Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.095115
2A:A:L38 3.19408
3A:A:K46 3.992509
4A:A:F191 8.16405
5A:A:F196 6.2985117
6A:A:K197 9.3375416
7A:A:F199 7.848515
8A:A:Q204 5.6975419
9A:A:S206 4.6875418
10A:A:K210 5.18143719
11A:A:W211 6.235419
12A:A:H213 6.61418
13A:A:F215 5.342519
14A:A:F223 5.994109
15A:A:S228 7.1825459
16A:A:Y230 5.86857758
17A:A:W258 6.08667615
18A:A:F259 5.26519
19A:A:N269 5.3775409
20A:A:K277 5.3575459
21A:A:I278 4.316556
22A:A:S281 4.354557
23A:A:Y287 3.584507
24A:A:Y302 11.2025406
25A:A:R313 4.41404
26A:A:Y320 4.8425407
27A:A:T321 6.7954105
28A:A:F323 4.3275404
29A:A:F336 4.9325118
30A:A:L348 3.8275409
31A:A:L353 2.7425407
32B:B:L30 3.63405
33B:B:T34 2.9954125
34B:B:I37 4.7585122
35B:B:V40 3.1125403
36B:B:M45 4.075474
37B:B:H54 9.46667629
38B:B:Y59 8.256518
39B:B:M61 4.2075426
40B:B:W63 5.65667627
41B:B:D76 5.55429
42B:B:I81 3.8265197
43B:B:W82 10.0083629
44B:B:N88 5.56407
45B:B:K89 5.50143729
46B:B:H91 4.595405
47B:B:I93 5.405407
48B:B:L95 5.15754138
49B:B:W99 6.765819
50B:B:Y105 4.251676196
51B:B:N110 6.194144
52B:B:Y111 6.4054144
53B:B:C114 3.81754138
54B:B:I123 3.13406
55B:B:Y124 5.432506
56B:B:E130 3.585403
57B:B:H142 6.05719
58B:B:Y145 4.39143718
59B:B:F151 3.58667619
60B:B:T159 6.0875419
61B:B:D163 6.72419
62B:B:W169 7.20857718
63B:B:I171 3.41416
64B:B:T173 3.675405
65B:B:Q176 7.5414
66B:B:F180 7.7725437
67B:B:H183 8.926539
68B:B:D186 4.176519
69B:B:C204 5.9125417
70B:B:D205 6.3325439
71B:B:K209 8.386536
72B:B:L210 4.56505
73B:B:W211 8.652538
74B:B:R219 6.91254215
75B:B:Q220 6.39447
76B:B:F222 5.9448
77B:B:H225 8.65667649
78B:B:D228 7.2525419
79B:B:I232 4.402508
80B:B:F235 5.4085156
81B:B:P236 5.66754157
82B:B:D246 7.55419
83B:B:T249 5.2125446
84B:B:R251 10.6575448
85B:B:F253 6.8625446
86B:B:D258 8.84447
87B:B:Y264 5.59167605
88B:B:I273 5.9825406
89B:B:L285 3.5725406
90B:B:Y289 7.39167667
91B:B:N295 6.886566
92B:B:W297 5.715468
93B:B:L300 5.074126
94B:B:R304 6.015465
95B:B:V307 3.1463
96B:B:H311 8.358579
97B:B:M325 5.155405
98B:B:W332 10.2029719
99B:B:D333 6.372579
100B:B:L336 4.275407
101B:B:K337 7.46476
102B:B:W339 7.29333679
103G:G:D48 6.52409
104G:G:P60 5.70754189
105G:G:F61 4.754297188
106R:R:N49 6.2125409
107R:R:L55 2.975408
108R:R:F59 3.918508
109R:R:F69 5.6254169
110R:R:W84 11.648586
111R:R:M85 6.708587
112R:R:V126 5.0825408
113R:R:H131 7.696599
114R:R:N137 8.03754169
115R:R:R138 6.015409
116R:R:Y139 4.724507
117R:R:Y153 7.026676166
118R:R:T158 2.59407
119R:R:Q204 7.4575497
120R:R:C211 3.4954227
121R:R:Y212 7.03409
122R:R:F293 8.162599
123R:R:Q298 3.31406
124R:R:L300 3.8625486
125R:R:S321 3.256586
126R:R:W322 4.95584
127R:R:N332 7.0775499
128R:R:W338 7.1325405
129R:R:F343 7.4125409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M325 G:G:P60 12.63176.71YesYes059
2B:B:M325 G:G:P49 39.99196.71YesNo057
3G:G:D48 G:G:P49 41.26933.22YesNo097
4B:B:S279 G:G:D48 42.96548.83NoYes099
5B:B:L284 B:B:S279 43.38824.5NoNo059
6B:B:L284 B:B:V296 43.81045.96NoNo055
7B:B:L286 B:B:V296 26.30172.98NoNo075
8B:B:C294 B:B:L286 26.10153.17NoNo057
9B:B:C294 B:B:L318 26.70293.17NoNo056
10B:B:L318 B:B:T329 28.0082.95NoNo068
11B:B:H311 B:B:T329 35.05745.48YesNo098
12B:B:D333 B:B:H311 43.5447.56YesYes799
13B:B:D333 B:B:N313 85.7354.04YesNo097
14B:B:N313 B:B:W332 85.69556.78NoYes079
