psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A25	R:R:G24	1.95	No	No	0	4	5
2	R:R:A25	R:R:P26	1.87	No	No	0	4	6
3	R:R:D30	R:R:Q27	2.61	No	No	0	5	5
4	R:R:V28	R:R:Y202	8.83	No	Yes	0	3	1
5	R:R:M29	R:R:Y202	5.99	No	Yes	0	5	1
6	R:R:M29	R:R:Q204	8.16	No	No	0	5	4
7	R:R:L32	R:R:P86	3.28	No	Yes	2	4	3
8	R:R:L32	R:R:Y202	9.38	No	Yes	2	4	1
9	R:R:F33	R:R:W36	4.01	No	Yes	0	4	6
10	R:R:F62	R:R:W36	4.01	Yes	Yes	0	7	6
11	R:R:K64	R:R:W36	2.32	No	Yes	0	4	6
12	R:R:W36	R:R:Y84	10.61	Yes	Yes	0	6	5
13	R:R:D41	R:R:K37	2.77	No	No	0	4	3
14	R:R:L38	R:R:W83	2.28	No	Yes	0	3	2
15	R:R:F62	R:R:Y39	4.13	Yes	Yes	2	7	6
16	R:R:S66	R:R:Y39	2.54	Yes	Yes	2	5	6
17	R:R:P82	R:R:Y39	5.56	Yes	Yes	2	8	6
18	R:R:W83	R:R:Y39	13.5	Yes	Yes	2	2	6
19	R:R:Y39	R:R:Y84	9.93	Yes	Yes	2	6	5
20	H:H:?7	R:R:Y39	5.23	Yes	Yes	2	0	6
21	R:R:C43	R:R:G40	1.96	Yes	No	2	9	4
22	R:R:F62	R:R:G40	6.02	Yes	No	2	7	4
23	R:R:Q42	R:R:W83	5.48	No	Yes	2	5	2
24	H:H:?7	R:R:Q42	15.43	Yes	No	2	0	5
25	R:R:C43	R:R:L47	3.17	Yes	No	2	9	5
26	R:R:C43	R:R:F62	5.59	Yes	Yes	2	9	7
27	R:R:C43	R:R:C67	7.28	Yes	No	2	9	9
28	R:R:F62	R:R:H44	4.53	Yes	No	0	7	2
29	H:H:?7	R:R:N46	24.5	Yes	No	0	0	5
30	R:R:L47	R:R:R60	10.93	No	No	0	5	4
31	R:R:C67	R:R:L47	4.76	No	No	2	9	5
32	R:R:L50	R:R:P51	4.93	No	No	0	3	2
33	R:R:L50	R:R:R60	2.43	No	No	0	3	4
34	R:R:P51	R:R:P52	1.95	No	No	0	2	1
35	R:R:P52	R:R:P53	1.95	No	Yes	0	1	3
36	R:R:P53	R:R:V57	1.77	Yes	Yes	7	3	3
37	R:R:D70	R:R:P53	3.22	No	Yes	7	4	3
38	H:H:?9	R:R:P53	2.93	Yes	Yes	0	0	3
39	R:R:G104	R:R:L56	1.71	No	No	0	9	2
40	R:R:D70	R:R:V57	4.38	No	Yes	7	4	3
41	R:R:P72	R:R:V57	1.77	No	Yes	0	1	3
42	R:R:C58	R:R:T71	1.69	No	Yes	2	9	7
43	R:R:C100	R:R:C58	7.28	No	No	2	9	9
44	R:R:C58	R:R:W106	16.98	No	Yes	2	9	9
45	H:H:?9	R:R:N59	31.85	Yes	No	0	0	4
46	R:R:D70	R:R:R60	14.29	No	No	0	4	4
47	R:R:T61	R:R:W106	3.64	No	Yes	0	6	9
48	R:R:D63	R:R:W68	7.82	Yes	Yes	2	9	9
49	R:R:D63	R:R:K98	11.06	Yes	Yes	2	9	8
50	R:R:D63	R:R:P114	3.22	Yes	Yes	2	9	5
51	R:R:D63	R:R:R116	14.29	Yes	Yes	2	9	6
52	R:R:S66	R:R:Y65	6.36	Yes	Yes	2	5	6
53	R:R:P82	R:R:Y65	11.13	Yes	Yes	2	8	6
54	R:R:Y65	R:R:Y84	3.97	Yes	Yes	2	6	5
55	R:R:L85	R:R:Y65	2.34	Yes	Yes	2	6	6
56	R:R:V96	R:R:Y65	3.79	Yes	Yes	2	7	6
57	R:R:R116	R:R:Y65	12.35	Yes	Yes	2	6	6
58	R:R:A118	R:R:Y65	4	No	Yes	2	5	6
59	R:R:C121	R:R:Y65	4.03	Yes	Yes	2	9	6
60	R:R:S66	R:R:W68	4.94	Yes	Yes	2	5	9
61	R:R:I79	R:R:S66	3.1	No	Yes	2	4	5
62	R:R:P82	R:R:S66	5.34	Yes	Yes	2	8	5
63	R:R:S66	R:R:V96	3.23	Yes	Yes	2	5	7
64	H:H:?7	R:R:C67	2.83	Yes	No	2	0	9
65	R:R:P69	R:R:W68	2.7	No	Yes	0	6	9
66	R:R:A77	R:R:W68	2.59	No	Yes	2	7	9
67	R:R:I79	R:R:W68	8.22	No	Yes	2	4	9
68	R:R:V96	R:R:W68	3.68	Yes	Yes	2	7	9
69	R:R:K98	R:R:W68	12.76	Yes	Yes	2	8	9
70	R:R:P72	R:R:T71	5.25	No	Yes	0	1	7
71	R:R:A77	R:R:T71	5.03	No	Yes	2	7	7
72	R:R:C100	R:R:T71	1.69	No	Yes	2	9	7
73	R:R:T71	R:R:W106	8.49	Yes	Yes	2	7	9
74	R:R:P72	R:R:T75	5.25	No	No	0	1	5
75	H:H:?14	R:R:A73	4.22	No	No	0	0	6
76	R:R:N74	R:R:R99	2.41	No	No	0	7	3
77	R:R:N74	R:R:P102	9.77	No	No	0	7	1
78	H:H:?14	R:R:N74	23.27	No	No	0	0	7
79	R:R:F97	R:R:T76	2.59	Yes	No	0	5	5
80	R:R:R99	R:R:T76	9.06	No	No	0	3	5
81	R:R:A77	R:R:W106	2.59	No	Yes	2	7	9
82	R:R:F97	R:R:N78	8.46	Yes	No	8	5	4
83	H:H:?12	R:R:N78	24.5	No	No	8	0	4
84	R:R:F95	R:R:S80	5.28	No	No	0	1	3
85	R:R:C81	R:R:P82	1.88	No	Yes	2	9	8
86	R:R:C81	R:R:V91	5.12	No	No	0	9	6
87	R:R:C121	R:R:C81	7.28	Yes	No	2	9	9
88	R:R:P82	R:R:Y84	9.74	Yes	Yes	2	8	5
89	R:R:L85	R:R:P82	4.93	Yes	Yes	2	6	8
90	R:R:C121	R:R:P82	1.88	Yes	Yes	2	9	8
91	R:R:W83	R:R:Y84	1.93	Yes	Yes	2	2	5
92	R:R:H88	R:R:W83	2.12	No	Yes	2	4	2
93	H:H:?7	R:R:W83	2.03	Yes	Yes	2	0	2
94	H:H:?8	R:R:W83	3.05	No	Yes	2	0	2
95	R:R:L85	R:R:Y84	3.52	Yes	Yes	2	6	5
96	R:R:L85	R:R:P86	3.28	Yes	Yes	2	6	3
97	R:R:L85	R:R:W87	9.11	Yes	Yes	2	6	3
98	R:R:C121	R:R:L85	1.59	Yes	Yes	2	9	6
99	R:R:P86	R:R:W87	14.86	Yes	Yes	2	3	3
100	R:R:P86	R:R:Y202	11.13	Yes	Yes	2	3	1
101	R:R:P86	R:R:W215	2.7	Yes	Yes	2	3	2
102	R:R:V91	R:R:W87	2.45	No	Yes	0	6	3
103	R:R:M123	R:R:W87	11.63	No	Yes	0	3	3
104	R:R:W215	R:R:W87	12.18	Yes	Yes	2	2	3
105	R:R:H88	R:R:H89	11.94	No	No	2	4	5
106	R:R:H88	R:R:Q92	4.95	No	No	2	4	1
107	R:R:H89	R:R:Q92	8.65	No	No	2	5	1
108	R:R:D218	R:R:K90	5.53	No	No	0	4	4
109	R:R:R94	R:R:V91	3.92	No	No	0	5	6
110	R:R:H93	R:R:R94	7.9	No	No	0	4	5
111	R:R:Q120	R:R:R94	24.53	No	No	0	5	5
112	R:R:R116	R:R:V96	3.92	Yes	Yes	2	6	7
113	R:R:A118	R:R:V96	1.7	No	Yes	2	5	7
114	R:R:C121	R:R:V96	1.71	Yes	Yes	2	9	7
115	R:R:D117	R:R:F97	4.78	No	Yes	0	7	5
116	R:R:F97	R:R:Q120	3.51	Yes	No	0	5	5
117	H:H:?12	R:R:F97	5.43	No	Yes	8	0	5
118	R:R:K98	R:R:W106	17.4	Yes	Yes	2	8	9
119	R:R:K98	R:R:P114	1.67	Yes	Yes	2	8	5
120	R:R:K98	R:R:R116	2.48	Yes	Yes	2	8	6
121	R:R:R99	R:R:V107	5.23	No	No	0	3	5
122	R:R:C100	R:R:W106	2.61	No	Yes	2	9	9
123	R:R:G101	R:R:P102	4.06	No	No	0	5	1
124	R:R:G101	R:R:V107	1.84	No	No	0	5	5
