psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L323	R:R:L37	2.77	No	No	0	5	4
2	R:R:M85	R:R:Y38	20.35	Yes	No	1	7	4
3	R:R:L323	R:R:Y38	11.72	No	No	0	5	4
4	R:R:C326	R:R:Y38	6.72	No	No	1	5	4
5	R:R:G40	R:R:S39	3.71	No	No	0	5	4
6	R:R:A327	R:R:L41	3.15	No	No	0	3	6
7	R:R:A330	R:R:L41	4.73	No	No	0	6	6
8	R:R:A42	R:R:M85	3.22	No	Yes	0	6	7
9	R:R:A42	R:R:P86	3.74	No	No	0	6	9
10	R:R:G44	R:R:I43	3.53	No	No	0	4	5
11	R:R:L78	R:R:T46	2.95	No	No	0	7	6
12	R:R:A48	R:R:P333	3.74	No	No	0	9	9
13	R:R:D77	R:R:N49	5.39	No	Yes	0	9	9
14	R:R:L78	R:R:N49	9.61	No	Yes	0	7	9
15	R:R:N49	R:R:P333	8.15	Yes	No	0	9	9
16	R:R:L55	R:R:M51	2.83	Yes	No	0	8	6
17	R:R:C74	R:R:V52	3.42	No	No	0	8	9
18	R:R:P333	R:R:V52	3.53	No	No	0	9	9
19	R:R:S58	R:R:Y54	8.9	No	No	0	6	5
20	R:R:F59	R:R:L55	2.44	Yes	Yes	0	8	8
21	R:R:F343	R:R:L55	3.65	Yes	Yes	0	9	8
22	R:R:L55	R:R:V347	2.98	Yes	No	0	8	7
23	R:R:Q63	R:R:V56	2.87	No	No	0	8	9
24	R:R:V56	R:R:V71	4.81	No	No	0	9	8
25	R:R:F343	R:R:V56	2.62	Yes	No	0	9	9
26	R:R:F59	R:R:S346	11.89	Yes	No	0	8	8
27	R:R:F59	R:R:V350	2.62	Yes	No	0	8	7
28	R:R:K61	R:R:L62	5.64	No	No	0	7	9
29	R:R:E342	R:R:L62	14.58	No	No	0	7	9
30	R:R:N67	R:R:Q63	13.2	No	No	0	9	8
31	R:R:T65	R:R:Y149	2.5	No	Yes	0	6	9
32	R:R:T158	R:R:T65	3.14	Yes	No	0	7	6
33	R:R:N137	R:R:S66	7.45	Yes	No	0	9	9
34	R:R:I70	R:R:N67	2.83	No	No	0	9	9
35	R:R:F343	R:R:N67	7.25	Yes	No	0	9	9
36	R:R:F69	R:R:L133	8.53	Yes	No	0	9	5
37	R:R:F69	R:R:N137	7.25	Yes	Yes	3	9	9
38	R:R:F69	R:R:Y153	4.13	Yes	Yes	3	9	6
39	R:R:F69	R:R:T158	2.59	Yes	Yes	3	9	7
40	R:R:F69	R:R:L162	2.44	Yes	No	3	9	7
41	R:R:I70	R:R:T337	3.04	No	No	0	9	7
42	R:R:L162	R:R:N72	6.87	No	No	0	7	9
43	R:R:N72	R:R:W166	6.78	No	No	0	9	8
44	R:R:G73	R:R:S130	3.71	No	No	0	9	8
45	R:R:A76	R:R:V126	3.39	No	Yes	0	8	8
46	R:R:D77	R:R:S127	7.36	No	No	2	9	9
47	R:R:D77	R:R:N332	13.46	No	Yes	2	9	9
48	R:R:V80	R:R:W84	2.45	Yes	Yes	1	9	6
49	R:R:G123	R:R:V80	3.68	No	Yes	0	6	9
50	R:R:L124	R:R:V80	5.96	No	Yes	1	6	9
51	R:R:S329	R:R:V80	6.46	No	Yes	0	9	9
52	R:R:C81	R:R:M85	3.24	No	Yes	0	7	7
53	R:R:L119	R:R:L83	4.15	No	No	0	5	5
54	R:R:L120	R:R:L83	2.77	No	No	0	5	5
55	R:R:M85	R:R:W84	3.49	Yes	Yes	1	7	6
56	R:R:L120	R:R:W84	29.61	No	Yes	0	5	6
57	R:R:L124	R:R:W84	5.69	No	Yes	1	6	6
58	R:R:W322	R:R:W84	10.31	Yes	Yes	1	4	6
59	R:R:C326	R:R:W84	9.14	No	Yes	1	5	6
60	R:R:C326	R:R:M85	3.24	No	Yes	1	5	7
61	R:R:Q87	R:R:R116	8.18	No	No	0	5	5
62	R:R:L119	R:R:R113	2.43	No	No	0	5	8
63	R:R:R113	R:R:V173	2.62	No	No	0	8	5
64	R:R:L174	R:R:R113	2.43	No	No	0	5	8
