psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I46	R:R:K48	10.18	No	No	0	5	4
2	R:R:N47	R:R:R294	7.23	No	No	0	4	2
3	R:R:I53	R:R:Y49	12.09	No	No	0	5	2
4	R:R:F50	R:R:I54	10.05	No	No	0	5	5
5	R:R:V51	R:R:Y55	7.57	No	Yes	3	5	7
6	R:R:K108	R:R:V51	4.55	No	No	3	5	5
7	R:R:I301	R:R:I54	5.89	No	No	0	5	5
8	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
9	R:R:K108	R:R:Y55	5.97	No	Yes	3	5	7
10	R:R:I304	R:R:Y55	7.25	No	Yes	0	7	7
11	R:R:C308	R:R:V58	5.12	No	No	0	7	7
12	R:R:F59	R:R:L60	4.87	No	No	0	7	4
13	R:R:F59	R:R:L63	4.87	No	No	0	7	5
14	R:R:F59	R:R:P102	8.67	No	No	0	7	9
15	R:R:S307	R:R:S62	4.89	No	No	0	8	8
16	R:R:G65	R:R:P311	4.06	No	No	0	7	9
17	R:R:D94	R:R:N66	5.39	No	Yes	0	9	9
18	R:R:N66	R:R:P311	11.4	Yes	No	0	9	9
19	R:R:L325	R:R:L68	6.92	No	No	0	6	6
20	R:R:P311	R:R:V69	3.53	No	No	0	9	8
21	R:R:V69	R:R:Y314	5.05	No	Yes	1	8	9
22	R:R:F321	R:R:V69	5.24	Yes	No	1	8	8
23	R:R:F321	R:R:V72	7.87	Yes	Yes	0	8	7
24	R:R:I73	R:R:L88	11.42	No	No	0	6	5
25	R:R:I73	W:W:?1	5.03	No	Yes	0	6	0
26	R:R:L74	R:R:L88	6.92	No	No	0	2	5
27	R:R:I328	R:R:Y75	12.09	No	No	0	5	4
28	R:R:I331	R:R:Y75	3.63	No	No	4	2	4
29	R:R:H332	R:R:Y75	5.44	No	No	4	3	4
30	R:R:R77	R:R:R80	5.33	No	No	0	6	7
31	R:R:D84	R:R:R80	3.57	Yes	No	0	8	7
32	R:R:D84	R:R:S81	8.83	Yes	No	1	8	7
33	R:R:S81	W:W:?1	10.59	No	Yes	1	7	0
34	R:R:V82	R:R:Y86	5.05	Yes	Yes	1	7	7
35	R:R:D143	R:R:V82	10.22	No	Yes	0	8	7
36	R:R:R159	R:R:V82	3.92	No	Yes	0	3	7
37	R:R:V162	R:R:V82	4.81	Yes	Yes	1	7	7
38	R:R:I140	R:R:T83	6.08	Yes	No	1	9	7
39	R:R:R144	R:R:T83	5.17	Yes	No	1	9	7
40	R:R:T83	W:W:?1	11.27	No	Yes	1	7	0
41	R:R:D84	R:R:K320	8.3	Yes	No	1	8	6
42	R:R:D84	W:W:?1	19.15	Yes	Yes	1	8	0
43	R:R:L136	R:R:Y86	3.52	No	Yes	0	8	7
44	R:R:C139	R:R:Y86	9.41	No	Yes	0	5	7
45	R:R:I140	R:R:Y86	4.84	Yes	Yes	1	9	7
46	R:R:V162	R:R:Y86	3.79	Yes	Yes	1	7	7
47	R:R:I165	R:R:Y86	7.25	No	Yes	0	5	7
48	R:R:L87	R:R:Y314	5.86	No	Yes	1	7	9
49	R:R:L87	W:W:?1	4.07	No	Yes	1	7	0
50	R:R:L136	R:R:N89	5.49	No	No	0	8	9
51	R:R:C166	R:R:N89	9.45	No	No	0	7	9
52	R:R:N89	R:R:W170	5.65	No	Yes	0	9	9
53	R:R:L90	R:R:N310	4.12	No	Yes	0	9	9
54	R:R:L92	R:R:L96	4.15	No	No	0	6	7
55	R:R:L92	R:R:W170	6.83	No	Yes	0	6	9
56	R:R:D94	R:R:H306	6.3	No	Yes	0	9	9
57	R:R:D94	R:R:S307	5.89	No	No	0	9	8
58	R:R:F97	R:R:N129	15.71	No	No	0	6	8
59	R:R:F97	R:R:S307	7.93	No	No	0	6	8
60	R:R:T100	R:R:W104	3.64	No	Yes	2	7	6
61	R:R:T100	R:R:V122	11.11	No	No	2	7	5
62	R:R:L125	R:R:T100	4.42	No	No	0	4	7
63	R:R:I304	R:R:L101	4.28	No	No	0	7	8
64	R:R:I103	R:R:W112	3.52	No	Yes	0	6	9
65	R:R:S107	R:R:W104	4.94	No	Yes	0	5	6
66	R:R:V122	R:R:W104	6.13	No	Yes	2	5	6
67	R:R:K126	R:R:W104	6.96	No	Yes	0	6	6
68	R:R:S107	R:R:W112	4.94	No	Yes	0	5	9
69	R:R:E300	R:R:K108	4.05	No	No	0	5	5
70	R:R:N110	R:R:V109	7.39	No	No	0	4	4
71	R:R:F114	R:R:W112	15.03	Yes	Yes	2	6	9
72	R:R:L118	R:R:W112	4.56	No	Yes	2	6	9
73	R:R:C119	R:R:W112	3.92	No	Yes	2	9	9
74	R:R:V122	R:R:W112	4.9	No	Yes	2	5	9
75	R:R:C196	R:R:W112	11.75	No	Yes	2	9	9
76	R:R:F114	R:R:L118	3.65	Yes	No	2	6	6
77	R:R:R185	R:R:T116	3.88	No	No	0	4	3
78	R:R:T116	R:R:T186	4.71	No	No	0	3	4
79	R:R:F117	R:R:V121	7.87	No	No	0	1	5
80	R:R:C119	R:R:C196	5.46	No	No	2	9	9
81	R:R:R184	R:R:S123	9.22	Yes	No	0	5	5
82	R:R:L124	R:R:L174	4.15	No	No	0	6	5
