psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I46	R:R:K48	10.18	No	No	0	5	4
2	R:R:N47	R:R:R294	7.23	No	No	0	4	2
3	R:R:F50	R:R:I54	10.05	No	No	0	5	5
4	R:R:V51	R:R:Y55	7.57	No	Yes	2	5	7
5	R:R:K108	R:R:V51	4.55	No	No	2	5	5
6	R:R:I301	R:R:I54	5.89	No	No	0	5	5
7	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
8	R:R:K108	R:R:Y55	5.97	No	Yes	2	5	7
9	R:R:I304	R:R:Y55	7.25	No	Yes	0	7	7
10	R:R:C308	R:R:V58	5.12	No	No	0	7	7
11	R:R:F59	R:R:L60	4.87	No	No	0	7	4
12	R:R:F59	R:R:L63	4.87	No	No	0	7	5
13	R:R:F59	R:R:P102	8.67	No	No	0	7	9
14	R:R:A98	R:R:S62	3.42	No	No	0	5	8
15	R:R:S307	R:R:S62	4.89	No	No	0	8	8
16	R:R:G65	R:R:P311	4.06	No	No	0	7	9
17	R:R:D94	R:R:N66	5.39	No	Yes	0	9	9
18	R:R:N66	R:R:P311	11.4	Yes	No	0	9	9
19	R:R:L325	R:R:L68	6.92	No	No	0	6	6
20	R:R:P311	R:R:V69	3.53	No	No	0	9	8
21	R:R:V69	R:R:Y314	5.05	No	Yes	1	8	9
22	R:R:F321	R:R:V69	5.24	Yes	No	1	8	8
23	R:R:F321	R:R:V72	7.87	Yes	Yes	0	8	7
24	R:R:I73	R:R:L88	11.42	No	No	0	6	5
25	R:R:I73	W:W:?1	5.03	No	Yes	0	6	0
26	R:R:L74	R:R:L88	6.92	No	No	0	2	5
27	R:R:I328	R:R:Y75	12.09	No	No	0	5	4
28	R:R:I331	R:R:Y75	3.63	No	No	3	2	4
29	R:R:H332	R:R:Y75	5.44	No	No	3	3	4
30	R:R:R77	R:R:R80	5.33	No	No	0	6	7
31	R:R:D84	R:R:R80	3.57	Yes	No	0	8	7
32	R:R:D84	R:R:S81	8.83	Yes	No	1	8	7
33	R:R:S81	W:W:?1	10.59	No	Yes	1	7	0
34	R:R:V82	R:R:Y86	5.05	Yes	Yes	1	7	7
35	R:R:D143	R:R:V82	10.22	No	Yes	0	8	7
36	R:R:R159	R:R:V82	3.92	No	Yes	0	3	7
37	R:R:V162	R:R:V82	4.81	Yes	Yes	1	7	7
38	R:R:I140	R:R:T83	6.08	Yes	No	1	9	7
39	R:R:R144	R:R:T83	5.17	Yes	No	1	9	7
40	R:R:T83	W:W:?1	11.27	No	Yes	1	7	0
41	R:R:D84	R:R:K320	8.3	Yes	No	1	8	6
42	R:R:D84	W:W:?1	19.15	Yes	Yes	1	8	0
43	R:R:L136	R:R:Y86	3.52	No	Yes	0	8	7
44	R:R:C139	R:R:Y86	9.41	No	Yes	0	5	7
45	R:R:I140	R:R:Y86	4.84	Yes	Yes	1	9	7
46	R:R:V162	R:R:Y86	3.79	Yes	Yes	1	7	7
47	R:R:I165	R:R:Y86	7.25	No	Yes	0	5	7
48	R:R:L87	R:R:Y314	5.86	No	Yes	1	7	9
49	R:R:L87	W:W:?1	4.07	No	Yes	1	7	0
50	R:R:L136	R:R:N89	5.49	No	No	0	8	9
51	R:R:C166	R:R:N89	9.45	No	No	0	7	9
52	R:R:N89	R:R:W170	5.65	No	Yes	0	9	9
53	R:R:L90	R:R:N310	4.12	No	Yes	0	9	9
54	R:R:L92	R:R:L96	4.15	No	No	0	6	7
55	R:R:L92	R:R:W170	6.83	No	Yes	0	6	9
56	R:R:D94	R:R:H306	6.3	No	Yes	0	9	9
57	R:R:D94	R:R:S307	5.89	No	No	0	9	8
58	R:R:F97	R:R:N129	15.71	No	No	0	6	8
59	R:R:F97	R:R:S307	7.93	No	No	0	6	8
60	R:R:T100	R:R:W104	3.64	No	Yes	2	7	6
61	R:R:T100	R:R:V122	11.11	No	No	2	7	5
62	R:R:L125	R:R:T100	4.42	No	No	0	4	7
63	R:R:I304	R:R:L101	4.28	No	No	0	7	8
64	R:R:I103	R:R:W112	3.52	No	Yes	0	6	9
65	R:R:S107	R:R:W104	4.94	No	Yes	0	5	6
66	R:R:V122	R:R:W104	6.13	No	Yes	2	5	6
67	R:R:K126	R:R:W104	6.96	No	Yes	0	6	6
68	R:R:S107	R:R:W112	4.94	No	Yes	0	5	9
