psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C286	R:R:C39	7.28	No	No	0	6	8
2	R:R:C39	R:R:R289	4.18	No	No	0	8	3
3	R:R:E40	R:R:P41	3.14	No	No	0	4	4
4	R:R:E45	R:R:K48	6.75	No	No	0	4	4
5	R:R:F50	R:R:I54	11.3	No	No	0	5	5
6	R:R:K108	R:R:V51	4.55	Yes	Yes	1	5	5
7	R:R:D297	R:R:V51	7.3	No	Yes	1	4	5
8	R:R:I301	R:R:V51	6.14	No	Yes	0	5	5
9	R:R:L101	R:R:Y55	3.52	Yes	Yes	1	8	7
10	R:R:W104	R:R:Y55	4.82	Yes	Yes	1	6	7
11	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
12	R:R:E300	R:R:Y55	5.61	Yes	Yes	1	5	7
13	R:R:I301	R:R:Y55	3.63	No	Yes	0	5	7
14	R:R:I304	R:R:Y55	3.63	Yes	Yes	1	7	7
15	R:R:C308	R:R:V58	5.12	No	No	0	7	7
16	R:R:F59	R:R:P102	11.56	No	No	0	7	9
17	R:R:C308	R:R:L61	3.17	No	No	0	7	5
18	R:R:S307	R:R:S62	6.52	No	No	0	8	8
19	R:R:C308	R:R:S62	5.16	No	No	0	7	8
20	R:R:G65	R:R:L68	3.42	No	No	0	7	6
21	R:R:G65	R:R:P311	4.06	No	Yes	0	7	9
22	R:R:A91	R:R:N66	3.13	No	Yes	0	8	9
23	R:R:D94	R:R:N66	6.73	Yes	Yes	0	9	9
24	R:R:N66	R:R:P311	4.89	Yes	Yes	0	9	9
25	R:R:F316	R:R:L68	4.87	No	No	0	6	6
26	R:R:A91	R:R:V69	3.39	No	No	0	8	8
27	R:R:P311	R:R:V69	3.53	Yes	No	0	9	8
28	R:R:A315	R:R:V69	3.39	No	No	0	7	8
29	R:R:L88	R:R:M70	4.24	No	No	0	5	6
30	R:R:A91	R:R:M70	3.22	No	No	0	8	6
31	R:R:L92	R:R:M70	4.24	No	No	0	6	6
32	R:R:L71	R:R:Y75	3.52	No	No	0	3	4
33	R:R:F321	R:R:V72	6.55	Yes	No	0	8	7
34	R:R:L325	R:R:V72	4.47	No	No	0	6	7
35	R:R:I73	R:R:R80	3.76	No	No	0	6	7
36	R:R:I73	R:R:L88	8.56	No	No	0	6	5
37	R:R:F321	R:R:I73	5.02	Yes	No	0	8	6
38	R:R:I328	R:R:Y75	14.51	No	No	0	5	4
39	R:R:R77	R:R:R80	5.33	No	No	0	6	7
40	R:R:D143	R:R:V82	4.38	No	Yes	1	8	7
41	R:R:R159	R:R:V82	3.92	No	Yes	1	3	7
42	R:R:V162	R:R:V82	4.81	No	Yes	0	7	7
43	R:R:V162	R:R:V85	8.02	No	No	0	7	6
44	R:R:C139	R:R:Y86	5.38	No	Yes	1	5	7
45	R:R:I140	R:R:Y86	4.84	No	Yes	1	9	7
46	R:R:D143	R:R:Y86	4.6	No	Yes	1	8	7
47	R:R:V162	R:R:Y86	6.31	No	Yes	0	7	7
48	R:R:I165	R:R:Y86	4.84	No	Yes	1	5	7
49	R:R:A315	R:R:L87	3.15	No	No	3	7	7
50	R:R:F321	R:R:L87	3.65	Yes	No	3	8	7
51	R:R:C166	R:R:N89	9.45	No	No	0	7	9
52	R:R:N89	R:R:W170	4.52	No	Yes	0	9	9
53	R:R:L136	R:R:L90	4.15	No	Yes	0	8	9
