psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L41	R:R:Y38	3.52	No	No	0	6	4
2	R:R:L323	R:R:Y38	12.89	No	No	0	5	4
3	R:R:P86	R:R:S39	8.91	No	No	0	9	4
4	R:R:G40	R:R:I43	3.53	No	No	0	5	5
5	R:R:A330	R:R:L41	3.15	No	No	0	6	6
6	R:R:I43	R:R:M85	2.92	No	No	0	5	7
7	R:R:C81	R:R:G45	3.92	No	Yes	0	7	8
8	R:R:L78	R:R:T46	4.42	No	No	0	7	6
9	R:R:A48	R:R:P333	3.74	No	No	0	9	9
10	R:R:C74	R:R:N49	3.15	No	Yes	0	8	9
11	R:R:D77	R:R:N49	6.73	Yes	Yes	0	9	9
12	R:R:L78	R:R:N49	4.12	No	Yes	0	7	9
13	R:R:N49	R:R:P333	14.66	Yes	No	0	9	9
14	R:R:L55	R:R:M51	2.83	No	No	0	8	6
15	R:R:C74	R:R:V52	6.83	No	No	0	8	9
16	R:R:P333	R:R:V52	3.53	No	No	0	9	9
17	R:R:I53	R:R:V71	4.61	No	No	0	8	8
18	R:R:S58	R:R:Y54	10.17	No	No	0	6	5
19	R:R:F343	R:R:L55	4.87	Yes	No	0	9	8
20	R:R:L55	R:R:S346	9.01	No	No	0	8	8
21	R:R:Q63	R:R:V56	4.3	Yes	No	0	8	9
22	R:R:V56	R:R:V71	11.22	No	No	0	9	8
23	R:R:F59	R:R:S346	10.57	No	No	0	8	8
24	R:R:E342	R:R:L62	11.93	No	No	0	7	9
25	R:R:N67	R:R:Q63	9.24	No	Yes	4	9	8
26	R:R:F343	R:R:Q63	4.68	Yes	Yes	4	9	8
27	R:R:T158	R:R:T65	4.71	No	No	0	7	6
28	R:R:N137	R:R:S66	5.96	Yes	No	0	9	9
29	R:R:F343	R:R:N67	7.25	Yes	No	4	9	9
30	R:R:F69	R:R:L133	8.53	Yes	No	0	9	5
31	R:R:F69	R:R:N137	9.67	Yes	Yes	2	9	9
32	R:R:F69	R:R:Y153	5.16	Yes	Yes	2	9	6
33	R:R:F69	R:R:T158	3.89	Yes	No	0	9	7
34	R:R:F69	R:R:M161	3.73	Yes	No	2	9	7
35	R:R:F69	R:R:L162	4.87	Yes	No	0	9	7
36	R:R:I70	R:R:V134	3.07	No	No	1	9	9
37	R:R:I70	R:R:Y336	9.67	No	Yes	1	9	9
38	R:R:N72	R:R:S130	5.96	Yes	No	0	9	8
39	R:R:L162	R:R:N72	10.98	No	Yes	0	7	9
40	R:R:N72	R:R:S165	4.47	Yes	No	3	9	5
41	R:R:N72	R:R:W166	11.3	Yes	Yes	3	9	8
42	R:R:G73	R:R:S130	3.71	No	No	0	9	8
43	R:R:A76	R:R:V126	3.39	No	No	3	8	8
44	R:R:A76	R:R:W166	3.89	No	Yes	3	8	8
45	R:R:D77	R:R:S127	7.36	Yes	No	1	9	9
46	R:R:D77	R:R:S329	7.36	Yes	No	1	9	9
47	R:R:D77	R:R:N332	14.81	Yes	Yes	1	9	9
48	R:R:C326	R:R:V80	3.42	No	No	0	5	9
49	R:R:S329	R:R:V80	8.08	No	No	0	9	9
50	R:R:L119	R:R:L83	6.92	No	No	0	5	5
51	R:R:L120	R:R:W84	9.11	Yes	No	0	5	6
52	R:R:C326	R:R:W84	6.53	No	No	0	5	6
53	R:R:M85	R:R:P86	3.35	No	No	0	7	9
54	R:R:R113	R:R:R116	4.26	No	No	0	8	5
55	R:R:A169	R:R:L122	3.15	No	No	0	7	6
56	R:R:C326	R:R:L124	3.17	No	No	0	5	6
57	R:R:L129	R:R:T125	2.95	No	No	0	4	7
58	R:R:A169	R:R:T125	5.03	No	No	0	7	7
59	R:R:V126	R:R:W166	14.71	No	Yes	3	8	8
60	R:R:S127	R:R:S329	4.89	No	No	1	9	9
