psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A29	R:R:K108	3.21	No	Yes	0	0	5
2	L:L:K30	R:R:W104	3.48	No	Yes	0	0	6
3	L:L:K30	R:R:Y197	3.58	No	Yes	0	0	3
4	L:L:E31	R:R:D274	3.9	Yes	No	3	0	4
5	L:L:E31	R:R:R278	4.65	Yes	Yes	3	0	4
6	L:L:E31	R:R:R289	9.3	Yes	Yes	3	0	3
7	L:L:E31	R:R:L296	3.98	Yes	No	0	0	5
8	L:L:H60	L:L:L32	5.14	Yes	No	0	0	0
9	L:L:L32	R:R:Y197	16.41	No	Yes	0	0	3
10	L:L:R33	R:R:R289	19.19	No	Yes	0	0	3
11	L:L:C34	L:L:C61	7.28	No	Yes	0	0	0
12	L:L:Q35	R:R:P38	14.21	No	No	0	0	7
13	L:L:Q35	R:R:E40	3.82	No	No	0	0	4
14	L:L:C36	L:L:C77	7.28	No	No	0	0	0
15	L:L:I37	L:L:K38	8.72	No	No	0	0	0
16	L:L:K38	R:R:A36	3.21	No	No	0	0	5
17	L:L:D79	L:L:T39	4.34	No	No	0	0	0
18	L:L:K42	L:L:Y40	16.72	No	Yes	0	0	0
19	L:L:F44	L:L:Y40	4.13	No	Yes	0	0	0
20	L:L:L76	L:L:Y40	5.86	No	Yes	0	0	0
21	L:L:Y40	R:R:L34	12.89	Yes	No	0	0	2
22	L:L:K42	L:L:P43	3.35	No	No	0	0	0
23	L:L:P43	L:L:W84	12.16	No	Yes	0	0	0
24	L:L:F44	L:L:W84	12.03	No	Yes	0	0	0
25	L:L:H45	L:L:P46	4.58	No	No	0	0	0
26	L:L:H45	R:R:T28	6.85	No	No	0	0	7
27	L:L:P46	L:L:V88	8.84	No	No	0	0	0
28	L:L:K91	L:L:P46	8.36	No	No	0	0	0
29	L:L:K47	L:L:K91	5.75	No	No	0	0	0
30	L:L:F48	L:L:L70	4.87	No	No	0	0	0
31	L:L:F48	R:R:F32	8.57	No	No	0	0	3
32	L:L:I49	L:L:V68	3.07	No	No	0	0	0
33	L:L:F92	L:L:I49	6.28	No	No	0	0	0
34	L:L:E51	L:L:R53	4.65	No	No	0	0	0
35	L:L:E51	L:L:K69	5.4	No	No	0	0	0
36	L:L:F92	L:L:L52	7.31	No	No	0	0	0
37	L:L:I67	L:L:R53	5.01	No	No	0	0	0
38	L:L:E65	L:L:I55	12.3	No	No	0	0	0
39	L:L:S57	R:R:N202	5.96	No	No	0	0	2
40	L:L:G58	L:L:P59	4.06	No	No	0	0	0
41	L:L:H60	L:L:P59	3.05	Yes	No	0	0	0
42	L:L:P59	R:R:V187	5.3	No	No	0	0	3
43	L:L:C61	L:L:H60	7.37	Yes	Yes	6	0	0
44	L:L:E65	L:L:H60	3.69	No	Yes	6	0	0
45	L:L:C61	L:L:E65	9.12	Yes	No	6	0	0
46	L:L:N63	L:L:T64	5.85	No	No	8	0	0
47	L:L:N63	L:L:P80	3.26	No	Yes	8	0	0
48	L:L:P80	L:L:T64	5.25	Yes	No	8	0	0
49	L:L:I66	L:L:V68	3.07	No	No	0	0	0
50	L:L:L78	L:L:V68	2.98	No	No	0	0	0
51	L:L:D72	L:L:L70	14.93	Yes	No	0	0	0
52	L:L:D72	L:L:G73	3.35	Yes	No	0	0	0
53	L:L:D72	L:L:R74	9.53	Yes	Yes	7	0	0
54	L:L:D72	R:R:F32	4.78	Yes	No	7	0	3
55	L:L:R74	R:R:F32	6.41	Yes	No	7	0	3
56	L:L:R74	R:R:L33	4.86	Yes	No	0	0	3
57	L:L:R74	R:R:D35	10.72	Yes	No	0	0	6
58	L:L:E75	R:R:A37	6.03	No	No	0	0	7
59	L:L:D79	L:L:P80	6.44	No	Yes	0	0	0
60	L:L:D79	L:L:K81	6.91	No	No	0	0	0
61	L:L:P80	L:L:Q86	3.16	Yes	No	0	0	0
62	L:L:E82	L:L:N83	6.57	No	No	0	0	0
63	L:L:V85	L:L:W84	8.58	No	Yes	0	0	0
64	L:L:V88	L:L:W84	8.58	No	Yes	0	0	0
65	L:L:E90	L:L:Q86	3.82	No	No	0	0	0
66	L:L:E90	L:L:V89	8.56	No	No	0	0	0
67	R:R:L29	R:R:P31	9.85	No	No	0	3	5
68	R:R:P30	R:R:P31	5.84	No	No	0	3	5
69	R:R:A36	R:R:L34	4.73	No	No	0	5	2
70	R:R:C286	R:R:C39	7.28	No	No	0	6	8
71	R:R:E40	R:R:N191	7.89	No	No	0	4	2
72	R:R:N290	R:R:P41	9.77	No	No	0	3	4
73	R:R:I46	R:R:L44	5.71	No	No	0	5	2
74	R:R:E45	R:R:K48	4.05	No	No	0	4	4
75	R:R:E45	R:R:Y49	5.61	No	No	0	4	2
76	R:R:N47	R:R:V51	2.96	No	No	0	4	5
77	R:R:D297	R:R:N47	10.77	No	No	0	4	4
78	R:R:K108	R:R:K48	4.31	Yes	No	0	5	4
79	R:R:K108	R:R:V51	3.04	Yes	No	0	5	5
80	R:R:I301	R:R:V51	3.07	No	No	0	5	5
81	R:R:V109	R:R:V52	3.21	No	No	0	4	5
82	R:R:I301	R:R:I54	4.42	No	No	0	5	5
83	R:R:L101	R:R:Y55	3.52	Yes	No	4	8	7
84	R:R:A105	R:R:Y55	4	No	No	0	7	7
85	R:R:I304	R:R:Y55	4.84	No	No	4	7	7
86	R:R:L101	R:R:V58	2.98	Yes	No	4	8	7
87	R:R:I304	R:R:V58	3.07	No	No	4	7	7
88	R:R:F59	R:R:L63	6.09	No	No	0	7	5
89	R:R:F59	R:R:L101	7.31	No	Yes	0	7	8
90	R:R:F59	R:R:P102	10.11	No	No	0	7	9
