psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?7	H:H:?8	39.85	Yes	No	2	0	0
2	H:H:?7	R:R:Y39	5.24	Yes	Yes	2	0	6
3	H:H:?7	R:R:Q42	15.47	Yes	No	2	0	5
4	H:H:?7	R:R:N46	24.56	Yes	No	0	0	5
5	H:H:?7	R:R:C67	2.84	Yes	No	2	0	9
6	H:H:?7	R:R:W83	2.04	Yes	Yes	2	0	2
7	H:H:?8	R:R:W83	3.06	No	Yes	2	0	2
8	H:H:?10	H:H:?9	30.99	No	Yes	0	0	0
9	H:H:?9	R:R:P53	2.94	Yes	Yes	0	0	3
10	H:H:?9	R:R:N59	31.93	Yes	No	0	0	4
11	H:H:?9	R:R:Q105	7.14	Yes	No	0	0	5
12	H:H:?10	H:H:?11	26.57	No	No	0	0	0
13	H:H:?12	H:H:?13	35.42	No	No	0	0	0
14	H:H:?12	R:R:N78	24.56	No	No	8	0	4
15	H:H:?12	R:R:F97	5.45	No	Yes	8	0	5
16	H:H:?14	R:R:A73	4.23	No	No	0	0	6
17	H:H:?14	R:R:N74	23.33	No	No	0	0	7
18	R:R:A25	R:R:G24	1.95	No	No	0	4	5
19	R:R:A25	R:R:P26	1.87	No	No	0	4	6
20	R:R:A25	R:R:D30	1.54	No	No	0	4	5
21	R:R:D30	R:R:Q27	2.61	No	No	0	5	5
22	R:R:V28	R:R:Y202	8.83	No	Yes	0	3	1
23	R:R:M29	R:R:Y202	5.99	No	Yes	0	5	1
24	R:R:M29	R:R:Q204	8.16	No	No	0	5	4
25	R:R:L32	R:R:P86	3.28	No	Yes	2	4	3
26	R:R:L32	R:R:Y202	9.38	No	Yes	2	4	1
27	R:R:F33	R:R:W36	4.01	No	Yes	0	4	6
28	R:R:F62	R:R:W36	4.01	Yes	Yes	0	7	6
29	R:R:K64	R:R:W36	2.32	No	Yes	0	4	6
30	R:R:W36	R:R:Y84	10.61	Yes	Yes	0	6	5
31	R:R:D41	R:R:K37	2.77	No	No	0	4	3
32	R:R:L38	R:R:W83	2.28	No	Yes	0	3	2
33	R:R:F62	R:R:Y39	4.13	Yes	Yes	2	7	6
34	R:R:S66	R:R:Y39	2.54	Yes	Yes	2	5	6
35	R:R:P82	R:R:Y39	5.56	Yes	Yes	2	8	6
36	R:R:W83	R:R:Y39	13.5	Yes	Yes	2	2	6
37	R:R:Y39	R:R:Y84	9.93	Yes	Yes	2	6	5
38	R:R:C43	R:R:G40	1.96	Yes	No	2	9	4
39	R:R:F62	R:R:G40	6.02	Yes	No	2	7	4
40	R:R:Q42	R:R:W83	5.48	No	Yes	2	5	2
41	R:R:C43	R:R:L47	3.17	Yes	No	2	9	5
42	R:R:C43	R:R:F62	5.59	Yes	Yes	2	9	7
43	R:R:C43	R:R:C67	7.28	Yes	No	2	9	9
44	R:R:F62	R:R:H44	4.53	Yes	No	0	7	2
45	R:R:L47	R:R:R60	10.93	No	No	0	5	4
46	R:R:C67	R:R:L47	4.76	No	No	2	9	5
47	R:R:L50	R:R:P51	4.93	No	No	0	3	2
48	R:R:L50	R:R:R60	2.43	No	No	0	3	4
49	R:R:P51	R:R:P52	1.95	No	No	0	2	1
50	R:R:P52	R:R:P53	1.95	No	Yes	0	1	3
51	R:R:P53	R:R:V57	1.77	Yes	Yes	7	3	3
52	R:R:D70	R:R:P53	3.22	No	Yes	7	4	3
53	R:R:G104	R:R:L56	1.71	No	No	0	9	2
54	R:R:D70	R:R:V57	4.38	No	Yes	7	4	3
55	R:R:P72	R:R:V57	1.77	No	Yes	0	1	3
56	R:R:C58	R:R:T71	1.69	No	Yes	2	9	7
57	R:R:C100	R:R:C58	7.28	No	No	2	9	9
58	R:R:C58	R:R:W106	16.98	No	Yes	2	9	9
59	R:R:D70	R:R:R60	14.29	No	No	0	4	4
60	R:R:T61	R:R:W106	3.64	No	Yes	0	6	9
61	R:R:D63	R:R:W68	7.82	Yes	Yes	2	9	9
62	R:R:D63	R:R:K98	11.06	Yes	Yes	2	9	8
63	R:R:D63	R:R:P114	3.22	Yes	Yes	2	9	5
64	R:R:D63	R:R:R116	14.29	Yes	Yes	2	9	6
65	R:R:S66	R:R:Y65	6.36	Yes	Yes	2	5	6
66	R:R:P82	R:R:Y65	11.13	Yes	Yes	2	8	6
67	R:R:Y65	R:R:Y84	3.97	Yes	Yes	2	6	5
68	R:R:L85	R:R:Y65	2.34	Yes	Yes	2	6	6
69	R:R:V96	R:R:Y65	3.79	Yes	Yes	2	7	6
70	R:R:R116	R:R:Y65	12.35	Yes	Yes	2	6	6
71	R:R:A118	R:R:Y65	4	No	Yes	2	5	6
72	R:R:C121	R:R:Y65	4.03	Yes	Yes	2	9	6
73	R:R:S66	R:R:W68	4.94	Yes	Yes	2	5	9
74	R:R:I79	R:R:S66	3.1	No	Yes	2	4	5
75	R:R:P82	R:R:S66	5.34	Yes	Yes	2	8	5
76	R:R:S66	R:R:V96	3.23	Yes	Yes	2	5	7
77	R:R:P69	R:R:W68	2.7	No	Yes	0	6	9
78	R:R:A77	R:R:W68	2.59	No	Yes	2	7	9
79	R:R:I79	R:R:W68	8.22	No	Yes	2	4	9
80	R:R:V96	R:R:W68	3.68	Yes	Yes	2	7	9
81	R:R:K98	R:R:W68	12.76	Yes	Yes	2	8	9
82	R:R:P72	R:R:T71	5.25	No	Yes	0	1	7
83	R:R:A77	R:R:T71	5.03	No	Yes	2	7	7
84	R:R:C100	R:R:T71	1.69	No	Yes	2	9	7
85	R:R:T71	R:R:W106	8.49	Yes	Yes	2	7	9
86	R:R:P72	R:R:T75	5.25	No	No	0	1	5
87	R:R:N74	R:R:R99	2.41	No	No	0	7	3
88	R:R:N74	R:R:P102	9.77	No	No	0	7	1
89	R:R:F97	R:R:T76	2.59	Yes	No	0	5	5
90	R:R:R99	R:R:T76	9.06	No	No	0	3	5
91	R:R:A77	R:R:W106	2.59	No	Yes	2	7	9
92	R:R:F97	R:R:N78	8.46	Yes	No	8	5	4
93	R:R:I79	R:R:V96	1.54	No	Yes	2	4	7
94	R:R:F95	R:R:S80	5.28	No	No	0	1	3
95	R:R:C81	R:R:P82	1.88	No	Yes	2	9	8
96	R:R:C81	R:R:V91	5.12	No	No	0	9	6
97	R:R:C121	R:R:C81	7.28	Yes	No	2	9	9
98	R:R:P82	R:R:Y84	9.74	Yes	Yes	2	8	5
99	R:R:L85	R:R:P82	4.93	Yes	Yes	2	6	8
100	R:R:C121	R:R:P82	1.88	Yes	Yes	2	9	8
101	R:R:W83	R:R:Y84	1.93	Yes	Yes	2	2	5
102	R:R:H88	R:R:W83	2.12	No	Yes	2	4	2
103	R:R:L85	R:R:Y84	3.52	Yes	Yes	2	6	5
104	R:R:L85	R:R:P86	3.28	Yes	Yes	2	6	3
105	R:R:L85	R:R:W87	9.11	Yes	Yes	2	6	3
106	R:R:C121	R:R:L85	1.59	Yes	Yes	2	9	6
107	R:R:P86	R:R:W87	14.86	Yes	Yes	2	3	3
108	R:R:P86	R:R:Y202	11.13	Yes	Yes	2	3	1
109	R:R:P86	R:R:W215	2.7	Yes	Yes	2	3	2
110	R:R:V91	R:R:W87	2.45	No	Yes	0	6	3
111	R:R:M123	R:R:W87	11.63	Yes	Yes	2	3	3
112	R:R:W215	R:R:W87	12.18	Yes	Yes	2	2	3
113	R:R:H88	R:R:H89	11.94	No	No	2	4	5
114	R:R:H88	R:R:Q92	4.95	No	No	2	4	1
115	R:R:H89	R:R:Q92	8.65	No	No	2	5	1
116	R:R:D218	R:R:K90	5.53	No	No	0	4	4
117	R:R:R94	R:R:V91	3.92	No	No	0	5	6
118	R:R:H93	R:R:R94	7.9	No	No	0	4	5
119	R:R:Q120	R:R:R94	24.53	No	No	0	5	5
120	R:R:R116	R:R:V96	3.92	Yes	Yes	2	6	7
121	R:R:A118	R:R:V96	1.7	No	Yes	2	5	7
122	R:R:C121	R:R:V96	1.71	Yes	Yes	2	9	7