61	R:R:N332	R:R:S127	4.47	Yes	No	1	9	9
62	R:R:L128	R:R:Q204	3.99	No	Yes	0	7	7
63	R:R:H131	R:R:L208	3.86	Yes	Yes	1	9	8
64	R:R:H131	R:R:L289	5.14	Yes	No	0	9	8
65	R:R:F293	R:R:H131	10.18	Yes	Yes	1	9	9
66	R:R:H131	R:R:L328	5.14	Yes	Yes	1	9	9
67	R:R:H131	R:R:N332	10.2	Yes	Yes	1	9	9
68	R:R:H131	R:R:Y336	16.33	Yes	Yes	1	9	9
69	R:R:C132	R:R:Q204	7.63	No	Yes	0	7	7
70	R:R:C132	R:R:L207	6.35	No	No	0	7	5
71	R:R:R138	R:R:V134	6.54	No	No	0	9	9
72	R:R:V134	R:R:Y336	8.83	No	Yes	1	9	9
73	R:R:A135	R:R:L208	3.15	No	Yes	1	8	8
74	R:R:A135	R:R:Y212	5.34	No	Yes	1	8	9
75	R:R:L136	R:R:L140	4.15	No	Yes	2	6	6
76	R:R:L136	R:R:Y153	3.52	No	Yes	2	6	6
77	R:R:N137	R:R:Y149	6.98	Yes	No	2	9	9
78	R:R:N137	R:R:Y153	15.12	Yes	Yes	2	9	6
79	R:R:R138	R:R:Y212	8.23	No	Yes	0	9	9
80	R:R:L140	R:R:Y139	3.52	Yes	Yes	2	6	7
81	R:R:T143	R:R:Y139	12.48	No	Yes	2	8	7
82	R:R:R144	R:R:Y139	6.17	Yes	Yes	2	7	7
83	R:R:H210	R:R:Y139	4.36	No	Yes	0	4	7
84	R:R:C211	R:R:Y139	6.72	No	Yes	0	7	7
85	R:R:G214	R:R:Y139	2.9	No	Yes	0	5	7
86	R:R:I215	R:R:Y139	3.63	No	Yes	0	9	7
87	R:R:L140	R:R:R144	6.07	Yes	Yes	2	6	7
88	R:R:L140	R:R:Y153	7.03	Yes	Yes	2	6	6
89	R:R:L141	R:R:Y149	16.41	No	No	0	8	9
90	R:R:I142	R:R:T143	3.04	No	No	0	9	8
91	R:R:I142	R:R:I215	5.89	No	No	0	9	9
92	R:R:R144	R:R:T143	3.88	Yes	No	2	7	8
93	R:R:R144	R:R:T148	3.88	Yes	No	0	7	6
94	R:R:Y149	R:R:Y153	10.92	No	Yes	2	9	6
95	R:R:L152	R:R:Y153	5.86	No	Yes	0	5	6
96	R:R:M161	R:R:Y153	3.59	No	Yes	2	7	6
97	R:R:H157	R:R:Q154	6.18	No	No	0	6	8
98	R:R:H157	R:R:R156	5.64	No	No	0	6	5
99	R:R:S165	R:R:W166	4.94	No	Yes	3	5	8
100	R:R:L168	R:R:L172	4.15	No	No	0	4	5
101	R:R:L170	R:R:L174	5.54	No	No	0	4	5
102	R:R:L176	R:R:P177	4.93	No	No	0	5	8
103	R:R:P177	R:R:P193	9.74	No	No	0	8	5
104	R:R:H191	R:R:W179	7.41	No	No	0	4	3
105	R:R:H191	R:R:P193	10.68	No	No	0	4	5
106	R:R:A194	R:R:H191	4.39	No	No	0	4	4
107	R:R:P193	R:R:Y192	4.17	No	No	0	5	6
108	R:R:A194	R:R:S307	3.42	No	No	0	4	4
109	R:R:A198	R:R:L305	3.15	No	No	0	4	4
110	R:R:L201	R:R:T297	4.42	No	No	0	5	6
111	R:R:L201	R:R:L300	4.15	No	Yes	0	5	6
112	R:R:L201	R:R:V301	7.45	No	No	0	5	5
113	R:R:L202	R:R:V301	4.47	No	No	0	5	5
114	R:R:L208	R:R:Q204	3.99	Yes	Yes	1	8	7
115	R:R:F293	R:R:Q204	10.54	Yes	Yes	1	9	7
116	R:R:L209	R:R:T205	2.95	No	No	0	4	5
117	R:R:F293	R:R:T205	5.19	Yes	No	0	9	5
118	R:R:L294	R:R:T205	2.95	No	No	0	5	5
