| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5VEX | B1 | Peptide | Glucagon | GLP-1 | Homo Sapiens | - | NNC0640 | - | 3 | 2017-05-17 | doi.org/10.1038/nature22378 |
|
A 2D representation of the interactions of 97V in 5VEX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:N406 | R:R:R176 | 3.62 | 0 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:F324 | R:R:L354 | 7.31 | 3 | Yes | No | 9 | 8 | 2 | 1 | | R:R:L354 | R:R:V327 | 5.96 | 0 | No | No | 8 | 9 | 1 | 2 | | R:R:F347 | R:R:L335 | 4.87 | 8 | Yes | No | 7 | 8 | 1 | 2 | | R:R:F347 | R:R:M340 | 3.73 | 8 | Yes | No | 7 | 5 | 1 | 2 | | R:R:F347 | R:R:K342 | 13.65 | 8 | Yes | No | 7 | 5 | 1 | 2 | | R:R:F347 | R:R:K351 | 11.17 | 8 | Yes | No | 7 | 8 | 1 | 1 | | R:R:F347 | W:W:?1 | 3.32 | 8 | Yes | Yes | 7 | 0 | 1 | 0 | | R:R:N407 | R:R:R348 | 15.67 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:E408 | R:R:R348 | 10.47 | 0 | No | Yes | 9 | 8 | 2 | 1 | | R:R:R348 | W:W:?1 | 8.27 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:K351 | W:W:?1 | 25.91 | 8 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L401 | R:R:S352 | 6.01 | 0 | No | No | 8 | 9 | 2 | 1 | | R:R:S352 | R:R:Y402 | 5.09 | 0 | No | Yes | 9 | 8 | 1 | 2 | | R:R:S352 | W:W:?1 | 8.17 | 0 | No | Yes | 9 | 0 | 1 | 0 | | R:R:L354 | W:W:?1 | 4.71 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:T355 | W:W:?1 | 19.06 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:V405 | W:W:?1 | 10.14 | 0 | No | Yes | 6 | 0 | 1 | 0 | | R:R:E408 | R:R:N406 | 11.83 | 0 | No | Yes | 9 | 9 | 2 | 1 | | R:R:N406 | R:R:V409 | 7.39 | 0 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:N406 | W:W:?1 | 6.54 | 0 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:R348 | R:R:T343 | 2.59 | 0 | Yes | No | 8 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 10.77 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 22.00 | | Average Links Mediated by Hubs In Shell | 20.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5XEZ | B1 | Peptide | Glucagon | Glucagon | Homo Sapiens | - | NNC0640 | - | 3 | 2017-05-24 | doi.org/10.1038/nature22363 |
|
A 2D representation of the interactions of 97V in 5XEZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:R173 | R:R:Y343 | 5.14 | 1 | Yes | Yes | 9 | 7 | 2 | 2 | | R:R:N404 | R:R:R173 | 6.03 | 0 | No | Yes | 9 | 9 | 1 | 2 | | R:R:F345 | R:R:L329 | 8.53 | 1 | Yes | No | 7 | 9 | 1 | 2 | | R:R:L333 | R:R:M338 | 4.24 | 1 | Yes | No | 7 | 5 | 2 | 2 | | R:R:F345 | R:R:L333 | 3.65 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:F345 | R:R:M338 | 3.73 | 1 | Yes | No | 7 | 5 | 1 | 2 | | R:R:R346 | R:R:Y343 | 4.12 | 0 | No | Yes | 8 | 7 | 1 | 2 | | R:R:F345 | W:W:?3 | 7.46 | 1 | Yes | Yes | 7 | 0 | 1 | 0 | | R:R:K405 | R:R:R346 | 16.09 | 0 | No | No | 6 | 8 | 2 | 1 | | R:R:R346 | W:W:?3 | 3.31 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:K349 | W:W:?3 | 25.91 | 0 | No | Yes | 9 | 0 | 1 | 0 | | R:R:L399 | R:R:S350 | 3 | 1 | No | No | 8 | 9 | 1 | 1 | | R:R:S350 | R:R:Y400 | 7.63 | 1 | No | Yes | 9 | 8 | 1 | 2 | | R:R:S350 | W:W:?3 | 11.24 | 1 | No | Yes | 9 | 0 | 1 | 0 | | R:R:T353 | W:W:?3 | 20.06 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L357 | W:W:?3 | 2.83 | 0 | No | Yes | 9 | 0 | 1 | 0 | | R:R:L403 | R:R:V398 | 2.98 | 1 | No | No | 5 | 6 | 1 | 2 | | R:R:L399 | R:R:L403 | 4.15 | 1 | No | No | 8 | 5 | 1 | 1 | | R:R:L399 | W:W:?3 | 9.42 | 1 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L403 | W:W:?3 | 2.83 | 1 | No | Yes | 5 | 0 | 1 | 0 | | R:R:N404 | R:R:V407 | 5.91 | 0 | No | No | 9 | 9 | 1 | 2 | | R:R:N404 | W:W:?3 | 9.34 | 0 | No | Yes | 9 | 0 | 1 | 0 | | R:R:L395 | W:W:?3 | 1.88 | 0 | No | Yes | 6 | 0 | 1 | 0 | |
| Statistics | Value |
|---|
| Average Number Of Links | 10.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 9.43 | | Average Nodes In Shell | 20.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 23.00 | | Average Links Mediated by Hubs In Shell | 18.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5XF1 | B1 | Peptide | Glucagon | Glucagon | Homo Sapiens | - | NNC0640 | - | 3.19 | 2017-05-24 | doi.org/10.1038/nature22363 |
