psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V43	R:R:S43	3.23	No	No	0	3	5
2	L:L:L44	R:R:P41	6.57	No	No	0	3	4
3	L:L:L44	R:R:V192	5.96	No	Yes	0	3	5
4	L:L:E46	R:R:R208	10.47	Yes	Yes	0	7	4
5	L:L:E46	R:R:R212	3.49	Yes	Yes	0	7	5
6	L:L:E46	R:R:R278	5.82	Yes	Yes	0	7	4
7	L:L:L47	R:R:V192	5.96	No	Yes	0	8	5
8	L:L:L47	R:R:Y197	9.38	No	No	0	8	3
9	L:L:R48	R:R:R278	17.06	No	Yes	0	9	4
10	L:L:R48	R:R:R289	20.26	No	No	0	9	3
11	L:L:R48	R:R:D293	10.72	No	No	0	9	4
12	L:L:C49	L:L:C75	7.28	No	No	0	9	9
13	L:L:E79	L:L:T50	5.64	Yes	No	0	9	6
14	L:L:C51	L:L:E79	12.15	No	Yes	3	9	9
15	L:L:C51	L:L:C91	7.28	No	No	3	9	9
16	L:L:L52	R:R:C39	4.76	Yes	No	6	7	8
17	L:L:L52	R:R:E284	5.3	Yes	No	0	7	3
18	L:L:L52	R:R:R289	6.07	Yes	No	6	7	3
19	L:L:R53	R:R:D35	13.1	No	No	0	3	6
20	L:L:K77	L:L:V54	3.04	Yes	No	0	4	7
21	L:L:T55	L:L:V90	4.76	No	Yes	0	6	5
22	L:L:T55	R:R:A36	3.36	No	No	0	6	5
23	L:L:N59	L:L:P60	6.52	No	No	0	5	5
24	L:L:K61	L:L:N59	6.99	No	No	0	5	5
25	L:L:N59	L:L:T62	11.7	No	No	0	5	4
26	L:L:A82	L:L:I63	4.87	No	No	0	9	8
27	L:L:K65	L:L:S83	3.06	No	No	0	5	8
28	L:L:L66	L:L:V80	5.96	No	Yes	0	7	8
29	L:L:F69	L:L:Q67	11.71	Yes	No	0	4	6
30	L:L:V68	L:L:V80	3.21	No	Yes	7	7	8
31	L:L:I103	L:L:V68	3.07	No	No	7	5	7
32	L:L:F69	L:L:Q74	3.51	Yes	No	0	4	8
33	L:L:E79	L:L:F69	15.16	Yes	Yes	3	9	4
34	L:L:F69	L:L:V81	5.24	Yes	No	3	4	9
35	L:L:A71	R:R:N202	6.25	No	No	0	6	2
36	L:L:G72	L:L:P73	4.06	No	No	0	8	7
37	L:L:G72	R:R:N202	3.39	No	No	0	8	2
38	L:L:P73	R:R:V187	7.07	No	No	0	7	3
39	L:L:P73	R:R:D199	4.83	No	No	0	7	4
40	L:L:Q74	R:R:S189	5.78	No	No	0	8	1
41	L:L:K77	L:L:P94	3.35	Yes	No	0	4	8
42	L:L:P94	L:L:V78	3.53	No	No	0	8	6
43	L:L:E79	L:L:V81	5.7	Yes	No	3	9	9
44	L:L:C91	L:L:E79	6.08	No	Yes	3	9	9
45	L:L:L99	L:L:V80	4.47	Yes	Yes	0	7	8
46	L:L:I103	L:L:V80	6.14	No	Yes	7	5	8
47	L:L:Q89	L:L:V81	4.3	No	No	0	4	9
48	L:L:Q89	L:L:S83	4.33	No	No	0	4	8
49	L:L:K88	L:L:L84	4.23	No	No	0	2	8
50	L:L:Q89	R:R:P38	6.32	No	No	0	4	7
51	L:L:L92	L:L:L99	4.15	No	Yes	0	9	7
52	L:L:D93	L:L:P94	8.05	No	No	0	7	8
53	L:L:D93	L:L:E95	9.09	No	No	0	7	3
54	L:L:A96	L:L:D93	4.63	No	No	0	8	7
55	L:L:F98	L:L:L99	3.65	No	Yes	0	2	7
56	R:R:C286	R:R:C39	7.28	No	No	0	6	8
57	R:R:C39	R:R:R289	8.36	No	No	6	8	3
58	R:R:E42	R:R:N290	6.57	No	No	0	4	3
59	R:R:I46	R:R:L44	5.71	No	No	0	5	2
60	R:R:L44	R:R:N47	4.12	No	No	0	2	4
61	R:R:D297	R:R:N47	5.39	No	No	0	4	4
62	R:R:K48	R:R:Y49	4.78	No	No	0	4	2
63	R:R:K48	R:R:V52	3.04	No	No	0	4	5
64	R:R:I53	R:R:Y49	13.3	No	No	0	5	2
65	R:R:V51	R:R:Y55	5.05	Yes	Yes	4	5	7
66	R:R:K108	R:R:V51	3.04	Yes	Yes	4	5	5
67	R:R:I301	R:R:V51	4.61	No	Yes	4	5	5
68	R:R:V109	R:R:V52	3.21	No	No	0	4	5
69	R:R:L101	R:R:Y55	4.69	No	Yes	0	8	7
70	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
71	R:R:K108	R:R:Y55	4.78	Yes	Yes	4	5	7
72	R:R:E300	R:R:Y55	7.86	No	Yes	4	5	7
73	R:R:I301	R:R:Y55	4.84	No	Yes	4	5	7
74	R:R:F59	R:R:P102	11.56	No	No	0	7	9
75	R:R:A98	R:R:S62	3.42	No	No	0	5	8
76	R:R:S307	R:R:S62	6.52	Yes	No	8	8	8
77	R:R:L64	R:R:L68	6.92	No	No	0	4	6
78	R:R:G65	R:R:P311	4.06	No	No	0	7	9
79	R:R:D94	R:R:N66	12.12	No	No	0	9	9
80	R:R:L95	R:R:N66	4.12	No	No	0	7	9
81	R:R:N66	R:R:P311	3.26	No	No	0	9	9
82	R:R:I73	R:R:V69	3.07	Yes	No	0	6	8
83	R:R:A91	R:R:M70	3.22	No	No	0	8	6
84	R:R:L71	R:R:Y75	3.52	No	No	0	3	4
85	R:R:F321	R:R:V72	3.93	Yes	No	0	8	7
86	R:R:L325	R:R:V72	4.47	No	No	0	6	7
