psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E10	R:R:R208	9.3	Yes	Yes	1	0	4
2	L:L:E10	R:R:R212	4.65	Yes	Yes	1	0	5
3	L:L:E10	R:R:D274	6.5	Yes	Yes	1	0	4
4	L:L:E10	R:R:R278	8.14	Yes	Yes	1	0	4
5	L:L:E10	R:R:L296	6.63	Yes	No	0	0	5
6	L:L:L11	L:L:Q38	2.66	No	No	1	0	0
7	L:L:L11	R:R:V187	2.98	No	No	1	0	3
8	L:L:L11	R:R:Y197	11.72	No	Yes	1	0	3
9	L:L:R12	R:R:D274	11.91	Yes	Yes	1	0	4
10	L:L:R12	R:R:M277	3.72	Yes	Yes	1	0	4
11	L:L:R12	R:R:R278	6.4	Yes	Yes	1	0	4
12	L:L:R12	R:R:R289	9.6	Yes	Yes	1	0	3
13	L:L:R12	R:R:I292	2.51	Yes	Yes	1	0	5
14	L:L:R12	R:R:D293	10.72	Yes	No	0	0	4
15	L:L:C13	L:L:C39	7.28	No	No	3	0	0
16	L:L:E43	L:L:V14	8.56	Yes	No	0	0	0
17	L:L:V14	R:R:N191	4.43	No	No	0	0	2
18	L:L:C15	L:L:E43	4.56	No	Yes	0	0	0
19	L:L:C15	L:L:C55	7.28	No	No	0	0	0
20	L:L:L16	R:R:E284	6.63	No	Yes	1	0	3
21	L:L:L16	R:R:R289	8.5	No	Yes	1	0	3
22	L:L:Q17	R:R:D35	10.44	No	No	0	0	6
23	L:L:I54	L:L:T19	3.04	No	Yes	6	0	0
24	L:L:T19	R:R:L33	2.95	Yes	No	6	0	3
25	L:L:T19	R:R:A36	3.36	Yes	No	0	0	5
26	L:L:H23	L:L:P24	7.63	No	No	0	0	0
27	L:L:H23	L:L:K25	9.17	No	No	0	0	0
28	L:L:K69	L:L:P24	3.35	No	No	0	0	0
29	L:L:K25	L:L:M26	4.32	No	No	0	0	0
30	L:L:M26	L:L:N50	4.21	No	No	0	0	0
31	L:L:I27	L:L:L30	2.85	No	No	0	0	0
32	L:L:I27	L:L:L48	2.85	No	No	0	0	0
33	L:L:N29	L:L:S28	7.45	No	No	0	0	0
34	L:L:N29	L:L:S47	2.98	No	No	0	0	0
35	L:L:N29	N:N:F33	12.08	No	No	0	0	0
36	L:L:I70	L:L:L30	2.85	No	No	0	0	0
37	L:L:F33	L:L:Q31	12.88	Yes	No	3	0	0
38	L:L:Q31	N:N:Q31	12.8	No	No	0	0	0
39	L:L:Q31	R:R:S190	2.89	No	No	3	0	2
40	L:L:V32	L:L:V44	4.81	No	Yes	0	0	0
41	L:L:E43	L:L:F33	7	Yes	Yes	3	0	0
42	L:L:F33	N:N:N29	12.08	Yes	Yes	3	0	0
43	L:L:F33	R:R:S190	2.64	Yes	No	3	0	2
44	L:L:A34	N:N:I70	3.25	No	No	0	0	0
45	L:L:I35	L:L:V42	3.07	Yes	No	0	0	0
46	L:L:I35	R:R:N202	5.66	Yes	No	0	0	2
47	L:L:G36	L:L:P37	4.06	No	No	0	0	0
48	L:L:P37	R:R:Y197	2.78	No	Yes	0	0	3
49	L:L:P37	R:R:D199	6.44	No	No	0	0	4
50	L:L:Q38	R:R:V187	2.87	No	No	1	0	3
51	L:L:Q38	R:R:S189	5.78	No	No	0	0	1
52	L:L:P58	L:L:V42	3.53	No	No	0	0	0
53	L:L:L56	L:L:V44	2.98	Yes	Yes	7	0	0
54	L:L:L63	L:L:V44	8.94	Yes	Yes	7	0	0
55	L:L:A46	L:L:L56	4.73	No	Yes	0	0	0
56	L:L:E53	L:L:S47	5.75	No	No	0	0	0
57	L:L:I54	L:L:L48	4.28	No	No	0	0	0
58	L:L:E53	R:R:P38	7.86	No	Yes	0	0	7
59	L:L:I54	R:R:L33	4.28	No	No	6	0	3
60	L:L:C55	R:R:P38	5.65	No	Yes	0	0	7
61	L:L:F62	L:L:L56	3.65	No	Yes	0	0	0
62	L:L:L56	L:L:L63	2.77	Yes	Yes	7	0	0
63	L:L:D57	L:L:P58	4.83	No	No	0	0	0
64	L:L:D57	L:L:E59	2.6	No	No	0	0	0
65	L:L:A60	L:L:D57	4.63	No	No	0	0	0
66	L:L:F62	L:L:V66	9.18	No	No	0	0	0
67	L:L:I67	L:L:L63	4.28	No	Yes	0	0	0
68	L:L:L63	N:N:L71	4.15	Yes	No	0	0	0
69	L:L:I70	L:L:V66	3.07	No	No	0	0	0
70	L:L:I67	L:L:L71	2.85	No	No	0	0	0
71	L:L:I67	N:N:I67	2.94	No	No	0	0	0
72	L:L:I70	N:N:A34	3.25	No	No	0	0	0
73	L:L:L71	N:N:L63	4.15	No	Yes	0	0	0
74	N:N:L11	N:N:Q38	2.66	No	No	0	0	0
75	N:N:C13	N:N:C39	7.28	No	No	4	0	0
76	N:N:E43	N:N:V14	8.56	Yes	No	0	0	0
77	N:N:C15	N:N:E43	4.56	No	Yes	4	0	0
78	N:N:C15	N:N:C55	7.28	No	No	4	0	0
79	N:N:I54	N:N:T19	3.04	No	No	0	0	0
80	N:N:H23	N:N:P24	7.63	No	No	0	0	0
81	N:N:H23	N:N:K25	6.55	No	No	0	0	0
82	N:N:K69	N:N:P24	3.35	No	No	0	0	0
83	N:N:M26	N:N:N50	4.21	No	No	0	0	0
84	N:N:I27	N:N:L30	2.85	No	No	0	0	0
85	N:N:I27	N:N:L48	2.85	No	No	0	0	0
86	N:N:N29	N:N:S28	7.45	Yes	No	0	0	0
87	N:N:N29	N:N:S47	2.98	Yes	No	0	0	0
88	N:N:N29	R:R:S190	4.47	Yes	No	3	0	2
89	N:N:I70	N:N:L30	2.85	No	No	0	0	0
90	N:N:F33	N:N:Q31	12.88	No	No	0	0	0
91	N:N:V32	N:N:V44	4.81	No	Yes	0	0	0
92	N:N:E43	N:N:F33	7	Yes	No	0	0	0
