Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:K30 8.53410
2L:L:E31 6.655410
3L:L:L52 4.1175480
4L:L:E56 3.4225400
5L:L:W84 9.472530
6L:L:V85 4.972530
7L:L:V88 4.195430
8N:N:C36 6.4375440
9N:N:K42 6.7225400
10N:N:R53 6.3175400
11N:N:V54 3.3275480
12N:N:E56 4.7025400
13N:N:N63 7.105490
14N:N:K69 6.5775400
15N:N:E75 5.56440
16N:N:D79 5.24754100
17N:N:P80 5.86254100
18R:R:F32 3.34403
19R:R:V69 3.8875408
20R:R:V82 7.92254127
21R:R:Y86 6.2925407
22R:R:L90 5.412529
23R:R:W112 7.0125409
24R:R:E127 6.326554
25R:R:N129 6.145408
26R:R:F130 9.4875457
27R:R:Y131 7.12333657
28R:R:D143 7.60754128
29R:R:Y145 6.145408
30R:R:V162 5.8375407
31R:R:N191 9.2275462
32R:R:Y197 8.4375413
33R:R:R212 8.425415
34R:R:F220 6.3925408
35R:R:P223 3.485409
36R:R:Y231 8.17529
37R:R:V256 4.0775408
38R:R:W264 8.42508
39R:R:Y267 4.95607
40R:R:T275 4.225414
41R:R:M277 3.7375404
42R:R:R278 7.674514
43R:R:L296 4.775415
44R:R:E300 4.7225405
45R:R:N310 6.458529
46R:R:Y314 6.07167629
47R:R:F321 3.93408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:E31 L:L:K30 12.1113.5YesYes100
2L:L:K30 R:R:E300 12.39779.45YesYes005
3L:L:E31 R:R:Y197 89.41564.49YesYes103
4R:R:R208 R:R:R278 11.15617.46NoYes144
5R:R:R278 R:R:R289 14.400311.73YesNo043
6L:L:H60 L:L:P59 25.07563.05NoNo000
7L:L:P59 R:R:V187 92.17538.84NoNo003
8R:R:V187 R:R:Y197 92.40185.05NoYes033
9L:L:P80 L:L:T64 48.29533.5NoNo000
10L:L:S57 L:L:T64 49.46461.6NoNo000
11L:L:E56 L:L:S57 55.19942.87YesNo000
12L:L:E56 L:L:G58 82.74723.27YesNo000
13L:L:G58 L:L:P59 83.08494.06NoNo000
14L:L:P80 L:L:Q86 41.22423.16NoNo000
15L:L:Q86 N:N:E97 40.63966.37NoNo000
16L:L:V89 N:N:E97 39.50742.85NoNo000
17L:L:V85 L:L:V89 22.18221.6YesNo300
18L:L:V85 L:L:W84 10.22819.81YesYes300
19L:L:V88 L:L:V89 16.77591.6YesNo300
20L:L:V88 L:L:W84 10.29864.9YesYes300
21L:L:F44 L:L:W84 11.6725.01NoYes000
22L:L:F44 L:L:Y40 10.99834.13NoNo000
23L:L:L78 L:L:V85 12.54255.96NoYes000
24L:L:L76 L:L:L78 11.16534.15NoNo000
25L:L:L76 L:L:V68 10.10935.96NoNo000
26L:L:H60 L:L:I55 22.8042.65NoNo000
27L:L:I55 L:L:R53 22.03933.76NoNo000
28L:L:R53 N:N:R53 15.795912.79NoYes000
29N:N:I67 N:N:R53 13.39062.51NoYes000
30N:N:E75 N:N:I67 12.58145.47YesNo000
31L:L:E56 N:N:F92 26.94833.5YesNo000
32N:N:F92 N:N:I49 25.563718.84NoNo000
33N:N:I49 N:N:V68 24.95133.07NoNo000
34N:N:L78 N:N:V68 19.85675.96NoNo000
35N:N:I66 N:N:L78 16.03165.71NoNo000
36N:N:I66 N:N:V54 11.77043.07NoYes000
37L:L:E56 N:N:K50 14.06064.05YesNo000
38R:R:E300 R:R:Y55 14.98493.37YesNo057
39L:L:E31 R:R:L296 79.12813.98YesYes105
40R:R:L296 R:R:Y267 80.18973.52YesYes057
41R:R:W264 R:R:Y267 1004.82YesYes087
42R:R:H306 R:R:W264 62.116513.75NoYes098
43R:R:H306 R:R:N310 60.90275.1NoYes099
44R:R:N310 R:R:P311 28.31613.26YesNo099
45R:R:P311 R:R:V69 24.59493.53NoYes098
46R:R:F316 R:R:V69 21.38795.24NoYes068
47R:R:F316 R:R:F321 18.12144.29NoYes068
48R:R:N310 R:R:Y314 37.04833.49YesYes299
49R:R:I140 R:R:Y314 15.96116.04NoYes299
50R:R:I140 R:R:Y86 16.57914.84NoYes097
51R:R:D143 R:R:Y86 10.046210.34YesYes087
52R:R:F130 R:R:W264 52.094412.03YesYes078
53R:R:E127 R:R:F130 41.77918.16YesYes547
54R:R:E127 R:R:V180 39.75244.28YesNo044
55R:R:S123 R:R:V180 25.1353.23NoNo054
56R:R:S123 R:R:W104 14.00683.71NoNo056
57R:R:K126 R:R:W104 13.212512.76NoNo066
58R:R:R184 R:R:S123 11.538413.18NoNo055
59R:R:C196 R:R:R184 20.868211.14NoNo095
60R:R:C119 R:R:C196 19.28517.28NoNo099
61R:R:C119 R:R:W112 17.69837.84NoYes099
62R:R:E198 R:R:V180 14.19618.56NoNo054
63R:R:E198 R:R:R184 11.174616.28NoNo055
64R:R:I134 R:R:W264 23.72825.87NoYes088
65R:R:F260 R:R:I134 18.62076.28NoNo098
66R:R:F260 R:R:M227 18.27737.46NoNo098
67R:R:M227 R:R:S141 16.49754.6NoNo089
