psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S2	R:R:S43	6.52	No	No	0	0	5
2	L:L:V3	R:R:G111	3.68	No	No	0	0	4
3	L:L:V3	R:R:S193	3.23	No	No	0	0	3
4	L:L:E6	L:L:T5	2.82	Yes	No	0	0	0
5	L:L:E6	L:L:R8	4.65	Yes	Yes	2	0	0
6	L:L:E6	R:R:R208	10.47	Yes	No	0	0	4
7	L:L:E6	R:R:R212	3.49	Yes	Yes	2	0	5
8	L:L:E6	R:R:D274	6.5	Yes	Yes	2	0	4
9	L:L:E6	R:R:R278	6.98	Yes	Yes	2	0	4
10	L:L:H34	L:L:L7	3.86	Yes	No	0	0	0
11	L:L:L7	R:R:Y197	19.93	No	No	0	0	3
12	L:L:R8	R:R:D274	8.34	Yes	Yes	2	0	4
13	L:L:R8	R:R:R278	17.06	Yes	Yes	2	0	4
14	L:L:R8	R:R:R289	10.66	Yes	Yes	2	0	3
15	L:L:R8	R:R:D293	5.96	Yes	No	0	0	4
16	L:L:C35	L:L:C9	7.28	No	No	7	0	0
17	L:L:C9	L:L:E39	9.12	No	Yes	7	0	0
18	L:L:K29	L:L:Q10	4.07	Yes	Yes	0	0	0
19	L:L:E39	L:L:Q10	3.82	Yes	Yes	0	0	0
20	L:L:Q10	R:R:N191	10.56	Yes	No	0	0	2
21	L:L:C11	L:L:E39	4.56	No	Yes	0	0	0
22	L:L:C11	L:L:C51	5.46	No	No	0	0	0
23	L:L:L12	L:L:Q13	6.65	No	No	0	0	0
24	L:L:L12	R:R:E284	3.98	No	Yes	2	0	3
25	L:L:L12	R:R:R289	3.64	No	Yes	2	0	3
26	L:L:N53	L:L:T14	2.92	Yes	No	0	0	0
27	L:L:L15	R:R:A36	4.73	No	No	0	0	5
28	L:L:I18	L:L:I23	8.83	No	No	0	0	0
29	L:L:I18	L:L:L44	2.85	No	Yes	0	0	0
30	L:L:I18	L:L:L52	4.28	No	Yes	0	0	0
31	L:L:H19	L:L:P20	7.63	No	No	0	0	0
32	L:L:H19	L:L:K21	5.24	No	No	0	0	0
33	L:L:I62	L:L:P20	3.39	No	No	9	0	0
34	L:L:M66	L:L:P20	3.35	No	No	9	0	0
35	L:L:L44	L:L:N22	9.61	Yes	No	0	0	0
36	L:L:S25	L:L:T43	4.8	No	No	0	0	0
37	L:L:S25	N:N:N27	2.98	No	No	0	0	0
38	L:L:I63	L:L:V26	3.07	No	No	0	0	0
39	L:L:K29	L:L:N27	4.2	Yes	No	1	0	0
40	L:L:N27	N:N:S25	2.98	No	No	1	0	0
41	L:L:N27	N:N:N27	12.26	No	No	0	0	0
42	L:L:V28	L:L:V40	6.41	No	No	0	0	0
43	L:L:H34	L:L:K29	5.24	Yes	Yes	1	0	0
44	L:L:K29	N:N:S25	3.06	Yes	No	1	0	0
45	L:L:P31	L:L:S30	3.56	No	No	0	0	0
46	L:L:S30	N:N:M66	4.6	No	No	0	0	0
47	L:L:P31	L:L:T38	6.99	No	No	0	0	0
48	L:L:P31	N:N:S69	7.13	No	No	0	0	0
49	L:L:G32	L:L:P33	4.06	No	Yes	0	0	0
50	L:L:H34	L:L:P33	4.58	Yes	Yes	1	0	0
51	L:L:P33	N:N:Q24	3.16	Yes	No	1	0	0
52	L:L:P33	R:R:R185	2.88	Yes	No	1	0	4
53	L:L:P33	R:R:V187	3.53	Yes	No	1	0	3
54	L:L:P33	R:R:D199	11.27	Yes	No	1	0	4
55	L:L:H34	N:N:Q24	3.71	Yes	No	1	0	0
56	L:L:C35	L:L:E39	9.12	No	Yes	7	0	0
57	L:L:P54	L:L:T38	5.25	No	No	0	0	0
58	L:L:L52	L:L:V40	4.47	Yes	No	0	0	0
59	L:L:A42	L:L:L52	3.15	No	Yes	0	0	0
60	L:L:L44	L:L:N46	6.87	Yes	No	8	0	0
61	L:L:L44	L:L:R48	3.64	Yes	No	8	0	0
62	L:L:N46	L:L:R48	3.62	No	No	8	0	0
63	L:L:A50	L:L:R48	4.15	No	No	0	0	0
64	L:L:K49	R:R:P38	3.35	No	No	0	0	7
65	L:L:K49	R:R:E40	5.4	No	No	0	0	4
66	L:L:L52	L:L:V59	8.94	Yes	No	0	0	0
67	L:L:N53	L:L:P54	6.52	Yes	No	0	0	0
68	L:L:A55	L:L:N53	4.69	No	Yes	0	0	0
69	L:L:N53	L:L:S56	4.47	Yes	Yes	0	0	0
70	L:L:P57	L:L:S56	3.56	No	Yes	0	0	0
71	L:L:I58	L:L:S56	4.64	No	Yes	0	0	0
72	L:L:S56	L:L:V59	4.85	Yes	No	0	0	0
73	L:L:I58	L:L:I62	2.94	No	No	0	0	0
74	L:L:I63	L:L:V59	3.07	No	No	0	0	0
75	L:L:E64	L:L:K60	4.05	No	Yes	0	0	0
76	L:L:K60	N:N:E64	10.8	Yes	No	10	0	0
77	L:L:K60	N:N:L67	7.05	Yes	No	0	0	0
78	L:L:K60	N:N:N68	4.2	Yes	No	10	0	0
79	L:L:I62	L:L:M66	2.92	No	No	9	0	0
80	L:L:I63	L:L:L67	2.85	No	Yes	0	0	0
81	L:L:K65	L:L:M66	2.88	No	No	0	0	0
82	L:L:L67	N:N:V28	2.98	Yes	No	0	0	0
83	L:L:L67	N:N:K60	8.46	Yes	No	0	0	0
84	L:L:L67	N:N:I63	5.71	Yes	No	0	0	0