83	R:R:L124	R:R:L181	5.54	No	No	0	6	5
84	R:R:K126	R:R:R184	6.19	No	Yes	0	6	5
85	R:R:E127	R:R:Y131	10.1	No	Yes	0	4	7
86	R:R:E127	R:R:V180	7.13	No	No	0	4	4
87	R:R:S173	R:R:V128	6.46	No	No	0	7	5
88	R:R:F130	R:R:Y131	5.16	Yes	Yes	0	7	7
89	R:R:F130	R:R:I134	5.02	Yes	No	0	7	8
90	R:R:F130	R:R:W264	16.04	Yes	No	0	7	8
91	R:R:F130	R:R:N268	6.04	Yes	No	0	7	8
92	R:R:L176	R:R:Y131	15.24	No	Yes	6	4	7
93	R:R:P215	R:R:Y131	6.95	No	Yes	6	5	7
94	R:R:G133	R:R:S132	3.71	No	No	0	9	6
95	R:R:S132	R:R:W170	3.71	No	Yes	0	6	9
96	R:R:S132	R:R:S173	4.89	No	No	0	6	7
97	R:R:I134	R:R:P223	5.08	No	Yes	0	8	9
98	R:R:F260	R:R:I134	7.54	Yes	No	0	9	8
99	R:R:I169	R:R:W135	4.7	No	No	0	6	6
100	R:R:L172	R:R:W135	6.83	No	No	0	4	6
101	R:R:P223	R:R:W135	20.27	Yes	No	0	9	6
102	R:R:F260	R:R:L137	8.53	Yes	No	0	9	8
103	R:R:I140	R:R:Y231	3.63	Yes	Yes	1	9	9
104	R:R:I140	R:R:I253	4.42	Yes	Yes	1	9	7
105	R:R:S141	R:R:Y231	13.99	No	Yes	0	9	9
106	R:R:D143	R:R:R144	5.96	No	Yes	0	8	9
107	R:R:D143	R:R:T154	7.23	No	No	0	8	5
108	R:R:A147	R:R:R144	4.15	No	Yes	0	8	9
109	R:R:M250	R:R:R144	7.44	No	Yes	0	5	9
110	R:R:R144	W:W:?1	9.29	Yes	Yes	1	9	0
111	R:R:V149	R:R:Y145	8.83	No	Yes	7	7	8
112	R:R:H150	R:R:Y145	10.89	No	Yes	7	6	8
113	R:R:C230	R:R:Y145	8.06	No	Yes	0	7	8
114	R:R:T234	R:R:Y145	3.75	No	Yes	0	8	8
115	R:R:L146	R:R:T154	4.42	No	No	0	5	5
116	R:R:I148	R:R:T234	6.08	No	No	0	8	8
117	R:R:I148	R:R:L238	4.28	No	No	0	8	8
118	R:R:I148	R:R:K246	10.18	No	No	0	8	7
119	R:R:H150	R:R:V149	6.92	No	No	7	6	7
120	R:R:T237	R:R:V149	9.52	No	No	0	5	7
121	R:R:R153	R:R:T156	6.47	No	No	0	5	2
122	R:R:L155	R:R:V162	4.47	No	Yes	0	4	7
123	R:R:I165	R:R:L155	4.28	No	No	0	5	4
124	R:R:K158	R:R:Y160	10.75	No	No	8	6	5
125	R:R:K158	R:R:L161	7.05	No	No	8	6	4
126	R:R:L161	R:R:Y160	16.41	No	No	8	4	5
127	R:R:F164	R:R:Y160	4.13	No	No	0	3	5
128	R:R:L176	R:R:P215	4.93	No	No	6	4	5
129	R:R:L211	R:R:P179	9.85	No	No	0	4	8
130	R:R:R184	R:R:V180	3.92	Yes	No	5	5	4
131	R:R:E198	R:R:V180	4.28	Yes	No	5	5	4
132	R:R:F183	R:R:L182	4.87	Yes	No	0	5	4
133	R:R:E198	R:R:F183	7	Yes	Yes	0	5	5
134	R:R:F183	R:R:R208	20.31	Yes	No	0	5	4
135	R:R:F183	R:R:L211	4.87	Yes	No	0	5	4
136	R:R:E198	R:R:R184	5.82	Yes	Yes	5	5	5
137	R:R:T186	R:R:Y188	4.99	No	No	0	4	1
138	R:R:V187	R:R:Y197	13.88	No	Yes	0	3	3
139	R:R:P194	R:R:Y188	5.56	No	No	0	5	1
140	R:R:A195	R:R:Y197	4	No	Yes	0	3	3
141	R:R:E198	R:R:R212	8.14	Yes	No	0	5	5
142	R:R:D199	R:R:R208	3.57	No	No	0	4	4
143	R:R:I213	R:R:M209	4.37	No	No	0	4	3
144	R:R:L271	R:R:R212	4.86	No	No	0	6	5
145	R:R:I213	R:R:Q216	4.12	No	No	0	4	5
146	R:R:I221	R:R:S217	6.19	No	No	0	4	4
147	R:R:F218	R:R:V222	3.93	No	No	0	4	5
148	R:R:G219	R:R:P223	4.06	No	Yes	0	5	9
149	R:R:F220	R:R:I221	3.77	No	No	0	8	4
150	R:R:F220	R:R:N268	8.46	No	No	0	8	8
151	R:R:P223	R:R:V222	3.53	Yes	No	0	9	5
152	R:R:L224	R:R:L228	4.15	No	No	0	7	4
153	R:R:F229	R:R:L225	3.65	No	No	0	4	3
154	R:R:M227	R:R:Y231	5.99	No	Yes	0	8	9
155	R:R:I253	R:R:Y231	3.63	Yes	Yes	1	7	9
156	R:R:F254	R:R:Y231	6.19	No	Yes	0	4	9
157	R:R:V257	R:R:Y231	10.09	No	Yes	0	7	9
158	R:R:F239	R:R:L235	6.09	No	No	0	5	4
159	R:R:F254	R:R:L235	9.74	No	No	0	4	4
160	R:R:K240	R:R:T237	4.5	No	No	0	5	5
161	R:R:H247	R:R:L238	6.43	No	No	0	5	8
162	R:R:R248	R:R:R251	13.86	No	No	0	7	5