125	R:R:D103	R:R:P102	1.61	No	No	0	5	1
126	H:H:?9	R:R:Q105	7.12	Yes	No	0	0	5
127	R:R:G112	R:R:R108	4.5	No	No	0	6	1
128	R:R:G109	R:R:P110	4.06	No	No	2	4	3
129	R:R:G109	R:R:Q113	4.93	No	Yes	2	4	4
130	R:R:P110	R:R:Q113	6.32	No	Yes	2	3	4
131	R:R:Q113	R:R:R111	3.5	Yes	No	0	4	4
132	R:R:G112	R:R:Q113	1.64	No	Yes	0	6	4
133	R:R:P114	R:R:Q113	3.16	Yes	Yes	2	5	4
134	R:R:P114	R:R:R116	2.88	Yes	Yes	2	5	6
135	R:R:D117	R:R:S119	5.89	No	No	0	7	5
136	R:R:G125	R:R:M123	3.49	No	No	0	2	3
137	R:R:M123	R:R:S213	3.07	No	No	0	3	3
138	R:R:D124	R:R:W215	2.23	No	Yes	0	2	2
139	R:R:G125	R:R:T214	1.82	No	No	0	2	1
140	R:R:E127	R:R:Q204	7.65	No	No	0	1	4
141	R:R:E127	R:R:S211	8.62	No	No	0	1	4
142	R:R:E127	R:R:S213	4.31	No	No	0	1	3
143	R:R:I128	R:R:T214	3.04	No	No	0	2	1
144	R:R:E129	R:R:I206	5.47	No	No	9	1	4
145	R:R:D209	R:R:E129	16.89	No	No	0	4	1
146	R:R:E129	R:R:S211	4.31	No	No	9	1	4
147	R:R:V130	R:R:V134	3.21	No	No	0	1	2
148	R:R:A135	R:R:V130	3.39	No	No	0	3	1
149	R:R:Q131	R:R:V134	5.73	No	No	0	3	2
150	R:R:D209	R:R:Q131	7.83	No	No	0	4	3
151	R:R:E133	R:R:K132	6.75	No	No	0	2	2
152	R:R:K132	R:R:K205	2.87	No	No	0	2	4
153	R:R:A135	R:R:L210	3.15	No	Yes	0	3	4
154	R:R:M137	R:R:S140	3.07	No	No	11	4	4
155	R:R:F141	R:R:M137	7.46	Yes	No	11	6	4
156	R:R:F141	R:R:S140	5.28	Yes	No	11	6	4
157	R:R:F141	R:R:M144	2.49	Yes	No	0	6	6
158	R:R:F141	R:R:F383	19.29	Yes	No	0	6	5
159	R:R:D195	R:R:Q142	5.22	No	No	0	7	5
160	R:R:Q142	R:R:R199	3.5	No	No	0	5	4
161	R:R:V143	R:R:V147	1.6	No	No	0	4	5
162	R:R:F387	R:R:M144	4.98	No	No	0	5	6
163	R:R:Y145	R:R:Y149	6.95	Yes	Yes	5	7	8
164	R:R:V191	R:R:Y145	8.83	No	Yes	5	7	7
165	R:R:D195	R:R:Y145	6.9	No	Yes	0	7	7
166	R:R:L386	R:R:Y145	8.21	No	Yes	0	7	7
167	R:R:S150	R:R:T146	1.6	No	No	0	7	7
168	R:R:G148	R:R:S390	3.71	No	No	5	7	9
169	R:R:F391	R:R:G148	7.53	Yes	No	5	7	7
170	R:R:K187	R:R:Y149	4.78	Yes	Yes	0	8	8
171	R:R:V191	R:R:Y149	10.09	No	Yes	5	7	8
172	R:R:S390	R:R:Y149	3.82	No	Yes	5	9	8
173	R:R:L192	R:R:S150	4.5	No	No	0	7	7
174	R:R:F391	R:R:L151	2.44	Yes	No	0	7	5
175	R:R:L151	R:R:L394	4.15	No	Yes	0	5	5
176	R:R:G393	R:R:S152	3.71	Yes	No	0	9	9
177	R:R:L394	R:R:S152	4.5	Yes	No	0	5	9
178	R:R:G154	R:R:L153	1.71	No	Yes	0	4	6
179	R:R:L153	R:R:L157	4.15	Yes	No	1	6	3
180	R:R:A188	R:R:L153	3.15	No	Yes	0	8	6
181	R:R:A155	R:R:L394	3.15	No	Yes	0	6	5
182	R:R:A155	R:R:A397	1.79	No	No	0	6	8
183	R:R:F181	R:R:L156	3.65	Yes	Yes	1	8	8
184	R:R:F184	R:R:L156	2.44	Yes	Yes	1	8	8
185	R:R:L156	R:R:V185	4.47	Yes	No	1	8	8
186	R:R:G393	R:R:L156	1.71	Yes	Yes	1	9	8
187	R:R:A397	R:R:L156	3.15	No	Yes	0	8	8
188	R:R:F402	R:R:L158	4.87	No	No	0	9	5
189	R:R:A159	R:R:C401	3.61	No	Yes	0	9	9
190	R:R:A159	R:R:F402	2.77	No	No	0	9	9
191	R:R:A178	R:R:L160	1.58	No	No	0	7	6
192	R:R:F181	R:R:L160	3.65	Yes	No	0	8	6
193	R:R:C401	R:R:I162	1.64	Yes	No	0	9	8
194	R:R:L163	R:R:N174	9.61	No	Yes	0	8	9
195	R:R:C401	R:R:L163	4.76	Yes	No	0	9	8
196	R:R:G164	R:R:G165	2.11	No	No	0	3	3
197	R:R:L166	R:R:R414	2.43	No	Yes	0	7	5
198	R:R:E410	R:R:S167	2.87	No	No	6	8	8
199	R:R:R413	R:R:S167	2.64	No	No	6	7	8
200	R:R:R414	R:R:S167	5.27	Yes	No	6	5	8
201	R:R:C171	R:R:K168	11.32	No	No	1	7	8
202	R:R:K168	R:R:N174	9.79	No	Yes	1	8	9
203	R:R:H170	R:R:R261	7.9	No	No	0	7	5
204	R:R:C171	R:R:N174	9.45	No	Yes	1	7	9
205	R:R:R261	R:R:T172	6.47	No	No	0	5	7
206	R:R:H177	R:R:R173	2.26	Yes	Yes	1	9	9
207	R:R:R173	R:R:Y248	6.17	Yes	Yes	1	9	8
208	R:R:R173	R:R:Y343	3.09	Yes	Yes	1	9	7
209	R:R:L347	R:R:R173	8.5	Yes	Yes	1	9	9
210	R:R:N404	R:R:R173	6.03	Yes	Yes	1	9	9
211	R:R:E406	R:R:R173	10.47	Yes	Yes	1	9	9
212	R:R:H177	R:R:N174	2.55	Yes	Yes	1	9	9
213	R:R:I176	R:R:W241	2.35	Yes	Yes	1	9	9
214	R:R:I176	R:R:V244	3.07	Yes	No	1	9	8
215	R:R:E245	R:R:I176	6.83	Yes	Yes	1	9	9
216	R:R:I176	R:R:Y248	6.04	Yes	Yes	1	9	8
217	R:R:F181	R:R:H177	2.26	Yes	Yes	1	8	9
218	R:R:E245	R:R:H177	11.08	Yes	Yes	1	9	9
219	R:R:H177	R:R:L347	2.57	Yes	Yes	1	9	9
220	R:R:H177	R:R:Y400	11.98	Yes	Yes	1	9	8
221	R:R:N179	R:R:W241	14.69	No	Yes	1	8	9
222	R:R:N179	R:R:W272	10.17	No	Yes	1	8	9
223	R:R:L180	R:R:W241	2.28	Yes	Yes	1	9	9
224	R:R:E245	R:R:L180	5.3	Yes	Yes	1	9	9
225	R:R:L180	R:R:V396	2.98	Yes	Yes	0	9	9
226	R:R:L180	R:R:Y400	2.34	Yes	Yes	1	9	8
227	R:R:F181	R:R:V396	2.62	Yes	Yes	0	8	9
228	R:R:F181	R:R:Y400	2.06	Yes	Yes	1	8	8
229	R:R:C401	R:R:F181	2.79	Yes	Yes	0	9	8
230	R:R:A182	R:R:W272	2.59	No	Yes	0	4	9
231	R:R:A237	R:R:S183	1.71	No	No	0	7	9
232	R:R:N238	R:R:S183	7.45	No	No	0	9	9
233	R:R:S183	R:R:W272	2.47	No	Yes	0	9	9
234	R:R:F184	R:R:N238	25.37	Yes	No	0	8	9
235	R:R:F184	R:R:Q392	8.2	Yes	Yes	1	8	9
236	R:R:F184	R:R:G393	4.52	Yes	Yes	1	8	9
237	R:R:F184	R:R:V396	7.87	Yes	Yes	0	8	9
238	R:R:F230	R:R:L186	2.44	No	No	0	4	7
239	R:R:I235	R:R:K187	4.36	No	Yes	0	5	8
240	R:R:K187	R:R:N238	5.6	Yes	No	0	8	9
241	R:R:K187	R:R:Q392	4.07	Yes	Yes	0	8	9
