Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N49 6.2125409
2R:R:L55 2.975408
3R:R:F59 3.918508
4R:R:F69 4.988539
5R:R:V80 4.6375419
6R:R:W84 10.115616
7R:R:M85 6.708517
8R:R:V126 5.0825408
9R:R:H131 6.84167629
10R:R:N137 8.0375439
11R:R:Y139 4.724507
12R:R:Y149 8.6625439
13R:R:Y153 7.02667636
14R:R:T158 2.59437
15R:R:Q204 6.498527
16R:R:L208 4.565428
17R:R:C211 3.495447
18R:R:Y212 6.158509
19R:R:F293 7.23333629
20R:R:Q298 3.31406
21R:R:L300 3.8625416
22R:R:S321 3.256516
23R:R:W322 4.95514
24R:R:L328 4.415429
25R:R:N332 7.0775429
26R:R:W338 7.1325405
27R:R:F343 6.454509
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:C81 R:R:G45 13.73471.96NoNo078
2R:R:C81 R:R:M85 15.0483.24NoYes077
3R:R:M85 R:R:W84 23.77773.49YesYes176
4R:R:W322 R:R:W84 80.631310.31YesYes146
5R:R:L300 R:R:W322 80.25053.42YesYes164
6R:R:L201 R:R:L300 91.23722.77NoYes056
7R:R:L201 R:R:T297 91.89382.95NoNo056
8R:R:F293 R:R:T297 1009.08YesNo096
9R:R:F293 R:R:H131 46.247710.18YesYes299
10R:R:H131 R:R:N332 51.58376.38YesYes299
11R:R:D77 R:R:N332 88.654713.46NoYes299
12R:R:D77 R:R:N49 88.0095.39NoYes099
13R:R:F293 R:R:L328 44.9954.87YesYes299
14R:R:L328 R:R:N332 43.7595.49YesYes299
15R:R:N49 R:R:P333 81.93918.15YesNo099
16R:R:P333 R:R:V52 78.83793.53NoNo099
17R:R:C74 R:R:V52 77.22663.42NoNo089
18R:R:C74 R:R:I70 72.42581.64NoNo089
19R:R:I70 R:R:N67 38.16912.83NoNo099
20R:R:F343 R:R:N67 30.997.25YesNo099
21R:R:F343 R:R:L55 47.83693.65YesYes098
22R:R:I70 R:R:T337 32.63443.04NoNo097
23R:R:F343 R:R:T337 30.88519.08YesNo097
24R:R:F59 R:R:L55 36.91092.44YesYes088
25R:R:F59 R:R:S346 14.959711.89YesNo088
26R:R:E342 R:R:S346 11.25154.31NoNo078
27R:R:L120 R:R:W84 62.360729.61NoYes056
28R:R:L120 R:R:L83 59.77822.77NoNo055
29R:R:L119 R:R:L83 57.95724.15NoNo055
30R:R:L119 R:R:R113 57.05222.43NoNo058
31R:R:R113 R:R:V173 55.20912.62NoNo085
32R:R:L122 R:R:V173 51.39062.98NoNo065
33R:R:L122 R:R:V126 48.41082.98NoYes068
34R:R:V126 R:R:W166 44.283212.26YesNo088
35R:R:N72 R:R:W166 43.21826.78NoNo098
36R:R:L162 R:R:N72 42.13116.87NoNo079
37R:R:F69 R:R:L162 34.78092.44YesNo397
38R:R:F69 R:R:L133 21.32228.53YesNo095
39R:R:L129 R:R:S165 18.81143NoNo045
40R:R:L133 R:R:S165 20.0533NoNo055
41R:R:F293 R:R:L208 15.88687.31YesYes298
42R:R:A135 R:R:L208 21.20633.15NoYes088
43R:R:A135 R:R:C211 11.99653.61NoYes087
44R:R:L129 R:R:L168 17.50911.38NoNo044
45R:R:L168 R:R:L172 16.20684.15NoNo045
46R:R:L172 R:R:L176 14.89352.77NoNo055
47R:R:F309 R:R:L195 14.89358.53NoNo045
48R:R:L195 R:R:L305 17.84025.54NoNo054
49R:R:A198 R:R:L305 20.77591.58NoNo044
50R:R:A198 R:R:V301 29.51661.7NoNo045
51R:R:L201 R:R:V301 17.11734.47NoNo055
52R:R:F293 R:R:T205 12.88492.59YesNo095
53R:R:Q298 R:R:T297 12.51522.83YesNo066
54R:R:Q298 R:R:T205 12.58694.25YesNo065
55R:R:Q298 R:R:V301 19.78812.87YesNo065
56R:R:L300 R:R:S321 10.13134.5YesYes166
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WZ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.43
Number of Linked Nodes 200
Number of Links 216
Number of Hubs 27
Number of Links mediated by Hubs 100
Number of Communities 6
Number of Nodes involved in Communities 32
Number of Links involved in Communities 43
Path Summary
Number Of Nodes in MetaPath 57
Number Of Links MetaPath 56
Number of Shortest Paths 29991
Length Of Smallest Path 3
Average Path Length 17.4909
Length of Longest Path 43
Minimum Path Strength 1.32
Average Path Strength 5.6392
Maximum Path Strength 19.96
Minimum Path Correlation 0.7
Average Path Correlation 0.909681
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 33.9522
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.4658
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9GZN0
Sequence
>7WZ4_nogp_Chain_R
VSLLYSGLA IGGTLANGM VIYLVSSFR KLQTTSNAF IVNGCAADL 
SVCALWMPQ ERLLRGGLL GLGLTVSLL SHCLVALNR YLLITRAPA 
TYQALYQRR HTAGMLALS WALALGLVL LLPPWAVHY PALLAAAAL 
LAQTALLLH CYLGIVRRV RVSVKRVSR LSGLSVLLL CCVFLLATQ 
PLVWVSLAS GFSLPVPWG VQAASWLLC CALSALNPL LYTWRNEEF 
RRSVRSVL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EJXAOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCAGi1/β1/γ22.42022-04-13doi.org/10.1038/s41467-022-30081-5
7EJX (No Gprot) AOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCA2.42022-04-13doi.org/10.1038/s41467-022-30081-5
7WZ4AOrphanOrphanGPR88Homo sapiens--Gi1/β1/γ232022-10-26doi.org/10.1038/s41467-022-30081-5
7WZ4 (No Gprot) AOrphanOrphanGPR88Homo sapiens--32022-10-26doi.org/10.1038/s41467-022-30081-5




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Download 7WZ4_nogp.zip



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