85	N:N:C35	N:N:C9	7.28	No	No	11	0	0
86	N:N:C9	N:N:E39	6.08	No	Yes	11	0	0
87	N:N:K29	N:N:Q10	4.07	No	No	0	0	0
88	N:N:C11	N:N:E39	9.12	No	Yes	0	0	0
89	N:N:C11	N:N:I41	3.27	No	No	0	0	0
90	N:N:C11	N:N:C51	7.28	No	No	0	0	0
91	N:N:N53	N:N:T14	5.85	Yes	No	0	0	0
92	N:N:L15	N:N:Q16	9.32	No	No	0	0	0
93	N:N:G17	N:N:Q16	3.29	No	No	0	0	0
94	N:N:I18	N:N:I23	7.36	Yes	No	0	0	0
95	N:N:I18	N:N:L44	4.28	Yes	No	0	0	0
96	N:N:I18	N:N:L52	4.28	Yes	Yes	0	0	0
97	N:N:H19	N:N:P20	6.1	No	No	0	0	0
98	N:N:H19	N:N:K21	6.55	No	No	0	0	0
99	N:N:H19	N:N:N22	8.93	No	No	0	0	0
100	N:N:I62	N:N:P20	8.47	No	No	0	0	0
101	N:N:A42	N:N:I23	4.87	No	No	0	0	0
102	N:N:K45	N:N:Q24	5.42	No	No	0	0	0
103	N:N:S25	N:N:T43	3.2	No	No	0	0	0
104	N:N:I63	N:N:V26	3.07	No	No	0	0	0
105	N:N:M66	N:N:V26	4.56	No	No	0	0	0
106	N:N:V28	N:N:V40	6.41	No	No	0	0	0
107	N:N:E39	N:N:K29	4.05	Yes	No	0	0	0
108	N:N:P31	N:N:S30	3.56	No	No	0	0	0
109	N:N:P31	N:N:T38	5.25	No	No	0	0	0
110	N:N:G32	N:N:P33	4.06	No	No	0	0	0
111	N:N:C35	N:N:E39	4.56	No	Yes	11	0	0
112	N:N:L52	N:N:V40	2.98	Yes	No	0	0	0
113	N:N:A42	N:N:L52	3.15	No	Yes	0	0	0
114	N:N:K49	N:N:T43	9.01	No	No	0	0	0
115	N:N:L44	N:N:N46	8.24	No	No	0	0	0
116	N:N:G47	R:R:Y188	5.79	No	No	0	0	1
117	N:N:L52	N:N:V59	8.94	Yes	No	0	0	0
118	N:N:N53	N:N:P54	6.52	Yes	No	0	0	0
119	N:N:A55	N:N:N53	4.69	No	Yes	0	0	0
120	N:N:N53	N:N:S56	4.47	Yes	Yes	0	0	0
121	N:N:P57	N:N:S56	3.56	No	Yes	0	0	0
122	N:N:I58	N:N:S56	4.64	No	Yes	0	0	0
123	N:N:S56	N:N:V59	6.46	Yes	No	0	0	0
124	N:N:I58	N:N:I62	2.94	No	No	0	0	0
125	N:N:E64	N:N:N68	3.94	No	No	10	0	0
126	R:R:C286	R:R:C39	7.28	No	No	0	6	8
127	R:R:C39	R:R:R289	11.14	No	Yes	0	8	3
128	R:R:E45	R:R:K48	4.05	No	No	0	4	4
129	R:R:I301	R:R:V51	7.68	No	No	0	5	5
130	R:R:A105	R:R:V52	3.39	No	No	0	7	5
131	R:R:I301	R:R:I54	2.94	No	No	0	5	5
132	R:R:L101	R:R:Y55	5.86	No	Yes	0	8	7
133	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
134	R:R:I301	R:R:Y55	4.84	No	Yes	0	5	7
135	R:R:I304	R:R:Y55	8.46	No	Yes	0	7	7
136	R:R:L57	R:R:L60	4.15	No	No	0	5	4
137	R:R:L101	R:R:V58	2.98	No	No	0	8	7
138	R:R:I304	R:R:V58	6.14	No	No	0	7	7
139	R:R:C308	R:R:V58	5.12	No	No	0	7	7
140	R:R:F59	R:R:L63	6.09	No	No	0	7	5
141	R:R:F59	R:R:P102	10.11	No	No	0	7	9
142	R:R:C308	R:R:L61	3.17	No	No	0	7	5
143	R:R:S307	R:R:S62	6.52	No	No	0	8	8
144	R:R:C308	R:R:S62	5.16	No	No	0	7	8
145	R:R:L63	R:R:L95	2.77	No	No	0	5	7
146	R:R:L64	R:R:S67	3	No	No	0	4	3
147	R:R:L64	R:R:L68	6.92	No	No	0	4	6
148	R:R:G65	R:R:L68	3.42	No	No	0	7	6
149	R:R:G65	R:R:P311	4.06	No	No	0	7	9
150	R:R:A91	R:R:N66	3.13	No	No	0	8	9
151	R:R:D94	R:R:N66	6.73	Yes	No	0	9	9
152	R:R:L95	R:R:N66	9.61	No	No	0	7	9
153	R:R:F316	R:R:L68	7.31	Yes	No	0	6	6
154	R:R:A91	R:R:V69	3.39	No	No	0	8	8
155	R:R:F316	R:R:V69	3.93	Yes	No	0	6	8
156	R:R:L95	R:R:M70	2.83	No	No	0	7	6
157	R:R:F321	R:R:V72	5.24	No	No	0	8	7
158	R:R:I73	R:R:L88	11.42	No	No	0	6	5
159	R:R:F321	R:R:I73	7.54	No	No	0	8	6
160	R:R:L74	R:R:R80	3.64	No	No	0	2	7
161	R:R:L74	R:R:L88	4.15	No	No	0	2	5
162	R:R:I328	R:R:Y75	4.84	No	No	0	5	4
163	R:R:R77	R:R:R80	3.2	No	No	0	6	7
164	R:R:D84	R:R:S81	8.83	No	No	0	8	7
165	R:R:D143	R:R:V82	5.84	No	No	0	8	7
166	R:R:V162	R:R:V82	9.62	No	No	0	7	7
167	R:R:N89	R:R:V85	4.43	No	No	0	9	6
