Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:G45 2.4825408
2R:R:N49 7.165409
3R:R:Q63 5.224198
4R:R:F69 5.975689
5R:R:N72 8.17754139
6R:R:D77 9.065439
7R:R:L120 3.825405
8R:R:H131 8.475639
9R:R:N137 9.4325489
10R:R:R138 7.8625439
11R:R:Y139 5.68286787
12R:R:L140 5.1925486
13R:R:R144 5487
14R:R:Y153 7.31429786
15R:R:W166 8.714138
16R:R:Q204 6.5375437
17R:R:L208 5.078538
18R:R:Y212 6.33639
19R:R:R225 5.4275405
20R:R:F293 7.86167639
21R:R:L300 4.5765216
22R:R:S321 3.64254216
23R:R:L328 4.8025439
24R:R:N332 7.65539
25R:R:Y336 9.87439
26R:R:W338 7.475435
27R:R:F343 7.226676199
28A:A:R32 3.8375404
29A:A:E33 6.95416
30A:A:L39 4.495409
31A:A:K46 4.9075409
32A:A:I49 3.8407
33A:A:F191 7.274105
34A:A:H195 6.6325414
35A:A:F196 8.086676107
36A:A:F199 9.0225415
37A:A:Q204 6.604519
38A:A:S206 5.425418
39A:A:K210 6.18857719
40A:A:W211 6.05429719
41A:A:F215 6.686519
42A:A:I221 7.344238
43A:A:C224 4.075407
44A:A:S228 6.4254119
45A:A:Y230 4.9554118
46A:A:F250 6.6745159
47A:A:C254 4.0265155
48A:A:W258 9.24667615
49A:A:F259 7.214239
50A:A:F274 6.335119
51A:A:K277 5.8125119
52A:A:I278 3.0254116
53A:A:S281 2.3625407
54A:A:C286 4.57406
55A:A:Y287 6.986167
56A:A:Y296 9.3125404
57A:A:Y302 9.18254166
58A:A:F307 6.584508
59A:A:R313 4.095404
60A:A:Y320 7.6585257
61A:A:F323 6.425404
62A:A:T324 8.065409
63A:A:F336 5.371676108
64A:A:D341 9.825408
65A:A:L353 5.4625437
66B:B:T34 4.135475
67B:B:I37 4.715472
68B:B:V40 5.38473
69B:B:I43 3.775473
70B:B:H54 11.042529
71B:B:Y59 9.628518
72B:B:M61 4.595426
73B:B:W63 7.07333627
74B:B:L70 6.7175425
75B:B:D76 5.788529
76B:B:I81 4.42557
77B:B:W82 10.3957729
78B:B:N88 6.665407
79B:B:K89 7.78833629
80B:B:H91 6.195455
81B:B:I93 5.815457
82B:B:L95 6.1925458
83B:B:W99 8.24375819
84B:B:Y105 4.89571756
85B:B:N110 8.29754124
86B:B:Y111 7.0745124
87B:B:C114 5.435458
88B:B:L117 4.408519
89B:B:C121 4.5325418
90B:B:I123 4.6785126
91B:B:Y124 5.39333656
92B:B:L126 4.93455
93B:B:T128 4.9454283
94B:B:E130 4.144283
95B:B:V133 6.8275454
96B:B:H142 7.82519
97B:B:Y145 6.5741018
98B:B:L146 5.0525417
99B:B:F151 5.55667609
100B:B:I157 5407
101B:B:T159 6.3925419
102B:B:S160 4.82416
103B:B:D163 8.435419
104B:B:C166 4.076518
105B:B:W169 9.77167618
106B:B:T173 5.4654175
107B:B:Q176 7.26514
108B:B:F180 8.53517
109B:B:H183 9.954519
110B:B:D186 5.768519
111B:B:V187 5.964519
112B:B:M188 5.5325418
113B:B:F199 9.95519
114B:B:V200 7.955446
115B:B:S201 4.915419
116B:B:C204 5.434517
117B:B:D205 8.0625419
118B:B:K209 9.54516
119B:B:L210 4.7275405
120B:B:W211 10.4817618
121B:B:E215 5.75754183
122B:B:R219 5.70254185
123B:B:Q220 8.0375447
124B:B:F222 9.1075448
125B:B:H225 9.825649
126B:B:D228 7.214519
127B:B:I232 5.8625448
128B:B:F234 4.98167645
129B:B:F235 10.6854146
130B:B:P236 8.18254147
131B:B:F241 7.69167646
132B:B:T243 5.67448
133B:B:D246 7.2175419
134B:B:D247 9.1775449
135B:B:R251 11.3525448
136B:B:F253 8.9425446
137B:B:D254 4.852509
138B:B:R256 9.38409
139B:B:D258 9.402547
140B:B:M262 8.425404
141B:B:Y264 7.334505
142B:B:I269 4.712594
143B:B:F278 6.5345147
144B:B:R283 8.422579
145B:B:L284 5.4575475
146B:B:L285 5.095406
147B:B:Y289 6.58429797
148B:B:D290 9.465406
