psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R27	R:R:S43	5.27	No	No	0	4	5
2	L:L:K30	R:R:K108	5.75	No	Yes	5	1	5
3	L:L:K30	R:R:D297	5.53	No	No	5	1	4
4	L:L:K30	R:R:E300	12.15	No	No	5	1	5
5	L:L:E31	L:L:R33	5.82	Yes	Yes	1	7	8
6	L:L:E31	R:R:R208	11.63	Yes	Yes	1	7	4
7	L:L:E31	R:R:R212	5.82	Yes	Yes	1	7	5
8	L:L:E31	R:R:D274	9.09	Yes	Yes	1	7	4
9	L:L:E31	R:R:R278	6.98	Yes	Yes	1	7	4
10	L:L:E31	R:R:L296	3.98	Yes	No	0	7	5
11	L:L:L32	R:R:S189	4.5	No	No	0	8	1
12	L:L:L32	R:R:Y197	7.03	No	Yes	0	8	3
13	L:L:R33	R:R:D274	11.91	Yes	Yes	1	8	4
14	L:L:R33	R:R:M277	3.72	Yes	Yes	1	8	4
15	L:L:R33	R:R:R278	7.46	Yes	Yes	1	8	4
16	L:L:R33	R:R:R289	12.79	Yes	Yes	1	8	3
17	L:L:R33	R:R:D293	8.34	Yes	No	0	8	4
18	L:L:C34	L:L:C61	7.28	No	No	2	9	9
19	L:L:C34	L:L:E65	3.04	No	Yes	2	9	9
20	L:L:Q35	L:L:R53	3.5	Yes	Yes	2	4	4
21	L:L:E65	L:L:Q35	5.1	Yes	Yes	2	9	4
22	L:L:I67	L:L:Q35	4.12	Yes	Yes	2	9	4
23	L:L:Q35	R:R:N191	15.85	Yes	No	0	4	2
24	L:L:C36	L:L:E65	6.08	No	Yes	0	9	9
25	L:L:C36	L:L:I67	3.27	No	Yes	0	9	9
26	L:L:C36	L:L:C77	7.28	No	No	0	9	9
27	L:L:I37	R:R:E284	5.47	No	Yes	1	5	3
28	L:L:I37	R:R:R289	5.01	No	Yes	1	5	3
29	L:L:K42	L:L:Y40	9.55	No	Yes	0	3	4
30	L:L:F44	L:L:Y40	3.09	Yes	Yes	8	8	4
31	L:L:L76	L:L:Y40	9.38	No	Yes	0	4	4
32	L:L:Y40	R:R:P31	4.17	Yes	Yes	8	4	5
33	L:L:P43	L:L:W84	13.51	No	Yes	0	5	3
34	L:L:F44	L:L:I49	5.02	Yes	No	0	8	9
35	L:L:F44	L:L:W84	7.02	Yes	Yes	0	8	3
36	L:L:F44	R:R:P31	13	Yes	Yes	8	8	5
37	L:L:H45	L:L:P46	13.73	No	No	0	6	5
38	L:L:H45	L:L:K47	11.79	No	No	0	6	7
39	L:L:K91	L:L:P46	5.02	No	No	0	4	5
40	L:L:F48	L:L:K47	11.17	Yes	No	0	3	7
41	L:L:K47	R:R:T28	4.5	No	No	0	7	7
42	L:L:F48	L:L:S71	3.96	Yes	No	0	3	7
43	L:L:F48	R:R:P30	4.33	Yes	No	0	3	3
44	L:L:F48	R:R:P31	7.22	Yes	Yes	0	3	5
45	L:L:I49	L:L:V68	3.07	No	No	0	9	8
46	L:L:F92	L:L:I49	8.79	Yes	No	0	6	9
47	L:L:K50	N:N:E56	4.05	No	Yes	0	4	4
48	L:L:E51	L:L:K69	5.4	No	No	0	5	8
49	L:L:E51	N:N:R53	15.12	No	Yes	7	5	4
50	L:L:E51	N:N:I55	15.03	No	No	7	5	6
51	L:L:L52	L:L:V54	4.47	No	No	0	7	5
52	L:L:F92	L:L:L52	7.31	Yes	No	9	6	7
53	L:L:L52	L:L:L93	4.15	No	Yes	9	7	6
54	L:L:I55	L:L:R53	5.01	No	Yes	2	6	4
55	L:L:I67	L:L:R53	6.26	Yes	Yes	2	9	4
56	L:L:E75	L:L:R53	3.49	No	Yes	0	4	4
57	L:L:R53	N:N:E51	5.82	Yes	Yes	2	4	5
58	L:L:I66	L:L:V54	3.07	No	No	0	9	5
59	L:L:H60	L:L:I55	3.98	No	No	0	8	6
60	L:L:I55	N:N:E51	10.93	No	Yes	2	6	5
61	L:L:E56	N:N:K50	5.4	No	No	0	4	4
62	L:L:E56	N:N:F92	3.5	No	Yes	10	4	6
63	L:L:E56	N:N:R95	12.79	No	No	10	4	3
64	L:L:S57	L:L:T64	3.2	No	No	0	6	6
65	L:L:S57	R:R:N202	7.45	No	No	0	6	2
66	L:L:G58	L:L:P59	4.06	No	Yes	0	8	7
67	L:L:G58	L:L:H60	3.18	No	No	0	8	8
68	L:L:P59	R:R:V187	5.3	Yes	No	0	7	3
69	L:L:P59	R:R:D199	6.44	Yes	No	0	7	4
70	L:L:P59	R:R:T204	6.99	Yes	No	0	7	3
71	L:L:C61	L:L:H60	4.42	No	No	0	9	8
72	L:L:C61	L:L:E65	3.04	No	Yes	2	9	9
73	L:L:P80	L:L:T64	3.5	No	No	0	9	6
74	L:L:T64	N:N:A96	3.36	No	No	0	6	4
75	L:L:I66	L:L:L78	5.71	No	No	0	9	9
76	L:L:I66	L:L:V89	3.07	No	No	0	9	5
77	L:L:I67	R:R:P38	3.39	Yes	Yes	0	9	7
78	L:L:L78	L:L:V68	8.94	No	No	0	9	8
79	L:L:E75	L:L:K69	12.15	No	No	0	4	8
80	L:L:L70	L:L:L76	4.15	No	No	0	7	4
81	L:L:L70	R:R:P31	8.21	No	Yes	0	7	5
82	L:L:D72	L:L:R74	22.63	No	No	0	4	2
83	L:L:R74	R:R:F32	8.55	No	No	0	2	3
84	L:L:R74	R:R:L33	9.72	No	No	0	2	3
85	L:L:E75	R:R:P38	9.43	No	Yes	0	4	7
86	L:L:C77	R:R:P38	3.77	No	Yes	0	9	7
87	L:L:L78	L:L:V85	5.96	No	No	0	9	8
88	L:L:D79	L:L:P80	6.44	Yes	No	0	6	9
89	L:L:D79	L:L:E82	9.09	Yes	No	0	6	7
90	L:L:E82	L:L:N83	3.94	No	No	0	7	4
91	L:L:E82	L:L:W84	5.45	No	Yes	0	7	3