87	R:R:I73	R:R:R80	3.76	Yes	No	0	6	7
88	R:R:I73	R:R:L88	8.56	Yes	Yes	0	6	5
89	R:R:F321	R:R:I73	5.02	Yes	Yes	0	8	6
90	R:R:L74	R:R:L88	4.15	No	Yes	0	2	5
91	R:R:I328	R:R:Y75	7.25	No	No	0	5	4
92	R:R:R77	R:R:R80	3.2	No	No	0	6	7
93	R:R:D84	R:R:S81	8.83	No	No	0	8	7
94	R:R:D143	R:R:V82	5.84	No	No	1	8	7
95	R:R:R159	R:R:V82	3.92	Yes	No	1	3	7
96	R:R:V162	R:R:V82	4.81	No	No	0	7	7
97	R:R:N89	R:R:V85	4.43	No	No	0	9	6
98	R:R:V162	R:R:V85	6.41	No	No	0	7	6
99	R:R:C139	R:R:Y86	4.03	No	Yes	1	5	7
100	R:R:I140	R:R:Y86	6.04	No	Yes	1	9	7
101	R:R:D143	R:R:Y86	4.6	No	Yes	1	8	7
102	R:R:V162	R:R:Y86	8.83	No	Yes	0	7	7
103	R:R:I165	R:R:Y86	3.63	No	Yes	1	5	7
104	R:R:A315	R:R:L87	4.73	No	No	9	7	7
105	R:R:F321	R:R:L87	3.65	Yes	No	9	8	7
106	R:R:L88	R:R:N89	4.12	Yes	No	0	5	9
107	R:R:C166	R:R:N89	7.87	No	No	0	7	9
108	R:R:L136	R:R:L90	4.15	No	Yes	1	8	9
109	R:R:L90	R:R:N310	6.87	Yes	Yes	1	9	9
110	R:R:L90	R:R:Y314	3.52	Yes	Yes	1	9	9
111	R:R:L92	R:R:L96	4.15	No	No	0	6	7
112	R:R:L92	R:R:W170	4.56	No	Yes	0	6	9
113	R:R:D94	R:R:S307	4.42	No	Yes	0	9	8
114	R:R:D94	R:R:N310	8.08	No	Yes	0	9	9
115	R:R:L96	R:R:N129	6.87	No	No	0	7	8
116	R:R:F97	R:R:L101	4.87	Yes	No	0	6	8
117	R:R:F97	R:R:K126	9.93	Yes	No	0	6	6
118	R:R:F97	R:R:N129	4.83	Yes	No	0	6	8
119	R:R:F97	R:R:I304	3.77	Yes	No	0	6	7
120	R:R:L125	R:R:T100	4.42	No	No	0	4	7
121	R:R:I103	R:R:W112	4.7	No	Yes	2	6	9
122	R:R:F114	R:R:I103	5.02	Yes	No	2	6	6
123	R:R:I103	R:R:V122	7.68	No	No	2	6	5
124	R:R:K108	R:R:W104	5.8	Yes	No	0	5	6
125	R:R:W104	R:R:W112	3.75	No	Yes	0	6	9
126	R:R:K126	R:R:W104	13.92	No	No	0	6	6
127	R:R:S107	R:R:W112	6.18	No	Yes	0	5	9
128	R:R:E300	R:R:K108	8.1	No	Yes	4	5	5
129	R:R:F114	R:R:W112	5.01	Yes	Yes	2	6	9
130	R:R:C119	R:R:W112	6.53	No	Yes	2	9	9
131	R:R:V122	R:R:W112	3.68	No	Yes	2	5	9
132	R:R:C196	R:R:W112	9.14	No	Yes	2	9	9
133	R:R:I113	R:R:P194	5.08	No	No	0	3	5
134	R:R:K120	R:R:T116	4.5	No	No	0	7	3
135	R:R:T116	R:R:T186	6.28	No	No	0	3	4
136	R:R:F117	R:R:V121	5.24	No	No	0	1	5
137	R:R:C119	R:R:C196	7.28	No	No	2	9	9
138	R:R:R184	R:R:S123	10.54	No	No	0	5	5
139	R:R:C196	R:R:S123	3.44	No	No	0	9	5
140	R:R:L124	R:R:L181	8.3	No	No	0	6	5
141	R:R:E127	R:R:Y131	3.37	No	No	0	4	7
142	R:R:E127	R:R:V180	8.56	No	No	0	4	4
143	R:R:L174	R:R:V128	5.96	No	No	0	5	5
144	R:R:A177	R:R:V128	3.39	No	No	0	7	5
145	R:R:F130	R:R:I134	6.28	No	No	10	7	8
146	R:R:F130	R:R:W264	6.01	No	Yes	10	7	8
147	R:R:L176	R:R:Y131	3.52	No	No	0	4	7
148	R:R:P215	R:R:Y131	5.56	No	No	0	5	7
149	R:R:S132	R:R:W170	16.06	No	Yes	0	6	9
150	R:R:S132	R:R:S173	4.89	No	No	0	6	7
151	R:R:I134	R:R:P223	3.39	No	No	0	8	9
152	R:R:I134	R:R:W264	7.05	No	Yes	10	8	8
153	R:R:I169	R:R:L135	8.56	No	No	0	6	6
154	R:R:L137	R:R:Y314	8.21	No	Yes	0	8	9
155	R:R:A138	R:R:I226	3.25	No	No	0	7	6
156	R:R:C139	R:R:I165	3.27	No	No	1	5	5
157	R:R:C139	R:R:I169	3.27	No	No	0	5	6
158	R:R:I140	R:R:R144	6.26	No	No	1	9	9
159	R:R:I140	R:R:Y314	4.84	No	Yes	1	9	9
160	R:R:M227	R:R:S141	6.13	No	No	1	8	9
161	R:R:S141	R:R:Y231	5.09	No	Yes	1	9	9
162	R:R:C230	R:R:V142	3.42	No	No	0	7	6
163	R:R:D143	R:R:R159	9.53	No	Yes	1	8	3
164	R:R:R144	R:R:Y231	9.26	No	Yes	1	9	9
165	R:R:R144	R:R:Y314	6.17	No	Yes	1	9	9
166	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
167	R:R:V149	R:R:Y145	12.62	Yes	Yes	5	7	8
168	R:R:H150	R:R:Y145	8.71	Yes	Yes	5	6	8
169	R:R:F229	R:R:Y145	3.09	No	Yes	5	4	8