163	R:R:E249	R:R:K320	6.75	No	No	1	7	6
164	R:R:E249	W:W:?1	10.91	No	Yes	1	7	0
165	R:R:I253	R:R:M250	5.83	Yes	No	0	7	5
166	R:R:F254	R:R:M250	7.46	No	No	0	4	5
167	R:R:I317	R:R:R251	3.76	Yes	No	0	6	5
168	R:R:G318	R:R:V252	3.68	No	No	0	7	7
169	R:R:I253	W:W:?1	4.2	Yes	Yes	1	7	0
170	R:R:N310	R:R:V256	5.91	Yes	No	1	9	8
171	R:R:V256	R:R:Y314	3.79	No	Yes	1	8	9
172	R:R:L258	R:R:L262	4.15	No	No	0	5	5
173	R:R:I259	R:R:L309	4.28	No	No	0	6	6
174	R:R:F260	R:R:W264	10.02	Yes	No	0	9	8
175	R:R:F260	R:R:H306	11.31	Yes	Yes	0	9	9
176	R:R:C263	R:R:H306	7.37	No	Yes	0	7	9
177	R:R:A303	R:R:W264	7.78	No	No	0	7	8
178	R:R:L265	R:R:L269	5.54	No	No	0	6	6
179	R:R:L271	R:R:Y267	4.69	No	Yes	0	6	7
180	R:R:L296	R:R:Y267	4.69	No	Yes	0	5	7
181	R:R:T299	R:R:Y267	7.49	No	Yes	0	6	7
182	R:R:E300	R:R:Y267	4.49	No	Yes	0	5	7
183	R:R:L296	R:R:V270	4.47	No	No	0	5	4
184	R:R:T299	R:R:V270	4.76	No	No	0	6	4
185	R:R:D274	R:R:I292	12.59	No	No	0	4	5
186	R:R:D274	R:R:L296	4.07	No	No	0	4	5
187	R:R:L276	R:R:T279	4.42	No	No	0	4	1
188	R:R:M277	R:R:R289	3.72	No	No	0	4	3
189	R:R:H291	R:R:R289	6.77	No	No	0	3	3
190	R:R:H306	R:R:N310	7.65	Yes	Yes	0	9	9
191	R:R:N310	R:R:Y314	8.14	Yes	Yes	1	9	9
192	R:R:F321	R:R:Y314	4.13	Yes	Yes	1	8	9
193	R:R:Y314	W:W:?1	4.82	Yes	Yes	1	9	0
194	R:R:Q319	R:R:R322	7.01	No	No	0	5	8
195	R:R:H323	R:R:Q319	3.71	No	No	0	4	5
196	R:R:K320	W:W:?1	30.68	No	Yes	1	6	0
197	R:R:F321	W:W:?1	4.3	Yes	Yes	1	8	0
198	R:R:L329	R:R:L334	8.3	No	No	0	6	1
199	R:R:H332	R:R:I331	9.28	No	No	4	3	2
200	R:R:Q216	R:R:R212	3.5	No	No	0	5	5
201	R:R:V252	W:W:?1	3.5	No	Yes	0	7	0
202	R:R:P266	R:R:T299	3.5	No	No	0	9	6
203	R:R:C230	R:R:S141	3.44	No	No	0	7	9
204	R:R:A98	R:R:S62	3.42	No	No	0	5	8
205	R:R:S76	R:R:V78	3.23	No	No	0	4	5
206	R:R:V162	R:R:V85	3.21	Yes	No	0	7	6
207	R:R:C308	R:R:L61	3.17	No	No	0	7	5
208	R:R:A91	R:R:N66	3.13	No	Yes	0	8	9
209	R:R:I335	R:R:S336	3.1	No	No	0	4	8
210	R:R:I304	R:R:V58	3.07	No	No	0	7	7
211	R:R:I328	R:R:V72	3.07	No	Yes	0	5	7
212	R:R:I317	R:R:V252	3.07	Yes	No	0	6	7
213	R:R:L305	R:R:V58	2.98	No	No	0	5	7
214	R:R:L325	R:R:V72	2.98	No	Yes	0	6	7
215	R:R:L124	R:R:V128	2.98	No	No	0	6	5
216	R:R:N191	R:R:S190	2.98	No	No	0	2	2
217	R:R:L261	R:R:V257	2.98	No	No	0	6	7
218	R:R:L146	R:R:T152	2.95	No	No	0	5	5
219	R:R:I259	R:R:I313	2.94	No	No	0	6	7
220	R:R:I313	R:R:I317	2.94	No	Yes	9	7	6
221	R:R:L88	R:R:M70	2.83	No	No	0	5	6
222	R:R:L92	R:R:M70	2.83	No	No	0	6	6
223	R:R:L57	R:R:L61	2.77	No	No	0	5	5
224	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
225	R:R:L155	R:R:L161	2.77	No	No	0	4	4
226	R:R:L95	R:R:N66	2.75	No	Yes	0	7	9
227	R:R:L272	R:R:Q216	2.66	No	No	0	5	5
228	R:R:F50	R:R:V51	2.62	No	No	0	5	5
229	R:R:A93	R:R:W170	2.59	No	Yes	0	8	9
230	R:R:F114	R:R:I113	2.51	Yes	No	0	6	3
231	R:R:I292	R:R:R289	2.51	No	No	0	5	3
232	R:R:K240	R:R:R236	2.48	No	No	0	5	4
233	R:R:F117	R:R:L118	2.44	No	No	0	1	6
234	R:R:F220	R:R:L265	2.44	No	No	0	8	6
235	R:R:F316	R:R:L312	2.44	No	No	0	6	6
236	R:R:T186	R:R:W112	2.43	No	Yes	0	4	9
237	R:R:L210	R:R:W207	2.28	No	No	0	2	3
238	R:R:F233	R:R:Y145	2.06	No	Yes	0	4	8
239	R:R:R184	R:R:Y197	2.06	Yes	Yes	0	5	3
240	R:R:G111	R:R:P194	2.03	No	No	0	4	5
241	R:R:A138	R:R:P223	1.87	No	Yes	0	7	9
242	R:R:G111	R:R:S193	1.86	No	No	0	4	3
243	R:R:G324	R:R:V72	1.84	No	Yes	0	5	7
