Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:E31 5.4575437
2L:L:Y40 9.9404
3L:L:H60 4.408568
4L:L:C61 6.3725469
5L:L:D72 8.1475474
6L:L:R74 7.88472
7L:L:P80 4.5275489
8L:L:W84 10.3375403
9R:R:V82 6.8325497
10R:R:Y86 5.954507
11R:R:L101 4.248548
12R:R:W104 5.585406
13R:R:K108 3.8405
14R:R:W112 7.31409
15R:R:V128 3.8625405
16R:R:N129 5.8025408
17R:R:F130 10.625417
18R:R:Y131 7.65143717
19R:R:I134 4.9025418
20R:R:L137 5.845408
21R:R:Y145 5.68833628
22R:R:T154 4.1625405
23R:R:K158 5.83496
24R:R:V162 4.4025407
25R:R:W170 5.7325409
26R:R:R184 11.1065105
27R:R:Y197 7.29403
28R:R:D199 4.8425404
29R:R:Q216 7.3175415
30R:R:F218 3.77414
31R:R:Y231 6.624529
32R:R:M243 3.0354114
33R:R:V256 4.3225428
34R:R:F260 6.1075419
35R:R:W264 7.99571718
36R:R:Y267 8.306507
37R:R:M277 3.065404
38R:R:R278 5.252534
39R:R:R289 10.185433
40R:R:H306 8.035419
41R:R:N310 7.39409
42R:R:I313 3.4175427
43R:R:Y314 8.0775429
44R:R:F321 4.2225408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:K30 R:R:W104 12.12613.48NoYes016
2L:L:K30 R:R:Y197 12.59623.58NoYes013
3R:R:R208 R:R:Y197 85.3434.12NoYes043
4R:R:R208 R:R:R278 94.87494.26NoYes044
5L:L:E31 R:R:R278 62.87424.65YesYes374
6L:L:E31 R:R:D274 36.07453.9YesNo374
7L:L:E31 R:R:L296 34.9213.98YesNo075
8L:L:L32 R:R:Y197 86.434216.41NoYes083
9L:L:H60 L:L:L32 85.49975.14YesNo088
10L:L:E65 L:L:H60 77.86993.69NoYes698
11L:L:E65 L:L:I55 77.228412.3NoNo096
12L:L:I55 L:L:R53 75.31082.51NoNo064
13L:L:I67 L:L:R53 72.41975.01NoNo094
14L:L:E75 L:L:I67 15.24892.73NoNo049
15L:L:E75 R:R:A37 14.17226.03NoNo047
16R:R:A37 R:R:P38 13.09371.87NoNo077
17L:L:Q35 R:R:P38 12.013214.21NoNo047
18L:L:Q35 R:R:E40 10.93073.82NoNo044
19L:L:C77 L:L:I67 57.70131.64NoNo099
20L:L:C36 L:L:C77 56.70457.28NoNo099
21L:L:C36 L:L:T39 55.70091.69NoNo098
22L:L:D79 L:L:T39 54.70024.34NoNo068
23L:L:D79 L:L:P80 52.6936.44NoYes069
24L:L:P80 L:L:Q86 49.66563.16YesNo097
25L:L:E90 L:L:Q86 48.65333.82NoNo037
26L:L:E90 L:L:V89 47.63898.56NoNo035
27L:L:I66 L:L:V89 46.61971.54NoNo095
28L:L:I66 L:L:V68 44.58433.07NoNo098
29L:L:L78 L:L:V68 29.06192.98NoNo098
30L:L:L76 L:L:L78 28.01162.77NoNo049
31L:L:L76 L:L:Y40 26.95835.86NoYes044
32L:L:F44 L:L:Y40 16.25054.13NoYes084
33L:L:F44 L:L:W84 15.181712.03NoYes083
34L:L:I49 L:L:V68 15.23233.07NoNo098
35L:L:F48 L:L:I49 11.99662.51NoNo039
36R:R:K126 R:R:W104 19.73069.28NoYes066
37R:R:F97 R:R:K126 20.28158.69NoNo066
38R:R:F97 R:R:N129 20.47046.04NoYes068
39R:R:N129 R:R:V128 22.78324.43YesYes085
40R:R:S173 R:R:V128 23.42574.85NoYes075
41R:R:S173 R:R:Y131 29.99543.82NoYes077
42R:R:F130 R:R:Y131 22.77749.28YesYes177
43R:R:F130 R:R:W264 23.528911.02YesYes178
44R:R:F260 R:R:W264 66.56937.02YesYes198
45R:R:F260 R:R:L137 52.07973.65YesYes098