242	R:R:M231	R:R:S190	4.6	No	No	0	6	5
243	R:R:M231	R:R:V191	3.04	No	No	0	6	7
244	R:R:A227	R:R:V193	3.39	No	No	0	6	5
245	R:R:A227	R:R:I194	3.25	No	No	0	6	6
246	R:R:C294	R:R:I194	1.64	No	No	0	9	6
247	R:R:A220	R:R:L197	3.15	No	No	0	6	4
248	R:R:G223	R:R:L197	1.71	No	No	0	3	4
249	R:R:C224	R:R:L197	3.17	No	No	0	9	4
250	R:R:L198	R:R:R201	13.36	No	No	0	6	4
251	R:R:C294	R:R:L198	3.17	No	No	0	9	6
252	R:R:R201	R:R:V212	6.54	No	No	0	4	3
253	R:R:L216	R:R:R201	3.64	No	No	0	2	4
254	R:R:S213	R:R:Y202	5.09	No	Yes	0	3	1
255	R:R:L210	R:R:S203	3	Yes	No	10	4	4
256	R:R:S203	R:R:V212	4.85	No	No	10	4	3
257	R:R:K205	R:R:L210	2.82	No	Yes	0	4	4
258	R:R:I206	R:R:S211	4.64	No	No	9	4	4
259	R:R:L210	R:R:V212	2.98	Yes	No	10	4	3
260	R:R:Q293	R:R:T214	9.92	No	No	0	4	1
261	R:R:A220	R:R:L216	3.15	No	No	0	6	2
262	R:R:G219	R:R:S217	1.86	No	No	0	3	4
263	R:R:A220	R:R:S217	1.71	No	No	0	6	4
264	R:R:R225	R:R:V221	2.62	Yes	No	0	8	4
265	R:R:C224	R:R:C294	5.46	No	No	0	9	9
266	R:R:C287	R:R:R225	4.18	No	Yes	4	3	8
267	R:R:N291	R:R:R225	12.05	No	Yes	0	6	8
268	R:R:R225	R:R:W295	9	Yes	Yes	4	8	9
269	R:R:F230	R:R:V226	2.62	No	No	0	4	4
270	R:R:A228	R:R:W295	2.59	No	Yes	0	5	9
271	R:R:A283	R:R:V229	3.39	No	No	0	5	6
272	R:R:V229	R:R:W295	3.68	No	Yes	0	6	9
273	R:R:I235	R:R:M231	2.92	No	No	0	5	6
274	R:R:Q232	R:R:W282	10.95	No	Yes	12	7	9
275	R:R:L307	R:R:Q232	11.98	No	No	12	7	7
276	R:R:W272	R:R:Y233	6.75	Yes	Yes	0	9	9
277	R:R:P275	R:R:Y233	4.17	Yes	Yes	0	9	9
278	R:R:M276	R:R:Y233	10.78	No	Yes	0	3	9
279	R:R:V279	R:R:Y233	3.79	No	Yes	0	6	9
280	R:R:A237	R:R:G234	1.95	No	No	0	7	5
281	R:R:C240	R:R:V236	1.71	Yes	Yes	3	6	6
282	R:R:P275	R:R:V236	5.3	Yes	Yes	3	9	6
283	R:R:V236	R:R:V279	3.21	Yes	No	0	6	6
284	R:R:P310	R:R:V236	5.3	No	Yes	3	9	6
285	R:R:V236	R:R:V311	4.81	Yes	No	0	6	8
286	R:R:A237	R:R:P275	1.87	No	Yes	0	7	9
287	R:R:V311	R:R:Y239	7.57	No	Yes	0	8	8
288	R:R:I315	R:R:Y239	4.84	No	Yes	0	7	8
289	R:R:L358	R:R:Y239	10.55	Yes	Yes	0	9	8
290	R:R:E362	R:R:Y239	6.73	No	Yes	0	8	8
291	R:R:C240	R:R:G271	1.96	Yes	No	0	6	9
292	R:R:A274	R:R:C240	1.81	No	Yes	3	4	6
293	R:R:C240	R:R:P275	5.65	Yes	Yes	3	6	9
294	R:R:V244	R:R:W241	8.58	No	Yes	1	8	9
295	R:R:L268	R:R:W241	10.25	No	Yes	0	5	9
296	R:R:G271	R:R:W241	8.44	No	Yes	0	9	9
297	R:R:W241	R:R:W272	19.68	Yes	Yes	1	9	9
298	R:R:I355	R:R:L242	2.85	Yes	No	0	8	9
299	R:R:L242	R:R:L358	4.15	No	Yes	0	9	9
300	R:R:L243	R:R:L247	2.77	No	Yes	0	8	7
301	R:R:I317	R:R:L243	2.85	No	No	0	6	8
302	R:R:L243	R:R:N318	10.98	No	No	0	8	9
303	R:R:F264	R:R:V244	2.62	Yes	No	1	6	8
304	R:R:E245	R:R:G246	1.64	Yes	Yes	1	9	9
305	R:R:E245	R:R:T351	2.82	Yes	Yes	1	9	9
306	R:R:E245	R:R:Y400	19.08	Yes	Yes	1	9	8
307	R:R:G246	R:R:I321	1.76	Yes	Yes	1	9	8
308	R:R:G246	R:R:T351	1.82	Yes	Yes	1	9	9
309	R:R:G246	R:R:I355	1.76	Yes	Yes	0	9	8
310	R:R:L247	R:R:N251	2.75	Yes	No	1	7	7
311	R:R:F264	R:R:L247	2.44	Yes	Yes	1	6	7
312	R:R:I321	R:R:L247	2.85	Yes	Yes	1	8	7
313	R:R:L252	R:R:Y248	4.69	No	Yes	1	8	8
314	R:R:E260	R:R:Y248	3.37	No	Yes	1	6	8
315	R:R:F264	R:R:Y248	5.16	Yes	Yes	1	6	8
316	R:R:L347	R:R:Y248	2.34	Yes	Yes	1	9	8
317	R:R:L249	R:R:L347	4.15	No	Yes	0	9	9
318	R:R:A348	R:R:L249	1.58	No	No	0	7	9
319	R:R:L249	R:R:T351	7.37	No	Yes	0	9	9
320	R:R:H250	R:R:R324	10.16	No	No	0	7	8
321	R:R:F263	R:R:N251	8.46	Yes	No	1	5	7
322	R:R:F264	R:R:N251	4.83	Yes	No	1	6	7
323	R:R:E260	R:R:L252	10.6	No	No	1	6	8
324	R:R:F263	R:R:L252	2.44	Yes	No	1	5	8
325	R:R:L253	R:R:L328	2.77	No	No	0	8	8
326	R:R:G254	R:R:L328	3.42	No	No	0	6	8
327	R:R:R261	R:R:S265	3.95	No	No	0	5	3
328	R:R:F263	R:R:F264	6.43	Yes	Yes	1	5	6
329	R:R:F263	R:R:Y267	3.09	Yes	No	0	5	7
330	R:R:L268	R:R:S265	3	No	No	0	5	3
331	R:R:L266	R:R:Y267	5.86	No	No	0	3	7
332	R:R:A274	R:R:I270	1.62	No	No	0	4	7
333	R:R:G273	R:R:P275	2.03	No	Yes	0	6	9
334	R:R:A274	R:R:P275	1.87	No	Yes	3	4	9
335	R:R:M276	R:R:V280	3.04	No	No	0	3	2
336	R:R:F278	R:R:F309	6.43	No	No	3	5	4
337	R:R:F278	R:R:P310	23.12	No	No	3	5	9
338	R:R:V279	R:R:V280	1.6	No	No	0	6	2
339	R:R:P281	R:R:V280	3.53	No	No	0	4	2
340	R:R:A283	R:R:W282	2.59	No	Yes	0	5	9
341	R:R:K286	R:R:W282	19.73	No	Yes	0	8	9
342	R:R:I306	R:R:W282	23.49	No	Yes	0	8	9
343	R:R:L307	R:R:W282	20.5	No	Yes	12	7	9
344	R:R:G302	R:R:K286	3.49	No	No	0	2	8
345	R:R:C287	R:R:L288	3.17	No	No	0	3	1
346	R:R:C287	R:R:W295	5.22	No	Yes	4	3	9
347	R:R:E290	R:R:V292	4.28	No	No	4	6	4
348	R:R:E290	R:R:S297	2.87	No	No	4	6	4
349	R:R:D299	R:R:E290	2.6	No	No	4	4	6
350	R:R:V292	R:R:W295	3.68	No	Yes	4	4	9
351	R:R:S297	R:R:V292	1.62	No	No	4	4	4
352	R:R:D299	R:R:S297	4.42	No	No	4	4	4
353	R:R:H372	R:R:N298	8.93	No	No	0	4	6
354	R:R:D370	R:R:N300	5.39	No	No	0	4	5
355	R:R:M301	R:R:W305	3.49	No	No	0	5	7
356	R:R:G302	R:R:I306	5.29	No	No	0	2	8
357	R:R:F303	R:R:L307	2.44	No	No	0	4	7
358	R:R:F303	R:R:R308	12.83	No	No	0	4	6
359	R:R:W304	R:R:W305	2.81	No	No	0	6	7