92	L:L:V85	L:L:W84	7.36	No	Yes	0	8	3
93	L:L:V88	L:L:W84	3.68	No	Yes	0	6	3
94	L:L:Q86	N:N:E97	5.1	No	No	0	7	6
95	L:L:F92	L:L:L93	3.65	Yes	Yes	9	6	6
96	L:L:F92	N:N:E56	3.5	Yes	Yes	0	6	4
97	L:L:L93	N:N:V54	4.47	Yes	No	0	6	5
98	L:L:L93	N:N:L93	4.15	Yes	No	0	6	6
99	L:L:K94	L:L:N98	8.39	No	No	0	5	4
100	L:L:R95	N:N:E56	10.47	No	Yes	0	3	4
101	L:L:A96	N:N:E56	6.03	No	Yes	0	4	4
102	L:L:E97	N:N:Q86	16.57	No	No	0	6	7
103	N:N:C34	N:N:C61	7.28	No	No	11	9	9
104	N:N:C34	N:N:E65	6.08	No	No	11	9	9
105	N:N:Q35	N:N:R53	10.51	No	Yes	7	4	4
106	N:N:I55	N:N:Q35	4.12	No	No	7	6	4
107	N:N:C36	N:N:E65	6.08	No	No	0	9	9
108	N:N:C36	N:N:I67	3.27	No	No	0	9	9
109	N:N:C36	N:N:C77	7.28	No	No	0	9	9
110	N:N:D79	N:N:T39	4.34	Yes	No	0	6	8
111	N:N:R74	N:N:Y40	3.09	No	No	0	2	4
112	N:N:L76	N:N:Y40	12.89	No	No	0	4	4
113	N:N:P43	N:N:W84	17.57	No	Yes	0	5	3
114	N:N:F44	N:N:I49	6.28	Yes	Yes	0	8	9
115	N:N:F44	N:N:L70	3.65	Yes	No	3	8	7
116	N:N:F44	N:N:L76	3.65	Yes	No	0	8	4
117	N:N:F44	N:N:L78	3.65	Yes	Yes	3	8	9
118	N:N:F44	N:N:W84	6.01	Yes	Yes	3	8	3
119	N:N:H45	N:N:P46	12.2	No	No	0	6	5
120	N:N:H45	N:N:K47	6.55	No	No	0	6	7
121	N:N:K91	N:N:P46	8.36	No	No	0	4	5
122	N:N:I49	N:N:V68	6.14	Yes	No	0	9	8
123	N:N:I49	N:N:V88	3.07	Yes	No	0	9	6
124	N:N:F92	N:N:I49	12.56	Yes	Yes	0	6	9
125	N:N:K50	N:N:S71	7.65	No	No	0	4	7
126	N:N:E51	N:N:K69	8.1	Yes	No	2	5	8
127	N:N:E51	R:R:S190	8.62	Yes	No	2	5	2
128	N:N:F92	N:N:L52	8.53	Yes	No	0	6	7
129	N:N:I55	N:N:R53	10.02	No	Yes	7	6	4
130	N:N:I67	N:N:R53	3.76	No	Yes	0	9	4
131	N:N:I66	N:N:V54	3.07	No	No	0	9	5
132	N:N:S57	N:N:T64	3.2	No	No	0	6	6
133	N:N:G58	N:N:P59	4.06	No	No	0	8	7
134	N:N:G58	N:N:H60	3.18	No	No	0	8	8
135	N:N:C61	N:N:H60	7.37	No	No	0	9	8
136	N:N:C61	N:N:E65	3.04	No	No	11	9	9
137	N:N:P80	N:N:T64	3.5	No	No	0	9	6
138	N:N:I66	N:N:P80	5.08	No	No	0	9	9
139	N:N:L78	N:N:V68	5.96	Yes	No	0	9	8
140	N:N:E75	N:N:K69	12.15	No	No	0	4	8
141	N:N:K69	R:R:S190	6.12	No	No	2	8	2
142	N:N:D72	N:N:L70	5.43	No	No	3	4	7
143	N:N:L70	N:N:R74	4.86	No	No	3	7	2
144	N:N:D72	N:N:R74	22.63	No	No	3	4	2
145	N:N:G73	R:R:Y188	7.24	No	No	0	7	1
146	N:N:L78	N:N:W84	3.42	Yes	Yes	3	9	3
147	N:N:L78	N:N:V85	8.94	Yes	No	3	9	8
148	N:N:D79	N:N:P80	8.05	Yes	No	0	6	9
149	N:N:D79	N:N:K81	5.53	Yes	No	0	6	2
150	N:N:D79	N:N:E82	5.2	Yes	No	0	6	7
151	N:N:E82	N:N:W84	4.36	No	Yes	0	7	3
152	N:N:N83	N:N:R87	16.87	No	No	0	4	4
153	N:N:V85	N:N:W84	13.48	No	Yes	3	8	3
154	N:N:F92	N:N:R95	4.28	Yes	No	10	6	3
155	N:N:E97	N:N:K94	10.8	No	No	0	6	5
156	N:N:K94	N:N:N98	4.2	No	No	0	5	4
157	R:R:F32	R:R:L34	3.65	No	No	0	3	2
158	R:R:A37	R:R:L33	3.15	No	No	0	7	3
159	R:R:C286	R:R:C39	7.28	No	No	0	6	8
160	R:R:C39	R:R:R289	8.36	No	Yes	0	8	3
161	R:R:E40	R:R:P41	3.14	No	No	0	4	4
162	R:R:N191	R:R:P41	4.89	No	No	0	2	4
163	R:R:E42	R:R:N290	3.94	No	No	0	4	3
164	R:R:L44	R:R:N47	4.12	No	No	0	2	4
165	R:R:K48	R:R:V109	9.11	No	No	0	4	4
166	R:R:I53	R:R:Y49	7.25	No	No	0	5	2
167	R:R:F50	R:R:I54	12.56	No	No	0	5	5
168	R:R:V51	R:R:Y55	5.05	No	Yes	5	5	7
169	R:R:K108	R:R:V51	3.04	Yes	No	5	5	5
170	R:R:I301	R:R:V51	3.07	No	No	0	5	5
171	R:R:V109	R:R:V52	4.81	No	No	0	4	5
172	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
173	R:R:K108	R:R:Y55	7.17	Yes	Yes	5	5	7
174	R:R:I304	R:R:Y55	7.25	No	Yes	0	7	7
175	R:R:L57	R:R:L61	6.92	No	No	0	5	5
176	R:R:I304	R:R:V58	4.61	No	No	0	7	7
177	R:R:C308	R:R:V58	5.12	No	No	0	7	7
178	R:R:F59	R:R:P102	14.45	No	No	0	7	9
179	R:R:C308	R:R:L61	3.17	No	No	0	7	5
180	R:R:A98	R:R:S62	3.42	No	No	0	5	8
181	R:R:S307	R:R:S62	6.52	No	No	0	8	8
182	R:R:C308	R:R:S62	5.16	No	No	0	7	8