168	R:R:V162	R:R:V85	3.21	No	No	0	7	6
169	R:R:C139	R:R:Y86	4.03	No	Yes	0	5	7
170	R:R:I140	R:R:Y86	6.04	No	Yes	0	9	7
171	R:R:D143	R:R:Y86	4.6	No	Yes	0	8	7
172	R:R:V162	R:R:Y86	8.83	No	Yes	0	7	7
173	R:R:A315	R:R:L87	3.15	No	No	0	7	7
174	R:R:C166	R:R:N89	7.87	No	No	0	7	9
175	R:R:D94	R:R:L90	6.79	Yes	Yes	12	9	9
176	R:R:L136	R:R:L90	2.77	No	Yes	0	8	9
177	R:R:L137	R:R:L90	5.54	No	Yes	0	8	9
178	R:R:L90	R:R:N310	5.49	Yes	No	12	9	9
179	R:R:D94	R:R:S307	4.42	Yes	No	0	9	8
180	R:R:D94	R:R:N310	12.12	Yes	No	12	9	9
181	R:R:L96	R:R:N129	6.87	No	Yes	0	7	8
182	R:R:F97	R:R:K126	7.44	No	No	0	6	6
183	R:R:F97	R:R:H306	9.05	No	No	0	6	9
184	R:R:A98	R:R:L101	3.15	No	No	0	5	8
185	R:R:T100	R:R:W104	3.64	Yes	No	13	7	6
186	R:R:T100	R:R:V122	4.76	Yes	No	0	7	5
187	R:R:K126	R:R:T100	4.5	No	Yes	13	6	7
188	R:R:K126	R:R:W104	17.4	No	No	13	6	6
189	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
190	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
191	R:R:D297	R:R:K108	2.77	No	No	0	4	5
192	R:R:N110	R:R:V109	8.87	No	No	0	4	4
193	R:R:F114	R:R:W112	5.01	Yes	Yes	0	6	9
194	R:R:G115	R:R:W112	2.81	No	Yes	0	8	9
195	R:R:C119	R:R:W112	7.84	No	Yes	5	9	9
196	R:R:T186	R:R:W112	4.85	Yes	Yes	5	4	9
197	R:R:C196	R:R:W112	7.84	No	Yes	5	9	9
198	R:R:F114	R:R:L118	3.65	Yes	No	0	6	6
199	R:R:T116	R:R:T186	4.71	No	Yes	0	3	4
200	R:R:F117	R:R:V121	5.24	No	No	0	1	5
201	R:R:C119	R:R:T186	3.38	No	Yes	5	9	4
202	R:R:C119	R:R:C196	7.28	No	No	5	9	9
203	R:R:R184	R:R:S123	10.54	Yes	No	0	5	5
204	R:R:L124	R:R:L181	16.61	No	No	0	6	5
205	R:R:L125	R:R:N129	5.49	No	Yes	0	4	8
206	R:R:E127	R:R:Y131	8.98	No	Yes	0	4	7
207	R:R:A177	R:R:E127	3.02	No	No	0	7	4
208	R:R:E127	R:R:V180	12.84	No	No	0	4	4
209	R:R:N129	R:R:V128	4.43	Yes	No	0	8	5
210	R:R:S173	R:R:V128	3.23	No	No	0	7	5
211	R:R:F130	R:R:Y131	9.28	Yes	Yes	0	7	7
212	R:R:F130	R:R:I134	6.28	Yes	Yes	3	7	8
213	R:R:F130	R:R:W264	10.02	Yes	Yes	3	7	8
214	R:R:L176	R:R:Y131	12.89	No	Yes	0	4	7
215	R:R:P215	R:R:Y131	4.17	No	Yes	0	5	7
216	R:R:S132	R:R:W170	14.83	No	No	0	6	9
217	R:R:S132	R:R:S173	6.52	No	No	0	6	7
218	R:R:I134	R:R:P223	3.39	Yes	No	0	8	9
219	R:R:F260	R:R:I134	3.77	Yes	Yes	3	9	8
220	R:R:I134	R:R:W264	5.87	Yes	Yes	3	8	8
221	R:R:I169	R:R:L135	5.71	No	No	0	6	6
222	R:R:I169	R:R:L136	2.85	No	No	0	6	8
223	R:R:L137	R:R:M227	5.65	No	No	0	8	8
224	R:R:L137	R:R:Y314	9.38	No	Yes	0	8	9
225	R:R:C139	R:R:I169	3.27	No	No	0	5	6
226	R:R:I140	R:R:R144	6.26	No	No	4	9	9
227	R:R:I140	R:R:Y314	6.04	No	Yes	4	9	9
228	R:R:M227	R:R:S141	4.6	No	No	0	8	9
229	R:R:C230	R:R:S141	3.44	No	No	0	7	9
230	R:R:S141	R:R:Y231	13.99	No	Yes	0	9	9
231	R:R:C230	R:R:V142	3.42	No	No	0	7	6
232	R:R:D143	R:R:R159	9.53	No	No	0	8	3
233	R:R:R144	R:R:Y231	9.26	No	Yes	0	9	9
234	R:R:R144	R:R:Y314	6.17	No	Yes	4	9	9
235	R:R:L146	R:R:Y145	4.69	No	Yes	0	5	8
236	R:R:V149	R:R:Y145	7.57	Yes	Yes	6	7	8
237	R:R:H150	R:R:Y145	9.8	Yes	Yes	6	6	8
238	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
239	R:R:F233	R:R:Y145	3.09	No	Yes	0	4	8
240	R:R:T234	R:R:Y145	3.75	Yes	Yes	6	8	8
241	R:R:L146	R:R:L155	2.77	No	No	0	5	4
242	R:R:A147	R:R:R159	6.91	No	No	0	8	3
243	R:R:I148	R:R:T234	4.56	No	Yes	0	8	8
244	R:R:I148	R:R:L238	2.85	No	No	0	8	8
