psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R2	R:R:S43	5.27	No	No	0	0	5
2	L:L:K5	R:R:K108	5.75	No	Yes	5	0	5
3	L:L:K5	R:R:D297	5.53	No	No	5	0	4
4	L:L:K5	R:R:E300	12.15	No	No	5	0	5
5	L:L:E6	L:L:R8	5.82	Yes	Yes	1	0	0
6	L:L:E6	R:R:R208	11.63	Yes	Yes	1	0	4
7	L:L:E6	R:R:R212	5.82	Yes	Yes	1	0	5
8	L:L:E6	R:R:D274	9.09	Yes	Yes	1	0	4
9	L:L:E6	R:R:R278	6.98	Yes	Yes	1	0	4
10	L:L:E6	R:R:L296	3.98	Yes	No	0	0	5
11	L:L:L7	R:R:S189	4.5	No	No	0	0	1
12	L:L:L7	R:R:Y197	7.03	No	Yes	0	0	3
13	L:L:R8	R:R:D274	11.91	Yes	Yes	1	0	4
14	L:L:R8	R:R:M277	3.72	Yes	Yes	1	0	4
15	L:L:R8	R:R:R278	7.46	Yes	Yes	1	0	4
16	L:L:R8	R:R:R289	12.79	Yes	Yes	1	0	3
17	L:L:R8	R:R:D293	8.34	Yes	No	0	0	4
18	L:L:C36	L:L:C9	7.28	No	No	2	0	0
19	L:L:C9	L:L:E40	3.04	No	Yes	2	0	0
20	L:L:Q10	L:L:R28	3.5	Yes	Yes	2	0	0
21	L:L:E40	L:L:Q10	5.1	Yes	Yes	2	0	0
22	L:L:I42	L:L:Q10	4.12	Yes	Yes	2	0	0
23	L:L:Q10	R:R:N191	15.85	Yes	No	0	0	2
24	L:L:C11	L:L:E40	6.08	No	Yes	0	0	0
25	L:L:C11	L:L:I42	3.27	No	Yes	0	0	0
26	L:L:C11	L:L:C52	7.28	No	No	0	0	0
27	L:L:I12	R:R:E284	5.47	No	Yes	1	0	3
28	L:L:I12	R:R:R289	5.01	No	Yes	1	0	3
29	L:L:K17	L:L:Y15	9.55	No	Yes	0	0	0
30	L:L:F19	L:L:Y15	3.09	Yes	Yes	8	0	0
31	L:L:L51	L:L:Y15	9.38	No	Yes	0	0	0
32	L:L:Y15	R:R:P31	4.17	Yes	Yes	8	0	5
33	L:L:P18	L:L:W59	13.51	No	Yes	0	0	0
34	L:L:F19	L:L:I24	5.02	Yes	No	0	0	0
35	L:L:F19	L:L:W59	7.02	Yes	Yes	0	0	0
36	L:L:F19	R:R:P31	13	Yes	Yes	8	0	5
37	L:L:H20	L:L:P21	13.73	No	No	0	0	0
38	L:L:H20	L:L:K22	11.79	No	No	0	0	0
39	L:L:K66	L:L:P21	5.02	No	No	0	0	0
40	L:L:F23	L:L:K22	11.17	Yes	No	0	0	0
41	L:L:K22	R:R:T28	4.5	No	No	0	0	7
42	L:L:F23	L:L:S46	3.96	Yes	No	0	0	0
43	L:L:F23	R:R:P30	4.33	Yes	No	0	0	3
44	L:L:F23	R:R:P31	7.22	Yes	Yes	0	0	5
45	L:L:I24	L:L:V43	3.07	No	No	0	0	0
46	L:L:F67	L:L:I24	8.79	Yes	No	0	0	0
47	L:L:K25	N:N:E27	4.05	No	Yes	0	0	0
48	L:L:E26	L:L:K44	5.4	No	No	0	0	0
49	L:L:E26	N:N:R24	15.12	No	Yes	7	0	0
50	L:L:E26	N:N:I26	15.03	No	No	7	0	0
51	L:L:L27	L:L:V29	4.47	No	No	0	0	0
52	L:L:F67	L:L:L27	7.31	Yes	No	9	0	0
53	L:L:L27	L:L:L68	4.15	No	Yes	9	0	0
54	L:L:I30	L:L:R28	5.01	No	Yes	2	0	0
55	L:L:I42	L:L:R28	6.26	Yes	Yes	2	0	0
56	L:L:E50	L:L:R28	3.49	No	Yes	0	0	0
57	L:L:R28	N:N:E22	5.82	Yes	Yes	2	0	0
58	L:L:I41	L:L:V29	3.07	No	No	0	0	0
59	L:L:H35	L:L:I30	3.98	No	No	0	0	0
60	L:L:I30	N:N:E22	10.93	No	Yes	2	0	0
61	L:L:E31	N:N:K21	5.4	No	No	0	0	0
62	L:L:E31	N:N:F63	3.5	No	Yes	10	0	0
63	L:L:E31	N:N:R66	12.79	No	No	10	0	0
64	L:L:S32	L:L:T39	3.2	No	No	0	0	0
65	L:L:S32	R:R:N202	7.45	No	No	0	0	2
66	L:L:G33	L:L:P34	4.06	No	Yes	0	0	0
67	L:L:G33	L:L:H35	3.18	No	No	0	0	0
68	L:L:P34	R:R:V187	5.3	Yes	No	0	0	3
69	L:L:P34	R:R:D199	6.44	Yes	No	0	0	4
70	L:L:P34	R:R:T204	6.99	Yes	No	0	0	3
71	L:L:C36	L:L:H35	4.42	No	No	0	0	0
72	L:L:C36	L:L:E40	3.04	No	Yes	2	0	0
73	L:L:P55	L:L:T39	3.5	No	No	0	0	0
74	L:L:T39	N:N:A67	3.36	No	No	0	0	0
75	L:L:I41	L:L:L53	5.71	No	No	0	0	0
76	L:L:I41	L:L:V64	3.07	No	No	0	0	0
77	L:L:I42	R:R:P38	3.39	Yes	Yes	0	0	7
78	L:L:L53	L:L:V43	8.94	No	No	0	0	0
79	L:L:E50	L:L:K44	12.15	No	No	0	0	0
80	L:L:L45	L:L:L51	4.15	No	No	0	0	0
81	L:L:L45	R:R:P31	8.21	No	Yes	0	0	5
82	L:L:D47	L:L:R49	22.63	No	No	0	0	0
83	L:L:R49	R:R:F32	8.55	No	No	0	0	3
84	L:L:R49	R:R:L33	9.72	No	No	0	0	3
85	L:L:E50	R:R:P38	9.43	No	Yes	0	0	7
86	L:L:C52	R:R:P38	3.77	No	Yes	0	0	7
87	L:L:L53	L:L:V60	5.96	No	No	0	0	0
88	L:L:D54	L:L:P55	6.44	Yes	No	0	0	0
89	L:L:D54	L:L:E57	9.09	Yes	No	0	0	0
90	L:L:E57	L:L:N58	3.94	No	No	0	0	0
91	L:L:E57	L:L:W59	5.45	No	Yes	0	0	0
92	L:L:V60	L:L:W59	7.36	No	Yes	0	0	0
93	L:L:V63	L:L:W59	3.68	No	Yes	0	0	0
94	L:L:Q61	N:N:E68	5.1	No	No	0	0	0
95	L:L:F67	L:L:L68	3.65	Yes	Yes	9	0	0
96	L:L:F67	N:N:E27	3.5	Yes	Yes	0	0	0
97	L:L:L68	N:N:V25	4.47	Yes	No	0	0	0
98	L:L:L68	N:N:L64	4.15	Yes	No	0	0	0
99	L:L:K69	L:L:N73	8.39	No	No	0	0	0
100	L:L:R70	N:N:E27	10.47	No	Yes	0	0	0
101	L:L:A71	N:N:E27	6.03	No	Yes	0	0	0
102	L:L:E72	N:N:Q57	16.57	No	No	0	0	0
103	N:N:C32	N:N:C5	7.28	No	No	11	0	0
104	N:N:C5	N:N:E36	6.08	No	No	11	0	0
105	N:N:Q6	N:N:R24	10.51	No	Yes	7	0	0
106	N:N:I26	N:N:Q6	4.12	No	No	7	0	0
107	N:N:C7	N:N:E36	6.08	No	No	0	0	0
108	N:N:C7	N:N:I38	3.27	No	No	0	0	0
109	N:N:C48	N:N:C7	7.28	No	No	0	0	0
110	N:N:D50	N:N:T10	4.34	Yes	No	0	0	0
111	N:N:R45	N:N:Y11	3.09	No	No	0	0	0
112	N:N:L47	N:N:Y11	12.89	No	No	0	0	0
113	N:N:P14	N:N:W55	17.57	No	Yes	0	0	0
114	N:N:F15	N:N:I20	6.28	Yes	Yes	0	0	0
115	N:N:F15	N:N:L41	3.65	Yes	No	3	0	0
116	N:N:F15	N:N:L47	3.65	Yes	No	0	0	0
117	N:N:F15	N:N:L49	3.65	Yes	Yes	3	0	0
118	N:N:F15	N:N:W55	6.01	Yes	Yes	3	0	0
119	N:N:H16	N:N:P17	12.2	No	No	0	0	0
120	N:N:H16	N:N:K18	6.55	No	No	0	0	0
