psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A1	L:L:P2	3.74	No	No	0	0	0
2	L:L:P2	R:R:S43	3.56	No	No	0	0	5
3	L:L:L3	R:R:K48	9.87	No	No	0	0	4
4	L:L:L3	R:R:S193	4.5	No	No	0	0	3
5	L:L:E6	L:L:R8	4.65	Yes	Yes	1	0	0
6	L:L:E6	R:R:R208	11.63	Yes	No	1	0	4
7	L:L:E6	R:R:R212	3.49	Yes	Yes	1	0	5
8	L:L:E6	R:R:D274	6.5	Yes	Yes	1	0	4
9	L:L:E6	R:R:R278	6.98	Yes	Yes	1	0	4
10	L:L:E6	R:R:L296	3.98	Yes	No	0	0	5
11	L:L:H34	L:L:L7	5.14	Yes	No	0	0	0
12	L:L:L7	R:R:Y197	15.24	No	No	0	0	3
13	L:L:R8	R:R:D274	10.72	Yes	Yes	1	0	4
14	L:L:R8	R:R:R278	9.6	Yes	Yes	1	0	4
15	L:L:R8	R:R:R289	7.46	Yes	Yes	1	0	3
16	L:L:R8	R:R:D293	7.15	Yes	No	0	0	4
17	L:L:C35	L:L:C9	7.28	No	No	0	0	0
18	L:L:K27	L:L:Q10	4.07	Yes	Yes	0	0	0
19	L:L:E39	L:L:Q10	3.82	No	Yes	0	0	0
20	L:L:I41	L:L:Q10	6.86	No	Yes	0	0	0
21	L:L:Q10	R:R:N191	9.24	Yes	Yes	0	0	2
22	L:L:C11	L:L:I41	3.27	No	No	0	0	0
23	L:L:C11	L:L:C51	7.28	No	No	0	0	0
24	L:L:L12	R:R:C39	3.17	No	No	1	0	8
25	L:L:L12	R:R:E284	6.63	No	Yes	1	0	3
26	L:L:L12	R:R:R289	6.07	No	Yes	1	0	3
27	L:L:Q13	R:R:D35	7.83	No	No	0	0	6
28	L:L:N53	L:L:T14	4.39	Yes	No	0	0	0
29	L:L:L15	R:R:A36	4.73	No	No	0	0	5
30	L:L:Q16	L:L:S56	7.22	No	No	0	0	0
31	L:L:A50	L:L:I18	3.25	No	Yes	0	0	0
32	L:L:H19	L:L:N22	5.1	No	No	0	0	0
33	L:L:I23	L:L:L20	4.28	Yes	No	0	0	0
34	L:L:S25	L:L:T43	4.8	No	No	0	0	0
35	L:L:S25	N:N:K27	3.06	No	No	0	0	0
36	L:L:S25	N:N:K29	3.06	No	No	0	0	0
37	L:L:I63	L:L:V26	3.07	No	No	0	0	0
38	L:L:M66	L:L:V26	6.09	No	No	0	0	0
39	L:L:K27	L:L:K29	4.31	Yes	Yes	3	0	0
40	L:L:K27	N:N:S25	3.06	Yes	No	3	0	0
41	L:L:K27	R:R:S190	6.12	Yes	No	0	0	2
42	L:L:V28	L:L:V40	4.81	No	Yes	0	0	0
43	L:L:V28	N:N:L67	4.47	No	No	0	0	0
44	L:L:H34	L:L:K29	14.41	Yes	Yes	3	0	0
45	L:L:E39	L:L:K29	5.4	No	Yes	0	0	0
46	L:L:K29	N:N:S25	3.06	Yes	No	3	0	0
47	L:L:P31	L:L:S30	3.56	No	No	0	0	0
48	L:L:S30	N:N:M66	6.13	No	Yes	0	0	0
49	L:L:P31	L:L:T38	5.25	No	No	0	0	0
50	L:L:P31	R:R:N202	6.52	No	No	0	0	2
51	L:L:G32	L:L:P33	4.06	No	Yes	0	0	0
52	L:L:H34	L:L:P33	6.1	Yes	Yes	3	0	0
53	L:L:P33	R:R:V187	5.3	Yes	No	3	0	3
54	L:L:P33	R:R:D199	3.22	Yes	No	0	0	4
55	L:L:P33	R:R:T204	3.5	Yes	No	0	0	3
56	L:L:H34	N:N:Q24	4.95	Yes	No	0	0	0
57	L:L:H34	R:R:V187	4.15	Yes	No	3	0	3
58	L:L:H34	R:R:S189	6.97	Yes	No	0	0	1
59	L:L:C35	L:L:E39	4.56	No	No	0	0	0
60	L:L:L52	L:L:V40	5.96	Yes	Yes	4	0	0
61	L:L:V40	L:L:V59	3.21	Yes	No	4	0	0
62	L:L:I41	R:R:P38	3.39	No	Yes	0	0	7
63	L:L:A42	L:L:L52	3.15	No	Yes	0	0	0
64	L:L:K49	L:L:T43	6.01	No	No	0	0	0
65	L:L:L44	L:L:N46	5.49	No	No	0	0	0
66	L:L:N46	L:L:Q48	13.2	No	No	0	0	0
67	L:L:K49	R:R:P38	3.35	No	Yes	0	0	7
68	L:L:C51	R:R:P38	5.65	No	Yes	0	0	7
69	L:L:L52	L:L:V59	4.47	Yes	No	4	0	0
70	L:L:N53	L:L:P54	6.52	Yes	No	0	0	0
71	L:L:A55	L:L:N53	4.69	No	Yes	0	0	0
72	L:L:N53	L:L:S56	4.47	Yes	No	0	0	0
73	L:L:P57	L:L:S56	3.56	No	No	0	0	0
74	L:L:I62	L:L:M58	5.83	No	No	0	0	0
75	L:L:I63	N:N:L67	4.28	No	No	0	0	0
76	L:L:E64	L:L:K68	4.05	No	No	0	0	0
77	L:L:L67	N:N:I63	4.28	No	No	0	0	0
78	L:L:N69	N:N:P31	6.52	No	No	9	0	0
79	L:L:N69	N:N:T38	11.7	No	No	9	0	0
80	N:N:C35	N:N:C9	7.28	No	No	0	0	0
81	N:N:C9	N:N:E39	4.56	No	No	0	0	0
82	N:N:E39	N:N:Q10	7.65	No	No	0	0	0
83	N:N:C11	N:N:E39	7.6	No	No	0	0	0
84	N:N:C11	N:N:I41	3.27	No	No	0	0	0
85	N:N:C11	N:N:C51	7.28	No	No	0	0	0
86	N:N:N53	N:N:T14	4.39	Yes	No	0	0	0
87	N:N:A50	N:N:L15	3.15	No	No	0	0	0
88	N:N:I18	N:N:L44	4.28	No	No	0	0	0
89	N:N:A50	N:N:I18	3.25	No	No	0	0	0
90	N:N:H19	N:N:N22	3.83	No	No	0	0	0
91	N:N:K65	N:N:L20	4.23	No	No	0	0	0
92	N:N:K21	N:N:N22	15.39	No	No	0	0	0
93	N:N:I23	N:N:I62	5.89	No	No	0	0	0
