psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S2	R:R:S43	6.52	No	No	0	0	5
2	L:L:V3	R:R:G111	3.68	No	No	0	0	4
3	L:L:V3	R:R:S193	3.23	No	No	0	0	3
4	L:L:E6	L:L:T5	2.82	Yes	No	0	0	0
5	L:L:E6	L:L:R8	4.65	Yes	Yes	2	0	0
6	L:L:E6	R:R:R208	10.47	Yes	No	0	0	4
7	L:L:E6	R:R:R212	3.49	Yes	Yes	2	0	5
8	L:L:E6	R:R:D274	6.5	Yes	Yes	2	0	4
9	L:L:E6	R:R:R278	6.98	Yes	Yes	2	0	4
10	L:L:H34	L:L:L7	3.86	Yes	No	0	0	0
11	L:L:L7	R:R:Y197	19.93	No	No	0	0	3
12	L:L:R8	R:R:D274	8.34	Yes	Yes	2	0	4
13	L:L:R8	R:R:R278	17.06	Yes	Yes	2	0	4
14	L:L:R8	R:R:R289	10.66	Yes	Yes	2	0	3
15	L:L:R8	R:R:D293	5.96	Yes	No	0	0	4
16	L:L:C35	L:L:C9	7.28	No	No	7	0	0
17	L:L:C9	L:L:E39	9.12	No	Yes	7	0	0
18	L:L:K29	L:L:Q10	4.07	Yes	Yes	0	0	0
19	L:L:E39	L:L:Q10	3.82	Yes	Yes	0	0	0
20	L:L:Q10	R:R:N191	10.56	Yes	No	0	0	2
21	L:L:C11	L:L:E39	4.56	No	Yes	0	0	0
22	L:L:C11	L:L:C51	5.46	No	No	0	0	0
23	L:L:L12	L:L:Q13	6.65	No	No	0	0	0
24	L:L:L12	R:R:E284	3.98	No	Yes	2	0	3
25	L:L:L12	R:R:R289	3.64	No	Yes	2	0	3
26	L:L:N53	L:L:T14	2.92	Yes	No	0	0	0
27	L:L:L15	R:R:A36	4.73	No	No	0	0	5
28	L:L:I18	L:L:I23	8.83	No	No	0	0	0
29	L:L:I18	L:L:L44	2.85	No	Yes	0	0	0
30	L:L:I18	L:L:L52	4.28	No	Yes	0	0	0
31	L:L:H19	L:L:P20	7.63	No	No	0	0	0
32	L:L:H19	L:L:K21	5.24	No	No	0	0	0
33	L:L:I62	L:L:P20	3.39	No	No	9	0	0
34	L:L:M66	L:L:P20	3.35	No	No	9	0	0
35	L:L:L44	L:L:N22	9.61	Yes	No	0	0	0
36	L:L:S25	L:L:T43	4.8	No	No	0	0	0
37	L:L:S25	N:N:N27	2.98	No	No	0	0	0
38	L:L:I63	L:L:V26	3.07	No	No	0	0	0
39	L:L:K29	L:L:N27	4.2	Yes	No	1	0	0
40	L:L:N27	N:N:S25	2.98	No	No	1	0	0
41	L:L:N27	N:N:N27	12.26	No	No	0	0	0
42	L:L:V28	L:L:V40	6.41	No	No	0	0	0
43	L:L:H34	L:L:K29	5.24	Yes	Yes	1	0	0
44	L:L:K29	N:N:S25	3.06	Yes	No	1	0	0
45	L:L:P31	L:L:S30	3.56	No	No	0	0	0
46	L:L:S30	N:N:M66	4.6	No	No	0	0	0
47	L:L:P31	L:L:T38	6.99	No	No	0	0	0
48	L:L:P31	N:N:S69	7.13	No	No	0	0	0
49	L:L:G32	L:L:P33	4.06	No	Yes	0	0	0
50	L:L:H34	L:L:P33	4.58	Yes	Yes	1	0	0
51	L:L:P33	N:N:Q24	3.16	Yes	No	1	0	0
52	L:L:P33	R:R:R185	2.88	Yes	No	1	0	4