69	R:R:E300	R:R:K108	4.05	No	No	0	5	5
70	R:R:N110	R:R:V109	7.39	No	No	0	4	4
71	R:R:F114	R:R:W112	15.03	Yes	Yes	2	6	9
72	R:R:L118	R:R:W112	4.56	No	Yes	2	6	9
73	R:R:C119	R:R:W112	3.92	No	Yes	2	9	9
74	R:R:V122	R:R:W112	4.9	No	Yes	2	5	9
75	R:R:C196	R:R:W112	11.75	No	Yes	2	9	9
76	R:R:F114	R:R:L118	3.65	Yes	No	2	6	6
77	R:R:R185	R:R:T116	3.88	No	No	0	4	3
78	R:R:T116	R:R:T186	4.71	No	No	0	3	4
79	R:R:F117	R:R:V121	7.87	No	No	0	1	5
80	R:R:C119	R:R:C196	5.46	No	No	2	9	9
81	R:R:R184	R:R:S123	9.22	Yes	No	0	5	5
82	R:R:L124	R:R:L174	4.15	No	No	0	6	5
83	R:R:L124	R:R:L181	5.54	No	No	0	6	5
84	R:R:K126	R:R:R184	6.19	No	Yes	0	6	5
85	R:R:E127	R:R:Y131	10.1	No	Yes	0	4	7
86	R:R:E127	R:R:V180	7.13	No	No	0	4	4
87	R:R:E127	R:R:R212	4.65	No	Yes	0	4	5
88	R:R:S173	R:R:V128	6.46	No	No	0	7	5
89	R:R:F130	R:R:Y131	5.16	Yes	Yes	0	7	7
90	R:R:F130	R:R:I134	5.02	Yes	No	0	7	8
91	R:R:F130	R:R:W264	16.04	Yes	No	0	7	8
92	R:R:F130	R:R:N268	6.04	Yes	No	0	7	8
93	R:R:L176	R:R:Y131	15.24	No	Yes	5	4	7
94	R:R:P215	R:R:Y131	6.95	Yes	Yes	5	5	7
95	R:R:G133	R:R:S132	3.71	No	No	0	9	6
96	R:R:S132	R:R:W170	3.71	No	Yes	0	6	9
97	R:R:S132	R:R:S173	4.89	No	No	0	6	7
98	R:R:G133	R:R:L136	3.42	No	No	0	9	8
99	R:R:I134	R:R:P223	5.08	No	Yes	0	8	9
100	R:R:F260	R:R:I134	7.54	Yes	No	0	9	8
101	R:R:I169	R:R:W135	4.7	No	No	0	6	6
102	R:R:L172	R:R:W135	6.83	No	No	0	4	6
103	R:R:P223	R:R:W135	20.27	Yes	No	0	9	6
104	R:R:F260	R:R:L137	8.53	Yes	No	0	9	8
105	R:R:I140	R:R:Y231	3.63	Yes	Yes	1	9	9
106	R:R:I140	R:R:I253	4.42	Yes	Yes	1	9	7
107	R:R:C230	R:R:S141	3.44	No	No	0	7	9
108	R:R:S141	R:R:Y231	13.99	No	Yes	0	9	9
109	R:R:D143	R:R:R144	5.96	No	Yes	0	8	9
110	R:R:D143	R:R:T154	7.23	No	No	0	8	5
111	R:R:A147	R:R:R144	4.15	No	Yes	0	8	9
112	R:R:M250	R:R:R144	7.44	No	Yes	0	5	9
113	R:R:R144	W:W:?1	9.29	Yes	Yes	1	9	0
114	R:R:V149	R:R:Y145	8.83	No	Yes	6	7	8
115	R:R:H150	R:R:Y145	10.89	No	Yes	6	6	8
116	R:R:C230	R:R:Y145	8.06	No	Yes	0	7	8
117	R:R:T234	R:R:Y145	3.75	No	Yes	0	8	8
118	R:R:L146	R:R:T154	4.42	No	No	0	5	5
119	R:R:I148	R:R:T234	6.08	No	No	0	8	8
120	R:R:I148	R:R:L238	4.28	No	No	0	8	8
121	R:R:I148	R:R:K246	10.18	No	No	0	8	7
122	R:R:H150	R:R:V149	6.92	No	No	6	6	7
123	R:R:T237	R:R:V149	9.52	No	No	0	5	7
124	R:R:L155	R:R:V162	4.47	No	Yes	0	4	7
125	R:R:I165	R:R:L155	4.28	No	No	0	5	4
126	R:R:K158	R:R:Y160	10.75	No	No	7	6	5
127	R:R:K158	R:R:L161	7.05	No	No	7	6	4
128	R:R:L161	R:R:Y160	16.41	No	No	7	4	5
129	R:R:F164	R:R:Y160	4.13	No	No	0	3	5
130	R:R:L176	R:R:P215	4.93	No	Yes	5	4	5
131	R:R:G219	R:R:L176	3.42	No	No	0	5	4
132	R:R:L211	R:R:P179	9.85	No	No	0	4	8
133	R:R:R184	R:R:V180	3.92	Yes	No	4	5	4
134	R:R:E198	R:R:V180	4.28	Yes	No	4	5	4
135	R:R:F183	R:R:L182	4.87	Yes	No	0	5	4
