Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 3.5125488
2A:A:L23 3.54486
3A:A:V34 5.2965124
4A:A:L36 3.7665127
5A:A:L37 3.332529
6A:A:L38 3.855408
7A:A:L39 3.22429
8A:A:F192 4.8954125
9A:A:H196 4.0775403
10A:A:F197 6.3845127
11A:A:R198 9.785426
12A:A:F200 9.188526
13A:A:V202 4.3325429
14A:A:K211 7.286109
15A:A:W212 4.79833629
16A:A:H214 5.405428
17A:A:C215 3.5725426
18A:A:F216 4.09714729
19A:A:I222 3.2775427
20A:A:F224 4.702509
21A:A:V226 4.875407
22A:A:F251 7.08429
23A:A:F259 7.29524
24A:A:I265 3.2225426
25A:A:I266 3.5408
26A:A:L267 3.864169
27A:A:F268 3.9725139
28A:A:L269 4.874168
29A:A:K271 3.985209
30A:A:K272 3.71254135
31A:A:I279 2.9875407
32A:A:F288 4.074218
33A:A:Y291 10.305406
34A:A:Q305 7.5454165
35A:A:F308 6.2625408
36A:A:Y320 8.5125408
37A:A:T324 5.0965139
38A:A:C325 2.854137
39A:A:F336 4.96254128
40A:A:I342 5.545406
41A:A:L348 3.6254238
42A:A:R349 8.14754224
43A:A:L353 4.675406
44A:A:Y354 7.6254225
45B:B:L30 3.2525405
46B:B:I33 2.6775403
47B:B:T34 6.005495
48B:B:I37 5.956592
49B:B:V40 4.265493
50B:B:M45 4.005434
51B:B:L51 7.4075489
52B:B:H54 8.34857789
53B:B:Y59 7.355428
54B:B:W63 8.53637
55B:B:V71 4.52254118
56B:B:D76 6.6925489
57B:B:L79 5.56254117
58B:B:I80 8.935488
59B:B:I81 4.40254117
60B:B:W82 7.27857789
61B:B:N88 5.1745197
62B:B:K89 5.33789
63B:B:H91 4.9275405
64B:B:I93 6.50254117
65B:B:L95 4.35118
66B:B:W99 7.934529
67B:B:Y105 5.1025116
68B:B:N110 5.80754184
69B:B:Y111 5.84254184
70B:B:C114 4.70254118
71B:B:L117 4.07429
72B:B:C121 3.7375458
73B:B:I123 4.0525456
74B:B:Y124 4.763336116
75B:B:E138 5.91406
76B:B:H142 6.52667659
77B:B:Y145 5.36108
78B:B:L146 3.85714757
79B:B:C149 3.4225458
80B:B:F151 4.566559
81B:B:L152 4.8775403
82B:B:I157 3.975457
83B:B:T159 6.4825459
84B:B:T165 3.7325407
85B:B:C166 3.456568
86B:B:W169 8.96833658
87B:B:D170 3.555409
88B:B:Q176 6.3325454
89B:B:F180 5.456567
90B:B:H183 7.62714769
91B:B:D186 4.9854109
92B:B:V187 6.105469
93B:B:F199 6.37286769
94B:B:S201 4.915469
95B:B:C204 3.5665107
96B:B:D205 5.325469
97B:B:K209 10.57466
98B:B:L210 5.95505
99B:B:W211 7.25167668
100B:B:Q220 6.7225477
101B:B:H225 8.19286779
102B:B:D228 8.03254109
103B:B:I229 5.125477
104B:B:F234 4.834265
105B:B:F235 7.545646
106B:B:P236 6.0025447
107B:B:T243 7.685478
108B:B:D246 6.454109
109B:B:R251 10.3925478
110B:B:F253 7.11333676
111B:B:D254 4.9525409
112B:B:D258 7.21477
113B:B:M262 4.9425444
114B:B:Y264 7.06167645
115B:B:H266 5.46444
116B:B:I269 3.3925444
117B:B:I273 4.8425446
118B:B:F278 5.74547
119B:B:R283 7.245699
120B:B:L285 6.065446
121B:B:Y289 7.95167647
122B:B:N295 8.05333646
123B:B:W297 7.184548
124B:B:D298 6.4975499
125B:B:L300 3.33143796
126B:B:K301 4.9725405
127B:B:R304 9.9475445
128B:B:H311 7.876539
129B:B:V315 4.8525437
130B:B:M325 5.2525435
131B:B:W332 10.5967629
132B:B:D333 4.692539
133B:B:L336 3.7025487
134B:B:K337 5.56536
135B:B:W339 7.794539
136G:G:V16 4.3625407
137G:G:L19 4.8625409
138G:G:R27 4.6975408
139G:G:D48 7.214599
140G:G:L51 4.9575496
141G:G:N59 5.9475439
142G:G:P60 5.102539