53	L:L:P33	R:R:V187	3.53	Yes	No	1	0	3
54	L:L:P33	R:R:D199	11.27	Yes	No	1	0	4
55	L:L:H34	N:N:Q24	3.71	Yes	No	1	0	0
56	L:L:C35	L:L:E39	9.12	No	Yes	7	0	0
57	L:L:P54	L:L:T38	5.25	No	No	0	0	0
58	L:L:L52	L:L:V40	4.47	Yes	No	0	0	0
59	L:L:A42	L:L:L52	3.15	No	Yes	0	0	0
60	L:L:L44	L:L:N46	6.87	Yes	No	8	0	0
61	L:L:L44	L:L:R48	3.64	Yes	No	8	0	0
62	L:L:N46	L:L:R48	3.62	No	No	8	0	0
63	L:L:A50	L:L:R48	4.15	No	No	0	0	0
64	L:L:K49	R:R:P38	3.35	No	No	0	0	7
65	L:L:K49	R:R:E40	5.4	No	No	0	0	4
66	L:L:L52	L:L:V59	8.94	Yes	No	0	0	0
67	L:L:N53	L:L:P54	6.52	Yes	No	0	0	0
68	L:L:A55	L:L:N53	4.69	No	Yes	0	0	0
69	L:L:N53	L:L:S56	4.47	Yes	Yes	0	0	0
70	L:L:P57	L:L:S56	3.56	No	Yes	0	0	0
71	L:L:I58	L:L:S56	4.64	No	Yes	0	0	0
72	L:L:S56	L:L:V59	4.85	Yes	No	0	0	0
73	L:L:I58	L:L:I62	2.94	No	No	0	0	0
74	L:L:I63	L:L:V59	3.07	No	No	0	0	0
75	L:L:E64	L:L:K60	4.05	No	Yes	0	0	0
76	L:L:K60	N:N:E64	10.8	Yes	No	10	0	0
77	L:L:K60	N:N:L67	7.05	Yes	No	0	0	0
78	L:L:K60	N:N:N68	4.2	Yes	No	10	0	0
79	L:L:I62	L:L:M66	2.92	No	No	9	0	0
80	L:L:I63	L:L:L67	2.85	No	Yes	0	0	0
81	L:L:K65	L:L:M66	2.88	No	No	0	0	0
82	L:L:L67	N:N:V28	2.98	Yes	No	0	0	0
83	L:L:L67	N:N:K60	8.46	Yes	No	0	0	0
84	L:L:L67	N:N:I63	5.71	Yes	No	0	0	0
85	N:N:C35	N:N:C9	7.28	No	No	11	0	0
86	N:N:C9	N:N:E39	6.08	No	Yes	11	0	0
87	N:N:K29	N:N:Q10	4.07	No	No	0	0	0
88	N:N:C11	N:N:E39	9.12	No	Yes	0	0	0
89	N:N:C11	N:N:I41	3.27	No	No	0	0	0
90	N:N:C11	N:N:C51	7.28	No	No	0	0	0
91	N:N:N53	N:N:T14	5.85	Yes	No	0	0	0
92	N:N:L15	N:N:Q16	9.32	No	No	0	0	0
93	N:N:G17	N:N:Q16	3.29	No	No	0	0	0
94	N:N:I18	N:N:I23	7.36	Yes	No	0	0	0
95	N:N:I18	N:N:L44	4.28	Yes	No	0	0	0
96	N:N:I18	N:N:L52	4.28	Yes	Yes	0	0	0
97	N:N:H19	N:N:P20	6.1	No	No	0	0	0
98	N:N:H19	N:N:K21	6.55	No	No	0	0	0
99	N:N:H19	N:N:N22	8.93	No	No	0	0	0
100	N:N:I62	N:N:P20	8.47	No	No	0	0	0
101	N:N:A42	N:N:I23	4.87	No	No	0	0	0
102	N:N:K45	N:N:Q24	5.42	No	No	0	0	0
103	N:N:S25	N:N:T43	3.2	No	No	0	0	0
104	N:N:I63	N:N:V26	3.07	No	No	0	0	0
105	N:N:M66	N:N:V26	4.56	No	No	0	0	0