65	R:R:L120	R:R:R116	4.86	No	No	0	5	5
66	R:R:L122	R:R:V126	2.98	No	Yes	0	6	8
67	R:R:L122	R:R:V173	2.98	No	No	0	6	5
68	R:R:L124	R:R:W322	3.42	No	Yes	1	6	4
69	R:R:V126	R:R:W166	12.26	Yes	No	0	8	8
70	R:R:S127	R:R:S130	3.26	No	No	0	9	8
71	R:R:N332	R:R:S127	2.98	Yes	No	2	9	9
72	R:R:L128	R:R:Q204	10.65	No	Yes	0	7	7
73	R:R:L129	R:R:S165	3	No	No	0	4	5
74	R:R:H131	R:R:Q204	3.71	Yes	Yes	2	9	7
75	R:R:H131	R:R:L208	5.14	Yes	Yes	2	9	8
76	R:R:F293	R:R:H131	10.18	Yes	Yes	2	9	9
77	R:R:H131	R:R:L328	2.57	Yes	Yes	2	9	9
78	R:R:H131	R:R:N332	6.38	Yes	Yes	2	9	9
79	R:R:H131	R:R:Y336	13.07	Yes	No	0	9	9
80	R:R:C132	R:R:Q204	6.1	No	Yes	0	7	7
81	R:R:C132	R:R:L207	3.17	No	No	0	7	5
82	R:R:L133	R:R:S165	3	No	No	0	5	5
83	R:R:R138	R:R:V134	5.23	No	No	0	9	9
84	R:R:V134	R:R:Y336	3.79	No	No	0	9	9
85	R:R:A135	R:R:L208	3.15	No	Yes	0	8	8
86	R:R:A135	R:R:C211	3.61	No	Yes	0	8	7
87	R:R:A135	R:R:Y212	2.67	No	Yes	0	8	9
88	R:R:L136	R:R:L207	4.15	No	No	4	6	5
89	R:R:C211	R:R:L136	3.17	Yes	No	4	7	6
90	R:R:N137	R:R:Y149	6.98	Yes	Yes	3	9	9
91	R:R:N137	R:R:Y153	10.47	Yes	Yes	3	9	6
92	R:R:R138	R:R:Y212	8.23	No	Yes	0	9	9
93	R:R:T143	R:R:Y139	11.24	No	Yes	0	8	7
94	R:R:H210	R:R:Y139	3.27	No	Yes	0	4	7
95	R:R:C211	R:R:Y139	4.03	Yes	Yes	0	7	7
96	R:R:I215	R:R:Y139	3.63	No	Yes	0	9	7
97	R:R:L140	R:R:R144	4.86	No	No	0	6	7
98	R:R:L140	R:R:Y153	5.86	No	Yes	0	6	6
99	R:R:L141	R:R:Y149	15.24	No	Yes	0	8	9
100	R:R:I142	R:R:I215	5.89	No	No	0	9	9
101	R:R:R218	R:R:T143	2.59	No	No	0	7	8
102	R:R:Y149	R:R:Y153	9.93	Yes	Yes	3	9	6
103	R:R:L152	R:R:Y153	9.38	No	Yes	0	5	6
104	R:R:H157	R:R:Q154	3.71	No	No	0	6	8
105	R:R:L162	R:R:T158	2.95	No	Yes	3	7	7
106	R:R:L168	R:R:L172	4.15	No	No	0	4	5
107	R:R:L172	R:R:L176	2.77	No	No	0	5	5
108	R:R:L176	R:R:P177	3.28	No	No	0	5	8
109	R:R:L176	R:R:Y192	3.52	No	No	0	5	6
110	R:R:P177	R:R:P193	3.9	No	No	0	8	5
111	R:R:H191	R:R:W179	17.98	No	No	0	4	3
112	R:R:A180	R:R:W322	3.89	No	Yes	0	6	4
113	R:R:F309	R:R:V190	15.73	No	No	0	4	3
114	R:R:H191	R:R:P193	10.68	No	No	0	4	5
115	R:R:P193	R:R:Y192	9.74	No	No	0	5	6
116	R:R:L196	R:R:Y192	10.55	No	No	0	6	6
117	R:R:L195	R:R:L305	5.54	No	No	0	5	4
118	R:R:F309	R:R:L195	8.53	No	No	0	4	5
119	R:R:L201	R:R:T297	2.95	No	No	0	5	6
120	R:R:L201	R:R:L300	2.77	No	Yes	0	5	6
121	R:R:L201	R:R:V301	4.47	No	No	0	5	5
122	R:R:L208	R:R:Q204	2.66	Yes	Yes	2	8	7
123	R:R:F293	R:R:Q204	9.37	Yes	Yes	2	9	7
124	R:R:F293	R:R:T205	2.59	Yes	No	0	9	5
125	R:R:Q298	R:R:T205	4.25	Yes	No	0	6	5
126	R:R:C211	R:R:L207	3.17	Yes	No	4	7	5