94	N:N:S25	N:N:T43	4.8	No	No	0	0	0
95	N:N:V28	N:N:V40	4.81	No	Yes	0	0	0
96	N:N:H34	N:N:K29	18.34	No	No	0	0	0
97	N:N:P31	N:N:S30	3.56	No	No	0	0	0
98	N:N:P31	N:N:T38	5.25	No	No	9	0	0
99	N:N:G32	N:N:P33	4.06	No	No	0	0	0
100	N:N:G32	N:N:H34	4.77	No	No	0	0	0
101	N:N:P54	N:N:T38	5.25	No	No	0	0	0
102	N:N:L52	N:N:V40	4.47	No	Yes	10	0	0
103	N:N:V40	N:N:V59	6.41	Yes	No	10	0	0
104	N:N:A42	N:N:L52	3.15	No	No	0	0	0
105	N:N:K49	N:N:T43	4.5	No	No	0	0	0
106	N:N:L44	N:N:N46	5.49	No	No	0	0	0
107	N:N:K45	R:R:R185	8.66	No	No	0	0	4
108	N:N:N46	N:N:Q48	13.2	No	No	0	0	0
109	N:N:G47	R:R:Y188	5.79	No	No	0	0	1
110	N:N:L52	N:N:V59	4.47	No	No	10	0	0
111	N:N:N53	N:N:P54	8.15	Yes	No	0	0	0
112	N:N:A55	N:N:N53	4.69	No	Yes	0	0	0
113	N:N:N53	N:N:S56	4.47	Yes	No	0	0	0
114	N:N:P57	N:N:S56	3.56	No	No	0	0	0
115	N:N:I62	N:N:M58	5.83	No	No	0	0	0
116	N:N:I63	N:N:V59	3.07	No	No	0	0	0
117	N:N:E64	N:N:K60	10.8	No	No	0	0	0
118	N:N:K65	N:N:K68	10.06	No	No	0	0	0
119	R:R:C286	R:R:C39	7.28	No	No	0	6	8
120	R:R:C39	R:R:R289	5.57	No	Yes	1	8	3
121	R:R:E40	R:R:P41	7.86	No	No	0	4	4
122	R:R:N191	R:R:P41	8.15	Yes	No	8	2	4
123	R:R:P41	R:R:V192	3.53	No	No	8	4	5
124	R:R:E42	R:R:N290	13.15	No	No	0	4	3
125	R:R:K48	R:R:S43	6.12	No	No	0	4	5
126	R:R:L44	R:R:N47	5.49	No	No	0	2	4
127	R:R:F50	R:R:I54	11.3	No	No	0	5	5
128	R:R:V51	R:R:Y55	5.05	No	No	0	5	7
129	R:R:V109	R:R:V52	4.81	No	No	0	4	5
130	R:R:A105	R:R:Y55	4	No	No	0	7	7
131	R:R:I304	R:R:Y55	7.25	No	No	0	7	7
132	R:R:L57	R:R:L61	4.15	No	No	0	5	5
133	R:R:I304	R:R:V58	4.61	No	No	0	7	7
134	R:R:C308	R:R:V58	5.12	No	No	0	7	7
135	R:R:F59	R:R:P102	13	No	No	0	7	9
136	R:R:C308	R:R:L61	4.76	No	No	0	7	5
137	R:R:A98	R:R:S62	3.42	No	No	0	5	8
138	R:R:S307	R:R:S62	6.52	No	No	0	8	8
139	R:R:C308	R:R:S62	5.16	No	No	0	7	8
140	R:R:D94	R:R:N66	6.73	No	No	0	9	9
141	R:R:L95	R:R:N66	4.12	No	No	0	7	9
142	R:R:N66	R:R:P311	6.52	No	No	0	9	9
143	R:R:L325	R:R:L68	4.15	No	No	0	6	6
144	R:R:I73	R:R:V69	3.07	No	Yes	0	6	8
145	R:R:A91	R:R:V69	3.39	No	Yes	0	8	8
146	R:R:A315	R:R:V69	3.39	No	Yes	0	7	8
147	R:R:F316	R:R:V69	3.93	No	Yes	0	6	8
148	R:R:L92	R:R:M70	4.24	No	No	0	6	6
149	R:R:L71	R:R:Y75	3.52	No	No	11	3	4
150	R:R:I328	R:R:L71	4.28	No	No	11	5	3
151	R:R:L325	R:R:V72	4.47	No	No	0	6	7
152	R:R:I73	R:R:L88	8.56	No	No	0	6	5
153	R:R:F321	R:R:I73	7.54	Yes	No	0	8	6
154	R:R:L74	R:R:R80	3.64	No	No	0	2	7
155	R:R:L74	R:R:L88	8.3	No	No	0	2	5
156	R:R:I328	R:R:Y75	16.92	No	No	11	5	4
157	R:R:R77	R:R:R80	3.2	No	No	0	6	7
158	R:R:D84	R:R:S81	5.89	No	No	0	8	7
159	R:R:D143	R:R:V82	5.84	No	No	12	8	7
160	R:R:R159	R:R:V82	5.23	Yes	No	12	3	7
161	R:R:V162	R:R:V82	3.21	No	No	0	7	7
162	R:R:D84	R:R:F321	3.58	No	Yes	0	8	8
163	R:R:V162	R:R:V85	8.02	No	No	0	7	6
164	R:R:C139	R:R:Y86	5.38	No	Yes	0	5	7
165	R:R:I140	R:R:Y86	6.04	No	Yes	0	9	7
166	R:R:D143	R:R:Y86	8.05	No	Yes	0	8	7
167	R:R:V162	R:R:Y86	8.83	No	Yes	0	7	7
168	R:R:I165	R:R:Y86	4.84	No	Yes	0	5	7
169	R:R:F321	R:R:L87	7.31	Yes	No	0	8	7
170	R:R:C166	R:R:N89	6.3	No	No	0	7	9
171	R:R:N89	R:R:W170	4.52	No	Yes	0	9	9
172	R:R:D94	R:R:L90	5.43	No	Yes	2	9	9
173	R:R:L136	R:R:L90	4.15	No	Yes	0	8	9
174	R:R:L137	R:R:L90	4.15	No	Yes	0	8	9
175	R:R:L90	R:R:N310	6.87	Yes	No	2	9	9
176	R:R:L92	R:R:W170	3.42	No	Yes	0	6	9
177	R:R:D94	R:R:N310	9.42	No	No	2	9	9
178	R:R:L96	R:R:N129	12.36	No	No	0	7	8
179	R:R:F97	R:R:L101	4.87	No	No	0	6	8
180	R:R:F97	R:R:K126	7.44	No	No	0	6	6
181	R:R:F97	R:R:H306	9.05	No	No	0	6	9
182	R:R:T100	R:R:V122	3.17	No	Yes	0	7	5
183	R:R:L125	R:R:T100	4.42	No	No	0	4	7
184	R:R:I304	R:R:L101	7.14	No	No	0	7	8