183	R:R:L64	R:R:L68	4.15	No	No	0	4	6
184	R:R:G65	R:R:P311	4.06	No	No	0	7	9
185	R:R:D94	R:R:N66	5.39	No	No	0	9	9
186	R:R:L95	R:R:N66	5.49	No	No	0	7	9
187	R:R:N66	R:R:P311	6.52	No	No	0	9	9
188	R:R:A91	R:R:V69	3.39	No	No	0	8	8
189	R:R:A315	R:R:V69	3.39	No	No	0	7	8
190	R:R:F316	R:R:V69	3.93	Yes	No	0	6	8
191	R:R:L92	R:R:M70	4.24	No	No	0	6	6
192	R:R:I73	R:R:L88	5.71	No	No	0	6	5
193	R:R:F321	R:R:I73	6.28	Yes	No	0	8	6
194	R:R:L74	R:R:R80	3.64	No	No	0	2	7
195	R:R:L74	R:R:L88	6.92	No	No	0	2	5
196	R:R:I328	R:R:Y75	10.88	No	No	0	5	4
197	R:R:D84	R:R:S81	10.31	No	No	12	8	7
198	R:R:K320	R:R:S81	3.06	No	No	12	6	7
199	R:R:D143	R:R:V82	5.84	No	No	13	8	7
200	R:R:R159	R:R:V82	3.92	Yes	No	13	3	7
201	R:R:V162	R:R:V82	3.21	No	No	0	7	7
202	R:R:D84	R:R:K320	5.53	No	No	12	8	6
203	R:R:V162	R:R:V85	8.02	No	No	0	7	6
204	R:R:C139	R:R:Y86	4.03	No	Yes	0	5	7
205	R:R:I140	R:R:Y86	6.04	No	Yes	0	9	7
206	R:R:D143	R:R:Y86	8.05	No	Yes	0	8	7
207	R:R:V162	R:R:Y86	7.57	No	Yes	0	7	7
208	R:R:I165	R:R:Y86	3.63	No	Yes	0	5	7
209	R:R:F321	R:R:L87	3.65	Yes	No	0	8	7
210	R:R:L136	R:R:N89	4.12	No	No	0	8	9
211	R:R:C166	R:R:N89	11.02	No	No	0	7	9
212	R:R:N89	R:R:W170	5.65	No	No	0	9	9
213	R:R:L136	R:R:L90	5.54	No	No	0	8	9
214	R:R:L137	R:R:L90	5.54	No	No	0	8	9
215	R:R:L90	R:R:N310	4.12	No	Yes	0	9	9
216	R:R:D94	R:R:N310	8.08	No	Yes	0	9	9
217	R:R:L96	R:R:N129	12.36	No	No	0	7	8
218	R:R:F97	R:R:L101	7.31	Yes	No	0	6	8
219	R:R:F97	R:R:K126	6.2	Yes	No	0	6	6
220	R:R:F97	R:R:H306	3.39	Yes	No	0	6	9
221	R:R:L125	R:R:T100	4.42	No	No	0	4	7
222	R:R:I304	R:R:L101	5.71	No	No	0	7	8
223	R:R:I103	R:R:W112	4.7	No	Yes	4	6	9
224	R:R:F114	R:R:I103	10.05	Yes	No	4	6	6
225	R:R:I103	R:R:V122	4.61	No	No	4	6	5
226	R:R:W104	R:R:W112	3.75	No	Yes	4	6	9
227	R:R:V122	R:R:W104	3.68	No	No	4	5	6
228	R:R:K126	R:R:W104	12.76	No	No	0	6	6
229	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
230	R:R:D297	R:R:K108	5.53	No	Yes	5	4	5
231	R:R:E300	R:R:K108	5.4	No	Yes	5	5	5
232	R:R:G111	R:R:S193	3.71	No	No	0	4	3
233	R:R:F114	R:R:W112	8.02	Yes	Yes	4	6	9
234	R:R:C119	R:R:W112	6.53	No	Yes	4	9	9
235	R:R:V122	R:R:W112	3.68	No	Yes	4	5	9
236	R:R:C196	R:R:W112	9.14	No	Yes	4	9	9
237	R:R:I113	R:R:P194	3.39	No	No	0	3	5
238	R:R:K120	R:R:T116	4.5	No	No	0	7	3
239	R:R:T116	R:R:T186	4.71	No	No	0	3	4
240	R:R:F117	R:R:V121	7.87	No	No	0	1	5
241	R:R:C119	R:R:C196	7.28	No	No	4	9	9
242	R:R:S123	R:R:V180	3.23	No	No	1	5	4
243	R:R:R184	R:R:S123	10.54	No	No	1	5	5
244	R:R:L124	R:R:L181	4.15	No	No	0	6	5
245	R:R:L125	R:R:N129	4.12	No	No	0	4	8
246	R:R:E127	R:R:Y131	8.98	No	Yes	0	4	7
247	R:R:A177	R:R:E127	4.53	No	No	0	7	4
248	R:R:E127	R:R:V180	9.98	No	No	0	4	4
249	R:R:A177	R:R:V128	3.39	No	No	0	7	5
250	R:R:F130	R:R:Y131	9.28	No	Yes	0	7	7
251	R:R:F130	R:R:I134	6.28	No	No	14	7	8
252	R:R:F130	R:R:W264	8.02	No	Yes	14	7	8
253	R:R:L176	R:R:Y131	7.03	No	Yes	0	4	7
254	R:R:P215	R:R:Y131	4.17	No	Yes	0	5	7
255	R:R:S132	R:R:W170	16.06	No	No	0	6	9
256	R:R:S132	R:R:S173	6.52	No	No	0	6	7
257	R:R:I134	R:R:P223	3.39	No	Yes	0	8	9
258	R:R:I134	R:R:W264	5.87	No	Yes	14	8	8
259	R:R:I169	R:R:L135	8.56	No	No	0	6	6
260	R:R:L137	R:R:Y314	12.89	No	Yes	0	8	9
261	R:R:C139	R:R:I169	3.27	No	No	0	5	6
262	R:R:I140	R:R:R144	6.26	No	No	0	9	9
263	R:R:M227	R:R:S141	4.6	No	No	6	8	9
264	R:R:C230	R:R:S141	5.16	No	No	0	7	9
265	R:R:S141	R:R:Y231	13.99	No	Yes	6	9	9
266	R:R:C230	R:R:V142	3.42	No	No	0	7	6
267	R:R:D143	R:R:R159	10.72	No	Yes	13	8	3
268	R:R:R144	R:R:Y231	8.23	No	Yes	0	9	9
269	R:R:R144	R:R:Y314	6.17	No	Yes	0	9	9
