Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R32 3.8375404
2A:A:E33 6.95416
3A:A:L39 4.495409
4A:A:K46 4.9075409
5A:A:I49 3.8407
6A:A:F191 7.274105
7A:A:H195 6.6325414
8A:A:F196 8.086676107
9A:A:F199 9.0225415
10A:A:Q204 6.604519
11A:A:S206 5.425418
12A:A:K210 6.18857719
13A:A:W211 6.05429719
14A:A:F215 6.686519
15A:A:I221 7.344198
16A:A:C224 4.075407
17A:A:Y230 4.9554118
18A:A:F250 6.6745159
19A:A:C254 4.0265155
20A:A:W258 9.24667615
21A:A:F259 7.214199
22A:A:F274 6.335119
23A:A:K277 5.8125119
24A:A:I278 3.0254116
25A:A:S281 2.3625407
26A:A:C286 4.57406
27A:A:Y287 5.901676207
28A:A:Y290 7.5025407
29A:A:Y296 7.91404
30A:A:Y302 8.90254206
31A:A:F307 6.584508
32A:A:R313 4.095404
33A:A:Y320 7.6585227
34A:A:F323 6.425404
35A:A:T324 8.065409
36A:A:F336 5.371676108
37A:A:D341 9.825408
38A:A:L353 5.4625437
39B:B:T34 4.135475
40B:B:I37 4.715472
41B:B:V40 5.38473
42B:B:I43 3.775473
43B:B:H54 11.042529
44B:B:Y59 9.628518
45B:B:M61 4.595426
46B:B:W63 7.07333627
47B:B:L70 6.7175425
48B:B:D76 5.788529
49B:B:I81 4.42557
50B:B:W82 10.3957729
51B:B:N88 6.665407
52B:B:K89 7.78833629
53B:B:H91 6.195455
54B:B:I93 5.815457
55B:B:L95 6.1925458
56B:B:W99 8.24375819
57B:B:Y105 4.89571756
58B:B:N110 8.29754124
59B:B:Y111 7.0745124
60B:B:C114 5.435458
61B:B:L117 4.408519
62B:B:C121 4.5325418
63B:B:I123 4.6785126
64B:B:Y124 5.39333656
65B:B:L126 4.93455
66B:B:T128 4.9454263
67B:B:E130 4.144263
68B:B:V133 6.8275454
69B:B:H142 7.82519
70B:B:Y145 6.5741018
71B:B:L146 5.0525417
72B:B:F151 5.55667609
73B:B:I157 5407
74B:B:T159 6.3925419
75B:B:S160 4.82416
76B:B:D163 8.435419
77B:B:C166 4.076518
78B:B:W169 9.77167618
79B:B:T173 5.4654165
80B:B:Q176 7.26514
81B:B:F180 8.53517
82B:B:H183 9.954519
83B:B:D186 5.768519
84B:B:V187 5.964519
85B:B:M188 5.5325418
86B:B:F199 9.95519
87B:B:V200 7.955446
88B:B:S201 4.915419
89B:B:C204 5.434517
90B:B:D205 8.0625419
91B:B:K209 9.54516
92B:B:L210 4.7275405
93B:B:W211 10.4817618
94B:B:E215 5.75754173
95B:B:R219 5.70254175
96B:B:Q220 8.0375447
97B:B:F222 9.1075448
98B:B:H225 9.825649
99B:B:D228 7.214519
100B:B:I232 5.8625448
101B:B:F234 4.98167645
102B:B:F235 10.6854136
103B:B:P236 8.18254137
104B:B:F241 7.69167646
105B:B:T243 5.67448
106B:B:D246 7.2175419
107B:B:D247 9.1775449
108B:B:R251 11.3525448
109B:B:F253 8.9425446
110B:B:D254 4.852509
111B:B:R256 9.38409
112B:B:D258 9.402547
113B:B:M262 8.425404
114B:B:Y264 7.334505
115B:B:I269 4.712594
116B:B:F278 6.5345137
117B:B:R283 8.422579
118B:B:L284 5.4575475
119B:B:L285 5.095406
120B:B:Y289 6.58429797
121B:B:D290 9.465406
122B:B:W297 5.2575498
123B:B:L300 6.1925476
124B:B:K301 3.88405
125B:B:R304 7.546595
126B:B:H311 8.604569
127B:B:M325 7.2525405
128B:B:W332 13719
129B:B:D333 7.126569
130B:B:F335 7.484564
131B:B:L336 6.2175427
132B:B:K337 7.236566
133B:B:W339 9.03833669
134G:G:R27 5.76333648
135G:G:Y40 11.54754136
136G:G:D48 5.77509
137G:G:L51 4.578506
138G:G:P60 7.8075429
139G:G:F61 6.322528
140R:R:G45 2.4825408
141R:R:N49 7.165409
142R:R:Q63 5.224278
143R:R:F69 5.975689
144R:R:N72 8.17754149
145R:R:D77 9.065439
146R:R:L120 3.825405
147R:R:H131 8.475639
148R:R:N137 9.4325489
149R:R:R138 7.8625439
150R:R:Y139 5.68286787
151R:R:L140 5.1925486
152R:R:R144 5487
153R:R:Y153 7.31429786
154R:R:W166 8.714148
155R:R:Q204 6.5375437
156R:R:L208 5.078538
157R:R:Y212 6.33639
158R:R:R225 5.4275405
159R:R:F293 7.86167639
160R:R:L300 4.5765286
161R:R:S321 3.64254286
162R:R:L328 4.8025439
163R:R:N332 7.65539
