psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L41	R:R:Y38	3.52	No	No	0	6	4
2	R:R:L323	R:R:Y38	12.89	No	No	0	5	4
3	R:R:P86	R:R:S39	8.91	No	No	0	9	4
4	R:R:G40	R:R:I43	3.53	No	No	0	5	5
5	R:R:A330	R:R:L41	3.15	No	No	0	6	6
6	R:R:I43	R:R:M85	2.92	No	No	0	5	7
7	R:R:C81	R:R:G45	3.92	No	Yes	0	7	8
8	R:R:L78	R:R:T46	4.42	No	No	0	7	6
9	R:R:A48	R:R:P333	3.74	No	No	0	9	9
10	R:R:C74	R:R:N49	3.15	No	Yes	0	8	9
11	R:R:D77	R:R:N49	6.73	Yes	Yes	0	9	9
12	R:R:L78	R:R:N49	4.12	No	Yes	0	7	9
13	R:R:N49	R:R:P333	14.66	Yes	No	0	9	9
14	R:R:L55	R:R:M51	2.83	No	No	0	8	6
15	R:R:C74	R:R:V52	6.83	No	No	0	8	9
16	R:R:P333	R:R:V52	3.53	No	No	0	9	9
17	R:R:I53	R:R:V71	4.61	No	No	0	8	8
18	R:R:S58	R:R:Y54	10.17	No	No	0	6	5
19	R:R:F343	R:R:L55	4.87	Yes	No	0	9	8
20	R:R:L55	R:R:S346	9.01	No	No	0	8	8
21	R:R:Q63	R:R:V56	4.3	Yes	No	0	8	9
22	R:R:V56	R:R:V71	11.22	No	No	0	9	8
23	R:R:F59	R:R:S346	10.57	No	No	0	8	8
24	R:R:E342	R:R:L62	11.93	No	No	0	7	9
25	R:R:N67	R:R:Q63	9.24	No	Yes	4	9	8
26	R:R:F343	R:R:Q63	4.68	Yes	Yes	4	9	8
27	R:R:T158	R:R:T65	4.71	No	No	0	7	6
28	R:R:N137	R:R:S66	5.96	Yes	No	0	9	9
29	R:R:F343	R:R:N67	7.25	Yes	No	4	9	9
30	R:R:F69	R:R:L133	8.53	Yes	No	0	9	5
31	R:R:F69	R:R:N137	9.67	Yes	Yes	2	9	9
32	R:R:F69	R:R:Y153	5.16	Yes	Yes	2	9	6
33	R:R:F69	R:R:T158	3.89	Yes	No	0	9	7
34	R:R:F69	R:R:M161	3.73	Yes	No	2	9	7
35	R:R:F69	R:R:L162	4.87	Yes	No	0	9	7
36	R:R:I70	R:R:V134	3.07	No	No	1	9	9
37	R:R:I70	R:R:Y336	9.67	No	Yes	1	9	9
38	R:R:N72	R:R:S130	5.96	Yes	No	0	9	8
39	R:R:L162	R:R:N72	10.98	No	Yes	0	7	9
40	R:R:N72	R:R:S165	4.47	Yes	No	3	9	5
41	R:R:N72	R:R:W166	11.3	Yes	Yes	3	9	8
42	R:R:G73	R:R:S130	3.71	No	No	0	9	8
43	R:R:A76	R:R:V126	3.39	No	No	3	8	8
44	R:R:A76	R:R:W166	3.89	No	Yes	3	8	8
45	R:R:D77	R:R:S127	7.36	Yes	No	1	9	9
46	R:R:D77	R:R:S329	7.36	Yes	No	1	9	9
47	R:R:D77	R:R:N332	14.81	Yes	Yes	1	9	9
48	R:R:C326	R:R:V80	3.42	No	No	0	5	9
49	R:R:S329	R:R:V80	8.08	No	No	0	9	9
50	R:R:L119	R:R:L83	6.92	No	No	0	5	5
51	R:R:L120	R:R:W84	9.11	Yes	No	0	5	6
52	R:R:C326	R:R:W84	6.53	No	No	0	5	6
53	R:R:M85	R:R:P86	3.35	No	No	0	7	9
54	R:R:R113	R:R:R116	4.26	No	No	0	8	5
55	R:R:A169	R:R:L122	3.15	No	No	0	7	6
