Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:E9 5.2975400
2L:L:L15 4.335460
3L:L:F32 7.412530
4L:L:K40 2.385400
5L:L:E42 8.946530
6L:L:V43 4.945470
7L:L:V53 3.105400
8L:L:L62 3.44400
9R:R:V51 3.156545
10R:R:Y55 5.20333647
11R:R:I73 5.1025406
12R:R:Y86 5.426517
13R:R:L88 4.915405
14R:R:L90 4.0625419
15R:R:F97 5.85406
16R:R:K108 5.43445
17R:R:W112 4.91444929
18R:R:F114 3.505426
19R:R:Y145 6.465658
20R:R:V149 6.5725457
21R:R:H150 7.7225456
22R:R:R159 4.7025413
23R:R:W170 5.414509
24R:R:V192 5.67405
25R:R:M200 4.7275405
26R:R:R208 12.515404
27R:R:R212 5.45405
28R:R:F220 6.2275408
29R:R:Y231 7.256519
30R:R:T234 3.06408
31R:R:W264 6.6565108
32R:R:L265 4.5025406
33R:R:R278 8.14404
34R:R:R288 5.464111
35R:R:S307 3.57488
36R:R:C308 2.4475487
37R:R:N310 5.5675419
38R:R:I313 5.545417
39R:R:Y314 5.15143719
40R:R:F321 4.71167698
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:L10 R:R:V192 41.81365.96NoYes005
2L:L:L10 R:R:Y197 42.46899.38NoNo003
3R:R:R208 R:R:Y197 47.574919.55YesNo043
4R:R:E198 R:R:R208 49.595617.45NoYes054
5R:R:E198 R:R:R184 49.038810.47NoNo055
6R:R:R184 R:R:S123 48.008610.54NoNo055
7R:R:C196 R:R:S123 47.39113.44NoNo095
8R:R:C196 R:R:W112 46.02759.14NoYes299
9L:L:E9 R:R:R208 81.634810.47YesYes004
10L:L:E9 R:R:R212 86.21433.49YesYes005
11L:L:E9 R:R:R278 19.13795.82YesYes004
12L:L:R11 R:R:R278 28.435117.06NoYes004
13L:L:R11 R:R:R289 25.79520.26NoNo003
14L:L:A59 L:L:F61 10.09452.77NoNo000
15L:L:F61 L:L:L62 10.91273.65NoYes000
16L:L:L55 L:L:L62 15.7444.15NoYes000
17L:L:L55 L:L:V53 17.31222.98NoYes000
18L:L:A45 L:L:V53 24.98821.7NoYes000
19L:L:A45 L:L:I26 25.73444.87NoNo000
20L:L:G27 L:L:I26 26.47681.76NoNo000
21L:L:G27 L:L:S46 27.21541.86NoNo000
22L:L:Q52 L:L:S46 28.68134.33NoNo000
23L:L:Q52 L:L:V44 30.85174.3NoNo000
24L:L:F32 L:L:V44 31.26465.24YesNo300
25L:L:F32 L:L:Q37 37.10913.51YesNo000
26L:L:Q37 R:R:S189 37.80235.78NoNo001
27R:R:S189 R:R:V192 38.48034.85NoYes015
28L:L:L15 R:R:R289 21.74586.07YesNo603
29L:L:L15 R:R:E284 17.82355.3YesNo003
30R:R:W104 R:R:W112 34.24753.75NoYes069
31R:R:K108 R:R:W104 18.15.8YesNo056
32R:R:K108 R:R:V51 13.42213.04YesYes455
33R:R:K126 R:R:W104 15.759213.92NoNo066
34R:R:F97 R:R:K126 13.40699.93YesNo066
35R:R:Q216 R:R:R212 1003.5NoYes055
36R:R:N268 R:R:Q216 66.885110.56NoNo085
37R:R:N268 R:R:Y267 32.84793.49NoNo087
38R:R:W264 R:R:Y267 65.34916.75YesNo087
39R:R:H306 R:R:W264 65.32838.46NoYes098
40R:R:H306 R:R:N310 64.66923.83NoYes099
41R:R:D94 R:R:N310 20.79888.08NoYes099
42R:R:D94 R:R:S307 10.11164.42NoYes098
43R:R:L271 R:R:Q216 33.38575.32NoNo065
44R:R:L271 R:R:Y267 33.139512.89NoNo067
45R:R:D94 R:R:N66 10.111612.12NoNo099
46R:R:F220 R:R:N268 34.177415.71YesNo088
47R:R:F220 R:R:F260 32.6134.29YesNo089
48R:R:F260 R:R:M227 32.26839.95NoNo098
49R:R:M227 R:R:Y231 31.56384.79NoYes189
50R:R:R144 R:R:Y231 23.07349.26NoYes199
51R:R:I140 R:R:R144 19.93526.26NoNo199
52R:R:I140 R:R:Y86 55.48196.04NoYes197
53R:R:V162 R:R:Y86 40.01258.83NoYes077
54R:R:V162 R:R:V85 37.71336.41NoNo076
55R:R:N89 R:R:V85 36.4164.43NoNo096
56R:R:L88 R:R:N89 33.814.12YesNo059