68R:R:C230 R:R:S141 10.39145.16NoNo279
69R:R:V256 R:R:Y314 14.85875.05YesYes089
70R:R:C230 R:R:Y145 13.8625.38NoYes078
71R:R:R212 R:R:R278 10.30423.2YesYes154
72R:R:L271 R:R:Y267 12.37544.69NoYes067
73R:R:I253 R:R:Y231 10.85547.25NoYes079
74R:R:E300 R:R:Y267 14.17383.37YesYes057
75R:R:L271 R:R:R212 11.948610.93NoYes065
76R:R:R208 R:R:Y197 10.170611.32NoYes143
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K30 R:R:D293 5.53 1 Yes No 0 4 0 1
L:L:K30 R:R:L296 5.64 1 Yes Yes 0 5 0 1
L:L:K30 R:R:E300 9.45 1 Yes Yes 0 5 0 1
L:L:E31 R:R:Y197 4.49 1 Yes Yes 0 3 0 1
L:L:E31 R:R:R208 4.65 1 Yes No 0 4 0 1
L:L:E31 R:R:L296 3.98 1 Yes Yes 0 5 0 1
L:L:L32 R:R:S189 4.5 0 No No 0 1 0 1
L:L:L32 R:R:V192 4.47 0 No No 0 5 0 1
L:L:L32 R:R:Y197 12.89 0 No Yes 0 3 0 1
L:L:R33 R:R:R289 27.72 0 No No 0 3 0 1
L:L:Q35 R:R:E40 3.82 6 No No 0 4 0 1
L:L:Q35 R:R:N191 13.2 6 No Yes 0 2 0 1
L:L:Y40 R:R:L34 3.52 0 No No 0 2 0 1
L:L:H45 R:R:T28 5.48 0 No No 0 7 0 1
L:L:F48 R:R:F32 3.22 0 No Yes 0 3 0 1
L:L:P59 R:R:V187 8.84 0 No No 0 3 0 1
L:L:I67 R:R:P38 3.39 0 No No 0 7 0 1
L:L:D72 R:R:F32 3.58 0 No Yes 0 3 0 1
L:L:R74 R:R:F32 5.34 0 No Yes 0 3 0 1
L:L:E75 R:R:A37 4.53 0 No No 0 7 0 1
L:L:E75 R:R:P38 7.86 0 No No 0 7 0 1
N:N:E51 R:R:S190 5.75 0 No No 0 2 0 1
N:N:K69 R:R:Y188 5.97 0 Yes No 0 1 0 1
R:R:L29 R:R:P31 11.49 0 No No 3 5 1 2
R:R:C286 R:R:C39 7.28 0 No No 6 8 1 2
R:R:E40 R:R:N191 11.83 6 No Yes 4 2 1 1
R:R:E300 R:R:Y55 3.37 0 Yes No 5 7 1 2
R:R:V187 R:R:Y197 5.05 0 No Yes 3 3 1 1
R:R:P194 R:R:Y188 9.74 0 No No 5 1 2 1
R:R:N191 R:R:S190 7.45 6 Yes No 2 2 1 1
R:R:N191 R:R:V192 4.43 6 Yes No 2 5 1 1
R:R:R208 R:R:Y197 11.32 1 No Yes 4 3 1 1
R:R:N202 R:R:N203 5.45 0 No No 2 4 1 2
R:R:R208 R:R:R278 7.46 1 No Yes 4 4 1 2
R:R:L296 R:R:Y267 3.52 1 Yes Yes 5 7 1 2
R:R:E300 R:R:Y267 3.37 0 Yes Yes 5 7 1 2
R:R:L296 R:R:V270 5.96 1 Yes No 5 4 1 2
R:R:M277 R:R:R289 3.72 0 Yes No 4 3 2 1
R:R:R278 R:R:R289 11.73 1 Yes No 4 3 2 1
L:L:K42 R:R:L29 2.82 0 No No 0 3 0 1
R:R:E300 R:R:K108 2.7 0 Yes No 5 5 1 2
R:R:E284 R:R:Q283 2.55 0 No No 3 2 1 2
L:L:A29 R:R:V192 1.7 0 No No 0 5 0 1
R:R:G201 R:R:N202 1.7 0 No No 4 2 2 1
L:L:K38 R:R:A36 1.61 0 No No 0 5 0 1
R:R:A36 R:R:L34 1.58 0 No No 5 2 1 1
L:L:S57 R:R:N202 1.49 0 No No 0 2 0 1
L:L:R33 R:R:C286 1.39 0 No No 0 6 0 1
L:L:I37 R:R:E284 1.37 0 No No 0 3 0 1
R:R:F32 R:R:L33 1.22 0 Yes No 3 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6LFM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.02
Number of Linked Nodes 422
Number of Links 458
Number of Hubs 47
Number of Links mediated by Hubs 172
Number of Communities 13
Number of Nodes involved in Communities 55
Number of Links involved in Communities 66
Path Summary
Number Of Nodes in MetaPath 77
Number Of Links MetaPath 76
Number of Shortest Paths 108977
Length Of Smallest Path 3
Average Path Length 16.7451
Length of Longest Path 38
Minimum Path Strength 1.405
Average Path Strength 5.75683
Maximum Path Strength 19.725
Minimum Path Correlation 0.7
Average Path Correlation 0.958863
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 58.5154
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.3895