93	N:N:I35	N:N:V42	3.07	No	No	0	0	0
94	N:N:G36	N:N:P37	4.06	No	No	0	0	0
95	N:N:P58	N:N:V42	3.53	No	No	0	0	0
96	N:N:L56	N:N:V44	2.98	Yes	Yes	8	0	0
97	N:N:L63	N:N:V44	8.94	Yes	Yes	8	0	0
98	N:N:A46	N:N:L56	4.73	No	Yes	0	0	0
99	N:N:E53	N:N:S47	5.75	No	No	0	0	0
100	N:N:I54	N:N:L48	4.28	No	No	0	0	0
101	N:N:K49	R:R:R185	3.71	No	No	0	0	4
102	N:N:G51	R:R:Y188	10.14	No	No	0	0	1
103	N:N:F62	N:N:L56	3.65	No	Yes	0	0	0
104	N:N:L56	N:N:L63	2.77	Yes	Yes	8	0	0
105	N:N:D57	N:N:P58	4.83	No	No	0	0	0
106	N:N:A60	N:N:D57	4.63	No	No	0	0	0
107	N:N:F62	N:N:V66	9.18	No	No	0	0	0
108	N:N:I67	N:N:L63	4.28	No	Yes	0	0	0
109	N:N:I70	N:N:V66	3.07	No	No	0	0	0
110	N:N:I67	N:N:L71	2.85	No	No	0	0	0
111	R:R:C286	R:R:C39	7.28	No	No	0	6	8
112	R:R:C39	R:R:R289	2.79	No	Yes	0	8	3
113	R:R:E40	R:R:P41	3.14	No	No	0	4	4
114	R:R:N191	R:R:P41	9.77	No	No	0	2	4
115	R:R:P41	R:R:V192	3.53	No	No	0	4	5
116	R:R:E42	R:R:L44	10.6	No	No	5	4	2
117	R:R:E42	R:R:N290	7.89	No	No	5	4	3
118	R:R:E42	R:R:R294	5.82	No	No	5	4	2
119	R:R:L44	R:R:N47	4.12	No	No	0	2	4
120	R:R:L44	R:R:R294	3.64	No	No	5	2	2
121	R:R:I46	R:R:N47	5.66	No	No	0	5	4
122	R:R:F50	R:R:I46	10.05	No	No	0	5	5
123	R:R:K48	R:R:V52	6.07	No	No	0	4	5
124	R:R:K48	R:R:V109	15.18	No	No	0	4	4
125	R:R:I53	R:R:Y49	15.71	No	No	0	5	2
126	R:R:V51	R:R:Y55	3.79	No	No	0	5	7
127	R:R:D297	R:R:V51	4.38	No	No	0	4	5
128	R:R:A105	R:R:Y55	4	No	No	0	7	7
129	R:R:I304	R:R:Y55	4.84	Yes	No	0	7	7
130	R:R:L57	R:R:L61	6.92	No	No	0	5	5
131	R:R:I304	R:R:V58	3.07	Yes	No	0	7	7
132	R:R:C308	R:R:V58	5.12	No	No	0	7	7
133	R:R:A98	R:R:F59	2.77	No	No	0	5	7
134	R:R:F59	R:R:P102	11.56	No	No	0	7	9
135	R:R:C308	R:R:L61	3.17	No	No	0	7	5
136	R:R:S307	R:R:S62	6.52	Yes	No	0	8	8
137	R:R:C308	R:R:S62	5.16	No	No	0	7	8
138	R:R:L63	R:R:S67	3	No	No	0	5	3
139	R:R:L64	R:R:L68	4.15	No	No	0	4	6
140	R:R:A91	R:R:N66	4.69	No	Yes	0	8	9
141	R:R:D94	R:R:N66	6.73	Yes	Yes	0	9	9
142	R:R:L95	R:R:N66	4.12	No	Yes	0	7	9
143	R:R:N66	R:R:P311	3.26	Yes	No	0	9	9
144	R:R:F316	R:R:L68	2.44	Yes	No	0	6	6
145	R:R:I73	R:R:V69	3.07	No	No	0	6	8
146	R:R:A91	R:R:V69	3.39	No	No	0	8	8
147	R:R:F316	R:R:V69	2.62	Yes	No	0	6	8
148	R:R:L92	R:R:M70	4.24	No	No	0	6	6
149	R:R:I328	R:R:L71	2.85	No	No	0	5	3
150	R:R:L325	R:R:V72	4.47	No	No	0	6	7
151	R:R:I73	R:R:L88	4.28	No	No	0	6	5
152	R:R:F321	R:R:I73	5.02	Yes	No	0	8	6
153	R:R:L74	R:R:R80	3.64	No	No	0	2	7
154	R:R:L74	R:R:L88	5.54	No	No	0	2	5
155	R:R:I328	R:R:Y75	12.09	No	No	0	5	4
156	R:R:R77	R:R:R80	6.4	No	No	0	6	7
157	R:R:D84	R:R:S81	5.89	No	No	0	8	7
158	R:R:D143	R:R:V82	5.84	No	No	10	8	7
159	R:R:R159	R:R:V82	3.92	Yes	No	10	3	7
160	R:R:V162	R:R:V82	3.21	No	No	0	7	7
161	R:R:L87	R:R:T83	2.95	No	No	0	7	7
162	R:R:V162	R:R:V85	8.02	No	No	0	7	6
163	R:R:C139	R:R:Y86	4.03	No	Yes	0	5	7
164	R:R:I140	R:R:Y86	6.04	No	Yes	0	9	7
165	R:R:D143	R:R:Y86	4.6	No	Yes	0	8	7
166	R:R:V162	R:R:Y86	8.83	No	Yes	0	7	7
167	R:R:I165	R:R:Y86	3.63	No	Yes	0	5	7
168	R:R:C166	R:R:Y86	2.69	No	Yes	0	7	7
169	R:R:A315	R:R:L87	3.15	No	No	9	7	7
170	R:R:F321	R:R:L87	3.65	Yes	No	9	8	7
171	R:R:C166	R:R:N89	7.87	No	No	0	7	9
172	R:R:N89	R:R:W170	3.39	No	Yes	0	9	9
173	R:R:D94	R:R:L90	4.07	Yes	Yes	2	9	9
174	R:R:L136	R:R:L90	2.77	No	Yes	0	8	9
175	R:R:L137	R:R:L90	4.15	No	Yes	0	8	9
176	R:R:L90	R:R:N310	5.49	Yes	Yes	2	9	9
177	R:R:A93	R:R:N129	4.69	No	No	0	8	8
178	R:R:A93	R:R:W170	2.59	No	Yes	0	8	9
179	R:R:D94	R:R:H306	3.78	Yes	Yes	2	9	9
180	R:R:D94	R:R:S307	2.94	Yes	Yes	2	9	8
181	R:R:D94	R:R:N310	6.73	Yes	Yes	2	9	9
182	R:R:L96	R:R:N129	12.36	No	No	0	7	8