136	R:R:E198	R:R:F183	7	Yes	Yes	0	5	5
137	R:R:F183	R:R:R208	12.83	Yes	No	0	5	4
138	R:R:F183	R:R:L211	4.87	Yes	No	0	5	4
139	R:R:E198	R:R:R184	5.82	Yes	Yes	4	5	5
140	R:R:T186	R:R:Y188	4.99	No	No	0	4	1
141	R:R:V187	R:R:Y197	13.88	No	Yes	0	3	3
142	R:R:P194	R:R:Y188	5.56	No	No	0	5	1
143	R:R:A195	R:R:Y197	4	No	Yes	0	3	3
144	R:R:E198	R:R:R212	6.98	Yes	Yes	0	5	5
145	R:R:I213	R:R:M209	4.37	No	No	0	4	3
146	R:R:P215	R:R:R212	5.76	Yes	Yes	0	5	5
147	R:R:I213	R:R:Q216	4.12	No	No	0	4	5
148	R:R:I221	R:R:S217	6.19	No	No	0	4	4
149	R:R:F218	R:R:V222	3.93	No	No	0	4	5
150	R:R:G219	R:R:P223	4.06	No	Yes	0	5	9
151	R:R:F220	R:R:I221	3.77	No	No	0	8	4
152	R:R:F220	R:R:N268	8.46	No	No	0	8	8
153	R:R:P223	R:R:V222	3.53	Yes	No	0	9	5
154	R:R:L224	R:R:L228	4.15	No	No	0	7	4
155	R:R:F229	R:R:L225	3.65	No	No	0	4	3
156	R:R:M227	R:R:Y231	5.99	No	Yes	0	8	9
157	R:R:I253	R:R:Y231	3.63	Yes	Yes	1	7	9
158	R:R:F254	R:R:Y231	6.19	No	Yes	0	4	9
159	R:R:V257	R:R:Y231	10.09	No	Yes	0	7	9
160	R:R:F239	R:R:L235	6.09	No	No	0	5	4
161	R:R:F254	R:R:L235	9.74	No	No	0	4	4
162	R:R:K240	R:R:T237	4.5	No	No	0	5	5
163	R:R:H247	R:R:L238	6.43	No	No	0	5	8
164	R:R:R248	R:R:R251	13.86	No	No	0	7	5
165	R:R:E249	R:R:K320	6.75	No	No	1	7	6
166	R:R:E249	W:W:?1	10.91	No	Yes	1	7	0
167	R:R:I253	R:R:M250	5.83	Yes	No	0	7	5
168	R:R:F254	R:R:M250	7.46	No	No	0	4	5
169	R:R:I317	R:R:R251	3.76	Yes	No	0	6	5
170	R:R:G318	R:R:V252	3.68	No	No	0	7	7
171	R:R:V252	W:W:?1	3.5	No	Yes	0	7	0
172	R:R:I253	W:W:?1	4.2	Yes	Yes	1	7	0
173	R:R:N310	R:R:V256	5.91	Yes	No	1	9	8
174	R:R:V256	R:R:Y314	3.79	No	Yes	1	8	9
175	R:R:L258	R:R:L262	4.15	No	No	0	5	5
176	R:R:I259	R:R:L309	4.28	No	No	0	6	6
177	R:R:F260	R:R:W264	10.02	Yes	No	0	9	8
178	R:R:F260	R:R:H306	11.31	Yes	Yes	0	9	9
179	R:R:C263	R:R:H306	7.37	No	Yes	0	7	9
180	R:R:A303	R:R:W264	7.78	No	No	0	7	8
181	R:R:L265	R:R:L269	5.54	No	No	0	6	6
182	R:R:P266	R:R:T299	3.5	No	No	0	9	6
183	R:R:L271	R:R:Y267	4.69	No	Yes	0	6	7
184	R:R:L296	R:R:Y267	4.69	No	Yes	0	5	7
185	R:R:T299	R:R:Y267	7.49	No	Yes	0	6	7
186	R:R:E300	R:R:Y267	4.49	No	Yes	0	5	7
187	R:R:L296	R:R:V270	4.47	No	No	0	5	4
188	R:R:T299	R:R:V270	4.76	No	No	0	6	4
189	R:R:D274	R:R:I292	12.59	No	No	0	4	5
190	R:R:D274	R:R:L296	4.07	No	No	0	4	5
191	R:R:L276	R:R:T279	4.42	No	No	0	4	1
192	R:R:M277	R:R:R289	3.72	No	No	0	4	3
193	R:R:H306	R:R:N310	7.65	Yes	Yes	0	9	9
194	R:R:N310	R:R:Y314	8.14	Yes	Yes	1	9	9
195	R:R:F321	R:R:Y314	4.13	Yes	Yes	1	8	9
196	R:R:Y314	W:W:?1	4.82	Yes	Yes	1	9	0
197	R:R:Q319	R:R:R322	7.01	No	No	0	5	8
198	R:R:H323	R:R:Q319	3.71	No	No	0	4	5
199	R:R:K320	W:W:?1	30.68	No	Yes	1	6	0
200	R:R:F321	W:W:?1	4.3	Yes	Yes	1	8	0
201	R:R:L329	R:R:L334	8.3	No	No	0	6	1
202	R:R:H332	R:R:I331	9.28	No	No	3	3	2