127	R:R:F293	R:R:L208	7.31	Yes	Yes	2	9	8
128	R:R:V286	R:R:Y212	8.83	No	Yes	0	8	9
129	R:R:L289	R:R:Y212	7.03	No	Yes	0	8	9
130	R:R:C290	R:R:Y212	4.03	No	Yes	0	8	9
131	R:R:R220	R:R:V216	2.62	No	No	0	6	6
132	R:R:R339	R:R:S282	5.27	No	No	0	7	9
133	R:R:L284	R:R:W338	4.56	No	Yes	0	7	5
134	R:R:S285	R:R:W338	7.41	No	Yes	0	9	5
135	R:R:C291	R:R:L287	3.17	No	No	0	6	6
136	R:R:L288	R:R:V292	2.98	No	No	5	6	7
137	R:R:L288	R:R:L335	2.77	No	No	5	6	9
138	R:R:L288	R:R:W338	4.56	No	Yes	0	6	5
139	R:R:L335	R:R:V292	5.96	No	No	5	9	7
140	R:R:F293	R:R:T297	9.08	Yes	No	0	9	6
141	R:R:F293	R:R:L328	4.87	Yes	Yes	2	9	9
142	R:R:A296	R:R:L328	4.73	No	Yes	0	8	9
143	R:R:Q298	R:R:T297	2.83	Yes	No	0	6	6
144	R:R:Q298	R:R:V301	2.87	Yes	No	0	6	5
145	R:R:Q298	R:R:W302	3.29	Yes	No	0	6	5
146	R:R:L324	R:R:P299	3.28	No	No	0	6	9
147	R:R:L300	R:R:S321	4.5	Yes	Yes	1	6	6
148	R:R:L300	R:R:W322	3.42	Yes	Yes	1	6	4
149	R:R:C325	R:R:L300	4.76	No	Yes	0	6	6
150	R:R:V303	R:R:V317	3.21	No	No	0	5	3
151	R:R:S321	R:R:V303	4.85	Yes	No	0	6	5
152	R:R:L311	R:R:P312	4.93	No	No	0	3	3
153	R:R:P314	R:R:V313	3.53	No	No	6	6	5
154	R:R:V313	R:R:V317	3.21	No	No	6	5	3
155	R:R:P314	R:R:V317	3.53	No	No	6	6	3
156	R:R:Q318	R:R:W315	6.57	No	No	0	4	4
157	R:R:S321	R:R:W322	3.71	Yes	Yes	1	6	4
158	R:R:L328	R:R:N332	5.49	Yes	Yes	2	9	9
159	R:R:F343	R:R:T337	9.08	Yes	No	0	9	7
160	R:R:R339	R:R:W338	12	No	Yes	0	7	5
161	R:R:F343	R:R:N340	9.67	Yes	No	0	9	9
162	R:R:E341	R:R:R344	5.82	No	No	0	7	8
163	R:R:E342	R:R:S346	4.31	No	No	0	7	8
164	R:R:M161	R:R:Y153	2.39	No	Yes	0	7	6
165	R:R:E342	R:R:R345	2.33	No	No	0	7	5
166	R:R:G44	R:R:G45	2.11	No	No	0	4	8
167	R:R:G117	R:R:G118	2.11	No	No	0	6	5
168	R:R:C81	R:R:G45	1.96	No	No	0	7	8
169	R:R:A330	R:R:G45	1.95	No	No	0	6	8
170	R:R:A159	R:R:G160	1.95	No	No	0	6	3
171	R:R:P177	R:R:P178	1.95	No	No	0	8	5
172	R:R:A194	R:R:G308	1.95	No	No	0	4	3
173	R:R:A145	R:R:P146	1.87	No	No	0	6	4
174	R:R:G283	R:R:S282	1.86	No	No	0	7	9
175	R:R:G118	R:R:V173	1.84	No	No	0	5	5
176	R:R:P299	R:R:S321	1.78	No	Yes	0	9	6
177	R:R:G40	R:R:I43	1.76	No	No	0	5	5
178	R:R:G44	R:R:L47	1.71	No	No	0	4	2
179	R:R:G117	R:R:L114	1.71	No	No	0	6	4
180	R:R:G171	R:R:L170	1.71	No	No	0	4	4
181	R:R:A198	R:R:S304	1.71	No	No	0	4	7
182	R:R:G50	R:R:N49	1.7	No	Yes	0	4	9
183	R:R:A169	R:R:V126	1.7	No	Yes	0	7	8
184	R:R:A198	R:R:V301	1.7	No	No	0	4	5
185	R:R:A306	R:R:V313	1.7	No	No	0	4	5
186	R:R:A68	R:R:T158	1.68	No	Yes	0	7	7
187	R:R:A169	R:R:T125	1.68	No	No	0	7	7
188	R:R:A145	R:R:T148	1.68	No	No	0	6	6