185	R:R:I103	R:R:W112	3.52	No	Yes	5	6	9
186	R:R:I103	R:R:V122	3.07	No	Yes	5	6	5
187	R:R:W104	R:R:W112	3.75	No	Yes	5	6	9
188	R:R:V122	R:R:W104	3.68	Yes	No	5	5	6
189	R:R:K126	R:R:W104	15.08	No	No	0	6	6
190	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
191	R:R:E300	R:R:K108	4.05	No	No	0	5	5
192	R:R:G111	R:R:S193	3.71	No	No	0	4	3
193	R:R:F114	R:R:W112	10.02	No	Yes	0	6	9
194	R:R:C119	R:R:W112	5.22	No	Yes	5	9	9
195	R:R:V122	R:R:W112	3.68	Yes	Yes	5	5	9
196	R:R:T186	R:R:W112	4.85	Yes	Yes	0	4	9
197	R:R:C196	R:R:W112	9.14	No	Yes	5	9	9
198	R:R:I113	R:R:P194	5.08	No	No	0	3	5
199	R:R:K120	R:R:T116	4.5	No	No	0	7	3
200	R:R:T116	R:R:T186	6.28	No	Yes	0	3	4
201	R:R:F117	R:R:V121	7.87	No	No	0	1	5
202	R:R:C119	R:R:C196	7.28	No	No	5	9	9
203	R:R:S123	R:R:V180	3.23	No	No	1	5	4
204	R:R:R184	R:R:S123	10.54	No	No	1	5	5
205	R:R:L124	R:R:L181	6.92	No	No	0	6	5
206	R:R:L125	R:R:N129	5.49	No	No	0	4	8
207	R:R:E127	R:R:Y131	8.98	No	Yes	0	4	7
208	R:R:A177	R:R:E127	4.53	No	No	0	7	4
209	R:R:E127	R:R:V180	11.41	No	No	0	4	4
210	R:R:A177	R:R:V128	3.39	No	No	0	7	5
211	R:R:F130	R:R:Y131	9.28	No	Yes	0	7	7
212	R:R:F130	R:R:I134	5.02	No	No	6	7	8
213	R:R:F130	R:R:W264	8.02	No	Yes	6	7	8
214	R:R:L176	R:R:Y131	10.55	No	Yes	0	4	7
215	R:R:P215	R:R:Y131	5.56	No	Yes	0	5	7
216	R:R:S132	R:R:W170	16.06	No	Yes	0	6	9
217	R:R:S132	R:R:S173	6.52	No	No	0	6	7
218	R:R:I134	R:R:P223	3.39	No	Yes	0	8	9
219	R:R:I134	R:R:W264	7.05	No	Yes	6	8	8
220	R:R:I169	R:R:L135	11.42	No	No	0	6	6
221	R:R:L137	R:R:Y314	11.72	No	Yes	0	8	9
222	R:R:C139	R:R:I169	3.27	No	No	0	5	6
223	R:R:I140	R:R:R144	7.52	No	No	2	9	9
224	R:R:I140	R:R:Y314	3.63	No	Yes	2	9	9
225	R:R:M227	R:R:S141	4.6	No	No	0	8	9
226	R:R:C230	R:R:S141	5.16	No	No	0	7	9
227	R:R:S141	R:R:Y231	13.99	No	Yes	0	9	9
228	R:R:C230	R:R:V142	3.42	No	No	0	7	6
229	R:R:D143	R:R:R159	11.91	No	Yes	12	8	3
230	R:R:R144	R:R:Y231	8.23	No	Yes	0	9	9
231	R:R:R144	R:R:Y314	6.17	No	Yes	2	9	9
232	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
233	R:R:V149	R:R:Y145	13.88	No	Yes	7	7	8
234	R:R:H150	R:R:Y145	8.71	Yes	Yes	7	6	8
235	R:R:F229	R:R:Y145	3.09	No	Yes	7	4	8
236	R:R:C230	R:R:Y145	5.38	No	Yes	0	7	8
237	R:R:F233	R:R:Y145	3.09	No	Yes	7	4	8
238	R:R:L146	R:R:L155	4.15	No	No	0	5	4
239	R:R:A147	R:R:R159	6.91	No	Yes	0	8	3
240	R:R:I148	R:R:T234	6.08	No	No	0	8	8
241	R:R:H150	R:R:V149	4.15	Yes	No	7	6	7
242	R:R:T237	R:R:V149	7.93	No	No	0	5	7
243	R:R:H150	R:R:R153	6.77	Yes	No	0	6	5
244	R:R:H150	R:R:L155	9	Yes	No	0	6	4
245	R:R:K158	R:R:L155	5.64	No	No	0	6	4
246	R:R:Q157	R:R:T156	7.09	No	No	0	7	2
247	R:R:R159	R:R:T156	3.88	Yes	No	0	3	2
248	R:R:Q157	R:R:Y160	10.15	No	No	0	7	5
249	R:R:F164	R:R:K163	4.96	No	No	0	3	4
250	R:R:F218	R:R:L176	3.65	No	No	0	4	4
251	R:R:L211	R:R:P179	3.28	No	No	0	4	8
252	R:R:R184	R:R:V180	9.15	No	No	1	5	4
253	R:R:F183	R:R:L182	9.74	No	No	0	5	4
254	R:R:F183	R:R:M200	8.71	No	Yes	0	5	5
255	R:R:E198	R:R:R184	11.63	No	No	1	5	5
256	R:R:R185	R:R:V187	6.54	No	No	0	4	3
257	R:R:D199	R:R:R185	16.68	No	No	0	4	4
258	R:R:T186	R:R:Y188	6.24	Yes	No	0	4	1
259	R:R:P194	R:R:Y188	8.34	No	No	0	5	1
260	R:R:N191	R:R:S190	4.47	Yes	No	0	2	2
261	R:R:N191	R:R:V192	4.43	Yes	No	8	2	5
262	R:R:P194	R:R:S193	3.56	No	No	0	5	3
263	R:R:E198	R:R:Y197	6.73	No	No	1	5	3
264	R:R:R208	R:R:Y197	21.61	No	No	1	4	3
265	R:R:E198	R:R:R208	11.63	No	No	1	5	4
266	R:R:M200	R:R:T204	6.02	Yes	No	0	5	3
267	R:R:M200	R:R:W207	4.65	Yes	No	0	5	3
268	R:R:L211	R:R:M200	5.65	No	Yes	0	4	5
269	R:R:N203	R:R:W207	3.39	No	No	0	4	3