46R:R:L137 R:R:L90 53.13884.15YesNo089
47R:R:L90 R:R:N310 35.31919.61NoYes099
48R:R:D94 R:R:N310 38.11298.08NoYes099
49R:R:D94 R:R:N66 28.76998.08NoNo099
50R:R:L95 R:R:N66 53.61194.12NoNo079
51R:R:L63 R:R:L95 38.33294.15NoNo057
52R:R:F59 R:R:L63 34.50836.09NoNo075
53R:R:F59 R:R:L101 23.02277.31NoYes078
54R:R:H306 R:R:W264 51.601816.93YesYes198
55R:R:H306 R:R:L137 52.15473.86YesYes098
56R:R:L137 R:R:Y314 50.719911.72YesYes089
57R:R:N310 R:R:Y314 35.6916.98YesYes099
58R:R:N310 R:R:P311 30.56394.89YesNo099
59R:R:N66 R:R:P311 28.66779.77NoNo099
60R:R:L95 R:R:S67 11.51966.01NoNo073
61R:R:S132 R:R:S173 16.10653.26NoNo067
62R:R:S132 R:R:W170 15.123313.59NoYes069
63R:R:N89 R:R:W170 13.63395.65NoYes099
64R:R:L88 R:R:N89 12.63134.12NoNo059
65R:R:I73 R:R:L88 12.12714.28NoNo065
66R:R:F321 R:R:I73 11.11273.77YesNo086
67R:R:C139 R:R:L136 20.96973.17NoNo058
68R:R:C139 R:R:Y86 20.13659.41NoYes057
69R:R:F260 R:R:M227 15.55456.22YesNo098
70R:R:M227 R:R:S141 15.07566.13NoNo089
71R:R:S123 R:R:W104 11.03684.94NoYes056
72R:R:R184 R:R:S123 10.578313.18YesNo055
73R:R:C230 R:R:S141 10.88013.44NoNo279
74R:R:C230 R:R:Y145 12.52714.03NoYes278
75R:R:D199 R:R:R208 12.55932.38YesNo044
76R:R:M209 R:R:R278 31.85377.44NoYes034
77R:R:M209 R:R:T275 32.02217.53NoNo034
78R:R:D274 R:R:R212 36.231313.1NoNo345
79R:R:L271 R:R:R212 68.484110.93NoNo065
80R:R:R212 R:R:T275 32.20716.47NoNo354
81R:R:L296 R:R:V270 35.14392.98NoNo054
82R:R:T299 R:R:V270 35.70273.17NoNo064
83R:R:V256 R:R:Y314 10.17047.57YesYes289
84R:R:L271 R:R:Y267 64.00923.52NoYes067
85R:R:T299 R:R:Y267 39.00077.49NoYes067
86R:R:W264 R:R:Y267 1006.75YesYes087
87R:R:L136 R:R:L90 19.7154.15NoNo089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:A29 R:R:K108 3.21 0 No Yes 2 5 0 1
L:L:K30 R:R:W104 3.48 0 No Yes 1 6 0 1
L:L:K30 R:R:Y197 3.58 0 No Yes 1 3 0 1
L:L:E31 R:R:D274 3.9 3 Yes No 7 4 0 1
L:L:E31 R:R:R278 4.65 3 Yes Yes 7 4 0 1
L:L:E31 R:R:R289 9.3 3 Yes Yes 7 3 0 1
L:L:E31 R:R:L296 3.98 3 Yes No 7 5 0 1
L:L:L32 R:R:Y197 16.41 0 No Yes 8 3 0 1
L:L:R33 R:R:R289 19.19 0 No Yes 8 3 0 1
L:L:Q35 R:R:P38 14.21 0 No No 4 7 0 1
L:L:Q35 R:R:E40 3.82 0 No No 4 4 0 1
L:L:K38 R:R:A36 3.21 0 No No 4 5 0 1
L:L:Y40 R:R:L34 12.89 0 Yes No 4 2 0 1
L:L:H45 R:R:T28 6.85 0 No No 6 7 0 1
L:L:F48 R:R:F32 8.57 0 No No 3 3 0 1
L:L:S57 R:R:N202 5.96 0 No No 6 2 0 1
L:L:P59 R:R:V187 5.3 0 No No 7 3 0 1
L:L:D72 R:R:F32 4.78 7 Yes No 4 3 0 1
L:L:R74 R:R:F32 6.41 7 Yes No 2 3 0 1
L:L:R74 R:R:L33 4.86 7 Yes No 2 3 0 1
L:L:R74 R:R:D35 10.72 7 Yes No 2 6 0 1
L:L:E75 R:R:A37 6.03 0 No No 4 7 0 1
R:R:L29 R:R:P31 9.85 0 No No 3 5 1 2
R:R:A36 R:R:L34 4.73 0 No No 5 2 1 1
R:R:E40 R:R:N191 7.89 0 No No 4 2 1 2