54	R:R:L137	R:R:L90	5.54	No	Yes	1	8	9
55	R:R:L90	R:R:N310	8.24	Yes	No	1	9	9
56	R:R:L90	R:R:Y314	3.52	Yes	Yes	1	9	9
57	R:R:L92	R:R:L96	4.15	No	No	0	6	7
58	R:R:D94	R:R:H306	6.3	Yes	Yes	1	9	9
59	R:R:D94	R:R:S307	5.89	Yes	No	1	9	8
60	R:R:D94	R:R:N310	10.77	Yes	No	1	9	9
61	R:R:L96	R:R:N129	8.24	No	No	0	7	8
62	R:R:F97	R:R:L101	8.53	Yes	Yes	1	6	8
63	R:R:F97	R:R:K126	9.93	Yes	No	0	6	6
64	R:R:F97	R:R:N129	4.83	Yes	No	0	6	8
65	R:R:F97	R:R:I304	3.77	Yes	Yes	1	6	7
66	R:R:F97	R:R:H306	3.39	Yes	Yes	1	6	9
67	R:R:L125	R:R:T100	4.42	No	No	0	4	7
68	R:R:K126	R:R:T100	4.5	No	No	0	6	7
69	R:R:I304	R:R:L101	5.71	Yes	Yes	1	7	8
70	R:R:I103	R:R:W112	3.52	No	Yes	1	6	9
71	R:R:I103	R:R:V122	6.14	No	No	1	6	5
72	R:R:K108	R:R:W104	3.48	Yes	Yes	1	5	6
73	R:R:W104	R:R:W112	3.75	Yes	Yes	1	6	9
74	R:R:K126	R:R:W104	10.44	No	Yes	0	6	6
75	R:R:E300	R:R:W104	3.27	Yes	Yes	1	5	6
76	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
77	R:R:D297	R:R:K108	9.68	No	Yes	1	4	5
78	R:R:E300	R:R:K108	8.1	Yes	Yes	1	5	5
79	R:R:I113	R:R:N110	4.25	No	No	0	3	4
80	R:R:C119	R:R:W112	7.84	No	Yes	1	9	9
81	R:R:V122	R:R:W112	6.13	No	Yes	1	5	9
82	R:R:C196	R:R:W112	10.45	No	Yes	1	9	9
83	R:R:F114	R:R:I113	3.77	Yes	No	0	6	3
84	R:R:F114	R:R:L118	4.87	Yes	No	0	6	6
85	R:R:T116	R:R:T186	6.28	No	No	0	3	4
86	R:R:F117	R:R:V121	5.24	No	No	0	1	5
87	R:R:C119	R:R:C196	7.28	No	No	1	9	9
88	R:R:C196	R:R:S123	5.16	No	No	0	9	5
89	R:R:L124	R:R:L181	9.69	No	Yes	0	6	5
90	R:R:E127	R:R:Y131	5.61	Yes	Yes	4	4	7
91	R:R:E127	R:R:V180	5.7	Yes	No	0	4	4
92	R:R:E127	R:R:P215	3.14	Yes	No	4	4	5
93	R:R:S173	R:R:V128	4.85	No	No	0	7	5
94	R:R:L174	R:R:V128	8.94	No	No	0	5	5
95	R:R:F130	R:R:I134	6.28	No	Yes	1	7	8
96	R:R:F130	R:R:W264	10.02	No	Yes	1	7	8
97	R:R:S173	R:R:Y131	5.09	No	Yes	0	7	7
98	R:R:L176	R:R:Y131	7.03	No	Yes	0	4	7
99	R:R:P215	R:R:Y131	6.95	No	Yes	4	5	7
100	R:R:S132	R:R:W170	9.88	No	Yes	0	6	9
101	R:R:S132	R:R:S173	6.52	No	No	0	6	7
102	R:R:I134	R:R:P223	3.39	Yes	No	0	8	9
103	R:R:F260	R:R:I134	3.77	Yes	Yes	1	9	8
104	R:R:I134	R:R:W264	5.87	Yes	Yes	1	8	8
105	R:R:I169	R:R:L135	8.56	No	No	0	6	6
106	R:R:L137	R:R:Y314	8.21	No	Yes	1	8	9