123	R:R:D117	R:R:F97	4.78	No	Yes	0	7	5
124	R:R:F97	R:R:Q120	3.51	Yes	No	0	5	5
125	R:R:K98	R:R:W106	17.4	Yes	Yes	2	8	9
126	R:R:K98	R:R:P114	1.67	Yes	Yes	2	8	5
127	R:R:K98	R:R:R116	2.48	Yes	Yes	2	8	6
128	R:R:R99	R:R:V107	5.23	No	No	0	3	5
129	R:R:C100	R:R:W106	2.61	No	Yes	2	9	9
130	R:R:G101	R:R:P102	4.06	No	No	0	5	1
131	R:R:G101	R:R:V107	1.84	No	No	0	5	5
132	R:R:D103	R:R:P102	1.61	No	No	0	5	1
133	R:R:G109	R:R:R108	1.5	Yes	No	0	4	1
134	R:R:G112	R:R:R108	4.5	No	No	0	6	1
135	R:R:G109	R:R:P110	4.06	Yes	No	2	4	3
136	R:R:G109	R:R:Q113	4.93	Yes	Yes	2	4	4
137	R:R:P110	R:R:Q113	6.32	No	Yes	2	3	4
138	R:R:Q113	R:R:R111	3.5	Yes	No	0	4	4
139	R:R:G112	R:R:Q113	1.64	No	Yes	0	6	4
140	R:R:P114	R:R:Q113	3.16	Yes	Yes	2	5	4
141	R:R:P114	R:R:R116	2.88	Yes	Yes	2	5	6
142	R:R:D117	R:R:S119	5.89	No	No	0	7	5
143	R:R:A118	R:R:Q122	1.52	No	No	0	5	3
144	R:R:G125	R:R:M123	3.49	No	Yes	2	2	3
145	R:R:M123	R:R:S213	3.07	Yes	No	0	3	3
146	R:R:M123	R:R:T214	1.51	Yes	Yes	2	3	1
147	R:R:D124	R:R:W215	2.23	No	Yes	0	2	2
148	R:R:G125	R:R:T214	1.82	No	Yes	2	2	1
149	R:R:E127	R:R:Q204	7.65	No	No	0	1	4
150	R:R:E127	R:R:S211	8.62	No	No	0	1	4
151	R:R:E127	R:R:S213	4.31	No	No	0	1	3
152	R:R:I128	R:R:T214	3.04	No	Yes	0	2	1
153	R:R:E129	R:R:I206	5.47	No	No	9	1	4
154	R:R:D209	R:R:E129	16.89	No	No	0	4	1
155	R:R:E129	R:R:S211	4.31	No	No	9	1	4
156	R:R:V130	R:R:V134	3.21	No	No	0	1	2
157	R:R:A135	R:R:V130	3.39	No	No	0	3	1
158	R:R:Q131	R:R:V134	5.73	No	No	0	3	2
159	R:R:D209	R:R:Q131	7.83	No	No	0	4	3
160	R:R:K132	R:R:K205	7.18	No	No	0	2	4
161	R:R:A135	R:R:L210	3.15	No	Yes	0	3	4
162	R:R:F141	R:R:M137	7.46	No	No	0	6	4
163	R:R:F141	R:R:S140	2.64	No	No	0	6	4
164	R:R:F141	R:R:F383	18.22	No	No	0	6	5
165	R:R:D195	R:R:Q142	5.22	No	No	0	7	5
166	R:R:Q142	R:R:R199	3.5	No	No	0	5	4
167	R:R:V143	R:R:V147	1.6	No	No	0	4	5
168	R:R:F387	R:R:M144	8.71	No	No	0	5	6
169	R:R:Y145	R:R:Y149	6.95	Yes	Yes	5	7	8
170	R:R:V191	R:R:Y145	8.83	No	Yes	5	7	7
171	R:R:D195	R:R:Y145	6.9	No	Yes	0	7	7
172	R:R:L386	R:R:Y145	8.21	No	Yes	0	7	7
173	R:R:S150	R:R:T146	1.6	No	No	0	7	7
174	R:R:G148	R:R:S390	3.71	No	Yes	5	7	9
175	R:R:F391	R:R:G148	7.53	Yes	No	5	7	7
176	R:R:K187	R:R:Y149	4.78	Yes	Yes	0	8	8
177	R:R:V191	R:R:Y149	10.09	No	Yes	5	7	8
178	R:R:S390	R:R:Y149	3.82	Yes	Yes	5	9	8
179	R:R:L192	R:R:S150	4.5	No	No	0	7	7
180	R:R:F391	R:R:L151	2.44	Yes	No	0	7	5
181	R:R:L151	R:R:L394	4.15	No	Yes	0	5	5
182	R:R:L156	R:R:S152	1.5	Yes	No	1	8	9
183	R:R:G393	R:R:S152	3.71	Yes	No	1	9	9
184	R:R:L394	R:R:S152	4.5	Yes	No	0	5	9
185	R:R:G154	R:R:L153	1.71	No	Yes	0	4	6
186	R:R:L153	R:R:L157	4.15	Yes	No	1	6	3
187	R:R:L153	R:R:V185	1.49	Yes	Yes	1	6	8
188	R:R:A188	R:R:L153	3.15	No	Yes	0	8	6
189	R:R:A155	R:R:L394	3.15	No	Yes	0	6	5
190	R:R:A155	R:R:A397	1.79	No	No	0	6	8
191	R:R:F181	R:R:L156	3.65	Yes	Yes	1	8	8
192	R:R:F184	R:R:L156	2.44	Yes	Yes	1	8	8
193	R:R:L156	R:R:V185	2.98	Yes	Yes	1	8	8
194	R:R:G393	R:R:L156	1.71	Yes	Yes	1	9	8
195	R:R:A397	R:R:L156	3.15	No	Yes	0	8	8
196	R:R:L157	R:R:V185	1.49	No	Yes	1	3	8
197	R:R:F402	R:R:L158	4.87	No	No	0	9	5
198	R:R:A159	R:R:C401	3.61	No	Yes	0	9	9
199	R:R:A159	R:R:F402	2.77	No	No	0	9	9
200	R:R:A178	R:R:L160	1.58	No	No	0	7	6
201	R:R:F181	R:R:L160	3.65	Yes	No	0	8	6
202	R:R:L160	R:R:V185	1.49	No	Yes	0	6	8
203	R:R:C401	R:R:I162	1.64	Yes	No	0	9	8
204	R:R:L163	R:R:N174	9.61	No	Yes	0	8	9
205	R:R:C401	R:R:L163	4.76	Yes	No	0	9	8
206	R:R:L163	R:R:V407	1.49	No	No	0	8	9
207	R:R:G164	R:R:G165	2.11	No	No	0	3	3
208	R:R:K168	R:R:L166	2.82	Yes	No	0	8	7
209	R:R:L166	R:R:R414	4.86	No	No	0	7	5
210	R:R:K168	R:R:S167	3.06	Yes	No	1	8	8
211	R:R:E410	R:R:S167	2.87	Yes	No	1	8	8
212	R:R:C171	R:R:K168	1.62	No	Yes	1	7	8
213	R:R:K168	R:R:N174	4.2	Yes	Yes	1	8	9
214	R:R:E406	R:R:K168	5.4	No	Yes	1	9	8
215	R:R:K168	R:R:V407	7.59	Yes	No	0	8	9
216	R:R:E410	R:R:K168	6.75	Yes	Yes	1	8	8
217	R:R:H170	R:R:L169	6.43	No	No	0	7	9
218	R:R:C171	R:R:N174	9.45	No	Yes	1	7	9
219	R:R:T172	R:R:Y248	2.5	No	Yes	1	7	8
220	R:R:E260	R:R:T172	5.64	No	No	1	6	7
221	R:R:R261	R:R:T172	3.88	No	No	0	5	7
222	R:R:H177	R:R:R173	2.26	Yes	Yes	1	9	9
223	R:R:R173	R:R:Y248	6.17	Yes	Yes	1	9	8
224	R:R:R173	R:R:Y343	3.09	Yes	No	1	9	7
225	R:R:L347	R:R:R173	8.5	Yes	Yes	1	9	9
226	R:R:N404	R:R:R173	6.03	No	Yes	0	9	9
227	R:R:H177	R:R:N174	2.55	Yes	Yes	1	9	9
228	R:R:I176	R:R:W241	2.35	Yes	Yes	1	9	9
229	R:R:I176	R:R:V244	3.07	Yes	Yes	1	9	8
230	R:R:E245	R:R:I176	6.83	Yes	Yes	1	9	9
231	R:R:I176	R:R:Y248	6.04	Yes	Yes	1	9	8
232	R:R:F181	R:R:H177	2.26	Yes	Yes	1	8	9
233	R:R:E245	R:R:H177	11.08	Yes	Yes	1	9	9
234	R:R:H177	R:R:L347	2.57	Yes	Yes	1	9	9
235	R:R:H177	R:R:Y400	11.98	Yes	Yes	1	9	8
236	R:R:N179	R:R:W241	14.69	No	Yes	1	8	9
237	R:R:N179	R:R:W272	10.17	No	Yes	1	8	9
238	R:R:L180	R:R:W241	2.28	Yes	Yes	1	9	9