360	R:R:F312	R:R:W304	7.02	Yes	No	0	5	6
361	R:R:F312	R:R:R308	3.21	Yes	No	0	5	6
362	R:R:E362	R:R:R308	4.65	No	No	0	8	6
363	R:R:F309	R:R:P310	4.33	No	No	3	4	9
364	R:R:F312	R:R:V363	6.55	Yes	No	0	5	6
365	R:R:A366	R:R:F312	2.77	No	Yes	0	7	5
366	R:R:I317	R:R:L313	2.85	No	No	0	6	3
367	R:R:F319	R:R:I315	2.51	No	No	0	7	7
368	R:R:G359	R:R:I315	5.29	No	No	0	9	7
369	R:R:I317	R:R:I321	2.94	No	Yes	0	6	8
370	R:R:I355	R:R:N318	8.5	Yes	No	0	8	9
371	R:R:F320	R:R:R324	5.34	No	No	0	5	8
372	R:R:I321	R:R:I325	2.94	Yes	No	1	8	9
373	R:R:F322	R:R:V326	2.62	No	No	0	9	7
374	R:R:F322	R:R:L352	4.87	No	Yes	0	9	8
375	R:R:I325	R:R:L352	5.71	No	Yes	0	9	8
376	R:R:V326	R:R:V330	1.6	No	No	0	7	6
377	R:R:A335	R:R:K332	1.61	No	No	0	7	9
378	R:R:K332	R:R:Q337	17.63	No	No	0	9	7
379	R:R:K332	R:R:M338	2.88	No	Yes	0	9	5
380	R:R:L333	R:R:M338	4.24	No	Yes	0	7	5
381	R:R:H340	R:R:L333	2.57	No	No	0	5	7
382	R:R:Q337	R:R:R336	8.18	No	No	0	7	5
383	R:R:F345	R:R:M338	4.98	Yes	Yes	0	7	5
384	R:R:H339	R:R:H340	9.55	No	No	0	4	5
385	R:R:F345	R:R:H340	2.26	Yes	No	0	7	5
386	R:R:D342	R:R:Y343	3.45	No	Yes	1	7	7
387	R:R:D342	R:R:K344	6.91	No	No	1	7	6
388	R:R:K344	R:R:Y343	13.14	No	Yes	1	6	7
389	R:R:E406	R:R:Y343	4.49	Yes	Yes	1	9	7
390	R:R:F345	R:R:K349	9.93	Yes	No	1	7	9
391	R:R:F345	W:W:?2	4.14	Yes	Yes	1	7	0
392	R:R:K405	R:R:R346	9.9	No	Yes	1	6	8
393	R:R:E406	R:R:R346	6.98	Yes	Yes	1	9	8
394	R:R:R346	W:W:?2	1.65	Yes	Yes	1	8	0
395	R:R:L347	R:R:Y400	3.52	Yes	Yes	1	9	8
396	R:R:L347	W:W:?2	1.88	Yes	Yes	1	9	0
397	R:R:A348	R:R:L352	1.58	No	Yes	0	7	8
398	R:R:K349	W:W:?2	23.03	No	Yes	1	9	0
399	R:R:L399	R:R:S350	4.5	Yes	No	1	8	9
400	R:R:S350	R:R:Y400	7.63	No	Yes	1	9	8
401	R:R:S350	W:W:?2	10.22	No	Yes	1	9	0
402	R:R:T351	R:R:Y400	7.49	Yes	Yes	1	9	8
403	R:R:L352	W:W:?2	4.71	Yes	Yes	0	8	0
404	R:R:T353	W:W:?2	18.06	No	Yes	0	8	0
405	R:R:L354	R:R:L358	2.77	Yes	Yes	0	9	9
406	R:R:L354	R:R:V396	5.96	Yes	Yes	0	9	9
407	R:R:L354	R:R:Y400	3.52	Yes	Yes	0	9	8
408	R:R:I355	R:R:P356	3.39	Yes	No	0	8	9
409	R:R:L357	R:R:L395	2.77	No	No	0	9	6
410	R:R:L358	R:R:Q392	9.32	Yes	Yes	0	9	9
411	R:R:V360	R:R:V364	1.6	No	No	0	6	6
412	R:R:E362	R:R:H361	2.46	No	Yes	0	8	8
413	R:R:D385	R:R:H361	8.82	Yes	Yes	0	7	8
414	R:R:H361	R:R:L388	6.43	Yes	No	0	8	6
415	R:R:H361	R:R:S389	5.58	Yes	No	1	8	6
416	R:R:H361	R:R:Q392	3.71	Yes	Yes	1	8	9
417	R:R:F365	R:R:T369	2.59	No	No	0	7	7
418	R:R:F365	R:R:L382	3.65	No	No	0	7	5
419	R:R:D385	R:R:F365	11.94	Yes	No	0	7	7
420	R:R:F367	R:R:V368	6.55	No	No	0	5	5
421	R:R:T369	R:R:V368	1.59	No	No	0	7	5
422	R:R:K381	R:R:T369	9.01	No	No	0	7	7
423	R:R:D370	R:R:H372	2.52	No	No	0	4	4
424	R:R:E371	R:R:Q374	12.74	No	No	0	5	4
425	R:R:H372	R:R:R378	2.26	No	Yes	0	4	4
426	R:R:G375	R:R:Q374	1.64	No	No	0	2	4
427	R:R:L377	R:R:Q374	13.31	No	No	0	3	4
428	R:R:L377	R:R:T376	2.95	No	No	0	3	2
429	R:R:K381	R:R:R378	4.95	No	Yes	0	7	4
430	R:R:L382	R:R:R378	7.29	No	Yes	0	5	4
431	R:R:L382	R:R:L386	2.77	No	No	0	5	7
432	R:R:D385	R:R:F384	5.97	Yes	No	0	7	4
433	R:R:F387	R:R:F391	8.57	No	Yes	0	5	7
434	R:R:Q392	R:R:S389	2.89	Yes	No	1	9	6
435	R:R:F391	R:R:S390	3.96	Yes	No	5	7	9
436	R:R:G393	R:R:Q392	1.64	Yes	Yes	1	9	9
437	R:R:L394	R:R:V398	2.98	Yes	No	0	5	6
438	R:R:L399	R:R:V398	2.98	Yes	No	1	8	6
439	R:R:L403	R:R:V398	2.98	No	No	1	5	6
440	R:R:L399	R:R:L403	2.77	Yes	No	1	8	5
441	R:R:L399	W:W:?2	8.48	Yes	Yes	1	8	0
442	R:R:Y400	W:W:?2	1.6	Yes	Yes	1	8	0
443	R:R:L403	W:W:?2	2.83	No	Yes	1	5	0
444	R:R:E406	R:R:N404	2.63	Yes	Yes	1	9	9
445	R:R:N404	R:R:V407	4.43	Yes	No	0	9	9
446	R:R:N404	W:W:?2	10.28	Yes	Yes	1	9	0
447	R:R:K405	R:R:Q408	4.07	No	No	0	6	7
448	R:R:K405	W:W:?2	4.8	No	Yes	1	6	0
449	R:R:R412	R:R:S409	2.64	No	No	0	5	4
450	R:R:E410	R:R:R413	11.63	No	No	6	8	7
451	R:R:E410	R:R:R414	2.33	No	Yes	6	8	5
452	R:R:R413	R:R:R414	18.13	No	Yes	6	7	5
453	R:R:H416	R:R:W415	20.1	No	No	0	3	5
454	H:H:?7	H:H:?8	39.65	Yes	No	2	0	0
455	H:H:?10	H:H:?9	30.84	No	Yes	0	0	0
456	H:H:?10	H:H:?11	26.43	No	No	0	0	0
457	H:H:?12	H:H:?13	35.24	No	No	0	0	0
458	R:R:A314	R:R:N318	1.56	No	No	0	8	9
459	R:R:A25	R:R:D30	1.54	No	No	0	4	5
460	R:R:A118	R:R:Q122	1.52	No	No	0	5	3
461	R:R:A256	R:R:Q337	1.52	No	No	0	7	7
462	R:R:A373	R:R:E371	1.51	No	No	0	3	5
463	R:R:L153	R:R:V185	1.49	Yes	No	1	6	8
464	R:R:L157	R:R:V185	1.49	No	No	1	3	8
465	R:R:L216	R:R:V221	1.49	No	No	0	2	4
466	R:R:L288	R:R:V284	1.49	No	No	0	1	4
467	R:R:D385	R:R:V364	1.46	Yes	No	0	7	6
468	R:R:D195	R:R:T146	1.45	No	No	0	7	7
469	R:R:E55	R:R:V57	1.43	No	Yes	0	4	3
470	R:R:I162	R:R:L166	1.43	No	No	0	8	7
471	R:R:E55	R:R:T54	1.41	No	No	0	4	1
472	R:R:G109	R:R:W115	1.41	No	No	0	4	4
473	R:R:L253	R:R:M338	1.41	No	Yes	0	8	5
474	R:R:K344	R:R:L253	1.41	No	No	0	6	8
475	R:R:L329	R:R:M338	1.41	No	Yes	0	9	5
476	R:R:L49	R:R:L50	1.38	No	No	0	2	3
477	R:R:L166	R:R:L411	1.38	No	No	0	7	5
478	R:R:L313	R:R:L316	1.38	No	No	0	3	3