245	R:R:H150	R:R:V149	5.54	Yes	Yes	6	6	7
246	R:R:T234	R:R:V149	3.17	Yes	Yes	6	8	7
247	R:R:T237	R:R:V149	6.35	No	Yes	0	5	7
248	R:R:H150	R:R:R153	5.64	Yes	No	0	6	5
249	R:R:H150	R:R:L155	5.14	Yes	No	0	6	4
250	R:R:Q157	R:R:T154	2.83	No	No	0	7	5
251	R:R:K158	R:R:L155	4.23	No	No	0	6	4
252	R:R:L161	R:R:Y160	5.86	No	No	0	4	5
253	R:R:L172	R:R:L176	6.92	No	No	0	4	4
254	R:R:L211	R:R:P179	8.21	No	No	0	4	8
255	R:R:R184	R:R:V180	6.54	Yes	No	0	5	4
256	R:R:F183	R:R:L182	4.87	No	No	0	5	4
257	R:R:F183	R:R:M200	13.68	No	No	0	5	5
258	R:R:C196	R:R:R184	2.79	No	Yes	0	9	5
259	R:R:E198	R:R:R184	19.77	No	Yes	0	5	5
260	R:R:R185	R:R:V187	3.92	No	No	1	4	3
261	R:R:D199	R:R:R185	19.06	No	No	1	4	4
262	R:R:T186	R:R:Y188	3.75	Yes	No	0	4	1
263	R:R:P194	R:R:Y188	11.13	No	No	0	5	1
264	R:R:N191	R:R:S190	5.96	No	No	0	2	2
265	R:R:P194	R:R:S193	3.56	No	No	0	5	3
266	R:R:R208	R:R:Y197	18.52	No	No	0	4	3
267	R:R:R278	R:R:Y197	3.09	Yes	No	0	4	3
268	R:R:E198	R:R:R208	10.47	No	No	0	5	4
269	R:R:M200	R:R:T204	3.01	No	No	0	5	3
270	R:R:M200	R:R:W207	6.98	No	No	0	5	3
271	R:R:N203	R:R:N206	10.9	No	No	0	4	1
272	R:R:L210	R:R:W207	3.42	No	No	0	2	3
273	R:R:M209	R:R:T275	7.53	No	No	0	3	4
274	R:R:M209	R:R:R278	3.72	No	Yes	0	3	4
275	R:R:L271	R:R:R212	10.93	Yes	Yes	0	6	5
276	R:R:D274	R:R:R212	10.72	Yes	Yes	2	4	5
277	R:R:R212	R:R:T275	6.47	Yes	No	0	5	4
278	R:R:I213	R:R:S217	6.19	No	No	0	4	4
279	R:R:N268	R:R:Q216	7.92	No	No	0	8	5
280	R:R:L271	R:R:Q216	5.32	Yes	No	0	6	5
281	R:R:F220	R:R:L224	3.65	Yes	Yes	3	8	7
282	R:R:F220	R:R:F260	4.29	Yes	Yes	3	8	9
283	R:R:F220	R:R:L265	3.65	Yes	No	0	8	6
284	R:R:F220	R:R:N268	15.71	Yes	No	0	8	8
285	R:R:I221	R:R:L225	2.85	No	No	0	4	3
286	R:R:P223	R:R:V222	3.53	No	No	0	9	5
287	R:R:I226	R:R:V222	3.07	No	No	0	6	5
288	R:R:L224	R:R:L228	4.15	Yes	No	0	7	4
289	R:R:F260	R:R:L224	4.87	Yes	Yes	3	9	7
290	R:R:L224	R:R:L261	4.15	Yes	No	0	7	6
291	R:R:F260	R:R:M227	11.2	Yes	No	0	9	8
292	R:R:F229	R:R:F233	7.5	No	No	0	4	4
293	R:R:I253	R:R:Y231	9.67	No	Yes	0	7	9
294	R:R:V256	R:R:Y231	3.79	Yes	Yes	0	8	9
295	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
296	R:R:I253	R:R:T234	3.04	No	Yes	0	7	8
297	R:R:L235	R:R:M250	2.83	No	Yes	0	4	5
298	R:R:I253	R:R:L235	7.14	No	No	0	7	4
299	R:R:F254	R:R:L235	4.87	No	No	0	4	4
300	R:R:L238	R:R:M250	2.83	No	Yes	0	8	5
301	R:R:F239	R:R:M250	6.22	No	Yes	0	5	5
302	R:R:G244	R:R:Q245	3.29	No	No	0	4	4
303	R:R:H247	R:R:K246	7.86	No	No	0	5	7
304	R:R:K246	R:R:M250	5.76	No	Yes	0	7	5
305	R:R:R248	R:R:R322	3.2	No	No	0	7	8
306	R:R:I317	R:R:V252	7.68	No	No	0	6	7
307	R:R:I313	R:R:V256	3.07	No	Yes	4	7	8
308	R:R:V256	R:R:Y314	6.31	Yes	Yes	4	8	9
309	R:R:I259	R:R:L309	4.28	No	No	0	6	6
310	R:R:I259	R:R:I313	7.36	No	No	0	6	7
311	R:R:F260	R:R:W264	3.01	Yes	Yes	3	9	8
312	R:R:W264	R:R:Y267	2.89	Yes	Yes	0	8	7
313	R:R:H306	R:R:W264	7.41	No	Yes	0	9	8
314	R:R:L265	R:R:P266	3.28	No	No	0	6	9
315	R:R:L265	R:R:L269	5.54	No	No	0	6	6
316	R:R:L302	R:R:P266	3.28	No	No	0	7	9
317	R:R:L271	R:R:Y267	7.03	Yes	Yes	0	6	7
318	R:R:T299	R:R:Y267	4.99	No	Yes	0	6	7
319	R:R:E300	R:R:Y267	3.37	No	Yes	0	5	7
320	R:R:A295	R:R:V270	3.39	No	No	0	5	4
321	R:R:L296	R:R:V270	4.47	No	No	0	5	4
322	R:R:T299	R:R:V270	7.93	No	No	0	6	4
