Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N49 5.875409
2R:R:L55 2.975408
3R:R:F59 3.918508
4R:R:F69 5.6254129
5R:R:D77 7.655499
6R:R:L83 3.64254175
7R:R:W84 12.175436
8R:R:M85 4.054537
9R:R:R116 7.20754175
10R:R:V126 5.0825408
11R:R:H131 7.696599
12R:R:N137 8.03754129
13R:R:R138 6.015409
14R:R:Y139 4.724507
15R:R:Y153 7.026676126
16R:R:T158 2.59407
17R:R:Q204 7.4575497
18R:R:C211 3.4954187
19R:R:Y212 7.03409
20R:R:F293 8.162599
21R:R:Q298 3.31406
22R:R:V313 2.5154195
23R:R:S321 4.7536
24R:R:W322 7.27833634
25R:R:N332 7.415499
26R:R:W338 7.1325405
27R:R:F343 7.4125409
28A:A:V34 5.095115
29A:A:L38 3.19408
30A:A:K46 3.992509
31A:A:F191 8.16405
32A:A:F196 6.2985117
33A:A:K197 9.3375416
34A:A:F199 7.848515
35A:A:Q204 5.6975419
36A:A:S206 4.6875418
37A:A:K210 5.18143719
38A:A:W211 6.235419
39A:A:H213 6.61418
40A:A:F215 5.342519
41A:A:F223 5.994109
42A:A:S228 7.1825469
43A:A:Y230 5.86857768
44A:A:W258 6.08667615
45A:A:F259 5.26519
46A:A:N269 5.3775409
47A:A:K277 5.3575469
48A:A:I278 4.316566
49A:A:S281 5.578567
50A:A:Y287 4.2045207
51A:A:Y302 10.36254206
52A:A:R313 4.41404
53A:A:Y320 4.8425407
54A:A:T321 6.7954105
55A:A:F323 4.3275404
56A:A:F336 4.9325118
57A:A:L348 3.6075409
58A:A:L353 2.7425407
59B:B:L30 3.63405
60B:B:T34 2.9954135
61B:B:I37 4.7585132
62B:B:V40 3.1125403
63B:B:M45 4.075484
64B:B:H54 9.46667629
65B:B:Y59 8.256518
66B:B:M61 4.2075426
67B:B:W63 5.65667627
68B:B:D76 5.55429
69B:B:I81 3.8265237
70B:B:W82 10.0083629
71B:B:N88 5.56407
72B:B:K89 5.50143729
73B:B:H91 4.595405
74B:B:I93 5.405407
75B:B:L95 5.15754148
76B:B:W99 6.765819
77B:B:Y105 4.251676236
78B:B:N110 6.194154
79B:B:Y111 6.4054154
80B:B:C114 3.81754148
81B:B:I123 3.13406
82B:B:Y124 5.432506
83B:B:E130 3.585403
84B:B:H142 6.05719
85B:B:Y145 4.39143718
86B:B:F151 3.58667619
87B:B:T159 6.0875419
88B:B:D163 6.72419
89B:B:W169 7.20857718
90B:B:I171 3.41416
91B:B:T173 3.675405
92B:B:Q176 7.5414
93B:B:F180 7.7725447
94B:B:H183 8.926549
95B:B:D186 4.176519
96B:B:C204 5.9125417
97B:B:D205 6.3325449
98B:B:K209 8.386546
99B:B:L210 4.56505
100B:B:W211 8.652548
101B:B:R219 6.91254255
102B:B:Q220 6.39457
103B:B:F222 5.9458
104B:B:H225 8.65667659
105B:B:D228 7.2525419
106B:B:I232 4.402508
107B:B:F235 5.4085166
108B:B:P236 5.66754167
109B:B:D246 7.55419
110B:B:T249 5.2125456
111B:B:R251 10.6575458
112B:B:F253 6.8625456
113B:B:D258 8.84457
114B:B:Y264 5.59167605
115B:B:I273 5.9825406
116B:B:L285 3.5725406
117B:B:Y289 7.39167677
118B:B:N295 6.886576
119B:B:W297 5.715478
120B:B:L300 5.074136
121B:B:R304 6.015475
122B:B:V307 3.1473
123B:B:H311 8.358589
124B:B:M325 5.155405
125B:B:W332 10.2029719
126B:B:D333 6.3025489
127B:B:L336 4.275407
128B:B:K337 7.46486
129B:B:W339 7.29333689
130G:G:D48 6.52409
131G:G:P60 5.70754229
132G:G:F61 4.754297228
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D77 R:R:N49 95.96834.04YesYes099
2R:R:D77 R:R:S329 20.62832.94YesNo099
3R:R:S329 R:R:V80 20.09594.85NoNo099
4R:R:L124 R:R:V80 19.02957.45NoNo069