56	R:R:C326	R:R:L124	3.17	No	No	0	5	6
57	R:R:L129	R:R:T125	2.95	No	No	0	4	7
58	R:R:A169	R:R:T125	5.03	No	No	0	7	7
59	R:R:V126	R:R:W166	14.71	No	Yes	3	8	8
60	R:R:S127	R:R:S329	4.89	No	No	1	9	9
61	R:R:N332	R:R:S127	4.47	Yes	No	1	9	9
62	R:R:L128	R:R:Q204	3.99	No	Yes	0	7	7
63	R:R:H131	R:R:L208	3.86	Yes	Yes	1	9	8
64	R:R:H131	R:R:L289	5.14	Yes	No	0	9	8
65	R:R:F293	R:R:H131	10.18	Yes	Yes	1	9	9
66	R:R:H131	R:R:L328	5.14	Yes	Yes	1	9	9
67	R:R:H131	R:R:N332	10.2	Yes	Yes	1	9	9
68	R:R:H131	R:R:Y336	16.33	Yes	Yes	1	9	9
69	R:R:C132	R:R:Q204	7.63	No	Yes	0	7	7
70	R:R:C132	R:R:L207	6.35	No	No	0	7	5
71	R:R:R138	R:R:V134	6.54	No	No	0	9	9
72	R:R:V134	R:R:Y336	8.83	No	Yes	1	9	9
73	R:R:A135	R:R:L208	3.15	No	Yes	1	8	8
74	R:R:A135	R:R:Y212	5.34	No	Yes	1	8	9
75	R:R:L136	R:R:L140	4.15	No	Yes	2	6	6
76	R:R:L136	R:R:Y153	3.52	No	Yes	2	6	6
77	R:R:N137	R:R:Y149	6.98	Yes	No	2	9	9
78	R:R:N137	R:R:Y153	15.12	Yes	Yes	2	9	6
79	R:R:R138	R:R:Y212	8.23	No	Yes	0	9	9
80	R:R:L140	R:R:Y139	3.52	Yes	Yes	2	6	7
81	R:R:T143	R:R:Y139	12.48	No	Yes	2	8	7
82	R:R:R144	R:R:Y139	6.17	Yes	Yes	2	7	7
83	R:R:H210	R:R:Y139	4.36	No	Yes	0	4	7
84	R:R:C211	R:R:Y139	6.72	No	Yes	0	7	7
85	R:R:G214	R:R:Y139	2.9	No	Yes	0	5	7
86	R:R:I215	R:R:Y139	3.63	No	Yes	0	9	7
87	R:R:L140	R:R:R144	6.07	Yes	Yes	2	6	7
88	R:R:L140	R:R:Y153	7.03	Yes	Yes	2	6	6
89	R:R:L141	R:R:Y149	16.41	No	No	0	8	9
90	R:R:I142	R:R:T143	3.04	No	No	0	9	8
91	R:R:I142	R:R:I215	5.89	No	No	0	9	9
92	R:R:R144	R:R:T143	3.88	Yes	No	2	7	8
93	R:R:R144	R:R:T148	3.88	Yes	No	0	7	6
94	R:R:Y149	R:R:Y153	10.92	No	Yes	2	9	6
95	R:R:L152	R:R:Y153	5.86	No	Yes	0	5	6
96	R:R:M161	R:R:Y153	3.59	No	Yes	2	7	6
97	R:R:H157	R:R:Q154	6.18	No	No	0	6	8
98	R:R:H157	R:R:R156	5.64	No	No	0	6	5
99	R:R:S165	R:R:W166	4.94	No	Yes	3	5	8
100	R:R:L168	R:R:L172	4.15	No	No	0	4	5
101	R:R:L170	R:R:L174	5.54	No	No	0	4	5
102	R:R:L176	R:R:P177	4.93	No	No	0	5	8
103	R:R:P177	R:R:P193	9.74	No	No	0	8	5
104	R:R:H191	R:R:W179	7.41	No	No	0	4	3
105	R:R:H191	R:R:P193	10.68	No	No	0	4	5
106	R:R:A194	R:R:H191	4.39	No	No	0	4	4
107	R:R:P193	R:R:Y192	4.17	No	No	0	5	6
108	R:R:A194	R:R:S307	3.42	No	No	0	4	4
109	R:R:A198	R:R:L305	3.15	No	No	0	4	4