121	N:N:K62	N:N:P17	8.36	No	No	0	0	0
122	N:N:I20	N:N:V39	6.14	Yes	No	0	0	0
123	N:N:I20	N:N:V59	3.07	Yes	No	0	0	0
124	N:N:F63	N:N:I20	12.56	Yes	Yes	0	0	0
125	N:N:K21	N:N:S42	7.65	No	No	0	0	0
126	N:N:E22	N:N:K40	8.1	Yes	No	2	0	0
127	N:N:E22	R:R:S190	8.62	Yes	No	2	0	2
128	N:N:F63	N:N:L23	8.53	Yes	No	0	0	0
129	N:N:I26	N:N:R24	10.02	No	Yes	7	0	0
130	N:N:I38	N:N:R24	3.76	No	Yes	0	0	0
131	N:N:I37	N:N:V25	3.07	No	No	0	0	0
132	N:N:S28	N:N:T35	3.2	No	No	0	0	0
133	N:N:G29	N:N:P30	4.06	No	No	0	0	0
134	N:N:G29	N:N:H31	3.18	No	No	0	0	0
135	N:N:C32	N:N:H31	7.37	No	No	0	0	0
136	N:N:C32	N:N:E36	3.04	No	No	11	0	0
137	N:N:P51	N:N:T35	3.5	No	No	0	0	0
138	N:N:I37	N:N:P51	5.08	No	No	0	0	0
139	N:N:L49	N:N:V39	5.96	Yes	No	0	0	0
140	N:N:E46	N:N:K40	12.15	No	No	0	0	0
141	N:N:K40	R:R:S190	6.12	No	No	2	0	2
142	N:N:D43	N:N:L41	5.43	No	No	3	0	0
143	N:N:L41	N:N:R45	4.86	No	No	3	0	0
144	N:N:D43	N:N:R45	22.63	No	No	3	0	0
145	N:N:G44	R:R:Y188	7.24	No	No	0	0	1
146	N:N:L49	N:N:W55	3.42	Yes	Yes	3	0	0
147	N:N:L49	N:N:V56	8.94	Yes	No	3	0	0
148	N:N:D50	N:N:P51	8.05	Yes	No	0	0	0
149	N:N:D50	N:N:K52	5.53	Yes	No	0	0	0
150	N:N:D50	N:N:E53	5.2	Yes	No	0	0	0
151	N:N:E53	N:N:W55	4.36	No	Yes	0	0	0
152	N:N:N54	N:N:R58	16.87	No	No	0	0	0
153	N:N:V56	N:N:W55	13.48	No	Yes	3	0	0
154	N:N:F63	N:N:R66	4.28	Yes	No	10	0	0
155	N:N:E68	N:N:K65	10.8	No	No	0	0	0
156	N:N:K65	N:N:N69	4.2	No	No	0	0	0
157	R:R:F32	R:R:L34	3.65	No	No	0	3	2
158	R:R:A37	R:R:L33	3.15	No	No	0	7	3
159	R:R:C286	R:R:C39	7.28	No	No	0	6	8
160	R:R:C39	R:R:R289	8.36	No	Yes	0	8	3
161	R:R:E40	R:R:P41	3.14	No	No	0	4	4
162	R:R:N191	R:R:P41	4.89	No	No	0	2	4
163	R:R:E42	R:R:N290	3.94	No	No	0	4	3
164	R:R:L44	R:R:N47	4.12	No	No	0	2	4
165	R:R:K48	R:R:V109	9.11	No	No	0	4	4
166	R:R:I53	R:R:Y49	7.25	No	No	0	5	2
167	R:R:F50	R:R:I54	12.56	No	No	0	5	5
168	R:R:V51	R:R:Y55	5.05	No	Yes	5	5	7
169	R:R:K108	R:R:V51	3.04	Yes	No	5	5	5
170	R:R:I301	R:R:V51	3.07	No	No	0	5	5
171	R:R:V109	R:R:V52	4.81	No	No	0	4	5
172	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
173	R:R:K108	R:R:Y55	7.17	Yes	Yes	5	5	7
174	R:R:I304	R:R:Y55	7.25	No	Yes	0	7	7
175	R:R:L57	R:R:L61	6.92	No	No	0	5	5
176	R:R:I304	R:R:V58	4.61	No	No	0	7	7
177	R:R:C308	R:R:V58	5.12	No	No	0	7	7
178	R:R:F59	R:R:P102	14.45	No	No	0	7	9
179	R:R:C308	R:R:L61	3.17	No	No	0	7	5
180	R:R:A98	R:R:S62	3.42	No	No	0	5	8
181	R:R:S307	R:R:S62	6.52	No	No	0	8	8
182	R:R:C308	R:R:S62	5.16	No	No	0	7	8
183	R:R:L64	R:R:L68	4.15	No	No	0	4	6
184	R:R:G65	R:R:P311	4.06	No	No	0	7	9
185	R:R:D94	R:R:N66	5.39	No	No	0	9	9
186	R:R:L95	R:R:N66	5.49	No	No	0	7	9
187	R:R:N66	R:R:P311	6.52	No	No	0	9	9
188	R:R:A91	R:R:V69	3.39	No	No	0	8	8
189	R:R:A315	R:R:V69	3.39	No	No	0	7	8
190	R:R:F316	R:R:V69	3.93	Yes	No	0	6	8
191	R:R:L92	R:R:M70	4.24	No	No	0	6	6
192	R:R:I73	R:R:L88	5.71	No	No	0	6	5
193	R:R:F321	R:R:I73	6.28	Yes	No	0	8	6
194	R:R:L74	R:R:R80	3.64	No	No	0	2	7
195	R:R:L74	R:R:L88	6.92	No	No	0	2	5
196	R:R:I328	R:R:Y75	10.88	No	No	0	5	4
197	R:R:D84	R:R:S81	10.31	No	No	12	8	7
198	R:R:K320	R:R:S81	3.06	No	No	12	6	7
199	R:R:D143	R:R:V82	5.84	No	No	13	8	7
200	R:R:R159	R:R:V82	3.92	Yes	No	13	3	7
201	R:R:V162	R:R:V82	3.21	No	No	0	7	7
202	R:R:D84	R:R:K320	5.53	No	No	12	8	6
203	R:R:V162	R:R:V85	8.02	No	No	0	7	6
204	R:R:C139	R:R:Y86	4.03	No	Yes	0	5	7
205	R:R:I140	R:R:Y86	6.04	No	Yes	0	9	7
206	R:R:D143	R:R:Y86	8.05	No	Yes	0	8	7
207	R:R:V162	R:R:Y86	7.57	No	Yes	0	7	7
208	R:R:I165	R:R:Y86	3.63	No	Yes	0	5	7
209	R:R:F321	R:R:L87	3.65	Yes	No	0	8	7
210	R:R:L136	R:R:N89	4.12	No	No	0	8	9
211	R:R:C166	R:R:N89	11.02	No	No	0	7	9
212	R:R:N89	R:R:W170	5.65	No	No	0	9	9
213	R:R:L136	R:R:L90	5.54	No	No	0	8	9
214	R:R:L137	R:R:L90	5.54	No	No	0	8	9
215	R:R:L90	R:R:N310	4.12	No	Yes	0	9	9
216	R:R:D94	R:R:N310	8.08	No	Yes	0	9	9
217	R:R:L96	R:R:N129	12.36	No	No	0	7	8
218	R:R:F97	R:R:L101	7.31	Yes	No	0	6	8
219	R:R:F97	R:R:K126	6.2	Yes	No	0	6	6
220	R:R:F97	R:R:H306	3.39	Yes	No	0	6	9
221	R:R:L125	R:R:T100	4.42	No	No	0	4	7
222	R:R:I304	R:R:L101	5.71	No	No	0	7	8
223	R:R:I103	R:R:W112	4.7	No	Yes	4	6	9
224	R:R:F114	R:R:I103	10.05	Yes	No	4	6	6
225	R:R:I103	R:R:V122	4.61	No	No	4	6	5
226	R:R:W104	R:R:W112	3.75	No	Yes	4	6	9
227	R:R:V122	R:R:W104	3.68	No	No	4	5	6
228	R:R:K126	R:R:W104	12.76	No	No	0	6	6
229	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
230	R:R:D297	R:R:K108	5.53	No	Yes	5	4	5
231	R:R:E300	R:R:K108	5.4	No	Yes	5	5	5
232	R:R:G111	R:R:S193	3.71	No	No	0	4	3
233	R:R:F114	R:R:W112	8.02	Yes	Yes	4	6	9
234	R:R:C119	R:R:W112	6.53	No	Yes	4	9	9
235	R:R:V122	R:R:W112	3.68	No	Yes	4	5	9