5R:R:L124 R:R:W322 18.49543.42NoYes064
6R:R:W322 R:R:W84 13.123714.99YesYes346
7R:R:N49 R:R:P333 96.978.15YesNo099
8R:R:F343 R:R:L55 99.42193.65YesYes098
9R:R:F343 R:R:N67 50.02297.25YesNo099
10R:R:I70 R:R:N67 49.65722.83NoNo099
11R:R:C74 R:R:I70 98.64061.64NoNo089
12R:R:C74 R:R:V52 97.76413.42NoNo089
13R:R:P333 R:R:V52 97.48113.53NoNo099
14R:R:F343 R:R:T337 49.38159.08YesNo097
15R:R:I70 R:R:T337 49.29013.04NoNo097
16R:R:F59 R:R:L55 99.44492.44YesYes088
17R:R:F59 R:R:S346 99.122111.89YesNo088
18R:R:K61 R:R:L62 99.81435.64NoNo079
19R:R:E342 R:R:L62 99.72214.58NoNo079
20R:R:E342 R:R:S346 99.14574.31NoNo078
21R:R:F69 R:R:T158 17.26752.59YesYes097
22R:R:F69 R:R:N137 10.42847.25YesYes1299
23R:R:N137 R:R:Y149 11.32116.98YesNo1299
24R:R:L141 R:R:Y149 24.438515.24NoNo089
25A:A:C351 R:R:L141 24.87544.76NoNo048
26A:A:C351 R:R:R138 25.31186.96NoYes049
27R:R:R138 R:R:V134 35.5425.23YesNo099
28R:R:V134 R:R:Y336 35.84933.79NoNo099
29R:R:H131 R:R:Y336 36.190813.07YesNo099
30R:R:H131 R:R:N332 65.80916.38YesYes999
31R:R:D77 R:R:N332 85.220814.81YesYes999
32R:R:F69 R:R:Y153 10.4484.13YesYes1296
33R:R:Y149 R:R:Y153 12.67969.93NoYes1296
34R:R:L162 R:R:T158 14.55462.95NoYes077
35R:R:L162 R:R:N72 13.64926.87NoNo079
36R:R:N72 R:R:W166 12.74326.78NoNo098
37R:R:V126 R:R:W166 11.836712.26YesNo088
38R:R:F293 R:R:H131 19.96310.18YesYes999
39R:R:F293 R:R:L328 19.0344.87YesNo099
40R:R:L328 R:R:N332 19.70525.49NoYes099
41R:R:A135 R:R:L208 12.05163.15NoNo088
42R:R:A135 R:R:C211 11.7293.61NoYes087
43A:A:L353 R:R:R138 15.27863.64YesYes079
44R:R:C211 R:R:Y139 11.39294.03YesYes077
45A:A:L353 R:R:I215 11.23622.85YesNo079
46R:R:I142 R:R:I215 19.70015.89NoNo099
47A:A:L348 R:R:I142 19.0232.85YesNo099
48B:B:L70 B:B:W82 14.42945.69NoYes259
49B:B:L70 B:B:W63 14.87269.11NoYes257
50B:B:T321 B:B:W63 25.18389.7NoYes277
51B:B:D323 B:B:T321 25.61872.89NoNo277
52B:B:D323 B:B:M325 26.56114.16NoYes075
53B:B:M325 G:G:P49 42.06746.71YesNo057
54G:G:D48 G:G:P49 43.40723.22YesNo097
55B:B:S279 G:G:D48 45.18578.83NoYes099
56B:B:L284 B:B:S279 45.62894.5NoNo059
57B:B:L284 B:B:V296 46.07155.96NoNo055
58B:B:L286 B:B:V296 26.20472.98NoNo075
59B:B:C294 B:B:L286 25.9333.17NoNo057
60B:B:C294 B:B:L318 26.54913.17NoNo056
61B:B:L318 B:B:T329 27.89462.95NoNo068
62B:B:H311 B:B:T329 34.9585.48YesNo098
63B:B:D333 B:B:H311 43.35197.56YesYes899
64B:B:D333 B:B:F335 95.71114.78YesNo094
65B:B:F335 R:R:K61 1002.48NoNo047
66R:R:H191 R:R:P193 14.13919.83NoNo045
67R:R:A194 R:R:H191 17.66811.46NoNo044
68R:R:A194 R:R:G308 19.43181.95NoNo043
69R:R:G308 R:R:S307 21.1951.86NoNo034
70R:R:S304 R:R:S307 30.00221.63NoNo074
71R:R:A198 R:R:S304 31.76191.71NoNo047
72R:R:A198 R:R:V301 33.52111.7NoNo045
73R:R:L201 R:R:V301 17.63234.47NoNo055
74R:R:L201 R:R:T297 18.50792.95NoNo056
75R:R:F293 R:R:T297 40.5269.08YesNo096
76R:R:Q298 R:R:V301 17.64942.87YesNo065
77R:R:Q298 R:R:T297 21.15182.83YesNo066
78A:A:I344 A:A:L348 15.69682.85NoYes069
79A:A:I344 R:R:S222 15.6544.64NoNo068
80A:A:D341 R:R:V226 16.23435.84NoNo086