189	R:R:C74	R:R:I53	1.64	No	No	0	8	8
190	R:R:C74	R:R:I70	1.64	No	No	0	8	9
191	R:R:S304	R:R:S307	1.63	No	No	0	7	4
192	R:R:S310	R:R:V190	1.62	No	No	0	4	3
193	R:R:S222	R:R:V223	1.62	No	No	0	8	4
194	R:R:S227	R:R:V223	1.62	No	No	0	5	4
195	R:R:S227	R:R:V226	1.62	No	No	0	5	6
196	R:R:V216	R:R:V286	1.6	No	No	0	6	8
197	R:R:C290	R:R:L209	1.59	No	No	0	8	4
198	R:R:A82	R:R:L83	1.58	No	No	0	5	5
199	R:R:A198	R:R:L305	1.58	No	No	0	4	4
200	R:R:A330	R:R:L331	1.58	No	No	0	6	6
201	R:R:I53	R:R:S57	1.55	No	No	0	8	4
202	R:R:G214	R:R:R217	1.5	No	No	0	5	4
203	R:R:L323	R:R:V34	1.49	No	No	0	5	6
204	R:R:L281	R:R:V219	1.49	No	No	0	8	8
205	R:R:L281	R:R:V223	1.49	No	No	0	8	4
206	R:R:L294	R:R:T205	1.47	No	No	0	5	5
207	R:R:G214	R:R:Y139	1.45	No	Yes	0	5	7
208	R:R:Q318	R:R:S321	1.44	No	Yes	0	4	6
209	R:R:G316	R:R:W315	1.41	No	No	0	3	4
210	R:R:L122	R:R:L170	1.38	No	No	0	6	4
211	R:R:L129	R:R:L168	1.38	No	No	0	4	4
212	R:R:F59	R:R:S58	1.32	Yes	No	0	8	6
213	R:R:F59	R:R:S349	1.32	Yes	No	0	8	5
214	R:R:R345	R:R:S349	1.32	No	No	0	5	5
215	R:R:R225	R:R:V221	1.31	No	No	0	5	4
216	R:R:F309	R:R:L311	1.22	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N49	6.2125	4	0	9
2	R:R:L55	2.975	4	0	8
3	R:R:F59	3.918	5	0	8
4	R:R:F69	4.988	5	3	9
5	R:R:V80	4.6375	4	1	9
6	R:R:W84	10.115	6	1	6
7	R:R:M85	6.708	5	1	7
8	R:R:V126	5.0825	4	0	8
9	R:R:H131	6.84167	6	2	9
10	R:R:N137	8.0375	4	3	9
11	R:R:Y139	4.724	5	0	7
12	R:R:Y149	8.6625	4	3	9
13	R:R:Y153	7.02667	6	3	6
14	R:R:T158	2.59	4	3	7
15	R:R:Q204	6.498	5	2	7
16	R:R:L208	4.565	4	2	8
17	R:R:C211	3.495	4	4	7
18	R:R:Y212	6.158	5	0	9
19	R:R:F293	7.23333	6	2	9
20	R:R:Q298	3.31	4	0	6
21	R:R:L300	3.8625	4	1	6
22	R:R:S321	3.256	5	1	6
23	R:R:W322	4.95	5	1	4
24	R:R:L328	4.415	4	2	9
25	R:R:N332	7.0775	4	2	9
26	R:R:W338	7.1325	4	0	5
27	R:R:F343	6.454	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C81	R:R:G45	13.7347	1.96	No	No	0	7	8
2	R:R:C81	R:R:M85	15.048	3.24	No	Yes	0	7	7
3	R:R:M85	R:R:W84	23.7777	3.49	Yes	Yes	1	7	6
4	R:R:W322	R:R:W84	80.6313	10.31	Yes	Yes	1	4	6
5	R:R:L300	R:R:W322	80.2505	3.42	Yes	Yes	1	6	4
6	R:R:L201	R:R:L300	91.2372	2.77	No	Yes	0	5	6
7	R:R:L201	R:R:T297	91.8938	2.95	No	No	0	5	6
8	R:R:F293	R:R:T297	100	9.08	Yes	No	0	9	6
9	R:R:F293	R:R:H131	46.2477	10.18	Yes	Yes	2	9	9
10	R:R:H131	R:R:N332	51.5837	6.38	Yes	Yes	2	9	9
11	R:R:D77	R:R:N332	88.6547	13.46	No	Yes	2	9	9
12	R:R:D77	R:R:N49	88.009	5.39	No	Yes	0	9	9
13	R:R:F293	R:R:L328	44.995	4.87	Yes	Yes	2	9	9
14	R:R:L328	R:R:N332	43.759	5.49	Yes	Yes	2	9	9