239	R:R:E245	R:R:L180	5.3	Yes	Yes	1	9	9
240	R:R:L180	R:R:V396	2.98	Yes	Yes	0	9	9
241	R:R:L180	R:R:Y400	2.34	Yes	Yes	1	9	8
242	R:R:F181	R:R:V396	2.62	Yes	Yes	0	8	9
243	R:R:F181	R:R:Y400	2.06	Yes	Yes	1	8	8
244	R:R:C401	R:R:F181	2.79	Yes	Yes	0	9	8
245	R:R:A182	R:R:W272	2.59	No	Yes	0	4	9
246	R:R:A237	R:R:S183	1.71	No	No	0	7	9
247	R:R:N238	R:R:S183	7.45	No	No	0	9	9
248	R:R:S183	R:R:W272	2.47	No	Yes	0	9	9
249	R:R:F184	R:R:N238	25.37	Yes	No	0	8	9
250	R:R:F184	R:R:Q392	8.2	Yes	Yes	1	8	9
251	R:R:F184	R:R:G393	4.52	Yes	Yes	1	8	9
252	R:R:F184	R:R:V396	7.87	Yes	Yes	0	8	9
253	R:R:F230	R:R:L186	2.44	No	No	0	4	7
254	R:R:I235	R:R:K187	4.36	No	Yes	0	5	8
255	R:R:K187	R:R:N238	5.6	Yes	No	0	8	9
256	R:R:K187	R:R:Q392	4.07	Yes	Yes	0	8	9
257	R:R:M231	R:R:S190	4.6	No	No	0	6	5
258	R:R:M231	R:R:V191	3.04	No	No	0	6	7
259	R:R:L197	R:R:V193	1.49	Yes	No	0	4	5
260	R:R:A227	R:R:V193	3.39	No	No	0	6	5
261	R:R:A227	R:R:I194	3.25	No	No	0	6	6
262	R:R:C294	R:R:I194	1.64	No	No	0	9	6
263	R:R:A220	R:R:L197	3.15	No	Yes	0	6	4
264	R:R:G223	R:R:L197	1.71	No	Yes	0	3	4
265	R:R:C224	R:R:L197	3.17	No	Yes	0	9	4
266	R:R:L198	R:R:R201	13.36	No	No	0	6	4
267	R:R:C294	R:R:L198	3.17	No	No	0	9	6
268	R:R:R201	R:R:V212	6.54	No	No	0	4	3
269	R:R:L216	R:R:R201	3.64	No	No	0	2	4
270	R:R:S213	R:R:Y202	5.09	No	Yes	0	3	1
271	R:R:L210	R:R:S203	3	Yes	No	10	4	4
272	R:R:S203	R:R:V212	4.85	No	No	10	4	3
273	R:R:K205	R:R:L210	2.82	No	Yes	0	4	4
274	R:R:I206	R:R:S211	4.64	No	No	9	4	4
275	R:R:L210	R:R:V212	2.98	Yes	No	10	4	3
276	R:R:Q293	R:R:T214	9.92	No	Yes	0	4	1
277	R:R:A220	R:R:L216	3.15	No	No	0	6	2
278	R:R:L216	R:R:V221	1.49	No	No	0	2	4
279	R:R:G219	R:R:S217	1.86	No	No	0	3	4
280	R:R:A220	R:R:S217	1.71	No	No	0	6	4
281	R:R:R225	R:R:V221	2.62	Yes	No	0	8	4
282	R:R:C224	R:R:C294	5.46	No	No	0	9	9
283	R:R:C287	R:R:R225	4.18	No	Yes	4	3	8
284	R:R:N291	R:R:R225	12.05	No	Yes	0	6	8
285	R:R:R225	R:R:W295	9	Yes	Yes	4	8	9
286	R:R:F230	R:R:V226	2.62	No	No	0	4	4
287	R:R:A228	R:R:W295	2.59	No	Yes	0	5	9
288	R:R:Q232	R:R:V229	4.3	Yes	No	4	7	6
289	R:R:A283	R:R:V229	3.39	No	No	4	5	6
290	R:R:V229	R:R:W295	3.68	No	Yes	4	6	9
291	R:R:I235	R:R:M231	2.92	No	No	0	5	6
292	R:R:A283	R:R:Q232	1.52	No	Yes	4	5	7
293	R:R:Q232	R:R:W295	2.19	Yes	Yes	4	7	9
294	R:R:L307	R:R:Q232	7.99	Yes	Yes	0	7	7
295	R:R:W272	R:R:Y233	6.75	Yes	Yes	0	9	9
296	R:R:P275	R:R:Y233	4.17	Yes	Yes	0	9	9
297	R:R:M276	R:R:Y233	10.78	No	Yes	0	3	9
298	R:R:V279	R:R:Y233	3.79	Yes	Yes	0	6	9
299	R:R:A237	R:R:G234	1.95	No	No	0	7	5
300	R:R:C240	R:R:V236	1.71	Yes	Yes	3	6	6
301	R:R:P275	R:R:V236	5.3	Yes	Yes	3	9	6
302	R:R:V236	R:R:V279	3.21	Yes	Yes	0	6	6
303	R:R:P310	R:R:V236	5.3	No	Yes	0	9	6
304	R:R:V236	R:R:V311	4.81	Yes	No	3	6	8
305	R:R:A237	R:R:P275	1.87	No	Yes	0	7	9
306	R:R:V311	R:R:Y239	7.57	No	Yes	3	8	8
307	R:R:I315	R:R:Y239	4.84	Yes	Yes	3	7	8
308	R:R:L358	R:R:Y239	10.55	Yes	Yes	0	9	8
309	R:R:E362	R:R:Y239	6.73	No	Yes	0	8	8
310	R:R:C240	R:R:G271	1.96	Yes	No	0	6	9
311	R:R:A274	R:R:C240	1.81	No	Yes	3	4	6
312	R:R:C240	R:R:P275	5.65	Yes	Yes	3	6	9
313	R:R:V244	R:R:W241	8.58	Yes	Yes	1	8	9
314	R:R:L268	R:R:W241	11.39	No	Yes	1	5	9
315	R:R:G271	R:R:W241	8.44	No	Yes	0	9	9
316	R:R:W241	R:R:W272	19.68	Yes	Yes	1	9	9
317	R:R:I355	R:R:L242	2.85	Yes	No	0	8	9
318	R:R:L242	R:R:L358	4.15	No	Yes	0	9	9
319	R:R:L243	R:R:L247	2.77	Yes	Yes	0	8	7
320	R:R:I270	R:R:L243	4.28	Yes	Yes	0	7	8
321	R:R:I317	R:R:L243	2.85	No	Yes	0	6	8
322	R:R:L243	R:R:N318	10.98	Yes	No	0	8	9
323	R:R:F264	R:R:V244	2.62	Yes	Yes	1	6	8
324	R:R:L268	R:R:V244	1.49	No	Yes	1	5	8
325	R:R:I270	R:R:V244	1.54	Yes	Yes	0	7	8
326	R:R:E245	R:R:G246	1.64	Yes	Yes	1	9	9
327	R:R:E245	R:R:T351	2.82	Yes	Yes	1	9	9
328	R:R:E245	R:R:Y400	19.08	Yes	Yes	1	9	8
329	R:R:G246	R:R:I321	1.76	Yes	Yes	0	9	8
330	R:R:G246	R:R:T351	1.82	Yes	Yes	1	9	9
331	R:R:G246	R:R:I355	1.76	Yes	Yes	1	9	8
332	R:R:L247	R:R:N251	2.75	Yes	No	1	7	7
333	R:R:F264	R:R:L247	2.44	Yes	Yes	1	6	7
334	R:R:I321	R:R:L247	2.85	Yes	Yes	0	8	7
335	R:R:L252	R:R:Y248	4.69	No	Yes	1	8	8
336	R:R:E260	R:R:Y248	3.37	No	Yes	1	6	8
337	R:R:F264	R:R:Y248	5.16	Yes	Yes	1	6	8
338	R:R:L347	R:R:Y248	2.34	Yes	Yes	1	9	8
339	R:R:L249	R:R:L347	4.15	No	Yes	0	9	9
340	R:R:A348	R:R:L249	1.58	No	No	0	7	9
341	R:R:L249	R:R:T351	7.37	No	Yes	0	9	9
342	R:R:H250	R:R:R324	5.64	No	No	0	7	8
343	R:R:F263	R:R:N251	8.46	Yes	No	1	5	7
344	R:R:F264	R:R:N251	4.83	Yes	No	1	6	7
345	R:R:E260	R:R:L252	10.6	No	No	1	6	8
346	R:R:F263	R:R:L252	2.44	Yes	No	1	5	8
347	R:R:L253	R:R:L328	2.77	No	No	0	8	8
348	R:R:G254	R:R:L328	3.42	No	No	0	6	8
349	R:R:A256	R:R:Q337	1.52	No	No	0	7	7
350	R:R:R261	R:R:S265	3.95	No	No	0	5	3
351	R:R:F263	R:R:S262	2.64	Yes	No	0	5	5
352	R:R:F263	R:R:F264	6.43	Yes	Yes	1	5	6
353	R:R:F263	R:R:Y267	3.09	Yes	No	0	5	7
354	R:R:L268	R:R:S265	3	No	No	0	5	3