107	R:R:A138	R:R:I226	3.25	No	No	0	7	6
108	R:R:C139	R:R:I165	3.27	No	No	1	5	5
109	R:R:C139	R:R:I169	3.27	No	No	0	5	6
110	R:R:I140	R:R:R144	6.26	No	No	1	9	9
111	R:R:I140	R:R:Y314	4.84	No	Yes	1	9	9
112	R:R:M227	R:R:S141	6.13	No	No	0	8	9
113	R:R:S141	R:R:Y231	5.09	No	Yes	0	9	9
114	R:R:C230	R:R:V142	3.42	No	No	0	7	6
115	R:R:D143	R:R:R159	9.53	No	No	1	8	3
116	R:R:R144	R:R:Y231	8.23	No	Yes	0	9	9
117	R:R:R144	R:R:Y314	6.17	No	Yes	1	9	9
118	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
119	R:R:V149	R:R:Y145	7.57	No	Yes	0	7	8
120	R:R:H150	R:R:Y145	6.53	No	Yes	0	6	8
121	R:R:F229	R:R:Y145	7.22	No	Yes	5	4	8
122	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
123	R:R:F233	R:R:Y145	7.22	No	Yes	5	4	8
124	R:R:A147	R:R:R159	5.53	No	No	0	8	3
125	R:R:I148	R:R:T234	6.08	No	Yes	0	8	8
126	R:R:T234	R:R:V149	3.17	Yes	No	0	8	7
127	R:R:T237	R:R:V149	6.35	No	No	0	5	7
128	R:R:H150	R:R:R153	3.39	No	No	0	6	5
129	R:R:H150	R:R:L155	11.57	No	No	0	6	4
130	R:R:Q157	R:R:Y160	9.02	No	No	0	7	5
131	R:R:K163	R:R:L167	9.87	No	No	0	4	3
132	R:R:L172	R:R:L176	5.54	No	No	0	4	4
133	R:R:F218	R:R:L176	4.87	No	No	0	4	4
134	R:R:F183	R:R:P179	4.33	No	No	0	5	8
135	R:R:L211	R:R:P179	3.28	No	No	0	4	8
136	R:R:R184	R:R:V180	10.46	No	No	0	5	4
137	R:R:F183	R:R:L182	10.96	No	No	0	5	4
138	R:R:E198	R:R:R184	9.3	No	No	0	5	5
139	R:R:D199	R:R:R185	21.44	No	No	0	4	4
140	R:R:V187	R:R:Y197	5.05	No	No	0	3	3
141	R:R:P194	R:R:Y188	5.56	No	No	0	5	1
142	R:R:S189	R:R:V192	4.85	No	No	0	1	5
143	R:R:N191	R:R:V192	4.43	No	No	0	2	5
144	R:R:P194	R:R:S193	3.56	No	No	0	5	3
145	R:R:R208	R:R:Y197	19.55	No	No	0	4	3
146	R:R:E198	R:R:M200	4.06	No	No	0	5	5
147	R:R:E198	R:R:R208	26.75	No	No	0	5	4
148	R:R:M200	R:R:T204	7.53	No	No	0	5	3
149	R:R:M200	R:R:W207	5.82	No	No	0	5	3
150	R:R:N203	R:R:N206	4.09	No	No	0	4	1
151	R:R:R208	R:R:R212	4.26	No	Yes	0	4	5
152	R:R:M209	R:R:R212	6.2	No	Yes	2	3	5
153	R:R:M209	R:R:T275	7.53	No	No	2	3	4
154	R:R:M209	R:R:R278	6.2	No	No	0	3	4
155	R:R:Q216	R:R:R212	4.67	No	Yes	2	5	5
156	R:R:L271	R:R:R212	9.72	Yes	Yes	2	6	5
157	R:R:D274	R:R:R212	3.57	No	Yes	0	4	5