119	R:R:C211	R:R:L207	3.17	No	No	0	7	5
120	R:R:L208	R:R:Y212	5.86	Yes	Yes	1	8	9
121	R:R:F293	R:R:L208	8.53	Yes	Yes	1	9	8
122	R:R:C290	R:R:L209	3.17	No	No	0	8	4
123	R:R:V286	R:R:Y212	6.31	No	Yes	0	8	9
124	R:R:L289	R:R:Y212	8.21	No	Yes	0	8	9
125	R:R:C290	R:R:Y212	4.03	No	Yes	0	8	9
126	R:R:L213	W:W:?1	5.2	No	Yes	0	4	0
127	R:R:G214	R:R:R217	4.5	No	No	0	5	4
128	R:R:V216	W:W:?1	13.07	No	Yes	0	6	0
129	R:R:R218	R:R:R225	3.2	No	No	6	7	5
130	R:R:V219	W:W:?1	14	No	Yes	0	8	0
131	R:R:R220	W:W:?1	4.57	No	Yes	0	6	0
132	R:R:R280	R:R:S282	5.27	No	No	0	5	9
133	R:R:L281	R:R:L284	4.15	No	No	0	8	7
134	R:R:S282	W:W:?1	2.82	No	Yes	0	9	0
135	R:R:G283	W:W:?1	9.65	No	Yes	0	7	0
136	R:R:L284	R:R:W338	6.83	No	Yes	0	7	5
137	R:R:S285	R:R:W338	8.65	No	Yes	7	9	5
138	R:R:R339	R:R:S285	5.27	No	No	7	7	9
139	R:R:V286	W:W:?1	5.6	No	Yes	0	8	0
140	R:R:C291	R:R:L287	3.17	No	No	0	6	6
141	R:R:L287	W:W:?1	9.54	No	Yes	0	6	0
142	R:R:L288	R:R:W338	3.42	No	Yes	0	6	5
143	R:R:C290	W:W:?1	6.96	No	Yes	0	8	0
144	R:R:L335	R:R:V292	7.45	No	No	0	9	7
145	R:R:F293	R:R:T297	9.08	Yes	No	0	9	6
146	R:R:F293	R:R:L328	3.65	Yes	Yes	1	9	9
147	R:R:L294	R:R:Q298	3.99	No	No	0	5	6
148	R:R:A296	R:R:L328	6.3	No	Yes	0	8	9
149	R:R:Q298	R:R:V301	4.3	No	No	0	6	5
150	R:R:Q298	R:R:W302	12.05	No	No	0	6	5
151	R:R:L324	R:R:P299	3.28	No	No	0	6	9
152	R:R:L300	R:R:S304	3	Yes	No	0	6	7
153	R:R:L300	R:R:S321	3	Yes	Yes	5	6	6
154	R:R:L300	R:R:W322	7.97	Yes	No	5	6	4
155	R:R:C325	R:R:L300	4.76	No	Yes	0	6	6
156	R:R:Q318	R:R:V303	2.87	No	No	0	4	5
157	R:R:S321	R:R:V303	4.85	Yes	No	0	6	5
158	R:R:L311	R:R:P312	3.28	No	No	0	3	3
159	R:R:Q318	R:R:V313	10.03	No	No	0	4	5
160	R:R:S321	R:R:W322	4.94	Yes	No	5	6	4
161	R:R:L328	R:R:N332	4.12	Yes	Yes	1	9	9
162	R:R:N332	R:R:Y336	4.65	Yes	Yes	1	9	9
163	R:R:F343	R:R:T337	14.27	Yes	No	0	9	7
164	R:R:R339	R:R:W338	11	No	Yes	7	7	5
165	R:R:F343	R:R:N340	9.67	Yes	No	0	9	9
166	R:R:E341	R:R:R344	3.49	No	No	0	7	8
167	R:R:E342	R:R:R345	6.98	No	No	0	7	5
168	R:R:S349	R:R:V350	3.23	No	No	0	5	7
169	R:R:L351	R:R:V350	2.98	No	No	0	8	7
170	R:R:L120	R:R:L83	2.77	Yes	No	0	5	5
171	R:R:L122	R:R:L170	2.77	No	No	0	6	4
172	R:R:L164	R:R:L168	2.77	No	No	0	3	4
173	R:R:L172	R:R:L176	2.77	No	No	0	5	5
174	R:R:L176	R:R:L196	2.77	No	No	0	5	6
175	R:R:L284	R:R:L287	2.77	No	No	0	7	6
176	R:R:L288	R:R:L335	2.77	No	No	0	6	9