170	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
171	R:R:F233	R:R:Y145	4.13	No	Yes	5	4	8
172	R:R:I148	R:R:T234	4.56	No	Yes	0	8	8
173	R:R:H150	R:R:V149	4.15	Yes	Yes	5	6	7
174	R:R:T234	R:R:V149	3.17	Yes	Yes	0	8	7
175	R:R:T237	R:R:V149	6.35	No	Yes	0	5	7
176	R:R:H150	R:R:R153	9.03	Yes	No	0	6	5
177	R:R:H150	R:R:L155	9	Yes	No	0	6	4
178	R:R:L172	R:R:L176	5.54	No	No	0	4	4
179	R:R:F218	R:R:L176	3.65	No	No	0	4	4
180	R:R:R184	R:R:V180	9.15	No	No	0	5	4
181	R:R:F183	R:R:L182	13.4	No	No	0	5	4
182	R:R:E198	R:R:R184	10.47	No	No	0	5	5
183	R:R:D199	R:R:R185	22.63	No	No	0	4	4
184	R:R:T186	R:R:Y188	6.24	No	No	0	4	1
185	R:R:V187	R:R:Y197	5.05	No	No	0	3	3
186	R:R:P194	R:R:Y188	5.56	No	No	0	5	1
187	R:R:S189	R:R:V192	4.85	No	Yes	0	1	5
188	R:R:N191	R:R:V192	5.91	No	Yes	0	2	5
189	R:R:P194	R:R:S193	3.56	No	No	0	5	3
190	R:R:R208	R:R:Y197	19.55	Yes	No	0	4	3
191	R:R:E198	R:R:R208	17.45	No	Yes	0	5	4
192	R:R:M200	R:R:T204	7.53	Yes	No	0	5	3
193	R:R:M200	R:R:W207	4.65	Yes	No	0	5	3
194	R:R:L211	R:R:M200	4.24	No	Yes	0	4	5
195	R:R:N203	R:R:N206	13.62	No	No	0	4	1
196	R:R:L210	R:R:W207	3.42	No	No	0	2	3
197	R:R:M209	R:R:T275	4.52	No	No	0	3	4
198	R:R:M209	R:R:R278	3.72	No	Yes	0	3	4
199	R:R:Q216	R:R:R212	3.5	No	Yes	0	5	5
200	R:R:D274	R:R:R212	8.34	No	Yes	0	4	5
201	R:R:R212	R:R:T275	6.47	Yes	No	0	5	4
202	R:R:L214	R:R:P215	3.28	No	No	0	3	5
203	R:R:N268	R:R:Q216	10.56	No	No	0	8	5
204	R:R:L271	R:R:Q216	5.32	No	No	0	6	5
205	R:R:F218	R:R:V222	5.24	No	No	0	4	5
206	R:R:G219	R:R:P223	4.06	No	No	0	5	9
207	R:R:F220	R:R:F260	4.29	Yes	No	0	8	9
208	R:R:F220	R:R:L265	3.65	Yes	Yes	0	8	6
209	R:R:F220	R:R:N268	15.71	Yes	No	0	8	8
210	R:R:P223	R:R:V222	3.53	No	No	0	9	5
211	R:R:I226	R:R:V222	3.07	No	No	0	6	5
212	R:R:L224	R:R:L228	9.69	No	No	0	7	4
213	R:R:M227	R:R:Y231	4.79	No	Yes	1	8	9
214	R:R:F260	R:R:M227	9.95	No	No	0	9	8
215	R:R:F229	R:R:F233	10.72	No	No	5	4	4
216	R:R:I253	R:R:Y231	12.09	No	Yes	0	7	9
217	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
218	R:R:I253	R:R:T234	3.04	No	Yes	0	7	8
219	R:R:I253	R:R:L235	4.28	No	No	0	7	4
220	R:R:A249	R:R:L238	3.15	No	No	0	7	8
221	R:R:H247	R:R:K246	9.17	No	No	0	5	7
222	R:R:K246	R:R:M250	7.2	No	No	0	7	5
223	R:R:I317	R:R:V252	7.68	No	No	0	6	7
224	R:R:I313	R:R:V256	3.07	Yes	No	1	7	8
225	R:R:V256	R:R:Y314	3.79	No	Yes	1	8	9
226	R:R:I259	R:R:I313	7.36	No	Yes	0	6	7
227	R:R:F260	R:R:W264	5.01	No	Yes	0	9	8
228	R:R:L261	R:R:L265	5.54	No	Yes	0	6	6
229	R:R:W264	R:R:Y267	6.75	Yes	No	0	8	7
230	R:R:H306	R:R:W264	8.46	No	Yes	0	9	8
231	R:R:L265	R:R:P266	3.28	Yes	No	0	6	9
232	R:R:L265	R:R:L269	5.54	Yes	No	0	6	6
233	R:R:P266	R:R:T299	3.5	No	No	0	9	6
234	R:R:N268	R:R:Y267	3.49	No	No	0	8	7
235	R:R:L271	R:R:Y267	12.89	No	No	0	6	7
236	R:R:T299	R:R:V270	6.35	No	No	0	6	4
237	R:R:L271	R:R:L296	4.15	No	No	0	6	5
238	R:R:L272	R:R:L276	4.15	No	No	0	5	4
239	R:R:D274	R:R:R278	5.96	No	Yes	0	4	4
240	R:R:I282	R:R:L276	5.71	No	No	0	5	4
241	R:R:E284	R:R:M277	6.77	No	No	0	3	4
242	R:R:I292	R:R:M277	4.37	No	No	0	5	4
243	R:R:T279	R:R:V281	4.76	No	No	0	1	4
244	R:R:E284	R:R:Q280	11.47	No	No	0	3	2
245	R:R:I282	R:R:Q283	4.12	No	No	11	5	2
246	R:R:I282	R:R:R288	6.26	No	Yes	11	5	1
247	R:R:Q283	R:R:R288	10.51	No	Yes	11	2	1
248	R:R:E287	R:R:T285	11.29	No	No	0	4	5
249	R:R:C308	R:R:L305	4.76	Yes	No	0	7	5
250	R:R:H306	R:R:N310	3.83	No	Yes	0	9	9