479	R:R:L354	R:R:L395	1.38	Yes	No	0	9	6
480	R:R:E371	R:R:K381	1.35	No	No	0	5	7
481	R:R:D208	R:R:D209	1.33	No	No	0	4	4
482	R:R:H250	R:R:I321	1.33	No	Yes	1	7	8
483	R:R:H250	R:R:I325	1.33	No	No	1	7	9
484	R:R:F230	R:R:S190	1.32	No	No	0	4	5
485	R:R:R378	R:R:S379	1.32	Yes	No	0	4	3
486	R:R:H45	R:R:L49	1.29	No	No	0	4	2
487	R:R:H170	R:R:L169	1.29	No	No	0	7	9
488	R:R:R346	R:R:T341	1.29	Yes	No	0	8	6
489	R:R:V134	R:R:Y138	1.26	No	No	0	2	5
490	R:R:F278	R:R:L277	1.22	No	No	0	5	4
491	R:R:L333	R:R:R334	1.21	No	No	0	7	7
492	R:R:K35	R:R:Y84	1.19	No	Yes	0	4	5
493	R:R:F31	R:R:Q27	1.17	No	No	0	4	5
494	R:R:Q408	R:R:R412	1.17	No	No	0	7	5
495	R:R:K90	R:R:W87	1.16	No	Yes	2	4	3
496	R:R:K90	R:R:W215	1.16	No	Yes	2	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W36	5.2375	4	0	6
2	R:R:Y39	6.815	6	2	6
3	R:R:C43	4.5	4	2	9
4	R:R:P53	2.4675	4	7	3
5	R:R:V57	2.3375	4	7	3
6	R:R:F62	4.856	5	2	7
7	R:R:D63	9.0975	4	2	9
8	R:R:Y65	5.99625	8	2	6
9	R:R:S66	4.25167	6	2	5
10	R:R:W68	6.10143	7	2	9
11	R:R:T71	4.43	5	2	7
12	R:R:P82	5.78	7	2	8
13	R:R:W83	4.34143	7	2	2
14	R:R:Y84	5.84143	7	2	5
15	R:R:L85	4.12833	6	2	6
16	R:R:P86	7.05	5	2	3
17	R:R:W87	8.565	6	2	3
18	R:R:V96	3.005	6	2	7
19	R:R:F97	4.954	5	8	5
20	R:R:K98	9.074	5	2	8
21	R:R:W106	8.61833	6	2	9
22	R:R:Q113	3.91	5	2	4
23	R:R:P114	2.7325	4	2	5
24	R:R:R116	7.184	5	2	6
25	R:R:C121	3.298	5	2	9
26	R:R:F141	8.63	4	11	6
27	R:R:Y145	7.7225	4	5	7
28	R:R:Y149	6.41	4	5	8
29	R:R:L153	2.625	4	1	6
30	R:R:L156	3.084	5	1	8
31	R:R:R173	6.08667	6	1	9
32	R:R:N174	7.85	4	1	9
33	R:R:I176	4.5725	4	1	9
34	R:R:H177	5.45	6	1	9
35	R:R:L180	3.225	4	1	9
36	R:R:F181	2.83833	6	1	8
37	R:R:F184	9.68	5	1	8
38	R:R:K187	4.7025	4	0	8
39	R:R:Y202	8.084	5	2	1
40	R:R:L210	2.9875	4	10	4
41	R:R:W215	4.5675	4	2	2
42	R:R:R225	6.9625	4	4	8
43	R:R:Y233	6.3725	4	0	9
44	R:R:V236	4.066	5	3	6
45	R:R:Y239	7.4225	4	0	8
46	R:R:C240	2.7825	4	3	6
47	R:R:W241	9.46714	7	1	9
48	R:R:E245	7.79167	6	1	9
49	R:R:G246	1.745	4	1	9
50	R:R:L247	2.7025	4	1	7
51	R:R:Y248	4.62833	6	1	8
52	R:R:F263	5.105	4	1	5
53	R:R:F264	4.296	5	1	6
54	R:R:W272	8.332	5	1	9
55	R:R:P275	3.48167	6	3	9
56	R:R:W282	15.452	5	12	9
57	R:R:W295	4.834	5	4	9
58	R:R:F312	4.8875	4	0	5
59	R:R:I321	2.364	5	1	8
60	R:R:M338	2.984	5	0	5
61	R:R:Y343	6.0425	4	1	7
62	R:R:F345	5.3275	4	1	7
63	R:R:R346	4.955	4	1	8
64	R:R:L347	3.82667	6	1	9
65	R:R:T351	4.875	4	1	9
66	R:R:L352	4.2175	4	0	8
67	R:R:L354	3.4075	4	0	9
68	R:R:I355	4.125	4	0	8
69	R:R:L358	6.6975	4	0	9
70	R:R:H361	5.4	5	1	8
71	R:R:R378	3.955	4	0	4
72	R:R:D385	7.0475	4	0	7
73	R:R:F391	5.625	4	5	7
74	R:R:Q392	4.97167	6	1	9
75	R:R:G393	2.895	4	1	9
76	R:R:L394	3.695	4	0	5
77	R:R:V396	4.8575	4	0	9
78	R:R:L399	4.6825	4	1	8
79	R:R:Y400	6.58	9	1	8
80	R:R:C401	3.2	4	0	9
81	R:R:N404	5.8425	4	1	9
82	R:R:E406	6.1425	4	1	9
83	R:R:R414	7.04	4	6	5
84	W:W:?2	7.64	12	1	0
85	H:H:?7	14.945	6	2	0
86	H:H:?9	18.185	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P86	R:R:Y202	47.3408	11.13	Yes	Yes	2	3	1
2	R:R:L85	R:R:Y84	36.0799	3.52	Yes	Yes	2	6	5
3	R:R:L85	R:R:P86	47.1438	3.28	Yes	Yes	2	6	3
4	R:R:F62	R:R:Y39	16.2391	4.13	Yes	Yes	2	7	6
5	R:R:Y39	R:R:Y84	15.8603	9.93	Yes	Yes	2	6	5
6	R:R:P82	R:R:Y39	16.2973	5.56	Yes	Yes	2	8	6
7	R:R:L85	R:R:P82	23.5554	4.93	Yes	Yes	2	6	8
8	R:R:W83	R:R:Y84	10.6238	1.93	Yes	Yes	2	2	5
9	R:R:L85	R:R:Y65	27.4336	2.34	Yes	Yes	2	6	6
10	H:H:?7	R:R:Y39	15.3817	5.23	Yes	Yes	2	0	6
11	R:R:C43	R:R:F62	20.2743	5.59	Yes	Yes	2	9	7
12	R:R:C43	R:R:L47	18.9859	3.17	Yes	No	2	9	5
13	R:R:C67	R:R:L47	19.0102	4.76	No	No	2	9	5
14	H:H:?7	R:R:C67	20.3123	2.83	Yes	No	2	0	9
15	R:R:L47	R:R:R60	35.4068	10.93	No	No	0	5	4
16	R:R:L50	R:R:R60	12.7381	2.43	No	No	0	3	4
17	R:R:D70	R:R:P53	17.6064	3.22	No	Yes	7	4	3
18	R:R:D70	R:R:R60	20.2414	14.29	No	No	0	4	4
19	R:R:P53	R:R:V57	14.7112	1.77	Yes	Yes	7	3	3
20	R:R:P72	R:R:V57	21.1109	1.77	No	Yes	0	1	3
21	R:R:P72	R:R:T71	25.3325	5.25	No	Yes	0	1	7
22	R:R:A77	R:R:T71	21.982	5.03	No	Yes	2	7	7
23	R:R:A77	R:R:W68	23.8102	2.59	No	Yes	2	7	9
24	R:R:S66	R:R:W68	13.8594	4.94	Yes	Yes	2	5	9
25	R:R:V96	R:R:W68	13.5895	3.68	Yes	Yes	2	7	9
26	R:R:R116	R:R:Y65	12.3629	12.35	Yes	Yes	2	6	6
27	H:H:?9	R:R:P53	23.0652	2.93	Yes	Yes	0	0	3
28	R:R:M123	R:R:S213	52.2977	3.07	No	No	0	3	3
29	R:R:S213	R:R:Y202	47.4329	5.09	No	Yes	0	3	1
30	R:R:E127	R:R:S213	99.6622	4.31	No	No	0	1	3
31	R:R:E127	R:R:S211	100	8.62	No	No	0	1	4
32	R:R:E129	R:R:S211	99.6956	4.31	No	No	9	1	4
33	R:R:D209	R:R:E129	99.842	16.89	No	No	0	4	1
34	R:R:V130	R:R:V134	99.5584	3.21	No	No	0	1	2
35	R:R:Q131	R:R:V134	99.6749	5.73	No	No	0	3	2
36	R:R:D209	R:R:Q131	99.7316	7.83	No	No	0	4	3
37	R:R:A135	R:R:V130	99.4986	3.39	No	No	0	3	1
38	R:R:A135	R:R:L210	99.4379	3.15	No	Yes	0	3	4
39	R:R:K187	R:R:Q392	10.5524	4.07	Yes	Yes	0	8	9
40	R:R:H361	R:R:Q392	35.3202	3.71	Yes	Yes	1	8	9