143G:G:F61 4.24333638
144R:R:V51 5.2375415
145R:R:Y55 4.20167617
146R:R:S62 4.0925408
147R:R:N66 4.096509
148R:R:V69 3.23254148
149R:R:V82 3.675417
150R:R:Y86 4.77667617
151R:R:L90 5.3625419
152R:R:D94 7.4225419
153R:R:F97 6.09516
154R:R:L101 4.85418
155R:R:W104 5.152516
156R:R:K108 6.4525415
157R:R:W112 6.01571719
158R:R:F114 3.605406
159R:R:E127 4.36754274
160R:R:Y131 6.174277
161R:R:I134 4.8275418
162R:R:R144 6.148519
163R:R:Y145 6.463336158
164R:R:V149 4.9654157
165R:R:H150 6.0654156
166R:R:Q157 4.3975407
167R:R:W170 4.6409
168R:R:L181 3.465405
169R:R:R212 6.036175
170R:R:F220 6.5225418
171R:R:Y231 7.615409
172R:R:L235 3.1175404
173R:R:M243 4.38404
174R:R:I253 5.9225407
175R:R:F260 4.194519
176R:R:W264 6.612518
177R:R:L271 7.72754176
178R:R:E300 5.27415
179R:R:I301 3.8775415
180R:R:I304 4.3025417
181R:R:H306 5.32419
182R:R:P311 3.4025149
183R:R:I313 4.8775417
184R:R:Y314 5.37167619
185R:R:F321 4.6325148
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I19 A:A:R15 27.08753.76YesNo084
2A:A:R15 B:B:H91 26.98543.39NoYes045
3A:A:L23 B:B:K78 25.9035.64YesNo068
4R:R:I140 R:R:R144 19.35766.26NoYes199
5R:R:I140 R:R:Y86 55.26024.84NoYes197
6R:R:D143 R:R:Y86 68.18254.6NoYes187
7R:R:D143 R:R:R159 68.38879.53NoNo183
8R:R:A147 R:R:R159 80.3825.53NoNo083
9A:A:N347 R:R:A147 80.59951.56NoNo088
10A:A:N347 R:R:A151 80.81691.56NoNo088
11A:A:I344 R:R:A151 81.24271.62NoNo078
12A:A:I344 R:R:M243 81.90364.37NoYes074
13A:A:D341 R:R:M243 82.5558.32NoYes074
14A:A:D341 A:A:Y320 82.98914.94NoYes078
15A:A:A338 A:A:Y320 42.89314NoYes078
16A:A:A338 A:A:I266 42.99644.87NoYes078
17A:A:I223 A:A:I266 86.40592.94NoYes078
18A:A:I223 A:A:L38 89.05934.28NoYes078
19A:A:I49 A:A:L38 93.15734.28NoYes078
20A:A:I49 A:A:N331 92.9784.25NoNo078
21A:A:N331 A:A:T324 93.06877.31NoYes089
22A:A:D328 A:A:T324 95.58585.78NoYes1399
23A:A:D328 A:A:K272 95.6112.77NoYes1395
24A:A:K272 A:A:Y297 96.21315.97YesNo053
25A:A:F275 A:A:Y297 96.39194.13NoNo083
26A:A:F275 A:A:L228 98.410415.83NoNo087
27A:A:L228 A:A:L269 1005.54NoYes078
28A:A:L269 A:A:V226 49.97674.47YesYes087
29A:A:F224 A:A:V226 25.01972.62YesYes097
30A:A:F224 A:A:F251 49.956511.79YesYes099
31A:A:F251 A:A:I265 99.74683.77YesYes296
32A:A:I222 A:A:I265 99.8352.94YesYes276
33A:A:I222 A:A:L37 76.96934.28YesYes279
34A:A:F216 A:A:L37 74.08613.65YesYes299
35A:A:F216 B:B:W99 30.52435.01YesYes299
36B:B:Q75 B:B:W99 30.92077.67NoYes099
37B:B:A56 B:B:Q75 31.26483.03NoNo079
38B:B:A56 B:B:D76 31.18044.63NoYes079
39R:R:R144 R:R:Y231 10.80758.23YesYes099
40A:A:I342 A:A:Y320 42.91217.25YesYes068
41A:A:I266 A:A:I342 43.22212.94YesYes086
42A:A:L267 A:A:L269 49.90784.15YesYes1698
43A:A:F224 A:A:L267 24.99153.65YesYes099
44A:A:F308 A:A:V226 25.0889.18YesYes087
45A:A:F251 A:A:F308 50.03938.57YesYes098
46A:A:F308 A:A:L267 25.05993.65YesYes089
47B:B:D76 B:B:K78 26.23865.53YesNo098
48A:A:F259 A:A:F260 19.74523.22YesNo049
49A:A:F259 A:A:H214 19.24949.05YesYes248
50A:A:C215 B:B:Y59 19.50235.38YesYes268
51B:B:W332 B:B:Y59 20.05083.86YesYes298