251	R:R:I313	R:R:L309	5.71	Yes	No	0	7	6
252	R:R:N310	R:R:Y314	3.49	Yes	Yes	1	9	9
253	R:R:I313	R:R:Y314	6.04	Yes	Yes	1	7	9
254	R:R:A315	R:R:F321	8.32	No	Yes	9	7	8
255	R:R:Q319	R:R:R322	4.67	No	No	0	5	8
256	R:R:H323	R:R:Q319	7.42	No	No	0	4	5
257	R:R:F321	R:R:K320	4.96	Yes	No	0	8	6
258	R:R:H323	R:R:K327	5.24	No	No	0	4	4
259	R:R:M209	R:R:T279	3.01	No	No	0	3	1
260	R:R:L63	R:R:S67	3	No	No	0	5	3
261	R:R:K126	R:R:T100	3	No	No	0	6	7
262	L:L:L92	L:L:V58	2.98	No	No	0	9	8
263	L:L:L84	L:L:V90	2.98	No	Yes	0	8	5
264	L:L:L92	L:L:V90	2.98	No	Yes	0	9	5
265	L:L:L84	L:L:T62	2.95	No	No	0	8	4
266	R:R:L87	R:R:T83	2.95	No	No	0	7	7
267	L:L:Q67	R:R:S190	2.89	No	No	0	6	2
268	R:R:F183	R:R:P179	2.89	No	No	0	5	8
269	R:R:F316	R:R:P311	2.89	No	No	0	6	9
270	R:R:I165	R:R:L161	2.85	No	No	0	5	4
271	R:R:I213	R:R:L210	2.85	No	No	0	4	2
272	R:R:I221	R:R:L225	2.85	No	No	0	4	3
273	R:R:L88	R:R:M70	2.83	Yes	No	0	5	6
274	R:R:L235	R:R:M250	2.83	No	No	0	4	5
275	R:R:K158	R:R:L155	2.82	No	No	0	6	4
276	R:R:K327	R:R:L326	2.82	No	No	0	4	4
277	R:R:G115	R:R:W112	2.81	No	Yes	0	8	9
278	L:L:A96	L:L:F98	2.77	No	No	0	8	2
279	R:R:A98	R:R:F59	2.77	No	No	0	5	7
280	R:R:L63	R:R:L95	2.77	No	No	0	5	7
281	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
282	R:R:A147	R:R:R159	2.77	No	Yes	0	8	3
283	R:R:L224	R:R:L261	2.77	No	No	0	7	6
284	R:R:A93	R:R:W170	2.59	No	Yes	0	8	9
285	R:R:R159	R:R:T156	2.59	Yes	No	0	3	2
286	R:R:R208	R:R:T204	2.59	Yes	No	0	4	3
287	R:R:R288	R:R:T285	2.59	Yes	No	0	1	5
288	R:R:F50	R:R:I46	2.51	No	No	0	5	5
289	R:R:F183	R:R:M200	2.49	No	Yes	0	5	5
290	R:R:F164	R:R:K163	2.48	No	No	0	3	4
291	R:R:M277	R:R:R288	2.48	No	Yes	0	4	1
292	R:R:V128	R:R:W170	2.45	No	Yes	0	5	9
293	R:R:F316	R:R:L68	2.44	No	No	0	6	6
294	R:R:T186	R:R:W112	2.43	No	Yes	0	4	9
295	R:R:D84	R:R:F321	2.39	No	Yes	0	8	8
296	R:R:R248	R:R:R322	2.13	No	No	0	7	8
297	L:L:A96	L:L:P97	1.87	No	No	0	8	7
298	R:R:A37	R:R:P38	1.87	No	No	0	7	7
299	L:L:G64	L:L:S83	1.86	No	No	0	4	8
300	R:R:G111	R:R:S107	1.86	No	No	0	4	5
301	R:R:G111	R:R:S193	1.86	No	No	0	4	3
302	R:R:G201	R:R:T204	1.82	No	No	0	4	3
303	L:L:G64	L:L:I63	1.76	No	No	0	4	8
304	R:R:G318	R:R:I317	1.76	No	No	0	7	6
305	R:R:G244	R:R:M243	1.75	No	No	0	4	4
306	R:R:G324	R:R:K320	1.74	No	No	0	5	6
307	R:R:C308	R:R:S62	1.72	Yes	No	8	7	8
308	R:R:C308	R:R:S307	1.72	Yes	Yes	8	7	8
309	R:R:G133	R:R:L90	1.71	No	Yes	1	9	9
310	R:R:G133	R:R:L136	1.71	No	No	1	9	8
311	R:R:G232	R:R:L235	1.71	No	No	0	3	4
312	R:R:G303	R:R:L302	1.71	No	No	0	7	7
313	L:L:A82	L:L:V90	1.7	No	Yes	0	9	5
314	R:R:A295	R:R:V270	1.7	No	No	0	5	4
315	R:R:L178	R:R:P179	1.64	No	No	0	3	8
316	R:R:G244	R:R:Q245	1.64	No	No	0	4	4
317	R:R:C263	R:R:I259	1.64	No	No	0	7	6
318	R:R:L302	R:R:P266	1.64	No	No	0	7	9
319	L:L:V43	R:R:S193	1.62	No	No	0	3	3
320	L:L:C75	L:L:K77	1.62	No	Yes	0	9	4
321	R:R:S307	R:R:V58	1.62	Yes	No	0	8	7
322	R:R:A273	R:R:I292	1.62	No	No	0	5	5
323	R:R:A241	R:R:M243	1.61	No	No	0	3	4
324	R:R:V51	R:R:V52	1.6	Yes	No	0	5	5
325	R:R:V252	R:R:V256	1.6	No	No	0	7	8
326	R:R:C308	R:R:L61	1.59	Yes	No	0	7	5
327	R:R:C263	R:R:L262	1.59	No	No	0	7	5
328	R:R:G324	R:R:H323	1.59	No	No	0	5	4
329	R:R:A177	R:R:L124	1.58	No	No	0	7	6
330	R:R:E40	R:R:P41	1.57	No	No	0	4	4
331	R:R:A205	R:R:N206	1.56	No	No	0	1	1
332	R:R:I328	R:R:S76	1.55	No	No	0	5	4
333	R:R:I54	R:R:V58	1.54	No	No	0	5	7