106	N:N:V28	N:N:V40	6.41	No	No	0	0	0
107	N:N:E39	N:N:K29	4.05	Yes	No	0	0	0
108	N:N:P31	N:N:S30	3.56	No	No	0	0	0
109	N:N:P31	N:N:T38	5.25	No	No	0	0	0
110	N:N:G32	N:N:P33	4.06	No	No	0	0	0
111	N:N:C35	N:N:E39	4.56	No	Yes	11	0	0
112	N:N:L52	N:N:V40	2.98	Yes	No	0	0	0
113	N:N:A42	N:N:L52	3.15	No	Yes	0	0	0
114	N:N:K49	N:N:T43	9.01	No	No	0	0	0
115	N:N:L44	N:N:N46	8.24	No	No	0	0	0
116	N:N:G47	R:R:Y188	5.79	No	No	0	0	1
117	N:N:L52	N:N:V59	8.94	Yes	No	0	0	0
118	N:N:N53	N:N:P54	6.52	Yes	No	0	0	0
119	N:N:A55	N:N:N53	4.69	No	Yes	0	0	0
120	N:N:N53	N:N:S56	4.47	Yes	Yes	0	0	0
121	N:N:P57	N:N:S56	3.56	No	Yes	0	0	0
122	N:N:I58	N:N:S56	4.64	No	Yes	0	0	0
123	N:N:S56	N:N:V59	6.46	Yes	No	0	0	0
124	N:N:I58	N:N:I62	2.94	No	No	0	0	0
125	N:N:E64	N:N:N68	3.94	No	No	10	0	0
126	R:R:C286	R:R:C39	7.28	No	No	0	6	8
127	R:R:C39	R:R:R289	11.14	No	Yes	0	8	3
128	R:R:E45	R:R:K48	4.05	No	No	0	4	4
129	R:R:I301	R:R:V51	7.68	No	No	0	5	5
130	R:R:A105	R:R:V52	3.39	No	No	0	7	5
131	R:R:I301	R:R:I54	2.94	No	No	0	5	5
132	R:R:L101	R:R:Y55	5.86	No	Yes	0	8	7
133	R:R:A105	R:R:Y55	4	No	Yes	0	7	7
134	R:R:I301	R:R:Y55	4.84	No	Yes	0	5	7
135	R:R:I304	R:R:Y55	8.46	No	Yes	0	7	7
136	R:R:L57	R:R:L60	4.15	No	No	0	5	4
137	R:R:L101	R:R:V58	2.98	No	No	0	8	7
138	R:R:I304	R:R:V58	6.14	No	No	0	7	7
139	R:R:C308	R:R:V58	5.12	No	No	0	7	7
140	R:R:F59	R:R:L63	6.09	No	No	0	7	5
141	R:R:F59	R:R:P102	10.11	No	No	0	7	9
142	R:R:C308	R:R:L61	3.17	No	No	0	7	5
143	R:R:S307	R:R:S62	6.52	No	No	0	8	8
144	R:R:C308	R:R:S62	5.16	No	No	0	7	8
145	R:R:L63	R:R:L95	2.77	No	No	0	5	7
146	R:R:L64	R:R:S67	3	No	No	0	4	3
147	R:R:L64	R:R:L68	6.92	No	No	0	4	6
148	R:R:G65	R:R:L68	3.42	No	No	0	7	6
149	R:R:G65	R:R:P311	4.06	No	No	0	7	9
150	R:R:A91	R:R:N66	3.13	No	No	0	8	9
151	R:R:D94	R:R:N66	6.73	Yes	No	0	9	9
152	R:R:L95	R:R:N66	9.61	No	No	0	7	9
153	R:R:F316	R:R:L68	7.31	Yes	No	0	6	6
154	R:R:A91	R:R:V69	3.39	No	No	0	8	8
155	R:R:F316	R:R:V69	3.93	Yes	No	0	6	8
156	R:R:L95	R:R:M70	2.83	No	No	0	7	6
157	R:R:F321	R:R:V72	5.24	No	No	0	8	7