177	R:R:L289	R:R:L335	2.77	No	No	0	8	9
178	R:R:P178	R:R:W179	2.7	No	No	0	5	3
179	R:R:L62	R:R:Q63	2.66	No	Yes	0	9	8
180	R:R:F59	R:R:S58	2.64	No	No	0	8	6
181	R:R:F343	R:R:V52	2.62	Yes	No	0	9	9
182	R:R:F59	R:R:V350	2.62	No	No	0	8	7
183	R:R:R225	R:R:V221	2.62	No	No	0	5	4
184	R:R:A180	R:R:W322	2.59	No	No	0	6	4
185	R:R:F309	R:R:L195	2.44	No	No	0	4	5
186	R:R:F309	R:R:L311	2.44	No	No	0	4	3
187	R:R:E341	R:R:R345	2.33	No	No	0	7	5
188	R:R:L323	R:R:W84	2.28	No	No	0	5	6
189	R:R:L305	R:R:W302	2.28	No	No	0	4	5
190	R:R:Q318	R:R:W315	2.19	No	No	0	4	4
191	R:R:G44	R:R:G45	2.11	No	Yes	0	4	8
192	R:R:G117	R:R:G118	2.11	No	No	0	6	5
193	R:R:A48	R:R:G45	1.95	No	Yes	0	9	8
194	R:R:A330	R:R:G45	1.95	No	Yes	0	6	8
195	R:R:A159	R:R:G160	1.95	No	No	0	6	3
196	R:R:A194	R:R:G308	1.95	No	No	0	4	3
197	R:R:A145	R:R:P146	1.87	No	No	0	6	4
198	R:R:G123	R:R:S79	1.86	No	No	0	6	7
199	R:R:G123	R:R:V80	1.84	No	No	0	6	9
200	R:R:G118	R:R:V173	1.84	No	No	0	5	5
201	R:R:G121	R:R:V173	1.84	No	No	0	4	5
202	R:R:P299	R:R:S321	1.78	No	Yes	0	9	6
203	R:R:P314	R:R:V313	1.77	No	No	0	6	5
204	R:R:P314	R:R:V317	1.77	No	No	0	6	3
205	R:R:G44	R:R:I43	1.76	No	No	0	4	5
206	R:R:G44	R:R:L47	1.71	No	No	0	4	2
207	R:R:G50	R:R:L78	1.71	No	No	0	4	7
208	R:R:G117	R:R:L120	1.71	No	Yes	0	6	5
209	R:R:G121	R:R:L120	1.71	No	Yes	0	4	5
210	R:R:G123	R:R:L122	1.71	No	No	0	6	6
211	R:R:G171	R:R:L170	1.71	No	No	0	4	4
212	R:R:G171	R:R:L175	1.71	No	No	0	4	3
213	R:R:G308	R:R:L195	1.71	No	No	0	3	5
214	R:R:A306	R:R:V313	1.7	No	No	0	4	5
215	R:R:A68	R:R:T158	1.68	No	No	0	7	7
216	R:R:A145	R:R:T148	1.68	No	No	0	6	6
217	R:R:L351	R:R:P352	1.64	No	No	0	8	4
218	R:R:S57	R:R:S58	1.63	No	No	0	4	6
219	R:R:A75	R:R:I53	1.62	No	No	0	5	8
220	R:R:S227	R:R:V223	1.62	No	No	0	5	4
221	R:R:A42	R:R:M85	1.61	No	No	0	6	7
222	R:R:S66	R:R:T64	1.6	No	No	0	9	9
223	R:R:A327	R:R:L41	1.58	No	No	0	3	6
224	R:R:A330	R:R:L331	1.58	No	No	0	6	6
225	R:R:M51	R:R:V347	1.52	No	No	0	6	7
226	R:R:G117	R:R:R116	1.5	No	No	0	6	5
227	R:R:R218	R:R:S222	1.32	No	No	6	7	8
228	R:R:R225	R:R:S222	1.32	No	No	6	5	8
229	R:R:H157	R:R:M161	1.31	No	No	0	6	7
230	R:R:A319	R:R:W315	1.3	No	No	0	5	4
231	R:R:I142	R:R:R218	1.25	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:G45	2.4825	4	0	8
2	R:R:N49	7.165	4	0	9
3	R:R:Q63	5.22	4	4	8
4	R:R:F69	5.975	6	2	9
5	R:R:N72	8.1775	4	3	9