52B:B:M61 B:B:W63 11.80025.82NoYes367
53B:B:C317 B:B:M61 12.34956.48NoNo076
54B:B:C317 B:B:S316 12.89333.44NoNo079
55B:B:S316 B:B:W332 13.16654.94NoYes099
56A:A:F260 A:A:T263 19.80373.89NoNo098
57A:A:I222 A:A:T263 19.89283.04YesNo078
58B:B:H91 B:B:I81 23.71186.63YesYes057
59B:B:I81 B:B:Y105 23.0713.63YesYes1176
60B:B:H62 B:B:Y105 23.05294.36NoYes066
61B:B:H62 B:B:R150 22.947810.16NoNo066
62B:B:L192 B:B:R150 22.84263.64NoNo056
63B:B:F199 B:B:L192 22.3113.65YesNo095
64B:B:N313 B:B:W332 15.88047.91NoYes079
65B:B:D333 B:B:N313 15.30264.04YesNo097
66B:B:D333 B:B:H311 12.14675.04YesYes399
67B:B:R314 B:B:W332 29.405614.99NoYes089
68B:B:D290 B:B:R314 29.118219.06NoNo068
69B:B:C271 B:B:D290 28.54387.78NoNo056
70B:B:C271 B:B:D291 27.96986.22NoNo058
71B:B:D291 B:B:Y289 26.23996.9NoYes087
72B:B:W297 B:B:Y264 20.5199.65YesYes485
73R:R:I140 R:R:Y314 35.68094.84NoYes199
74R:R:N310 R:R:Y314 33.62144.65NoYes199
75R:R:D94 R:R:N310 33.40810.77YesNo199
76R:R:D94 R:R:H306 22.4816.3YesYes199
77R:R:F97 R:R:H306 12.74933.39YesYes169
78R:R:R159 R:R:V82 11.77563.92NoYes137
79R:R:V162 R:R:V82 11.33814.81NoYes077
80R:R:V162 R:R:V85 11.10658.02NoNo076
81R:R:N89 R:R:V85 10.8762.96NoNo096
82R:R:C166 R:R:Y86 11.24382.69NoYes077
83R:R:C166 R:R:N89 11.01239.45NoNo079
84R:R:N89 R:R:W170 21.43234.52NoYes099
85R:R:S132 R:R:W170 20.06669.88NoYes069
86R:R:S132 R:R:S173 19.15796.52NoNo067
87R:R:S173 R:R:Y131 10.97865.09NoYes077
88A:A:I19 A:A:L23 24.0962.85YesYes886
89B:B:W297 B:B:Y289 21.63359.65YesYes487
90A:A:C215 A:A:F216 38.86062.79YesYes269
91A:A:C215 A:A:H214 19.50272.95YesYes268
92A:A:H214 B:B:W332 38.49996.35YesYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8XXR
Class A
SubFamily Protein
Type Chemokine
SubType CXCR2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Go/Beta1/Gamma2
PDB Resolution 3.17
Date 2025-01-15
D.O.I. doi.org/10.1016/j.molcel.2025.01.024
Net Summary
Imin 2.62
Number of Linked Nodes 822
Number of Links 1023
Number of Hubs 185
Number of Links mediated by Hubs 647
Number of Communities 27
Number of Nodes involved in Communities 260
Number of Links involved in Communities 380
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 4468904
Length Of Smallest Path 3
Average Path Length 44.121
Length of Longest Path 81
Minimum Path Strength 1.225
Average Path Strength 5.70244
Maximum Path Strength 23.15
Minimum Path Correlation 0.7
Average Path Correlation 0.992743
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 31.7985
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.2306
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP09471
Sequence
>8XXR_Chain_A
TLSAEERAA LERSKAIEK NLKEDGISA AKDVKLLLL GASGKSTIV 
KQMKIITGI VETHFTFKN LHFRLFDVG GQRSERKKW IHCFEDVTA 
IIFCVLSHE SLMLFDSIC NNKFFIDTS IILFLNKKD LFGEKIKKS 
PLTICFPEY TGPNTYEDA AAYIQAQFE SKNRSPNKE IYCHMTCAT 
DTNNQVFDA VTDIIIANN LRGCGLYDN DAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8XXR_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8XXR_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP25025