158	R:R:I73	R:R:L88	11.42	No	No	0	6	5
159	R:R:F321	R:R:I73	7.54	No	No	0	8	6
160	R:R:L74	R:R:R80	3.64	No	No	0	2	7
161	R:R:L74	R:R:L88	4.15	No	No	0	2	5
162	R:R:I328	R:R:Y75	4.84	No	No	0	5	4
163	R:R:R77	R:R:R80	3.2	No	No	0	6	7
164	R:R:D84	R:R:S81	8.83	No	No	0	8	7
165	R:R:D143	R:R:V82	5.84	No	No	0	8	7
166	R:R:V162	R:R:V82	9.62	No	No	0	7	7
167	R:R:N89	R:R:V85	4.43	No	No	0	9	6
168	R:R:V162	R:R:V85	3.21	No	No	0	7	6
169	R:R:C139	R:R:Y86	4.03	No	Yes	0	5	7
170	R:R:I140	R:R:Y86	6.04	No	Yes	0	9	7
171	R:R:D143	R:R:Y86	4.6	No	Yes	0	8	7
172	R:R:V162	R:R:Y86	8.83	No	Yes	0	7	7
173	R:R:A315	R:R:L87	3.15	No	No	0	7	7
174	R:R:C166	R:R:N89	7.87	No	No	0	7	9
175	R:R:D94	R:R:L90	6.79	Yes	Yes	12	9	9
176	R:R:L136	R:R:L90	2.77	No	Yes	0	8	9
177	R:R:L137	R:R:L90	5.54	No	Yes	0	8	9
178	R:R:L90	R:R:N310	5.49	Yes	No	12	9	9
179	R:R:D94	R:R:S307	4.42	Yes	No	0	9	8
180	R:R:D94	R:R:N310	12.12	Yes	No	12	9	9
181	R:R:L96	R:R:N129	6.87	No	Yes	0	7	8
182	R:R:F97	R:R:K126	7.44	No	No	0	6	6
183	R:R:F97	R:R:H306	9.05	No	No	0	6	9
184	R:R:A98	R:R:L101	3.15	No	No	0	5	8
185	R:R:T100	R:R:W104	3.64	Yes	No	13	7	6
186	R:R:T100	R:R:V122	4.76	Yes	No	0	7	5
187	R:R:K126	R:R:T100	4.5	No	Yes	13	6	7
188	R:R:K126	R:R:W104	17.4	No	No	13	6	6
189	R:R:A106	R:R:F114	2.77	No	Yes	0	4	6
190	R:R:S107	R:R:W112	7.41	No	Yes	0	5	9
191	R:R:D297	R:R:K108	2.77	No	No	0	4	5
192	R:R:N110	R:R:V109	8.87	No	No	0	4	4
193	R:R:F114	R:R:W112	5.01	Yes	Yes	0	6	9
194	R:R:G115	R:R:W112	2.81	No	Yes	0	8	9
195	R:R:C119	R:R:W112	7.84	No	Yes	5	9	9
196	R:R:T186	R:R:W112	4.85	Yes	Yes	5	4	9
197	R:R:C196	R:R:W112	7.84	No	Yes	5	9	9
198	R:R:F114	R:R:L118	3.65	Yes	No	0	6	6
199	R:R:T116	R:R:T186	4.71	No	Yes	0	3	4
200	R:R:F117	R:R:V121	5.24	No	No	0	1	5
201	R:R:C119	R:R:T186	3.38	No	Yes	5	9	4
202	R:R:C119	R:R:C196	7.28	No	No	5	9	9
203	R:R:R184	R:R:S123	10.54	Yes	No	0	5	5
204	R:R:L124	R:R:L181	16.61	No	No	0	6	5
205	R:R:L125	R:R:N129	5.49	No	Yes	0	4	8
206	R:R:E127	R:R:Y131	8.98	No	Yes	0	4	7
207	R:R:A177	R:R:E127	3.02	No	No	0	7	4