270	R:R:M209	R:R:R278	4.96	No	Yes	0	3	4
271	R:R:M209	R:R:T279	4.52	No	No	0	3	1
272	R:R:L271	R:R:R212	9.72	No	Yes	0	6	5
273	R:R:D274	R:R:R212	7.15	Yes	Yes	1	4	5
274	R:R:R212	R:R:T275	9.06	Yes	No	0	5	4
275	R:R:N268	R:R:Q216	7.92	No	No	0	8	5
276	R:R:L271	R:R:Q216	7.99	No	No	0	6	5
277	R:R:F218	R:R:S217	6.61	No	No	0	4	4
278	R:R:F220	R:R:L224	3.65	Yes	Yes	6	8	7
279	R:R:F220	R:R:F260	3.22	Yes	Yes	6	8	9
280	R:R:F220	R:R:L265	7.31	Yes	No	0	8	6
281	R:R:F220	R:R:N268	15.71	Yes	No	0	8	8
282	R:R:P223	R:R:V222	3.53	Yes	No	0	9	5
283	R:R:I226	R:R:V222	3.07	No	No	0	6	5
284	R:R:L224	R:R:L228	6.92	Yes	No	0	7	4
285	R:R:F260	R:R:L224	3.65	Yes	Yes	6	9	7
286	R:R:L224	R:R:L261	4.15	Yes	No	0	7	6
287	R:R:F260	R:R:M227	9.95	Yes	No	0	9	8
288	R:R:F229	R:R:F233	10.72	No	No	7	4	4
289	R:R:I253	R:R:Y231	10.88	No	Yes	0	7	9
290	R:R:V256	R:R:Y231	3.79	Yes	Yes	0	8	9
291	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
292	R:R:L235	R:R:M250	4.24	No	No	0	4	5
293	R:R:I253	R:R:L235	8.56	No	No	0	7	4
294	R:R:F239	R:R:M250	3.73	No	No	0	5	5
295	R:R:A241	R:R:M243	4.83	No	Yes	0	3	4
296	R:R:H247	R:R:K246	9.17	No	No	0	5	7
297	R:R:R248	R:R:R322	3.2	No	No	0	7	8
298	R:R:I317	R:R:V252	7.68	No	No	0	6	7
299	R:R:I313	R:R:V256	3.07	No	Yes	2	7	8
300	R:R:V256	R:R:Y314	10.09	Yes	Yes	2	8	9
301	R:R:I259	R:R:I313	5.89	No	No	0	6	7
302	R:R:F260	R:R:W264	5.01	Yes	Yes	6	9	8
303	R:R:C263	R:R:W264	3.92	No	Yes	0	7	8
304	R:R:H306	R:R:W264	7.41	No	Yes	0	9	8
305	R:R:L265	R:R:P266	3.28	No	No	0	6	9
306	R:R:L265	R:R:L269	6.92	No	No	0	6	6
307	R:R:L302	R:R:P266	3.28	No	No	0	7	9
308	R:R:L271	R:R:Y267	3.52	No	No	0	6	7
309	R:R:T299	R:R:Y267	7.49	No	No	0	6	7
310	R:R:E300	R:R:Y267	6.73	No	No	0	5	7
311	R:R:A295	R:R:V270	5.09	No	No	0	5	4
312	R:R:L296	R:R:V270	5.96	No	No	0	5	4
313	R:R:T299	R:R:V270	4.76	No	No	0	6	4
314	R:R:L272	R:R:L276	4.15	No	No	0	5	4
315	R:R:D274	R:R:R278	11.91	Yes	Yes	1	4	4
316	R:R:D274	R:R:I292	4.2	Yes	No	0	4	5
317	R:R:L276	R:R:V281	5.96	No	No	0	4	4
318	R:R:I282	R:R:L276	4.28	No	No	0	5	4
319	R:R:E284	R:R:M277	9.47	Yes	No	0	3	4
320	R:R:M277	R:R:R288	4.96	No	No	0	4	1
321	R:R:I292	R:R:M277	5.83	No	No	0	5	4
322	R:R:I282	R:R:R288	6.26	No	No	0	5	1
323	R:R:E284	R:R:R289	13.96	Yes	Yes	1	3	3
324	R:R:D293	R:R:R294	3.57	No	No	0	4	2
325	R:R:D297	R:R:I301	4.2	No	No	0	4	5
326	R:R:H306	R:R:S307	5.58	No	No	0	9	8
327	R:R:N310	R:R:Y314	5.81	No	Yes	2	9	9
328	R:R:I313	R:R:Y314	3.63	No	Yes	2	7	9
329	R:R:A315	R:R:F321	4.16	No	Yes	0	7	8
330	R:R:H323	R:R:K327	6.55	No	No	0	4	4
331	L:L:V28	N:N:M66	3.04	No	Yes	0	0	0
332	L:L:M66	N:N:V28	3.04	No	No	0	0	0
333	N:N:M66	N:N:V26	3.04	Yes	No	0	0	0
334	R:R:I253	R:R:T234	3.04	No	No	0	7	8
335	L:L:Q13	R:R:A36	3.03	No	No	0	0	5
336	R:R:L63	R:R:S67	3	No	No	0	5	3
337	R:R:L124	R:R:V128	2.98	No	No	0	6	5
338	N:N:C35	N:N:H34	2.95	No	No	0	0	0
339	R:R:L87	R:R:T83	2.95	No	No	0	7	7
340	R:R:L238	R:R:T234	2.95	No	No	0	8	8
341	L:L:I18	L:L:I23	2.94	Yes	Yes	4	0	0
342	L:L:I23	L:L:I62	2.94	Yes	No	0	0	0
343	N:N:I18	N:N:I23	2.94	No	No	0	0	0
344	N:N:I23	N:N:M66	2.92	No	Yes	0	0	0
345	R:R:D297	R:R:V51	2.92	No	No	0	4	5
346	R:R:K246	R:R:M243	2.88	No	Yes	0	7	4
347	L:L:K65	L:L:K68	2.87	No	No	0	0	0
348	L:L:I18	L:L:L52	2.85	Yes	Yes	4	0	0
349	R:R:I165	R:R:L161	2.85	No	No	0	5	4
350	R:R:I221	R:R:L225	2.85	No	No	0	4	3
351	R:R:I259	R:R:L309	2.85	No	No	0	6	6
352	L:L:K65	L:L:L20	2.82	No	No	0	0	0
353	L:L:K21	L:L:N22	2.8	No	No	0	0	0
354	R:R:L92	R:R:L96	2.77	No	No	0	6	7
355	R:R:A106	R:R:F114	2.77	No	No	0	4	6
356	R:R:L135	R:R:L172	2.77	No	No	0	6	4