236	R:R:C196	R:R:W112	9.14	No	Yes	4	9	9
237	R:R:I113	R:R:P194	3.39	No	No	0	3	5
238	R:R:K120	R:R:T116	4.5	No	No	0	7	3
239	R:R:T116	R:R:T186	4.71	No	No	0	3	4
240	R:R:F117	R:R:V121	7.87	No	No	0	1	5
241	R:R:C119	R:R:C196	7.28	No	No	4	9	9
242	R:R:S123	R:R:V180	3.23	No	No	1	5	4
243	R:R:R184	R:R:S123	10.54	No	No	1	5	5
244	R:R:L124	R:R:L181	4.15	No	No	0	6	5
245	R:R:L125	R:R:N129	4.12	No	No	0	4	8
246	R:R:E127	R:R:Y131	8.98	No	Yes	0	4	7
247	R:R:A177	R:R:E127	4.53	No	No	0	7	4
248	R:R:E127	R:R:V180	9.98	No	No	0	4	4
249	R:R:A177	R:R:V128	3.39	No	No	0	7	5
250	R:R:F130	R:R:Y131	9.28	No	Yes	0	7	7
251	R:R:F130	R:R:I134	6.28	No	No	14	7	8
252	R:R:F130	R:R:W264	8.02	No	Yes	14	7	8
253	R:R:L176	R:R:Y131	7.03	No	Yes	0	4	7
254	R:R:P215	R:R:Y131	4.17	No	Yes	0	5	7
255	R:R:S132	R:R:W170	16.06	No	No	0	6	9
256	R:R:S132	R:R:S173	6.52	No	No	0	6	7
257	R:R:I134	R:R:P223	3.39	No	Yes	0	8	9
258	R:R:I134	R:R:W264	5.87	No	Yes	14	8	8
259	R:R:I169	R:R:L135	8.56	No	No	0	6	6
260	R:R:L137	R:R:Y314	12.89	No	Yes	0	8	9
261	R:R:C139	R:R:I169	3.27	No	No	0	5	6
262	R:R:I140	R:R:R144	6.26	No	No	0	9	9
263	R:R:M227	R:R:S141	4.6	No	No	6	8	9
264	R:R:C230	R:R:S141	5.16	No	No	0	7	9
265	R:R:S141	R:R:Y231	13.99	No	Yes	6	9	9
266	R:R:C230	R:R:V142	3.42	No	No	0	7	6
267	R:R:D143	R:R:R159	10.72	No	Yes	13	8	3
268	R:R:R144	R:R:Y231	8.23	No	Yes	0	9	9
269	R:R:R144	R:R:Y314	6.17	No	Yes	0	9	9
270	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
271	R:R:V149	R:R:Y145	12.62	No	Yes	15	7	8
272	R:R:H150	R:R:Y145	9.8	Yes	Yes	15	6	8
273	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
274	R:R:F233	R:R:Y145	4.13	No	Yes	0	4	8
275	R:R:A147	R:R:R159	5.53	No	Yes	0	8	3
276	R:R:I148	R:R:T234	6.08	No	No	0	8	8
277	R:R:H150	R:R:V149	5.54	Yes	No	15	6	7
278	R:R:T237	R:R:V149	7.93	No	No	0	5	7
279	R:R:H150	R:R:R153	4.51	Yes	No	0	6	5
280	R:R:H150	R:R:L155	5.14	Yes	No	0	6	4
281	R:R:K158	R:R:L155	7.05	No	No	0	6	4
282	R:R:Q157	R:R:T156	5.67	No	No	0	7	2
283	R:R:Q157	R:R:Y160	5.64	No	No	0	7	5
284	R:R:F164	R:R:K163	4.96	No	No	0	3	4
285	R:R:L172	R:R:L176	5.54	No	No	0	4	4
286	R:R:F218	R:R:L176	3.65	No	No	0	4	4
287	R:R:R184	R:R:V180	10.46	No	No	1	5	4
288	R:R:F183	R:R:L182	6.09	No	No	0	5	4
289	R:R:F183	R:R:M200	11.2	No	Yes	0	5	5
290	R:R:E198	R:R:R184	12.79	No	No	1	5	5
291	R:R:D199	R:R:R185	9.53	No	No	0	4	4
292	R:R:V187	R:R:Y197	5.05	No	Yes	0	3	3
293	R:R:P194	R:R:Y188	8.34	No	No	0	5	1
294	R:R:P194	R:R:S193	3.56	No	No	0	5	3
295	R:R:E198	R:R:Y197	5.61	No	Yes	1	5	3
296	R:R:R208	R:R:Y197	18.52	Yes	Yes	1	4	3
297	R:R:E198	R:R:R208	9.3	No	Yes	1	5	4
298	R:R:M200	R:R:T204	3.01	Yes	No	0	5	3
299	R:R:M200	R:R:W207	6.98	Yes	No	0	5	3
300	R:R:L211	R:R:M200	5.65	No	Yes	0	4	5
301	R:R:N203	R:R:N206	13.62	No	No	0	4	1
302	R:R:N203	R:R:W207	3.39	No	No	0	4	3
303	R:R:R208	R:R:R212	3.2	Yes	Yes	1	4	5
304	R:R:M209	R:R:T275	3.01	No	No	0	3	4
305	R:R:M209	R:R:R278	7.44	No	Yes	0	3	4
306	R:R:M209	R:R:T279	4.52	No	No	0	3	1
307	R:R:L271	R:R:R212	10.93	No	Yes	0	6	5
308	R:R:D274	R:R:R212	5.96	Yes	Yes	1	4	5
309	R:R:R212	R:R:T275	7.76	Yes	No	0	5	4
310	R:R:N268	R:R:Q216	7.92	No	No	0	8	5
311	R:R:L271	R:R:Q216	7.99	No	No	0	6	5
312	R:R:F218	R:R:S217	6.61	No	No	0	4	4
313	R:R:G219	R:R:P223	4.06	No	Yes	0	5	9
314	R:R:F220	R:R:L224	3.65	Yes	Yes	0	8	7
315	R:R:F220	R:R:L265	7.31	Yes	No	0	8	6
316	R:R:F220	R:R:N268	16.92	Yes	No	0	8	8
317	R:R:P223	R:R:V222	3.53	Yes	No	0	9	5
318	R:R:I226	R:R:V222	3.07	No	No	0	6	5
319	R:R:L224	R:R:L228	6.92	Yes	No	0	7	4
320	R:R:F260	R:R:L224	3.65	No	Yes	0	9	7
321	R:R:M227	R:R:Y231	3.59	No	Yes	6	8	9
322	R:R:F260	R:R:M227	11.2	No	No	0	9	8
323	R:R:F229	R:R:F233	12.86	No	No	0	4	4
324	R:R:I253	R:R:Y231	9.67	No	Yes	0	7	9
325	R:R:V256	R:R:Y231	3.79	Yes	Yes	6	8	9
326	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
327	R:R:I253	R:R:T234	3.04	No	No	0	7	8
328	R:R:L235	R:R:M250	4.24	No	No	0	4	5
329	R:R:I253	R:R:L235	9.99	No	No	0	7	4
330	R:R:F254	R:R:L235	3.65	No	No	0	4	4
331	R:R:F239	R:R:M250	3.73	No	No	0	5	5
332	R:R:A241	R:R:M243	4.83	No	Yes	0	3	4
333	R:R:G244	R:R:Q245	3.29	No	No	0	4	4
334	R:R:H247	R:R:K246	9.17	No	No	0	5	7
335	R:R:I317	R:R:V252	3.07	No	No	0	6	7
336	R:R:I313	R:R:V256	3.07	No	Yes	6	7	8
337	R:R:V256	R:R:Y314	10.09	Yes	Yes	6	8	9
338	R:R:I259	R:R:I313	5.89	No	No	0	6	7
339	R:R:F260	R:R:W264	6.01	No	Yes	0	9	8
340	R:R:C263	R:R:W264	3.92	No	Yes	0	7	8
341	R:R:H306	R:R:W264	6.35	No	Yes	0	9	8
342	R:R:L265	R:R:P266	3.28	No	No	0	6	9
343	R:R:L265	R:R:L269	8.3	No	No	0	6	6
344	R:R:P266	R:R:T299	3.5	No	No	0	9	6
345	R:R:L302	R:R:P266	3.28	No	No	0	7	9
346	R:R:L271	R:R:Y267	8.21	No	Yes	0	6	7
347	R:R:L296	R:R:Y267	3.52	No	Yes	0	5	7