203	R:R:S76	R:R:V78	3.23	No	No	0	4	5
204	R:R:V162	R:R:V85	3.21	Yes	No	0	7	6
205	R:R:C308	R:R:L61	3.17	No	No	0	7	5
206	R:R:A91	R:R:N66	3.13	No	Yes	0	8	9
207	R:R:I335	R:R:S336	3.1	No	No	0	4	8
208	R:R:I304	R:R:V58	3.07	No	No	0	7	7
209	R:R:I328	R:R:V72	3.07	No	Yes	0	5	7
210	R:R:I317	R:R:V252	3.07	Yes	No	0	6	7
211	R:R:L305	R:R:V58	2.98	No	No	0	5	7
212	R:R:L325	R:R:V72	2.98	No	Yes	0	6	7
213	R:R:L124	R:R:V128	2.98	No	No	0	6	5
214	R:R:N191	R:R:S190	2.98	No	No	0	2	2
215	R:R:L261	R:R:V257	2.98	No	No	0	6	7
216	R:R:L146	R:R:T152	2.95	No	No	0	5	5
217	R:R:I259	R:R:I313	2.94	No	No	0	6	7
218	R:R:I313	R:R:I317	2.94	No	Yes	8	7	6
219	R:R:L88	R:R:M70	2.83	No	No	0	5	6
220	R:R:L92	R:R:M70	2.83	No	No	0	6	6
221	R:R:L57	R:R:L61	2.77	No	No	0	5	5
222	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
223	R:R:L155	R:R:L161	2.77	No	No	0	4	4
224	R:R:L95	R:R:N66	2.75	No	Yes	0	7	9
225	R:R:L272	R:R:Q216	2.66	No	No	0	5	5
226	R:R:F50	R:R:V51	2.62	No	No	0	5	5
227	R:R:A93	R:R:W170	2.59	No	Yes	0	8	9
228	R:R:F114	R:R:I113	2.51	Yes	No	0	6	3
229	R:R:I292	R:R:R289	2.51	No	No	0	5	3
230	R:R:M209	R:R:R212	2.48	No	Yes	0	3	5
231	R:R:K240	R:R:R236	2.48	No	No	0	5	4
232	R:R:F117	R:R:L118	2.44	No	No	0	1	6
233	R:R:F220	R:R:L265	2.44	No	No	0	8	6
234	R:R:F316	R:R:L312	2.44	No	No	0	6	6
235	R:R:T186	R:R:W112	2.43	No	Yes	0	4	9
236	R:R:L210	R:R:W207	2.28	No	No	0	2	3
237	R:R:F233	R:R:Y145	2.06	No	Yes	0	4	8
238	R:R:R184	R:R:Y197	2.06	Yes	Yes	0	5	3
239	R:R:G111	R:R:P194	2.03	No	No	0	4	5
240	R:R:W104	R:R:Y55	1.93	Yes	Yes	2	6	7
241	R:R:A138	R:R:P223	1.87	No	Yes	0	7	9
242	R:R:G111	R:R:S193	1.86	No	No	0	4	3
243	R:R:G324	R:R:V72	1.84	No	Yes	0	5	7
244	R:R:G79	R:R:V78	1.84	No	No	0	6	5
245	R:R:G244	R:R:K246	1.74	No	No	0	4	7
246	R:R:G324	R:R:K327	1.74	No	No	0	5	4
247	R:R:G65	R:R:L64	1.71	No	No	0	7	4
248	R:R:G171	R:R:L174	1.71	No	No	0	4	5
249	R:R:A105	R:R:V52	1.7	No	No	0	7	5
250	R:R:G111	R:R:N110	1.7	No	No	0	4	4
251	R:R:A177	R:R:V128	1.7	No	No	0	7	5
252	R:R:L101	R:R:P102	1.64	No	No	0	8	9
253	R:R:L178	R:R:P179	1.64	No	No	0	3	8
254	R:R:L214	R:R:P215	1.64	No	Yes	0	3	5
255	R:R:C230	R:R:I226	1.64	No	No	0	7	6
256	R:R:L302	R:R:P266	1.64	No	No	0	7	9
257	R:R:A255	R:R:I313	1.62	No	No	8	5	7
258	R:R:A255	R:R:I317	1.62	No	Yes	8	5	6
259	R:R:A273	R:R:I292	1.62	No	No	0	5	5
260	R:R:G333	R:R:H332	1.59	No	No	0	3	3
261	R:R:I226	R:R:V142	1.54	No	No	0	6	6
262	R:R:L63	R:R:S67	1.5	No	No	0	5	3
263	R:R:L95	R:R:S67	1.5	No	No	0	7	3
264	R:R:L71	R:R:V72	1.49	No	Yes	0	3	7
265	R:R:I53	R:R:I54	1.47	No	No	0	5	5
266	R:R:I221	R:R:L225	1.43	No	No	0	4	3
267	R:R:G115	R:R:W112	1.41	No	Yes	0	8	9
268	R:R:K120	R:R:L181	1.41	No	No	0	7	5
269	R:R:A315	R:R:F321	1.39	No	Yes	0	7	8