110	R:R:L201	R:R:T297	4.42	No	No	0	5	6
111	R:R:L201	R:R:L300	4.15	No	Yes	0	5	6
112	R:R:L201	R:R:V301	7.45	No	No	0	5	5
113	R:R:L202	R:R:V301	4.47	No	No	0	5	5
114	R:R:L208	R:R:Q204	3.99	Yes	Yes	1	8	7
115	R:R:F293	R:R:Q204	10.54	Yes	Yes	1	9	7
116	R:R:L209	R:R:T205	2.95	No	No	0	4	5
117	R:R:F293	R:R:T205	5.19	Yes	No	0	9	5
118	R:R:L294	R:R:T205	2.95	No	No	0	5	5
119	R:R:C211	R:R:L207	3.17	No	No	0	7	5
120	R:R:L208	R:R:Y212	5.86	Yes	Yes	1	8	9
121	R:R:F293	R:R:L208	8.53	Yes	Yes	1	9	8
122	R:R:C290	R:R:L209	3.17	No	No	0	8	4
123	R:R:V286	R:R:Y212	6.31	No	Yes	0	8	9
124	R:R:L289	R:R:Y212	8.21	No	Yes	0	8	9
125	R:R:C290	R:R:Y212	4.03	No	Yes	0	8	9
126	R:R:L213	W:W:?1	5.2	No	Yes	0	4	0
127	R:R:G214	R:R:R217	4.5	No	No	0	5	4
128	R:R:V216	W:W:?1	13.07	No	Yes	0	6	0
129	R:R:R218	R:R:R225	3.2	No	No	6	7	5
130	R:R:V219	W:W:?1	14	No	Yes	0	8	0
131	R:R:R220	W:W:?1	4.57	No	Yes	0	6	0
132	R:R:R280	R:R:S282	5.27	No	No	0	5	9
133	R:R:L281	R:R:L284	4.15	No	No	0	8	7
134	R:R:S282	W:W:?1	2.82	No	Yes	0	9	0
135	R:R:G283	W:W:?1	9.65	No	Yes	0	7	0
136	R:R:L284	R:R:W338	6.83	No	Yes	0	7	5
137	R:R:S285	R:R:W338	8.65	No	Yes	7	9	5
138	R:R:R339	R:R:S285	5.27	No	No	7	7	9
139	R:R:V286	W:W:?1	5.6	No	Yes	0	8	0
140	R:R:C291	R:R:L287	3.17	No	No	0	6	6
141	R:R:L287	W:W:?1	9.54	No	Yes	0	6	0
142	R:R:L288	R:R:W338	3.42	No	Yes	0	6	5
143	R:R:C290	W:W:?1	6.96	No	Yes	0	8	0
144	R:R:L335	R:R:V292	7.45	No	No	0	9	7
145	R:R:F293	R:R:T297	9.08	Yes	No	0	9	6
146	R:R:F293	R:R:L328	3.65	Yes	Yes	1	9	9
147	R:R:L294	R:R:Q298	3.99	No	No	0	5	6
148	R:R:A296	R:R:L328	6.3	No	Yes	0	8	9
149	R:R:Q298	R:R:V301	4.3	No	No	0	6	5
150	R:R:Q298	R:R:W302	12.05	No	No	0	6	5
151	R:R:L324	R:R:P299	3.28	No	No	0	6	9
152	R:R:L300	R:R:S304	3	Yes	No	0	6	7
153	R:R:L300	R:R:S321	3	Yes	Yes	5	6	6
154	R:R:L300	R:R:W322	7.97	Yes	No	5	6	4
155	R:R:C325	R:R:L300	4.76	No	Yes	0	6	6
156	R:R:Q318	R:R:V303	2.87	No	No	0	4	5
157	R:R:S321	R:R:V303	4.85	Yes	No	0	6	5
158	R:R:L311	R:R:P312	3.28	No	No	0	3	3
159	R:R:Q318	R:R:V313	10.03	No	No	0	4	5
160	R:R:S321	R:R:W322	4.94	Yes	No	5	6	4
161	R:R:L328	R:R:N332	4.12	Yes	Yes	1	9	9
162	R:R:N332	R:R:Y336	4.65	Yes	Yes	1	9	9
163	R:R:F343	R:R:T337	14.27	Yes	No	0	9	7