57R:R:I73 R:R:L88 28.55258.56YesYes065
58R:R:N310 R:R:Y314 48.02373.49YesYes199
59R:R:I140 R:R:Y314 36.76074.84NoYes199
60R:R:F321 R:R:I73 23.23445.02YesYes086
61R:R:F97 R:R:N129 11.66464.83YesNo068
62R:R:L96 R:R:N129 10.85596.87NoNo078
63R:R:I253 R:R:Y231 17.020512.09NoYes079
64R:R:I253 R:R:T234 10.68733.04NoYes078
65R:R:D274 R:R:R212 12.3888.34NoYes045
66R:R:D274 R:R:R278 11.90325.96NoYes044
67R:R:E284 R:R:M277 15.12286.77NoNo034
68R:R:M277 R:R:R288 11.04342.48NoYes041
69R:R:F321 R:R:K320 12.41264.96YesNo086
70R:R:G324 R:R:K320 11.04341.74NoNo056
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:V6 R:R:S43 3.23 0 No No 0 5 0 1
L:L:L7 R:R:P41 6.57 0 No No 0 4 0 1
L:L:L7 R:R:V192 5.96 0 No Yes 0 5 0 1
L:L:E9 R:R:R208 10.47 0 Yes Yes 0 4 0 1
L:L:E9 R:R:R212 3.49 0 Yes Yes 0 5 0 1
L:L:E9 R:R:R278 5.82 0 Yes Yes 0 4 0 1
L:L:L10 R:R:V192 5.96 0 No Yes 0 5 0 1
L:L:L10 R:R:Y197 9.38 0 No No 0 3 0 1
L:L:R11 R:R:R278 17.06 0 No Yes 0 4 0 1
L:L:R11 R:R:R289 20.26 0 No No 0 3 0 1
L:L:R11 R:R:D293 10.72 0 No No 0 4 0 1
L:L:L15 R:R:C39 4.76 6 Yes No 0 8 0 1
L:L:L15 R:R:E284 5.3 6 Yes No 0 3 0 1
L:L:L15 R:R:R289 6.07 6 Yes No 0 3 0 1
L:L:R16 R:R:D35 13.1 0 No No 0 6 0 1
L:L:T18 R:R:A36 3.36 0 No No 0 5 0 1
L:L:A34 R:R:N202 6.25 0 No No 0 2 0 1
L:L:G35 R:R:N202 3.39 0 No No 0 2 0 1
L:L:P36 R:R:V187 7.07 0 No No 0 3 0 1
L:L:P36 R:R:D199 4.83 0 No No 0 4 0 1
L:L:Q37 R:R:S189 5.78 0 No No 0 1 0 1
L:L:Q52 R:R:P38 6.32 0 No No 0 7 0 1
R:R:C286 R:R:C39 7.28 0 No No 6 8 2 1
R:R:C39 R:R:R289 8.36 6 No No 8 3 1 1
R:R:D199 R:R:R185 22.63 0 No No 4 4 1 2
R:R:V187 R:R:Y197 5.05 0 No No 3 3 1 1
R:R:S189 R:R:V192 4.85 0 No Yes 1 5 1 1
R:R:N191 R:R:V192 5.91 0 No Yes 2 5 2 1
R:R:P194 R:R:S193 3.56 0 No No 5 3 2 1
R:R:R208 R:R:Y197 19.55 0 Yes No 4 3 1 1
R:R:E198 R:R:R208 17.45 0 No Yes 5 4 2 1
R:R:M209 R:R:T275 4.52 0 No No 3 4 2 2
R:R:M209 R:R:R278 3.72 0 No Yes 3 4 2 1
R:R:Q216 R:R:R212 3.5 0 No Yes 5 5 2 1
R:R:D274 R:R:R212 8.34 0 No Yes 4 5 2 1
R:R:R212 R:R:T275 6.47 0 Yes No 5 4 1 2
R:R:D274 R:R:R278 5.96 0 No Yes 4 4 2 1
R:R:E284 R:R:M277 6.77 0 No No 3 4 1 2
R:R:E284 R:R:Q280 11.47 0 No No 3 2 1 2
L:L:Q30 R:R:S190 2.89 0 No No 0 2 0 1
R:R:R208 R:R:T204 2.59 0 Yes No 4 3 1 2
R:R:A37 R:R:P38 1.87 0 No No 7 7 2 1
R:R:G111 R:R:S193 1.86 0 No No 4 3 2 1
L:L:V6 R:R:S193 1.62 0 No No 0 3 0 1
R:R:E40 R:R:P41 1.57 0 No No 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XXX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.04
Number of Linked Nodes 335
Number of Links 361
Number of Hubs 40
Number of Links mediated by Hubs 160
Number of Communities 11
Number of Nodes involved in Communities 57
Number of Links involved in Communities 69
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 81574
Length Of Smallest Path 3
Average Path Length 19.3035
Length of Longest Path 46
Minimum Path Strength 1.325
Average Path Strength 6.65936
Maximum Path Strength 18.66
Minimum Path Correlation 0.7
Average Path Correlation 0.948685
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 52.2048
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.9222