244	R:R:G79	R:R:V78	1.84	No	No	0	6	5
245	R:R:G244	R:R:K246	1.74	No	No	0	4	7
246	R:R:G324	R:R:K327	1.74	No	No	0	5	4
247	R:R:G65	R:R:L64	1.71	No	No	0	7	4
248	R:R:G171	R:R:L174	1.71	No	No	0	4	5
249	R:R:A105	R:R:V52	1.7	No	No	0	7	5
250	R:R:G111	R:R:N110	1.7	No	No	0	4	4
251	R:R:A177	R:R:V128	1.7	No	No	0	7	5
252	R:R:L101	R:R:P102	1.64	No	No	0	8	9
253	R:R:L178	R:R:P179	1.64	No	No	0	3	8
254	R:R:L214	R:R:P215	1.64	No	No	0	3	5
255	R:R:C230	R:R:I226	1.64	No	No	0	7	6
256	R:R:L302	R:R:P266	1.64	No	No	0	7	9
257	R:R:A255	R:R:I313	1.62	No	No	9	5	7
258	R:R:A255	R:R:I317	1.62	No	Yes	9	5	6
259	R:R:A273	R:R:I292	1.62	No	No	0	5	5
260	R:R:G333	R:R:H332	1.59	No	No	0	3	3
261	R:R:I226	R:R:V142	1.54	No	No	0	6	6
262	R:R:L63	R:R:S67	1.5	No	No	0	5	3
263	R:R:L95	R:R:S67	1.5	No	No	0	7	3
264	R:R:L71	R:R:V72	1.49	No	Yes	0	3	7
265	R:R:I53	R:R:I54	1.47	No	No	0	5	5
266	R:R:I221	R:R:L225	1.43	No	No	0	4	3
267	R:R:G115	R:R:W112	1.41	No	Yes	0	8	9
268	R:R:K120	R:R:L181	1.41	No	No	0	7	5
269	R:R:A315	R:R:F321	1.39	No	Yes	0	7	8
270	R:R:L312	R:R:L61	1.38	No	No	0	6	5
271	R:R:L96	R:R:L99	1.38	No	No	0	7	4
272	R:R:L224	R:R:L261	1.38	No	No	0	7	6
273	R:R:L272	R:R:L276	1.38	No	No	0	5	4
274	R:R:L325	R:R:L329	1.38	No	No	0	6	6
275	R:R:L326	R:R:L329	1.38	No	No	0	4	6
276	R:R:S189	R:R:Y197	1.27	No	Yes	0	1	3
277	R:R:H247	R:R:Q245	1.24	No	No	0	5	4
278	R:R:D297	R:R:R294	1.19	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y55	6.1975	4	3	7
2	R:R:N66	5.6675	4	0	9
3	R:R:V72	3.45	5	0	7
4	R:R:V82	6	4	1	7
5	R:R:D84	9.9625	4	1	8
6	R:R:Y86	5.64333	6	1	7
7	R:R:W104	5.4175	4	2	6
8	R:R:W112	5.82889	9	2	9
9	R:R:F114	5.99	4	2	6
10	R:R:F130	8.065	4	0	7
11	R:R:Y131	9.3625	4	6	7
12	R:R:I140	4.7425	4	1	9
13	R:R:R144	6.402	5	1	9
14	R:R:Y145	6.718	5	7	8
15	R:R:V162	4.07	4	1	7
16	R:R:W170	4.695	4	0	9
17	R:R:F183	9.2625	4	0	5
18	R:R:R184	5.442	5	5	5
19	R:R:Y197	5.3025	4	0	3
20	R:R:E198	6.31	4	5	5
21	R:R:P223	6.962	5	0	9
22	R:R:Y231	7.25333	6	1	9
23	R:R:I253	4.52	4	1	7
24	R:R:F260	9.35	4	0	9
25	R:R:Y267	5.34	4	0	7
26	R:R:H306	8.1575	4	0	9
27	R:R:N310	6.455	4	1	9
28	R:R:Y314	5.29833	6	1	9
29	R:R:I317	2.8475	4	9	6
30	R:R:F321	4.586	5	1	8
31	W:W:?1	9.8175	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I304	R:R:Y55	13.7829	7.25	No	Yes	0	7	7
2	R:R:F59	R:R:P102	19.9074	8.67	No	No	0	7	9
3	R:R:L101	R:R:P102	19.2245	1.64	No	No	0	8	9
4	R:R:I304	R:R:L101	18.5718	4.28	No	No	0	7	8
5	R:R:F59	R:R:L63	21.273	4.87	No	No	0	7	5
6	R:R:L63	R:R:S67	22.2687	1.5	No	No	0	5	3
7	R:R:L95	R:R:S67	23.4869	1.5	No	No	0	7	3
8	R:R:L95	R:R:N66	24.7624	2.75	No	Yes	0	7	9
9	R:R:N66	R:R:P311	25.0301	11.4	Yes	No	0	9	9
10	R:R:P311	R:R:V69	25.4271	3.53	No	No	0	9	8
11	R:R:F321	R:R:V69	13.801	5.24	Yes	No	1	8	8
12	R:R:F321	R:R:V72	15.8886	7.87	Yes	Yes	0	8	7
13	R:R:V69	R:R:Y314	12.9106	5.05	No	Yes	1	8	9
14	R:R:Y314	W:W:?1	93.1206	4.82	Yes	Yes	1	9	0
15	R:R:I73	W:W:?1	19.2366	5.03	No	Yes	0	6	0
16	R:R:F321	W:W:?1	17.913	4.3	Yes	Yes	1	8	0
17	R:R:I73	R:R:L88	18.2198	11.42	No	No	0	6	5
18	R:R:R144	W:W:?1	18.4334	9.29	Yes	Yes	1	9	0
19	R:R:D143	R:R:R144	13.8972	5.96	No	Yes	0	8	9
20	R:R:T83	W:W:?1	18.7793	11.27	No	Yes	1	7	0
21	R:R:I140	R:R:T83	18.653	6.08	Yes	No	1	9	7
22	R:R:I140	R:R:Y86	37.5105	4.84	Yes	Yes	1	9	7