149B:B:W297 5.2575498
150B:B:L300 6.1925476
151B:B:K301 3.88405
152B:B:R304 7.546595
153B:B:H311 8.604569
154B:B:M325 7.2525405
155B:B:W332 13719
156B:B:D333 7.91469
157B:B:F335 7.484564
158B:B:L336 6.2175427
159B:B:K337 7.236566
160B:B:W339 9.03833669
161G:G:R27 5.76333648
162G:G:Y40 11.54754146
163G:G:D48 5.77509
164G:G:L51 4.578506
165G:G:P60 7.8075429
166G:G:F61 6.322528
167W:W:?1 7.66110220
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:N49 R:R:P333 23.762114.66YesNo099
2R:R:C74 R:R:N49 15.6643.15NoYes089
3R:R:C74 R:R:V52 15.12446.83NoNo089
4R:R:P333 R:R:V52 15.13283.53NoNo099
5R:R:D77 R:R:N49 41.58066.73YesYes099
6R:R:F343 R:R:Q63 10.80894.68YesYes1998
7R:R:F343 R:R:V52 29.17642.62YesNo099
8R:R:F343 R:R:L55 12.97054.87YesNo098
9B:B:D290 B:B:R314 19.23623.82YesNo068
10A:A:W258 B:B:R314 16.86454YesNo158
11A:A:N256 A:A:W258 32.64125.65NoYes085
12A:A:F259 A:A:N256 32.87887.25YesNo098
13A:A:F259 A:A:I212 16.26875.02YesNo098
14A:A:I212 A:A:R208 16.33336.26NoNo089
15A:A:L39 A:A:R208 61.13283.64YesNo099
16A:A:G40 A:A:L39 90.56441.71NoYes099
17A:A:G40 A:A:K46 94.23565.23NoYes099
18A:A:K46 A:A:L38 96.11125.64YesNo098
19A:A:L38 A:A:M198 1008.48NoNo087
20A:A:L36 A:A:M198 49.97674.24NoNo077
21A:A:F196 A:A:L36 49.95643.65YesNo077
22A:A:F196 A:A:F336 99.61883.22YesYes1078
23A:A:D337 A:A:F336 49.75493.58NoYes048
24A:A:D337 R:R:R225 49.700110.72NoYes045
25R:R:R218 R:R:R225 99.09373.2NoYes075
26A:A:I344 R:R:R218 98.97328.77NoNo067
27A:A:I344 R:R:S222 98.85263.1NoNo068
28A:A:D341 R:R:S222 98.7325.89YesNo088
29A:A:D341 A:A:K345 97.511211.06YesNo085
30A:A:F354 A:A:K345 97.35888.69NoNo055
31A:A:F354 A:A:L348 97.11656.09NoNo059
32A:A:L348 W:W:?1 96.86135.2NoYes2290
33R:R:V286 W:W:?1 51.91555.6NoYes080
34R:R:V286 R:R:Y212 43.60616.31NoYes089
35R:R:L208 R:R:Y212 48.06395.86YesYes389
36R:R:H131 R:R:L208 36.54183.86YesYes398
37R:R:H131 R:R:N332 71.013110.2YesYes399
38R:R:D77 R:R:N332 56.118514.81YesYes399
39A:A:F259 A:A:I221 16.74268.79YesYes2398
40A:A:I221 A:A:L37 17.34454.28YesNo089
41A:A:L37 A:A:L39 29.37796.92NoYes099
42A:A:F189 A:A:M198 50.04343.73NoNo097
43A:A:F189 A:A:F196 49.930216.08NoYes097
44A:A:F336 A:A:T340 49.68837.78YesNo086
45A:A:T340 R:R:R225 49.63465.17NoYes065
46R:R:C290 W:W:?1 43.8666.96NoYes080
47R:R:C290 R:R:Y212 43.6114.03NoYes089
48R:R:L289 R:R:Y212 37.57798.21NoYes089
49R:R:H131 R:R:L289 36.5265.14YesNo098
50R:R:C326 R:R:W84 12.96616.53NoNo056
51R:R:C326 R:R:V80 15.12633.42NoNo059
52R:R:S329 R:R:V80 27.00888.08NoNo099
53R:R:S127 R:R:S329 14.03014.89NoNo399
54R:R:G123 R:R:V80 10.80871.84NoNo069
55A:A:F215 A:A:L37 14.020612.18YesNo099
56A:A:F215 B:B:W99 10.52959.02YesYes199
57B:B:L70 B:B:W82 13.84047.97YesYes259
58B:B:L70 B:B:M61 16.49915.65YesYes256
59B:B:C317 B:B:M61 24.19824.86NoYes076
60B:B:C317 B:B:S316 24.55513.44NoNo079
61B:B:S316 B:B:W332 24.7343.71NoYes099
62A:A:W258 B:B:W332 15.35046.56YesYes159
63B:B:W332 B:B:Y59 12.01198.68YesYes198
64B:B:Q75 B:B:Y59 12.255616.91NoYes198
65B:B:Q75 B:B:W99 12.39295.48NoYes199
66A:A:R208 A:A:W211 44.97796NoYes099
67A:A:W211 B:B:Y145 44.89256.75YesYes198
68B:B:L14 G:G:A23 10.96111.58NoNo088