355	R:R:L266	R:R:Y267	5.86	No	No	0	3	7
356	R:R:G271	R:R:I270	1.76	No	Yes	0	9	7
357	R:R:A274	R:R:I270	1.62	No	Yes	0	4	7
358	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
359	R:R:A274	R:R:P275	1.87	No	Yes	3	4	9
360	R:R:M276	R:R:V280	3.04	No	No	0	3	2
361	R:R:F278	R:R:P310	23.12	No	No	0	5	9
362	R:R:V279	R:R:V280	1.6	Yes	No	0	6	2
363	R:R:L307	R:R:V279	1.49	Yes	Yes	0	7	6
364	R:R:P281	R:R:V280	3.53	No	No	0	4	2
365	R:R:V285	R:R:W282	2.45	No	Yes	0	5	9
366	R:R:K286	R:R:W282	24.37	No	Yes	6	8	9
367	R:R:G302	R:R:W282	5.63	Yes	Yes	6	2	9
368	R:R:I306	R:R:W282	42.28	No	Yes	6	8	9
369	R:R:L307	R:R:W282	2.28	Yes	Yes	0	7	9
370	R:R:L288	R:R:V284	1.49	No	No	0	1	4
371	R:R:G302	R:R:K286	3.49	Yes	No	6	2	8
372	R:R:C287	R:R:L288	3.17	No	No	0	3	1
373	R:R:C287	R:R:W295	5.22	No	Yes	4	3	9
374	R:R:E290	R:R:V292	4.28	No	No	4	6	4
375	R:R:E290	R:R:S297	2.87	No	Yes	4	6	4
376	R:R:D299	R:R:E290	2.6	No	No	4	4	6
377	R:R:V292	R:R:W295	3.68	No	Yes	4	4	9
378	R:R:S297	R:R:V292	1.62	Yes	No	4	4	4
379	R:R:D299	R:R:S297	4.42	No	Yes	4	4	4
380	R:R:F303	R:R:S297	6.61	No	Yes	0	4	4
381	R:R:H372	R:R:N298	8.93	No	No	0	4	6
382	R:R:D370	R:R:N300	5.39	No	No	0	4	5
383	R:R:G302	R:R:M301	1.75	Yes	No	0	2	5
384	R:R:G302	R:R:I306	3.53	Yes	No	6	2	8
385	R:R:F303	R:R:L307	4.87	No	Yes	0	4	7
386	R:R:W304	R:R:W305	3.75	Yes	No	0	6	7
387	R:R:R308	R:R:W304	25.99	Yes	Yes	3	6	6
388	R:R:F312	R:R:W304	7.02	Yes	Yes	3	5	6
389	R:R:F367	R:R:W304	8.02	No	Yes	3	5	6
390	R:R:F312	R:R:R308	24.59	Yes	Yes	3	5	6
391	R:R:R308	R:R:V363	2.62	Yes	No	3	6	6
392	R:R:A366	R:R:R308	6.91	No	Yes	3	7	6
393	R:R:F367	R:R:R308	9.62	No	Yes	3	5	6
394	R:R:I315	R:R:V311	1.54	Yes	No	3	7	8
395	R:R:F312	R:R:V363	6.55	Yes	No	3	5	6
396	R:R:A366	R:R:F312	2.77	No	Yes	3	7	5
397	R:R:I317	R:R:L313	2.85	No	No	0	6	3
398	R:R:A314	R:R:N318	1.56	No	No	0	8	9
399	R:R:F319	R:R:I315	2.51	No	Yes	3	7	7
400	R:R:G359	R:R:I315	5.29	No	Yes	3	9	7
401	R:R:I315	R:R:V363	1.54	Yes	No	3	7	6
402	R:R:I317	R:R:I321	2.94	No	Yes	0	6	8
403	R:R:I355	R:R:N318	8.5	Yes	No	0	8	9
404	R:R:F319	R:R:G359	1.51	No	No	3	7	9
405	R:R:I321	R:R:I325	2.94	Yes	No	0	8	9
406	R:R:F322	R:R:V326	2.62	No	No	0	9	7
407	R:R:F322	R:R:L352	2.44	No	Yes	0	9	8
408	R:R:Q327	R:R:R324	12.85	No	No	0	8	8
409	R:R:L328	R:R:R324	9.72	No	No	0	8	8
410	R:R:I325	R:R:L352	2.85	No	Yes	0	9	8
411	R:R:V326	R:R:V330	1.6	No	No	0	7	6
412	R:R:F345	R:R:L329	4.87	Yes	No	0	7	9
413	R:R:K332	R:R:Q337	16.27	No	No	0	9	7
414	R:R:K332	R:R:M338	2.88	No	Yes	0	9	5
415	R:R:L333	R:R:M338	4.24	Yes	Yes	1	7	5
416	R:R:H340	R:R:L333	2.57	No	Yes	0	5	7
417	R:R:F345	R:R:L333	2.44	Yes	Yes	1	7	7
418	R:R:Q337	R:R:R336	8.18	No	No	0	7	5
419	R:R:F345	R:R:M338	7.46	Yes	Yes	1	7	5
420	R:R:H339	R:R:H340	9.55	No	No	0	4	5
421	R:R:D342	R:R:Y343	3.45	No	No	1	7	7
422	R:R:D342	R:R:K344	6.91	No	No	1	7	6
423	R:R:K344	R:R:Y343	13.14	No	No	1	6	7
424	R:R:F345	R:R:K349	2.48	Yes	No	1	7	9
425	R:R:F345	W:W:?2	4.97	Yes	Yes	1	7	0
426	R:R:K405	R:R:R346	6.19	No	No	0	6	8
427	R:R:R346	W:W:?2	1.65	No	Yes	0	8	0
428	R:R:L347	R:R:Y400	3.52	Yes	Yes	1	9	8
429	R:R:L347	W:W:?2	1.88	Yes	Yes	1	9	0
430	R:R:A348	R:R:L352	3.15	No	Yes	0	7	8
431	R:R:K349	W:W:?2	23.03	No	Yes	1	9	0
432	R:R:L399	R:R:S350	3	Yes	No	1	8	9
433	R:R:S350	R:R:Y400	7.63	No	Yes	1	9	8
434	R:R:S350	W:W:?2	10.22	No	Yes	1	9	0
435	R:R:I355	R:R:T351	1.52	Yes	Yes	1	8	9
436	R:R:T351	R:R:Y400	7.49	Yes	Yes	1	9	8
437	R:R:L352	W:W:?2	5.65	Yes	Yes	0	8	0
438	R:R:T353	W:W:?2	18.06	No	Yes	0	8	0
439	R:R:L354	R:R:L358	2.77	No	Yes	0	9	9
440	R:R:L354	R:R:V396	5.96	No	Yes	0	9	9
441	R:R:L354	R:R:Y400	3.52	No	Yes	0	9	8
442	R:R:I355	R:R:P356	3.39	Yes	No	0	8	9
443	R:R:L357	R:R:L395	2.77	No	No	0	9	6
444	R:R:L358	R:R:Q392	9.32	Yes	Yes	0	9	9
445	R:R:V360	R:R:V364	1.6	No	No	0	6	6
446	R:R:E362	R:R:H361	2.46	No	Yes	0	8	8
447	R:R:D385	R:R:H361	8.82	Yes	Yes	0	7	8
448	R:R:H361	R:R:L388	6.43	Yes	No	0	8	6
449	R:R:H361	R:R:S389	5.58	Yes	No	1	8	6
450	R:R:H361	R:R:Q392	3.71	Yes	Yes	1	8	9
451	R:R:F365	R:R:T369	3.89	No	No	0	7	7
452	R:R:F365	R:R:L382	4.87	No	No	0	7	5
453	R:R:D385	R:R:F365	11.94	Yes	No	0	7	7
454	R:R:T369	R:R:V368	1.59	No	No	0	7	5
455	R:R:K381	R:R:T369	12.01	No	No	0	7	7
456	R:R:D370	R:R:H372	2.52	No	No	0	4	4
457	R:R:A373	R:R:E371	1.51	No	No	0	3	5
458	R:R:H372	R:R:R378	3.39	No	Yes	0	4	4
459	R:R:G375	R:R:Q374	3.29	No	Yes	0	2	4
460	R:R:L377	R:R:Q374	5.32	No	Yes	0	3	4
461	R:R:L382	R:R:R378	6.07	No	Yes	0	5	4
462	R:R:L382	R:R:L386	2.77	No	No	0	5	7
463	R:R:F387	R:R:S390	2.64	No	Yes	5	5	9
464	R:R:F387	R:R:F391	9.65	No	Yes	5	5	7
465	R:R:Q392	R:R:S389	2.89	Yes	No	1	9	6
466	R:R:F391	R:R:S390	3.96	Yes	Yes	5	7	9
467	R:R:G393	R:R:Q392	1.64	Yes	Yes	1	9	9
468	R:R:L394	R:R:V398	2.98	Yes	No	0	5	6
469	R:R:L395	R:R:L399	2.77	No	Yes	0	6	8