183	R:R:F97	R:R:L101	7.31	Yes	No	2	6	8
184	R:R:F97	R:R:K126	7.44	Yes	No	0	6	6
185	R:R:F97	R:R:I304	5.02	Yes	Yes	2	6	7
186	R:R:F97	R:R:H306	3.39	Yes	Yes	2	6	9
187	R:R:F97	R:R:S307	2.64	Yes	Yes	2	6	8
188	R:R:T100	R:R:V122	3.17	No	No	0	7	5
189	R:R:L125	R:R:T100	4.42	No	No	0	4	7
190	R:R:I304	R:R:L101	5.71	Yes	No	2	7	8
191	R:R:I103	R:R:W112	3.52	No	Yes	1	6	9
192	R:R:F114	R:R:I103	2.51	Yes	No	1	6	6
193	R:R:V122	R:R:W104	2.45	No	No	0	5	6
194	R:R:S123	R:R:W104	2.47	No	No	0	5	6
195	R:R:K126	R:R:W104	6.96	No	No	0	6	6
196	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
197	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
198	R:R:D297	R:R:K108	2.77	No	No	0	4	5
199	R:R:E300	R:R:K108	4.05	No	No	0	5	5
200	R:R:G111	R:R:S193	3.71	No	No	0	4	3
201	R:R:F114	R:R:W112	3.01	Yes	Yes	1	6	9
202	R:R:G115	R:R:W112	2.81	No	Yes	0	8	9
203	R:R:C119	R:R:W112	6.53	No	Yes	1	9	9
204	R:R:V122	R:R:W112	2.45	No	Yes	0	5	9
205	R:R:C196	R:R:W112	6.53	No	Yes	1	9	9
206	R:R:I113	R:R:P194	3.39	No	No	0	3	5
207	R:R:F114	R:R:L118	2.44	Yes	No	0	6	6
208	R:R:K120	R:R:T116	4.5	No	No	0	7	3
209	R:R:R185	R:R:T116	2.59	No	No	0	4	3
210	R:R:T116	R:R:T186	6.28	No	No	0	3	4
211	R:R:F117	R:R:V121	6.55	No	No	0	1	5
212	R:R:C119	R:R:R184	2.79	No	Yes	1	9	5
213	R:R:C119	R:R:C196	7.28	No	No	1	9	9
214	R:R:S123	R:R:V180	3.23	No	No	1	5	4
215	R:R:R184	R:R:S123	11.86	Yes	No	1	5	5
216	R:R:L124	R:R:V128	2.98	No	No	0	6	5
217	R:R:L124	R:R:L181	4.15	No	No	0	6	5
218	R:R:L125	R:R:N129	4.12	No	No	0	4	8
219	R:R:E127	R:R:Y131	8.98	No	Yes	0	4	7
220	R:R:A177	R:R:E127	6.03	No	No	0	7	4
221	R:R:E127	R:R:V180	8.56	No	No	0	4	4
222	R:R:V128	R:R:W170	2.45	No	Yes	0	5	9
223	R:R:F130	R:R:Y131	7.22	No	Yes	0	7	7
224	R:R:F130	R:R:I134	6.28	No	Yes	2	7	8
225	R:R:F130	R:R:W264	11.02	No	Yes	2	7	8
226	R:R:S173	R:R:Y131	2.54	No	Yes	0	7	7
227	R:R:L176	R:R:Y131	3.52	No	Yes	0	4	7
228	R:R:P215	R:R:Y131	6.95	No	Yes	0	5	7
229	R:R:S132	R:R:W170	12.36	No	Yes	0	6	9
230	R:R:S132	R:R:S173	6.52	No	No	0	6	7
231	R:R:I134	R:R:P223	3.39	Yes	Yes	0	8	9
232	R:R:F260	R:R:I134	3.77	Yes	Yes	2	9	8
233	R:R:I134	R:R:W264	4.7	Yes	Yes	2	8	8
234	R:R:I169	R:R:L135	7.14	No	No	0	6	6
235	R:R:L135	R:R:L172	2.77	No	No	0	6	4
236	R:R:I169	R:R:L136	4.28	No	No	0	6	8
237	R:R:L137	R:R:Y314	12.89	No	Yes	0	8	9
238	R:R:C139	R:R:I169	3.27	No	No	0	5	6
239	R:R:I140	R:R:R144	6.26	No	No	0	9	9
240	R:R:M227	R:R:S141	4.6	No	No	2	8	9
241	R:R:C230	R:R:S141	5.16	No	No	0	7	9
242	R:R:S141	R:R:Y231	13.99	No	Yes	2	9	9
243	R:R:L146	R:R:V142	2.98	No	No	0	5	6
244	R:R:D143	R:R:R159	13.1	No	Yes	10	8	3
245	R:R:R144	R:R:Y231	6.17	No	Yes	0	9	9
246	R:R:R144	R:R:Y314	4.12	No	Yes	0	9	9
247	R:R:V149	R:R:Y145	10.09	No	Yes	11	7	8
248	R:R:H150	R:R:Y145	9.8	Yes	Yes	11	6	8
249	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
250	R:R:F233	R:R:Y145	5.16	No	Yes	0	4	8
251	R:R:T234	R:R:Y145	2.5	No	Yes	0	8	8
252	R:R:L146	R:R:L155	2.77	No	No	0	5	4
253	R:R:A147	R:R:R159	5.53	No	Yes	0	8	3
254	R:R:H150	R:R:V149	6.92	Yes	No	11	6	7
255	R:R:T237	R:R:V149	7.93	No	No	0	5	7
256	R:R:H150	R:R:L155	7.71	Yes	No	0	6	4
257	R:R:K158	R:R:L155	5.64	No	No	0	6	4
258	R:R:Q157	R:R:T156	5.67	No	No	0	7	2
259	R:R:R159	R:R:T156	3.88	Yes	No	0	3	2
260	R:R:Q157	R:R:Y160	11.27	No	No	0	7	5
261	R:R:I165	R:R:L161	2.85	No	No	0	5	4
262	R:R:F164	R:R:K163	3.72	No	No	0	3	4
263	R:R:L172	R:R:L176	5.54	No	No	0	4	4
264	R:R:F218	R:R:L176	3.65	No	No	0	4	4
265	R:R:R184	R:R:V180	10.46	Yes	No	1	5	4
266	R:R:F183	R:R:L182	4.87	No	No	0	5	4
267	R:R:F183	R:R:M200	8.71	No	Yes	0	5	5