81R:R:S227 R:R:V226 15.89331.62NoNo056
82R:R:S227 R:R:V223 15.70051.62NoNo054
83R:R:S222 R:R:V223 15.62931.62NoNo084
84A:A:D341 A:A:Y320 17.38025.75NoYes087
85B:B:M325 G:G:P60 13.296.71YesYes059
86B:B:F199 B:B:L190 13.35114.87NoNo095
87B:B:F199 B:B:W211 13.726113.03NoYes498
88B:B:S201 B:B:W211 35.04156.18NoYes498
89B:B:S201 B:B:V187 35.29053.23NoNo499
90B:B:S160 B:B:V187 64.65074.85NoNo069
91B:B:S147 B:B:S160 65.35773.26NoNo096
92B:B:S147 B:B:Y145 65.71433.82NoYes098
93B:B:M101 B:B:Y145 62.37284.79NoYes098
94B:B:L117 B:B:M101 62.87082.83NoNo099
95B:B:L117 B:B:W99 63.12044.56NoYes099
96B:B:Q75 B:B:W99 69.87864.38NoYes199
97B:B:Q75 B:B:Y59 69.556615.78NoYes198
98B:B:W332 B:B:Y59 69.40877.72YesYes198
99B:B:N313 B:B:W332 84.96046.78NoYes079
100B:B:D333 B:B:N313 84.94064.04YesNo097
101B:B:C114 B:B:G115 10.75613.92YesNo089
102B:B:G115 B:B:T102 11.19221.82NoNo098
103B:B:C149 B:B:T102 11.66896.76NoNo088
104B:B:C121 B:B:C149 12.16151.82NoNo088
105B:B:C121 B:B:T159 12.26763.38NoYes089
106B:B:H142 B:B:T159 12.57096.85YesYes199
107B:B:H142 B:B:S161 26.368912.55YesNo199
108B:B:G162 B:B:S161 29.82933.71NoNo199
109B:B:G162 B:B:Y145 26.17324.35NoYes198
110A:A:I222 A:A:L36 22.37077.14NoNo077
111A:A:I222 A:A:I265 22.03422.94NoNo078
112A:A:A338 A:A:I265 21.44913.25NoNo068
113A:A:A338 A:A:Y320 20.86565.34NoYes067
114A:A:L36 A:A:V34 21.60722.98NoYes075
115A:A:F215 A:A:L37 35.60998.53YesNo099
116A:A:I253 A:A:L39 18.50144.28NoNo089
117A:A:F259 A:A:I253 18.49895.02YesNo098
118A:A:F259 A:A:N256 21.05584.83YesNo198
119A:A:N256 A:A:W258 38.81743.39NoYes185
120A:A:W258 B:B:W332 18.04714.69YesYes159
121A:A:K46 A:A:L38 20.43924.23YesYes098
122A:A:I222 A:A:L38 39.42722.85NoYes078
123A:A:I49 A:A:L38 20.14842.85NoYes078
124A:A:F223 A:A:L39 51.10463.65YesNo099
125A:A:F223 A:A:L249 17.42284.87YesNo099
126A:A:L249 A:A:R208 17.41463.64NoNo099
127A:A:I212 A:A:R208 17.41066.26NoNo089
128A:A:I212 A:A:N256 17.592.83NoNo188
129A:A:L268 A:A:V225 52.44212.98NoNo087
130A:A:L268 A:A:T321 57.15922.95NoYes085
131A:A:L266 A:A:T321 65.10274.42NoYes1095
132A:A:F223 A:A:L266 64.74193.65YesNo1099
133A:A:C224 A:A:N269 42.91323.15NoYes079
134A:A:C224 A:A:K46 21.89453.23NoYes079
135A:A:C224 A:A:I49 20.8773.27NoNo077
136A:A:Q204 A:A:W211 16.49529.86YesYes199
137A:A:F215 A:A:W211 37.02474.01YesYes199
138A:A:S206 A:A:W211 20.6744.94YesYes189
139A:A:F307 A:A:V225 51.31787.87NoNo087
140A:A:K270 A:A:S228 45.256110.71NoYes099
141A:A:K270 A:A:N269 45.0962.8NoYes099
142A:A:K277 A:A:Y230 45.29679.55YesYes698
143A:A:K277 A:A:S228 45.69624.59YesYes699
144A:A:M243 A:A:Y230 47.93555.99NoYes088
145A:A:M243 A:A:Y287 48.9423.59NoYes087
146A:A:F307 A:A:M247 51.05434.98NoNo086
147B:B:R314 B:B:W332 26.409218.99NoYes189
148B:B:H183 B:B:K209 26.434714.41YesYes496
149B:B:H183 B:B:V187 29.00798.3YesNo499
150B:B:L210 B:B:Q220 10.84296.65YesYes057
151B:B:L210 B:B:R219 34.10574.86YesYes055
152B:B:M217 B:B:R219 35.72066.2NoYes2535
153B:B:M217 G:G:M21 38.19984.33NoNo031
154G:G:M21 G:G:Q18 39.0174.08NoNo019