15B:B:W332 B:B:Y59 69.82397.72YesYes198
16B:B:Q75 B:B:Y59 69.903115.78NoYes198
17B:B:Q75 B:B:W99 70.16514.38NoYes199
18B:B:L117 B:B:W99 63.26984.56NoYes099
19B:B:L117 B:B:M101 63.02032.83NoNo099
20B:B:M101 B:B:Y145 62.52254.79NoYes098
21B:B:S147 B:B:Y145 63.03553.82NoYes098
22B:B:S147 B:B:S160 62.69093.26NoNo096
23B:B:S160 B:B:V187 62.00754.85NoNo069
24B:B:S201 B:B:V187 33.85023.23NoNo399
25B:B:S201 B:B:W211 33.60296.18NoYes398
26B:B:F199 B:B:W211 13.093213.03NoYes398
27B:B:F199 B:B:L190 12.73194.87NoNo095
28B:B:G306 B:B:V296 19.88421.84NoNo045
29B:B:G306 B:B:V307 19.85911.84NoYes043
30B:B:N295 B:B:V307 20.14214.43YesYes663
31B:B:N295 B:B:Y289 20.170310.47YesYes667
32B:B:C271 B:B:Y289 42.28274.03NoYes057
33B:B:C271 B:B:D290 42.87396.22NoNo056
34B:B:D290 B:B:R314 43.776121.44NoNo068
35B:B:R314 B:B:W332 25.717218.99NoYes189
36B:B:G162 B:B:Y145 25.0544.35NoYes198
37B:B:G162 B:B:S161 28.23723.71NoNo199
38B:B:H142 B:B:S161 24.965512.55YesNo199
39B:B:H142 B:B:T159 11.91836.85YesYes199
40B:B:C121 B:B:T159 11.62343.38NoYes089
41B:B:C121 B:B:C149 11.50651.82NoNo088
42B:B:C149 B:B:T102 11.04076.76NoNo088
43B:B:G115 B:B:T102 10.58931.82NoNo098
44B:B:C114 B:B:G115 10.17453.92YesNo089
45A:A:W258 B:B:R314 18.36193YesNo158
46A:A:N256 A:A:W258 34.17993.39NoYes185
47A:A:I212 A:A:N256 15.24122.83NoNo188
48A:A:I212 A:A:R208 15.0526.26NoNo089
49A:A:L249 A:A:R208 15.02843.64NoNo099
50A:A:F223 A:A:L249 15.00874.87YesNo099
51A:A:F223 A:A:L266 56.00943.65YesNo1099
52A:A:L266 A:A:T321 56.25934.42NoYes1095
53A:A:L268 A:A:T321 50.65892.95NoYes085
54A:A:L268 A:A:V225 47.77632.98NoNo087
55A:A:F307 A:A:V225 46.77967.87NoNo087
56A:A:F307 A:A:M247 46.61144.98NoNo086
57A:A:M247 A:A:Y287 46.12543.59NoYes067
58A:A:M243 A:A:Y287 44.363.59NoYes087
59A:A:M243 A:A:Y230 43.43235.99NoYes088
60A:A:K277 A:A:Y230 40.9539.55YesYes598
61A:A:K277 A:A:S228 40.92434.59YesYes599
62A:A:K270 A:A:S228 40.60910.71NoYes099
63A:A:K270 A:A:N269 40.45412.8NoYes099
64A:A:C224 A:A:N269 38.33963.15NoYes079
65A:A:C224 A:A:K46 19.56013.23NoYes079
66A:A:K46 A:A:L38 18.21534.23YesYes098
67A:A:I222 A:A:L38 35.12542.85NoYes078
68A:A:I222 A:A:L36 20.05067.14NoNo077
69A:A:F259 A:A:N256 18.75524.83YesNo198
70A:A:F259 A:A:I253 16.03315.02YesNo098
71A:A:I253 A:A:L39 16.00824.28NoNo089
72A:A:F223 A:A:L39 44.52283.65YesNo099
73A:A:C224 A:A:I49 18.64133.27NoNo077
74A:A:I49 A:A:L38 17.96812.85NoYes078
75A:A:L36 A:A:V34 19.36632.98NoYes075
76A:A:F215 A:A:L37 31.28388.53YesNo099
77A:A:L37 A:A:L39 30.99315.54NoNo099
78A:A:F215 A:A:W211 32.87154.01YesYes199
79A:A:Q204 A:A:W211 14.65319.86YesYes199
80A:A:S206 A:A:W211 18.32474.94YesYes189
81A:A:I222 A:A:I265 19.26692.94NoNo078
82A:A:A338 A:A:I265 18.73343.25NoNo068
83A:A:A338 A:A:Y320 18.20145.34NoYes067
84A:A:D341 A:A:Y320 15.54425.75NoYes087
85B:B:D312 B:B:D333 1006.65NoYes059
86B:B:D312 R:R:K61 99.93878.3NoNo057
87R:R:K61 R:R:L62 99.88955.64NoNo079
88R:R:E342 R:R:L62 99.8414.58NoNo079
89R:R:E342 R:R:S346 99.37194.31NoNo078
90R:R:F59 R:R:S346 99.384511.89YesNo088
91R:R:F59 R:R:L55 99.86052.44YesYes088
92R:R:F343 R:R:L55 99.94133.65YesYes098
93R:R:F343 R:R:N67 50.28927.25YesNo099
94R:R:I70 R:R:N67 50.04512.83NoNo099
95R:R:C74 R:R:I70 99.47571.64NoNo089
96R:R:C74 R:R:V52 98.77973.42NoNo089