41	R:R:E362	R:R:H361	40.1176	2.46	No	Yes	0	8	8
42	R:R:E362	R:R:R308	95.2193	4.65	No	No	0	8	6
43	R:R:F303	R:R:R308	95.9709	12.83	No	No	0	4	6
44	R:R:F303	R:R:L307	96.0742	2.44	No	No	0	4	7
45	R:R:L307	R:R:W282	96.0007	20.5	No	Yes	12	7	9
46	R:R:A283	R:R:W282	96.769	2.59	No	Yes	0	5	9
47	R:R:A283	R:R:V229	96.8642	3.39	No	No	0	5	6
48	R:R:V229	R:R:W295	96.9584	3.68	No	Yes	0	6	9
49	R:R:R225	R:R:W295	97.0394	9	Yes	Yes	4	8	9
50	R:R:R225	R:R:V221	98.0097	2.62	Yes	No	0	8	4
51	R:R:L216	R:R:V221	98.0908	1.49	No	No	0	2	4
52	R:R:L216	R:R:R201	98.3551	3.64	No	No	0	2	4
53	R:R:R201	R:R:V212	99.052	6.54	No	No	0	4	3
54	R:R:L210	R:R:V212	98.9254	2.98	Yes	No	10	4	3
55	R:R:F184	R:R:Q392	17.2995	8.2	Yes	Yes	1	8	9
56	R:R:F181	R:R:L156	10.9981	3.65	Yes	Yes	1	8	8
57	R:R:L354	R:R:L358	38.9645	2.77	Yes	Yes	0	9	9
58	R:R:L358	R:R:Y239	44.1437	10.55	Yes	Yes	0	9	8
59	R:R:E362	R:R:Y239	55.6168	6.73	No	Yes	0	8	8
60	R:R:L354	R:R:Y400	30.8561	3.52	Yes	Yes	0	9	8
61	R:R:C401	R:R:F181	19.739	2.79	Yes	Yes	0	9	8
62	R:R:C401	R:R:I162	11.5951	1.64	Yes	No	0	9	8
63	R:R:V236	R:R:V311	11.5637	4.81	Yes	No	0	6	8
64	R:R:V311	R:R:Y239	11.9263	7.57	No	Yes	0	8	8
65	R:R:Y400	W:W:?2	13.6598	1.6	Yes	Yes	1	8	0
66	R:R:M123	R:R:W87	51.9229	11.63	No	Yes	0	3	3
67	R:R:L85	R:R:W87	47.6694	9.11	Yes	Yes	2	6	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H177	R:R:R173	2.26	1	Yes	Yes	9	9	2	2
R:R:R173	R:R:Y248	6.17	1	Yes	Yes	9	8	2	2
R:R:L347	R:R:R173	8.5	1	Yes	Yes	9	9	1	2
R:R:N404	R:R:R173	6.03	1	Yes	Yes	9	9	1	2
R:R:E406	R:R:R173	10.47	1	Yes	Yes	9	9	2	2
R:R:F181	R:R:H177	2.26	1	Yes	Yes	8	9	2	2
R:R:E245	R:R:H177	11.08	1	Yes	Yes	9	9	2	2
R:R:H177	R:R:L347	2.57	1	Yes	Yes	9	9	2	1
R:R:H177	R:R:Y400	11.98	1	Yes	Yes	9	8	2	1
R:R:E245	R:R:L180	5.3	1	Yes	Yes	9	9	2	2
R:R:L180	R:R:Y400	2.34	1	Yes	Yes	9	8	2	1
R:R:F181	R:R:Y400	2.06	1	Yes	Yes	8	8	2	1
R:R:E245	R:R:T351	2.82	1	Yes	Yes	9	9	2	2
R:R:E245	R:R:Y400	19.08	1	Yes	Yes	9	8	2	1
R:R:L347	R:R:Y248	2.34	1	Yes	Yes	9	8	1	2
R:R:L249	R:R:L347	4.15	0	No	Yes	9	9	2	1
R:R:A348	R:R:L249	1.58	0	No	No	7	9	2	2
R:R:L249	R:R:T351	7.37	0	No	Yes	9	9	2	2
R:R:F322	R:R:L352	4.87	0	No	Yes	9	8	2	1
R:R:I325	R:R:L352	5.71	1	No	Yes	9	8	2	1
R:R:F345	R:R:M338	4.98	1	Yes	Yes	7	5	1	2
R:R:F345	R:R:H340	2.26	1	Yes	No	7	5	1	2
R:R:F345	R:R:K349	9.93	1	Yes	No	7	9	1	1
R:R:F345	W:W:?2	4.14	1	Yes	Yes	7	0	1	0
R:R:K405	R:R:R346	9.9	1	No	Yes	6	8	1	1
R:R:E406	R:R:R346	6.98	1	Yes	Yes	9	8	2	1
R:R:R346	W:W:?2	1.65	1	Yes	Yes	8	0	1	0
R:R:L347	R:R:Y400	3.52	1	Yes	Yes	9	8	1	1
R:R:L347	W:W:?2	1.88	1	Yes	Yes	9	0	1	0
R:R:A348	R:R:L352	1.58	0	No	Yes	7	8	2	1
R:R:K349	W:W:?2	23.03	1	No	Yes	9	0	1	0
R:R:L399	R:R:S350	4.5	1	Yes	No	8	9	1	1
R:R:S350	R:R:Y400	7.63	1	No	Yes	9	8	1	1
R:R:S350	W:W:?2	10.22	1	No	Yes	9	0	1	0
R:R:T351	R:R:Y400	7.49	1	Yes	Yes	9	8	2	1
R:R:L352	W:W:?2	4.71	0	Yes	Yes	8	0	1	0
R:R:T353	W:W:?2	18.06	0	No	Yes	8	0	1	0
R:R:L354	R:R:Y400	3.52	0	Yes	Yes	9	8	2	1
R:R:L399	R:R:V398	2.98	1	Yes	No	8	6	1	2
R:R:L403	R:R:V398	2.98	1	No	No	5	6	1	2
R:R:L399	R:R:L403	2.77	1	Yes	No	8	5	1	1
R:R:L399	W:W:?2	8.48	1	Yes	Yes	8	0	1	0
R:R:Y400	W:W:?2	1.6	1	Yes	Yes	8	0	1	0
R:R:L403	W:W:?2	2.83	1	No	Yes	5	0	1	0
R:R:E406	R:R:N404	2.63	1	Yes	Yes	9	9	2	1
R:R:N404	R:R:V407	4.43	1	Yes	No	9	9	1	2
R:R:N404	W:W:?2	10.28	1	Yes	Yes	9	0	1	0
R:R:K405	R:R:Q408	4.07	1	No	No	6	7	1	2
R:R:K405	W:W:?2	4.8	1	No	Yes	6	0	1	0
R:R:R346	R:R:T341	1.29	1	Yes	No	8	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
66.67	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
66.67	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
64.29	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
57.14	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
53.85	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
50.00	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
36.84	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
29.41	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
26.67	Consensus	gi_gaba	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
25.00	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
23.53	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
20.00	Single	7EB2	rac-BHFF	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
20.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
20.00	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
20.00	Consensus	gabab_on	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
20.00	Consensus	gi_class-c	Other Ligand	gi_mglu gi_gaba
18.18	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
17.65	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
17.39	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
16.67	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
16.67	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