208	R:R:E127	R:R:V180	12.84	No	No	0	4	4
209	R:R:N129	R:R:V128	4.43	Yes	No	0	8	5
210	R:R:S173	R:R:V128	3.23	No	No	0	7	5
211	R:R:F130	R:R:Y131	9.28	Yes	Yes	0	7	7
212	R:R:F130	R:R:I134	6.28	Yes	Yes	3	7	8
213	R:R:F130	R:R:W264	10.02	Yes	Yes	3	7	8
214	R:R:L176	R:R:Y131	12.89	No	Yes	0	4	7
215	R:R:P215	R:R:Y131	4.17	No	Yes	0	5	7
216	R:R:S132	R:R:W170	14.83	No	No	0	6	9
217	R:R:S132	R:R:S173	6.52	No	No	0	6	7
218	R:R:I134	R:R:P223	3.39	Yes	No	0	8	9
219	R:R:F260	R:R:I134	3.77	Yes	Yes	3	9	8
220	R:R:I134	R:R:W264	5.87	Yes	Yes	3	8	8
221	R:R:I169	R:R:L135	5.71	No	No	0	6	6
222	R:R:I169	R:R:L136	2.85	No	No	0	6	8
223	R:R:L137	R:R:M227	5.65	No	No	0	8	8
224	R:R:L137	R:R:Y314	9.38	No	Yes	0	8	9
225	R:R:C139	R:R:I169	3.27	No	No	0	5	6
226	R:R:I140	R:R:R144	6.26	No	No	4	9	9
227	R:R:I140	R:R:Y314	6.04	No	Yes	4	9	9
228	R:R:M227	R:R:S141	4.6	No	No	0	8	9
229	R:R:C230	R:R:S141	3.44	No	No	0	7	9
230	R:R:S141	R:R:Y231	13.99	No	Yes	0	9	9
231	R:R:C230	R:R:V142	3.42	No	No	0	7	6
232	R:R:D143	R:R:R159	9.53	No	No	0	8	3
233	R:R:R144	R:R:Y231	9.26	No	Yes	0	9	9
234	R:R:R144	R:R:Y314	6.17	No	Yes	4	9	9
235	R:R:L146	R:R:Y145	4.69	No	Yes	0	5	8
236	R:R:V149	R:R:Y145	7.57	Yes	Yes	6	7	8
237	R:R:H150	R:R:Y145	9.8	Yes	Yes	6	6	8
238	R:R:C230	R:R:Y145	6.72	No	Yes	0	7	8
239	R:R:F233	R:R:Y145	3.09	No	Yes	0	4	8
240	R:R:T234	R:R:Y145	3.75	Yes	Yes	6	8	8
241	R:R:L146	R:R:L155	2.77	No	No	0	5	4
242	R:R:A147	R:R:R159	6.91	No	No	0	8	3
243	R:R:I148	R:R:T234	4.56	No	Yes	0	8	8
244	R:R:I148	R:R:L238	2.85	No	No	0	8	8
245	R:R:H150	R:R:V149	5.54	Yes	Yes	6	6	7
246	R:R:T234	R:R:V149	3.17	Yes	Yes	6	8	7
247	R:R:T237	R:R:V149	6.35	No	Yes	0	5	7
248	R:R:H150	R:R:R153	5.64	Yes	No	0	6	5
249	R:R:H150	R:R:L155	5.14	Yes	No	0	6	4
250	R:R:Q157	R:R:T154	2.83	No	No	0	7	5
251	R:R:K158	R:R:L155	4.23	No	No	0	6	4
252	R:R:L161	R:R:Y160	5.86	No	No	0	4	5
253	R:R:L172	R:R:L176	6.92	No	No	0	4	4
254	R:R:L211	R:R:P179	8.21	No	No	0	4	8
255	R:R:R184	R:R:V180	6.54	Yes	No	0	5	4