97R:R:P333 R:R:V52 98.55693.53NoNo099
98R:R:N49 R:R:P333 98.16118.15YesNo099
99R:R:D77 R:R:N49 97.38795.39NoYes099
100R:R:D77 R:R:N332 96.216913.46NoYes999
101R:R:H131 R:R:N332 70.19466.38YesYes999
102R:R:A135 R:R:L208 10.53753.15NoNo088
103R:R:A135 R:R:C211 10.26223.61NoYes087
104R:R:C211 R:R:Y139 10.01354.03YesYes077
105R:R:I142 R:R:I215 17.26425.89NoNo099
106A:A:L348 R:R:I142 16.68612.85YesNo099
107A:A:I344 A:A:L348 13.84942.85NoYes069
108A:A:I344 R:R:S222 13.8444.64NoNo068
109R:R:S222 R:R:V223 13.85511.62NoNo084
110R:R:S227 R:R:V223 13.95271.62NoNo054
111R:R:S227 R:R:V226 14.1541.62NoNo056
112R:R:F343 R:R:T337 49.73779.08YesNo097
113R:R:I70 R:R:T337 49.67673.04NoNo097
114R:R:H131 R:R:Y336 38.145313.07YesNo099
115R:R:V134 R:R:Y336 37.86973.79NoNo099
116R:R:R138 R:R:V134 37.61495.23YesNo099
117A:A:L353 R:R:R138 13.3913.64YesYes079
118A:A:D341 R:R:V226 14.48195.84NoNo086
119A:A:C351 R:R:R138 32.12086.96NoYes049
120A:A:C351 R:R:L141 31.74994.76NoNo048
121B:B:H183 B:B:V187 27.81658.3YesNo399
122B:B:H183 B:B:K209 25.335214.41YesYes396
123B:B:C218 B:B:K209 19.04236.47NoYes356
124B:B:C218 G:G:Q18 38.16386.1NoNo059
125G:G:M21 G:G:Q18 37.35034.08NoNo019
126B:B:M217 G:G:M21 36.56744.33NoNo031
127B:B:M217 B:B:R219 34.98876.2NoYes2135
128B:B:L210 B:B:R219 31.07264.86YesYes055
129B:B:L210 B:B:Q220 10.38016.65YesYes057
130B:B:C218 B:B:W211 19.89655.22NoYes358
131B:B:W297 B:B:Y264 17.93766.75YesYes085
132B:B:I43 B:B:M45 10.66082.92NoYes034
133B:B:M45 B:B:W339 12.40413.49YesYes749
134B:B:L70 B:B:W82 13.70565.69NoYes259
135B:B:L70 B:B:W63 14.12839.11NoYes257
136B:B:T321 B:B:W63 23.93499.7NoYes277
137B:B:H142 B:B:W169 10.85237.41YesYes198
138B:B:D323 B:B:T321 24.35032.89NoNo277
139B:B:D323 B:B:M325 25.24624.16NoYes075
140B:B:L210 B:B:V200 18.35422.98YesNo056
141B:B:I232 B:B:V200 13.59676.14YesNo086
142B:B:I232 B:B:T243 10.40983.04YesNo088
143R:R:F293 R:R:H131 27.904710.18YesYes999
144R:R:F293 R:R:T297 56.92959.08YesNo096
145R:R:L201 R:R:T297 45.16682.95NoNo056
146R:R:L201 R:R:L300 36.49152.77NoYes056
147R:R:L300 R:R:W322 26.82853.42YesYes864
148R:R:W322 R:R:W84 22.45710.31YesYes846
149R:R:M85 R:R:W84 13.52493.49YesYes876
150R:R:L328 R:R:N332 26.45115.49NoYes099
151R:R:F293 R:R:L328 25.92924.87YesNo099
152R:R:L141 R:R:Y149 31.378415.24NoNo089
153R:R:N137 R:R:Y149 14.91446.98YesNo1699
154R:R:F69 R:R:N137 14.14787.25YesYes1699
155R:R:F69 R:R:T158 15.03122.59YesYes097
156R:R:Y149 R:R:Y153 16.09189.93NoYes1696
157R:R:F69 R:R:Y153 14.17554.13YesYes1696
158R:R:F69 R:R:L133 12.67028.53YesNo095
159R:R:L162 R:R:T158 12.67022.95NoYes077
160R:R:L162 R:R:N72 11.88216.87NoNo079
161R:R:N72 R:R:W166 11.09356.78NoNo098
162R:R:V126 R:R:W166 10.304512.26YesNo088
163R:R:L133 R:R:S165 11.88213NoNo055
164R:R:L129 R:R:S165 11.09353NoNo045
165R:R:L129 R:R:L168 10.30451.38NoNo044
166R:R:A198 R:R:V301 14.93281.7NoNo045
167R:R:A198 R:R:L305 10.45831.58NoNo044
168R:R:Q298 R:R:T297 11.14512.83YesNo066
169A:A:Q204 B:B:Y145 13.3884.51YesYes198
170A:A:S206 B:B:Y145 13.13495.09YesYes188
171A:A:W258 B:B:W332 16.09034.69YesYes159
172B:B:W297 B:B:Y289 17.69777.72YesYes687
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WZ4
Class A
SubFamily Orphan
Type Orphan
SubType GPR88
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2022-10-26