268	R:R:C196	R:R:R184	2.79	No	Yes	1	9	5
269	R:R:E198	R:R:R184	12.79	Yes	Yes	1	5	5
270	R:R:D199	R:R:R185	8.34	No	No	0	4	4
271	R:R:V187	R:R:Y197	2.52	No	Yes	1	3	3
272	R:R:P194	R:R:Y188	5.56	No	No	0	5	1
273	R:R:P194	R:R:S193	3.56	No	No	0	5	3
274	R:R:E198	R:R:Y197	7.86	Yes	Yes	1	5	3
275	R:R:R208	R:R:Y197	19.55	Yes	Yes	1	4	3
276	R:R:E198	R:R:M200	2.71	Yes	Yes	0	5	5
277	R:R:E198	R:R:R208	10.47	Yes	Yes	1	5	4
278	R:R:M200	R:R:T204	3.01	Yes	No	0	5	3
279	R:R:M200	R:R:W207	4.65	Yes	No	0	5	3
280	R:R:L211	R:R:M200	5.65	No	Yes	0	4	5
281	R:R:N203	R:R:N206	9.54	No	No	0	4	1
282	R:R:R208	R:R:R212	3.2	Yes	Yes	1	4	5
283	R:R:M209	R:R:T275	3.01	No	No	0	3	4
284	R:R:M209	R:R:R278	4.96	No	Yes	0	3	4
285	R:R:M209	R:R:T279	4.52	No	No	0	3	1
286	R:R:L271	R:R:R212	12.15	No	Yes	0	6	5
287	R:R:D274	R:R:R212	4.76	Yes	Yes	1	4	5
288	R:R:R212	R:R:T275	6.47	Yes	No	0	5	4
289	R:R:I213	R:R:L214	2.85	No	No	0	4	3
290	R:R:N268	R:R:Q216	9.24	No	No	0	8	5
291	R:R:L271	R:R:Q216	9.32	No	No	0	6	5
292	R:R:F218	R:R:S217	6.61	No	No	0	4	4
293	R:R:F220	R:R:L224	2.44	Yes	Yes	0	8	7
294	R:R:F220	R:R:L265	7.31	Yes	No	0	8	6
295	R:R:F220	R:R:N268	14.5	Yes	No	0	8	8
296	R:R:I221	R:R:L225	2.85	No	No	0	4	3
297	R:R:P223	R:R:V222	7.07	Yes	No	0	9	5
298	R:R:I226	R:R:V222	3.07	No	No	0	6	5
299	R:R:L224	R:R:L228	6.92	Yes	No	0	7	4
300	R:R:F260	R:R:L224	3.65	Yes	Yes	0	9	7
301	R:R:L224	R:R:L261	5.54	Yes	No	0	7	6
302	R:R:M227	R:R:Y231	4.79	No	Yes	2	8	9
303	R:R:F260	R:R:M227	8.71	Yes	No	2	9	8
304	R:R:F229	R:R:F233	11.79	No	No	0	4	4
305	R:R:I253	R:R:Y231	12.09	No	Yes	0	7	9
306	R:R:V257	R:R:Y231	2.52	No	Yes	0	7	9
307	R:R:L238	R:R:T234	2.95	No	No	0	8	8
308	R:R:L235	R:R:M250	2.83	No	No	0	4	5
309	R:R:I253	R:R:L235	8.56	No	No	0	7	4
310	R:R:K240	R:R:T237	3	No	No	0	5	5
311	R:R:F239	R:R:M250	3.73	No	No	0	5	5
312	R:R:A241	R:R:M243	3.22	No	No	0	3	4
313	R:R:G244	R:R:Q245	3.29	No	No	0	4	4
314	R:R:H247	R:R:K246	7.86	No	No	0	5	7
315	R:R:I317	R:R:R248	2.51	No	No	0	6	7
316	R:R:I313	R:R:V256	3.07	No	No	2	7	8
317	R:R:V256	R:R:Y314	5.05	No	Yes	2	8	9
318	R:R:F260	R:R:W264	8.02	Yes	Yes	2	9	8
319	R:R:C263	R:R:W264	2.61	No	Yes	0	7	8
320	R:R:H306	R:R:W264	6.35	Yes	Yes	2	9	8
321	R:R:L265	R:R:P266	3.28	No	No	0	6	9
322	R:R:L265	R:R:L269	6.92	No	No	0	6	6
323	R:R:P266	R:R:T299	3.5	No	No	0	9	6
324	R:R:L271	R:R:Y267	4.69	No	No	0	6	7
325	R:R:T299	R:R:Y267	6.24	No	No	0	6	7
326	R:R:E300	R:R:Y267	7.86	No	No	0	5	7
327	R:R:A295	R:R:V270	3.39	No	No	0	5	4
328	R:R:L296	R:R:V270	5.96	No	No	0	5	4
329	R:R:L272	R:R:L276	2.77	No	No	0	5	4
330	R:R:D274	R:R:R278	13.1	Yes	Yes	1	4	4
331	R:R:D274	R:R:I292	4.2	Yes	Yes	1	4	5
332	R:R:L276	R:R:V281	5.96	No	No	0	4	4
333	R:R:I282	R:R:L276	4.28	No	No	0	5	4
334	R:R:E284	R:R:M277	6.77	Yes	Yes	1	3	4
335	R:R:M277	R:R:R289	2.48	Yes	Yes	1	4	3
336	R:R:I292	R:R:M277	2.92	Yes	Yes	1	5	4
337	R:R:T279	R:R:V281	3.17	No	No	0	1	4
338	R:R:E284	R:R:Q280	5.1	Yes	No	0	3	2
339	R:R:I282	R:R:R288	3.76	No	No	0	5	1
340	R:R:E284	R:R:R289	10.47	Yes	Yes	1	3	3
341	R:R:R288	R:R:T285	5.17	No	No	0	1	5
342	R:R:N290	R:R:R294	13.26	No	No	5	3	2
343	R:R:I292	R:R:L296	2.85	Yes	No	0	5	5
344	R:R:D297	R:R:I301	5.6	No	No	0	4	5
345	R:R:H306	R:R:S307	2.79	Yes	Yes	2	9	8
346	R:R:H306	R:R:N310	3.83	Yes	Yes	2	9	9
347	R:R:N310	R:R:Y314	5.81	Yes	Yes	2	9	9
348	R:R:F316	R:R:P311	2.89	Yes	No	0	6	9
349	R:R:F316	R:R:L312	2.44	Yes	No	0	6	6
350	R:R:I313	R:R:Y314	6.04	No	Yes	2	7	9
351	R:R:A315	R:R:F321	5.55	No	Yes	9	7	8
352	R:R:H323	R:R:Q319	2.47	No	No	0	4	5
353	R:R:H323	R:R:K327	6.55	No	No	0	4	4