348	R:R:T299	R:R:Y267	4.99	No	Yes	0	6	7
349	R:R:E300	R:R:Y267	7.86	No	Yes	0	5	7
350	R:R:A295	R:R:V270	3.39	No	No	0	5	4
351	R:R:L296	R:R:V270	4.47	No	No	0	5	4
352	R:R:T299	R:R:V270	3.17	No	No	0	6	4
353	R:R:L272	R:R:L276	4.15	No	No	0	5	4
354	R:R:D274	R:R:R278	10.72	Yes	Yes	1	4	4
355	R:R:L276	R:R:V281	5.96	No	No	0	4	4
356	R:R:I282	R:R:L276	5.71	No	No	0	5	4
357	R:R:E284	R:R:M277	6.77	Yes	Yes	1	3	4
358	R:R:M277	R:R:R289	4.96	Yes	Yes	1	4	3
359	R:R:I292	R:R:M277	5.83	No	Yes	0	5	4
360	R:R:T279	R:R:V281	3.17	No	No	0	1	4
361	R:R:E284	R:R:Q280	6.37	Yes	No	0	3	2
362	R:R:I282	R:R:R288	3.76	No	No	0	5	1
363	R:R:E284	R:R:R289	5.82	Yes	Yes	1	3	3
364	R:R:R288	R:R:T285	5.17	No	No	0	1	5
365	R:R:N290	R:R:R294	4.82	No	No	0	3	2
366	R:R:D297	R:R:I301	4.2	No	No	0	4	5
367	R:R:H306	R:R:N310	3.83	No	Yes	0	9	9
368	R:R:N310	R:R:Y314	4.65	Yes	Yes	0	9	9
369	R:R:I313	R:R:Y314	4.84	No	Yes	6	7	9
370	R:R:F316	R:R:L325	3.65	Yes	No	0	6	6
371	R:R:F321	R:R:K320	3.72	Yes	No	0	8	6
372	R:R:H323	R:R:K327	10.48	No	No	0	4	4
373	R:R:L63	R:R:S67	3	No	No	0	5	3
374	L:L:L7	R:R:V192	2.98	No	No	0	0	5
375	N:N:L23	N:N:V60	2.98	No	No	0	0	0
376	N:N:L64	N:N:V60	2.98	No	No	0	0	0
377	R:R:L325	R:R:V72	2.98	No	No	0	6	7
378	R:R:L124	R:R:V128	2.98	No	No	0	6	5
379	R:R:L87	R:R:T83	2.95	No	No	0	7	7
380	R:R:L238	R:R:T234	2.95	No	No	0	8	8
381	R:R:I301	R:R:I54	2.94	No	No	0	5	5
382	L:L:D54	L:L:T14	2.89	Yes	No	0	0	0
383	R:R:F316	R:R:P311	2.89	Yes	No	0	6	9
384	L:L:R2	R:R:P41	2.88	No	No	0	0	4
385	R:R:I165	R:R:L161	2.85	No	No	0	5	4
386	R:R:I213	R:R:L214	2.85	No	No	0	4	3
387	R:R:I221	R:R:L225	2.85	No	No	0	4	3
388	R:R:L95	R:R:M70	2.83	No	No	0	7	6
389	R:R:Q283	R:R:T285	2.83	No	No	0	2	5
390	L:L:A4	L:L:R2	2.77	No	No	0	0	0
391	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
392	R:R:A315	R:R:F321	2.77	No	Yes	0	7	8
393	R:R:E45	R:R:K48	2.7	No	No	0	4	4
394	R:R:E42	R:R:L44	2.65	No	No	0	4	2
395	R:R:A93	R:R:W170	2.59	No	No	0	8	9
396	R:R:R185	R:R:T116	2.59	No	No	0	4	3
397	R:R:R159	R:R:T156	2.59	Yes	No	0	3	2
398	R:R:F114	R:R:L118	2.44	Yes	No	0	6	6
399	R:R:F97	R:R:N129	2.42	Yes	No	0	6	8
400	R:R:L210	R:R:W207	2.28	No	No	0	2	3
401	N:N:F19	N:N:H16	2.26	No	No	0	0	0
402	R:R:R77	R:R:R80	2.13	No	No	0	6	7
403	R:R:R248	R:R:R322	2.13	No	No	0	7	8
404	R:R:A93	R:R:G133	1.95	No	No	0	8	9
405	R:R:A37	R:R:P38	1.87	No	Yes	0	7	7
406	R:R:A138	R:R:P223	1.87	No	Yes	0	7	9
407	N:N:G29	N:N:S28	1.86	No	No	0	0	0
408	R:R:G111	R:R:S107	1.86	No	No	0	4	5
409	R:R:G79	R:R:V78	1.84	No	No	0	6	5
410	R:R:G115	R:R:T186	1.82	No	No	0	8	4
411	R:R:G201	R:R:T204	1.82	No	No	0	4	3
412	N:N:P17	N:N:V59	1.77	No	No	0	0	0
413	R:R:G244	R:R:M243	1.75	No	Yes	0	4	4
414	R:R:G324	R:R:K327	1.74	No	No	0	5	4
415	R:R:G65	R:R:L64	1.71	No	No	0	7	4
416	R:R:G171	R:R:L174	1.71	No	No	0	4	5
417	R:R:G303	R:R:L302	1.71	No	No	0	7	7
418	L:L:D47	L:L:G48	1.68	No	No	0	0	0
419	R:R:A151	R:R:T152	1.68	No	No	0	8	5
420	N:N:K13	N:N:P14	1.67	No	No	0	0	0
421	R:R:L29	R:R:P30	1.64	No	No	0	3	3
422	R:R:L101	R:R:P102	1.64	No	No	0	8	9
423	R:R:L178	R:R:P179	1.64	No	No	0	3	8
424	R:R:L211	R:R:P179	1.64	No	No	0	4	8
425	R:R:L214	R:R:P215	1.64	No	No	0	3	5
426	L:L:S3	R:R:S193	1.63	No	No	0	0	3
427	R:R:V252	R:R:V256	1.6	No	Yes	0	7	8
428	L:L:L51	R:R:A36	1.58	No	No	0	0	5
429	R:R:A249	R:R:L238	1.58	No	No	0	7	8
430	L:L:A37	L:L:N38	1.56	No	No	0	0	0
431	N:N:A33	N:N:N34	1.56	No	No	0	0	0
432	R:R:A205	R:R:N206	1.56	No	No	0	1	1
433	R:R:A36	R:R:D35	1.54	No	No	0	5	6
434	N:N:K9	N:N:T10	1.5	No	No	0	0	0
435	R:R:G318	R:R:R322	1.5	No	No	0	7	8
436	R:R:L305	R:R:V58	1.49	No	No	0	5	7
437	R:R:L174	R:R:V128	1.49	No	No	0	5	5
438	R:R:N110	R:R:V109	1.48	No	No	0	4	4
439	R:R:K246	R:R:M243	1.44	No	Yes	0	7	4
440	R:R:I328	R:R:L71	1.43	No	No	0	5	3
441	R:R:I259	R:R:L309	1.43	No	No	0	6	6
442	R:R:I113	R:R:N110	1.42	No	No	0	3	4
443	R:R:L238	R:R:M243	1.41	No	Yes	0	8	4
444	R:R:E287	R:R:T285	1.41	No	No	0	4	5
445	L:L:D54	L:L:K56	1.38	Yes	No	0	0	0
446	R:R:L63	R:R:L95	1.38	No	No	0	5	7
447	R:R:L172	R:R:L175	1.38	No	No	0	4	4
448	R:R:L175	R:R:L178	1.38	No	No	0	4	3
449	R:R:L224	R:R:L261	1.38	Yes	No	0	7	6
450	R:R:A195	R:R:Y197	1.33	No	Yes	0	3	3
451	R:R:F220	R:R:I221	1.26	Yes	No	0	8	4
452	R:R:F59	R:R:L60	1.22	No	No	0	7	4
453	R:R:F117	R:R:L118	1.22	No	No	0	1	6
454	R:R:F316	R:R:L312	1.22	Yes	No	0	6	6
455	R:R:H247	R:R:R251	1.13	No	No	0	5	5
456	R:R:H291	R:R:R294	1.13	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E6	7.22	6	1	0
2	L:L:R8	8.34	6	1	0
3	L:L:Q10	7.1425	4	2	0
4	L:L:Y15	6.5475	4	8	0
5	L:L:F19	7.0325	4	8	0
6	L:L:F23	6.67	4	0	0
7	L:L:R28	4.816	5	2	0
8	L:L:P34	5.6975	4	0	0
9	L:L:E40	4.315	4	2	0