270	R:R:L312	R:R:L61	1.38	No	No	0	6	5
271	R:R:L96	R:R:L99	1.38	No	No	0	7	4
272	R:R:A147	R:R:R153	1.38	No	No	0	8	5
273	R:R:L224	R:R:L261	1.38	No	No	0	7	6
274	R:R:L272	R:R:L276	1.38	No	No	0	5	4
275	R:R:L325	R:R:L329	1.38	No	No	0	6	6
276	R:R:L326	R:R:L329	1.38	No	No	0	4	6
277	R:R:R153	R:R:T156	1.29	No	No	0	5	2
278	R:R:S189	R:R:Y197	1.27	No	Yes	0	1	3
279	R:R:H247	R:R:Q245	1.24	No	No	0	5	4
280	R:R:D297	R:R:R294	1.19	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y55	5.344	5	2	7
2	R:R:N66	5.6675	4	0	9
3	R:R:V72	3.45	5	0	7
4	R:R:V82	6	4	1	7
5	R:R:D84	9.9625	4	1	8
6	R:R:Y86	5.64333	6	1	7
7	R:R:W104	4.72	5	2	6
8	R:R:W112	5.82889	9	2	9
9	R:R:F114	5.99	4	2	6
10	R:R:F130	8.065	4	0	7
11	R:R:Y131	9.3625	4	5	7
12	R:R:I140	4.7425	4	1	9
13	R:R:R144	6.402	5	1	9
14	R:R:Y145	6.718	5	6	8
15	R:R:V162	4.07	4	1	7
16	R:R:W170	4.695	4	0	9
17	R:R:F183	7.3925	4	0	5
18	R:R:R184	5.442	5	4	5
19	R:R:Y197	5.3025	4	0	3
20	R:R:E198	6.02	4	4	5
21	R:R:R212	4.9675	4	0	5
22	R:R:P215	4.82	4	5	5
23	R:R:P223	6.962	5	0	9
24	R:R:Y231	7.25333	6	1	9
25	R:R:I253	4.52	4	1	7
26	R:R:F260	9.35	4	0	9
27	R:R:Y267	5.34	4	0	7
28	R:R:H306	8.1575	4	0	9
29	R:R:N310	6.455	4	1	9
30	R:R:Y314	5.29833	6	1	9
31	R:R:I317	2.8475	4	8	6
32	R:R:F321	4.586	5	1	8
33	W:W:?1	9.8175	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I304	R:R:Y55	26.5372	7.25	No	Yes	0	7	7
2	R:R:I304	R:R:L101	30.6245	4.28	No	No	0	7	8
3	R:R:L101	R:R:P102	31.148	1.64	No	No	0	8	9
4	R:R:F59	R:R:P102	31.7753	8.67	No	No	0	7	9
5	R:R:F59	R:R:L63	33.0956	4.87	No	No	0	7	5
6	R:R:L95	R:R:N66	35.4706	2.75	No	Yes	0	7	9
7	R:R:L95	R:R:S67	34.5474	1.5	No	No	0	7	3
8	R:R:L63	R:R:S67	33.776	1.5	No	No	0	5	3
9	R:R:N66	R:R:P311	35.2505	11.4	Yes	No	0	9	9
10	R:R:P311	R:R:V69	35.9486	3.53	No	No	0	9	8
11	R:R:F321	R:R:V69	19.9863	5.24	Yes	No	1	8	8
12	R:R:F321	R:R:V72	16.5617	7.87	Yes	Yes	0	8	7
13	R:R:V69	R:R:Y314	16.8425	5.05	No	Yes	1	8	9
14	R:R:Y314	W:W:?1	100	4.82	Yes	Yes	1	9	0
15	R:R:I73	W:W:?1	16.9639	5.03	No	Yes	0	6	0
16	R:R:F321	W:W:?1	21.9971	4.3	Yes	Yes	1	8	0
17	R:R:I73	R:R:L88	16.0154	11.42	No	No	0	6	5
18	R:R:R144	W:W:?1	19.0328	9.29	Yes	Yes	1	9	0
19	R:R:D143	R:R:R144	12.9828	5.96	No	Yes	0	8	9
20	R:R:T83	W:W:?1	26.4006	11.27	No	Yes	1	7	0
21	R:R:I140	R:R:T83	26.4335	6.08	Yes	No	1	9	7
22	R:R:I140	R:R:Y86	52.5179	4.84	Yes	Yes	1	9	7
23	R:R:I253	W:W:?1	54.7512	4.2	Yes	Yes	1	7	0
24	R:R:I140	R:R:I253	25.662	4.42	Yes	Yes	1	9	7
25	R:R:V162	R:R:Y86	13.2585	3.79	Yes	Yes	1	7	7
26	R:R:L136	R:R:Y86	25.7809	3.52	No	Yes	0	8	7
27	R:R:I165	R:R:Y86	11.1743	7.25	No	Yes	0	5	7
28	R:R:L88	R:R:M70	13.9414	2.83	No	No	0	5	6
29	R:R:L92	R:R:M70	13.0106	2.83	No	No	0	6	6
30	R:R:L92	R:R:W170	10.4611	6.83	No	Yes	0	6	9