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular function activator activity   • signaling receptor binding   • G protein-coupled receptor binding   • signaling receptor activator activity   • cytokine receptor binding   • chemokine activity   • molecular function regulator activity   • cytokine activity   • signaling receptor regulator activity   • chemokine receptor binding   • receptor ligand activity   • CXCR chemokine receptor binding   • heparin binding   • glycosaminoglycan binding   • carbohydrate derivative binding   • sulfur compound binding   • interleukin-8 receptor binding   • cell adhesion   • regulation of cell adhesion   • positive chemotaxis   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of positive chemotaxis   • positive regulation of biological process   • response to external stimulus   • induction of positive chemotaxis   • regulation of chemotaxis   • positive regulation of chemotaxis   • positive regulation of response to stimulus   • regulation of positive chemotaxis   • positive regulation of response to external stimulus   • taxis   • regulation of response to stimulus   • regulation of locomotion   • locomotion   • localization   • import into cell   • receptor internalization   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • developmental process   • multicellular organismal process   • blood vessel morphogenesis   • tube development   • angiogenesis   • vasculature development   • circulatory system development   • anatomical structure morphogenesis   • multicellular organism development   • tube morphogenesis   • anatomical structure formation involved in morphogenesis   • anatomical structure development   • blood vessel development   • system development   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • digestive system development   • animal organ development   • embryo development   • digestive tract development   • embryonic organ development   • embryonic digestive tract development   • neutrophil activation   • immune system process   • cell activation   • myeloid leukocyte activation   • granulocyte activation   • leukocyte activation   • cell chemotaxis   • neutrophil chemotaxis   • neutrophil migration   • granulocyte migration   • leukocyte migration   • granulocyte chemotaxis   • myeloid leukocyte migration   • cell migration   • cell motility   • leukocyte chemotaxis   • biological process involved in interspecies interaction between organisms   • entry of bacterium into host cell   • regulation of entry of bacterium into host cell   • symbiont entry into host   • modulation by symbiont of entry into host   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • regulation of biological process involved in symbiotic interaction   • response to other organism   • cellular response to lipopolysaccharide   • cellular response to molecule of bacterial origin   • response to lipopolysaccharide   • response to biotic stimulus   • cellular response to biotic stimulus   • response to bacterium   • response to external biotic stimulus   • response to molecule of bacterial origin   • regulation of cell motility   • positive regulation of cell migration   • positive regulation of neutrophil chemotaxis   • regulation of immune system process   • positive regulation of immune system process   • regulation of leukocyte chemotaxis   • regulation of leukocyte migration   • positive regulation of leukocyte chemotaxis   • positive regulation of granulocyte chemotaxis   • regulation of neutrophil chemotaxis   • regulation of neutrophil migration   • regulation of granulocyte chemotaxis   • positive regulation of cell motility   • regulation of cell migration   • positive regulation of leukocyte migration   • positive regulation of neutrophil migration   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • response to fibroblast growth factor   • cellular response to growth factor stimulus   • response to growth factor   • cellular response to fibroblast growth factor stimulus   • regulation of cell adhesion molecule production   • negative regulation of cellular