164	R:R:R339	R:R:W338	11	No	Yes	7	7	5
165	R:R:F343	R:R:N340	9.67	Yes	No	0	9	9
166	R:R:E341	R:R:R344	3.49	No	No	0	7	8
167	R:R:E342	R:R:R345	6.98	No	No	0	7	5
168	R:R:S349	R:R:V350	3.23	No	No	0	5	7
169	R:R:L351	R:R:V350	2.98	No	No	0	8	7
170	R:R:L120	R:R:L83	2.77	Yes	No	0	5	5
171	R:R:L122	R:R:L170	2.77	No	No	0	6	4
172	R:R:L164	R:R:L168	2.77	No	No	0	3	4
173	R:R:L172	R:R:L176	2.77	No	No	0	5	5
174	R:R:L176	R:R:L196	2.77	No	No	0	5	6
175	R:R:L284	R:R:L287	2.77	No	No	0	7	6
176	R:R:L288	R:R:L335	2.77	No	No	0	6	9
177	R:R:L289	R:R:L335	2.77	No	No	0	8	9
178	R:R:P178	R:R:W179	2.7	No	No	0	5	3
179	R:R:L62	R:R:Q63	2.66	No	Yes	0	9	8
180	R:R:F59	R:R:S58	2.64	No	No	0	8	6
181	R:R:F343	R:R:V52	2.62	Yes	No	0	9	9
182	R:R:F59	R:R:V350	2.62	No	No	0	8	7
183	R:R:R225	R:R:V221	2.62	No	No	0	5	4
184	R:R:A180	R:R:W322	2.59	No	No	0	6	4
185	R:R:F309	R:R:L195	2.44	No	No	0	4	5
186	R:R:F309	R:R:L311	2.44	No	No	0	4	3
187	R:R:E341	R:R:R345	2.33	No	No	0	7	5
188	R:R:L323	R:R:W84	2.28	No	No	0	5	6
189	R:R:L305	R:R:W302	2.28	No	No	0	4	5
190	R:R:Q318	R:R:W315	2.19	No	No	0	4	4
191	R:R:G44	R:R:G45	2.11	No	Yes	0	4	8
192	R:R:G117	R:R:G118	2.11	No	No	0	6	5
193	R:R:A48	R:R:G45	1.95	No	Yes	0	9	8
194	R:R:A330	R:R:G45	1.95	No	Yes	0	6	8
195	R:R:A159	R:R:G160	1.95	No	No	0	6	3
196	R:R:A194	R:R:G308	1.95	No	No	0	4	3
197	R:R:A145	R:R:P146	1.87	No	No	0	6	4
198	R:R:G123	R:R:S79	1.86	No	No	0	6	7
199	R:R:G123	R:R:V80	1.84	No	No	0	6	9
200	R:R:G118	R:R:V173	1.84	No	No	0	5	5
201	R:R:G121	R:R:V173	1.84	No	No	0	4	5
202	R:R:P299	R:R:S321	1.78	No	Yes	0	9	6
203	R:R:P314	R:R:V313	1.77	No	No	0	6	5
204	R:R:P314	R:R:V317	1.77	No	No	0	6	3
205	R:R:G44	R:R:I43	1.76	No	No	0	4	5
206	R:R:G44	R:R:L47	1.71	No	No	0	4	2
207	R:R:G50	R:R:L78	1.71	No	No	0	4	7
208	R:R:G117	R:R:L120	1.71	No	Yes	0	6	5
209	R:R:G121	R:R:L120	1.71	No	Yes	0	4	5
210	R:R:G123	R:R:L122	1.71	No	No	0	6	6
211	R:R:G171	R:R:L170	1.71	No	No	0	4	4
212	R:R:G171	R:R:L175	1.71	No	No	0	4	3
213	R:R:G308	R:R:L195	1.71	No	No	0	3	5
214	R:R:A306	R:R:V313	1.7	No	No	0	4	5
215	R:R:A68	R:R:T158	1.68	No	No	0	7	7
216	R:R:A145	R:R:T148	1.68	No	No	0	6	6
217	R:R:L351	R:R:P352	1.64	No	No	0	8	4
218	R:R:S57	R:R:S58	1.63	No	No	0	4	6