15	R:R:N49	R:R:P333	81.9391	8.15	Yes	No	0	9	9
16	R:R:P333	R:R:V52	78.8379	3.53	No	No	0	9	9
17	R:R:C74	R:R:V52	77.2266	3.42	No	No	0	8	9
18	R:R:C74	R:R:I70	72.4258	1.64	No	No	0	8	9
19	R:R:I70	R:R:N67	38.1691	2.83	No	No	0	9	9
20	R:R:F343	R:R:N67	30.99	7.25	Yes	No	0	9	9
21	R:R:F343	R:R:L55	47.8369	3.65	Yes	Yes	0	9	8
22	R:R:I70	R:R:T337	32.6344	3.04	No	No	0	9	7
23	R:R:F343	R:R:T337	30.8851	9.08	Yes	No	0	9	7
24	R:R:F59	R:R:L55	36.9109	2.44	Yes	Yes	0	8	8
25	R:R:F59	R:R:S346	14.9597	11.89	Yes	No	0	8	8
26	R:R:E342	R:R:S346	11.2515	4.31	No	No	0	7	8
27	R:R:L120	R:R:W84	62.3607	29.61	No	Yes	0	5	6
28	R:R:L120	R:R:L83	59.7782	2.77	No	No	0	5	5
29	R:R:L119	R:R:L83	57.9572	4.15	No	No	0	5	5
30	R:R:L119	R:R:R113	57.0522	2.43	No	No	0	5	8
31	R:R:R113	R:R:V173	55.2091	2.62	No	No	0	8	5
32	R:R:L122	R:R:V173	51.3906	2.98	No	No	0	6	5
33	R:R:L122	R:R:V126	48.4108	2.98	No	Yes	0	6	8
34	R:R:V126	R:R:W166	44.2832	12.26	Yes	No	0	8	8
35	R:R:N72	R:R:W166	43.2182	6.78	No	No	0	9	8
36	R:R:L162	R:R:N72	42.1311	6.87	No	No	0	7	9
37	R:R:F69	R:R:L162	34.7809	2.44	Yes	No	3	9	7
38	R:R:F69	R:R:L133	21.3222	8.53	Yes	No	0	9	5
39	R:R:L129	R:R:S165	18.8114	3	No	No	0	4	5
40	R:R:L133	R:R:S165	20.053	3	No	No	0	5	5
41	R:R:F293	R:R:L208	15.8868	7.31	Yes	Yes	2	9	8
42	R:R:A135	R:R:L208	21.2063	3.15	No	Yes	0	8	8
43	R:R:A135	R:R:C211	11.9965	3.61	No	Yes	0	8	7
44	R:R:L129	R:R:L168	17.5091	1.38	No	No	0	4	4
45	R:R:L168	R:R:L172	16.2068	4.15	No	No	0	4	5
46	R:R:L172	R:R:L176	14.8935	2.77	No	No	0	5	5
47	R:R:F309	R:R:L195	14.8935	8.53	No	No	0	4	5
48	R:R:L195	R:R:L305	17.8402	5.54	No	No	0	5	4
49	R:R:A198	R:R:L305	20.7759	1.58	No	No	0	4	4
50	R:R:A198	R:R:V301	29.5166	1.7	No	No	0	4	5
51	R:R:L201	R:R:V301	17.1173	4.47	No	No	0	5	5
52	R:R:F293	R:R:T205	12.8849	2.59	Yes	No	0	9	5
53	R:R:Q298	R:R:T297	12.5152	2.83	Yes	No	0	6	6
54	R:R:Q298	R:R:T205	12.5869	4.25	Yes	No	0	6	5
55	R:R:Q298	R:R:V301	19.7881	2.87	Yes	No	0	6	5
56	R:R:L300	R:R:S321	10.1313	4.5	Yes	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7WZ4_nogp

PDB Summary
PDB	7WZ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.43
Number of Linked Nodes	200
Number of Links	216
Number of Hubs	27
Number of Links mediated by Hubs	100
Number of Communities	6
Number of Nodes involved in Communities	32
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	29991
Length Of Smallest Path	3
Average Path Length	17.4909
Length of Longest Path	43
Minimum Path Strength	1.32
Average Path Strength	5.6392
Maximum Path Strength	19.96