270	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
271	R:R:V149	R:R:Y145	12.62	No	Yes	15	7	8
272	R:R:H150	R:R:Y145	9.8	Yes	Yes	15	6	8
273	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
274	R:R:F233	R:R:Y145	4.13	No	Yes	0	4	8
275	R:R:A147	R:R:R159	5.53	No	Yes	0	8	3
276	R:R:I148	R:R:T234	6.08	No	No	0	8	8
277	R:R:H150	R:R:V149	5.54	Yes	No	15	6	7
278	R:R:T237	R:R:V149	7.93	No	No	0	5	7
279	R:R:H150	R:R:R153	4.51	Yes	No	0	6	5
280	R:R:H150	R:R:L155	5.14	Yes	No	0	6	4
281	R:R:K158	R:R:L155	7.05	No	No	0	6	4
282	R:R:Q157	R:R:T156	5.67	No	No	0	7	2
283	R:R:Q157	R:R:Y160	5.64	No	No	0	7	5
284	R:R:F164	R:R:K163	4.96	No	No	0	3	4
285	R:R:L172	R:R:L176	5.54	No	No	0	4	4
286	R:R:F218	R:R:L176	3.65	No	No	0	4	4
287	R:R:R184	R:R:V180	10.46	No	No	1	5	4
288	R:R:F183	R:R:L182	6.09	No	No	0	5	4
289	R:R:F183	R:R:M200	11.2	No	Yes	0	5	5
290	R:R:E198	R:R:R184	12.79	No	No	1	5	5
291	R:R:D199	R:R:R185	9.53	No	No	0	4	4
292	R:R:V187	R:R:Y197	5.05	No	Yes	0	3	3
293	R:R:P194	R:R:Y188	8.34	No	No	0	5	1
294	R:R:P194	R:R:S193	3.56	No	No	0	5	3
295	R:R:E198	R:R:Y197	5.61	No	Yes	1	5	3
296	R:R:R208	R:R:Y197	18.52	Yes	Yes	1	4	3
297	R:R:E198	R:R:R208	9.3	No	Yes	1	5	4
298	R:R:M200	R:R:T204	3.01	Yes	No	0	5	3
299	R:R:M200	R:R:W207	6.98	Yes	No	0	5	3
300	R:R:L211	R:R:M200	5.65	No	Yes	0	4	5
301	R:R:N203	R:R:N206	13.62	No	No	0	4	1
302	R:R:N203	R:R:W207	3.39	No	No	0	4	3
303	R:R:R208	R:R:R212	3.2	Yes	Yes	1	4	5
304	R:R:M209	R:R:T275	3.01	No	No	0	3	4
305	R:R:M209	R:R:R278	7.44	No	Yes	0	3	4
306	R:R:M209	R:R:T279	4.52	No	No	0	3	1
307	R:R:L271	R:R:R212	10.93	No	Yes	0	6	5
308	R:R:D274	R:R:R212	5.96	Yes	Yes	1	4	5
309	R:R:R212	R:R:T275	7.76	Yes	No	0	5	4
310	R:R:N268	R:R:Q216	7.92	No	No	0	8	5
311	R:R:L271	R:R:Q216	7.99	No	No	0	6	5
312	R:R:F218	R:R:S217	6.61	No	No	0	4	4
313	R:R:G219	R:R:P223	4.06	No	Yes	0	5	9
314	R:R:F220	R:R:L224	3.65	Yes	Yes	0	8	7
315	R:R:F220	R:R:L265	7.31	Yes	No	0	8	6
316	R:R:F220	R:R:N268	16.92	Yes	No	0	8	8
317	R:R:P223	R:R:V222	3.53	Yes	No	0	9	5
318	R:R:I226	R:R:V222	3.07	No	No	0	6	5
319	R:R:L224	R:R:L228	6.92	Yes	No	0	7	4
320	R:R:F260	R:R:L224	3.65	No	Yes	0	9	7
321	R:R:M227	R:R:Y231	3.59	No	Yes	6	8	9
322	R:R:F260	R:R:M227	11.2	No	No	0	9	8
323	R:R:F229	R:R:F233	12.86	No	No	0	4	4
324	R:R:I253	R:R:Y231	9.67	No	Yes	0	7	9
325	R:R:V256	R:R:Y231	3.79	Yes	Yes	6	8	9
326	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
327	R:R:I253	R:R:T234	3.04	No	No	0	7	8
328	R:R:L235	R:R:M250	4.24	No	No	0	4	5
329	R:R:I253	R:R:L235	9.99	No	No	0	7	4
330	R:R:F254	R:R:L235	3.65	No	No	0	4	4
331	R:R:F239	R:R:M250	3.73	No	No	0	5	5
332	R:R:A241	R:R:M243	4.83	No	Yes	0	3	4
333	R:R:G244	R:R:Q245	3.29	No	No	0	4	4
334	R:R:H247	R:R:K246	9.17	No	No	0	5	7
335	R:R:I317	R:R:V252	3.07	No	No	0	6	7
336	R:R:I313	R:R:V256	3.07	No	Yes	6	7	8
337	R:R:V256	R:R:Y314	10.09	Yes	Yes	6	8	9
338	R:R:I259	R:R:I313	5.89	No	No	0	6	7
339	R:R:F260	R:R:W264	6.01	No	Yes	0	9	8
340	R:R:C263	R:R:W264	3.92	No	Yes	0	7	8
341	R:R:H306	R:R:W264	6.35	No	Yes	0	9	8
342	R:R:L265	R:R:P266	3.28	No	No	0	6	9
343	R:R:L265	R:R:L269	8.3	No	No	0	6	6
344	R:R:P266	R:R:T299	3.5	No	No	0	9	6
345	R:R:L302	R:R:P266	3.28	No	No	0	7	9
346	R:R:L271	R:R:Y267	8.21	No	Yes	0	6	7
347	R:R:L296	R:R:Y267	3.52	No	Yes	0	5	7
348	R:R:T299	R:R:Y267	4.99	No	Yes	0	6	7
349	R:R:E300	R:R:Y267	7.86	No	Yes	0	5	7
350	R:R:A295	R:R:V270	3.39	No	No	0	5	4
351	R:R:L296	R:R:V270	4.47	No	No	0	5	4
352	R:R:T299	R:R:V270	3.17	No	No	0	6	4
353	R:R:L272	R:R:L276	4.15	No	No	0	5	4
354	R:R:D274	R:R:R278	10.72	Yes	Yes	1	4	4