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25025
Sequence
>8XXX_nogp_Chain_R
LLDAAPCEP ESLEINKYF VVIIYALVF LLSLLGNSL VMLVILYSR 
VGRSVTDVY LLNLALADL LFALTLPIW AASKVNGWI FGTFLCKVV 
SLLKEVNFY SGILLLACI SVDRYLAIV HATRTLTQK RYLVKFICL 
SIWGLSLLL ALPVLLFRR TVYSSNVSP ACYEDMGNN TANWRMLLR 
ILPQSFGFI VPLLIMLFC YGFTLRTLF KAHMGQKHR AMRVIFAVV 
LIFLLCWLP YNLVLLADT LMRTQVIQE TCERRNHID RALDATEIL 
GILHSCLNP LIYAFIGQK FRHGLLKIL A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LFLAProteinChemokineCXCR2Homo sapiens-PubChem 153466996-3.22020-09-02doi.org/10.1038/s41586-020-2492-5
6LFMAProteinChemokineCXCR2Homo sapiensInterleukin-8-Gi1/β1/γ23.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFM (No Gprot) AProteinChemokineCXCR2Homo sapiensInterleukin-8-3.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFOAProteinChemokineCXCR2Homo sapiensInterleukin-8-Gi1/β1/γ23.42020-09-02doi.org/10.1038/s41586-020-2492-5
6LFO (No Gprot) AProteinChemokineCXCR2Homo sapiensInterleukin-8-3.42020-09-02doi.org/10.1038/s41586-020-2492-5
8XVUAProteinChemokineCXCR2Homo sapiensCXCL2--3.092025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWAAProteinChemokineCXCR2Homo sapiensCXCL1--3.482025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWFAProteinChemokineCXCR2Homo sapiensCXCL3--3.652025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWMAProteinChemokineCXCR2Homo sapiensCXCL6--3.712025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWNAProteinChemokineCXCR2Homo sapiensCXCL8--3.292025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWSAProteinChemokineCXCR2Homo sapiensCXCL5--3.062025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWVAProteinChemokineCXCR2Homo sapiensCXCL1-Go/β1/γ23.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWV (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL1-3.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3AProteinChemokineCXCR2Homo sapiensCXCL3-Go/β1/γ23.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL3-3.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6AProteinChemokineCXCR2Homo sapiensCXCL8-Go/β1/γ22.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL8-2.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7AProteinChemokineCXCR2Homo sapiensCXCL5-Go/β1/γ23.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL5-3.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXHAProteinChemokineCXCR2Homo sapiensCXCL2-Go/β1/γ22.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXH (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL2-2.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXRAProteinChemokineCXCR2Homo sapiens--Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXR (No Gprot) AProteinChemokineCXCR2Homo sapiens--3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXXAProteinChemokineCXCR2Homo sapiensCXCL6-Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXX (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL6-3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XXX_nogp.zip



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