334	R:R:A298	R:R:D297	1.54	No	No	0	5	4
335	L:L:K77	L:L:S76	1.53	Yes	No	0	4	4
336	L:L:L56	L:L:V54	1.49	No	No	0	7	7
337	L:L:L99	L:L:V102	1.49	Yes	No	0	7	6
338	R:R:N47	R:R:V51	1.48	No	Yes	0	4	5
339	R:R:N110	R:R:V109	1.48	No	No	0	4	4
340	R:R:L238	R:R:T234	1.47	No	Yes	0	8	8
341	L:L:F69	L:L:P70	1.44	Yes	No	0	4	6
342	R:R:K246	R:R:M243	1.44	No	No	0	7	4
343	R:R:I53	R:R:L57	1.43	No	No	0	5	5
344	R:R:I259	R:R:L258	1.43	No	No	0	6	5
345	R:R:Q157	R:R:T156	1.42	No	No	0	7	2
346	L:L:E46	L:L:T45	1.41	Yes	No	0	7	1
347	R:R:G171	R:R:W170	1.41	No	Yes	0	4	9
348	R:R:L60	R:R:L64	1.38	No	No	0	4	4
349	R:R:L96	R:R:L99	1.38	No	No	0	7	4
350	R:R:L172	R:R:L175	1.38	No	No	0	4	4
351	R:R:L326	R:R:L329	1.38	No	No	0	4	6
352	R:R:E45	R:R:I46	1.37	No	No	0	4	5
353	L:L:R57	L:L:T55	1.29	No	No	0	3	6
354	R:R:R153	R:R:T152	1.29	No	No	0	5	5
355	R:R:F220	R:R:I221	1.26	Yes	No	0	8	4
356	R:R:E287	R:R:H291	1.23	No	No	0	4	3
357	R:R:F114	R:R:L118	1.22	Yes	No	0	6	6
358	R:R:F254	R:R:L258	1.22	No	No	0	4	5
359	L:L:L52	L:L:R53	1.21	Yes	No	0	7	3
360	R:R:L44	R:R:R294	1.21	No	No	0	2	2
361	R:R:H247	R:R:R251	1.13	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E46	5.2975	4	0	7
2	L:L:L52	4.335	4	6	7
3	L:L:F69	7.412	5	3	4
4	L:L:K77	2.385	4	0	4
5	L:L:E79	8.946	5	3	9
6	L:L:V80	4.945	4	7	8
7	L:L:V90	3.105	4	0	5
8	L:L:L99	3.44	4	0	7
9	R:R:V51	3.156	5	4	5
10	R:R:Y55	5.20333	6	4	7
11	R:R:I73	5.1025	4	0	6
12	R:R:Y86	5.426	5	1	7
13	R:R:L88	4.915	4	0	5
14	R:R:L90	4.0625	4	1	9
15	R:R:F97	5.85	4	0	6
16	R:R:K108	5.43	4	4	5
17	R:R:W112	4.91444	9	2	9
18	R:R:F114	3.505	4	2	6
19	R:R:Y145	6.465	6	5	8
20	R:R:V149	6.5725	4	5	7
21	R:R:H150	7.7225	4	5	6
22	R:R:R159	4.7025	4	1	3
23	R:R:W170	5.414	5	0	9
24	R:R:V192	5.67	4	0	5
25	R:R:M200	4.7275	4	0	5
26	R:R:R208	12.515	4	0	4
27	R:R:R212	5.45	4	0	5
28	R:R:F220	6.2275	4	0	8
29	R:R:Y231	7.256	5	1	9
30	R:R:T234	3.06	4	0	8
31	R:R:W264	6.656	5	10	8
32	R:R:L265	4.5025	4	0	6
33	R:R:R278	8.14	4	0	4
34	R:R:R288	5.46	4	11	1
35	R:R:S307	3.57	4	8	8
36	R:R:C308	2.4475	4	8	7
37	R:R:N310	5.5675	4	1	9
38	R:R:I313	5.545	4	1	7
39	R:R:Y314	5.15143	7	1	9
40	R:R:F321	4.71167	6	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L47	R:R:V192	41.8136	5.96	No	Yes	0	8	5
2	L:L:L47	R:R:Y197	42.4689	9.38	No	No	0	8	3
3	R:R:R208	R:R:Y197	47.5749	19.55	Yes	No	0	4	3
4	R:R:E198	R:R:R208	49.5956	17.45	No	Yes	0	5	4
5	R:R:E198	R:R:R184	49.0388	10.47	No	No	0	5	5
6	R:R:R184	R:R:S123	48.0086	10.54	No	No	0	5	5
7	R:R:C196	R:R:S123	47.3911	3.44	No	No	0	9	5
8	R:R:C196	R:R:W112	46.0275	9.14	No	Yes	2	9	9
9	L:L:E46	R:R:R208	81.6348	10.47	Yes	Yes	0	7	4
10	L:L:E46	R:R:R212	86.2143	3.49	Yes	Yes	0	7	5
11	L:L:E46	R:R:R278	19.1379	5.82	Yes	Yes	0	7	4
12	L:L:R48	R:R:R278	28.4351	17.06	No	Yes	0	9	4
13	L:L:R48	R:R:R289	25.795	20.26	No	No	0	9	3
14	L:L:A96	L:L:F98	10.0945	2.77	No	No	0	8	2
15	L:L:F98	L:L:L99	10.9127	3.65	No	Yes	0	2	7
16	L:L:L92	L:L:L99	15.744	4.15	No	Yes	0	9	7
17	L:L:L92	L:L:V90	17.3122	2.98	No	Yes	0	9	5
18	L:L:A82	L:L:V90	24.9882	1.7	No	Yes	0	9	5
19	L:L:A82	L:L:I63	25.7344	4.87	No	No	0	9	8
20	L:L:G64	L:L:I63	26.4768	1.76	No	No	0	4	8
21	L:L:G64	L:L:S83	27.2154	1.86	No	No	0	4	8
22	L:L:Q89	L:L:S83	28.6813	4.33	No	No	0	4	8
23	L:L:Q89	L:L:V81	30.8517	4.3	No	No	0	4	9
24	L:L:F69	L:L:V81	31.2646	5.24	Yes	No	3	4	9
25	L:L:F69	L:L:Q74	37.1091	3.51	Yes	No	0	4	8
26	L:L:Q74	R:R:S189	37.8023	5.78	No	No	0	8	1