R:R:K108 R:R:K48 4.31 0 Yes No 5 4 1 2
R:R:K108 R:R:V51 3.04 0 Yes No 5 5 1 2
R:R:K108 R:R:W104 4.64 0 Yes Yes 5 6 1 1
R:R:S123 R:R:W104 4.94 0 No Yes 5 6 2 1
R:R:K126 R:R:W104 9.28 0 No Yes 6 6 2 1
R:R:V187 R:R:Y197 5.05 0 No Yes 3 3 1 1
R:R:S189 R:R:V192 3.23 0 No No 1 5 1 2
R:R:R208 R:R:Y197 4.12 0 No Yes 4 3 2 1
R:R:R208 R:R:R278 4.26 0 No Yes 4 4 2 1
R:R:M209 R:R:T275 7.53 0 No No 3 4 2 2
R:R:M209 R:R:R278 7.44 0 No Yes 3 4 2 1
R:R:D274 R:R:R212 13.1 3 No No 4 5 1 2
R:R:R212 R:R:T275 6.47 3 No No 5 4 2 2
R:R:L296 R:R:V270 2.98 0 No No 5 4 1 2
R:R:D274 R:R:T275 4.34 3 No No 4 4 1 2
R:R:M277 R:R:R289 3.72 0 Yes Yes 4 3 2 1
R:R:R278 R:R:R289 8.53 3 Yes Yes 4 3 1 1
L:L:K42 R:R:L29 2.82 0 No No 3 3 0 1
L:L:H60 R:R:S189 2.79 6 Yes No 8 1 0 1
R:R:A37 R:R:P38 1.87 0 No No 7 7 1 1
R:R:S26 R:R:S27 1.63 0 No No 6 7 1 2
R:R:S189 R:R:S190 1.63 0 No No 1 2 1 2
R:R:E40 R:R:P41 1.57 0 No No 4 4 1 2
R:R:A205 R:R:R278 1.38 0 No Yes 1 4 2 1
L:L:R87 R:R:S26 1.32 0 No No 4 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6LFO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.9
Number of Linked Nodes 346
Number of Links 381
Number of Hubs 44
Number of Links mediated by Hubs 162
Number of Communities 11
Number of Nodes involved in Communities 53
Number of Links involved in Communities 63
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 174633
Length Of Smallest Path 3
Average Path Length 23.21
Length of Longest Path 46
Minimum Path Strength 1.315
Average Path Strength 6.00352
Maximum Path Strength 20.545
Minimum Path Correlation 0.7
Average Path Correlation 0.952871
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 2.85714
Average % Of Corr. Nodes 46.7331
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 36.8399
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Interleukin 8-like chemokines   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Interleukin 8-like chemokines   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinCXCL8
UniProtP10145
Sequence
>6LFO_nogp_Chain_L
AKELRCQCI KTYSKPFHP KFIKELRVI ESGPHCANT EIIVKLSDG 
RELCLDPKE NWVQRVVEK F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP25025
Sequence
>6LFO_nogp_Chain_R
SSTLPPFLL DAAPCEPES LEINKYFVV IIYALVFLL SLLGNSLVM 
LVILYSRVG RSVTDVYLL NLALADLLF ALTLPIWAA SKVNGWIFG 
TFLCKVVSL LKEVNFYSG ILLLACISV DRYLAIVHA TRTLTQKRY 
LVKFICLSI WGLSLLLAL PVLLFRRTV YSSNVSPAC YEDMGNNTA 
NWRMLLRIL PQSFGFIVP LLIMLFCYG FTLRTLFKA HMGQKHRAM 
RVIFAVVLI FLLCWLPYN LVLLADTLM RTQVIQETC ERRNHIDRA 
LDATEILGI LHSCLNPLI YAFIGQKFR HGLLKILAI H


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LFLAProteinChemokineCXCR2Homo sapiens-PubChem 153466996-3.22020-09-02doi.org/10.1038/s41586-020-2492-5