219	R:R:A75	R:R:I53	1.62	No	No	0	5	8
220	R:R:S227	R:R:V223	1.62	No	No	0	5	4
221	R:R:A42	R:R:M85	1.61	No	No	0	6	7
222	R:R:S66	R:R:T64	1.6	No	No	0	9	9
223	R:R:A327	R:R:L41	1.58	No	No	0	3	6
224	R:R:A330	R:R:L331	1.58	No	No	0	6	6
225	R:R:M51	R:R:V347	1.52	No	No	0	6	7
226	R:R:G117	R:R:R116	1.5	No	No	0	6	5
227	R:R:R218	R:R:S222	1.32	No	No	6	7	8
228	R:R:R225	R:R:S222	1.32	No	No	6	5	8
229	R:R:H157	R:R:M161	1.31	No	No	0	6	7
230	R:R:A319	R:R:W315	1.3	No	No	0	5	4
231	R:R:I142	R:R:R218	1.25	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:G45	2.4825	4	0	8
2	R:R:N49	7.165	4	0	9
3	R:R:Q63	5.22	4	4	8
4	R:R:F69	5.975	6	2	9
5	R:R:N72	8.1775	4	3	9
6	R:R:D77	9.065	4	1	9
7	R:R:L120	3.825	4	0	5
8	R:R:H131	8.475	6	1	9
9	R:R:N137	9.4325	4	2	9
10	R:R:Y139	5.68286	7	2	7
11	R:R:L140	5.1925	4	2	6
12	R:R:R144	5	4	2	7
13	R:R:Y153	7.31429	7	2	6
14	R:R:W166	8.71	4	3	8
15	R:R:Q204	6.5375	4	1	7
16	R:R:L208	5.078	5	1	8
17	R:R:Y212	6.33	6	1	9
18	R:R:F293	7.86167	6	1	9
19	R:R:L300	4.576	5	5	6
20	R:R:S321	3.6425	4	5	6
21	R:R:L328	4.8025	4	1	9
22	R:R:N332	7.65	5	1	9
23	R:R:Y336	9.87	4	1	9
24	R:R:W338	7.475	4	7	5
25	R:R:F343	7.22667	6	4	9
26	W:W:?1	7.93444	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A48	R:R:G45	16.5798	1.95	No	Yes	0	9	8
2	R:R:A48	R:R:P333	17.6659	3.74	No	No	0	9	9
3	R:R:N49	R:R:P333	46.1238	14.66	Yes	No	0	9	9
4	R:R:C74	R:R:N49	30.324	3.15	No	Yes	0	8	9
5	R:R:C74	R:R:V52	29.3108	6.83	No	No	0	8	9
6	R:R:P333	R:R:V52	30.9691	3.53	No	No	0	9	9
7	R:R:D77	R:R:N49	79.6661	6.73	Yes	Yes	0	9	9
8	R:R:F343	R:R:V52	57.9582	2.62	Yes	No	0	9	9
9	R:R:F343	R:R:L55	27.6561	4.87	Yes	No	0	9	8
10	R:R:F343	R:R:Q63	23.02	4.68	Yes	Yes	4	9	8
11	R:R:L55	R:R:S346	21.143	9.01	No	No	0	8	8
12	R:R:F59	R:R:S346	18.8249	10.57	No	No	0	8	8
13	R:R:L62	R:R:Q63	11.8162	2.66	No	Yes	0	9	8
14	R:R:D77	R:R:N332	100	14.81	Yes	Yes	1	9	9
15	R:R:H131	R:R:N332	87.382	10.2	Yes	Yes	1	9	9
16	R:R:H131	R:R:L208	37.5588	3.86	Yes	Yes	1	9	8
17	R:R:L208	R:R:Q204	32.5364	3.99	Yes	Yes	1	8	7
18	R:R:C132	R:R:Q204	84.3788	7.63	No	Yes	0	7	7
19	R:R:C132	R:R:L207	82.797	6.35	No	No	0	7	5
20	R:R:C211	R:R:L207	81.2079	3.17	No	No	0	7	5
21	R:R:C211	R:R:Y139	79.6115	6.72	No	Yes	0	7	7