6	R:R:D77	9.065	4	1	9
7	R:R:L120	3.825	4	0	5
8	R:R:H131	8.475	6	1	9
9	R:R:N137	9.4325	4	2	9
10	R:R:Y139	5.68286	7	2	7
11	R:R:L140	5.1925	4	2	6
12	R:R:R144	5	4	2	7
13	R:R:Y153	7.31429	7	2	6
14	R:R:W166	8.71	4	3	8
15	R:R:Q204	6.5375	4	1	7
16	R:R:L208	5.078	5	1	8
17	R:R:Y212	6.33	6	1	9
18	R:R:F293	7.86167	6	1	9
19	R:R:L300	4.576	5	5	6
20	R:R:S321	3.6425	4	5	6
21	R:R:L328	4.8025	4	1	9
22	R:R:N332	7.65	5	1	9
23	R:R:Y336	9.87	4	1	9
24	R:R:W338	7.475	4	7	5
25	R:R:F343	7.22667	6	4	9
26	W:W:?1	7.93444	9	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A48	R:R:G45	16.5798	1.95	No	Yes	0	9	8
2	R:R:A48	R:R:P333	17.6659	3.74	No	No	0	9	9
3	R:R:N49	R:R:P333	46.1238	14.66	Yes	No	0	9	9
4	R:R:C74	R:R:N49	30.324	3.15	No	Yes	0	8	9
5	R:R:C74	R:R:V52	29.3108	6.83	No	No	0	8	9
6	R:R:P333	R:R:V52	30.9691	3.53	No	No	0	9	9
7	R:R:D77	R:R:N49	79.6661	6.73	Yes	Yes	0	9	9
8	R:R:F343	R:R:V52	57.9582	2.62	Yes	No	0	9	9
9	R:R:F343	R:R:L55	27.6561	4.87	Yes	No	0	9	8
10	R:R:F343	R:R:Q63	23.02	4.68	Yes	Yes	4	9	8
11	R:R:L55	R:R:S346	21.143	9.01	No	No	0	8	8
12	R:R:F59	R:R:S346	18.8249	10.57	No	No	0	8	8
13	R:R:L62	R:R:Q63	11.8162	2.66	No	Yes	0	9	8
14	R:R:D77	R:R:N332	100	14.81	Yes	Yes	1	9	9
15	R:R:H131	R:R:N332	87.382	10.2	Yes	Yes	1	9	9
16	R:R:H131	R:R:L208	37.5588	3.86	Yes	Yes	1	9	8
17	R:R:L208	R:R:Q204	32.5364	3.99	Yes	Yes	1	8	7
18	R:R:C132	R:R:Q204	84.3788	7.63	No	Yes	0	7	7
19	R:R:C132	R:R:L207	82.797	6.35	No	No	0	7	5
20	R:R:C211	R:R:L207	81.2079	3.17	No	No	0	7	5
21	R:R:C211	R:R:Y139	79.6115	6.72	No	Yes	0	7	7
22	R:R:L140	R:R:Y139	46.6961	3.52	Yes	Yes	2	6	7
23	R:R:L140	R:R:Y153	43.937	7.03	Yes	Yes	2	6	6
24	R:R:F69	R:R:Y153	24.2629	5.16	Yes	Yes	2	9	6
25	R:R:F293	R:R:H131	40.1465	10.18	Yes	Yes	1	9	9
26	R:R:F293	R:R:Q204	54.9805	10.54	Yes	Yes	1	9	7
27	R:R:L328	R:R:N332	37.8868	4.12	Yes	Yes	1	9	9
28	R:R:F293	R:R:L328	37.7556	3.65	Yes	Yes	1	9	9
29	R:R:F69	R:R:L162	15.2823	4.87	Yes	No	0	9	7
30	R:R:L162	R:R:N72	13.3652	10.98	No	Yes	0	7	9
31	R:R:C326	R:R:W84	26.3294	6.53	No	No	0	5	6
32	R:R:C326	R:R:V80	30.6885	3.42	No	No	0	5	9
33	R:R:S329	R:R:V80	54.904	8.08	No	No	0	9	9
34	R:R:S127	R:R:S329	25.6916	4.89	No	No	1	9	9
35	R:R:L120	R:R:W84	20.2245	9.11	Yes	No	0	5	6
36	R:R:G123	R:R:L122	18.7448	1.71	No	No	0	6	6
37	R:R:G123	R:R:V80	23.359	1.84	No	No	0	6	9
38	R:R:H131	R:R:L289	18.7994	5.14	Yes	No	0	9	8