470	R:R:L399	R:R:V398	1.49	Yes	No	1	8	6
471	R:R:L403	R:R:V398	2.98	No	No	1	5	6
472	R:R:L399	R:R:L403	2.77	Yes	No	1	8	5
473	R:R:L399	W:W:?2	6.59	Yes	Yes	1	8	0
474	R:R:Y400	W:W:?2	1.6	Yes	Yes	1	8	0
475	R:R:L403	W:W:?2	2.83	No	Yes	1	5	0
476	R:R:N404	R:R:V407	4.43	No	No	0	9	9
477	R:R:N404	W:W:?2	10.28	No	Yes	0	9	0
478	R:R:K405	R:R:S409	1.53	No	No	11	6	4
479	R:R:K405	R:R:R412	3.71	No	No	11	6	5
480	R:R:E406	R:R:E410	6.34	No	Yes	1	9	8
481	R:R:R412	R:R:S409	2.64	No	No	11	5	4
482	R:R:H416	R:R:W415	12.7	No	No	0	3	5
483	R:R:D385	R:R:V364	1.46	Yes	No	0	7	6
484	R:R:D195	R:R:T146	1.45	No	No	0	7	7
485	R:R:F309	R:R:P310	1.44	No	No	0	4	9
486	R:R:E55	R:R:V57	1.43	No	Yes	0	4	3
487	R:R:E55	R:R:T54	1.41	No	No	0	4	1
488	R:R:G109	R:R:W115	1.41	Yes	No	0	4	4
489	R:R:L253	R:R:M338	1.41	No	Yes	0	8	5
490	R:R:K344	R:R:L253	1.41	No	No	0	6	8
491	R:R:L49	R:R:L50	1.38	No	No	0	2	3
492	R:R:D208	R:R:K132	1.38	No	No	0	4	2
493	R:R:L313	R:R:L316	1.38	No	No	0	3	3
494	R:R:A335	R:R:R336	1.38	No	No	0	7	5
495	R:R:F230	R:R:S190	1.32	No	No	0	4	5
496	R:R:R378	R:R:S379	1.32	Yes	No	0	4	3
497	R:R:H45	R:R:L49	1.29	No	No	0	4	2
498	R:R:R346	R:R:T341	1.29	No	No	0	8	6
499	R:R:E371	R:R:Q374	1.27	No	Yes	0	5	4
500	R:R:V134	R:R:Y138	1.26	No	No	0	2	5
501	R:R:F278	R:R:L277	1.22	No	No	0	5	4
502	R:R:L333	R:R:R334	1.21	Yes	No	0	7	7
503	R:R:K35	R:R:Y84	1.19	No	Yes	0	4	5
504	R:R:D385	R:R:F384	1.19	Yes	No	0	7	4
505	R:R:F31	R:R:Q27	1.17	No	No	0	4	5
506	R:R:Q374	R:R:R378	1.17	Yes	Yes	0	4	4
507	R:R:Q408	R:R:R412	1.17	No	No	0	7	5
508	R:R:K90	R:R:W87	1.16	No	Yes	2	4	3
509	R:R:K90	R:R:W215	1.16	No	Yes	2	4	2
510	R:R:E410	R:R:R413	1.16	Yes	No	0	8	7
511	R:R:F383	R:R:Y138	1.03	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	H:H:?7	15	6	2	0
2	H:H:?9	18.25	4	0	0
3	R:R:W36	5.2375	4	0	6
4	R:R:Y39	6.81667	6	2	6
5	R:R:C43	4.5	4	2	9
6	R:R:P53	2.47	4	7	3
7	R:R:V57	2.3375	4	7	3
8	R:R:F62	4.856	5	2	7
9	R:R:D63	9.0975	4	2	9
10	R:R:Y65	5.99625	8	2	6
11	R:R:S66	4.25167	6	2	5
12	R:R:W68	6.10143	7	2	9
13	R:R:T71	4.43	5	2	7
14	R:R:P82	5.78	7	2	8
15	R:R:W83	4.34429	7	2	2
16	R:R:Y84	5.84143	7	2	5
17	R:R:L85	4.12833	6	2	6
18	R:R:P86	7.05	5	2	3
19	R:R:W87	8.565	6	2	3
20	R:R:V96	2.79571	7	2	7
21	R:R:F97	4.958	5	8	5
22	R:R:K98	9.074	5	2	8
23	R:R:W106	8.61833	6	2	9
24	R:R:G109	2.975	4	2	4
25	R:R:Q113	3.91	5	2	4
26	R:R:P114	2.7325	4	2	5
27	R:R:R116	7.184	5	2	6
28	R:R:C121	3.298	5	2	9
29	R:R:M123	4.925	4	2	3
30	R:R:Y145	7.7225	4	5	7
31	R:R:Y149	6.41	4	5	8
32	R:R:L153	2.625	4	1	6
33	R:R:L156	2.57167	6	1	8
34	R:R:K168	4.49143	7	1	8
35	R:R:R173	5.21	5	1	9
36	R:R:N174	6.4525	4	1	9
37	R:R:I176	4.5725	4	1	9
38	R:R:H177	5.45	6	1	9
39	R:R:L180	3.225	4	1	9
40	R:R:F181	2.83833	6	1	8
41	R:R:F184	9.68	5	1	8
42	R:R:V185	1.8625	4	1	8
43	R:R:K187	4.7025	4	0	8
44	R:R:L197	2.38	4	0	4
45	R:R:Y202	8.084	5	2	1
46	R:R:L210	2.9875	4	10	4
47	R:R:T214	4.0725	4	2	1
48	R:R:W215	4.5675	4	2	2
49	R:R:R225	6.9625	4	4	8
50	R:R:Q232	4	4	4	7
51	R:R:Y233	6.3725	4	0	9
52	R:R:V236	4.066	5	3	6
53	R:R:Y239	7.4225	4	3	8
54	R:R:C240	2.7825	4	3	6
55	R:R:W241	9.63	7	1	9
56	R:R:L243	5.22	4	0	8
57	R:R:V244	3.46	5	1	8
58	R:R:E245	7.79167	6	1	9
59	R:R:G246	1.745	4	1	9
60	R:R:L247	2.7025	4	1	7
61	R:R:Y248	4.32429	7	1	8
62	R:R:F263	4.612	5	1	5
63	R:R:F264	4.296	5	1	6
64	R:R:I270	2.3	4	0	7
65	R:R:W272	8.332	5	1	9
66	R:R:P275	3.48167	6	3	9
67	R:R:V279	2.5225	4	0	6
68	R:R:W282	15.402	5	6	9
69	R:R:W295	4.39333	6	4	9
70	R:R:S297	3.88	4	4	4
71	R:R:G302	3.6	4	6	2
72	R:R:W304	11.195	4	3	6
73	R:R:L307	4.1575	4	0	7
74	R:R:R308	13.946	5	3	6
75	R:R:F312	10.2325	4	3	5
76	R:R:I315	3.144	5	3	7
77	R:R:I321	2.6225	4	0	8
78	R:R:L333	2.615	4	1	7
79	R:R:M338	3.9975	4	1	5
80	R:R:F345	4.444	5	1	7
81	R:R:L347	3.82667	6	1	9
82	R:R:T351	4.204	5	1	9
83	R:R:L352	3.5225	4	0	8
84	R:R:I355	3.604	5	1	8
85	R:R:L358	6.6975	4	0	9
86	R:R:H361	5.4	5	1	8
87	R:R:Q374	2.7625	4	0	4
88	R:R:R378	2.9875	4	0	4
89	R:R:D385	5.8525	4	0	7
90	R:R:S390	3.5325	4	5	9
91	R:R:F391	5.895	4	5	7
92	R:R:Q392	4.97167	6	1	9
93	R:R:G393	2.895	4	1	9
94	R:R:L394	3.695	4	0	5
95	R:R:V396	4.8575	4	0	9
96	R:R:L399	3.324	5	1	8
97	R:R:Y400	6.58	9	1	8
98	R:R:C401	3.2	4	0	9
99	R:R:E410	4.28	4	1	8
100	W:W:?2	7.88727	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?9	R:R:P53	22.8648	2.94	Yes	Yes	0	0	3
2	R:R:D70	R:R:P53	17.4347	3.22	No	Yes	7	4	3
3	R:R:D70	R:R:R60	20.0504	14.29	No	No	0	4	4
4	R:R:L47	R:R:R60	35.0621	10.93	No	No	0	5	4
5	R:R:C67	R:R:L47	18.8295	4.76	No	No	2	9	5
6	H:H:?7	R:R:C67	20.124	2.84	Yes	No	2	0	9
7	R:R:P82	R:R:Y39	16.1565	5.56	Yes	Yes	2	8	6
8	H:H:?7	R:R:Y39	15.2528	5.24	Yes	Yes	2	0	6
9	R:R:L85	R:R:P82	23.3056	4.93	Yes	Yes	2	6	8
10	R:R:L85	R:R:P86	47.2531	3.28	Yes	Yes	2	6	3
11	R:R:P86	R:R:Y202	47.4213	11.13	Yes	Yes	2	3	1