91	R:R:L61	R:R:S62	3	No	No	0	5	8
92	R:R:C308	R:R:L61	4.76	No	No	0	7	5
93	R:R:S307	R:R:S62	3.26	No	No	0	8	8
94	R:R:L63	R:R:L95	4.15	No	No	0	5	7
95	R:R:D94	R:R:N66	8.08	No	No	0	9	9
96	R:R:L95	R:R:N66	4.12	No	No	0	7	9
97	R:R:N66	R:R:P311	9.77	No	No	0	9	9
98	R:R:L95	R:R:S67	6.01	No	No	0	7	3
99	R:R:F316	R:R:L68	4.87	No	No	0	6	6
100	R:R:A91	R:R:V69	3.39	No	No	0	8	8
101	R:R:A315	R:R:V69	3.39	No	No	0	7	8
102	R:R:F316	R:R:V69	3.93	No	No	0	6	8
103	R:R:F321	R:R:V72	5.24	Yes	No	0	8	7
104	R:R:L325	R:R:V72	2.98	No	No	0	6	7
105	R:R:I73	R:R:L74	4.28	No	No	0	6	2
106	R:R:I73	R:R:L88	4.28	No	No	0	6	5
107	R:R:F321	R:R:I73	3.77	Yes	No	0	8	6
108	R:R:I328	R:R:Y75	13.3	No	No	5	5	4
109	R:R:I331	R:R:Y75	3.63	No	No	5	2	4
110	R:R:H332	R:R:Y75	5.44	No	No	5	3	4
111	R:R:S76	R:R:V78	3.23	No	No	0	4	5
112	R:R:D84	R:R:G79	5.03	No	No	0	8	6
113	R:R:S81	R:R:T83	3.2	No	No	0	7	7
114	R:R:D84	R:R:S81	10.31	No	No	0	8	7
115	R:R:D143	R:R:V82	10.22	No	Yes	9	8	7
116	R:R:K158	R:R:V82	9.11	Yes	Yes	9	6	7
117	R:R:V162	R:R:V82	6.41	Yes	Yes	0	7	7
118	R:R:C139	R:R:Y86	9.41	No	Yes	0	5	7
119	R:R:I140	R:R:Y86	4.84	No	Yes	0	9	7
120	R:R:D143	R:R:Y86	8.05	No	Yes	0	8	7
121	R:R:V162	R:R:Y86	5.05	Yes	Yes	0	7	7
122	R:R:A315	R:R:L87	3.15	No	No	0	7	7
123	R:R:L88	R:R:N89	4.12	No	No	0	5	9
124	R:R:C166	R:R:N89	7.87	No	No	0	7	9
125	R:R:N89	R:R:W170	5.65	No	Yes	0	9	9
126	R:R:L136	R:R:L90	4.15	No	No	0	8	9
127	R:R:L137	R:R:L90	4.15	Yes	No	0	8	9
128	R:R:L90	R:R:N310	9.61	No	Yes	0	9	9
129	R:R:A93	R:R:N129	3.13	No	Yes	0	8	8
130	R:R:D94	R:R:S307	10.31	No	No	0	9	8
131	R:R:D94	R:R:N310	8.08	No	Yes	0	9	9
132	R:R:L125	R:R:L96	4.15	No	No	0	4	7
133	R:R:L96	R:R:N129	9.61	No	Yes	0	7	8
134	R:R:F97	R:R:K126	8.69	No	No	0	6	6
135	R:R:F97	R:R:N129	6.04	No	Yes	0	6	8
136	R:R:A98	R:R:L101	3.15	No	Yes	0	5	8
137	R:R:T100	R:R:V122	3.17	No	No	0	7	5
138	R:R:L125	R:R:T100	4.42	No	No	0	4	7
139	R:R:K126	R:R:T100	7.51	No	No	0	6	7
140	R:R:I304	R:R:L101	4.28	No	Yes	4	7	8
141	R:R:I103	R:R:P102	3.39	No	No	0	6	9
142	R:R:K108	R:R:W104	4.64	Yes	Yes	0	5	6
143	R:R:S123	R:R:W104	4.94	No	Yes	0	5	6
144	R:R:K126	R:R:W104	9.28	No	Yes	0	6	6
145	R:R:S107	R:R:W112	8.65	No	Yes	0	5	9
146	R:R:N110	R:R:V109	4.43	No	No	0	4	4
147	R:R:L118	R:R:W112	9.11	No	Yes	0	6	9
148	R:R:C119	R:R:W112	7.84	No	Yes	0	9	9
149	R:R:T186	R:R:W112	3.64	No	Yes	0	4	9
150	R:R:F114	R:R:G115	4.52	No	No	0	6	8
151	R:R:F114	R:R:L118	7.31	No	No	0	6	6
152	R:R:K120	R:R:T116	3	No	No	0	7	3
153	R:R:C119	R:R:C196	7.28	No	No	0	9	9
154	R:R:K120	R:R:L181	7.05	No	No	0	7	5
155	R:R:K120	R:R:R184	4.95	No	Yes	0	7	5
156	R:R:R184	R:R:S123	13.18	Yes	No	0	5	5
157	R:R:L124	R:R:L181	5.54	No	No	0	6	5
158	R:R:E127	R:R:F130	10.49	No	Yes	1	4	7
159	R:R:E127	R:R:Y131	13.47	No	Yes	1	4	7
160	R:R:N129	R:R:V128	4.43	Yes	Yes	0	8	5
161	R:R:S173	R:R:V128	4.85	No	Yes	0	7	5
162	R:R:L174	R:R:V128	4.47	No	Yes	0	5	5
163	R:R:F130	R:R:Y131	9.28	Yes	Yes	1	7	7
164	R:R:F130	R:R:Q216	11.71	Yes	Yes	1	7	5
165	R:R:F130	R:R:W264	11.02	Yes	Yes	1	7	8
166	R:R:S173	R:R:Y131	3.82	No	Yes	0	7	7
167	R:R:L176	R:R:Y131	12.89	No	Yes	1	4	7
168	R:R:P215	R:R:Y131	5.56	No	Yes	0	5	7
169	R:R:Q216	R:R:Y131	5.64	Yes	Yes	1	5	7
170	R:R:G219	R:R:Y131	2.9	No	Yes	0	5	7
171	R:R:S132	R:R:W170	13.59	No	Yes	0	6	9
172	R:R:S132	R:R:S173	3.26	No	No	0	6	7
173	R:R:I134	R:R:P223	3.39	Yes	No	0	8	9
174	R:R:F260	R:R:I134	7.54	Yes	Yes	1	9	8
175	R:R:I134	R:R:W264	4.7	Yes	Yes	1	8	8
176	R:R:H306	R:R:I134	3.98	Yes	Yes	1	9	8