23	R:R:I253	W:W:?1	49.1126	4.2	Yes	Yes	1	7	0
24	R:R:I140	R:R:I253	18.0063	4.42	Yes	Yes	1	9	7
25	R:R:V162	R:R:Y86	14.3184	3.79	Yes	Yes	1	7	7
26	R:R:I165	R:R:Y86	12.0623	7.25	No	Yes	0	5	7
27	R:R:L88	R:R:M70	15.9758	2.83	No	No	0	5	6
28	R:R:L92	R:R:M70	14.9801	2.83	No	No	0	6	6
29	R:R:L92	R:R:W170	12.2819	6.83	No	Yes	0	6	9
30	R:R:D94	R:R:H306	11.7736	6.3	No	Yes	0	9	9
31	R:R:H306	R:R:N310	93.8365	7.65	Yes	Yes	0	9	9
32	R:R:L271	R:R:Y267	22.8282	4.69	No	Yes	0	6	7
33	R:R:L271	R:R:R212	23.8238	4.86	No	No	0	6	5
34	R:R:E198	R:R:R212	31.4132	8.14	Yes	No	0	5	5
35	R:R:K126	R:R:R184	56.8343	6.19	No	Yes	0	6	5
36	R:R:K126	R:R:W104	55.7484	6.96	No	Yes	0	6	6
37	R:R:V122	R:R:W104	26.0588	6.13	No	Yes	2	5	6
38	R:R:S107	R:R:W112	25.006	4.94	No	Yes	0	5	9
39	R:R:S107	R:R:W104	26.2062	4.94	No	Yes	0	5	6
40	R:R:V122	R:R:W112	25.1203	4.9	No	Yes	2	5	9
41	R:R:T186	R:R:W112	22.9816	2.43	No	Yes	0	4	9
42	R:R:T186	R:R:Y188	15.3742	4.99	No	No	0	4	1
43	R:R:P194	R:R:Y188	12.8264	5.56	No	No	0	5	1
44	R:R:G111	R:R:P194	10.2725	2.03	No	No	0	4	5
45	R:R:S132	R:R:W170	11.6081	3.71	No	Yes	0	6	9
46	R:R:E127	R:R:V180	87.4925	7.13	No	No	0	4	4
47	R:R:E198	R:R:V180	31.726	4.28	Yes	No	5	5	4
48	R:R:E127	R:R:Y131	88.2926	10.1	No	Yes	0	4	7
49	R:R:F130	R:R:Y131	91.3368	5.16	Yes	Yes	0	7	7
50	R:R:F130	R:R:I134	50.0993	5.02	Yes	No	0	7	8
51	R:R:F130	R:R:W264	47.9004	16.04	Yes	No	0	7	8
52	R:R:F130	R:R:N268	10.8802	6.04	Yes	No	0	7	8
53	R:R:F260	R:R:I134	51.9943	7.54	Yes	No	0	9	8
54	R:R:F260	R:R:W264	48.3215	10.02	Yes	No	0	9	8
55	R:R:F260	R:R:H306	100	11.31	Yes	Yes	0	9	9
56	R:R:I253	R:R:Y231	27.1087	3.63	Yes	Yes	1	7	9
57	R:R:S141	R:R:Y231	21.655	13.99	No	Yes	0	9	9
58	R:R:C230	R:R:S141	20.5029	3.44	No	No	0	7	9
59	R:R:C230	R:R:Y145	17.0106	8.06	No	Yes	0	7	8
60	R:R:L155	R:R:V162	15.3441	4.47	No	Yes	0	4	7
61	R:R:I165	R:R:L155	10.1853	4.28	No	No	0	5	4
62	R:R:L155	R:R:L161	20.5962	2.77	No	No	0	4	4
63	R:R:L161	R:R:Y160	10.3026	16.41	No	No	8	4	5
64	R:R:V252	W:W:?1	11.2141	3.5	No	Yes	0	7	0
65	R:R:L296	R:R:Y267	10.5192	4.69	No	Yes	0	5	7
66	R:R:R184	R:R:V180	55.1197	3.92	Yes	No	5	5	4
67	R:R:F321	R:R:Y314	10.3387	4.13	Yes	Yes	1	8	9
68	R:R:N310	R:R:Y314	92.537	8.14	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V69	R:R:Y314	5.05	1	No	Yes	8	9	2	1
R:R:F321	R:R:V69	5.24	1	Yes	No	8	8	1	2
R:R:F321	R:R:V72	7.87	1	Yes	Yes	8	7	1	2
R:R:I73	R:R:L88	11.42	0	No	No	6	5	1	2
R:R:I73	W:W:?1	5.03	0	No	Yes	6	0	1	0
R:R:D84	R:R:R80	3.57	1	Yes	No	8	7	1	2
R:R:D84	R:R:S81	8.83	1	Yes	No	8	7	1	1
R:R:S81	W:W:?1	10.59	1	No	Yes	7	0	1	0
R:R:I140	R:R:T83	6.08	1	Yes	No	9	7	2	1
R:R:R144	R:R:T83	5.17	1	Yes	No	9	7	1	1
R:R:T83	W:W:?1	11.27	1	No	Yes	7	0	1	0
R:R:D84	R:R:K320	8.3	1	Yes	No	8	6	1	1
R:R:D84	W:W:?1	19.15	1	Yes	Yes	8	0	1	0
R:R:L87	R:R:Y314	5.86	1	No	Yes	7	9	1	1
R:R:L87	W:W:?1	4.07	1	No	Yes	7	0	1	0
R:R:I140	R:R:Y231	3.63	1	Yes	Yes	9	9	2	2
R:R:I140	R:R:I253	4.42	1	Yes	Yes	9	7	2	1
R:R:D143	R:R:R144	5.96	0	No	Yes	8	9	2	1
R:R:A147	R:R:R144	4.15	0	No	Yes	8	9	2	1
R:R:M250	R:R:R144	7.44	0	No	Yes	5	9	2	1
R:R:R144	W:W:?1	9.29	1	Yes	Yes	9	0	1	0
R:R:I253	R:R:Y231	3.63	1	Yes	Yes	7	9	1	2
R:R:E249	R:R:K320	6.75	1	No	No	7	6	1	1
R:R:E249	W:W:?1	10.91	1	No	Yes	7	0	1	0
R:R:I253	R:R:M250	5.83	1	Yes	No	7	5	1	2
R:R:G318	R:R:V252	3.68	0	No	No	7	7	2	1