158	R:R:R212	R:R:T275	7.76	Yes	No	2	5	4
159	R:R:I213	R:R:L214	4.28	No	No	0	4	3
160	R:R:N268	R:R:Q216	10.56	No	No	0	8	5
161	R:R:L271	R:R:Q216	5.32	Yes	No	2	6	5
162	R:R:F218	R:R:S217	6.61	No	No	0	4	4
163	R:R:F220	R:R:F260	4.29	Yes	Yes	1	8	9
164	R:R:F220	R:R:L265	3.65	Yes	No	0	8	6
165	R:R:F220	R:R:N268	15.71	Yes	No	0	8	8
166	R:R:P223	R:R:V222	3.53	No	No	0	9	5
167	R:R:I226	R:R:V222	3.07	No	No	0	6	5
168	R:R:F260	R:R:M227	7.46	Yes	No	0	9	8
169	R:R:F229	R:R:F233	15	No	No	5	4	4
170	R:R:I253	R:R:Y231	12.09	No	Yes	0	7	9
171	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
172	R:R:I253	R:R:L235	4.28	No	Yes	0	7	4
173	R:R:F254	R:R:L235	3.65	No	Yes	0	4	4
174	R:R:K240	R:R:R236	4.95	No	No	0	5	4
175	R:R:A249	R:R:L238	3.15	No	No	0	7	8
176	R:R:A241	R:R:M243	3.22	No	No	0	3	4
177	R:R:G244	R:R:Q245	4.93	No	No	0	4	4
178	R:R:H247	R:R:K246	9.17	No	No	0	5	7
179	R:R:K246	R:R:M250	7.2	No	No	0	7	5
180	R:R:R248	R:R:R251	6.4	No	No	0	7	5
181	R:R:I317	R:R:V252	7.68	No	No	0	6	7
182	R:R:I313	R:R:V256	3.07	Yes	No	0	7	8
183	R:R:I259	R:R:L309	4.28	No	No	1	6	6
184	R:R:I259	R:R:I313	5.89	No	Yes	1	6	7
185	R:R:W264	R:R:Y267	6.75	Yes	No	0	8	7
186	R:R:H306	R:R:W264	7.41	Yes	Yes	1	9	8
187	R:R:L265	R:R:P266	3.28	No	No	0	6	9
188	R:R:L265	R:R:L269	4.15	No	No	0	6	6
189	R:R:P266	R:R:T299	3.5	No	No	0	9	6
190	R:R:L271	R:R:Y267	11.72	Yes	No	0	6	7
191	R:R:T299	R:R:Y267	3.75	No	No	0	6	7
192	R:R:T299	R:R:V270	7.93	No	No	0	6	4
193	R:R:L271	R:R:L296	4.15	Yes	No	0	6	5
194	R:R:D274	R:R:R278	4.76	No	No	0	4	4
195	R:R:L276	R:R:V281	4.47	No	No	0	4	4
196	R:R:E284	R:R:M277	10.83	No	No	0	3	4
197	R:R:I292	R:R:M277	4.37	No	No	0	5	4
198	R:R:T279	R:R:V281	3.17	No	No	0	1	4
199	R:R:I282	R:R:R288	3.76	No	No	0	5	1
200	R:R:E284	R:R:R289	10.47	No	No	0	3	3
201	R:R:E300	R:R:I304	4.1	Yes	Yes	1	5	7
202	R:R:H306	R:R:S307	4.18	Yes	No	1	9	8
203	R:R:I313	R:R:L309	5.71	Yes	No	1	7	6
204	R:R:N310	R:R:Y314	4.65	No	Yes	1	9	9
205	R:R:I313	R:R:Y314	4.84	Yes	Yes	1	7	9
206	R:R:A315	R:R:F321	5.55	No	Yes	3	7	8
207	R:R:Q319	R:R:R322	12.85	No	No	0	5	8
208	R:R:H323	R:R:K327	5.24	No	No	0	4	4
209	R:R:I253	R:R:T234	3.04	No	Yes	0	7	8