Minimum Path Correlation	0.7
Average Path Correlation	0.909689
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	33.9522
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.4658
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • nervous system process • biological regulation • action potential • transmission of nerve impulse • cell communication • neuronal action potential • cellular process • regulation of biological quality • regulation of membrane potential • behavior • locomotory behavior • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • phototransduction • detection of light stimulus • detection of external stimulus • regulation of biological process • regulation of cellular process • signaling • response to external stimulus • detection of abiotic stimulus • detection of stimulus • signal transduction • G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • learning • learning or memory • motor learning • cognition • neuromuscular process • neuromuscular process controlling balance • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • intracellular organelle • nucleus • intracellular membrane-bounded organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • intracellular organelle • nucleus • intracellular membrane-bounded organelle • ciliary membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZN0
Sequence	>7WZ4_nogp_Chain_R V S L L Y S G L A I G G T L A N G M V I Y L V S S F R K L Q T T S N A F I V N G C A A D L S V C A L W M P Q E R L L R G G L L G L G L T V S L L S H C L V A L N R Y L L I T R A P A T Y Q A L Y Q R R H T A G M L A L S W A L A L G L V L L L P P W A V H Y P A L L A A A A L L A Q T A L L L H C Y L G I V R R V R V S V K R V S R L S G L S V L L L C C V F L L A T Q P L V W V S L A S G F S L P V P W G V Q A A S W L L C C A L S A L N P L L Y T W R N E E F R R S V R S V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WZ4	A	Orphan	Orphan	GPR88	Homo sapiens	-	-	Gi1/β1/γ2	3	2022-10-26	10.1038/s41467-022-30081-5
	7WZ4 (No Gprot)	A	Orphan	Orphan	GPR88	Homo sapiens	-	-		3	2022-10-26	10.1038/s41467-022-30081-5
	7EJX	A	Orphan	Orphan	GPR88	Homo sapiens	-	(1R;2R)-2-PCCA	Gi1/β1/γ2	2.4	2022-04-13	10.1038/s41467-022-30081-5
	7EJX (No Gprot)	A	Orphan	Orphan	GPR88	Homo sapiens	-	(1R;2R)-2-PCCA		2.4	2022-04-13	10.1038/s41467-022-30081-5

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WZ4_nogp.zip

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