177	R:R:L135	R:R:L172	4.15	No	No	0	6	4
178	R:R:C139	R:R:L136	3.17	No	No	0	5	8
179	R:R:F260	R:R:L137	3.65	Yes	Yes	0	9	8
180	R:R:H306	R:R:L137	3.86	Yes	Yes	0	9	8
181	R:R:L137	R:R:Y314	11.72	Yes	Yes	0	8	9
182	R:R:A138	R:R:P223	3.74	No	No	0	7	9
183	R:R:I140	R:R:R144	5.01	No	No	0	9	9
184	R:R:M227	R:R:S141	6.13	No	No	0	8	9
185	R:R:C230	R:R:S141	3.44	No	No	2	7	9
186	R:R:S141	R:R:Y231	6.36	No	Yes	2	9	9
187	R:R:D143	R:R:K158	6.91	No	Yes	9	8	6
188	R:R:R144	R:R:Y231	10.29	No	Yes	0	9	9
189	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
190	R:R:V149	R:R:Y145	11.36	No	Yes	2	7	8
191	R:R:H150	R:R:Y145	6.53	No	Yes	2	6	8
192	R:R:C230	R:R:Y145	4.03	No	Yes	2	7	8
193	R:R:F233	R:R:Y145	6.19	No	Yes	0	4	8
194	R:R:L146	R:R:T154	2.95	No	Yes	0	5	5
195	R:R:A147	R:R:K158	4.82	No	Yes	0	8	6
196	R:R:I148	R:R:T234	3.04	No	No	0	8	8
197	R:R:H150	R:R:V149	4.15	No	No	2	6	7
198	R:R:T237	R:R:V149	7.93	No	No	0	5	7
199	R:R:H150	R:R:T154	9.58	No	Yes	0	6	5
200	R:R:R153	R:R:T152	11.64	No	No	0	5	5
201	R:R:I165	R:R:L161	4.28	No	No	0	5	4
202	R:R:K163	R:R:V162	4.55	No	Yes	0	4	7
203	R:R:I165	R:R:S168	3.1	No	No	0	5	2
204	R:R:L172	R:R:L176	4.15	No	No	1	4	4
205	R:R:F218	R:R:L172	3.65	Yes	No	1	4	4
206	R:R:F218	R:R:L176	4.87	Yes	No	1	4	4
207	R:R:L211	R:R:P179	6.57	No	No	0	4	8
208	R:R:R184	R:R:V180	3.92	Yes	No	0	5	4
209	R:R:F183	R:R:L182	8.53	No	No	0	5	4
210	R:R:D199	R:R:F183	10.75	Yes	No	0	4	5
211	R:R:C196	R:R:R184	5.57	No	Yes	10	9	5
212	R:R:E198	R:R:R184	27.91	No	Yes	10	5	5
213	R:R:M200	R:R:R185	6.2	No	No	0	5	4
214	R:R:T186	R:R:Y188	6.24	No	No	0	4	1
215	R:R:V187	R:R:Y197	5.05	No	Yes	0	3	3
216	R:R:P194	R:R:Y188	8.34	No	No	0	5	1
217	R:R:S189	R:R:V192	3.23	No	No	0	1	5
218	R:R:C196	R:R:E198	3.04	No	No	10	9	5
219	R:R:R208	R:R:Y197	4.12	No	Yes	0	4	3
220	R:R:D199	R:R:W207	3.35	Yes	No	0	4	3
221	R:R:N203	R:R:N206	5.45	No	No	0	4	1
222	R:R:N203	R:R:W207	6.78	No	No	0	4	3
223	R:R:R208	R:R:R278	4.26	No	Yes	0	4	4
224	R:R:M209	R:R:T275	7.53	No	No	0	3	4
225	R:R:M209	R:R:R278	7.44	No	Yes	0	3	4
226	R:R:L271	R:R:R212	10.93	No	No	0	6	5
227	R:R:D274	R:R:R212	13.1	No	No	3	4	5
228	R:R:R212	R:R:T275	6.47	No	No	3	5	4
229	R:R:L214	R:R:P215	4.93	No	No	0	3	5
230	R:R:N268	R:R:Q216	6.6	No	Yes	0	8	5
231	R:R:L271	R:R:Q216	5.32	No	Yes	0	6	5
232	R:R:I221	R:R:S217	3.1	No	No	0	4	4
233	R:R:F218	R:R:V222	5.24	Yes	No	0	4	5
234	R:R:F220	R:R:N268	16.92	No	No	0	8	8
235	R:R:P223	R:R:V222	3.53	No	No	0	9	5
236	R:R:L224	R:R:L261	5.54	No	No	0	7	6
237	R:R:F229	R:R:L225	7.31	No	No	0	4	3
238	R:R:F260	R:R:M227	6.22	Yes	No	0	9	8
239	R:R:L228	R:R:V257	2.98	No	No	0	4	7
240	R:R:C230	R:R:Y231	5.38	No	Yes	2	7	9
241	R:R:I253	R:R:Y231	6.04	No	Yes	0	7	9
242	R:R:V256	R:R:Y231	5.05	Yes	Yes	2	8	9
243	R:R:I253	R:R:L235	12.85	No	No	0	7	4
244	R:R:F254	R:R:L235	7.31	No	No	0	4	4
245	R:R:F239	R:R:M250	3.73	No	No	0	5	5
246	R:R:A241	R:R:M243	3.22	No	Yes	0	3	4
247	R:R:K246	R:R:M243	5.76	No	Yes	11	7	4
248	R:R:H247	R:R:R251	4.51	No	No	0	5	5
249	R:R:I317	R:R:R248	3.76	No	No	0	6	7
250	R:R:F254	R:R:M250	3.73	No	No	0	4	5
251	R:R:I317	R:R:V252	3.07	No	No	0	6	7
252	R:R:I313	R:R:V256	3.07	Yes	Yes	2	7	8
253	R:R:V256	R:R:Y314	7.57	Yes	Yes	2	8	9
254	R:R:L261	R:R:V257	2.98	No	No	0	6	7
255	R:R:I259	R:R:L309	4.28	No	No	0	6	6
256	R:R:I259	R:R:I313	2.94	No	Yes	0	6	7
257	R:R:F260	R:R:W264	7.02	Yes	Yes	1	9	8
258	R:R:L261	R:R:L265	4.15	No	No	0	6	6
259	R:R:C263	R:R:W264	3.92	No	Yes	1	7	8
260	R:R:C263	R:R:H306	7.37	No	Yes	1	7	9