210	R:R:A177	R:R:E127	3.02	No	Yes	0	7	4
211	R:R:F114	R:R:W112	3.01	Yes	Yes	0	6	9
212	R:R:L63	R:R:S67	3	No	No	0	5	3
213	R:R:K120	R:R:T116	3	No	No	0	7	3
214	R:R:L124	R:R:V128	2.98	No	No	0	6	5
215	R:R:N47	R:R:V51	2.96	No	Yes	0	4	5
216	R:R:I301	R:R:I54	2.94	No	No	0	5	5
217	R:R:I53	R:R:L57	2.85	No	No	0	5	5
218	R:R:I165	R:R:L161	2.85	No	No	0	5	4
219	R:R:Q157	R:R:T156	2.83	No	No	0	7	2
220	R:R:L235	R:R:M250	2.83	Yes	No	0	4	5
221	R:R:K158	R:R:L155	2.82	No	No	0	6	4
222	R:R:D274	R:R:I292	2.8	No	No	0	4	5
223	R:R:L64	R:R:L68	2.77	No	No	0	4	6
224	R:R:L74	R:R:L88	2.77	No	No	0	2	5
225	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
226	R:R:L224	R:R:L261	2.77	No	No	0	7	6
227	R:R:L95	R:R:N66	2.75	No	Yes	0	7	9
228	R:R:K158	R:R:Q157	2.71	No	No	0	6	7
229	R:R:A93	R:R:W170	2.59	No	Yes	0	8	9
230	R:R:R185	R:R:T116	2.59	No	No	0	4	3
231	R:R:F164	R:R:K163	2.48	No	No	0	3	4
232	R:R:M277	R:R:R288	2.48	No	No	0	4	1
233	R:R:F220	R:R:L224	2.44	Yes	No	1	8	7
234	R:R:F260	R:R:L224	2.44	Yes	No	1	9	7
235	R:R:D84	R:R:F321	2.39	No	Yes	0	8	8
236	R:R:L210	R:R:W207	2.28	No	No	0	2	3
237	R:R:G219	R:R:P223	2.03	No	No	0	5	9
238	R:R:G111	R:R:S107	1.86	No	No	0	4	5
239	R:R:G133	R:R:S132	1.86	No	No	0	9	6
240	R:R:G115	R:R:T186	1.82	No	No	0	8	4
241	R:R:G201	R:R:T204	1.82	No	No	0	4	3
242	R:R:G318	R:R:I317	1.76	No	No	0	7	6
243	R:R:G244	R:R:M243	1.75	No	No	0	4	4
244	R:R:G324	R:R:K327	1.74	No	No	0	5	4
245	R:R:A98	R:R:S62	1.71	No	No	0	5	8
246	R:R:G232	R:R:L235	1.71	No	Yes	0	3	4
247	R:R:G303	R:R:L302	1.71	No	No	0	7	7
248	R:R:A295	R:R:V270	1.7	No	No	0	5	4
249	R:R:L101	R:R:P102	1.64	Yes	No	0	8	9
250	R:R:L178	R:R:P179	1.64	No	No	0	3	8
251	R:R:L214	R:R:P215	1.64	No	No	0	3	5
252	R:R:C263	R:R:I259	1.64	No	No	0	7	6
253	R:R:L302	R:R:P266	1.64	No	No	0	7	9
254	R:R:L312	R:R:P311	1.64	No	Yes	0	6	9
255	R:R:A273	R:R:I292	1.62	No	No	0	5	5
256	R:R:V109	R:R:V52	1.6	No	No	0	4	5
257	R:R:V252	R:R:V256	1.6	No	No	0	7	8
258	R:R:T83	R:R:V82	1.59	No	Yes	0	7	7
259	R:R:C263	R:R:L262	1.59	No	No	0	7	5
260	R:R:T275	R:R:T279	1.57	No	No	0	4	1
261	R:R:I221	R:R:S217	1.55	No	No	0	4	4
262	R:R:I53	R:R:V52	1.54	No	No	0	5	5