69B:B:Q17 G:G:A23 11.74384.55NoNo048
70B:B:I18 B:B:Q17 12.52642.74NoNo074
71B:B:I18 G:G:R27 13.3092.51NoYes078
72B:B:L210 B:B:Q220 21.11946.65YesYes057
73B:B:L210 B:B:R219 38.32013.64YesYes055
74B:B:M217 B:B:R219 39.09524.96NoYes1835
75B:B:M217 G:G:M21 40.65724.33NoNo031
76G:G:M21 G:G:Q18 41.04635.44NoNo019
77B:B:C218 G:G:Q18 41.4254.58NoNo059
78B:B:S160 B:B:V187 15.15718.08YesYes169
79B:B:S147 B:B:S160 45.30273.26NoYes196
80B:B:S147 B:B:Y145 45.15796.36NoYes198
81B:B:C218 B:B:W211 34.88455.22NoYes158
82B:B:S201 B:B:W211 14.1017.41YesYes198
83B:B:C166 B:B:S160 22.11143.44YesYes186
84B:B:F199 B:B:W211 14.39724.05YesYes198
85B:B:C271 B:B:D290 13.84584.67NoYes056
86B:B:L210 B:B:V200 12.90464.47YesYes056
87R:R:D77 R:R:S329 14.05877.36YesNo399
88R:R:N332 R:R:S127 14.56924.47YesNo399
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C290 R:R:L209 3.17 0 No No 8 4 1 2
R:R:V286 R:R:Y212 6.31 0 No Yes 8 9 1 2
R:R:C290 R:R:Y212 4.03 0 No Yes 8 9 1 2
R:R:L213 W:W:?1 5.2 0 No Yes 4 0 1 0
R:R:V216 W:W:?1 13.07 0 No Yes 6 0 1 0
A:A:L348 R:R:V219 5.96 22 No No 9 8 1 1
R:R:V219 W:W:?1 14 22 No Yes 8 0 1 0
R:R:R220 W:W:?1 4.57 0 No Yes 6 0 1 0
R:R:R280 R:R:S282 5.27 0 No No 5 9 2 1
R:R:G283 W:W:?1 9.65 0 No Yes 7 0 1 0
A:A:L353 R:R:V286 5.96 3 Yes No 7 8 2 1
R:R:V286 W:W:?1 5.6 0 No Yes 8 0 1 0
R:R:C291 R:R:L287 3.17 0 No No 6 6 2 1
R:R:L287 W:W:?1 9.54 0 No Yes 6 0 1 0
R:R:C290 W:W:?1 6.96 0 No Yes 8 0 1 0
A:A:F354 A:A:L348 6.09 0 No No 5 9 2 1
A:A:L348 W:W:?1 5.2 22 No Yes 9 0 1 0
R:R:S282 W:W:?1 2.82 0 No Yes 9 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
21.43Consensusgi_gabaOther Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
18.75Single6KK1PubChem 681786306KK1-GLP-1-PubChem 68178630
18.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
16.67Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
15.00Single6LN2PubChem 681786306LN2-GLP-1-PubChem 68178630
14.29Single7EB2rac-BHFF7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
14.29Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensusgabab_onOther Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
14.29Consensusgi_class-cOther Ligandgi_mglu gi_gaba
13.64Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Single4K5YCP-3763954K5Y-CRF1-CP-376395
11.76Single6KJVPubChem 681786306KJV-GLP-1-PubChem 68178630
11.76Single7C7QPubChem 70238487C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
11.76Single8HNNSCH5467388HNN-CXCR3-SCH546738
11.11Single5VEWPF-063722225VEW-GLP-1-PF-06372222
10.53Single4Z9GCP-3763954Z9G-CRF1-CP-376395
10.53Single8GTIBMK-C2058GTI-CRF1-BMK-C205
10.00Single8FN0PubChem 1186104278FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
9.09Single7E14PubChem 1560227387E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
9.09Single7EVMPubChem 1560227387EVM-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
9.09Single8GTMBMK-C2038GTM-CRF1-BMK-C203
7.69Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
7.69Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
5.88Single5VEXNNC06405VEX-GLP-1-NNC0640
5.88Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