R:R:I253	W:W:?1	4.2	1	Yes	Yes	7	0	1	0
R:R:N310	R:R:V256	5.91	1	Yes	No	9	8	2	2
R:R:V256	R:R:Y314	3.79	1	No	Yes	8	9	2	1
R:R:N310	R:R:Y314	8.14	1	Yes	Yes	9	9	2	1
R:R:F321	R:R:Y314	4.13	1	Yes	Yes	8	9	1	1
R:R:Y314	W:W:?1	4.82	1	Yes	Yes	9	0	1	0
R:R:K320	W:W:?1	30.68	1	No	Yes	6	0	1	0
R:R:F321	W:W:?1	4.3	1	Yes	Yes	8	0	1	0
R:R:V252	W:W:?1	3.5	0	No	Yes	7	0	1	0
R:R:I317	R:R:V252	3.07	9	Yes	No	6	7	2	1
R:R:A315	R:R:F321	1.39	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
73.33	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
53.85	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
53.33	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
37.50	Single	5X7D	PubChem 129318963	5X7D-β₂-S-Carazolol-PubChem 129318963
31.82	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
27.78	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
21.43	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
21.05	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
19.35	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody
19.05	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67	Single	8PJK	t7m	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
15.00	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
14.29	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/β1/γ2
13.04	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
13.04	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
9.52	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.70	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.00	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
6.67	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
5.88	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.88	Single	8PKM	t7m	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
5.56	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.26	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
5.26	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
5.26	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
5.00	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
5.00	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
5.00	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
5.00	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
5.00	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
5.00	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
5.00	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.00	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
5.00	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
4.76	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
4.76	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.76	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.76	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.55	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
4.55	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
4.35	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
4.00	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
3.85	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2

PDB Summary
PDB	6LFL
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	PubChem 153466996