12	R:R:Y39	R:R:Y84	15.7041	9.93	Yes	Yes	2	6	5
13	R:R:L85	R:R:Y84	35.7025	3.52	Yes	Yes	2	6	5
14	R:R:W83	R:R:Y84	10.5298	1.93	Yes	Yes	2	2	5
15	R:R:F62	R:R:Y39	16.1076	4.13	Yes	Yes	2	7	6
16	R:R:L50	R:R:R60	12.6171	2.43	No	No	0	3	4
17	R:R:S66	R:R:W68	13.7587	4.94	Yes	Yes	2	5	9
18	R:R:A77	R:R:W68	23.6024	2.59	No	Yes	2	7	9
19	R:R:A77	R:R:T71	21.7847	5.03	No	Yes	2	7	7
20	R:R:P72	R:R:T71	25.1154	5.25	No	Yes	0	1	7
21	R:R:P72	R:R:V57	20.9346	1.77	No	Yes	0	1	3
22	R:R:R116	R:R:Y65	12.7374	12.35	Yes	Yes	2	6	6
23	R:R:L85	R:R:W87	47.81	9.11	Yes	Yes	2	6	3
24	R:R:M123	R:R:W87	51.9551	11.63	Yes	Yes	2	3	3
25	R:R:S213	R:R:Y202	47.4806	5.09	No	Yes	0	3	1
26	R:R:M123	R:R:S213	52.2861	3.07	Yes	No	0	3	3
27	R:R:E127	R:R:S213	99.6827	4.31	No	No	0	1	3
28	R:R:E127	R:R:S211	100	8.62	No	No	0	1	4
29	R:R:E129	R:R:S211	99.668	4.31	No	No	9	1	4
30	R:R:D209	R:R:E129	99.7967	16.89	No	No	0	4	1
31	R:R:D209	R:R:Q131	99.7268	7.83	No	No	0	4	3
32	R:R:Q131	R:R:V134	99.6559	5.73	No	No	0	3	2
33	R:R:V130	R:R:V134	99.2083	3.21	No	No	0	1	2
34	R:R:A135	R:R:V130	99.13	3.39	No	No	0	3	1
35	R:R:A135	R:R:L210	99.0507	3.15	No	Yes	0	3	4
36	R:R:L210	R:R:V212	98.4491	2.98	Yes	No	10	4	3
37	R:R:R201	R:R:V212	98.5526	6.54	No	No	0	4	3
38	R:R:L216	R:R:R201	97.638	3.64	No	No	0	2	4
39	R:R:L216	R:R:V221	97.3438	1.49	No	No	0	2	4
40	R:R:R225	R:R:V221	97.2434	2.62	Yes	No	0	8	4
41	R:R:R225	R:R:W295	96.1901	9	Yes	Yes	4	8	9
42	R:R:Q232	R:R:W295	94.4023	2.19	Yes	Yes	4	7	9
43	R:R:L307	R:R:Q232	94.3445	7.99	Yes	Yes	0	7	7
44	R:R:L307	R:R:V279	94.0571	1.49	Yes	Yes	0	7	6
45	R:R:V279	R:R:Y233	64.1766	3.79	Yes	Yes	0	6	9
46	R:R:W272	R:R:Y233	59.1757	6.75	Yes	Yes	0	9	9
47	R:R:S183	R:R:W272	12.9181	2.47	No	Yes	0	9	9
48	R:R:N238	R:R:S183	12.8488	7.45	No	No	0	9	9
49	R:R:V236	R:R:V279	29.353	3.21	Yes	Yes	0	6	6
50	R:R:V236	R:R:V311	15.9841	4.81	Yes	No	3	6	8
51	R:R:V311	R:R:Y239	11.3494	7.57	No	Yes	3	8	8
52	R:R:W241	R:R:W272	46.6957	19.68	Yes	Yes	1	9	9
53	R:R:L180	R:R:W241	32.036	2.28	Yes	Yes	1	9	9
54	R:R:L180	R:R:Y400	22.8422	2.34	Yes	Yes	1	9	8
55	R:R:I176	R:R:W241	11.8017	2.35	Yes	Yes	1	9	9
56	R:R:H177	R:R:N174	11.0667	2.55	Yes	Yes	1	9	9
57	R:R:Y400	W:W:?2	15.0999	1.6	Yes	Yes	1	8	0
58	R:R:A274	R:R:I270	11.3384	1.62	No	Yes	0	4	7
59	R:R:I270	R:R:L243	13.4514	4.28	Yes	Yes	0	7	8
60	R:R:C43	R:R:L47	18.8064	3.17	Yes	No	2	9	5
61	R:R:C43	R:R:F62	20.0867	5.59	Yes	Yes	2	9	7
62	R:R:P53	R:R:V57	14.5909	1.77	Yes	Yes	7	3	3
63	R:R:V96	R:R:W68	13.4671	3.68	Yes	Yes	2	7	9
64	R:R:L85	R:R:Y65	27.986	2.34	Yes	Yes	2	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H177	R:R:R173	2.26	1	Yes	Yes	9	9	2	2
R:R:R173	R:R:Y248	6.17	1	Yes	Yes	9	8	2	2
R:R:L347	R:R:R173	8.5	1	Yes	Yes	9	9	1	2
R:R:N404	R:R:R173	6.03	0	No	Yes	9	9	1	2
R:R:F181	R:R:H177	2.26	1	Yes	Yes	8	9	2	2
R:R:E245	R:R:H177	11.08	1	Yes	Yes	9	9	2	2
R:R:H177	R:R:L347	2.57	1	Yes	Yes	9	9	2	1
R:R:H177	R:R:Y400	11.98	1	Yes	Yes	9	8	2	1
R:R:E245	R:R:L180	5.3	1	Yes	Yes	9	9	2	2
R:R:L180	R:R:Y400	2.34	1	Yes	Yes	9	8	2	1
R:R:F181	R:R:Y400	2.06	1	Yes	Yes	8	8	2	1
R:R:E245	R:R:T351	2.82	1	Yes	Yes	9	9	2	2
R:R:E245	R:R:Y400	19.08	1	Yes	Yes	9	8	2	1
R:R:L347	R:R:Y248	2.34	1	Yes	Yes	9	8	1	2
R:R:L249	R:R:L347	4.15	0	No	Yes	9	9	2	1
R:R:A348	R:R:L249	1.58	0	No	No	7	9	2	2
R:R:L249	R:R:T351	7.37	0	No	Yes	9	9	2	2
R:R:F322	R:R:L352	2.44	0	No	Yes	9	8	2	1
R:R:I325	R:R:L352	2.85	0	No	Yes	9	8	2	1
R:R:F345	R:R:L329	4.87	1	Yes	No	7	9	1	2
R:R:L333	R:R:M338	4.24	1	Yes	Yes	7	5	2	2
R:R:F345	R:R:L333	2.44	1	Yes	Yes	7	7	1	2
R:R:F345	R:R:M338	7.46	1	Yes	Yes	7	5	1	2
R:R:F345	R:R:K349	2.48	1	Yes	No	7	9	1	1
R:R:F345	W:W:?2	4.97	1	Yes	Yes	7	0	1	0
R:R:K405	R:R:R346	6.19	11	No	No	6	8	2	1
R:R:R346	W:W:?2	1.65	0	No	Yes	8	0	1	0
R:R:L347	R:R:Y400	3.52	1	Yes	Yes	9	8	1	1
R:R:L347	W:W:?2	1.88	1	Yes	Yes	9	0	1	0
R:R:A348	R:R:L352	3.15	0	No	Yes	7	8	2	1
R:R:K349	W:W:?2	23.03	1	No	Yes	9	0	1	0
R:R:L399	R:R:S350	3	1	Yes	No	8	9	1	1
R:R:S350	R:R:Y400	7.63	1	No	Yes	9	8	1	1
R:R:S350	W:W:?2	10.22	1	No	Yes	9	0	1	0
R:R:T351	R:R:Y400	7.49	1	Yes	Yes	9	8	2	1
R:R:L352	W:W:?2	5.65	0	Yes	Yes	8	0	1	0
R:R:T353	W:W:?2	18.06	0	No	Yes	8	0	1	0
R:R:L354	R:R:Y400	3.52	0	No	Yes	9	8	2	1
R:R:L395	R:R:L399	2.77	0	No	Yes	6	8	2	1
R:R:L399	R:R:V398	1.49	1	Yes	No	8	6	1	2
R:R:L403	R:R:V398	2.98	1	No	No	5	6	1	2
R:R:L399	R:R:L403	2.77	1	Yes	No	8	5	1	1
R:R:L399	W:W:?2	6.59	1	Yes	Yes	8	0	1	0
R:R:Y400	W:W:?2	1.6	1	Yes	Yes	8	0	1	0
R:R:L403	W:W:?2	2.83	1	No	Yes	5	0	1	0
R:R:N404	R:R:V407	4.43	0	No	No	9	9	1	2
R:R:N404	W:W:?2	10.28	0	No	Yes	9	0	1	0
R:R:R346	R:R:T341	1.29	0	No	No	8	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
72.73	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
63.64	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
62.50	Single	6LN2	PF-06372222	6LN2-GLP-1-PF-06372222