354	R:R:D84	R:R:F321	2.39	No	Yes	0	8	8
355	R:R:L210	R:R:W207	2.28	No	No	0	2	3
356	R:R:N203	R:R:W207	2.26	No	No	0	4	3
357	L:L:G73	L:L:G74	2.11	No	No	0	0	0
358	N:N:G73	N:N:G74	2.11	No	No	0	0	0
359	R:R:F50	R:R:Y49	2.06	No	No	0	5	2
360	R:R:G65	R:R:P311	2.03	No	No	0	7	9
361	R:R:G219	R:R:P223	2.03	No	Yes	0	5	9
362	L:L:A60	L:L:P61	1.87	No	No	0	0	0
363	N:N:A60	N:N:P61	1.87	No	No	0	0	0
364	R:R:A37	R:R:P38	1.87	No	Yes	0	7	7
365	R:R:A138	R:R:P223	1.87	No	Yes	0	7	9
366	R:R:G111	R:R:S107	1.86	No	No	0	4	5
367	R:R:G133	R:R:S132	1.86	No	No	0	9	6
368	L:L:G21	L:L:V22	1.84	No	No	0	0	0
369	N:N:G21	N:N:V22	1.84	No	No	0	0	0
370	R:R:G79	R:R:V78	1.84	No	No	0	6	5
371	L:L:G21	L:L:T19	1.82	No	Yes	0	0	0
372	N:N:G21	N:N:T19	1.82	No	No	0	0	0
373	R:R:G201	R:R:T204	1.82	No	No	0	4	3
374	L:L:P24	L:L:V66	1.77	No	No	0	0	0
375	L:L:P58	L:L:V44	1.77	No	Yes	0	0	0
376	L:L:V45	R:R:P38	1.77	No	Yes	0	0	7
377	N:N:P24	N:N:V66	1.77	No	No	0	0	0
378	N:N:P58	N:N:V44	1.77	No	Yes	0	0	0
379	L:L:G36	L:L:I35	1.76	No	Yes	0	0	0
380	L:L:I35	N:N:G73	1.76	Yes	No	0	0	0
381	L:L:G73	N:N:I35	1.76	No	No	0	0	0
382	N:N:G36	N:N:I35	1.76	No	No	0	0	0
383	R:R:G324	R:R:K327	1.74	No	No	0	5	4
384	L:L:S40	R:R:A205	1.71	No	No	0	0	1
385	N:N:C15	N:N:V45	1.71	No	No	4	0	0
386	N:N:C55	N:N:V45	1.71	No	No	4	0	0
387	R:R:A98	R:R:S62	1.71	No	No	0	5	8
388	R:R:G171	R:R:L174	1.71	No	No	0	4	5
389	R:R:G303	R:R:L302	1.71	No	No	0	7	7
390	R:R:A151	R:R:T152	1.68	No	No	0	8	5
391	L:L:G21	L:L:Q20	1.64	No	No	0	0	0
392	N:N:G21	N:N:Q20	1.64	No	No	0	0	0
393	N:N:G36	N:N:Q38	1.64	No	No	0	0	0
394	R:R:L178	R:R:P179	1.64	No	No	0	3	8
395	R:R:L211	R:R:P179	1.64	No	No	0	4	8
396	R:R:L214	R:R:P215	1.64	No	No	0	3	5
397	R:R:C263	R:R:I259	1.64	No	No	0	7	6
398	R:R:L302	R:R:P266	1.64	No	No	0	7	9
399	R:R:S193	R:R:V192	1.62	No	No	0	3	5
400	R:R:V252	R:R:V256	1.6	No	No	0	7	8
401	R:R:A249	R:R:L238	1.58	No	No	0	7	8
402	R:R:A205	R:R:N206	1.56	No	No	0	1	1
403	R:R:I317	R:R:V252	1.54	No	No	0	6	7
404	L:L:K49	L:L:S28	1.53	No	No	0	0	0
405	L:L:C13	L:L:E43	1.52	No	Yes	3	0	0
406	L:L:C39	L:L:E43	1.52	No	Yes	3	0	0
407	N:N:C13	N:N:E43	1.52	No	Yes	4	0	0
408	N:N:C39	N:N:E43	1.52	No	Yes	4	0	0
409	R:R:I148	R:R:T234	1.52	No	No	0	8	8
410	R:R:I148	R:R:T237	1.52	No	No	0	8	5
411	R:R:G318	R:R:R322	1.5	No	No	0	7	8
412	R:R:L305	R:R:V58	1.49	No	No	0	5	7
413	R:R:N110	R:R:V109	1.48	No	No	0	4	4
414	R:R:I301	R:R:I54	1.47	No	No	0	5	5
415	R:R:K246	R:R:M243	1.44	No	No	0	7	4
416	R:R:I259	R:R:L309	1.43	No	No	0	6	6
417	R:R:I113	R:R:N110	1.42	No	No	0	3	4
418	N:N:L48	N:N:M26	1.41	No	No	0	0	0
419	R:R:L88	R:R:M70	1.41	No	No	0	5	6
420	R:R:G171	R:R:W170	1.41	No	Yes	0	4	9
421	R:R:L238	R:R:M243	1.41	No	No	0	8	4
422	L:L:K52	L:L:N50	1.4	No	No	0	0	0
423	N:N:K52	N:N:N50	1.4	No	No	0	0	0
424	R:R:L63	R:R:L95	1.38	No	No	0	5	7
425	R:R:L325	R:R:L68	1.38	No	No	0	6	6
426	R:R:L175	R:R:L178	1.38	No	No	0	4	3
427	R:R:L326	R:R:L329	1.38	No	No	0	4	6
428	R:R:E45	R:R:K48	1.35	No	No	0	4	4
429	R:R:A195	R:R:Y197	1.33	No	Yes	0	3	3
430	L:L:D72	L:L:Q68	1.31	No	No	0	0	0
431	N:N:D72	N:N:Q68	1.31	No	No	0	0	0
432	N:N:D57	N:N:E59	1.3	No	No	0	0	0
433	R:R:F220	R:R:I221	1.26	Yes	No	0	8	4
434	R:R:F59	R:R:L60	1.22	No	No	0	7	4
435	R:R:F254	R:R:L235	1.22	No	No	0	4	4
436	R:R:Q319	R:R:R322	1.17	No	No	0	5	8
437	R:R:H150	R:R:R153	1.13	Yes	No	0	6	5
438	R:R:H247	R:R:R251	1.13	No	No	0	5	5
439	R:R:R248	R:R:R322	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E10	7.044	5	1	0
2	L:L:R12	7.47667	6	1	0
3	L:L:T19	2.7925	4	6	0
4	L:L:F33	8.65	4	3	0
5	L:L:I35	3.0625	4	0	0