31	R:R:H306	R:R:N310	95.2095	7.65	Yes	Yes	0	9	9
32	R:R:W104	R:R:Y55	13.8149	1.93	Yes	Yes	2	6	7
33	R:R:K126	R:R:W104	53.3399	6.96	No	Yes	0	6	6
34	R:R:K126	R:R:R184	54.1948	6.19	No	Yes	0	6	5
35	R:R:R184	R:R:V180	53.8685	3.92	Yes	No	4	5	4
36	R:R:E127	R:R:V180	61.1554	7.13	No	No	0	4	4
37	R:R:E127	R:R:Y131	75.1701	10.1	No	Yes	0	4	7
38	R:R:F130	R:R:Y131	90.1687	5.16	Yes	Yes	0	7	7
39	R:R:F130	R:R:I134	48.772	5.02	Yes	No	0	7	8
40	R:R:F260	R:R:I134	51.5087	7.54	Yes	No	0	9	8
41	R:R:F260	R:R:H306	98.7227	11.31	Yes	Yes	0	9	9
42	R:R:F130	R:R:W264	47.4391	16.04	Yes	No	0	7	8
43	R:R:F260	R:R:W264	47.7173	10.02	Yes	No	0	9	8
44	R:R:V122	R:R:W104	25.4723	6.13	No	Yes	2	5	6
45	R:R:S107	R:R:W104	25.5937	4.94	No	Yes	0	5	6
46	R:R:S107	R:R:W112	24.4151	4.94	No	Yes	0	5	9
47	R:R:V122	R:R:W112	24.5137	4.9	No	Yes	2	5	9
48	R:R:E300	R:R:K108	16.63	4.05	No	No	0	5	5
49	R:R:T186	R:R:W112	22.374	2.43	No	Yes	0	4	9
50	R:R:T186	R:R:Y188	14.9607	4.99	No	No	0	4	1
51	R:R:P194	R:R:Y188	12.4795	5.56	No	No	0	5	1
52	R:R:S132	R:R:S173	22.8014	4.89	No	No	0	6	7
53	R:R:S173	R:R:V128	19.9686	6.46	No	No	0	7	5
54	R:R:L124	R:R:V128	14.2879	2.98	No	No	0	6	5
55	R:R:G133	R:R:L136	19.306	3.42	No	No	0	9	8
56	R:R:G133	R:R:S132	17.4115	3.71	No	No	0	9	6
57	R:R:E198	R:R:R212	17.5254	6.98	Yes	Yes	0	5	5
58	R:R:F130	R:R:N268	10.3751	6.04	Yes	No	0	7	8
59	R:R:P215	R:R:R212	16.1039	5.76	Yes	Yes	0	5	5
60	R:R:I253	R:R:Y231	25.4116	3.63	Yes	Yes	1	7	9
61	R:R:C230	R:R:S141	19.0884	3.44	No	No	0	7	9
62	R:R:S141	R:R:Y231	20.1659	13.99	No	Yes	0	9	9
63	R:R:C230	R:R:Y145	15.8257	8.06	No	Yes	0	7	8
64	R:R:L155	R:R:V162	14.255	4.47	No	Yes	0	4	7
65	R:R:L155	R:R:L161	19.1087	2.77	No	No	0	4	4
66	R:R:E198	R:R:F183	18.7849	7	Yes	Yes	0	5	5
67	R:R:M209	R:R:R212	13.0738	2.48	No	Yes	0	3	5
68	R:R:I213	R:R:M209	10.8708	4.37	No	No	0	4	3
69	R:R:V252	W:W:?1	10.7014	3.5	No	Yes	0	7	0
70	R:R:E300	R:R:Y267	15.4943	4.49	No	Yes	0	5	7
71	R:R:K108	R:R:Y55	17.5178	5.97	No	Yes	2	5	7
72	R:R:P215	R:R:Y131	15.2945	6.95	Yes	Yes	5	5	7
73	R:R:N310	R:R:Y314	93.692	8.14	Yes	Yes	1	9	9
74	R:R:E127	R:R:R212	13.2964	4.65	No	Yes	0	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V69	R:R:Y314	5.05	1	No	Yes	8	9	2	1
R:R:F321	R:R:V69	5.24	1	Yes	No	8	8	1	2
R:R:F321	R:R:V72	7.87	1	Yes	Yes	8	7	1	2
R:R:I73	R:R:L88	11.42	0	No	No	6	5	1	2
R:R:I73	W:W:?1	5.03	0	No	Yes	6	0	1	0
R:R:D84	R:R:R80	3.57	1	Yes	No	8	7	1	2
R:R:D84	R:R:S81	8.83	1	Yes	No	8	7	1	1
R:R:S81	W:W:?1	10.59	1	No	Yes	7	0	1	0
R:R:I140	R:R:T83	6.08	1	Yes	No	9	7	2	1
R:R:R144	R:R:T83	5.17	1	Yes	No	9	7	1	1
R:R:T83	W:W:?1	11.27	1	No	Yes	7	0	1	0
R:R:D84	R:R:K320	8.3	1	Yes	No	8	6	1	1
R:R:D84	W:W:?1	19.15	1	Yes	Yes	8	0	1	0
R:R:L87	R:R:Y314	5.86	1	No	Yes	7	9	1	1