27	R:R:S189	R:R:V192	38.4803	4.85	No	Yes	0	1	5
28	L:L:L52	R:R:R289	21.7458	6.07	Yes	No	6	7	3
29	L:L:L52	R:R:E284	17.8235	5.3	Yes	No	0	7	3
30	R:R:W104	R:R:W112	34.2475	3.75	No	Yes	0	6	9
31	R:R:K108	R:R:W104	18.1	5.8	Yes	No	0	5	6
32	R:R:K108	R:R:V51	13.4221	3.04	Yes	Yes	4	5	5
33	R:R:K126	R:R:W104	15.7592	13.92	No	No	0	6	6
34	R:R:F97	R:R:K126	13.4069	9.93	Yes	No	0	6	6
35	R:R:Q216	R:R:R212	100	3.5	No	Yes	0	5	5
36	R:R:N268	R:R:Q216	66.8851	10.56	No	No	0	8	5
37	R:R:N268	R:R:Y267	32.8479	3.49	No	No	0	8	7
38	R:R:W264	R:R:Y267	65.3491	6.75	Yes	No	0	8	7
39	R:R:H306	R:R:W264	65.3283	8.46	No	Yes	0	9	8
40	R:R:H306	R:R:N310	64.6692	3.83	No	Yes	0	9	9
41	R:R:D94	R:R:N310	20.7988	8.08	No	Yes	0	9	9
42	R:R:D94	R:R:S307	10.1116	4.42	No	Yes	0	9	8
43	R:R:L271	R:R:Q216	33.3857	5.32	No	No	0	6	5
44	R:R:L271	R:R:Y267	33.1395	12.89	No	No	0	6	7
45	R:R:D94	R:R:N66	10.1116	12.12	No	No	0	9	9
46	R:R:F220	R:R:N268	34.1774	15.71	Yes	No	0	8	8
47	R:R:F220	R:R:F260	32.613	4.29	Yes	No	0	8	9
48	R:R:F260	R:R:M227	32.2683	9.95	No	No	0	9	8
49	R:R:M227	R:R:Y231	31.5638	4.79	No	Yes	1	8	9
50	R:R:R144	R:R:Y231	23.0734	9.26	No	Yes	1	9	9
51	R:R:I140	R:R:R144	19.9352	6.26	No	No	1	9	9
52	R:R:I140	R:R:Y86	55.4819	6.04	No	Yes	1	9	7
53	R:R:V162	R:R:Y86	40.0125	8.83	No	Yes	0	7	7
54	R:R:V162	R:R:V85	37.7133	6.41	No	No	0	7	6
55	R:R:N89	R:R:V85	36.416	4.43	No	No	0	9	6
56	R:R:L88	R:R:N89	33.81	4.12	Yes	No	0	5	9
57	R:R:I73	R:R:L88	28.5525	8.56	Yes	Yes	0	6	5
58	R:R:N310	R:R:Y314	48.0237	3.49	Yes	Yes	1	9	9
59	R:R:I140	R:R:Y314	36.7607	4.84	No	Yes	1	9	9
60	R:R:F321	R:R:I73	23.2344	5.02	Yes	Yes	0	8	6
61	R:R:F97	R:R:N129	11.6646	4.83	Yes	No	0	6	8
62	R:R:L96	R:R:N129	10.8559	6.87	No	No	0	7	8
63	R:R:I253	R:R:Y231	17.0205	12.09	No	Yes	0	7	9
64	R:R:I253	R:R:T234	10.6873	3.04	No	Yes	0	7	8
65	R:R:D274	R:R:R212	12.388	8.34	No	Yes	0	4	5
66	R:R:D274	R:R:R278	11.9032	5.96	No	Yes	0	4	4
67	R:R:E284	R:R:M277	15.1228	6.77	No	No	0	3	4
68	R:R:M277	R:R:R288	11.0434	2.48	No	Yes	0	4	1
69	R:R:F321	R:R:K320	12.4126	4.96	Yes	No	0	8	6
70	R:R:G324	R:R:K320	11.0434	1.74	No	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V43	R:R:S43	3.23	0	No	No	3	5	0	1
L:L:L44	R:R:P41	6.57	0	No	No	3	4	0	1
L:L:L44	R:R:V192	5.96	0	No	Yes	3	5	0	1
L:L:E46	R:R:R208	10.47	0	Yes	Yes	7	4	0	1
L:L:E46	R:R:R212	3.49	0	Yes	Yes	7	5	0	1
L:L:E46	R:R:R278	5.82	0	Yes	Yes	7	4	0	1
L:L:L47	R:R:V192	5.96	0	No	Yes	8	5	0	1
L:L:L47	R:R:Y197	9.38	0	No	No	8	3	0	1
L:L:R48	R:R:R278	17.06	0	No	Yes	9	4	0	1
L:L:R48	R:R:R289	20.26	0	No	No	9	3	0	1
L:L:R48	R:R:D293	10.72	0	No	No	9	4	0	1
L:L:L52	R:R:C39	4.76	6	Yes	No	7	8	0	1
L:L:L52	R:R:E284	5.3	6	Yes	No	7	3	0	1
L:L:L52	R:R:R289	6.07	6	Yes	No	7	3	0	1
L:L:R53	R:R:D35	13.1	0	No	No	3	6	0	1
L:L:T55	R:R:A36	3.36	0	No	No	6	5	0	1
L:L:A71	R:R:N202	6.25	0	No	No	6	2	0	1
L:L:G72	R:R:N202	3.39	0	No	No	8	2	0	1
L:L:P73	R:R:V187	7.07	0	No	No	7	3	0	1
L:L:P73	R:R:D199	4.83	0	No	No	7	4	0	1
L:L:Q74	R:R:S189	5.78	0	No	No	8	1	0	1
L:L:Q89	R:R:P38	6.32	0	No	No	4	7	0	1
R:R:C286	R:R:C39	7.28	0	No	No	6	8	2	1
R:R:C39	R:R:R289	8.36	6	No	No	8	3	1	1
R:R:D199	R:R:R185	22.63	0	No	No	4	4	1	2
R:R:V187	R:R:Y197	5.05	0	No	No	3	3	1	1
R:R:S189	R:R:V192	4.85	0	No	Yes	1	5	1	1
R:R:N191	R:R:V192	5.91	0	No	Yes	2	5	2	1
R:R:P194	R:R:S193	3.56	0	No	No	5	3	2	1
R:R:R208	R:R:Y197	19.55	0	Yes	No	4	3	1	1