355	R:R:L276	R:R:V281	5.96	No	No	0	4	4
356	R:R:I282	R:R:L276	5.71	No	No	0	5	4
357	R:R:E284	R:R:M277	6.77	Yes	Yes	1	3	4
358	R:R:M277	R:R:R289	4.96	Yes	Yes	1	4	3
359	R:R:I292	R:R:M277	5.83	No	Yes	0	5	4
360	R:R:T279	R:R:V281	3.17	No	No	0	1	4
361	R:R:E284	R:R:Q280	6.37	Yes	No	0	3	2
362	R:R:I282	R:R:R288	3.76	No	No	0	5	1
363	R:R:E284	R:R:R289	5.82	Yes	Yes	1	3	3
364	R:R:R288	R:R:T285	5.17	No	No	0	1	5
365	R:R:N290	R:R:R294	4.82	No	No	0	3	2
366	R:R:D297	R:R:I301	4.2	No	No	0	4	5
367	R:R:H306	R:R:N310	3.83	No	Yes	0	9	9
368	R:R:N310	R:R:Y314	4.65	Yes	Yes	0	9	9
369	R:R:I313	R:R:Y314	4.84	No	Yes	6	7	9
370	R:R:F316	R:R:L325	3.65	Yes	No	0	6	6
371	R:R:F321	R:R:K320	3.72	Yes	No	0	8	6
372	R:R:H323	R:R:K327	10.48	No	No	0	4	4
373	R:R:L63	R:R:S67	3	No	No	0	5	3
374	L:L:L32	R:R:V192	2.98	No	No	0	8	5
375	N:N:L52	N:N:V89	2.98	No	No	0	7	5
376	N:N:L93	N:N:V89	2.98	No	No	0	6	5
377	R:R:L325	R:R:V72	2.98	No	No	0	6	7
378	R:R:L124	R:R:V128	2.98	No	No	0	6	5
379	R:R:L87	R:R:T83	2.95	No	No	0	7	7
380	R:R:L238	R:R:T234	2.95	No	No	0	8	8
381	R:R:I301	R:R:I54	2.94	No	No	0	5	5
382	L:L:D79	L:L:T39	2.89	Yes	No	0	6	8
383	R:R:F316	R:R:P311	2.89	Yes	No	0	6	9
384	L:L:R27	R:R:P41	2.88	No	No	0	4	4
385	R:R:I165	R:R:L161	2.85	No	No	0	5	4
386	R:R:I213	R:R:L214	2.85	No	No	0	4	3
387	R:R:I221	R:R:L225	2.85	No	No	0	4	3
388	R:R:L95	R:R:M70	2.83	No	No	0	7	6
389	R:R:Q283	R:R:T285	2.83	No	No	0	2	5
390	L:L:A29	L:L:R27	2.77	No	No	0	2	4
391	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
392	R:R:A315	R:R:F321	2.77	No	Yes	0	7	8
393	R:R:E45	R:R:K48	2.7	No	No	0	4	4
394	R:R:E42	R:R:L44	2.65	No	No	0	4	2
395	R:R:A93	R:R:W170	2.59	No	No	0	8	9
396	R:R:R185	R:R:T116	2.59	No	No	0	4	3
397	R:R:R159	R:R:T156	2.59	Yes	No	0	3	2
398	R:R:F114	R:R:L118	2.44	Yes	No	0	6	6
399	R:R:F97	R:R:N129	2.42	Yes	No	0	6	8
400	R:R:L210	R:R:W207	2.28	No	No	0	2	3
401	N:N:F48	N:N:H45	2.26	No	No	0	3	6
402	R:R:R77	R:R:R80	2.13	No	No	0	6	7
403	R:R:R248	R:R:R322	2.13	No	No	0	7	8
404	R:R:A93	R:R:G133	1.95	No	No	0	8	9
405	R:R:A37	R:R:P38	1.87	No	Yes	0	7	7
406	R:R:A138	R:R:P223	1.87	No	Yes	0	7	9
407	N:N:G58	N:N:S57	1.86	No	No	0	8	6
408	R:R:G111	R:R:S107	1.86	No	No	0	4	5
409	R:R:G79	R:R:V78	1.84	No	No	0	6	5
410	R:R:G115	R:R:T186	1.82	No	No	0	8	4
411	R:R:G201	R:R:T204	1.82	No	No	0	4	3
412	N:N:P46	N:N:V88	1.77	No	No	0	5	6
413	R:R:G244	R:R:M243	1.75	No	Yes	0	4	4
414	R:R:G324	R:R:K327	1.74	No	No	0	5	4
415	R:R:G65	R:R:L64	1.71	No	No	0	7	4
416	R:R:G171	R:R:L174	1.71	No	No	0	4	5
417	R:R:G303	R:R:L302	1.71	No	No	0	7	7
418	L:L:D72	L:L:G73	1.68	No	No	0	4	7
419	R:R:A151	R:R:T152	1.68	No	No	0	8	5
420	N:N:K42	N:N:P43	1.67	No	No	0	3	5
421	R:R:L29	R:R:P30	1.64	No	No	0	3	3
422	R:R:L101	R:R:P102	1.64	No	No	0	8	9
423	R:R:L178	R:R:P179	1.64	No	No	0	3	8
424	R:R:L211	R:R:P179	1.64	No	No	0	4	8
425	R:R:L214	R:R:P215	1.64	No	No	0	3	5
426	L:L:S28	R:R:S193	1.63	No	No	0	1	3
427	R:R:V252	R:R:V256	1.6	No	Yes	0	7	8
428	L:L:L76	R:R:A36	1.58	No	No	0	4	5
429	R:R:A249	R:R:L238	1.58	No	No	0	7	8
430	L:L:A62	L:L:N63	1.56	No	No	0	2	5
431	N:N:A62	N:N:N63	1.56	No	No	0	2	5
432	R:R:A205	R:R:N206	1.56	No	No	0	1	1
433	R:R:A36	R:R:D35	1.54	No	No	0	5	6
434	N:N:K38	N:N:T39	1.5	No	No	0	4	8
435	R:R:G318	R:R:R322	1.5	No	No	0	7	8
436	R:R:L305	R:R:V58	1.49	No	No	0	5	7
437	R:R:L174	R:R:V128	1.49	No	No	0	5	5
438	R:R:N110	R:R:V109	1.48	No	No	0	4	4
439	R:R:K246	R:R:M243	1.44	No	Yes	0	7	4
440	R:R:I328	R:R:L71	1.43	No	No	0	5	3
441	R:R:I259	R:R:L309	1.43	No	No	0	6	6
442	R:R:I113	R:R:N110	1.42	No	No	0	3	4