261	R:R:W264	R:R:Y267	6.75	Yes	Yes	0	8	7
262	R:R:G303	R:R:W264	5.63	No	Yes	0	7	8
263	R:R:H306	R:R:W264	16.93	Yes	Yes	1	9	8
264	R:R:L265	R:R:P266	3.28	No	No	0	6	9
265	R:R:P266	R:R:T299	3.5	No	No	0	9	6
266	R:R:L302	R:R:P266	3.28	No	No	0	7	9
267	R:R:N268	R:R:Y267	5.81	No	Yes	0	8	7
268	R:R:L271	R:R:Y267	3.52	No	Yes	0	6	7
269	R:R:T299	R:R:Y267	7.49	No	Yes	0	6	7
270	R:R:E300	R:R:Y267	17.96	No	Yes	0	5	7
271	R:R:L296	R:R:V270	2.98	No	No	0	5	4
272	R:R:T299	R:R:V270	3.17	No	No	0	6	4
273	R:R:D274	R:R:T275	4.34	No	No	3	4	4
274	R:R:L276	R:R:V281	5.96	No	No	0	4	4
275	R:R:I282	R:R:M277	4.37	No	Yes	0	5	4
276	R:R:M277	R:R:R289	3.72	Yes	Yes	0	4	3
277	R:R:R278	R:R:R289	8.53	Yes	Yes	3	4	3
278	R:R:L302	R:R:L305	4.15	No	No	0	7	5
279	R:R:C308	R:R:L309	4.76	No	No	0	7	6
280	R:R:L309	R:R:L312	5.54	No	No	0	6	6
281	R:R:N310	R:R:P311	4.89	Yes	No	0	9	9
282	R:R:N310	R:R:Y314	6.98	Yes	Yes	0	9	9
283	R:R:I313	R:R:Y314	6.04	Yes	Yes	2	7	9
284	R:R:A315	R:R:F321	4.16	No	Yes	0	7	8
285	R:R:H323	R:R:Q319	11.13	No	No	0	4	5
286	R:R:F321	R:R:K320	3.72	Yes	No	0	8	6
287	R:R:I328	R:R:K327	5.82	No	No	0	5	4
288	R:R:I328	R:R:I331	2.94	No	No	5	5	2
289	R:R:H332	R:R:I331	6.63	No	No	5	3	2
290	R:R:D199	R:R:T204	2.89	Yes	No	0	4	3
291	L:L:E82	L:L:V85	2.85	No	No	0	0	0
292	R:R:I113	R:R:L118	2.85	No	No	0	3	6
293	R:R:I169	R:R:L135	2.85	No	No	0	6	6
294	R:R:I169	R:R:L136	2.85	No	No	0	6	8
295	R:R:I148	R:R:L238	2.85	No	No	0	8	8
296	R:R:I282	R:R:L276	2.85	No	No	0	5	4
297	R:R:L71	R:R:M70	2.83	No	No	0	3	6
298	R:R:Q157	R:R:T154	2.83	No	Yes	0	7	5
299	L:L:K42	R:R:L29	2.82	No	No	0	0	3
300	L:L:K50	L:L:L70	2.82	No	No	0	0	0
301	L:L:H60	R:R:S189	2.79	Yes	No	0	0	1
302	L:L:L76	L:L:L78	2.77	No	No	0	0	0
303	R:R:L57	R:R:L61	2.77	No	No	0	5	5
304	R:R:L265	R:R:L269	2.77	No	No	0	6	6
305	L:L:E56	L:L:I55	2.73	No	No	0	0	0
306	L:L:E75	L:L:I67	2.73	No	No	0	0	0
307	R:R:E284	R:R:M277	2.71	No	Yes	0	3	4
308	R:R:D293	R:R:N290	2.69	No	No	0	4	3
309	R:R:R80	R:R:V85	2.62	No	No	0	7	6
310	R:R:R185	R:R:T116	2.59	No	No	0	4	3
311	R:R:R236	R:R:T237	2.59	No	No	0	4	5
312	R:R:R288	R:R:T285	2.59	No	No	0	1	5
313	L:L:F48	L:L:I49	2.51	No	No	0	0	0
314	L:L:I55	L:L:R53	2.51	No	No	0	0	0
315	R:R:F50	R:R:I53	2.51	No	No	0	5	5
316	R:R:T234	R:R:Y145	2.5	No	Yes	0	8	8
317	R:R:K158	R:R:R159	2.48	Yes	No	0	6	3
318	R:R:F183	R:R:L211	2.44	No	No	0	5	4
319	R:R:I165	R:R:Y86	2.42	No	Yes	0	5	7
320	R:R:D199	R:R:R208	2.38	Yes	No	0	4	4
321	R:R:Q245	R:R:R248	2.34	No	No	0	4	7
322	R:R:Q319	R:R:R322	2.34	No	No	0	5	8
323	R:R:L92	R:R:W170	2.28	No	Yes	0	6	9
324	R:R:C39	R:R:P41	1.88	No	No	0	8	4
325	R:R:A37	R:R:P38	1.87	No	No	0	7	7
326	R:R:G111	R:R:S107	1.86	No	No	0	4	5
327	R:R:G111	R:R:S193	1.86	No	No	0	4	3
328	R:R:G133	R:R:S132	1.86	No	No	0	9	6
329	R:R:G201	R:R:T204	1.82	No	No	0	4	3
330	R:R:G318	R:R:I317	1.76	No	No	0	7	6
331	R:R:G244	R:R:M243	1.75	No	Yes	0	4	4
332	R:R:G324	R:R:K320	1.74	No	No	0	5	6
333	R:R:G324	R:R:K327	1.74	No	No	0	5	4
334	L:L:C61	L:L:S57	1.72	Yes	No	0	0	0
335	R:R:G65	R:R:L64	1.71	No	No	0	7	4
336	R:R:G65	R:R:L68	1.71	No	No	0	7	6
337	R:R:A177	R:R:V128	1.7	No	Yes	0	7	5
338	R:R:A295	R:R:V270	1.7	No	No	0	5	4
339	L:L:C36	L:L:T39	1.69	No	No	0	0	0
340	L:L:C77	L:L:I67	1.64	No	No	0	0	0
341	R:R:L178	R:R:P179	1.64	No	No	0	3	8
342	R:R:S26	R:R:S27	1.63	No	No	0	6	7
343	R:R:S189	R:R:S190	1.63	No	No	0	1	2
344	R:R:A138	R:R:I226	1.62	No	No	0	7	6
345	R:R:A255	R:R:I313	1.62	No	Yes	0	5	7
346	R:R:A273	R:R:I292	1.62	No	No	0	5	5