357	R:R:L172	R:R:L176	2.77	No	No	0	4	4
358	R:R:E45	R:R:K48	2.7	No	No	0	4	4
359	R:R:A93	R:R:W170	2.59	No	Yes	0	8	9
360	R:R:F114	R:R:L118	2.44	No	No	0	6	6
361	R:R:F254	R:R:L235	2.44	No	No	0	4	4
362	R:R:L87	R:R:Y314	2.34	No	Yes	0	7	9
363	R:R:L210	R:R:W207	2.28	No	No	0	2	3
364	R:R:G65	R:R:P311	2.03	No	No	0	7	9
365	R:R:G219	R:R:P223	2.03	No	Yes	0	5	9
366	R:R:A37	R:R:P38	1.87	No	Yes	0	7	7
367	R:R:A138	R:R:P223	1.87	No	Yes	0	7	9
368	R:R:G133	R:R:S132	1.86	No	No	0	9	6
369	R:R:G324	R:R:V72	1.84	No	No	0	5	7
370	R:R:G79	R:R:V78	1.84	No	No	0	6	5
371	R:R:G115	R:R:T186	1.82	No	Yes	0	8	4
372	R:R:G201	R:R:T204	1.82	No	No	0	4	3
373	L:L:P54	L:L:V40	1.77	No	Yes	0	0	0
374	N:N:P54	N:N:V40	1.77	No	Yes	0	0	0
375	R:R:G318	R:R:I317	1.76	No	No	0	7	6
376	L:L:G17	L:L:M58	1.75	No	No	0	0	0
377	R:R:G244	R:R:M243	1.75	No	Yes	0	4	4
378	R:R:G324	R:R:K327	1.74	No	No	0	5	4
379	R:R:G65	R:R:L64	1.71	No	No	0	7	4
380	R:R:G171	R:R:L174	1.71	No	No	0	4	5
381	R:R:G303	R:R:L302	1.71	No	No	0	7	7
382	L:L:A4	R:R:V192	1.7	No	No	0	0	5
383	L:L:G47	L:L:N46	1.7	No	No	0	0	0
384	N:N:G47	N:N:N46	1.7	No	No	0	0	0
385	R:R:A105	R:R:V52	1.7	No	No	0	7	5
386	N:N:G17	N:N:Q16	1.64	No	No	0	0	0
387	R:R:L101	R:R:P102	1.64	No	No	0	8	9
388	R:R:L178	R:R:P179	1.64	No	No	0	3	8
389	R:R:L214	R:R:P215	1.64	No	No	0	3	5
390	R:R:G244	R:R:Q245	1.64	No	No	0	4	4
391	R:R:V252	R:R:V256	1.6	No	Yes	0	7	8
392	R:R:A249	R:R:L238	1.58	No	No	0	7	8
393	L:L:A36	R:R:N203	1.56	No	No	0	0	4
394	R:R:A205	R:R:N206	1.56	No	No	0	1	1
395	N:N:C35	N:N:Q37	1.53	No	No	0	0	0
396	R:R:K320	R:R:S81	1.53	No	No	0	6	7
397	N:N:A36	N:N:Q37	1.52	No	No	0	0	0
398	R:R:G318	R:R:R322	1.5	No	No	0	7	8
399	R:R:L305	R:R:V58	1.49	No	No	0	5	7
400	R:R:L174	R:R:V128	1.49	No	No	0	5	5
401	R:R:N110	R:R:V109	1.48	No	No	0	4	4
402	R:R:I301	R:R:I54	1.47	No	No	0	5	5
403	L:L:K61	L:L:M58	1.44	No	No	0	0	0
404	L:L:K60	L:L:K61	1.44	No	No	0	0	0
405	L:L:I18	L:L:L44	1.43	Yes	No	4	0	0
406	L:L:I18	R:R:L33	1.43	Yes	No	0	0	3
407	L:L:I23	L:L:L44	1.43	Yes	No	4	0	0
408	N:N:I62	N:N:L20	1.43	No	No	0	0	0
409	R:R:I213	R:R:L214	1.43	No	No	0	4	3
410	L:L:Q24	L:L:T43	1.42	No	No	0	0	0
411	R:R:I46	R:R:N47	1.42	No	No	0	5	4
412	L:L:E6	L:L:T5	1.41	Yes	No	0	0	0
413	L:L:T5	R:R:E300	1.41	No	No	0	0	5
414	L:L:L67	N:N:K60	1.41	No	No	0	0	0
415	R:R:L238	R:R:M243	1.41	No	Yes	0	8	4
416	R:R:E287	R:R:T285	1.41	No	No	0	4	5
417	L:L:L15	R:R:L33	1.38	No	No	0	0	3
418	R:R:L63	R:R:L95	1.38	No	No	0	5	7
419	R:R:L172	R:R:L175	1.38	No	No	0	4	4
420	R:R:L175	R:R:L178	1.38	No	No	0	4	3
421	L:L:K45	L:L:Q24	1.36	No	No	0	0	0
422	N:N:E64	N:N:K61	1.35	No	No	0	0	0
423	N:N:L12	N:N:Q13	1.33	No	No	0	0	0
424	N:N:L15	N:N:Q13	1.33	No	No	0	0	0
425	R:R:F321	R:R:V72	1.31	Yes	No	0	8	7
426	R:R:R288	R:R:T285	1.29	No	No	0	1	5
427	R:R:E284	R:R:Q280	1.27	Yes	No	0	3	2
428	R:R:V52	R:R:Y49	1.26	No	No	0	5	2
429	R:R:F220	R:R:I221	1.26	Yes	No	0	8	4
430	R:R:F59	R:R:L60	1.22	No	No	0	7	4
431	R:R:F117	R:R:L118	1.22	No	No	0	1	6
432	R:R:F316	R:R:L312	1.22	No	No	0	6	6
433	R:R:Q319	R:R:R322	1.17	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E6	5.52	7	1	0
2	L:L:R8	7.916	5	1	0
3	L:L:Q10	5.9975	4	0	0
4	L:L:I18	2.38	5	4	0
5	L:L:I23	2.8975	4	4	0
6	L:L:K27	4.39	4	3	0
7	L:L:K29	6.795	4	3	0
8	L:L:P33	4.436	5	3	0
9	L:L:H34	6.95333	6	3	0
10	L:L:V40	3.9375	4	4	0
11	L:L:L52	4.1075	4	4	0
12	L:L:N53	5.0175	4	0	0
13	N:N:V40	4.365	4	10	0
14	N:N:N53	5.425	4	0	0
15	N:N:M66	3.7825	4	0	0
16	R:R:P38	3.565	4	0	7
17	R:R:V69	3.445	4	0	8
18	R:R:Y86	6.628	5	0	7
19	R:R:L90	5.15	4	2	9
20	R:R:W112	5.94875	8	5	9
21	R:R:V122	3.4	4	5	5