process   • negative regulation of biological process   • negative regulation of cell adhesion molecule production   • cell adhesion molecule production   • response to peptide   • cellular response to tumor necrosis factor   • response to cytokine   • cellular response to cytokine stimulus   • response to tumor necrosis factor   • negative regulation of cell population proliferation   • regulation of cell population proliferation   • regulation of developmental process   • regulation of vasculature development   • positive regulation of developmental process   • regulation of multicellular organismal process   • regulation of anatomical structure morphogenesis   • regulation of multicellular organismal development   • positive regulation of angiogenesis   • positive regulation of vasculature development   • regulation of angiogenesis   • positive regulation of multicellular organismal process   • humoral immune response   • defense response   • immune response   • defense response to symbiont   • antimicrobial humoral response   • antimicrobial humoral immune response mediated by antimicrobial peptide   • defense response to other organism   • response to stress   • inflammatory response   • regulation of signaling   • negative regulation of signaling   • negative regulation of response to stimulus   • regulation of signal transduction   • negative regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • regulation of cell communication   • regulation of G protein-coupled receptor signaling pathway   • regulation of single stranded viral RNA replication via double stranded DNA intermediate   • RNA metabolic process   • viral life cycle   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • regulation of RNA metabolic process   • viral RNA genome replication   • viral process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • primary metabolic process   • nucleobase-containing compound biosynthetic process   • single stranded viral RNA replication via double stranded DNA intermediate   • nucleic acid metabolic process   • regulation of viral life cycle   • regulation of viral process   • viral genome replication   • regulation of viral genome replication   • negative regulation of metabolic process   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of macromolecule metabolic process   • cellular response to interleukin-1   • response to interleukin-1   • cellular response to stress   • response to endoplasmic reticulum stress   • G protein-coupled chemoattractant receptor activity   • molecular transducer activity   • interleukin-8 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • C-C chemokine receptor activity   • chemokine binding   • C-X-C chemokine binding   • interleukin-8 binding   • cytokine binding   • C-C chemokine binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • positive regulation of cell population proliferation   • dendritic cell chemotaxis   • dendritic cell migration   • mononuclear cell migration   • cell surface receptor signaling pathway   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular defense response   • cytokine-mediated signaling pathway   • cellular response to interleukin-8   • response to interleukin-8   • interleukin-8-mediated signaling pathway   • cell surface   • external side of plasma membrane   • mast cell granule   • mitotic spindle   • cytoskeleton   • spindle   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • intracellular vesicle   • endomembrane system   • cytoplasmic vesicle membrane   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • secretory granule