263	R:R:G318	R:R:R322	1.5	No	No	0	7	8
264	R:R:L305	R:R:V58	1.49	No	No	0	5	7
265	R:R:N110	R:R:V109	1.48	No	No	0	4	4
266	R:R:L238	R:R:T234	1.47	No	Yes	0	8	8
267	R:R:K246	R:R:M243	1.44	No	No	0	7	4
268	R:R:I221	R:R:L225	1.43	No	No	0	4	3
269	R:R:K120	R:R:L181	1.41	No	Yes	0	7	5
270	R:R:G171	R:R:W170	1.41	No	Yes	0	4	9
271	R:R:E287	R:R:T285	1.41	No	No	0	4	5
272	R:R:L63	R:R:L95	1.38	No	No	0	5	7
273	R:R:L172	R:R:L175	1.38	No	No	0	4	4
274	R:R:L175	R:R:L178	1.38	No	No	0	4	3
275	R:R:L178	R:R:L181	1.38	No	Yes	0	3	5
276	R:R:L181	R:R:L182	1.38	Yes	No	0	5	4
277	R:R:L211	R:R:L214	1.38	No	No	0	4	3
278	R:R:E42	R:R:N290	1.31	No	No	0	4	3
279	R:R:R248	R:R:V252	1.31	No	No	0	7	7
280	R:R:R236	R:R:T237	1.29	No	No	0	4	5
281	R:R:R288	R:R:T285	1.29	No	No	0	1	5
282	R:R:V52	R:R:Y49	1.26	No	No	0	5	2
283	R:R:T186	R:R:Y188	1.25	No	No	0	4	1
284	R:R:E287	R:R:H291	1.23	No	No	0	4	3
285	R:R:F164	R:R:L161	1.22	No	No	0	3	4
286	R:R:K48	R:R:Y49	1.19	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V51	5.2375	4	1	5
2	R:R:Y55	4.20167	6	1	7
3	R:R:N66	4.375	4	0	9
4	R:R:V82	3.675	4	1	7
5	R:R:Y86	5.194	5	1	7
6	R:R:L90	5.3625	4	1	9
7	R:R:D94	7.4225	4	1	9
8	R:R:F97	6.09	5	1	6
9	R:R:L101	4.85	4	1	8
10	R:R:W104	5.152	5	1	6
11	R:R:K108	6.4525	4	1	5
12	R:R:W112	6.01571	7	1	9
13	R:R:F114	3.605	4	0	6
14	R:R:E127	4.3675	4	4	4
15	R:R:Y131	6.17	4	4	7
16	R:R:I134	4.8275	4	1	8
17	R:R:Y145	6.46333	6	5	8
18	R:R:W170	4.6	4	0	9
19	R:R:L181	3.465	4	0	5
20	R:R:R212	6.03	6	2	5
21	R:R:F220	6.5225	4	1	8
22	R:R:Y231	7.615	4	0	9
23	R:R:T234	3.44	4	0	8
24	R:R:L235	3.1175	4	0	4
25	R:R:F260	4.49	4	1	9
26	R:R:W264	7.5125	4	1	8
27	R:R:L271	7.7275	4	2	6
28	R:R:E300	5.27	4	1	5
29	R:R:I304	4.3025	4	1	7
30	R:R:H306	5.32	4	1	9
31	R:R:P311	3.53	4	0	9
32	R:R:I313	4.8775	4	1	7
33	R:R:Y314	5.37167	6	1	9
34	R:R:F321	4.632	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I292	R:R:M277	19.5008	4.37	No	No	0	5	4
2	R:R:D274	R:R:I292	23.0375	2.8	No	No	0	4	5
3	R:R:D274	R:R:R212	26.5138	3.57	No	Yes	0	4	5
4	R:R:L271	R:R:R212	82.6333	9.72	Yes	Yes	2	6	5
5	R:R:L271	R:R:Y267	86.2982	11.72	Yes	No	0	6	7