Sequence
>8XXR_Chain_R
PCEPESLEI NKYFVVIIY ALVFLLSLL GNSLVMLVI LYSRVGRSV 
TDVYLLNLA LADLLFALT LPIWAASKV NGWIFGTFL CKVVSLLKE 
VNFYSGILL LACISVDRY LAIVHATRT LTQKRYLVK FICLSIWGL 
SLLLALPVL LFRRTVYSS NVSPACYED MGNNTANWR MLLRILPQS 
FGFIVPLLI MLFCYGFTL RTLFKAHMG QKHRAMRVI FAVVLIFLL 
CWLPYNLVL LADTLMRTQ VIQETCERR NHIDRALDA TEILGILHS 
CLNPLIYAF IGQKFRHGL LKILA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LFLAProteinChemokineCXCR2Homo sapiens-PubChem 153466996-3.22020-09-02doi.org/10.1038/s41586-020-2492-5
6LFMAProteinChemokineCXCR2Homo sapiensInterleukin-8-Gi1/β1/γ23.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFM (No Gprot) AProteinChemokineCXCR2Homo sapiensInterleukin-8-3.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFOAProteinChemokineCXCR2Homo sapiensInterleukin-8-Gi1/β1/γ23.42020-09-02doi.org/10.1038/s41586-020-2492-5
6LFO (No Gprot) AProteinChemokineCXCR2Homo sapiensInterleukin-8-3.42020-09-02doi.org/10.1038/s41586-020-2492-5
8XVUAProteinChemokineCXCR2Homo sapiensCXCL2--3.092025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWAAProteinChemokineCXCR2Homo sapiensCXCL1--3.482025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWFAProteinChemokineCXCR2Homo sapiensCXCL3--3.652025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWMAProteinChemokineCXCR2Homo sapiensCXCL6--3.712025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWNAProteinChemokineCXCR2Homo sapiensCXCL8--3.292025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWSAProteinChemokineCXCR2Homo sapiensCXCL5--3.062025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWVAProteinChemokineCXCR2Homo sapiensCXCL1-Go/β1/γ23.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWV (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL1-3.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3AProteinChemokineCXCR2Homo sapiensCXCL3-Go/β1/γ23.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL3-3.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6AProteinChemokineCXCR2Homo sapiensCXCL8-Go/β1/γ22.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL8-2.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7AProteinChemokineCXCR2Homo sapiensCXCL5-Go/β1/γ23.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL5-3.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXHAProteinChemokineCXCR2Homo sapiensCXCL2-Go/β1/γ22.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXH (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL2-2.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXRAProteinChemokineCXCR2Homo sapiens--Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXR (No Gprot) AProteinChemokineCXCR2Homo sapiens--3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXXAProteinChemokineCXCR2Homo sapiensCXCL6-Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXX (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL6-3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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