22	R:R:Y131	8.5925	4	0	7
23	R:R:Y145	6.27833	6	7	8
24	R:R:H150	7.1575	4	7	6
25	R:R:R159	6.9825	4	12	3
26	R:R:W170	6.6475	4	0	9
27	R:R:T186	4.7975	4	0	4
28	R:R:N191	6.5725	4	8	2
29	R:R:M200	6.2575	4	0	5
30	R:R:R212	7.355	4	1	5
31	R:R:F220	6.23	5	6	8
32	R:R:P223	2.705	4	0	9
33	R:R:L224	4.5925	4	6	7
34	R:R:Y231	8.388	5	0	9
35	R:R:M243	2.7175	4	0	4
36	R:R:V256	4.6375	4	2	8
37	R:R:F260	5.4575	4	6	9
38	R:R:W264	6.282	5	6	8
39	R:R:D274	8.096	5	1	4
40	R:R:R278	8.3625	4	1	4
41	R:R:E284	7.8325	4	1	3
42	R:R:R289	8.265	4	1	3
43	R:R:Y314	6.19857	7	2	9
44	R:R:F321	4.78	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T186	R:R:Y188	70.7125	6.24	Yes	No	0	4	1
2	R:R:T186	R:R:W112	73.142	4.85	Yes	Yes	0	4	9
3	R:R:W104	R:R:W112	76.0236	3.75	No	Yes	5	6	9
4	R:R:K126	R:R:W104	87.6001	15.08	No	No	0	6	6
5	R:R:F97	R:R:K126	88.0945	7.44	No	No	0	6	6
6	R:R:F97	R:R:H306	95.71	9.05	No	No	0	6	9
7	R:R:H306	R:R:W264	100	7.41	No	Yes	0	9	8
8	R:R:F260	R:R:W264	77.763	5.01	Yes	Yes	6	9	8
9	R:R:F220	R:R:F260	44.4962	3.22	Yes	Yes	6	8	9
10	R:R:F220	R:R:N268	42.321	15.71	Yes	No	0	8	8
11	R:R:N268	R:R:Q216	41.9517	7.92	No	No	0	8	5
12	R:R:L271	R:R:Q216	41.5885	7.99	No	No	0	6	5
13	R:R:L271	R:R:R212	37.1249	9.72	No	Yes	0	6	5
14	L:L:E6	R:R:R212	21.2725	3.49	Yes	Yes	1	0	5
15	R:R:D274	R:R:R212	15.2451	7.15	Yes	Yes	1	4	5
16	R:R:F130	R:R:W264	51.4216	8.02	No	Yes	6	7	8
17	R:R:F130	R:R:Y131	52.9532	9.28	No	Yes	0	7	7
18	R:R:E127	R:R:Y131	47.1841	8.98	No	Yes	0	4	7
19	R:R:E127	R:R:V180	43.7234	11.41	No	No	0	4	4
20	R:R:R184	R:R:V180	42.4905	9.15	No	No	1	5	4
21	R:R:E198	R:R:R184	42.2887	11.63	No	No	1	5	5
22	R:R:E198	R:R:Y197	39.1751	6.73	No	No	1	5	3
23	L:L:L7	R:R:Y197	55.9659	15.24	No	No	0	0	3
24	L:L:H34	L:L:L7	55.078	5.14	Yes	No	0	0	0
25	L:L:H34	L:L:K29	61.4787	14.41	Yes	Yes	3	0	0
26	L:L:E39	L:L:K29	27.6005	5.4	No	Yes	0	0	0
27	L:L:K27	L:L:K29	30.8231	4.31	Yes	Yes	3	0	0
28	L:L:K27	L:L:Q10	25.4515	4.07	Yes	Yes	0	0	0
29	L:L:E39	L:L:Q10	25.3425	3.82	No	Yes	0	0	0
30	L:L:I41	L:L:Q10	41.3019	6.86	No	Yes	0	0	0
31	L:L:I41	R:R:P38	36.4429	3.39	No	Yes	0	0	7
32	N:N:G47	R:R:Y188	63.6923	5.79	No	No	0	0	1
33	N:N:G47	N:N:N46	63.0486	1.7	No	No	0	0	0
34	N:N:L44	N:N:N46	61.7128	5.49	No	No	0	0	0
35	N:N:I18	N:N:L44	61.0388	4.28	No	No	0	0	0
36	N:N:I18	N:N:I23	57.6084	2.94	No	No	0	0	0
37	N:N:I23	N:N:M66	53.3487	2.92	No	Yes	0	0	0
38	L:L:V28	N:N:M66	48.9699	3.04	No	Yes	0	0	0
39	L:L:V28	L:L:V40	29.12	4.81	No	Yes	0	0	0
40	L:L:L52	L:L:V40	21.3007	5.96	Yes	Yes	4	0	0
41	L:L:I18	L:L:L52	19.5754	2.85	Yes	Yes	4	0	0
42	L:L:K49	R:R:P38	31.6282	3.35	No	Yes	0	0	7
43	L:L:K49	L:L:T43	29.9998	6.01	No	No	0	0	0
44	L:L:S25	L:L:T43	25.0903	4.8	No	No	0	0	0
45	L:L:S25	N:N:K29	21.7971	3.06	No	No	0	0	0
46	L:L:V28	N:N:L67	22.2148	4.47	No	No	0	0	0
47	L:L:I63	N:N:L67	21.335	4.28	No	No	0	0	0
48	L:L:I63	L:L:V26	20.4573	3.07	No	No	0	0	0
49	L:L:M66	L:L:V26	19.5754	6.09	No	No	0	0	0
50	L:L:H34	L:L:P33	15.4529	6.1	Yes	Yes	3	0	0
51	R:R:L176	R:R:Y131	11.6593	10.55	No	Yes	0	4	7
52	R:R:L172	R:R:L176	10.1156	2.77	No	No	0	4	4
53	R:R:L172	R:R:L175	18.9438	1.38	No	No	0	4	4
54	R:R:L175	R:R:L178	18.4817	1.38	No	No	0	4	3
55	R:R:L178	R:R:P179	18.0862	1.64	No	No	0	3	8
56	R:R:L211	R:R:P179	17.7694	3.28	No	No	0	4	8
57	R:R:L211	R:R:M200	17.4587	5.65	No	Yes	0	4	5
58	R:R:M200	R:R:T204	15.241	6.02	Yes	No	0	5	3
59	L:L:M66	N:N:V28	18.6835	3.04	No	No	0	0	0
60	N:N:V28	N:N:V40	17.7876	4.81	No	Yes	0	0	0
61	N:N:H34	N:N:K29	20.1445	18.34	No	No	0	0	0
62	N:N:C35	N:N:H34	15.1623	2.95	No	No	0	0	0