323	R:R:L271	R:R:L296	4.15	Yes	No	0	6	5
324	R:R:L272	R:R:L276	2.77	No	No	0	5	4
325	R:R:D274	R:R:R278	8.34	Yes	Yes	2	4	4
326	R:R:L276	R:R:V281	4.47	No	No	0	4	4
327	R:R:E284	R:R:M277	5.41	Yes	Yes	0	3	4
328	R:R:M277	R:R:R288	3.72	Yes	No	0	4	1
329	R:R:I292	R:R:M277	4.37	No	Yes	0	5	4
330	R:R:T279	R:R:V281	3.17	No	No	0	1	4
331	R:R:E284	R:R:Q280	11.47	Yes	No	0	3	2
332	R:R:Q283	R:R:T285	4.25	No	No	0	2	5
333	R:R:E284	R:R:R289	5.82	Yes	Yes	2	3	3
334	R:R:R288	R:R:T285	7.76	No	No	0	1	5
335	R:R:E287	R:R:H291	3.69	No	No	0	4	3
336	R:R:H291	R:R:N290	3.83	No	No	0	3	3
337	R:R:E300	R:R:I304	4.1	No	No	0	5	7
338	R:R:H306	R:R:S307	2.79	No	No	0	9	8
339	R:R:N310	R:R:P311	3.26	No	No	0	9	9
340	R:R:F316	R:R:L312	3.65	Yes	No	0	6	6
341	R:R:I313	R:R:Y314	3.63	No	Yes	4	7	9
342	R:R:A315	R:R:F316	2.77	No	Yes	0	7	6
343	R:R:A315	R:R:F321	8.32	No	No	0	7	8
344	R:R:L325	R:R:L326	4.15	No	No	0	6	4
345	R:R:I328	R:R:K327	2.91	No	No	0	5	4
346	R:R:L44	R:R:N47	2.75	No	No	0	2	4
347	L:L:I41	L:L:Q10	2.74	No	Yes	0	0	0
348	R:R:E300	R:R:K108	2.7	No	No	0	5	5
349	R:R:H323	R:R:K327	2.62	No	No	0	4	4
350	R:R:C263	R:R:W264	2.61	No	Yes	0	7	8
351	R:R:A93	R:R:W170	2.59	No	No	0	8	9
352	R:R:R159	R:R:T156	2.59	No	No	0	3	2
353	N:N:E39	N:N:Q37	2.55	Yes	No	0	0	0
354	R:R:F50	R:R:I46	2.51	No	No	0	5	5
355	R:R:F114	R:R:I103	2.51	Yes	No	0	6	6
356	R:R:L44	R:R:R294	2.43	No	No	0	2	2
357	R:R:I165	R:R:Y86	2.42	No	Yes	0	5	7
358	R:R:F97	R:R:N129	2.42	No	Yes	0	6	8
359	N:N:N46	N:N:R48	2.41	No	No	0	0	0
360	R:R:N203	R:R:W207	2.26	No	No	0	4	3
361	R:R:H247	R:R:R251	2.26	No	No	0	5	5
362	R:R:A37	R:R:P38	1.87	No	No	0	7	7
363	R:R:A138	R:R:P223	1.87	No	No	0	7	9
364	R:R:G133	R:R:S132	1.86	No	No	0	9	6
365	R:R:G324	R:R:V72	1.84	No	No	0	5	7
366	R:R:G201	R:R:T204	1.82	No	No	0	4	3
367	L:L:C51	R:R:A36	1.81	No	No	0	0	5
368	L:L:A36	R:R:A205	1.79	No	No	0	0	1
369	R:R:P41	R:R:V192	1.77	No	No	0	4	5
370	L:L:G17	L:L:I58	1.76	No	No	0	0	0
371	R:R:G318	R:R:I317	1.76	No	No	0	7	6
372	L:L:P33	R:R:T204	1.75	Yes	No	0	0	3
373	N:N:P54	N:N:T38	1.75	No	No	0	0	0
374	R:R:G244	R:R:M243	1.75	No	No	0	4	4
375	L:L:A1	R:R:S193	1.71	No	No	0	0	3
376	R:R:G171	R:R:L174	1.71	No	No	0	4	5
377	R:R:G303	R:R:L302	1.71	No	No	0	7	7
378	L:L:A4	R:R:V192	1.7	No	No	0	0	5
379	L:L:G47	L:L:N46	1.7	No	No	0	0	0
380	N:N:G47	N:N:N46	1.7	No	No	0	0	0
381	L:L:I41	R:R:P38	1.69	No	No	0	0	7
382	N:N:C51	N:N:T14	1.69	No	No	0	0	0
383	L:L:P54	N:N:L67	1.64	No	No	0	0	0
384	R:R:L178	R:R:P179	1.64	No	No	0	3	8
385	R:R:L214	R:R:P215	1.64	No	No	0	3	5
386	R:R:G318	R:R:Q319	1.64	No	No	0	7	5
387	R:R:N191	R:R:P41	1.63	No	No	0	2	4
388	R:R:S189	R:R:S190	1.63	No	No	0	1	2
389	R:R:S76	R:R:V78	1.62	No	No	0	4	5
390	R:R:A273	R:R:I292	1.62	No	No	0	5	5
391	R:R:A241	R:R:M243	1.61	No	No	0	3	4
392	R:R:V109	R:R:V52	1.6	No	No	0	4	5
393	R:R:V252	R:R:V256	1.6	No	Yes	0	7	8
394	R:R:C263	R:R:L305	1.59	No	No	0	7	5
395	R:R:G324	R:R:H323	1.59	No	No	0	5	4
396	L:L:Q24	N:N:P33	1.58	No	No	0	0	0
397	R:R:A177	R:R:L124	1.58	No	No	0	7	6
398	R:R:A249	R:R:L238	1.58	No	No	0	7	8
399	R:R:T275	R:R:T279	1.57	No	No	0	4	1
400	L:L:A36	R:R:N203	1.56	No	No	0	0	4
401	R:R:A205	R:R:N206	1.56	No	No	0	1	1
402	R:R:I165	R:R:S168	1.55	No	No	0	5	2
403	R:R:K320	R:R:S81	1.53	No	No	0	6	7