|
A 2D representation of the interactions of 97V in 5XF1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:H177 | R:R:R173 | 2.26 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | | R:R:R173 | R:R:Y248 | 6.17 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | R:R:L347 | R:R:R173 | 8.5 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | | R:R:N404 | R:R:R173 | 6.03 | 0 | No | Yes | 9 | 9 | 1 | 2 | | R:R:F181 | R:R:H177 | 2.26 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:E245 | R:R:H177 | 11.08 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | | R:R:H177 | R:R:L347 | 2.57 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | | R:R:H177 | R:R:Y400 | 11.98 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:E245 | R:R:L180 | 5.3 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | | R:R:L180 | R:R:Y400 | 2.34 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:F181 | R:R:Y400 | 2.06 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:E245 | R:R:T351 | 2.82 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | | R:R:E245 | R:R:Y400 | 19.08 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:L347 | R:R:Y248 | 2.34 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | | R:R:L249 | R:R:L347 | 4.15 | 0 | No | Yes | 9 | 9 | 2 | 1 | | R:R:A348 | R:R:L249 | 1.58 | 0 | No | No | 7 | 9 | 2 | 2 | | R:R:L249 | R:R:T351 | 7.37 | 0 | No | Yes | 9 | 9 | 2 | 2 | | R:R:F322 | R:R:L352 | 2.44 | 0 | No | Yes | 9 | 8 | 2 | 1 | | R:R:I325 | R:R:L352 | 2.85 | 0 | No | Yes | 9 | 8 | 2 | 1 | | R:R:F345 | R:R:L329 | 4.87 | 1 | Yes | No | 7 | 9 | 1 | 2 | | R:R:L333 | R:R:M338 | 4.24 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | R:R:F345 | R:R:L333 | 2.44 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:F345 | R:R:M338 | 7.46 | 1 | Yes | Yes | 7 | 5 | 1 | 2 | | R:R:F345 | R:R:K349 | 2.48 | 1 | Yes | No | 7 | 9 | 1 | 1 | | R:R:F345 | W:W:?2 | 4.97 | 1 | Yes | Yes | 7 | 0 | 1 | 0 | | R:R:K405 | R:R:R346 | 6.19 | 11 | No | No | 6 | 8 | 2 | 1 | | R:R:R346 | W:W:?2 | 1.65 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L347 | R:R:Y400 | 3.52 | 1 | Yes | Yes | 9 | 8 | 1 | 1 | | R:R:L347 | W:W:?2 | 1.88 | 1 | Yes | Yes | 9 | 0 | 1 | 0 | | R:R:A348 | R:R:L352 | 3.15 | 0 | No | Yes | 7 | 8 | 2 | 1 | | R:R:K349 | W:W:?2 | 23.03 | 1 | No | Yes | 9 | 0 | 1 | 0 | | R:R:L399 | R:R:S350 | 3 | 1 | Yes | No | 8 | 9 | 1 | 1 | | R:R:S350 | R:R:Y400 | 7.63 | 1 | No | Yes | 9 | 8 | 1 | 1 | | R:R:S350 | W:W:?2 | 10.22 | 1 | No | Yes | 9 | 0 | 1 | 0 | | R:R:T351 | R:R:Y400 | 7.49 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | | R:R:L352 | W:W:?2 | 5.65 | 0 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:T353 | W:W:?2 | 18.06 | 0 | No | Yes | 8 | 0 | 1 | 0 | | R:R:L354 | R:R:Y400 | 3.52 | 0 | No | Yes | 9 | 8 | 2 | 1 | | R:R:L395 | R:R:L399 | 2.77 | 0 | No | Yes | 6 | 8 | 2 | 1 | | R:R:L399 | R:R:V398 | 1.49 | 1 | Yes | No | 8 | 6 | 1 | 2 | | R:R:L403 | R:R:V398 | 2.98 | 1 | No | No | 5 | 6 | 1 | 2 | | R:R:L399 | R:R:L403 | 2.77 | 1 | Yes | No | 8 | 5 | 1 | 1 | | R:R:L399 | W:W:?2 | 6.59 | 1 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:Y400 | W:W:?2 | 1.6 | 1 | Yes | Yes | 8 | 0 | 1 | 0 | | R:R:L403 | W:W:?2 | 2.83 | 1 | No | Yes | 5 | 0 | 1 | 0 | | R:R:N404 | R:R:V407 | 4.43 | 0 | No | No | 9 | 9 | 1 | 2 | | R:R:N404 | W:W:?2 | 10.28 | 0 | No | Yes | 9 | 0 | 1 | 0 | | R:R:R346 | R:R:T341 | 1.29 | 0 | No | No | 8 | 6 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 11.00 | | Average Number Of Links With An Hub | 5.00 | | Average Interaction Strength | 7.89 | | Average Nodes In Shell | 32.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 48.00 | | Average Links Mediated by Hubs In Shell | 43.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