164R:R:Y336 9.87439
165R:R:W338 7.475435
166R:R:F343 7.226676279
167W:W:?1 8.198899250
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 14.17227.97YesYes259
2B:B:L70 B:B:M61 16.89475.65YesYes256
3B:B:C317 B:B:M61 24.77854.86NoYes076
4B:B:C317 B:B:S316 25.14393.44NoNo079
5B:B:S316 B:B:W332 25.3273.71NoYes099
6B:B:W332 B:B:Y59 12.2818.68YesYes198
7B:B:Q75 B:B:Y59 12.530216.91NoYes198
8B:B:Q75 B:B:W99 12.67035.48NoYes199
9A:A:W258 B:B:W332 15.72466.56YesYes159
10A:A:N256 A:A:W258 33.3245.65NoYes085
11A:A:F259 A:A:N256 33.56747.25YesNo098
12A:A:F259 A:A:I212 16.59655.02YesNo098
13A:A:I212 A:A:R208 16.66226.26NoNo089
14A:A:L39 A:A:R208 62.54483.64YesNo099
15A:A:G40 A:A:L39 92.58561.71NoYes099
16A:A:G40 A:A:K46 96.92555.23NoYes099
17A:A:K46 A:A:L38 97.54125.64YesNo098
18A:A:L38 A:A:M198 1008.48NoNo087
19A:A:L36 A:A:M198 49.97744.24NoNo077
20A:A:F196 A:A:L36 49.95893.65YesNo077
21A:A:F259 A:A:I221 17.1078.79YesYes1998
22A:A:I221 A:A:L37 17.87894.28YesNo089
23A:A:L37 A:A:L39 29.98586.92NoYes099
24A:A:F215 B:B:W99 10.76759.02YesYes199
25A:A:F215 A:A:L37 14.503912.18YesNo099
26A:A:F189 A:A:M198 50.0443.73NoNo097
27A:A:F189 A:A:F196 49.932116.08NoYes097
28A:A:F196 A:A:F336 99.62633.22YesYes1078
29A:A:D337 A:A:F336 49.76053.58NoYes048
30A:A:D337 R:R:R225 49.707610.72NoYes045
31R:R:R218 R:R:R225 99.10773.2NoYes075
32A:A:I344 R:R:R218 98.98758.77NoNo067
33A:A:I344 R:R:S222 98.86723.1NoNo068
34A:A:D341 R:R:S222 98.74695.89YesNo088
35A:A:F336 A:A:T340 49.69397.78YesNo086
36A:A:T340 R:R:R225 49.64065.17NoYes065
37A:A:D341 A:A:K345 97.407911.06YesNo085
38A:A:F354 A:A:K345 97.27124.96NoNo055
39A:A:F354 A:A:L348 96.90836.09NoNo059
40A:A:L348 W:W:?1 96.65325.2NoYes2590
41R:R:V286 W:W:?1 51.93535.6NoYes080
42R:R:V286 R:R:Y212 43.62296.31NoYes089
43R:R:C290 W:W:?1 43.88286.96NoYes080
44R:R:C290 R:R:Y212 43.62794.03NoYes089
45R:R:L208 R:R:Y212 48.08325.86YesYes389
46R:R:H131 R:R:L208 36.5573.86YesYes398
47R:R:H131 R:R:N332 71.044510.2YesYes399
48R:R:D77 R:R:N332 56.147314.81YesYes399
49R:R:D77 R:R:N49 41.60276.73YesYes099
50R:R:C74 R:R:N49 15.67243.15NoYes089
51R:R:C74 R:R:V52 15.13256.83NoNo089
52R:R:F343 R:R:V52 29.19232.62YesNo099
53R:R:L289 R:R:Y212 37.59268.21NoYes089
54R:R:H131 R:R:L289 36.54085.14YesNo098
55R:R:N49 R:R:P333 23.774714.66YesNo099
56R:R:P333 R:R:V52 15.14113.53NoNo099
57B:B:S147 B:B:Y145 46.38786.36NoYes198
58B:B:S147 B:B:S160 46.53583.26NoYes196
59B:B:C166 B:B:S160 22.71323.44YesYes186
60B:B:C218 B:B:W211 35.8335.22NoYes158
61B:B:C218 G:G:Q18 42.55154.58NoNo059
62G:G:M21 G:G:Q18 42.16255.44NoNo019
63B:B:M217 G:G:M21 41.76284.33NoNo031
64B:B:M217 B:B:R219 40.15834.96NoYes1735
65B:B:L210 B:B:R219 39.36213.64YesYes055
66B:B:L210 B:B:Q220 21.69366.65YesYes057
67B:B:D258 B:B:Q220 10.043610.44YesYes477
68B:B:I18 G:G:R27 13.67092.51NoYes078
69B:B:I18 B:B:Q17 12.8672.74NoNo074
70B:B:Q17 G:G:A23 12.06314.55NoNo048
71B:B:L14 G:G:A23 11.25911.58NoNo088
72B:B:F199 B:B:W211 14.787824.05YesYes198
73B:B:S201 B:B:W211 14.48487.41YesYes198
74B:B:S160 B:B:V187 15.56958.08YesYes169
75B:B:D290 B:B:R314 19.572823.82YesNo068
76B:B:C271 B:B:D290 14.184.67NoYes056
77B:B:C271 B:B:Y289 10.18884.03NoYes957
78B:B:L210 B:B:V200 13.25554.47YesYes056
79R:R:D77 R:R:S329 14.06667.36YesNo399
80R:R:S329 R:R:V80 27.02338.08NoNo099
81R:R:C326 R:R:V80 15.13453.42NoNo059
82R:R:C326 R:R:W84 12.97316.53NoNo056
83R:R:N332 R:R:S127 14.57674.47YesNo399
84R:R:S127 R:R:S329 14.03734.89NoNo399