347	R:R:V162	R:R:V85	1.6	Yes	No	0	7	6
348	R:R:V121	R:R:V122	1.6	No	No	0	5	5
349	R:R:V252	R:R:V256	1.6	No	Yes	0	7	8
350	R:R:T83	R:R:V82	1.59	No	Yes	0	7	7
351	R:R:C263	R:R:L262	1.59	No	No	0	7	5
352	R:R:T279	R:R:V281	1.59	No	No	0	1	4
353	R:R:E40	R:R:P41	1.57	No	No	0	4	4
354	L:L:I66	L:L:V54	1.54	No	No	0	0	0
355	L:L:I66	L:L:V89	1.54	No	No	0	0	0
356	R:R:I53	R:R:V52	1.54	No	No	0	5	5
357	R:R:A298	R:R:D297	1.54	No	No	0	5	4
358	R:R:M70	R:R:S67	1.53	No	No	0	6	3
359	R:R:K327	R:R:S76	1.53	No	No	0	4	4
360	R:R:C286	R:R:E287	1.52	No	No	0	6	4
361	R:R:L258	R:R:V257	1.49	No	No	0	5	7
362	R:R:I53	R:R:I54	1.47	No	No	0	5	5
363	R:R:L155	R:R:T156	1.47	No	No	0	4	2
364	R:R:I292	R:R:M277	1.46	No	Yes	0	5	4
365	L:L:E82	L:L:S41	1.44	No	No	0	0	0
366	R:R:Q280	R:R:T279	1.42	No	No	0	2	1
367	R:R:G171	R:R:W170	1.41	No	Yes	0	4	9
368	R:R:L238	R:R:M243	1.41	No	Yes	11	8	4
369	R:R:K246	R:R:L238	1.41	No	No	11	7	8
370	R:R:E287	R:R:T285	1.41	No	No	0	4	5
371	R:R:A205	R:R:R278	1.38	No	Yes	0	1	4
372	R:R:E42	R:R:K48	1.35	No	No	0	4	4
373	L:L:R87	R:R:S26	1.32	No	No	0	0	6
374	R:R:F218	R:R:S217	1.32	Yes	No	0	4	4
375	L:L:R87	L:L:V88	1.31	No	No	0	0	0
376	R:R:F117	R:R:V121	1.31	No	No	0	1	5
377	R:R:R153	R:R:T154	1.29	No	Yes	0	5	5
378	R:R:E284	R:R:Q283	1.27	No	No	0	3	2
379	R:R:F164	R:R:L161	1.22	No	No	0	3	4
380	R:R:N47	R:R:R294	1.21	No	No	0	4	2
381	R:R:R248	R:R:R322	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E31	5.4575	4	3	0
2	L:L:Y40	9.9	4	0	0
3	L:L:H60	4.408	5	6	0
4	L:L:C61	6.3725	4	6	0
5	L:L:D72	8.1475	4	7	0
6	L:L:R74	7.88	4	7	0
7	L:L:P80	4.5275	4	8	0
8	L:L:W84	10.3375	4	0	0
9	R:R:V82	6.8325	4	9	7
10	R:R:Y86	5.954	5	0	7
11	R:R:L101	4.248	5	4	8
12	R:R:W104	5.585	4	0	6
13	R:R:K108	3.8	4	0	5
14	R:R:W112	7.31	4	0	9
15	R:R:V128	3.8625	4	0	5
16	R:R:N129	5.8025	4	0	8
17	R:R:F130	10.625	4	1	7
18	R:R:Y131	7.65143	7	1	7
19	R:R:I134	4.9025	4	1	8
20	R:R:L137	5.845	4	0	8
21	R:R:Y145	5.68833	6	2	8
22	R:R:T154	4.1625	4	0	5
23	R:R:K158	5.83	4	9	6
24	R:R:V162	4.4025	4	0	7
25	R:R:W170	5.7325	4	0	9
26	R:R:R184	11.106	5	10	5
27	R:R:Y197	7.29	4	0	3
28	R:R:D199	4.8425	4	0	4
29	R:R:Q216	7.3175	4	1	5
30	R:R:F218	3.77	4	1	4
31	R:R:Y231	6.624	5	2	9
32	R:R:M243	3.035	4	11	4
33	R:R:V256	4.3225	4	2	8
34	R:R:F260	6.1075	4	1	9
35	R:R:W264	7.99571	7	1	8
36	R:R:Y267	8.306	5	0	7
37	R:R:M277	3.065	4	0	4
38	R:R:R278	5.252	5	3	4
39	R:R:R289	10.185	4	3	3
40	R:R:H306	8.035	4	1	9
41	R:R:N310	7.39	4	0	9
42	R:R:I313	3.4175	4	2	7
43	R:R:Y314	8.0775	4	2	9
44	R:R:F321	4.2225	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K30	R:R:W104	12.1261	3.48	No	Yes	0	0	6
2	L:L:K30	R:R:Y197	12.5962	3.58	No	Yes	0	0	3
3	R:R:R208	R:R:Y197	85.343	4.12	No	Yes	0	4	3
4	R:R:R208	R:R:R278	94.8749	4.26	No	Yes	0	4	4
5	L:L:E31	R:R:R278	62.8742	4.65	Yes	Yes	3	0	4
6	L:L:E31	R:R:D274	36.0745	3.9	Yes	No	3	0	4
7	L:L:E31	R:R:L296	34.921	3.98	Yes	No	0	0	5
8	L:L:L32	R:R:Y197	86.4342	16.41	No	Yes	0	0	3
9	L:L:H60	L:L:L32	85.4997	5.14	Yes	No	0	0	0
10	L:L:E65	L:L:H60	77.8699	3.69	No	Yes	6	0	0
11	L:L:E65	L:L:I55	77.2284	12.3	No	No	0	0	0
12	L:L:I55	L:L:R53	75.3108	2.51	No	No	0	0	0
13	L:L:I67	L:L:R53	72.4197	5.01	No	No	0	0	0
14	L:L:E75	L:L:I67	15.2489	2.73	No	No	0	0	0
15	L:L:E75	R:R:A37	14.1722	6.03	No	No	0	0	7
16	R:R:A37	R:R:P38	13.0937	1.87	No	No	0	7	7
17	L:L:Q35	R:R:P38	12.0132	14.21	No	No	0	0	7
18	L:L:Q35	R:R:E40	10.9307	3.82	No	No	0	0	4
19	L:L:C77	L:L:I67	57.7013	1.64	No	No	0	0	0