443	R:R:L238	R:R:M243	1.41	No	Yes	0	8	4
444	R:R:E287	R:R:T285	1.41	No	No	0	4	5
445	L:L:D79	L:L:K81	1.38	Yes	No	0	6	2
446	R:R:L63	R:R:L95	1.38	No	No	0	5	7
447	R:R:L172	R:R:L175	1.38	No	No	0	4	4
448	R:R:L175	R:R:L178	1.38	No	No	0	4	3
449	R:R:L224	R:R:L261	1.38	Yes	No	0	7	6
450	R:R:A195	R:R:Y197	1.33	No	Yes	0	3	3
451	R:R:F220	R:R:I221	1.26	Yes	No	0	8	4
452	R:R:F59	R:R:L60	1.22	No	No	0	7	4
453	R:R:F117	R:R:L118	1.22	No	No	0	1	6
454	R:R:F316	R:R:L312	1.22	Yes	No	0	6	6
455	R:R:H247	R:R:R251	1.13	No	No	0	5	5
456	R:R:H291	R:R:R294	1.13	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E31	7.22	6	1	7
2	L:L:R33	8.34	6	1	8
3	L:L:Q35	7.1425	4	2	4
4	L:L:Y40	6.5475	4	8	4
5	L:L:F44	7.0325	4	8	8
6	L:L:F48	6.67	4	0	3
7	L:L:R53	4.816	5	2	4
8	L:L:P59	5.6975	4	0	7
9	L:L:E65	4.315	4	2	9
10	L:L:I67	4.26	4	2	9
11	L:L:D79	4.95	4	0	6
12	L:L:W84	7.404	5	0	3
13	L:L:F92	5.8125	4	9	6
14	L:L:L93	4.105	4	9	6
15	N:N:F44	4.648	5	3	8
16	N:N:I49	7.0125	4	0	9
17	N:N:E51	8.3675	4	2	5
18	N:N:R53	9.8525	4	7	4
19	N:N:E56	6.0125	4	0	4
20	N:N:L78	5.4925	4	3	9
21	N:N:D79	5.78	4	0	6
22	N:N:W84	8.968	5	3	3
23	N:N:F92	7.2175	4	10	6
24	R:R:P31	8.15	4	8	5
25	R:R:P38	4.615	4	0	7
26	R:R:Y55	5.8675	4	5	7
27	R:R:Y86	5.864	5	0	7
28	R:R:F97	4.83	4	0	6
29	R:R:K108	5.378	5	5	5
30	R:R:W112	6.17571	7	4	9
31	R:R:F114	5.82	4	4	6
32	R:R:Y131	7.365	4	0	7
33	R:R:Y145	7.358	5	15	8
34	R:R:H150	6.2475	4	15	6
35	R:R:R159	5.69	4	13	3
36	R:R:Y197	7.508	5	1	3
37	R:R:M200	6.71	4	0	5
38	R:R:R208	10.6625	4	1	4
39	R:R:R212	6.734	5	1	5
40	R:R:F220	7.285	4	0	8
41	R:R:P223	3.2125	4	0	9
42	R:R:L224	3.9	4	0	7
43	R:R:Y231	7.38667	6	6	9
44	R:R:M243	2.3575	4	0	4
45	R:R:V256	4.6375	4	6	8
46	R:R:W264	6.034	5	14	8
47	R:R:Y267	6.145	4	0	7
48	R:R:D274	9.42	4	1	4
49	R:R:M277	5.32	4	1	4
50	R:R:R278	8.15	4	1	4
51	R:R:E284	6.1075	4	1	3
52	R:R:R289	7.388	5	1	3
53	R:R:N310	5.17	4	0	9
54	R:R:Y314	7.728	5	6	9
55	R:R:F316	2.9225	4	0	6
56	R:R:F321	4.105	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E300	R:R:Y267	24.6706	7.86	No	Yes	0	5	7
2	R:R:L271	R:R:Y267	13.2966	8.21	No	Yes	0	6	7
3	R:R:L271	R:R:R212	38.6047	10.93	No	Yes	0	6	5
4	R:R:R208	R:R:R212	33.4535	3.2	Yes	Yes	1	4	5
5	R:R:R208	R:R:Y197	52.9405	18.52	Yes	Yes	1	4	3
6	R:R:V187	R:R:Y197	100	5.05	No	Yes	0	3	3
7	L:L:P59	R:R:V187	99.6479	5.3	Yes	No	0	7	3
8	L:L:G58	L:L:P59	97.6722	4.06	No	Yes	0	8	7
9	L:L:G58	L:L:H60	97.2381	3.18	No	No	0	8	8
10	L:L:H60	L:L:I55	88.8089	3.98	No	No	0	8	6
11	L:L:I55	L:L:R53	85.5925	5.01	No	Yes	2	6	4
12	R:R:L296	R:R:Y267	15.6142	3.52	No	Yes	0	5	7
13	L:L:E31	R:R:L296	18.1265	3.98	Yes	No	0	7	5
14	L:L:E31	R:R:R208	23.3341	11.63	Yes	Yes	1	7	4
15	R:R:E300	R:R:K108	20.3398	5.4	No	Yes	5	5	5
16	L:L:F44	L:L:I49	26.231	5.02	Yes	No	0	8	9
17	L:L:F92	L:L:I49	29.374	8.79	Yes	No	0	6	9
18	L:L:F92	L:L:L93	33.1339	3.65	Yes	Yes	9	6	6
19	L:L:L93	N:N:V54	39.2747	4.47	Yes	No	0	6	5
20	N:N:I66	N:N:V54	39.9634	3.07	No	No	0	9	5
21	N:N:I66	N:N:P80	40.6744	5.08	No	No	0	9	9
22	N:N:P80	N:N:T64	62.6156	3.5	No	No	0	9	6
23	N:N:S57	N:N:T64	63.2377	3.2	No	No	0	6	6
24	N:N:G58	N:N:S57	63.8564	1.86	No	No	0	8	6
25	N:N:G58	N:N:H60	65.0835	3.18	No	No	0	8	8
26	N:N:C61	N:N:H60	65.6919	7.37	No	No	0	9	8
27	N:N:C61	N:N:E65	66.1465	3.04	No	No	11	9	9
28	N:N:C36	N:N:E65	67.4967	6.08	No	No	0	9	9
29	N:N:C36	N:N:I67	68.6828	3.27	No	No	0	9	9
30	N:N:I67	N:N:R53	69.2707	3.76	No	Yes	0	9	4
31	L:L:E51	N:N:R53	70.274	15.12	No	Yes	7	5	4
32	L:L:E51	L:L:K69	72.3266	5.4	No	No	0	5	8
33	L:L:E75	L:L:K69	72.8957	12.15	No	No	0	4	8
34	L:L:E75	L:L:R53	76.9291	3.49	No	Yes	0	4	4
