR48692
3.12Single7VODCariprazine7VOD-5-HT2A-Cariprazine
3.12Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.12Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.12Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.12Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single8IYXYL-3658IYX-GPR34-YL-365
3.12Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.12Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.12Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.12Consensusvasop-oxy_offOrthosteric Ligandot_off
3.03Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.03Single6FFHFenobam6FFH-mGlu5-Fenobam
3.03Single7F83PF-051904577F83-Ghrelin-PF-05190457
3.03Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.03Consensuscck_offOrthosteric Ligandccka_off
3.03Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
2.94Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
2.94Single6HLPNetupitant6HLP-NK1-Netupitant
2.94Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
2.94Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.94Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.86Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
2.86Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
2.78Single7SHEPI; PE7SHE-GPR158-PI; PE
2.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.56Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.56Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.50Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.44Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.44Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.38Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.22Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 8FU6
Class B1
SubFamily Peptide
Type Glucagon
SubType Glucagon
Species Homo Sapiens
Ligand Glucagon derivative ZP3780
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.9
Date 2023-04-12 
D.O.I. 10.1016/j.cell.2023.02.028
Net Summary
Imin 1.68
Number of Linked Nodes 908
Number of Links 1137
Number of Hubs 198
Number of Links mediated by Hubs 700
Number of Communities 27
Number of Nodes involved in Communities 283
Number of Links involved in Communities 404
Path Summary
Number Of Nodes in MetaPath 86
Number Of Links MetaPath 85
Number of Shortest Paths 1133540
Length Of Smallest Path 3
Average Path Length 29.9322
Length of Longest Path 58
Minimum Path Strength 1.13
Average Path Strength 4.56575
Maximum Path Strength 20.99
Minimum Path Correlation 0.7
Average Path Correlation 0.983397
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 49.6389
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.2234
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • enzyme regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • GDP binding   • purine ribonucleotide binding   • ion binding   • anion binding   • molecular function regulator activity   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • purine ribonucleoside triphosphate binding   • guanyl-nucleotide exchange factor activity   • nucleoside phosphate binding   • purine nucleotide binding   • small molecule binding   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • blood circulation   • regulation of biosynthetic process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • hormone-mediated signaling pathway   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • carbohydrate metabolic process   • energy derivation by oxidation of organic compounds   • glycogen metabolic process   • primary metabolic process   • regulation of generation of precursor metabolites and energy   • generation of precursor metabolites and energy   • regulation of polysaccharide metabolic process   • regulation of primary metabolic process   • glucan metabolic process   • polysaccharide metabolic process   • energy reserve metabolic process   • regulation of glycogen metabolic process   • regulation of carbohydrate metabolic process   • cellular response to nutrient levels   • response to nutrient levels   • cellular response to stress   • response to stress   • response to starvation   • cellular response to starvation   • cell surface receptor signaling pathway   • response to nutrient   • localization   • secretion by cell   • exocytosis   • transport   • secretion   • export from cell   • establishment of localization   • vesicle-mediated transport   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • endosome   • intracellular vesicle   • cytoplasmic vesicle
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8FU6_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGATSGIF 
ETKFQVDKV NFHMFDVGG QRDERRKWI QCFNDVTAI IFVVASSNQ 
TNRLQEALN LFKSIWNNR WLRTISVIL FLNKQDLLI EDYFPEFAR 
YTTPEDATP EPGEDPRVT RAKYFIRDE FLRISTASG DGRHYCYPH 
FTCAVDTEN IRRVFNDCR DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8FU6_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8FU6_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP47871
Sequence
>8FU6_Chain_R
PSGQVMDFL FEKWKLYGD QCHHCPWYL PWHHKVQHR FVFKRCPWR 
DASQCQMDG EEIEVQKEV AKMYSSFQV MYTVGYSLS LGALLLALA 
ILGGLSKLH CTRNAIHAN LFASFVLKA SSVLVIDGL LRTRYSQKI 
GDDLSVSTW LSDGAVAGC RVAAVFMQY GIVANYCWL LVEGLYLHN 
LLGLATLPE RSFFSLYLG IGWGAPMLF VVPWAVVKC LFENVQCWT 
SNDNMGFWW ILRFPVFLA ILINFFIFV RIVQLLVAK LRARYKFRL 
AKSTLTLIP LLGVHEVVF AFVTDEHAQ GTLRSAKLF FDLFLSSFQ 
GLLVAVLYC FLNKEVQSE LRRRWHRWR LGKV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-1310.1016/j.apsb.2024.09.002
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ223.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-0610.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-0610.1038/s41421-024-00649-0
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-0610.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-0610.1038/s41421-024-00649-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-0810.1073/pnas.2303696120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-1810.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-1810.1073/pnas.2306145120
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-1810.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-1810.1073/pnas.2306145120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-0610.1073/pnas.2303696120
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-0610.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-0610.1073/pnas.2303696120
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-1610.1038/s41586-023-06420-x
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-1610.1038/s41586-023-06420-x
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ22.92023-04-1210.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-2.92023-04-1210.1016/j.cell.2023.02.028
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-2610.1021/jacs.4c12808
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-1310.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-1310.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-1310.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-1310.1073/pnas.2303696120
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 163183774chim(NtGi1-Gs)/β1/γ23.082022-04-1310.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatidePubChem 1631837743.082022-04-1310.1073/pnas.2116506119
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-1310.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-1310.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-1310.1073/pnas.2116506119
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-0610.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-0610.1073/pnas.2106606118
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-0610.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-0210.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-0210.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-0210.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-0210.1038/s41467-022-28683-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-2310.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-2310.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-0510.1038/s41589-021-00945-w
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-2010.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-2010.1073/pnas.2106606118
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-1110.1038/s41467-021-24058-z
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-0410.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-0410.7554/eLife.68719
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-2010.1016/j.str.2021.04.008
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-1610.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-1610.1038/s41422-020-00442-0
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-1810.1073/pnas.2014879117
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-1810.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-1810.1038/s41467-020-18945-0
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-0410.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-0410.1016/j.bbrc.2020.08.042
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-2610.1038/s41422-020-0384-8
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ23.12020-08-1210.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-3.12020-08-1210.1126/science.aba3373
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-1210.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-1210.1038/s41467-020-17791-4
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-1210.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-1210.1038/s41467-020-17791-4
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-2210.1038/s41589-020-0589-7
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-2710.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-2710.1074/jbc.RA120.013793
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-0110.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-0110.1126/science.aaz5346
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-0110.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-0110.1126/science.aaz5346
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-2110.1038/nature25773
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-1710.1038/nature25153
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-2410.1038/nature22363
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-2410.1038/nature22363
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-2010.1038/nature17414
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-2410.1038/nature12393




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8FU6.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.