85R:R:F343 R:R:Q63 10.81484.68YesYes2798
86R:R:F343 R:R:L55 12.97764.87YesNo098
87R:R:G123 R:R:V80 10.81461.84NoNo069
88A:A:R208 A:A:W211 46.06526NoYes099
89A:A:W211 B:B:Y145 46.14736.75YesYes198
90A:A:W258 B:B:R314 17.16254YesNo158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:F354 A:A:L348 6.09 0 No No 5 9 2 1
A:A:L348 R:R:V219 5.96 25 No No 9 8 1 1
A:A:L348 W:W:?1 5.2 25 No Yes 9 0 1 0
A:A:L353 R:R:V286 5.96 3 Yes No 7 8 2 1
R:R:C290 R:R:L209 3.17 0 No No 8 4 1 2
R:R:V286 R:R:Y212 6.31 0 No Yes 8 9 1 2
R:R:C290 R:R:Y212 4.03 0 No Yes 8 9 1 2
R:R:L213 W:W:?1 5.2 0 No Yes 4 0 1 0
R:R:V216 W:W:?1 13.07 0 No Yes 6 0 1 0
R:R:V219 W:W:?1 14 25 No Yes 8 0 1 0
R:R:R220 W:W:?1 4.57 0 No Yes 6 0 1 0
R:R:G283 W:W:?1 9.65 0 No Yes 7 0 1 0
R:R:V286 W:W:?1 5.6 0 No Yes 8 0 1 0
R:R:C291 R:R:L287 3.17 0 No No 6 6 2 1
R:R:L287 W:W:?1 9.54 0 No Yes 6 0 1 0
R:R:C290 W:W:?1 6.96 0 No Yes 8 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
20.00Single6LN2PF-063722226LN2-GLP-1-PF-06372222
15.38Single7EB2rac-BHFF7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
13.33Single8HNNSCH5467388HNN-CXCR3-SCH546738
12.50Single4K5YCP-3763954K5Y-CRF1-CP-376395
12.50Single5VEWPF-063722225VEW-GLP-1-PF-06372222
12.50Single6KJVPF-063722226KJV-GLP-1-PF-06372222
12.50Single6KK1PF-063722226KK1-GLP-1-PF-06372222
12.50Single7C7QBHFF7C7Q-GABAB1, GABAB2-Baclofen-BHFF
11.76Single8XQLAristolochic acid A8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single4Z9GCP-3763954Z9G-CRF1-CP-376395
11.11Single8GTIBMK-C2058GTI-CRF1-BMK-C205
10.53Single8GTGBMK-I1528GTG-CRF1-BMK-I152
10.00Single7E14PubChem 1560227387E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.00Single7EVMPubChem 1560227387EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
9.52Single8GTMBMK-C2038GTM-CRF1-BMK-C203
8.33Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
8.33Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
8.33Single8FN0SBI-5538FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
6.67Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VEXNNC06405VEX-GLP-1-NNC0640
6.25Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
6.25Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
5.88Single8XQNAristolochic acid A8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.56Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.56Single8XQOAristolochic acid A8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.56Single8XQSFlufenamic acid8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
5.26Single5XF1NNC06405XF1-Glucagon-NNC0640
5.26Single6QZHCmp2105; Na6QZH-CCR7-Cmp2105; Na
5.26Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
5.26Single8JPCSBI-553; GDP; Mg8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
5.26Single8JPFSBI-5538JPF-NTS1-Neurotensin-SBI-553
5.26Single8XQLAristolochic acid A8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00Single6LFLPubChem 1534669966LFL-CXCR2-PubChem 153466996
4.76Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
4.55Single5LWEVercirnon5LWE-CCR9-Vercirnon
4.55Single8ZYUSBI-5538ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
4.00Single8ZYTSBI-5538ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2

PDB Summary
PDB 7EJX
Class A
SubFamily Orphan
Type Orphan
SubType GPR88
Species Homo Sapiens
Ligand -
Other Ligand(s) (1R;2R)-2-PCCA
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.4
Date 2022-04-13
D.O.I. doi.org/10.1038/s41467-022-30081-5