155B:B:C218 G:G:Q18 39.86796.1NoNo059
156B:B:C218 B:B:K209 19.86516.47NoYes456
157B:B:C218 B:B:W211 20.81115.22NoYes458
158B:B:W297 B:B:Y264 18.85746.75YesYes085
159B:B:W297 B:B:Y289 18.49187.72YesYes787
160B:B:C271 B:B:Y289 45.53924.03NoYes057
161B:B:C271 B:B:D290 46.14396.22NoNo056
162B:B:D290 B:B:R314 47.068121.44NoNo068
163B:B:D298 B:B:V40 10.59795.84NoYes093
164B:B:I43 B:B:V40 13.12853.07NoYes033
165B:B:I43 B:B:M45 13.98622.92NoYes034
166B:B:M45 B:B:W339 16.2443.49YesYes849
167B:B:K337 B:B:W339 11.64476.96YesYes869
168B:B:G306 B:B:V296 22.24551.84NoNo045
169B:B:H142 B:B:W169 11.48357.41YesYes198
170B:B:I232 B:B:V200 14.21346.14YesNo086
171B:B:L210 B:B:V200 20.83442.98YesNo056
172B:B:H225 B:B:T243 10.06538.21YesNo098
173B:B:I232 B:B:T243 10.88153.04YesNo088
174B:B:N295 B:B:Y289 22.507810.47YesYes767
175B:B:N295 B:B:V307 22.60154.43YesYes763
176B:B:G306 B:B:V307 22.28121.84NoYes043
177A:A:M247 A:A:Y287 50.28433.59NoYes067
178A:A:L37 A:A:L39 35.3185.54NoNo099
179A:A:W258 B:B:R314 20.96953YesNo158
180A:A:Q204 B:B:Y145 15.22754.51YesYes198
181A:A:S206 B:B:Y145 14.94735.09YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7WZ4
Class A
SubFamily Orphan
Type A orphans
SubType GPR88
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3
Date 2022-10-26
D.O.I. 10.1038/s41467-022-30081-5
Net Summary
Imin 2.8
Number of Linked Nodes 780
Number of Links 906
Number of Hubs 132
Number of Links mediated by Hubs 504
Number of Communities 25
Number of Nodes involved in Communities 181
Number of Links involved in Communities 245
Path Summary
Number Of Nodes in MetaPath 182
Number Of Links MetaPath 181
Number of Shortest Paths 832780
Length Of Smallest Path 3
Average Path Length 31.833
Length of Longest Path 62
Minimum Path Strength 1.12
Average Path Strength 5.66615
Maximum Path Strength 21.55
Minimum Path Correlation 0.7
Average Path Correlation 0.976762
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 42.8468
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.2159
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9GZN0
Sequence
>7WZ4_Chain_R
VSLLYSGLA IGGTLANGM VIYLVSSFR KLQTTSNAF IVNGCAADL 
SVCALWMPQ ERLLRGGLL GLGLTVSLL SHCLVALNR YLLITRAPA 
TYQALYQRR HTAGMLALS WALALGLVL LLPPWAVHY PALLAAAAL 
LAQTALLLH CYLGIVRRV RVSVKRVSR LSGLSVLLL CCVFLLATQ 
PLVWVSLAS GFSLPVPWG VQAASWLLC CALSALNPL LYTWRNEEF 
RRSVRSVL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7WZ4_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCAT DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7WZ4_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7WZ4_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EJXAOrphanA orphansGPR88Homo sapiens-(1R;2R)-2-PCCAGi1/&β;1/&γ;22.42022-04-1310.1038/s41467-022-30081-5
7WZ4AOrphanA orphansGPR88Homo sapiens--Gi1/&β;1/&γ;232022-10-2610.1038/s41467-022-30081-5




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Download 7WZ4.zip



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