39	R:R:L208	R:R:Y212	19.4919	5.86	Yes	Yes	1	8	9
40	R:R:L289	R:R:Y212	12.5524	8.21	No	Yes	0	8	9
41	R:R:T143	R:R:Y139	10.7009	12.48	No	Yes	2	8	7
42	R:R:I215	R:R:Y139	10.9123	3.63	No	Yes	0	9	7
43	R:R:L201	R:R:T297	25.1704	4.42	No	No	0	5	6
44	R:R:F293	R:R:T297	26.446	9.08	Yes	No	0	9	6
45	R:R:L201	R:R:L300	21.8391	4.15	No	Yes	0	5	6
46	R:R:C290	R:R:Y212	14.0613	4.03	No	Yes	0	8	9
47	R:R:V286	R:R:Y212	14.0905	6.31	No	Yes	0	8	9
48	R:R:V286	W:W:?1	12.8367	5.6	No	Yes	0	8	0
49	R:R:C290	W:W:?1	14.0649	6.96	No	Yes	0	8	0
50	R:R:I142	R:R:R218	14.5023	1.25	No	No	0	9	7
51	R:R:L300	R:R:S321	15.3916	3	Yes	Yes	5	6	6
52	R:R:S321	R:R:V303	11.3387	4.85	Yes	No	0	6	5
53	R:R:D77	R:R:S329	31.381	7.36	Yes	No	1	9	9
54	R:R:N332	R:R:S127	26.5882	4.47	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C290	R:R:L209	3.17	No	No	8	4	1	2
R:R:V286	R:R:Y212	6.31	No	Yes	8	9	1	2
R:R:C290	R:R:Y212	4.03	No	Yes	8	9	1	2
R:R:L213	W:W:?1	5.2	No	Yes	4	0	1	0
R:R:V216	W:W:?1	13.07	No	Yes	6	0	1	0
R:R:V219	W:W:?1	14	No	Yes	8	0	1	0
R:R:R220	W:W:?1	4.57	No	Yes	6	0	1	0
R:R:R280	R:R:S282	5.27	No	No	5	9	2	1
R:R:S282	W:W:?1	2.82	No	Yes	9	0	1	0
R:R:G283	W:W:?1	9.65	No	Yes	7	0	1	0
R:R:V286	W:W:?1	5.6	No	Yes	8	0	1	0
R:R:C291	R:R:L287	3.17	No	No	6	6	2	1
R:R:L287	W:W:?1	9.54	No	Yes	6	0	1	0
R:R:C290	W:W:?1	6.96	No	Yes	8	0	1	0
R:R:L284	R:R:L287	2.77	No	No	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EJX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.82
Number of Linked Nodes	204
Number of Links	231
Number of Hubs	26
Number of Links mediated by Hubs	104
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	46918
Length Of Smallest Path	3
Average Path Length	14.5033
Length of Longest Path	26
Minimum Path Strength	1.605
Average Path Strength	6.21868
Maximum Path Strength	13.665
Minimum Path Correlation	0.7
Average Path Correlation	0.915287
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	39.45
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.698