20	L:L:C36	L:L:C77	56.7045	7.28	No	No	0	0	0
21	L:L:C36	L:L:T39	55.7009	1.69	No	No	0	0	0
22	L:L:D79	L:L:T39	54.7002	4.34	No	No	0	0	0
23	L:L:D79	L:L:P80	52.693	6.44	No	Yes	0	0	0
24	L:L:P80	L:L:Q86	49.6656	3.16	Yes	No	0	0	0
25	L:L:E90	L:L:Q86	48.6533	3.82	No	No	0	0	0
26	L:L:E90	L:L:V89	47.6389	8.56	No	No	0	0	0
27	L:L:I66	L:L:V89	46.6197	1.54	No	No	0	0	0
28	L:L:I66	L:L:V68	44.5843	3.07	No	No	0	0	0
29	L:L:L78	L:L:V68	29.0619	2.98	No	No	0	0	0
30	L:L:L76	L:L:L78	28.0116	2.77	No	No	0	0	0
31	L:L:L76	L:L:Y40	26.9583	5.86	No	Yes	0	0	0
32	L:L:F44	L:L:Y40	16.2505	4.13	No	Yes	0	0	0
33	L:L:F44	L:L:W84	15.1817	12.03	No	Yes	0	0	0
34	L:L:I49	L:L:V68	15.2323	3.07	No	No	0	0	0
35	L:L:F48	L:L:I49	11.9966	2.51	No	No	0	0	0
36	R:R:K126	R:R:W104	19.7306	9.28	No	Yes	0	6	6
37	R:R:F97	R:R:K126	20.2815	8.69	No	No	0	6	6
38	R:R:F97	R:R:N129	20.4704	6.04	No	Yes	0	6	8
39	R:R:N129	R:R:V128	22.7832	4.43	Yes	Yes	0	8	5
40	R:R:S173	R:R:V128	23.4257	4.85	No	Yes	0	7	5
41	R:R:S173	R:R:Y131	29.9954	3.82	No	Yes	0	7	7
42	R:R:F130	R:R:Y131	22.7774	9.28	Yes	Yes	1	7	7
43	R:R:F130	R:R:W264	23.5289	11.02	Yes	Yes	1	7	8
44	R:R:F260	R:R:W264	66.5693	7.02	Yes	Yes	1	9	8
45	R:R:F260	R:R:L137	52.0797	3.65	Yes	Yes	0	9	8
46	R:R:L137	R:R:L90	53.1388	4.15	Yes	No	0	8	9
47	R:R:L90	R:R:N310	35.3191	9.61	No	Yes	0	9	9
48	R:R:D94	R:R:N310	38.1129	8.08	No	Yes	0	9	9
49	R:R:D94	R:R:N66	28.7699	8.08	No	No	0	9	9
50	R:R:L95	R:R:N66	53.6119	4.12	No	No	0	7	9
51	R:R:L63	R:R:L95	38.3329	4.15	No	No	0	5	7
52	R:R:F59	R:R:L63	34.5083	6.09	No	No	0	7	5
53	R:R:F59	R:R:L101	23.0227	7.31	No	Yes	0	7	8
54	R:R:H306	R:R:W264	51.6018	16.93	Yes	Yes	1	9	8
55	R:R:H306	R:R:L137	52.1547	3.86	Yes	Yes	0	9	8
56	R:R:L137	R:R:Y314	50.7199	11.72	Yes	Yes	0	8	9
57	R:R:N310	R:R:Y314	35.691	6.98	Yes	Yes	0	9	9
58	R:R:N310	R:R:P311	30.5639	4.89	Yes	No	0	9	9
59	R:R:N66	R:R:P311	28.6677	9.77	No	No	0	9	9
60	R:R:L95	R:R:S67	11.5196	6.01	No	No	0	7	3
61	R:R:S132	R:R:S173	16.1065	3.26	No	No	0	6	7
62	R:R:S132	R:R:W170	15.1233	13.59	No	Yes	0	6	9
63	R:R:N89	R:R:W170	13.6339	5.65	No	Yes	0	9	9
64	R:R:L88	R:R:N89	12.6313	4.12	No	No	0	5	9
65	R:R:I73	R:R:L88	12.1271	4.28	No	No	0	6	5
66	R:R:F321	R:R:I73	11.1127	3.77	Yes	No	0	8	6
67	R:R:C139	R:R:L136	20.9697	3.17	No	No	0	5	8
68	R:R:C139	R:R:Y86	20.1365	9.41	No	Yes	0	5	7
69	R:R:F260	R:R:M227	15.5545	6.22	Yes	No	0	9	8
70	R:R:M227	R:R:S141	15.0756	6.13	No	No	0	8	9
71	R:R:S123	R:R:W104	11.0368	4.94	No	Yes	0	5	6
72	R:R:R184	R:R:S123	10.5783	13.18	Yes	No	0	5	5
73	R:R:C230	R:R:S141	10.8801	3.44	No	No	2	7	9
74	R:R:C230	R:R:Y145	12.5271	4.03	No	Yes	2	7	8
75	R:R:D199	R:R:R208	12.5593	2.38	Yes	No	0	4	4
76	R:R:M209	R:R:R278	31.8537	7.44	No	Yes	0	3	4
77	R:R:M209	R:R:T275	32.0221	7.53	No	No	0	3	4
78	R:R:D274	R:R:R212	36.2313	13.1	No	No	3	4	5
79	R:R:L271	R:R:R212	68.4841	10.93	No	No	0	6	5
80	R:R:R212	R:R:T275	32.2071	6.47	No	No	3	5	4
81	R:R:L296	R:R:V270	35.1439	2.98	No	No	0	5	4
82	R:R:T299	R:R:V270	35.7027	3.17	No	No	0	6	4
83	R:R:V256	R:R:Y314	10.1704	7.57	Yes	Yes	2	8	9
84	R:R:L271	R:R:Y267	64.0092	3.52	No	Yes	0	6	7
85	R:R:T299	R:R:Y267	39.0007	7.49	No	Yes	0	6	7
86	R:R:W264	R:R:Y267	100	6.75	Yes	Yes	0	8	7
87	R:R:L136	R:R:L90	19.715	4.15	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:A29	R:R:K108	3.21	0	No	Yes	0	5	0	1
L:L:K30	R:R:W104	3.48	0	No	Yes	0	6	0	1
L:L:K30	R:R:Y197	3.58	0	No	Yes	0	3	0	1
L:L:E31	R:R:D274	3.9	3	Yes	No	0	4	0	1
L:L:E31	R:R:R278	4.65	3	Yes	Yes	0	4	0	1