membrane   • D2 dopamine receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • lymphocyte migration   • T cell migration   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of protein localization   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleolus   • cell cortex   • centrosome   • microtubule organizing center   • centriolar satellite   • Golgi apparatus   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Interleukin 8-like chemokines   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Interleukin 8-like chemokines   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP25025
Sequence
>6LFM_nogp_Chain_R
SSTLPPFLL DAAPCEPES LEINKYFVV IIYALVFLL SLLGNSLVM 
LVILYSRVG RSVTDVYLL NLALADLLF ALTLPIWAA SKVNGWIFG 
TFLCKVVSL LKEVNFYSG ILLLACISV DRYLAIVHA TRTLTQKRY 
LVKFICLSI WGLSLLLAL PVLLFRRTV YSSNVSPAC YEDMGNNTA 
NWRMLLRIL PQSFGFIVP LLIMLFCYG FTLRTLFKA HMGQKHRAM 
RVIFAVVLI FLLCWLPYN LVLLADTLM RTQVIQETC ERRNHIDRA 
LDATEILGI LHSCLNPLI YAFIGQKFR HGLLKILAI H


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LFLAProteinChemokineCXCR2Homo sapiens-PubChem 153466996-3.22020-09-02doi.org/10.1038/s41586-020-2492-5
6LFMAProteinChemokineCXCR2Homo sapiensInterleukin-8-Gi1/β1/γ23.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFM (No Gprot) AProteinChemokineCXCR2Homo sapiensInterleukin-8-3.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFOAProteinChemokineCXCR2Homo sapiensInterleukin-8-Gi1/β1/γ23.42020-09-02doi.org/10.1038/s41586-020-2492-5
6LFO (No Gprot) AProteinChemokineCXCR2Homo sapiensInterleukin-8-3.42020-09-02doi.org/10.1038/s41586-020-2492-5
8XVUAProteinChemokineCXCR2Homo sapiensCXCL2--3.092025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWAAProteinChemokineCXCR2Homo sapiensCXCL1--3.482025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWFAProteinChemokineCXCR2Homo sapiensCXCL3--3.652025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWMAProteinChemokineCXCR2Homo sapiensCXCL6--3.712025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWNAProteinChemokineCXCR2Homo sapiensCXCL8--3.292025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWSAProteinChemokineCXCR2Homo sapiensCXCL5--3.062025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWVAProteinChemokineCXCR2Homo sapiensCXCL1-Go/β1/γ23.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWV (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL1-3.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3AProteinChemokineCXCR2Homo sapiensCXCL3-Go/β1/γ23.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL3-3.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6AProteinChemokineCXCR2Homo sapiensCXCL8-Go/β1/γ22.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL8-2.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7AProteinChemokineCXCR2Homo sapiensCXCL5-Go/β1/γ23.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL5-3.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXHAProteinChemokineCXCR2Homo sapiensCXCL2-Go/β1/γ22.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXH (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL2-2.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXRAProteinChemokineCXCR2Homo sapiens--Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXR (No Gprot) AProteinChemokineCXCR2Homo sapiens--3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXXAProteinChemokineCXCR2Homo sapiensCXCL6-Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXX (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL6-3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024




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