404	R:R:F130	R:R:G219	1.51	Yes	No	0	7	5
405	R:R:K120	R:R:T116	1.5	No	No	0	7	3
406	R:R:G318	R:R:R322	1.5	No	No	0	7	8
407	R:R:L325	R:R:V72	1.49	No	No	0	6	7
408	R:R:L174	R:R:V128	1.49	No	No	0	5	5
409	R:R:L87	R:R:T83	1.47	No	No	0	7	7
410	R:R:L99	R:R:T100	1.47	No	Yes	0	4	7
411	R:R:I282	R:R:M277	1.46	No	Yes	0	5	4
412	L:L:Q24	N:N:S30	1.44	No	No	0	0	0
413	R:R:Q216	R:R:S217	1.44	No	No	0	5	4
414	R:R:K246	R:R:M243	1.44	No	No	0	7	4
415	N:N:I18	N:N:L15	1.43	Yes	No	0	0	0
416	R:R:Q157	R:R:T156	1.42	No	No	0	7	2
417	R:R:E287	R:R:T285	1.41	No	No	0	4	5
418	L:L:K45	L:L:N22	1.4	No	No	0	0	0
419	R:R:D84	R:R:I73	1.4	No	No	0	8	6
420	R:R:L92	R:R:L96	1.38	No	No	0	6	7
421	R:R:L174	R:R:L175	1.38	No	No	0	5	4
422	R:R:L326	R:R:L329	1.38	No	No	0	4	6
423	R:R:F218	R:R:S217	1.32	No	No	0	4	4
424	R:R:E42	R:R:N290	1.31	No	No	0	4	3
425	R:R:R153	R:R:T152	1.29	No	No	0	5	5
426	R:R:S76	R:R:Y75	1.27	No	No	0	4	4
427	R:R:V52	R:R:Y49	1.26	No	No	0	5	2
428	R:R:F50	R:R:I53	1.26	No	No	0	5	5
429	R:R:F117	R:R:L118	1.22	No	No	0	1	6
430	R:R:K48	R:R:Y49	1.19	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E6	5.81833	6	2	0
2	L:L:R8	9.334	5	2	0
3	L:L:Q10	5.2975	4	0	0
4	L:L:K29	4.1425	4	1	0
5	L:L:P33	4.46143	7	1	0
6	L:L:H34	4.3475	4	1	0
7	L:L:E39	6.655	4	7	0
8	L:L:L44	5.7425	4	8	0
9	L:L:L52	5.21	4	0	0
10	L:L:N53	4.65	4	0	0
11	L:L:S56	4.38	4	0	0
12	L:L:K60	6.525	4	10	0
13	L:L:L67	5	4	0	0
14	N:N:I18	4.3375	4	0	0
15	N:N:E39	5.272	5	11	0
16	N:N:L52	4.8375	4	0	0
17	N:N:N53	5.3825	4	0	0
18	N:N:S56	4.7825	4	0	0
19	R:R:Y55	5.79	4	0	7
20	R:R:Y86	5.184	5	0	7
21	R:R:L90	5.1475	4	12	9
22	R:R:D94	7.515	4	12	9
23	R:R:T100	3.5925	4	13	7
24	R:R:W112	5.96	6	5	9
25	R:R:F114	3.485	4	0	6
26	R:R:N129	4.8025	4	0	8
27	R:R:F130	6.7725	4	3	7
28	R:R:Y131	8.83	4	0	7
29	R:R:I134	4.8275	4	3	8
30	R:R:Y145	5.93667	6	6	8
31	R:R:V149	5.6575	4	6	7
32	R:R:H150	6.53	4	6	6
33	R:R:R184	9.91	4	0	5
34	R:R:T186	4.1725	4	5	4
35	R:R:R212	7.9025	4	2	5
36	R:R:F220	6.825	4	3	8
37	R:R:L224	4.205	4	3	7
38	R:R:Y231	8.352	5	0	9
39	R:R:T234	3.63	4	6	8
40	R:R:M250	4.41	4	0	5
41	R:R:V256	3.6925	4	4	8
42	R:R:F260	5.428	5	3	9
43	R:R:W264	5.30167	6	3	8
44	R:R:Y267	4.57	4	0	7
45	R:R:L271	6.8575	4	0	6
46	R:R:D274	8.475	4	2	4
47	R:R:M277	3.74	4	0	4
48	R:R:R278	7.838	5	2	4
49	R:R:E284	6.67	4	2	3
50	R:R:R289	7.815	4	2	3
51	R:R:Y314	6.306	5	4	9
52	R:R:F316	4.415	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E6	R:R:R208	28.1191	10.47	Yes	No	0	0	4
2	R:R:E198	R:R:R208	29.062	10.47	No	No	0	5	4
3	R:R:E198	R:R:R184	29.2811	19.77	No	Yes	0	5	5
4	R:R:C196	R:R:R184	100	2.79	No	Yes	0	9	5
5	R:R:C196	R:R:W112	51.8484	7.84	No	Yes	5	9	9
6	R:R:T186	R:R:W112	48.4264	4.85	Yes	Yes	5	4	9
7	R:R:T186	R:R:Y188	93.2755	3.75	Yes	No	0	4	1
8	R:R:C119	R:R:C196	47.8969	7.28	No	No	5	9	9
9	R:R:C119	R:R:T186	47.5167	3.38	No	Yes	5	9	4
10	L:L:E6	L:L:R8	10.3514	4.65	Yes	Yes	2	0	0
11	L:L:E6	R:R:R212	39.5876	3.49	Yes	Yes	2	0	5
12	L:L:E6	R:R:R278	12.9455	6.98	Yes	Yes	2	0	4
13	R:R:R208	R:R:Y197	25.3912	18.52	No	No	0	4	3
14	R:R:R278	R:R:Y197	26.3791	3.09	Yes	No	0	4	3
15	L:L:H34	L:L:L7	48.7936	3.86	Yes	No	0	0	0
16	L:L:L7	R:R:Y197	49.7755	19.93	No	No	0	0	3
17	L:L:R8	R:R:R289	15.2222	10.66	Yes	Yes	2	0	3