10	L:L:I42	4.26	4	2	0
11	L:L:D54	4.95	4	0	0
12	L:L:W59	7.404	5	0	0
13	L:L:F67	5.8125	4	9	0
14	L:L:L68	4.105	4	9	0
15	N:N:F15	4.648	5	3	0
16	N:N:I20	7.0125	4	0	0
17	N:N:E22	8.3675	4	2	0
18	N:N:R24	9.8525	4	7	0
19	N:N:E27	6.0125	4	0	0
20	N:N:L49	5.4925	4	3	0
21	N:N:D50	5.78	4	0	0
22	N:N:W55	8.968	5	3	0
23	N:N:F63	7.2175	4	10	0
24	R:R:P31	8.15	4	8	5
25	R:R:P38	4.615	4	0	7
26	R:R:Y55	5.8675	4	5	7
27	R:R:Y86	5.864	5	0	7
28	R:R:F97	4.83	4	0	6
29	R:R:K108	5.378	5	5	5
30	R:R:W112	6.17571	7	4	9
31	R:R:F114	5.82	4	4	6
32	R:R:Y131	7.365	4	0	7
33	R:R:Y145	7.358	5	15	8
34	R:R:H150	6.2475	4	15	6
35	R:R:R159	5.69	4	13	3
36	R:R:Y197	7.508	5	1	3
37	R:R:M200	6.71	4	0	5
38	R:R:R208	10.6625	4	1	4
39	R:R:R212	6.734	5	1	5
40	R:R:F220	7.285	4	0	8
41	R:R:P223	3.2125	4	0	9
42	R:R:L224	3.9	4	0	7
43	R:R:Y231	7.38667	6	6	9
44	R:R:M243	2.3575	4	0	4
45	R:R:V256	4.6375	4	6	8
46	R:R:W264	6.034	5	14	8
47	R:R:Y267	6.145	4	0	7
48	R:R:D274	9.42	4	1	4
49	R:R:M277	5.32	4	1	4
50	R:R:R278	8.15	4	1	4
51	R:R:E284	6.1075	4	1	3
52	R:R:R289	7.388	5	1	3
53	R:R:N310	5.17	4	0	9
54	R:R:Y314	7.728	5	6	9
55	R:R:F316	2.9225	4	0	6
56	R:R:F321	4.105	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E300	R:R:Y267	24.6706	7.86	No	Yes	0	5	7
2	R:R:L271	R:R:Y267	13.2966	8.21	No	Yes	0	6	7
3	R:R:L271	R:R:R212	38.6047	10.93	No	Yes	0	6	5
4	R:R:R208	R:R:R212	33.4535	3.2	Yes	Yes	1	4	5
5	R:R:R208	R:R:Y197	52.9405	18.52	Yes	Yes	1	4	3
6	R:R:V187	R:R:Y197	100	5.05	No	Yes	0	3	3
7	L:L:P34	R:R:V187	99.6479	5.3	Yes	No	0	0	3
8	L:L:G33	L:L:P34	97.6722	4.06	No	Yes	0	0	0
9	L:L:G33	L:L:H35	97.2381	3.18	No	No	0	0	0
10	L:L:H35	L:L:I30	88.8089	3.98	No	No	0	0	0
11	L:L:I30	L:L:R28	85.5925	5.01	No	Yes	2	0	0
12	R:R:L296	R:R:Y267	15.6142	3.52	No	Yes	0	5	7
13	L:L:E6	R:R:L296	18.1265	3.98	Yes	No	0	0	5
14	L:L:E6	R:R:R208	23.3341	11.63	Yes	Yes	1	0	4
15	R:R:E300	R:R:K108	20.3398	5.4	No	Yes	5	5	5
16	L:L:F19	L:L:I24	26.231	5.02	Yes	No	0	0	0
17	L:L:F67	L:L:I24	29.374	8.79	Yes	No	0	0	0
18	L:L:F67	L:L:L68	33.1339	3.65	Yes	Yes	9	0	0
19	L:L:L68	N:N:V25	39.2747	4.47	Yes	No	0	0	0
20	N:N:I37	N:N:V25	39.9634	3.07	No	No	0	0	0
21	N:N:I37	N:N:P51	40.6744	5.08	No	No	0	0	0
22	N:N:P51	N:N:T35	62.6156	3.5	No	No	0	0	0
23	N:N:S28	N:N:T35	63.2377	3.2	No	No	0	0	0
24	N:N:G29	N:N:S28	63.8564	1.86	No	No	0	0	0
25	N:N:G29	N:N:H31	65.0835	3.18	No	No	0	0	0
26	N:N:C32	N:N:H31	65.6919	7.37	No	No	0	0	0
27	N:N:C32	N:N:E36	66.1465	3.04	No	No	11	0	0
28	N:N:C7	N:N:E36	67.4967	6.08	No	No	0	0	0
29	N:N:C7	N:N:I38	68.6828	3.27	No	No	0	0	0
30	N:N:I38	N:N:R24	69.2707	3.76	No	Yes	0	0	0
31	L:L:E26	N:N:R24	70.274	15.12	No	Yes	7	0	0
32	L:L:E26	L:L:K44	72.3266	5.4	No	No	0	0	0
33	L:L:E50	L:L:K44	72.8957	12.15	No	No	0	0	0
34	L:L:E50	L:L:R28	76.9291	3.49	No	Yes	0	0	0
35	L:L:F19	L:L:W59	12.2849	7.02	Yes	Yes	0	0	0
36	N:N:F15	N:N:I20	10.1912	6.28	Yes	Yes	0	0	0
37	N:N:F15	N:N:W55	14.1204	6.01	Yes	Yes	3	0	0
38	N:N:E53	N:N:W55	19.0443	4.36	No	Yes	0	0	0
39	N:N:D50	N:N:E53	19.8578	5.2	Yes	No	0	0	0
40	N:N:D50	N:N:P51	23.0914	8.05	Yes	No	0	0	0
41	R:R:A37	R:R:P38	11.1364	1.87	No	Yes	0	7	7
42	R:R:E198	R:R:Y197	48.784	5.61	No	Yes	1	5	3
43	R:R:E198	R:R:R184	52.4739	12.79	No	No	1	5	5
44	R:R:R184	R:R:V180	51.8432	10.46	No	No	1	5	4
45	R:R:E127	R:R:V180	52.0825	9.98	No	No	0	4	4
46	R:R:E127	R:R:Y131	51.8911	8.98	No	Yes	0	4	7
47	R:R:F130	R:R:Y131	55.8117	9.28	No	Yes	0	7	7
48	R:R:F130	R:R:W264	53.3712	8.02	No	Yes	14	7	8
49	R:R:H306	R:R:W264	44.2276	6.35	No	Yes	0	9	8
50	R:R:F97	R:R:H306	26.3643	3.39	Yes	No	0	6	9
51	R:R:F97	R:R:K126	18.9605	6.2	Yes	No	0	6	6
52	R:R:K126	R:R:W104	18.2735	12.76	No	No	0	6	6
53	R:R:W104	R:R:W112	16.1166	3.75	No	Yes	4	6	9
54	R:R:K108	R:R:Y55	14.9784	7.17	Yes	Yes	5	5	7
55	R:R:I304	R:R:Y55	15.7372	7.25	No	Yes	0	7	7
56	R:R:I304	R:R:L101	12.7378	5.71	No	No	0	7	8
57	R:R:H306	R:R:N310	38.644	3.83	No	Yes	0	9	9
58	R:R:D94	R:R:N310	22.1292	8.08	No	Yes	0	9	9
59	R:R:D94	R:R:N66	21.4131	5.39	No	No	0	9	9
60	R:R:N66	R:R:P311	17.0447	6.52	No	No	0	9	9
61	R:R:F316	R:R:P311	14.064	2.89	Yes	No	0	6	9
62	R:R:F316	R:R:V69	11.0287	3.93	Yes	No	0	6	8
63	R:R:F260	R:R:W264	27.8768	6.01	No	Yes	0	9	8
64	R:R:F260	R:R:M227	42.3493	11.2	No	No	0	9	8
65	R:R:M227	R:R:Y231	31.0027	3.59	No	Yes	6	8	9
66	R:R:R144	R:R:Y231	18.711	8.23	No	Yes	0	9	9
67	R:R:I140	R:R:R144	22.4283	6.26	No	No	0	9	9
68	R:R:I140	R:R:Y86	21.1362	6.04	No	Yes	0	9	7
69	R:R:L271	R:R:Q216	26.5386	7.99	No	No	0	6	5
70	R:R:N268	R:R:Q216	26.3728	7.92	No	No	0	8	5
71	R:R:F220	R:R:N268	26.2549	16.92	Yes	No	0	8	8
72	R:R:F220	R:R:L224	27.911	3.65	Yes	Yes	0	8	7
73	R:R:F260	R:R:L224	27.5777	3.65	No	Yes	0	9	7