16.67	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
15.00	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
15.00	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	4PXF	Octyl Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
14.29	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
14.29	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.29	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
13.64	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.33	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
13.04	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
13.04	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
10.53	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
9.09	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.70	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.33	Single	7DUR	PubChem 156022738	7DUR-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
7.69	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
6.67	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
6.25	Single	3VG9	Antibody	3VG9-A_2A-ZM241385-Antibody
5.88	Single	3VGA	Antibody	3VGA-A_2A-ZM241385-Antibody
5.56	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
4.76	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
4.55	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
4.55	Consensus	ccr7_off_allo	Other Ligand	6QZH-CCR7-HY-133073; Na
4.35	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2

PDB Summary
PDB	5XF1
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	Glucagon
Species	Homo sapiens
Ligand	-
Other Ligand(s)	NNC0640
Protein Partners	-
PDB Resolution	3.19
Date	2017-05-24
D.O.I.	10.1038/nature22363

Net Summary
I_min	1.58
Number of Linked Nodes	377
Number of Links	496
Number of Hubs	86
Number of Links mediated by Hubs	308
Number of Communities	12
Number of Nodes involved in Communities	134
Number of Links involved in Communities	213

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	269658
Length Of Smallest Path	3
Average Path Length	30.212
Length of Longest Path	48
Minimum Path Strength	1.335
Average Path Strength	5.78732
Maximum Path Strength	32.075
Minimum Path Correlation	0.7
Average Path Correlation	0.957296
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.17391
Average % Of Corr. Nodes	53.8738
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1813
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	97V
PDB Residues	W:W:?2
Environment Details	Open EMBL-EBI Page
Code	97V
Name	4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Synonyms
Identifier	4-[[(4-cyclohexylphenyl)-[(3-methylsulfonylphenyl)carbamoyl]amino]methyl]-~{N}-(1~{H}-1,2,3,4-tetrazol-5-yl)benzamide
Formula	C29 H31 N7 O4 S
Molecular Weight	573.666
SMILES	CS(=O)(=O)c1cccc(c1)NC(=O)N(Cc2ccc(cc2)C(=O)Nc3[nH]nnn3)c4ccc(cc4)C5CCCCC5
PubChem	23549991
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	76
Total Aromatic Bonds	23


Code	NAG
PDB Residues	H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11 H:H:?12 H:H:?13 H:H:?14
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P47871
Sequence	>5XF1_Chain_R G A P Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L S K L H C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S Q K I G D D L S V S T W L S D G A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L A E R S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E N V Q C W T S N D N M G F W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A R Q M H H T D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D E H A Q G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E V Q S E L R R R W H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7CZ5	B1	Peptide	Glucagon	GHRH	Homo sapiens	Somatoliberin	-	Gs/&β;1/&γ;2	2.6	2020-11-18	10.1038/s41467-020-18945-0
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.6	2022-04-06	10.1073/pnas.2106606118
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/&β;1/&γ;2	3.29	2021-10-20	10.1073/pnas.2106606118
	7DTY	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	Gs/&β;1/&γ;2	2.98	2021-08-04	10.7554/eLife.68719
	7FIN	B1	Peptide	Glucagon	GIP	Homo sapiens	Peptide-20; GGL	-	Gs/&β;1/&γ;2	3.1	2022-02-23	10.1038/s41467-022-28683-0
	7FIY	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	-	Gs/&β;1/&γ;2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7RA3	B1	Peptide	Glucagon	GIP	Homo sapiens	GIP	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.24	2022-04-13	10.1073/pnas.2116506119
	7RBT	B1	Peptide	Glucagon	GIP	Homo sapiens	Tirzepatide	PubChem 163183774	chim(NtGi1-Gs)/&β;1/&γ;2	3.08	2022-04-13	10.1073/pnas.2116506119
	7VAB	B1	Peptide	Glucagon	GIP	Homo sapiens	Non-Acylated Tirzepatide	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.2	2022-03-02	10.1038/s41467-022-28683-0