61.54	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
58.33	Single	6KK7	PF-06372222	6KK7-GLP-1-PF-06372222
53.85	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
53.85	Single	6KJV	PF-06372222	6KJV-GLP-1-PF-06372222
53.85	Single	6KK1	PF-06372222	6KK1-GLP-1-PF-06372222
31.58	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
31.25	Single	5X7D	Cmpd-15	5X7D-β₂-S-Carazolol-Cmpd-15
26.67	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
25.00	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
21.43	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
19.05	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
18.75	Single	5T1A	PubChem 12093170	5T1A-CCR2-BMS-681-PubChem 12093170
18.18	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.67	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.79	Single	8JPF	SBI-553	8JPF-NTS₁-Neurotensin-SBI-553
15.79	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.38	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
15.38	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.00	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
15.00	Single	8GW8	PCO371	8GW8-PTH1-PCO371-Gs/β1/γ2
14.29	Single	8JPB	SBI-553; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
13.64	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
13.64	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.64	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.53	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
10.53	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
10.53	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
10.00	Single	8JPC	SBI-553; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
9.09	Single	7DUR	PubChem 156022738	7DUR-GLP-1-PubChem 156022738-Gs/β1/γ2
9.09	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.33	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
7.69	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
7.14	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
5.56	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
5.26	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
5.26	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.26	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.26	Single	9CLW	4-CMTB	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Single	6QZH	Cmp2105; Na	6QZH-CCR7-Cmp2105; Na
3.12	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
2.86	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody

PDB Summary
PDB	5XF1
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	Glucagon
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	NNC0640
Protein Partners	-
PDB Resolution	3.19
Date	2017-05-24
D.O.I.	doi.org/10.1038/nature22363

Net Summary
I_min	1.49
Number of Linked Nodes	376
Number of Links	511
Number of Hubs	100
Number of Links mediated by Hubs	356
Number of Communities	11
Number of Nodes involved in Communities	148
Number of Links involved in Communities	236

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	262822
Length Of Smallest Path	3
Average Path Length	27.281
Length of Longest Path	45
Minimum Path Strength	1.145
Average Path Strength	5.52412
Maximum Path Strength	33.325
Minimum Path Correlation	0.7
Average Path Correlation	0.957015
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	57.7544
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.5331
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • FnI-like domain
SCOP2	Family Identifier	• G protein-coupled receptor-like • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	97V
PDB Residues	W:W:?2
Environment Details	Open EMBL-EBI Page
Code	97V
Name	4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Synonyms
Identifier
Formula	C29 H31 N7 O4 S
Molecular Weight	573.666
SMILES
PubChem	23549991
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	76
Total Aromatic Bonds	23


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>5XF1_Chain_R G A P Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S Q K I G D D L S V S T W L S D G A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N D N M G F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D E H A Q G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/β1/γ2	2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG8 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide		2.71	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	doi.org/10.1038/nature22363
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	doi.org/10.1038/nature22363
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	doi.org/10.1038/nature17414