6	L:L:E43	4.632	5	3	0
7	L:L:V44	4.625	4	7	0
8	L:L:L56	3.5325	4	7	0
9	L:L:L63	5.035	4	7	0
10	N:N:N29	6.745	4	3	0
11	N:N:E43	4.632	5	4	0
12	N:N:V44	4.625	4	8	0
13	N:N:L56	3.5325	4	8	0
14	N:N:L63	5.035	4	8	0
15	R:R:P38	4.2875	4	0	7
16	R:R:N66	4.7	4	0	9
17	R:R:Y86	4.97	6	0	7
18	R:R:L90	4.12	4	2	9
19	R:R:D94	4.85	5	2	9
20	R:R:F97	5.16	5	2	6
21	R:R:W112	4.60857	7	1	9
22	R:R:F114	2.6825	4	1	6
23	R:R:Y131	5.842	5	0	7
24	R:R:I134	4.535	4	2	8
25	R:R:Y145	6.854	5	11	8
26	R:R:H150	6.39	4	11	6
27	R:R:R159	6.6075	4	10	3
28	R:R:W170	4.44	5	0	9
29	R:R:R184	8.138	5	1	5
30	R:R:Y197	7.62667	6	1	3
31	R:R:E198	8.4575	4	1	5
32	R:R:M200	4.946	5	0	5
33	R:R:R208	10.63	4	1	4
34	R:R:R212	6.246	5	1	5
35	R:R:F220	6.3775	4	0	8
36	R:R:P223	3.59	4	0	9
37	R:R:L224	4.6375	4	0	7
38	R:R:Y231	7.912	5	2	9
39	R:R:F260	6.0375	4	2	9
40	R:R:W264	6.54	5	2	8
41	R:R:D274	8.094	5	1	4
42	R:R:M277	3.9725	4	1	4
43	R:R:R278	8.15	4	1	4
44	R:R:E284	7.2425	4	1	3
45	R:R:R289	6.768	5	1	3
46	R:R:I292	3.12	4	1	5
47	R:R:I304	4.66	4	2	7
48	R:R:H306	4.028	5	2	9
49	R:R:S307	3.7225	4	2	8
50	R:R:N310	5.465	4	2	9
51	R:R:Y314	6.782	5	2	9
52	R:R:F316	2.5975	4	0	6
53	R:R:F321	4.1525	4	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E10	R:R:R208	22.6319	9.3	Yes	Yes	1	0	4
2	R:R:R208	R:R:Y197	24.824	19.55	Yes	Yes	1	4	3
3	L:L:R12	R:R:D274	13.1945	11.91	Yes	Yes	1	0	4
4	L:L:E10	R:R:R278	10.3857	8.14	Yes	Yes	1	0	4
5	L:L:R12	R:R:R289	10.3636	9.6	Yes	Yes	1	0	3
6	L:L:E43	L:L:V14	27.7654	8.56	Yes	No	0	0	0
7	L:L:V14	R:R:N191	28.6881	4.43	No	No	0	0	2
8	R:R:N191	R:R:P41	29.6085	9.77	No	No	0	2	4
9	R:R:P41	R:R:V192	31.4422	3.53	No	No	0	4	5
10	R:R:S193	R:R:V192	32.3556	1.62	No	No	0	3	5
11	R:R:G111	R:R:S193	41.3613	3.71	No	No	0	4	3
12	R:R:G111	R:R:S107	42.2491	1.86	No	No	0	4	5
13	R:R:S107	R:R:W112	43.1346	7.41	No	Yes	0	5	9
14	R:R:C119	R:R:W112	20.078	6.53	No	Yes	1	9	9
15	R:R:C119	R:R:R184	20.4631	2.79	No	Yes	1	9	5
16	R:R:E198	R:R:R184	100	12.79	Yes	Yes	1	5	5
17	R:R:E198	R:R:R208	25.3243	10.47	Yes	Yes	1	5	4
18	R:R:C196	R:R:W112	20.078	6.53	No	Yes	1	9	9
19	R:R:C196	R:R:R184	20.4631	2.79	No	Yes	1	9	5
20	L:L:P37	R:R:Y197	94.5663	2.78	No	Yes	0	0	3
21	L:L:G36	L:L:P37	91.6749	4.06	No	No	0	0	0
22	L:L:G36	L:L:I35	91.2525	1.76	No	Yes	0	0	0
23	L:L:I35	L:L:V42	89.5398	3.07	Yes	No	0	0	0
24	L:L:P58	L:L:V42	89.1058	3.53	No	No	0	0	0
25	L:L:P58	L:L:V44	86.9009	1.77	No	Yes	0	0	0
26	L:L:L56	L:L:V44	14.1288	2.98	Yes	Yes	7	0	0
27	L:L:F62	L:L:L56	15.8078	3.65	No	Yes	0	0	0
28	L:L:F62	L:L:V66	15.0782	9.18	No	No	0	0	0
29	L:L:E43	L:L:F33	18.3152	7	Yes	Yes	3	0	0
30	L:L:F33	L:L:Q31	12.5883	12.88	Yes	No	3	0	0
31	L:L:Q31	N:N:Q31	11.7121	12.8	No	No	0	0	0
32	N:N:F33	N:N:Q31	10.7546	12.88	No	No	0	0	0
33	N:N:I70	N:N:V66	25.4861	3.07	No	No	0	0	0
34	N:N:F62	N:N:V66	35.1841	9.18	No	No	0	0	0
35	N:N:F62	N:N:L56	37.1168	3.65	No	Yes	0	0	0
36	N:N:L56	N:N:L63	40.6085	2.77	Yes	Yes	8	0	0
37	L:L:L71	N:N:L63	23.8513	4.15	No	Yes	0	0	0
38	L:L:I67	L:L:L71	24.4528	2.85	No	No	0	0	0
39	L:L:I67	L:L:L63	49.4502	4.28	No	Yes	0	0	0
40	L:L:L63	L:L:V44	71.8704	8.94	Yes	Yes	7	0	0
41	N:N:I67	N:N:L63	47.6584	4.28	No	Yes	0	0	0
42	L:L:I67	N:N:I67	24.447	2.94	No	No	0	0	0
43	N:N:I67	N:N:L71	24.4528	2.85	No	No	0	0	0
44	L:L:L63	N:N:L71	25.0486	4.15	Yes	No	0	0	0
45	N:N:L63	N:N:V44	29.0058	8.94	Yes	Yes	8	0	0
46	N:N:P58	N:N:V44	25.4861	1.77	No	Yes	0	0	0
47	N:N:P58	N:N:V42	15.7298	3.53	No	No	0	0	0
48	N:N:I35	N:N:V42	13.7716	3.07	No	No	0	0	0
49	N:N:I70	N:N:L30	21.5906	2.85	No	No	0	0	0
50	N:N:I27	N:N:L30	19.6393	2.85	No	No	0	0	0
51	N:N:I27	N:N:L48	17.6857	2.85	No	No	0	0	0
52	R:R:L271	R:R:R212	19.0098	12.15	No	Yes	0	6	5
53	R:R:R184	R:R:S123	32.9141	11.86	Yes	No	1	5	5
54	R:R:S123	R:R:W104	32.9571	2.47	No	No	0	5	6
55	R:R:K126	R:R:W104	42.2642	6.96	No	No	0	6	6
56	R:R:F97	R:R:K126	42.1037	7.44	Yes	No	0	6	6
57	R:R:F97	R:R:S307	15.7147	2.64	Yes	Yes	2	6	8
58	R:R:F97	R:R:H306	25.2499	3.39	Yes	Yes	2	6	9
59	R:R:D94	R:R:H306	15.7799	3.78	Yes	Yes	2	9	9
60	R:R:D94	R:R:N66	27.1418	6.73	Yes	Yes	0	9	9
61	R:R:D94	R:R:S307	13.2434	2.94	Yes	Yes	2	9	8
62	R:R:A91	R:R:N66	15.1504	4.69	No	Yes	0	8	9
63	R:R:A91	R:R:V69	14.1614	3.39	No	No	0	8	8
64	R:R:I73	R:R:V69	13.2794	3.07	No	No	0	6	8
65	R:R:R184	R:R:V180	33.4342	10.46	Yes	No	1	5	4
66	R:R:E127	R:R:V180	33.4854	8.56	No	No	0	4	4
67	R:R:E127	R:R:Y131	33.113	8.98	No	Yes	0	4	7
68	R:R:L271	R:R:Q216	14.2254	9.32	No	No	0	6	5
69	R:R:N268	R:R:Q216	14.0287	9.24	No	No	0	8	5
70	R:R:F220	R:R:N268	13.8647	14.5	Yes	No	0	8	8
71	R:R:F220	R:R:L224	14.5744	2.44	Yes	Yes	0	8	7
72	R:R:F260	R:R:L224	14.6477	3.65	Yes	Yes	0	9	7
73	R:R:F260	R:R:M227	28.6392	8.71	Yes	No	2	9	8
74	R:R:H306	R:R:N310	10.1297	3.83	Yes	Yes	2	9	9
75	R:R:N310	R:R:Y314	10.5533	5.81	Yes	Yes	2	9	9
76	R:R:V122	R:R:W112	16.1987	2.45	No	Yes	0	5	9
77	R:R:V122	R:R:W104	13.3725	2.45	No	No	0	5	6
78	R:R:F130	R:R:Y131	21.2205	7.22	No	Yes	0	7	7
79	R:R:F130	R:R:I134	10.3427	6.28	No	Yes	2	7	8
80	R:R:F130	R:R:W264	10.6568	11.02	No	Yes	2	7	8
81	R:R:F260	R:R:W264	15.6519	8.02	Yes	Yes	2	9	8
82	R:R:M227	R:R:S141	20.0163	4.6	No	No	2	8	9
83	R:R:C230	R:R:S141	21.2962	5.16	No	No	0	7	9
84	R:R:C230	R:R:Y145	20.3526	6.72	No	Yes	0	7	8
85	R:R:E198	R:R:M200	10.8546	2.71	Yes	Yes	0	5	5
86	R:R:D274	R:R:R212	11.099	4.76	Yes	Yes	1	4	5
87	R:R:R208	R:R:R212	27.1127	3.2	Yes	Yes	1	4	5
88	R:R:H306	R:R:W264	10.3206	6.35	Yes	Yes	2	9	8
89	R:R:E198	R:R:Y197	72.9059	7.86	Yes	Yes	1	5	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:E10	R:R:R208	9.3	1	Yes	Yes	0	4	0	1
L:L:E10	R:R:R212	4.65	1	Yes	Yes	0	5	0	1
L:L:E10	R:R:D274	6.5	1	Yes	Yes	0	4	0	1
L:L:E10	R:R:R278	8.14	1	Yes	Yes	0	4	0	1
L:L:E10	R:R:L296	6.63	1	Yes	No	0	5	0	1
L:L:L11	R:R:V187	2.98	1	No	No	0	3	0	1
L:L:L11	R:R:Y197	11.72	1	No	Yes	0	3	0	1
L:L:R12	R:R:D274	11.91	1	Yes	Yes	0	4	0	1
L:L:R12	R:R:M277	3.72	1	Yes	Yes	0	4	0	1
L:L:R12	R:R:R278	6.4	1	Yes	Yes	0	4	0	1
L:L:R12	R:R:R289	9.6	1	Yes	Yes	0	3	0	1
L:L:R12	R:R:I292	2.51	1	Yes	Yes	0	5	0	1
L:L:R12	R:R:D293	10.72	1	Yes	No	0	4	0	1
L:L:V14	R:R:N191	4.43	0	No	No	0	2	0	1
L:L:L16	R:R:E284	6.63	1	No	Yes	0	3	0	1
L:L:L16	R:R:R289	8.5	1	No	Yes	0	3	0	1
L:L:Q17	R:R:D35	10.44	0	No	No	0	6	0	1
L:L:T19	R:R:L33	2.95	6	Yes	No	0	3	0	1
L:L:T19	R:R:A36	3.36	6	Yes	No	0	5	0	1
L:L:Q31	R:R:S190	2.89	3	No	No	0	2	0	1
L:L:F33	R:R:S190	2.64	3	Yes	No	0	2	0	1
L:L:I35	R:R:N202	5.66	0	Yes	No	0	2	0	1
L:L:P37	R:R:Y197	2.78	0	No	Yes	0	3	0	1
L:L:P37	R:R:D199	6.44	0	No	No	0	4	0	1
L:L:Q38	R:R:V187	2.87	1	No	No	0	3	0	1
L:L:Q38	R:R:S189	5.78	1	No	No	0	1	0	1
L:L:E53	R:R:P38	7.86	0	No	Yes	0	7	0	1
L:L:I54	R:R:L33	4.28	6	No	No	0	3	0	1
L:L:C55	R:R:P38	5.65	0	No	Yes	0	7	0	1
N:N:N29	R:R:S190	4.47	3	Yes	No	0	2	0	1
N:N:K49	R:R:R185	3.71	0	No	No	0	4	0	1
N:N:G51	R:R:Y188	10.14	0	No	No	0	1	0	1
R:R:C39	R:R:R289	2.79	0	No	Yes	8	3	2	1
R:R:N191	R:R:P41	9.77	0	No	No	2	4	1	2
R:R:R185	R:R:T116	2.59	0	No	No	4	3	1	2
R:R:D199	R:R:R185	8.34	0	No	No	4	4	1	1
R:R:V187	R:R:Y197	2.52	1	No	Yes	3	3	1	1
R:R:P194	R:R:Y188	5.56	0	No	No	5	1	2	1
R:R:E198	R:R:Y197	7.86	1	Yes	Yes	5	3	2	1
R:R:R208	R:R:Y197	19.55	1	Yes	Yes	4	3	1	1