22	R:R:L140	R:R:Y139	46.6961	3.52	Yes	Yes	2	6	7
23	R:R:L140	R:R:Y153	43.937	7.03	Yes	Yes	2	6	6
24	R:R:F69	R:R:Y153	24.2629	5.16	Yes	Yes	2	9	6
25	R:R:F293	R:R:H131	40.1465	10.18	Yes	Yes	1	9	9
26	R:R:F293	R:R:Q204	54.9805	10.54	Yes	Yes	1	9	7
27	R:R:L328	R:R:N332	37.8868	4.12	Yes	Yes	1	9	9
28	R:R:F293	R:R:L328	37.7556	3.65	Yes	Yes	1	9	9
29	R:R:F69	R:R:L162	15.2823	4.87	Yes	No	0	9	7
30	R:R:L162	R:R:N72	13.3652	10.98	No	Yes	0	7	9
31	R:R:C326	R:R:W84	26.3294	6.53	No	No	0	5	6
32	R:R:C326	R:R:V80	30.6885	3.42	No	No	0	5	9
33	R:R:S329	R:R:V80	54.904	8.08	No	No	0	9	9
34	R:R:S127	R:R:S329	25.6916	4.89	No	No	1	9	9
35	R:R:L120	R:R:W84	20.2245	9.11	Yes	No	0	5	6
36	R:R:G123	R:R:L122	18.7448	1.71	No	No	0	6	6
37	R:R:G123	R:R:V80	23.359	1.84	No	No	0	6	9
38	R:R:H131	R:R:L289	18.7994	5.14	Yes	No	0	9	8
39	R:R:L208	R:R:Y212	19.4919	5.86	Yes	Yes	1	8	9
40	R:R:L289	R:R:Y212	12.5524	8.21	No	Yes	0	8	9
41	R:R:T143	R:R:Y139	10.7009	12.48	No	Yes	2	8	7
42	R:R:I215	R:R:Y139	10.9123	3.63	No	Yes	0	9	7
43	R:R:L201	R:R:T297	25.1704	4.42	No	No	0	5	6
44	R:R:F293	R:R:T297	26.446	9.08	Yes	No	0	9	6
45	R:R:L201	R:R:L300	21.8391	4.15	No	Yes	0	5	6
46	R:R:C290	R:R:Y212	14.0613	4.03	No	Yes	0	8	9
47	R:R:V286	R:R:Y212	14.0905	6.31	No	Yes	0	8	9
48	R:R:V286	W:W:?1	12.8367	5.6	No	Yes	0	8	0
49	R:R:C290	W:W:?1	14.0649	6.96	No	Yes	0	8	0
50	R:R:I142	R:R:R218	14.5023	1.25	No	No	0	9	7
51	R:R:L300	R:R:S321	15.3916	3	Yes	Yes	5	6	6
52	R:R:S321	R:R:V303	11.3387	4.85	Yes	No	0	6	5
53	R:R:D77	R:R:S329	31.381	7.36	Yes	No	1	9	9
54	R:R:N332	R:R:S127	26.5882	4.47	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C290	R:R:L209	3.17	No	No	8	4	1	2
R:R:V286	R:R:Y212	6.31	No	Yes	8	9	1	2
R:R:C290	R:R:Y212	4.03	No	Yes	8	9	1	2
R:R:L213	W:W:?1	5.2	No	Yes	4	0	1	0
R:R:V216	W:W:?1	13.07	No	Yes	6	0	1	0
R:R:V219	W:W:?1	14	No	Yes	8	0	1	0
R:R:R220	W:W:?1	4.57	No	Yes	6	0	1	0
R:R:R280	R:R:S282	5.27	No	No	5	9	2	1
R:R:S282	W:W:?1	2.82	No	Yes	9	0	1	0
R:R:G283	W:W:?1	9.65	No	Yes	7	0	1	0
R:R:V286	W:W:?1	5.6	No	Yes	8	0	1	0
R:R:C291	R:R:L287	3.17	No	No	6	6	2	1
R:R:L287	W:W:?1	9.54	No	Yes	6	0	1	0
R:R:C290	W:W:?1	6.96	No	Yes	8	0	1	0