6	R:R:W264	R:R:Y267	92.3234	6.75	Yes	No	0	8	7
7	R:R:H306	R:R:W264	100	7.41	Yes	Yes	1	9	8
8	R:R:F97	R:R:H306	85.2575	3.39	Yes	Yes	1	6	9
9	R:R:F97	R:R:K126	46.8064	9.93	Yes	No	0	6	6
10	R:R:K126	R:R:W104	42.312	10.44	No	Yes	0	6	6
11	R:R:W104	R:R:W112	36.4377	3.75	Yes	Yes	1	6	9
12	R:R:F114	R:R:W112	22.7057	3.01	Yes	Yes	0	6	9
13	R:R:F114	R:R:I113	17.231	3.77	Yes	No	0	6	3
14	R:R:I113	R:R:N110	15.3759	4.25	No	No	0	3	4
15	R:R:N110	R:R:V109	13.5058	1.48	No	No	0	4	4
16	R:R:V109	R:R:V52	11.6205	1.6	No	No	0	4	5
17	R:R:F97	R:R:L101	16.952	8.53	Yes	Yes	1	6	8
18	R:R:L101	R:R:Y55	12.5858	3.52	Yes	Yes	1	8	7
19	R:R:I301	R:R:Y55	17.7136	3.63	No	Yes	0	5	7
20	R:R:F97	R:R:I304	21.6726	3.77	Yes	Yes	1	6	7
21	R:R:I304	R:R:Y55	12.0278	3.63	Yes	Yes	1	7	7
22	R:R:S307	R:R:S62	12.073	6.52	No	No	0	8	8
23	R:R:D94	R:R:H306	91.3883	6.3	Yes	Yes	1	9	9
24	R:R:D94	R:R:N66	53.3972	6.73	Yes	Yes	0	9	9
25	R:R:N66	R:R:P311	23.7237	4.89	Yes	Yes	0	9	9
26	R:R:A91	R:R:N66	23.9047	3.13	No	Yes	0	8	9
27	R:R:A91	R:R:V69	13.0156	3.39	No	No	0	8	8
28	R:R:P311	R:R:V69	13.3022	3.53	Yes	No	0	9	8
29	R:R:A315	R:R:V69	22.1175	3.39	No	No	0	7	8
30	R:R:L88	R:R:M70	11.1379	4.24	No	No	0	5	6
31	R:R:A315	R:R:F321	14.7349	5.55	No	Yes	3	7	8
32	R:R:D94	R:R:N310	78.6819	10.77	Yes	No	1	9	9
33	R:R:N310	R:R:Y314	73.3806	4.65	No	Yes	1	9	9
34	R:R:I140	R:R:Y314	28.6932	4.84	No	Yes	1	9	9
35	R:R:I140	R:R:Y86	34.5675	4.84	No	Yes	1	9	7
36	R:R:S132	R:R:S173	13.7697	6.52	No	No	0	6	7
37	R:R:S173	R:R:Y131	39.3258	5.09	No	Yes	0	7	7
38	R:R:E127	R:R:Y131	53.7591	5.61	Yes	Yes	4	4	7
39	R:R:E127	R:R:V180	70.4396	5.7	Yes	No	0	4	4
40	R:R:R184	R:R:V180	71.8498	10.46	No	No	0	5	4
41	R:R:E198	R:R:R184	73.2373	9.3	No	No	0	5	5
42	R:R:E198	R:R:R208	81.0422	26.75	No	No	0	5	4
43	R:R:R208	R:R:R212	84.6618	4.26	No	Yes	0	4	5
44	R:R:S173	R:R:V128	25.6919	4.85	No	No	0	7	5
45	R:R:L124	R:R:V128	22.1929	2.98	No	No	0	6	5
46	R:R:L124	R:R:L181	20.4585	9.69	No	Yes	0	6	5
47	R:R:K120	R:R:L181	17.5703	1.41	No	Yes	0	7	5
48	R:R:K120	R:R:T116	15.6776	3	No	No	0	7	3
49	R:R:E127	R:R:P215	13.8602	3.14	Yes	No	4	4	5
50	R:R:I134	R:R:W264	18.1962	5.87	Yes	Yes	1	8	8