74	R:R:N310	R:R:Y314	20.979	4.65	Yes	Yes	0	9	9
75	R:R:R144	R:R:Y314	14.1768	6.17	No	Yes	0	9	9
76	R:R:M227	R:R:S141	10.7296	4.6	No	No	6	8	9
77	R:R:C230	R:R:S141	12.8369	5.16	No	No	0	7	9
78	R:R:C230	R:R:Y145	10.7313	6.72	No	Yes	0	7	8
79	R:R:I253	R:R:Y231	19.9604	9.67	No	Yes	0	7	9
80	R:R:I253	R:R:T234	13.8162	3.04	No	No	0	7	8
81	R:R:M209	R:R:T279	10.4886	4.52	No	No	0	3	1
82	R:R:L238	R:R:T234	11.3346	2.95	No	No	0	8	8
83	R:R:F97	R:R:L101	11.5414	7.31	Yes	No	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R2	R:R:S43	5.27	0	No	No	0	5	0	1
L:L:K5	R:R:K108	5.75	5	No	Yes	0	5	0	1
L:L:K5	R:R:D297	5.53	5	No	No	0	4	0	1
L:L:K5	R:R:E300	12.15	5	No	No	0	5	0	1
L:L:E6	R:R:R208	11.63	1	Yes	Yes	0	4	0	1
L:L:E6	R:R:R212	5.82	1	Yes	Yes	0	5	0	1
L:L:E6	R:R:D274	9.09	1	Yes	Yes	0	4	0	1
L:L:E6	R:R:R278	6.98	1	Yes	Yes	0	4	0	1
L:L:E6	R:R:L296	3.98	1	Yes	No	0	5	0	1
L:L:L7	R:R:S189	4.5	0	No	No	0	1	0	1
L:L:L7	R:R:Y197	7.03	0	No	Yes	0	3	0	1
L:L:R8	R:R:D274	11.91	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:M277	3.72	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:R278	7.46	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:R289	12.79	1	Yes	Yes	0	3	0	1
L:L:R8	R:R:D293	8.34	1	Yes	No	0	4	0	1
L:L:Q10	R:R:N191	15.85	2	Yes	No	0	2	0	1
L:L:I12	R:R:E284	5.47	1	No	Yes	0	3	0	1
L:L:I12	R:R:R289	5.01	1	No	Yes	0	3	0	1
L:L:Y15	R:R:P31	4.17	8	Yes	Yes	0	5	0	1
L:L:F19	R:R:P31	13	8	Yes	Yes	0	5	0	1
L:L:K22	R:R:T28	4.5	0	No	No	0	7	0	1
L:L:F23	R:R:P30	4.33	0	Yes	No	0	3	0	1
L:L:F23	R:R:P31	7.22	0	Yes	Yes	0	5	0	1
L:L:S32	R:R:N202	7.45	0	No	No	0	2	0	1
L:L:P34	R:R:V187	5.3	0	Yes	No	0	3	0	1
L:L:P34	R:R:D199	6.44	0	Yes	No	0	4	0	1
L:L:P34	R:R:T204	6.99	0	Yes	No	0	3	0	1
L:L:I42	R:R:P38	3.39	2	Yes	Yes	0	7	0	1
L:L:L45	R:R:P31	8.21	0	No	Yes	0	5	0	1
L:L:R49	R:R:F32	8.55	0	No	No	0	3	0	1
L:L:R49	R:R:L33	9.72	0	No	No	0	3	0	1
L:L:E50	R:R:P38	9.43	0	No	Yes	0	7	0	1
L:L:C52	R:R:P38	3.77	0	No	Yes	0	7	0	1
N:N:E22	R:R:S190	8.62	2	Yes	No	0	2	0	1
N:N:K40	R:R:S190	6.12	2	No	No	0	2	0	1
N:N:G44	R:R:Y188	7.24	0	No	No	0	1	0	1
R:R:F32	R:R:L34	3.65	0	No	No	3	2	1	2
R:R:A37	R:R:L33	3.15	0	No	No	7	3	2	1
R:R:C39	R:R:R289	8.36	0	No	Yes	8	3	2	1
R:R:E40	R:R:P41	3.14	0	No	No	4	4	2	1
R:R:N191	R:R:P41	4.89	0	No	No	2	4	1	1
R:R:V51	R:R:Y55	5.05	5	No	Yes	5	7	2	2
R:R:K108	R:R:V51	3.04	5	Yes	No	5	5	1	2
R:R:I301	R:R:V51	3.07	0	No	No	5	5	2	2
R:R:K108	R:R:Y55	7.17	5	Yes	Yes	5	7	1	2
R:R:D297	R:R:K108	5.53	5	No	Yes	4	5	1	1
R:R:E300	R:R:K108	5.4	5	No	Yes	5	5	1	1
R:R:G111	R:R:S193	3.71	0	No	No	4	3	2	1
R:R:D199	R:R:R185	9.53	0	No	No	4	4	1	2
R:R:V187	R:R:Y197	5.05	0	No	Yes	3	3	1	1
R:R:P194	R:R:Y188	8.34	0	No	No	5	1	2	1
R:R:P194	R:R:S193	3.56	0	No	No	5	3	2	1
R:R:E198	R:R:Y197	5.61	1	No	Yes	5	3	2	1
R:R:R208	R:R:Y197	18.52	1	Yes	Yes	4	3	1	1
R:R:E198	R:R:R208	9.3	1	No	Yes	5	4	2	1
R:R:M200	R:R:T204	3.01	0	Yes	No	5	3	2	1
R:R:R208	R:R:R212	3.2	1	Yes	Yes	4	5	1	1
R:R:M209	R:R:T275	3.01	0	No	No	3	4	2	2
R:R:M209	R:R:R278	7.44	0	No	Yes	3	4	2	1
R:R:L271	R:R:R212	10.93	0	No	Yes	6	5	2	1
R:R:D274	R:R:R212	5.96	1	Yes	Yes	4	5	1	1
R:R:R212	R:R:T275	7.76	1	Yes	No	5	4	1	2
R:R:L271	R:R:Y267	8.21	0	No	Yes	6	7	2	2
R:R:L296	R:R:Y267	3.52	0	No	Yes	5	7	1	2
R:R:E300	R:R:Y267	7.86	5	No	Yes	5	7	1	2
R:R:L296	R:R:V270	4.47	0	No	No	5	4	1	2
R:R:D274	R:R:R278	10.72	1	Yes	Yes	4	4	1	1
R:R:E284	R:R:M277	6.77	1	Yes	Yes	3	4	1	1
R:R:M277	R:R:R289	4.96	1	Yes	Yes	4	3	1	1
R:R:I292	R:R:M277	5.83	0	No	Yes	5	4	2	1
R:R:E284	R:R:Q280	6.37	1	Yes	No	3	2	1	2
R:R:E284	R:R:R289	5.82	1	Yes	Yes	3	3	1	1
R:R:D297	R:R:I301	4.2	5	No	No	4	5	1	2
L:L:L7	R:R:V192	2.98	0	No	No	0	5	0	1
L:L:R2	R:R:P41	2.88	0	No	No	0	4	0	1
R:R:A37	R:R:P38	1.87	0	No	Yes	7	7	2	1
R:R:G201	R:R:T204	1.82	0	No	No	4	3	2	1
R:R:L29	R:R:P30	1.64	0	No	No	3	3	2	1
L:L:S3	R:R:S193	1.63	0	No	No	0	3	0	1
L:L:L51	R:R:A36	1.58	0	No	No	0	5	0	1
R:R:A36	R:R:D35	1.54	0	No	No	5	6	1	2
R:R:A195	R:R:Y197	1.33	0	No	Yes	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XX6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	413
Number of Links	456
Number of Hubs	56
Number of Links mediated by Hubs	204
Number of Communities	15
Number of Nodes involved in Communities	79
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	111736
Length Of Smallest Path	3
Average Path Length	21.9646
Length of Longest Path	54
Minimum Path Strength	1.38
Average Path Strength	6.18399
Maximum Path Strength	16.175
Minimum Path Correlation	0.7
Average Path Correlation	0.955791
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.27273
Average % Of Corr. Nodes	53.3946