D.O.I. 10.1038/s41467-022-30081-5
Net Summary
Imin 2.8
Number of Linked Nodes 776
Number of Links 904
Number of Hubs 129
Number of Links mediated by Hubs 494
Number of Communities 23
Number of Nodes involved in Communities 172
Number of Links involved in Communities 235
Path Summary
Number Of Nodes in MetaPath 173
Number Of Links MetaPath 172
Number of Shortest Paths 866427
Length Of Smallest Path 3
Average Path Length 32.4833
Length of Longest Path 62
Minimum Path Strength 1.12
Average Path Strength 5.83064
Maximum Path Strength 21.55
Minimum Path Correlation 0.7
Average Path Correlation 0.976889
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 42.0254
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.7984
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • system process   • nervous system process   • biological regulation   • action potential   • transmission of nerve impulse   • cell communication   • neuronal action potential   • cellular process   • regulation of biological quality   • regulation of membrane potential   • behavior   • locomotory behavior   • cellular response to stimulus   • response to light stimulus   • response to stimulus   • cellular response to light stimulus   • response to radiation   • response to abiotic stimulus   • cellular response to radiation   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • phototransduction   • detection of light stimulus   • detection of external stimulus   • regulation of biological process   • regulation of cellular process   • signaling   • response to external stimulus   • detection of abiotic stimulus   • detection of stimulus   • signal transduction   • G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • learning   • learning or memory   • motor learning   • cognition   • neuromuscular process   • neuromuscular process controlling balance   • membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • intracellular organelle   • nucleus   • intracellular membrane-bounded organelle
Gene OntologyCellular Component• membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • cell periphery   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • intracellular organelle   • nucleus   • intracellular membrane-bounded organelle   • ciliary membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WZ4_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WZ4_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WZ4_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9GZN0
Sequence
>7WZ4_Chain_R
VSLLYSGLA IGGTLANGM VIYLVSSFR KLQTTSNAF IVNGCAADL 
SVCALWMPQ ERLLRGGLL GLGLTVSLL SHCLVALNR YLLITRAPA 
TYQALYQRR HTAGMLALS WALALGLVL LLPPWAVHY PALLAAAAL 
LAQTALLLH CYLGIVRRV RVSVKRVSR LSGLSVLLL CCVFLLATQ 
PLVWVSLAS GFSLPVPWG VQAASWLLC CALSALNPL LYTWRNEEF 
RRSVRSVL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WZ4AOrphanOrphanGPR88Homo sapiens--Gi1/β1/γ232022-10-2610.1038/s41467-022-30081-5
7WZ4 (No Gprot) AOrphanOrphanGPR88Homo sapiens--32022-10-2610.1038/s41467-022-30081-5
7EJXAOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCAGi1/β1/γ22.42022-04-1310.1038/s41467-022-30081-5
7EJX (No Gprot) AOrphanOrphanGPR88Homo sapiens-(1R;2R)-2-PCCA2.42022-04-1310.1038/s41467-022-30081-5




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