51	R:R:L176	R:R:Y131	14.6595	7.03	No	Yes	0	4	7
52	R:R:I134	R:R:P223	10.776	3.39	Yes	No	0	8	9
53	R:R:Q216	R:R:R212	24.5381	4.67	No	Yes	2	5	5
54	R:R:N268	R:R:Q216	25.9332	10.56	No	No	0	8	5
55	R:R:F220	R:R:N268	26.0237	15.71	Yes	No	0	8	8
56	R:R:F220	R:R:F260	29.3869	4.29	Yes	Yes	1	8	9
57	R:R:F260	R:R:M227	32.8256	7.46	Yes	No	0	9	8
58	R:R:M227	R:R:S141	31.9358	6.13	No	No	0	8	9
59	R:R:S141	R:R:Y231	31.521	5.09	No	Yes	0	9	9
60	R:R:R144	R:R:Y231	38.3606	8.23	No	Yes	0	9	9
61	R:R:R144	R:R:Y314	31.3626	6.17	No	Yes	1	9	9
62	R:R:V149	R:R:Y145	25.1942	7.57	No	Yes	0	7	8
63	R:R:T234	R:R:V149	32.4938	3.17	Yes	No	0	8	7
64	R:R:I253	R:R:T234	39.4691	3.04	No	Yes	0	7	8
65	R:R:I253	R:R:Y231	57.4466	12.09	No	Yes	0	7	9
66	R:R:H150	R:R:Y145	13.7923	6.53	No	Yes	0	6	8
67	R:R:L214	R:R:P215	12.7215	1.64	No	No	0	3	5
68	R:R:I253	R:R:L235	19.727	4.28	No	Yes	0	7	4
69	R:R:K246	R:R:M250	12.0278	7.2	No	No	0	7	5
70	R:R:L235	R:R:M250	13.9808	2.83	Yes	No	0	4	5
71	R:R:I313	R:R:Y314	24.6135	4.84	Yes	Yes	1	7	9
72	R:R:I313	R:R:V256	15.4212	3.07	Yes	No	0	7	8
73	R:R:V252	R:R:V256	13.7094	1.6	No	No	0	7	8
74	R:R:T299	R:R:Y267	12.2841	3.75	No	No	0	6	7
75	R:R:F260	R:R:I134	11.7412	3.77	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8XXR_nogp

PDB Summary
PDB	8XXR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	259
Number of Links	286
Number of Hubs	34
Number of Links mediated by Hubs	125
Number of Communities	5
Number of Nodes involved in Communities	52
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	35337
Length Of Smallest Path	3
Average Path Length	13.3119
Length of Longest Path	33
Minimum Path Strength	1.225
Average Path Strength	6.30439
Maximum Path Strength	18.5333
Minimum Path Correlation	0.7
Average Path Correlation	0.930146
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	50.1675
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.4326
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XXR_nogp_Chain_R P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XXR_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.