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.7782
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • protein binding • binding • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • developmental process • multicellular organismal process • head development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • midbrain development • anatomical structure development • system development • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • head development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • midbrain development • anatomical structure development • system development • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • response to stimulus • immune response • immune system process • defense response • response to stress • inflammatory response • acute inflammatory response to antigenic stimulus • acute inflammatory response • inflammatory response to antigenic stimulus • regulation of cellular process • homeostatic process • leukocyte apoptotic process • negative regulation of biological process • regulation of programmed cell death • regulation of neutrophil apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of neutrophil apoptotic process • negative regulation of cellular process • regulation of immune system process • myeloid cell homeostasis • regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of biological process • negative regulation of programmed cell death • regulation of apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • negative regulation of apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • homeostasis of number of cells • apoptotic process • programmed cell death • regulation of myeloid cell apoptotic process • neutrophil activation • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • cellular response to stimulus • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • taxis • granulocyte chemotaxis • response to chemical • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of response to stimulus • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of vascular permeability • system process • circulatory system process • positive regulation of vascular permeability • vascular process in circulatory system • blood circulation • cellular defense response • epithelium development • kidney epithelium development • metanephric tubule morphogenesis • morphogenesis of an epithelium • metanephric epithelium development • tissue development • renal system development • tissue morphogenesis • metanephros development • metanephric tubule development • epithelial tube morphogenesis • kidney development • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to interleukin-8 • response to interleukin-8 • cellular response to cytokine stimulus • interleukin-8-mediated signaling pathway • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • mast cell granule
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • mast cell granule • organelle • cytoplasm • lysosome • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • organelle membrane • secretory granule membrane • molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • G protein-coupled receptor binding • signaling receptor activator activity • protein binding • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CXCR chemokine receptor binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • interleukin-8 receptor binding • regulation of biological process • cell adhesion • regulation of cellular process • regulation of cell adhesion • biological regulation • cellular process • positive chemotaxis • chemotaxis • positive regulation of locomotion • response to stimulus • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • response to external stimulus • induction of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • response to chemical • regulation of locomotion • locomotion • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • digestive system development • animal organ development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • neutrophil activation • immune system process • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • cellular response to stimulus • neutrophil chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • biological process involved in interspecies interaction between organisms • entry of bacterium into host cell • regulation of entry of bacterium into host cell • symbiont entry into host • modulation by symbiont of entry into host • biological process