Protein Partners	-
PDB Resolution	3.2
Date	2020-09-02
D.O.I.	10.1038/s41586-020-2492-5

Net Summary
I_min	3.52
Number of Linked Nodes	257
Number of Links	278
Number of Hubs	31
Number of Links mediated by Hubs	127
Number of Communities	9
Number of Nodes involved in Communities	48
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	59669
Length Of Smallest Path	3
Average Path Length	15.6488
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	6.3365
Maximum Path Strength	20.975
Minimum Path Correlation	0.7
Average Path Correlation	0.925126
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	42.6159
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.9731
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• UDP-glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity • glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity • transferase activity • glucosyltransferase activity • hexosyltransferase activity • catalytic activity • UDP-glucosyltransferase activity • G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • protein binding • binding • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • developmental process • multicellular organismal process • head development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • midbrain development • anatomical structure development • system development • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • head development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • midbrain development • anatomical structure development • system development • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • response to stimulus • immune response • immune system process • defense response • response to stress • inflammatory response • acute inflammatory response to antigenic stimulus • acute inflammatory response • inflammatory response to antigenic stimulus • regulation of cellular process • homeostatic process • leukocyte apoptotic process • negative regulation of biological process • regulation of programmed cell death • regulation of neutrophil apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of neutrophil apoptotic process • negative regulation of cellular process • regulation of immune system process • myeloid cell homeostasis • regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of biological process • negative regulation of programmed cell death • regulation of apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • negative regulation of apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • homeostasis of number of cells • apoptotic process • programmed cell death • regulation of myeloid cell apoptotic process • neutrophil activation • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • cellular response to stimulus • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • taxis • granulocyte chemotaxis • response to chemical • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of response to stimulus • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of vascular permeability • system process • circulatory system process • positive regulation of vascular permeability • vascular process in circulatory system • blood