R:R:E198	R:R:R208	17.45	0	No	Yes	5	4	2	1
R:R:M209	R:R:T275	4.52	0	No	No	3	4	2	2
R:R:M209	R:R:R278	3.72	0	No	Yes	3	4	2	1
R:R:Q216	R:R:R212	3.5	0	No	Yes	5	5	2	1
R:R:D274	R:R:R212	8.34	0	No	Yes	4	5	2	1
R:R:R212	R:R:T275	6.47	0	Yes	No	5	4	1	2
R:R:D274	R:R:R278	5.96	0	No	Yes	4	4	2	1
R:R:E284	R:R:M277	6.77	0	No	No	3	4	1	2
R:R:E284	R:R:Q280	11.47	0	No	No	3	2	1	2
L:L:Q67	R:R:S190	2.89	0	No	No	6	2	0	1
R:R:R208	R:R:T204	2.59	0	Yes	No	4	3	1	2
R:R:A37	R:R:P38	1.87	0	No	No	7	7	2	1
R:R:G111	R:R:S193	1.86	0	No	No	4	3	2	1
L:L:V43	R:R:S193	1.62	0	No	No	3	3	0	1
R:R:E40	R:R:P41	1.57	0	No	No	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XXX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	335
Number of Links	361
Number of Hubs	40
Number of Links mediated by Hubs	160
Number of Communities	11
Number of Nodes involved in Communities	57
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	81574
Length Of Smallest Path	3
Average Path Length	19.3035
Length of Longest Path	46
Minimum Path Strength	1.325
Average Path Strength	6.65936
Maximum Path Strength	18.66
Minimum Path Correlation	0.7
Average Path Correlation	0.948685
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.38095
Average % Of Corr. Nodes	52.2048
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.9222
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • molecular function activator activity • signaling receptor binding • G protein-coupled receptor binding • signaling receptor activator activity • protein binding • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • CXCR chemokine receptor binding • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • regulation of immune effector process • neutrophil-mediated killing of symbiont cell • regulation of myeloid leukocyte mediated immunity • regulation of cellular process • biological process involved in interspecies interaction between organisms • regulation of killing of cells of another organism • disruption of cell in another organism • defense response to Gram-negative bacterium
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • regulation of immune effector process • neutrophil-mediated killing of symbiont cell • regulation of myeloid leukocyte mediated immunity • regulation of cellular process • biological process involved in interspecies interaction between organisms • regulation of killing of cells of another organism • disruption of cell in another organism • defense response to Gram-negative bacterium • myeloid leukocyte mediated immunity • response to biotic stimulus • biological process involved in symbiotic interaction • regulation of neutrophil mediated killing of bacterium • defense response to bacterium • neutrophil mediated immunity • response to bacterium • response to stress • leukocyte mediated immunity • regulation of immune system process • response to external biotic stimulus • regulation of neutrophil mediated killing of gram-negative bacterium • modulation of process of another organism • killing of cells of another organism • regulation of biological process involved in symbiotic interaction • neutrophil-mediated killing of bacterium • regulation of biological process • neutrophil mediated cytotoxicity • regulation of neutrophil mediated cytotoxicity • response to other organism • defense response • biological regulation • regulation of leukocyte mediated cytotoxicity • leukocyte mediated cytotoxicity • immune effector process • regulation of neutrophil mediated killing of symbiont cell • regulation of leukocyte mediated immunity • neutrophil-mediated killing of gram-negative bacterium • immune system process • regulation of cell killing • cellular process • disruption of anatomical structure in another organism • cell killing • humoral immune response • immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • neutrophil activation • multicellular organismal process • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • cellular response to stimulus • neutrophil chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • inflammatory response • multicellular organismal-level homeostasis • leukocyte homeostasis • homeostatic process • homeostasis of number of cells • cell surface receptor signaling pathway • signaling • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • cell communication • response to peptide • G protein-coupled receptor signaling pathway • cellular response to cytokine stimulus • signal transduction • cell-cell signaling • response to lipid • cellular response to lipopolysaccharide • response to oxygen-containing compound • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to oxygen-containing compound • cellular response to biotic stimulus • cellular response to lipid • response to molecule of bacterial origin • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • regulation of cytokine production • cytokine production • chemokine production • regulation of macromolecule biosynthetic process • metabolic process • regulation of multicellular organismal process • macromolecule metabolic process • regulation of metabolic process • antibacterial innate immune response • innate immune response • cellular anatomical structure • extracellular region • extracellular space • G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • protein binding • binding • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular defense response • cellular response to interleukin-8 • response to interleukin-8 • interleukin-8-mediated signaling pathway • cell periphery • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • mast cell granule • organelle • cytoplasm • lysosome • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • organelle membrane • secretory granule membrane • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • heart process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • behavior • locomotory behavior • secretion • export from cell • membrane docking • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • GABA-ergic synapse • glutamatergic synapse • cell body • G-protein beta-subunit binding • fibroblast proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	CXCL6
UniProt	P80162
Sequence	>8XXX_nogp_Chain_L A V L T E L R C T C L R V T L R V N P K T I G K L Q V F P A G P Q C S K V E V V A S L K N G K Q V C L D P E A P F L K K V I Q K I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XXX_nogp_Chain_R L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

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