	8ITL	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/&β;1/&γ;2	3.23	2023-10-18	10.1073/pnas.2306145120
	8ITM	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/&β;1/&γ;2	3.13	2023-10-18	10.1073/pnas.2306145120
	8WA3	B1	Peptide	Glucagon	GIP	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.86	2024-03-06	10.1038/s41421-024-00649-0
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/&β;1/&γ;2	4.1	2017-05-24	10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/&β;1/&γ;2	3.3	2018-02-21	10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/&β;1/&γ;2	3	2020-01-08	10.1038/s41586-019-1902-z
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/&β;1/&γ;2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/&β;1/&γ;2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/&β;1/&γ;2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/&β;1/&γ;2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.1	2020-11-18	10.1073/pnas.2014879117
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/&β;1/&γ;2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/&β;1/&γ;2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/&β;1/&γ;2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/&β;1/&γ;2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/&β;1/&γ;2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/&β;1/&γ;2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/&β;1/&γ;2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/&β;1/&γ;2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/&β;1/&γ;2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/&β;1/&γ;2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/&β;1/&γ;2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/&β;1/&γ;2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/&β;1/&γ;2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/&β;1/&γ;2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/&β;1/&γ;2	3	2022-03-02	10.1038/s41467-022-28683-0
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/&β;1/&γ;2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/&β;1/&γ;2	3.09	2022-06-29	10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.46	2023-11-08	10.1073/pnas.2303696120
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	7D68	B1	Peptide	Glucagon	GLP-2	Homo sapiens	GLP-2	-	Gs/&β;1/&γ;2	3	2020-12-16	10.1038/s41422-020-00442-0
	4L6R	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	-	3.3	2013-07-24	10.1038/nature12393
	5EE7	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	MK0893	-	2.5	2016-04-20	10.1038/nature17414
	5XEZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3	2017-05-24	10.1038/nature22363
	5XF1	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	NNC0640	-	3.19	2017-05-24	10.1038/nature22363
	5YQZ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon analogue	-	-	3	2018-01-17	10.1038/nature25153
	6LMK	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Gs/&β;1/&γ;2	3.7	2020-04-01	10.1126/science.aaz5346
	6LML	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	-	3.9	2020-04-01	10.1126/science.aaz5346
	6WHC	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glu16 analog of GCG	-	Gs/&β;1/&γ;2	3.4	2020-05-27	10.1074/jbc.RA120.013793
	6WPW	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/&β;1/&γ;2	3.1	2020-08-12	10.1126/science.aba3373
	7V35	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-20	-	Gs/&β;1/&γ;2	3.5	2022-03-02	10.1038/s41467-022-28683-0
	8FU6	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon derivative ZP3780	-	Gs/&β;1/&γ;2	2.9	2023-04-12	10.1016/j.cell.2023.02.028
	8JIQ	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Peptide-15	-	Gs/&β;1/&γ;2	3.4	2023-09-13	10.1073/pnas.2303696120
	8JIT	B1	Peptide	Glucagon	Glucagon	Homo sapiens	MEDI0382	-	Gs/&β;1/&γ;2	2.91	2023-09-06	10.1073/pnas.2303696120
	8JIU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	SAR425899	-	Gs/&β;1/&γ;2	2.76	2023-09-13	10.1073/pnas.2303696120
	8JRU	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	-	Arrestin2	3.5	2023-08-16	10.1038/s41586-023-06420-x
	8JRV	B1	Peptide	Glucagon	Glucagon	Homo sapiens	Glucagon	-	Arrestin2	3.3	2023-08-16	10.1038/s41586-023-06420-x
	8WG8	B1	Peptide	Glucagon	Glucagon	Homo sapiens	-	Peptide	chim(NtGi1-Gs)/&β;1/&γ;2	2.71	2024-03-06	10.1038/s41421-024-00649-0
	6WI9	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/&β;1/&γ;2	4.3	2020-08-12	10.1038/s41467-020-17791-4
	6WZG	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/&β;1/&γ;2	2.3	2020-08-12	10.1038/s41467-020-17791-4
	7D3S	B1	Peptide	Glucagon	Secretin	Homo sapiens	Secretin	-	Gs/&β;1/&γ;2	2.9	2020-11-04	10.1016/j.bbrc.2020.08.042

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