18	L:L:K29	L:L:Q10	20.3594	4.07	Yes	Yes	0	0	0
19	L:L:H34	L:L:K29	28.6687	5.24	Yes	Yes	1	0	0
20	R:R:E284	R:R:R289	11.0396	5.82	Yes	Yes	2	3	3
21	L:L:N53	L:L:S56	11.0479	4.47	Yes	Yes	0	0	0
22	L:L:S56	L:L:V59	21.7322	4.85	Yes	No	0	0	0
23	L:L:I63	L:L:V59	36.3254	3.07	No	No	0	0	0
24	L:L:I63	L:L:L67	38.377	2.85	No	Yes	0	0	0
25	L:L:L67	N:N:V28	47.705	2.98	Yes	No	0	0	0
26	N:N:V28	N:N:V40	48.7107	6.41	No	No	0	0	0
27	N:N:L52	N:N:V40	49.7139	2.98	Yes	No	0	0	0
28	N:N:I18	N:N:L52	78.6184	4.28	Yes	Yes	0	0	0
29	N:N:I18	N:N:L44	84.2543	4.28	Yes	No	0	0	0
30	N:N:L44	N:N:N46	85.1699	8.24	No	No	0	0	0
31	N:N:G47	N:N:N46	86.9941	1.7	No	No	0	0	0
32	N:N:G47	R:R:Y188	87.8742	5.79	No	No	0	0	1
33	L:L:L52	L:L:V59	14.2734	8.94	Yes	No	0	0	0
34	L:L:H34	L:L:P33	18.2225	4.58	Yes	Yes	1	0	0
35	N:N:L52	N:N:V59	30.2465	8.94	Yes	No	0	0	0
36	N:N:S56	N:N:V59	29.1982	6.46	Yes	No	0	0	0
37	N:N:N53	N:N:S56	20.7266	4.47	Yes	Yes	0	0	0
38	N:N:N53	N:N:T14	11.0148	5.85	Yes	No	0	0	0
39	R:R:R184	R:R:V180	73.9514	6.54	Yes	No	0	5	4
40	R:R:E127	R:R:V180	73.9668	12.84	No	No	0	4	4
41	R:R:E127	R:R:Y131	74.0616	8.98	No	Yes	0	4	7
42	R:R:F130	R:R:Y131	74.4525	9.28	Yes	Yes	0	7	7
43	R:R:F130	R:R:W264	49.438	10.02	Yes	Yes	3	7	8
44	R:R:W264	R:R:Y267	49.4735	2.89	Yes	Yes	0	8	7
45	R:R:E300	R:R:Y267	18.1159	3.37	No	Yes	0	5	7
46	R:R:E300	R:R:I304	15.3371	4.1	No	No	0	5	7
47	R:R:I304	R:R:Y55	12.1258	8.46	No	Yes	0	7	7
48	R:R:L271	R:R:R212	57.1254	10.93	Yes	Yes	0	6	5
49	R:R:L271	R:R:Y267	51.6482	7.03	Yes	Yes	0	6	7
50	R:R:H306	R:R:W264	38.4765	7.41	No	Yes	0	9	8
51	R:R:H306	R:R:S307	27.9343	2.79	No	No	0	9	8
52	R:R:D94	R:R:S307	28.298	4.42	Yes	No	0	9	8
53	R:R:D94	R:R:N66	25.1578	6.73	Yes	No	0	9	9
54	R:R:A91	R:R:N66	20.7799	3.13	No	No	0	8	9
55	R:R:A91	R:R:V69	20.0443	3.39	No	No	0	8	8
56	R:R:F316	R:R:V69	19.3087	3.93	Yes	No	0	6	8
57	R:R:A315	R:R:F316	21.7938	2.77	No	Yes	0	7	6
58	R:R:A315	R:R:F321	19.0221	8.32	No	No	0	7	8
59	R:R:F321	R:R:V72	10.5789	5.24	No	No	0	8	7
60	R:R:F130	R:R:I134	25.5606	6.28	Yes	Yes	3	7	8
61	R:R:F260	R:R:I134	24.8913	3.77	Yes	Yes	3	9	8
62	R:R:F260	R:R:M227	70.8279	11.2	Yes	No	0	9	8
63	R:R:L137	R:R:M227	33.3179	5.65	No	No	0	8	8
64	R:R:L137	R:R:Y314	30.6445	9.38	No	Yes	0	8	9
65	R:R:I140	R:R:Y314	16.1271	6.04	No	Yes	4	9	9
66	R:R:I140	R:R:Y86	16.2527	6.04	No	Yes	0	9	7
67	R:R:F260	R:R:W264	50.8771	3.01	Yes	Yes	3	9	8
68	R:R:L137	R:R:L90	14.9663	5.54	No	Yes	0	8	9
69	R:R:D94	R:R:L90	10.3171	6.79	Yes	Yes	12	9	9
70	R:R:F97	R:R:H306	14.3575	9.05	No	No	0	6	9
71	R:R:M227	R:R:S141	43.7914	4.6	No	No	0	8	9
72	R:R:S141	R:R:Y231	25.7679	13.99	No	Yes	0	9	9
73	R:R:C230	R:R:S141	18.2154	3.44	No	No	0	7	9
74	R:R:C230	R:R:Y145	16.3368	6.72	No	Yes	0	7	8
75	R:R:I253	R:R:Y231	21.2253	9.67	No	Yes	0	7	9
76	R:R:I253	R:R:L235	15.1298	7.14	No	No	0	7	4
77	R:R:L235	R:R:M250	12.82	2.83	No	Yes	0	4	5
78	L:L:P33	R:R:T204	12.9621	1.75	Yes	No	0	0	3
79	R:R:M200	R:R:T204	10.8252	3.01	No	No	0	5	3
80	R:R:V252	R:R:V256	11.2078	1.6	No	Yes	0	7	8
81	R:R:D274	R:R:R212	17.7392	10.72	Yes	Yes	2	4	5
82	R:R:D274	R:R:R278	12.377	8.34	Yes	Yes	2	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S2	R:R:S43	6.52	0	No	No	0	5	0	1
L:L:V3	R:R:G111	3.68	0	No	No	0	4	0	1
L:L:V3	R:R:S193	3.23	0	No	No	0	3	0	1