63	N:N:C35	N:N:C9	10.1439	7.28	No	No	0	0	0
64	R:R:F97	R:R:L101	17.378	4.87	No	No	0	6	8
65	R:R:I304	R:R:L101	13.8184	7.14	No	No	0	7	8
66	R:R:I304	R:R:Y55	10.4526	7.25	No	No	0	7	7
67	R:R:F260	R:R:M227	82.7956	9.95	Yes	No	0	9	8
68	R:R:M227	R:R:S141	82.2326	4.6	No	No	0	8	9
69	R:R:S141	R:R:Y231	73.1219	13.99	No	Yes	0	9	9
70	R:R:R144	R:R:Y231	31.3962	8.23	No	Yes	0	9	9
71	R:R:R144	R:R:Y314	22.6608	6.17	No	Yes	2	9	9
72	R:R:N310	R:R:Y314	16.026	5.81	No	Yes	2	9	9
73	R:R:D94	R:R:N310	11.6694	9.42	No	No	2	9	9
74	R:R:V256	R:R:Y231	31.382	3.79	Yes	Yes	0	8	9
75	R:R:V256	R:R:Y314	23.7383	10.09	Yes	Yes	2	8	9
76	R:R:D94	R:R:N66	10.267	6.73	No	No	0	9	9
77	R:R:L87	R:R:Y314	37.2056	2.34	No	Yes	0	7	9
78	R:R:F321	R:R:L87	34.4512	7.31	Yes	No	0	8	7
79	R:R:F321	R:R:I73	13.1202	7.54	Yes	No	0	8	6
80	R:R:T100	R:R:V122	12.3272	3.17	No	Yes	0	7	5
81	R:R:L125	R:R:T100	11.403	4.42	No	No	0	4	7
82	R:R:L125	R:R:N129	10.4748	5.49	No	No	0	4	8
83	R:R:I140	R:R:Y86	20.5844	6.04	No	Yes	0	9	7
84	R:R:L135	R:R:L172	17.7513	2.77	No	No	0	6	4
85	R:R:I169	R:R:L135	17.2892	11.42	No	No	0	6	6
86	R:R:C139	R:R:I169	16.8271	3.27	No	No	0	5	6
87	R:R:C230	R:R:S141	15.7051	5.16	No	No	0	7	9
88	R:R:C230	R:R:Y145	13.5097	5.38	No	Yes	0	7	8
89	R:R:I253	R:R:Y231	16.8876	10.88	No	Yes	0	7	9
90	R:R:I253	R:R:T234	11.3586	3.04	No	No	0	7	8
91	L:L:E6	R:R:R208	20.1122	11.63	Yes	No	1	0	4
92	R:R:R208	R:R:Y197	17.6766	21.61	No	No	1	4	3
93	L:L:P33	R:R:T204	14.7043	3.5	Yes	No	0	0	3
94	R:R:V122	R:R:W104	11.0761	3.68	Yes	No	5	5	6
95	R:R:C139	R:R:Y86	16.4397	5.38	No	Yes	0	5	7
96	R:R:I140	R:R:Y314	12.7247	3.63	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P2	R:R:S43	3.56	0	No	No	0	5	0	1
L:L:L3	R:R:K48	9.87	0	No	No	0	4	0	1
L:L:L3	R:R:S193	4.5	0	No	No	0	3	0	1
L:L:E6	R:R:R208	11.63	1	Yes	No	0	4	0	1
L:L:E6	R:R:R212	3.49	1	Yes	Yes	0	5	0	1
L:L:E6	R:R:D274	6.5	1	Yes	Yes	0	4	0	1
L:L:E6	R:R:R278	6.98	1	Yes	Yes	0	4	0	1
L:L:E6	R:R:L296	3.98	1	Yes	No	0	5	0	1
L:L:L7	R:R:Y197	15.24	0	No	No	0	3	0	1
L:L:R8	R:R:D274	10.72	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:R278	9.6	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:R289	7.46	1	Yes	Yes	0	3	0	1
L:L:R8	R:R:D293	7.15	1	Yes	No	0	4	0	1
L:L:Q10	R:R:N191	9.24	0	Yes	Yes	0	2	0	1
L:L:L12	R:R:C39	3.17	1	No	No	0	8	0	1
L:L:L12	R:R:E284	6.63	1	No	Yes	0	3	0	1
L:L:L12	R:R:R289	6.07	1	No	Yes	0	3	0	1
L:L:Q13	R:R:D35	7.83	0	No	No	0	6	0	1
L:L:L15	R:R:A36	4.73	0	No	No	0	5	0	1
L:L:K27	R:R:S190	6.12	3	Yes	No	0	2	0	1
L:L:P31	R:R:N202	6.52	0	No	No	0	2	0	1
L:L:P33	R:R:V187	5.3	3	Yes	No	0	3	0	1
L:L:P33	R:R:D199	3.22	3	Yes	No	0	4	0	1
L:L:P33	R:R:T204	3.5	3	Yes	No	0	3	0	1
L:L:H34	R:R:V187	4.15	3	Yes	No	0	3	0	1
L:L:H34	R:R:S189	6.97	3	Yes	No	0	1	0	1
L:L:I41	R:R:P38	3.39	0	No	Yes	0	7	0	1
L:L:K49	R:R:P38	3.35	0	No	Yes	0	7	0	1
L:L:C51	R:R:P38	5.65	0	No	Yes	0	7	0	1
N:N:K45	R:R:R185	8.66	0	No	No	0	4	0	1
N:N:G47	R:R:Y188	5.79	0	No	No	0	1	0	1
R:R:C286	R:R:C39	7.28	0	No	No	6	8	2	1
R:R:C39	R:R:R289	5.57	1	No	Yes	8	3	1	1
R:R:N191	R:R:P41	8.15	8	Yes	No	2	4	1	2
R:R:P41	R:R:V192	3.53	8	No	No	4	5	2	1
R:R:K48	R:R:S43	6.12	0	No	No	4	5	1	1
R:R:E300	R:R:K108	4.05	0	No	No	5	5	1	2
R:R:G111	R:R:S193	3.71	0	No	No	4	3	2	1
R:R:R185	R:R:V187	6.54	0	No	No	4	3	1	1
R:R:D199	R:R:R185	16.68	0	No	No	4	4	1	1
R:R:T186	R:R:Y188	6.24	0	Yes	No	4	1	2	1
R:R:P194	R:R:Y188	8.34	0	No	No	5	1	2	1
R:R:N191	R:R:S190	4.47	8	Yes	No	2	2	1	1
R:R:N191	R:R:V192	4.43	8	Yes	No	2	5	1	1
R:R:P194	R:R:S193	3.56	0	No	No	5	3	2	1
R:R:E198	R:R:Y197	6.73	1	No	No	5	3	2	1
R:R:R208	R:R:Y197	21.61	1	No	No	4	3	1	1