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672	chim(NtGi1-Gs)/β1/γ2	3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RBT (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	LSN3556672		3.08	2022-04-13	doi.org/10.1073/pnas.2116506119
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7CZ5 (No Gprot)	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-		2.6	2020-11-18	doi.org/10.1038/s41467-020-18945-0
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		2.86	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/β1/γ2	3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIN (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-		3.1	2022-02-23	doi.org/10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VAB (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-		3.2	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/β1/γ2	3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RA3 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		3.24	2022-04-13	doi.org/10.1073/pnas.2116506119
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITL (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.23	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/β1/γ2	3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	8ITM (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-		3.13	2023-10-18	doi.org/10.1073/pnas.2306145120
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/β1/γ2	2.98	2021-08-04	doi.org/10.7554/eLife.68719
	7DTY (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-		2.98	2021-08-04	doi.org/10.7554/eLife.68719
	8YW4	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW4 (No Gprot)	B1	Peptide	Glucagon	GIP	Homo sapiens	Retatrutide	-		3.26	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/β1/γ2	3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	7D68 (No Gprot)	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-		3	2020-12-16	doi.org/10.1038/s41422-020-00442-0
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	8FU6 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		2.9	2023-04-12	doi.org/10.1016/j.cell.2023.02.028
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	doi.org/10.1038/nature12393
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon analogue	-	-	3	2018-01-17	doi.org/10.1038/nature25153
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7V35 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-		3.5	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	doi.org/10.1038/s41586-023-06420-x
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/β1/γ2	2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIT (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-		2.91	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/β1/γ2	3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIQ (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-		3.4	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/β1/γ2	2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	8JIU (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-		2.76	2023-09-13	doi.org/10.1073/pnas.2303696120
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/β1/γ2	3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6WHC (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-		3.4	2020-05-27	doi.org/10.1074/jbc.RA120.013793
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/β1/γ2	3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LMK (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.7	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gi1/β1/γ1	3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6LML (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-		3.9	2020-04-01	doi.org/10.1126/science.aaz5346
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/β1/γ2	3.1	2020-08-12	doi.org/10.1126/science.aba3373
	6WPW (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-		3.1	2020-08-12	doi.org/10.1126/science.aba3373
	8YW5	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW5 (No Gprot)	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Retatrutide	-		2.84	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	7D3S (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.9	2020-11-04	doi.org/10.1016/j.bbrc.2020.08.042
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WI9 (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		4.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/β1/γ2	2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4
	6WZG (No Gprot)	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-		2.3	2020-08-12	doi.org/10.1038/s41467-020-17791-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5XF1.zip

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