R:R:L87	W:W:?1	4.07	1	No	Yes	7	0	1	0
R:R:I140	R:R:Y231	3.63	1	Yes	Yes	9	9	2	2
R:R:I140	R:R:I253	4.42	1	Yes	Yes	9	7	2	1
R:R:D143	R:R:R144	5.96	0	No	Yes	8	9	2	1
R:R:A147	R:R:R144	4.15	0	No	Yes	8	9	2	1
R:R:M250	R:R:R144	7.44	0	No	Yes	5	9	2	1
R:R:R144	W:W:?1	9.29	1	Yes	Yes	9	0	1	0
R:R:I253	R:R:Y231	3.63	1	Yes	Yes	7	9	1	2
R:R:E249	R:R:K320	6.75	1	No	No	7	6	1	1
R:R:E249	W:W:?1	10.91	1	No	Yes	7	0	1	0
R:R:I253	R:R:M250	5.83	1	Yes	No	7	5	1	2
R:R:G318	R:R:V252	3.68	0	No	No	7	7	2	1
R:R:V252	W:W:?1	3.5	0	No	Yes	7	0	1	0
R:R:I253	W:W:?1	4.2	1	Yes	Yes	7	0	1	0
R:R:N310	R:R:V256	5.91	1	Yes	No	9	8	2	2
R:R:V256	R:R:Y314	3.79	1	No	Yes	8	9	2	1
R:R:N310	R:R:Y314	8.14	1	Yes	Yes	9	9	2	1
R:R:F321	R:R:Y314	4.13	1	Yes	Yes	8	9	1	1
R:R:Y314	W:W:?1	4.82	1	Yes	Yes	9	0	1	0
R:R:K320	W:W:?1	30.68	1	No	Yes	6	0	1	0
R:R:F321	W:W:?1	4.3	1	Yes	Yes	8	0	1	0
R:R:I317	R:R:V252	3.07	8	Yes	No	6	7	2	1
R:R:A315	R:R:F321	1.39	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
73.33	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
73.33	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
53.85	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
53.33	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
53.33	Consensus	ccr7_off_allo	Other Ligand	6QZH-CCR7-HY-133073; Na
37.50	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
30.77	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
27.78	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
26.32	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
26.32	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
21.43	Single	3VG9	Antibody	3VG9-A_2A-ZM241385-Antibody
20.00	Single	3VGA	Antibody	3VGA-A_2A-ZM241385-Antibody
19.05	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.00	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
14.29	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
13.04	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
10.53	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
9.52	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
9.09	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
8.70	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
8.70	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
6.67	Single	4PXF	Octyl Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
5.88	Single	7EB2	rac-BHFF	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.88	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
5.88	Consensus	gabab_on	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.88	Consensus	gi_class-c	Other Ligand	gi_mglu gi_gaba
5.56	Consensus	gi_gaba	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