R:R:E198	R:R:R208	11.63	1	No	No	5	4	2	1
R:R:M200	R:R:T204	6.02	0	Yes	No	5	3	2	1
R:R:M200	R:R:W207	4.65	0	Yes	No	5	3	2	2
R:R:N203	R:R:W207	3.39	0	No	No	4	3	1	2
R:R:M209	R:R:R278	4.96	0	No	Yes	3	4	2	1
R:R:L271	R:R:R212	9.72	0	No	Yes	6	5	2	1
R:R:D274	R:R:R212	7.15	1	Yes	Yes	4	5	1	1
R:R:R212	R:R:T275	9.06	1	Yes	No	5	4	1	2
R:R:L271	R:R:Y267	3.52	0	No	No	6	7	2	2
R:R:E300	R:R:Y267	6.73	0	No	No	5	7	1	2
R:R:L296	R:R:V270	5.96	0	No	No	5	4	1	2
R:R:D274	R:R:R278	11.91	1	Yes	Yes	4	4	1	1
R:R:D274	R:R:I292	4.2	1	Yes	No	4	5	1	2
R:R:E284	R:R:M277	9.47	1	Yes	No	3	4	1	2
R:R:I292	R:R:M277	5.83	0	No	No	5	4	2	2
R:R:E284	R:R:R289	13.96	1	Yes	Yes	3	3	1	1
R:R:D293	R:R:R294	3.57	0	No	No	4	2	1	2
L:L:Q13	R:R:A36	3.03	0	No	No	0	5	0	1
R:R:E45	R:R:K48	2.7	0	No	No	4	4	2	1
R:R:A37	R:R:P38	1.87	0	No	Yes	7	7	2	1
R:R:G201	R:R:T204	1.82	0	No	No	4	3	2	1
L:L:A4	R:R:V192	1.7	0	No	No	0	5	0	1
L:L:A36	R:R:N203	1.56	0	No	No	0	4	0	1
L:L:I18	R:R:L33	1.43	4	Yes	No	0	3	0	1
L:L:T5	R:R:E300	1.41	0	No	No	0	5	0	1
L:L:L15	R:R:L33	1.38	0	No	No	0	3	0	1
R:R:E284	R:R:Q280	1.27	1	Yes	No	3	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XXH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.06
Number of Linked Nodes	400
Number of Links	433
Number of Hubs	44
Number of Links mediated by Hubs	172
Number of Communities	12
Number of Nodes involved in Communities	67
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	109519
Length Of Smallest Path	3
Average Path Length	19.4858
Length of Longest Path	51
Minimum Path Strength	1.33
Average Path Strength	6.56523
Maximum Path Strength	18.425
Minimum Path Correlation	0.7
Average Path Correlation	0.951183
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	49.408
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.3035
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • immune response • immune system process • defense response • response to stress • inflammatory response • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to biotic stimulus • cellular anatomical structure • extracellular region • extracellular space • G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • protein binding • binding • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • regulation of biological process • regulation of cellular process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • neutrophil activation • multicellular organismal process • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • cellular response to stimulus • neutrophil chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular defense response • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to interleukin-8 • response to interleukin-8 • cellular response to cytokine stimulus • interleukin-8-mediated signaling pathway • cell periphery • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • mast cell granule • organelle • cytoplasm • lysosome • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • organelle membrane • secretory granule membrane • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • secretion • export from cell • membrane docking • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Interleukin 8-like chemokines • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Interleukin 8-like chemokines • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XXH_nogp_Chain_R L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XXH_nogp.zip

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