35	L:L:F44	L:L:W84	12.2849	7.02	Yes	Yes	0	8	3
36	N:N:F44	N:N:I49	10.1912	6.28	Yes	Yes	0	8	9
37	N:N:F44	N:N:W84	14.1204	6.01	Yes	Yes	3	8	3
38	N:N:E82	N:N:W84	19.0443	4.36	No	Yes	0	7	3
39	N:N:D79	N:N:E82	19.8578	5.2	Yes	No	0	6	7
40	N:N:D79	N:N:P80	23.0914	8.05	Yes	No	0	6	9
41	R:R:A37	R:R:P38	11.1364	1.87	No	Yes	0	7	7
42	R:R:E198	R:R:Y197	48.784	5.61	No	Yes	1	5	3
43	R:R:E198	R:R:R184	52.4739	12.79	No	No	1	5	5
44	R:R:R184	R:R:V180	51.8432	10.46	No	No	1	5	4
45	R:R:E127	R:R:V180	52.0825	9.98	No	No	0	4	4
46	R:R:E127	R:R:Y131	51.8911	8.98	No	Yes	0	4	7
47	R:R:F130	R:R:Y131	55.8117	9.28	No	Yes	0	7	7
48	R:R:F130	R:R:W264	53.3712	8.02	No	Yes	14	7	8
49	R:R:H306	R:R:W264	44.2276	6.35	No	Yes	0	9	8
50	R:R:F97	R:R:H306	26.3643	3.39	Yes	No	0	6	9
51	R:R:F97	R:R:K126	18.9605	6.2	Yes	No	0	6	6
52	R:R:K126	R:R:W104	18.2735	12.76	No	No	0	6	6
53	R:R:W104	R:R:W112	16.1166	3.75	No	Yes	4	6	9
54	R:R:K108	R:R:Y55	14.9784	7.17	Yes	Yes	5	5	7
55	R:R:I304	R:R:Y55	15.7372	7.25	No	Yes	0	7	7
56	R:R:I304	R:R:L101	12.7378	5.71	No	No	0	7	8
57	R:R:H306	R:R:N310	38.644	3.83	No	Yes	0	9	9
58	R:R:D94	R:R:N310	22.1292	8.08	No	Yes	0	9	9
59	R:R:D94	R:R:N66	21.4131	5.39	No	No	0	9	9
60	R:R:N66	R:R:P311	17.0447	6.52	No	No	0	9	9
61	R:R:F316	R:R:P311	14.064	2.89	Yes	No	0	6	9
62	R:R:F316	R:R:V69	11.0287	3.93	Yes	No	0	6	8
63	R:R:F260	R:R:W264	27.8768	6.01	No	Yes	0	9	8
64	R:R:F260	R:R:M227	42.3493	11.2	No	No	0	9	8
65	R:R:M227	R:R:Y231	31.0027	3.59	No	Yes	6	8	9
66	R:R:R144	R:R:Y231	18.711	8.23	No	Yes	0	9	9
67	R:R:I140	R:R:R144	22.4283	6.26	No	No	0	9	9
68	R:R:I140	R:R:Y86	21.1362	6.04	No	Yes	0	9	7
69	R:R:L271	R:R:Q216	26.5386	7.99	No	No	0	6	5
70	R:R:N268	R:R:Q216	26.3728	7.92	No	No	0	8	5
71	R:R:F220	R:R:N268	26.2549	16.92	Yes	No	0	8	8
72	R:R:F220	R:R:L224	27.911	3.65	Yes	Yes	0	8	7
73	R:R:F260	R:R:L224	27.5777	3.65	No	Yes	0	9	7
74	R:R:N310	R:R:Y314	20.979	4.65	Yes	Yes	0	9	9
75	R:R:R144	R:R:Y314	14.1768	6.17	No	Yes	0	9	9
76	R:R:M227	R:R:S141	10.7296	4.6	No	No	6	8	9
77	R:R:C230	R:R:S141	12.8369	5.16	No	No	0	7	9
78	R:R:C230	R:R:Y145	10.7313	6.72	No	Yes	0	7	8
79	R:R:I253	R:R:Y231	19.9604	9.67	No	Yes	0	7	9
80	R:R:I253	R:R:T234	13.8162	3.04	No	No	0	7	8
81	R:R:M209	R:R:T279	10.4886	4.52	No	No	0	3	1
82	R:R:L238	R:R:T234	11.3346	2.95	No	No	0	8	8
83	R:R:F97	R:R:L101	11.5414	7.31	Yes	No	0	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R27	R:R:S43	5.27	0	No	No	4	5	0	1
L:L:K30	R:R:K108	5.75	5	No	Yes	1	5	0	1
L:L:K30	R:R:D297	5.53	5	No	No	1	4	0	1
L:L:K30	R:R:E300	12.15	5	No	No	1	5	0	1
L:L:E31	R:R:R208	11.63	1	Yes	Yes	7	4	0	1
L:L:E31	R:R:R212	5.82	1	Yes	Yes	7	5	0	1
L:L:E31	R:R:D274	9.09	1	Yes	Yes	7	4	0	1
L:L:E31	R:R:R278	6.98	1	Yes	Yes	7	4	0	1
L:L:E31	R:R:L296	3.98	1	Yes	No	7	5	0	1
L:L:L32	R:R:S189	4.5	0	No	No	8	1	0	1
L:L:L32	R:R:Y197	7.03	0	No	Yes	8	3	0	1
L:L:R33	R:R:D274	11.91	1	Yes	Yes	8	4	0	1
L:L:R33	R:R:M277	3.72	1	Yes	Yes	8	4	0	1
L:L:R33	R:R:R278	7.46	1	Yes	Yes	8	4	0	1
L:L:R33	R:R:R289	12.79	1	Yes	Yes	8	3	0	1
L:L:R33	R:R:D293	8.34	1	Yes	No	8	4	0	1
L:L:Q35	R:R:N191	15.85	2	Yes	No	4	2	0	1
L:L:I37	R:R:E284	5.47	1	No	Yes	5	3	0	1
L:L:I37	R:R:R289	5.01	1	No	Yes	5	3	0	1
L:L:Y40	R:R:P31	4.17	8	Yes	Yes	4	5	0	1
L:L:F44	R:R:P31	13	8	Yes	Yes	8	5	0	1
L:L:K47	R:R:T28	4.5	0	No	No	7	7	0	1
L:L:F48	R:R:P30	4.33	0	Yes	No	3	3	0	1
L:L:F48	R:R:P31	7.22	0	Yes	Yes	3	5	0	1
L:L:S57	R:R:N202	7.45	0	No	No	6	2	0	1
L:L:P59	R:R:V187	5.3	0	Yes	No	7	3	0	1
L:L:P59	R:R:D199	6.44	0	Yes	No	7	4	0	1
L:L:P59	R:R:T204	6.99	0	Yes	No	7	3	0	1