involved in interaction with host • biological process involved in symbiotic interaction • regulation of biological process involved in symbiotic interaction • response to lipid • response to other organism • cellular response to lipopolysaccharide • response to oxygen-containing compound • cellular response to molecule of bacterial origin • response to lipopolysaccharide • cellular response to oxygen-containing compound • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • cellular response to lipid • response to external biotic stimulus • response to molecule of bacterial origin • regulation of cell motility • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of immune system process • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of granulocyte chemotaxis • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • response to fibroblast growth factor • cellular response to endogenous stimulus • cellular response to growth factor stimulus • response to endogenous stimulus • response to growth factor • cellular response to fibroblast growth factor stimulus • regulation of cell adhesion molecule production • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell adhesion molecule production • cell adhesion molecule production • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • humoral immune response • defense response • immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • inflammatory response • G protein-coupled receptor signaling pathway • regulation of signaling • negative regulation of signaling • negative regulation of response to stimulus • regulation of signal transduction • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • regulation of single stranded viral RNA replication via double stranded DNA intermediate • RNA metabolic process • viral life cycle • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • regulation of RNA metabolic process • viral RNA genome replication • viral process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • primary metabolic process • nucleobase-containing compound biosynthetic process • single stranded viral RNA replication via double stranded DNA intermediate • nucleic acid metabolic process • regulation of viral life cycle • regulation of viral process • viral genome replication • regulation of viral genome replication • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • cellular response to interleukin-1 • response to interleukin-1 • cellular response to stress • response to endoplasmic reticulum stress • extracellular region • extracellular space • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activity • mu-type opioid receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • heart contraction • blood circulation • behavior • locomotory behavior • secretion • export from cell • membrane docking • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Interleukin 8-like chemokines • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Interleukin 8-like chemokines • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XX6_nogp_Chain_R T L P P F L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	To be published
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	To be published
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	To be published
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	To be published
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	To be published
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	To be published
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	To be published
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	To be published
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	To be published
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	To be published
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	To be published
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	To be published
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	To be published
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	To be published
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	To be published
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	To be published
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	To be published
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	To be published
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	10.1038/s41586-020-2492-5

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