5.26	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
5.26	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
5.26	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
5.00	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
5.00	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
5.00	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
4.76	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
4.76	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
4.55	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
4.55	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
4.35	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
4.00	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
3.85	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2

PDB Summary
PDB	6LFL
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR2
Species	Homo sapiens
Ligand	-
Other Ligand(s)	PubChem 153466996
Protein Partners	-
PDB Resolution	3.2
Date	2020-09-02
D.O.I.	10.1038/s41586-020-2492-5

Net Summary
I_min	3.42
Number of Linked Nodes	254
Number of Links	280
Number of Hubs	33
Number of Links mediated by Hubs	133
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	74801
Length Of Smallest Path	3
Average Path Length	16.0536
Length of Longest Path	32
Minimum Path Strength	1.335
Average Path Strength	6.15003
Maximum Path Strength	20.975
Minimum Path Correlation	0.7
Average Path Correlation	0.925418
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	42.3114
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.7832
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	EBX
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	EBX
Name	4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide
Synonyms
Identifier	4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide
Formula	C22 H26 N4 O5
Molecular Weight	426.466
SMILES	CC[C@H](c1cc(co1)C(C)C)NC2=C(C(=O)C2=O)Nc3ccnc(c3O)C(=O)N(C)C
PubChem	153466996
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	1
Total Bonds	59
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>6LFL_Chain_R I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I W L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A G Q K H R E M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T R N H I D R A L D A T E I L A I L H S C L N P L I Y A F I G Q K F R H G L L K I L A I H G L I S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/&β;1/&γ;2	3.5	2020-09-02	10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/&β;1/&γ;2	3.4	2020-09-02	10.1038/s41586-020-2492-5

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LFL.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.