L:L:I67	R:R:P38	3.39	2	Yes	Yes	9	7	0	1
L:L:L70	R:R:P31	8.21	0	No	Yes	7	5	0	1
L:L:R74	R:R:F32	8.55	0	No	No	2	3	0	1
L:L:R74	R:R:L33	9.72	0	No	No	2	3	0	1
L:L:E75	R:R:P38	9.43	0	No	Yes	4	7	0	1
L:L:C77	R:R:P38	3.77	0	No	Yes	9	7	0	1
N:N:E51	R:R:S190	8.62	2	Yes	No	5	2	0	1
N:N:K69	R:R:S190	6.12	2	No	No	8	2	0	1
N:N:G73	R:R:Y188	7.24	0	No	No	7	1	0	1
R:R:F32	R:R:L34	3.65	0	No	No	3	2	1	2
R:R:A37	R:R:L33	3.15	0	No	No	7	3	2	1
R:R:C39	R:R:R289	8.36	0	No	Yes	8	3	2	1
R:R:E40	R:R:P41	3.14	0	No	No	4	4	2	1
R:R:N191	R:R:P41	4.89	0	No	No	2	4	1	1
R:R:V51	R:R:Y55	5.05	5	No	Yes	5	7	2	2
R:R:K108	R:R:V51	3.04	5	Yes	No	5	5	1	2
R:R:I301	R:R:V51	3.07	0	No	No	5	5	2	2
R:R:K108	R:R:Y55	7.17	5	Yes	Yes	5	7	1	2
R:R:D297	R:R:K108	5.53	5	No	Yes	4	5	1	1
R:R:E300	R:R:K108	5.4	5	No	Yes	5	5	1	1
R:R:G111	R:R:S193	3.71	0	No	No	4	3	2	1
R:R:D199	R:R:R185	9.53	0	No	No	4	4	1	2
R:R:V187	R:R:Y197	5.05	0	No	Yes	3	3	1	1
R:R:P194	R:R:Y188	8.34	0	No	No	5	1	2	1
R:R:P194	R:R:S193	3.56	0	No	No	5	3	2	1
R:R:E198	R:R:Y197	5.61	1	No	Yes	5	3	2	1
R:R:R208	R:R:Y197	18.52	1	Yes	Yes	4	3	1	1
R:R:E198	R:R:R208	9.3	1	No	Yes	5	4	2	1
R:R:M200	R:R:T204	3.01	0	Yes	No	5	3	2	1
R:R:R208	R:R:R212	3.2	1	Yes	Yes	4	5	1	1
R:R:M209	R:R:T275	3.01	0	No	No	3	4	2	2
R:R:M209	R:R:R278	7.44	0	No	Yes	3	4	2	1
R:R:L271	R:R:R212	10.93	0	No	Yes	6	5	2	1
R:R:D274	R:R:R212	5.96	1	Yes	Yes	4	5	1	1
R:R:R212	R:R:T275	7.76	1	Yes	No	5	4	1	2
R:R:L271	R:R:Y267	8.21	0	No	Yes	6	7	2	2
R:R:L296	R:R:Y267	3.52	0	No	Yes	5	7	1	2
R:R:E300	R:R:Y267	7.86	5	No	Yes	5	7	1	2
R:R:L296	R:R:V270	4.47	0	No	No	5	4	1	2
R:R:D274	R:R:R278	10.72	1	Yes	Yes	4	4	1	1
R:R:E284	R:R:M277	6.77	1	Yes	Yes	3	4	1	1
R:R:M277	R:R:R289	4.96	1	Yes	Yes	4	3	1	1
R:R:I292	R:R:M277	5.83	0	No	Yes	5	4	2	1
R:R:E284	R:R:Q280	6.37	1	Yes	No	3	2	1	2
R:R:E284	R:R:R289	5.82	1	Yes	Yes	3	3	1	1
R:R:D297	R:R:I301	4.2	5	No	No	4	5	1	2
L:L:L32	R:R:V192	2.98	0	No	No	8	5	0	1
L:L:R27	R:R:P41	2.88	0	No	No	4	4	0	1
R:R:A37	R:R:P38	1.87	0	No	Yes	7	7	2	1
R:R:G201	R:R:T204	1.82	0	No	No	4	3	2	1
R:R:L29	R:R:P30	1.64	0	No	No	3	3	2	1
L:L:S28	R:R:S193	1.63	0	No	No	1	3	0	1
L:L:L76	R:R:A36	1.58	0	No	No	4	5	0	1
R:R:A36	R:R:D35	1.54	0	No	No	5	6	1	2
R:R:A195	R:R:Y197	1.33	0	No	Yes	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XX6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	413
Number of Links	456
Number of Hubs	56
Number of Links mediated by Hubs	204
Number of Communities	15
Number of Nodes involved in Communities	79
Number of Links involved in Communities	100

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	111736
Length Of Smallest Path	3
Average Path Length	21.9646
Length of Longest Path	54
Minimum Path Strength	1.38
Average Path Strength	6.18399
Maximum Path Strength	16.175
Minimum Path Correlation	0.7
Average Path Correlation	0.955805
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.27273
Average % Of Corr. Nodes	53.3845
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.7782
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	CXCL8
UniProt	P10145
Sequence	>8XX6_nogp_Chain_L P R S A K E L R C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	N
Protein	CXCL8
UniProt	P10145
Sequence	>8XX6_nogp_Chain_N C Q C I K T Y S K P F H P K F I K E L R V I E S G P H C A N T E I I V K L S D G R E L C L D P K E N W V Q R V V E K F L K R A E N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XX6_nogp_Chain_R T L P P F L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XX6_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.