5.00Single6QZHHY-133073; Na6QZH-CCR7-HY-133073; Na
5.00Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Single8JPFPubChem 1186104278JPF-NTS1-Neurotensin-PubChem 118610427
5.00Consensusccr7_off_alloOther Ligand6QZH-CCR7-HY-133073; Na
4.76Single5XF1NNC06405XF1-Glucagon-NNC0640
4.76Single6LFLPubChem 1534669966LFL-CXCR2-PubChem 153466996
4.76Single8JPCPubChem 118610427; GDP; Mg8JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.76Consensusffa3_on_alloOther Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.55Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.35Single5LWEVercirnon5LWE-CCR9-Vercirnon
4.35Consensusccr9_off_alloOther Ligand5LWE-CCR9-Vercirnon
3.23Single3VG9Antibody3VG9-A2A-ZM241385-Antibody
3.03Single3VGAAntibody3VGA-A2A-ZM241385-Antibody

PDB Summary
PDB 7EJX
Class A
SubFamily Orphan
Type A orphans
SubType GPR88
Species Homo sapiens
Ligand -
Other Ligand(s) (1R;2R)-2-PCCA
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.4
Date 2022-04-13
D.O.I. 10.1038/s41467-022-30081-5
Net Summary
Imin 3
Number of Linked Nodes 790
Number of Links 997
Number of Hubs 167
Number of Links mediated by Hubs 615
Number of Communities 28
Number of Nodes involved in Communities 249
Number of Links involved in Communities 371
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 6504184
Length Of Smallest Path 3
Average Path Length 39.5904
Length of Longest Path 61
Minimum Path Strength 1.44
Average Path Strength 6.33534
Maximum Path Strength 26.18
Minimum Path Correlation 0.71
Average Path Correlation 0.994681
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 32.8874
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.1683
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeJ5F
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeJ5F
Name(1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide
Synonyms
Identifier(1~{R},2~{R})-~{N}-[(2~{S},3~{S})-2-azanyl-3-methyl-pentyl]-~{N}-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide
FormulaC30 H37 N3 O
Molecular Weight455.634
SMILESCCCc1ccc(cc1)c2ccc(cc2)N(C[C@H]([C@@H](C)CC)N)C(=O)[C@@H]3C[C@H]3c4ccccn4
PubChem58466521
Formal Charge0
Total Atoms71
Total Chiral Atoms4
Total Bonds74
Total Aromatic Bonds18

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9GZN0
Sequence
>7EJX_Chain_R
LYSGLAIGG TLANGMVIY LVSSFRKLQ TTSNAFIVN GCAADLSVC 
ALWMPRLLR GGLLGLGLT VSLLSHCLV ALNRYLLIT RAPATYQAL 
YQRRHTAGM LALSWALAL GLVLLLPPW AHYPALLAA AALLAQTAL 
LLHCYLGIV RRVRVSVKR VSVRLSGLS VLLLCCVFL LATQPLVWV 
SLASGFSLP VPWGVQAAS WLLCCALSA LNPLLYTWR NEEFRRSVR 
SVLP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7EJX_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EJX_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EJX_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EJXAOrphanA orphansGPR88Homo sapiens-(1R;2R)-2-PCCAGi1/&β;1/&γ;22.42022-04-1310.1038/s41467-022-30081-5
7WZ4AOrphanA orphansGPR88Homo sapiens--Gi1/&β;1/&γ;232022-10-2610.1038/s41467-022-30081-5




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Download 7EJX.zip



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