circulation • cellular defense response • epithelium development • kidney epithelium development • metanephric tubule morphogenesis • morphogenesis of an epithelium • metanephric epithelium development • tissue development • renal system development • tissue morphogenesis • metanephros development • metanephric tubule development • epithelial tube morphogenesis • kidney development • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to interleukin-8 • response to interleukin-8 • cellular response to cytokine stimulus • interleukin-8-mediated signaling pathway • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • mast cell granule
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • mast cell granule • organelle • cytoplasm • lysosome • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • organelle membrane • secretory granule membrane
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Type B glycosyltransferase-like
SCOP2	Family Identifier	• G protein-coupled receptor-like • Type B glycosyltransferase-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	EBX
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	EBX
Name	4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide
Synonyms
Identifier
Formula	C22 H26 N4 O5
Molecular Weight	426.466
SMILES
PubChem	153466996
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	1
Total Bonds	59
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>6LFL_Chain_R I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I W L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A G Q K H R E M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T R N H I D R A L D A T E I L A I L H S C L N P L I Y A F I G Q K F R H G L L K I L A I H G L I S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	To be published
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	To be published
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	To be published
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	To be published
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	To be published
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	To be published
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	To be published
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	To be published
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	To be published
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	To be published
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	To be published
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	To be published
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	To be published
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	To be published
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	To be published
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	To be published
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	To be published
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	To be published
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	10.1038/s41586-020-2492-5

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LFL.zip

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