R:R:E198	R:R:R208	10.47	1	Yes	Yes	5	4	2	1
R:R:R208	R:R:R212	3.2	1	Yes	Yes	4	5	1	1
R:R:M209	R:R:T275	3.01	0	No	No	3	4	2	2
R:R:M209	R:R:R278	4.96	0	No	Yes	3	4	2	1
R:R:L271	R:R:R212	12.15	0	No	Yes	6	5	2	1
R:R:D274	R:R:R212	4.76	1	Yes	Yes	4	5	1	1
R:R:R212	R:R:T275	6.47	1	Yes	No	5	4	1	2
R:R:L296	R:R:V270	5.96	0	No	No	5	4	1	2
R:R:D274	R:R:R278	13.1	1	Yes	Yes	4	4	1	1
R:R:D274	R:R:I292	4.2	1	Yes	Yes	4	5	1	1
R:R:E284	R:R:M277	6.77	1	Yes	Yes	3	4	1	1
R:R:M277	R:R:R289	2.48	1	Yes	Yes	4	3	1	1
R:R:I292	R:R:M277	2.92	1	Yes	Yes	5	4	1	1
R:R:E284	R:R:Q280	5.1	1	Yes	No	3	2	1	2
R:R:E284	R:R:R289	10.47	1	Yes	Yes	3	3	1	1
R:R:I292	R:R:L296	2.85	1	Yes	No	5	5	1	1
R:R:A37	R:R:P38	1.87	0	No	Yes	7	7	2	1
L:L:V45	R:R:P38	1.77	0	No	Yes	0	7	0	1
L:L:S40	R:R:A205	1.71	0	No	No	0	1	0	1
R:R:A205	R:R:N206	1.56	0	No	No	1	1	1	2
R:R:A195	R:R:Y197	1.33	0	No	Yes	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XX7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	393
Number of Links	439
Number of Hubs	53
Number of Links mediated by Hubs	187
Number of Communities	11
Number of Nodes involved in Communities	77
Number of Links involved in Communities	104

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	160419
Length Of Smallest Path	3
Average Path Length	19.4326
Length of Longest Path	41
Minimum Path Strength	1.12
Average Path Strength	5.49469
Maximum Path Strength	15.635
Minimum Path Correlation	0.7
Average Path Correlation	0.954702
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	53.9805
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1829
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body • G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • positive regulation of cytosolic calcium ion concentration • import into cell • receptor internalization • receptor-mediated endocytosis • endocytosis • immune response • immune system process • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • neutrophil activation • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • taxis • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • calcium-mediated signaling • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • defense response • response to stress • cellular defense response • inflammatory response • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to interleukin-8 • response to interleukin-8 • cellular response to cytokine stimulus • interleukin-8-mediated signaling pathway • cell surface • external side of plasma membrane • mast cell granule • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • molecular function activator activity • signaling receptor activator activity • cytokine receptor binding • chemokine activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • identical protein binding • CXCR chemokine receptor binding • humoral immune response • biological process involved in interspecies interaction between organisms • response to other organism • defense response to symbiont • antimicrobial humoral response • response to biotic stimulus • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to external biotic stimulus • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to biotic stimulus • response to bacterium • response to molecule of bacterial origin
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XX7_nogp_Chain_R P F L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XX7_nogp.zip

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