Net Summary
Imin 3
Number of Linked Nodes 788
Number of Links 995
Number of Hubs 167
Number of Links mediated by Hubs 615
Number of Communities 28
Number of Nodes involved in Communities 249
Number of Links involved in Communities 371
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 6380345
Length Of Smallest Path 3
Average Path Length 39.8086
Length of Longest Path 61
Minimum Path Strength 1.365
Average Path Strength 6.21272
Maximum Path Strength 26.18
Minimum Path Correlation 0.71
Average Path Correlation 0.994056
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 32.6155
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.9709
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • system process   • nervous system process   • biological regulation   • action potential   • transmission of nerve impulse   • cell communication   • neuronal action potential   • cellular process   • regulation of biological quality   • regulation of membrane potential   • behavior   • locomotory behavior   • cellular response to stimulus   • response to light stimulus   • response to stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular response to radiation   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • phototransduction   • detection of light stimulus   • detection of external stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • response to external stimulus   • detection of abiotic stimulus   • detection of stimulus   • signal transduction   • G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • learning   • learning or memory   • motor learning   • cognition   • neuromuscular process   • neuromuscular process controlling balance   • membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • intracellular organelle   • nucleus   • intracellular membrane-bounded organelle
Gene OntologyCellular Component• membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • intracellular organelle   • nucleus   • intracellular membrane-bounded organelle   • ciliary membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJ5F
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeJ5F
Name(1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide
Synonyms
Identifier
FormulaC30 H37 N3 O
Molecular Weight455.634
SMILES
PubChem58466521
Formal Charge0
Total Atoms71
Total Chiral Atoms4
Total Bonds74
Total Aromatic Bonds18

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7EJX_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EJX_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EJX_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9GZN0
Sequence
>7EJX_Chain_R
LYSGLAIGG TLANGMVIY LVSSFRKLQ TTSNAFIVN GCAADLSVC 
ALWMPRLLR GGLLGLGLT VSLLSHCLV ALNRYLLIT RAPATYQAL 
YQRRHTAGM LALSWALAL GLVLLLPPW AHYPALLAA AALLAQTAL 
LLHCYLGIV RRVRVSVKR VSVRLSGLS VLLLCCVFL LATQPLVWV 
SLASGFSLP VPWGVQAAS WLLCCALSA LNPLLYTWR NEEFRRSVR 
SVLP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EJXAOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCAGi1/β1/γ22.42022-04-13doi.org/10.1038/s41467-022-30081-5
7EJX (No Gprot) AOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCA2.42022-04-13doi.org/10.1038/s41467-022-30081-5
7WZ4AOrphanOrphanGPR88Homo sapiens--Gi1/β1/γ232022-10-26doi.org/10.1038/s41467-022-30081-5
7WZ4 (No Gprot) AOrphanOrphanGPR88Homo sapiens--32022-10-26doi.org/10.1038/s41467-022-30081-5




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