6LFMAProteinChemokineCXCR2Homo sapiensCXCL8-Gi1/β1/γ23.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFM (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL8-3.52020-09-02doi.org/10.1038/s41586-020-2492-5
6LFOAProteinChemokineCXCR2Homo sapiensCXCL8-Gi1/β1/γ23.42020-09-02doi.org/10.1038/s41586-020-2492-5
6LFO (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL8-3.42020-09-02doi.org/10.1038/s41586-020-2492-5
8XVUAProteinChemokineCXCR2Homo sapiensCXCL2--3.092025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWAAProteinChemokineCXCR2Homo sapiensCXCL1--3.482025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWFAProteinChemokineCXCR2Homo sapiensCXCL3--3.652025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWMAProteinChemokineCXCR2Homo sapiensCXCL6--3.712025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWNAProteinChemokineCXCR2Homo sapiensCXCL8--3.292025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWSAProteinChemokineCXCR2Homo sapiensCXCL5--3.062025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWVAProteinChemokineCXCR2Homo sapiensCXCL1-Go/β1/γ23.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XWV (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL1-3.072025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3AProteinChemokineCXCR2Homo sapiensCXCL3-Go/β1/γ23.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX3 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL3-3.382025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6AProteinChemokineCXCR2Homo sapiensCXCL8-Go/β1/γ22.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX6 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL8-2.992025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7AProteinChemokineCXCR2Homo sapiensCXCL5-Go/β1/γ23.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XX7 (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL5-3.322025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXHAProteinChemokineCXCR2Homo sapiensCXCL2-Go/β1/γ22.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXH (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL2-2.82025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXRAProteinChemokineCXCR2Homo sapiens--Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXR (No Gprot) AProteinChemokineCXCR2Homo sapiens--3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXXAProteinChemokineCXCR2Homo sapiensCXCL6-Go/β1/γ23.172025-01-15doi.org/10.1016/j.molcel.2025.01.024
8XXX (No Gprot) AProteinChemokineCXCR2Homo sapiensCXCL6-3.172025-01-15doi.org/10.1016/j.molcel.2025.01.024




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LFO_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.