L:L:E6	R:R:R208	10.47	2	Yes	No	0	4	0	1
L:L:E6	R:R:R212	3.49	2	Yes	Yes	0	5	0	1
L:L:E6	R:R:D274	6.5	2	Yes	Yes	0	4	0	1
L:L:E6	R:R:R278	6.98	2	Yes	Yes	0	4	0	1
L:L:L7	R:R:Y197	19.93	0	No	No	0	3	0	1
L:L:R8	R:R:D274	8.34	2	Yes	Yes	0	4	0	1
L:L:R8	R:R:R278	17.06	2	Yes	Yes	0	4	0	1
L:L:R8	R:R:R289	10.66	2	Yes	Yes	0	3	0	1
L:L:R8	R:R:D293	5.96	2	Yes	No	0	4	0	1
L:L:Q10	R:R:N191	10.56	0	Yes	No	0	2	0	1
L:L:L12	R:R:E284	3.98	2	No	Yes	0	3	0	1
L:L:L12	R:R:R289	3.64	2	No	Yes	0	3	0	1
L:L:L15	R:R:A36	4.73	0	No	No	0	5	0	1
L:L:P33	R:R:R185	2.88	1	Yes	No	0	4	0	1
L:L:P33	R:R:V187	3.53	1	Yes	No	0	3	0	1
L:L:P33	R:R:D199	11.27	1	Yes	No	0	4	0	1
L:L:K49	R:R:P38	3.35	0	No	No	0	7	0	1
L:L:K49	R:R:E40	5.4	0	No	No	0	4	0	1
N:N:G47	R:R:Y188	5.79	0	No	No	0	1	0	1
R:R:C39	R:R:R289	11.14	0	No	Yes	8	3	2	1
R:R:R185	R:R:V187	3.92	1	No	No	4	3	1	1
R:R:D199	R:R:R185	19.06	1	No	No	4	4	1	1
R:R:T186	R:R:Y188	3.75	5	Yes	No	4	1	2	1
R:R:P194	R:R:Y188	11.13	0	No	No	5	1	2	1
R:R:N191	R:R:S190	5.96	0	No	No	2	2	1	2
R:R:P194	R:R:S193	3.56	0	No	No	5	3	2	1
R:R:R208	R:R:Y197	18.52	0	No	No	4	3	1	1
R:R:R278	R:R:Y197	3.09	2	Yes	No	4	3	1	1
R:R:E198	R:R:R208	10.47	0	No	No	5	4	2	1
R:R:M200	R:R:T204	3.01	0	No	No	5	3	2	1
R:R:M200	R:R:W207	6.98	0	No	No	5	3	2	2
R:R:N203	R:R:N206	10.9	0	No	No	4	1	1	2
R:R:M209	R:R:T275	7.53	0	No	No	3	4	2	2
R:R:M209	R:R:R278	3.72	0	No	Yes	3	4	2	1
R:R:L271	R:R:R212	10.93	0	Yes	Yes	6	5	2	1
R:R:D274	R:R:R212	10.72	2	Yes	Yes	4	5	1	1
R:R:R212	R:R:T275	6.47	2	Yes	No	5	4	1	2
R:R:D274	R:R:R278	8.34	2	Yes	Yes	4	4	1	1
R:R:E284	R:R:M277	5.41	2	Yes	Yes	3	4	1	2
R:R:E284	R:R:Q280	11.47	2	Yes	No	3	2	1	2
R:R:E284	R:R:R289	5.82	2	Yes	Yes	3	3	1	1
R:R:N203	R:R:W207	2.26	0	No	No	4	3	1	2
R:R:A37	R:R:P38	1.87	0	No	No	7	7	2	1
R:R:G201	R:R:T204	1.82	0	No	No	4	3	2	1
L:L:C51	R:R:A36	1.81	0	No	No	0	5	0	1
L:L:A36	R:R:A205	1.79	0	No	No	0	1	0	1
R:R:P41	R:R:V192	1.77	0	No	No	4	5	2	1
L:L:P33	R:R:T204	1.75	1	Yes	No	0	3	0	1
L:L:A1	R:R:S193	1.71	0	No	No	0	3	0	1
L:L:A4	R:R:V192	1.7	0	No	No	0	5	0	1
L:L:I41	R:R:P38	1.69	0	No	No	0	7	0	1
R:R:N191	R:R:P41	1.63	0	No	No	2	4	1	2
L:L:A36	R:R:N203	1.56	0	No	No	0	4	0	1
R:R:A205	R:R:N206	1.56	0	No	No	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XWV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	394
Number of Links	430
Number of Hubs	52
Number of Links mediated by Hubs	186
Number of Communities	13
Number of Nodes involved in Communities	57
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	167684
Length Of Smallest Path	3
Average Path Length	19.8152
Length of Longest Path	43
Minimum Path Strength	1.225
Average Path Strength	6.15767
Maximum Path Strength	19.225
Minimum Path Correlation	0.7
Average Path Correlation	0.952343
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	50.2526
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3255
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XWV_nogp_Chain_R D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	doi.org/10.1038/s41586-020-2492-5
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	doi.org/10.1016/j.molcel.2025.01.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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