R:R:L284	R:R:L287	2.77	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EJX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.82
Number of Linked Nodes	204
Number of Links	231
Number of Hubs	26
Number of Links mediated by Hubs	104
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	46918
Length Of Smallest Path	3
Average Path Length	14.5033
Length of Longest Path	26
Minimum Path Strength	1.605
Average Path Strength	6.21868
Maximum Path Strength	13.665
Minimum Path Correlation	0.7
Average Path Correlation	0.915296
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	39.476
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.698
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J5F
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J5F
Name	(1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide
Synonyms
Identifier
Formula	C30 H37 N3 O
Molecular Weight	455.634
SMILES
PubChem	58466521
Formal Charge	0
Total Atoms	71
Total Chiral Atoms	4
Total Bonds	74
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZN0
Sequence	>7EJX_nogp_Chain_R L Y S G L A I G G T L A N G M V I Y L V S S F R K L Q T T S N A F I V N G C A A D L S V C A L W M P R L L R G G L L G L G L T V S L L S H C L V A L N R Y L L I T R A P A T Y Q A L Y Q R R H T A G M L A L S W A L A L G L V L L L P P W A H Y P A L L A A A A L L A Q T A L L L H C Y L G I V R R V R V S V K R V S V R L S G L S V L L L C C V F L L A T Q P L V W V S L A S G F S L P V P W G V Q A A S W L L C C A L S A L N P L L Y T W R N E E F R R S V R S V L P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EJX	A	Orphan	Orphan	GPR88	Homo sapiens	-	(1R;2R)-2-PCCA	Gi1/β1/γ2	2.4	2022-04-13	doi.org/10.1038/s41467-022-30081-5
	7EJX (No Gprot)	A	Orphan	Orphan	GPR88	Homo sapiens	-	(1R;2R)-2-PCCA		2.4	2022-04-13	doi.org/10.1038/s41467-022-30081-5
	7WZ4	A	Orphan	Orphan	GPR88	Homo sapiens	-	-	Gi1/β1/γ2	3	2022-10-26	doi.org/10.1038/s41467-022-30081-5
	7WZ4 (No Gprot)	A	Orphan	Orphan	GPR88	Homo sapiens	-	-		3	2022-10-26	doi.org/10.1038/s41467-022-30081-5

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EJX_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.