L:L:E31	R:R:R289	9.3	3	Yes	Yes	0	3	0	1
L:L:E31	R:R:L296	3.98	3	Yes	No	0	5	0	1
L:L:L32	R:R:Y197	16.41	0	No	Yes	0	3	0	1
L:L:R33	R:R:R289	19.19	0	No	Yes	0	3	0	1
L:L:Q35	R:R:P38	14.21	0	No	No	0	7	0	1
L:L:Q35	R:R:E40	3.82	0	No	No	0	4	0	1
L:L:K38	R:R:A36	3.21	0	No	No	0	5	0	1
L:L:Y40	R:R:L34	12.89	0	Yes	No	0	2	0	1
L:L:H45	R:R:T28	6.85	0	No	No	0	7	0	1
L:L:F48	R:R:F32	8.57	0	No	No	0	3	0	1
L:L:S57	R:R:N202	5.96	0	No	No	0	2	0	1
L:L:P59	R:R:V187	5.3	0	No	No	0	3	0	1
L:L:D72	R:R:F32	4.78	7	Yes	No	0	3	0	1
L:L:R74	R:R:F32	6.41	7	Yes	No	0	3	0	1
L:L:R74	R:R:L33	4.86	7	Yes	No	0	3	0	1
L:L:R74	R:R:D35	10.72	7	Yes	No	0	6	0	1
L:L:E75	R:R:A37	6.03	0	No	No	0	7	0	1
R:R:L29	R:R:P31	9.85	0	No	No	3	5	1	2
R:R:A36	R:R:L34	4.73	0	No	No	5	2	1	1
R:R:E40	R:R:N191	7.89	0	No	No	4	2	1	2
R:R:K108	R:R:K48	4.31	0	Yes	No	5	4	1	2
R:R:K108	R:R:V51	3.04	0	Yes	No	5	5	1	2
R:R:K108	R:R:W104	4.64	0	Yes	Yes	5	6	1	1
R:R:S123	R:R:W104	4.94	0	No	Yes	5	6	2	1
R:R:K126	R:R:W104	9.28	0	No	Yes	6	6	2	1
R:R:V187	R:R:Y197	5.05	0	No	Yes	3	3	1	1
R:R:S189	R:R:V192	3.23	0	No	No	1	5	1	2
R:R:R208	R:R:Y197	4.12	0	No	Yes	4	3	2	1
R:R:R208	R:R:R278	4.26	0	No	Yes	4	4	2	1
R:R:M209	R:R:T275	7.53	0	No	No	3	4	2	2
R:R:M209	R:R:R278	7.44	0	No	Yes	3	4	2	1
R:R:D274	R:R:R212	13.1	3	No	No	4	5	1	2
R:R:R212	R:R:T275	6.47	3	No	No	5	4	2	2
R:R:L296	R:R:V270	2.98	0	No	No	5	4	1	2
R:R:D274	R:R:T275	4.34	3	No	No	4	4	1	2
R:R:M277	R:R:R289	3.72	0	Yes	Yes	4	3	2	1
R:R:R278	R:R:R289	8.53	3	Yes	Yes	4	3	1	1
L:L:K42	R:R:L29	2.82	0	No	No	0	3	0	1
L:L:H60	R:R:S189	2.79	6	Yes	No	0	1	0	1
R:R:A37	R:R:P38	1.87	0	No	No	7	7	1	1
R:R:S26	R:R:S27	1.63	0	No	No	6	7	1	2
R:R:S189	R:R:S190	1.63	0	No	No	1	2	1	2
R:R:E40	R:R:P41	1.57	0	No	No	4	4	1	2
R:R:A205	R:R:R278	1.38	0	No	Yes	1	4	2	1
L:L:R87	R:R:S26	1.32	0	No	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6LFO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.9
Number of Linked Nodes	346
Number of Links	381
Number of Hubs	44
Number of Links mediated by Hubs	162
Number of Communities	11
Number of Nodes involved in Communities	53
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	174633
Length Of Smallest Path	3
Average Path Length	23.21
Length of Longest Path	46
Minimum Path Strength	1.315
Average Path Strength	6.00352
Maximum Path Strength	20.545
Minimum Path Correlation	0.7
Average Path Correlation	0.952871
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	46.7331
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.8399
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular function activator activity • signaling receptor binding • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CXCR chemokine receptor binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • interleukin-8 receptor binding • cell adhesion • regulation of cell adhesion • positive chemotaxis • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • response to external stimulus • induction of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • developmental process • multicellular organismal process • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • multicellular organism development • tube morphogenesis • anatomical structure formation involved in morphogenesis • anatomical structure development • blood vessel development • system development • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • digestive system development • animal organ development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • neutrophil activation • immune system process • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • neutrophil chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • biological process involved in interspecies interaction between organisms • entry of bacterium into host cell • regulation of entry of bacterium into host cell • symbiont entry into host • modulation by symbiont of entry into host • biological process involved in interaction with host • biological process involved in symbiotic interaction • regulation of biological process involved in symbiotic interaction • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • regulation of cell motility • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of immune system process • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of granulocyte chemotaxis • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • response to fibroblast growth factor • cellular response to growth factor stimulus • response to growth factor • cellular response to fibroblast growth factor stimulus • regulation of cell adhesion molecule production • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell adhesion molecule production • cell adhesion molecule production • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • humoral immune response • defense response • immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • inflammatory response • regulation of signaling • negative regulation of signaling • negative regulation of response to stimulus • regulation of signal transduction • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • regulation of single stranded viral RNA replication via double stranded DNA intermediate • RNA metabolic process • viral life cycle • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • regulation of RNA metabolic process • viral RNA genome replication • viral process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • primary metabolic process • nucleobase-containing compound biosynthetic process • single stranded viral RNA replication via double stranded DNA intermediate • nucleic acid metabolic process • regulation of viral life cycle • regulation of viral process • viral genome replication • regulation of viral genome replication • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • cellular response to interleukin-1 • response to interleukin-1 • cellular response to stress • response to endoplasmic reticulum stress • G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • positive regulation of cell population proliferation • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular defense response • cytokine-mediated signaling pathway • cellular response to interleukin-8 • response to interleukin-8 • interleukin-8-mediated signaling pathway • cell surface • external side of plasma membrane • mast cell granule • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • D2 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleolus • cell cortex • centrosome • microtubule organizing center • centriolar satellite • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>6LFO_nogp_Chain_R S S T L P P F L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A I H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LFO_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.