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • nervous system process • biological regulation • action potential • transmission of nerve impulse • cell communication • neuronal action potential • cellular process • regulation of biological quality • regulation of membrane potential • behavior • locomotory behavior • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • phototransduction • detection of light stimulus • detection of external stimulus • regulation of biological process • regulation of cellular process • signaling • response to external stimulus • detection of abiotic stimulus • detection of stimulus • signal transduction • G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • learning • learning or memory • motor learning • cognition • neuromuscular process • neuromuscular process controlling balance • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • intracellular organelle • nucleus • intracellular membrane-bounded organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • intracellular organelle • nucleus • intracellular membrane-bounded organelle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J5F
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	J5F
Name	(1R,2R)-N-[(2S,3S)-2-azanyl-3-methyl-pentyl]-N-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide
Synonyms
Identifier
Formula	C30 H37 N3 O
Molecular Weight	455.634
SMILES
PubChem	58466521
Formal Charge	0
Total Atoms	71
Total Chiral Atoms	4
Total Bonds	74
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZN0
Sequence	>7EJX_nogp_Chain_R L Y S G L A I G G T L A N G M V I Y L V S S F R K L Q T T S N A F I V N G C A A D L S V C A L W M P R L L R G G L L G L G L T V S L L S H C L V A L N R Y L L I T R A P A T Y Q A L Y Q R R H T A G M L A L S W A L A L G L V L L L P P W A H Y P A L L A A A A L L A Q T A L L L H C Y L G I V R R V R V S V K R V S V R L S G L S V L L L C C V F L L A T Q P L V W V S L A S G F S L P V P W G V Q A A S W L L C C A L S A L N P L L Y T W R N E E F R R S V R S V L P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WZ4	A	Orphan	Orphan	GPR88	Homo sapiens	-	-	Gi1/β1/γ2	3	2022-10-26	10.1038/s41467-022-30081-5
	7WZ4 (No Gprot)	A	Orphan	Orphan	GPR88	Homo sapiens	-	-		3	2022-10-26	10.1038/s41467-022-30081-5
	7EJX	A	Orphan	Orphan	GPR88	Homo sapiens	-	(1R;2R)-2-PCCA	Gi1/β1/γ2	2.4	2022-04-13	10.1038/s41467-022-30081-5
	7EJX (No Gprot)	A	Orphan	Orphan	GPR88	Homo sapiens	-	(1R;2R)-2-PCCA		2.4	2022-04-13	10.1038/s41467-022-30081-5

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EJX_nogp.zip

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