256	R:R:F183	R:R:L182	4.87	No	No	0	5	4
257	R:R:F183	R:R:M200	13.68	No	No	0	5	5
258	R:R:C196	R:R:R184	2.79	No	Yes	0	9	5
259	R:R:E198	R:R:R184	19.77	No	Yes	0	5	5
260	R:R:R185	R:R:V187	3.92	No	No	1	4	3
261	R:R:D199	R:R:R185	19.06	No	No	1	4	4
262	R:R:T186	R:R:Y188	3.75	Yes	No	0	4	1
263	R:R:P194	R:R:Y188	11.13	No	No	0	5	1
264	R:R:N191	R:R:S190	5.96	No	No	0	2	2
265	R:R:P194	R:R:S193	3.56	No	No	0	5	3
266	R:R:R208	R:R:Y197	18.52	No	No	0	4	3
267	R:R:R278	R:R:Y197	3.09	Yes	No	0	4	3
268	R:R:E198	R:R:R208	10.47	No	No	0	5	4
269	R:R:M200	R:R:T204	3.01	No	No	0	5	3
270	R:R:M200	R:R:W207	6.98	No	No	0	5	3
271	R:R:N203	R:R:N206	10.9	No	No	0	4	1
272	R:R:L210	R:R:W207	3.42	No	No	0	2	3
273	R:R:M209	R:R:T275	7.53	No	No	0	3	4
274	R:R:M209	R:R:R278	3.72	No	Yes	0	3	4
275	R:R:L271	R:R:R212	10.93	Yes	Yes	0	6	5
276	R:R:D274	R:R:R212	10.72	Yes	Yes	2	4	5
277	R:R:R212	R:R:T275	6.47	Yes	No	0	5	4
278	R:R:I213	R:R:S217	6.19	No	No	0	4	4
279	R:R:N268	R:R:Q216	7.92	No	No	0	8	5
280	R:R:L271	R:R:Q216	5.32	Yes	No	0	6	5
281	R:R:F220	R:R:L224	3.65	Yes	Yes	3	8	7
282	R:R:F220	R:R:F260	4.29	Yes	Yes	3	8	9
283	R:R:F220	R:R:L265	3.65	Yes	No	0	8	6
284	R:R:F220	R:R:N268	15.71	Yes	No	0	8	8
285	R:R:I221	R:R:L225	2.85	No	No	0	4	3
286	R:R:P223	R:R:V222	3.53	No	No	0	9	5
287	R:R:I226	R:R:V222	3.07	No	No	0	6	5
288	R:R:L224	R:R:L228	4.15	Yes	No	0	7	4
289	R:R:F260	R:R:L224	4.87	Yes	Yes	3	9	7
290	R:R:L224	R:R:L261	4.15	Yes	No	0	7	6
291	R:R:F260	R:R:M227	11.2	Yes	No	0	9	8
292	R:R:F229	R:R:F233	7.5	No	No	0	4	4
293	R:R:I253	R:R:Y231	9.67	No	Yes	0	7	9
294	R:R:V256	R:R:Y231	3.79	Yes	Yes	0	8	9
295	R:R:V257	R:R:Y231	5.05	No	Yes	0	7	9
296	R:R:I253	R:R:T234	3.04	No	Yes	0	7	8
297	R:R:L235	R:R:M250	2.83	No	Yes	0	4	5
298	R:R:I253	R:R:L235	7.14	No	No	0	7	4
299	R:R:F254	R:R:L235	4.87	No	No	0	4	4
300	R:R:L238	R:R:M250	2.83	No	Yes	0	8	5
301	R:R:F239	R:R:M250	6.22	No	Yes	0	5	5
302	R:R:G244	R:R:Q245	3.29	No	No	0	4	4
303	R:R:H247	R:R:K246	7.86	No	No	0	5	7
304	R:R:K246	R:R:M250	5.76	No	Yes	0	7	5
305	R:R:R248	R:R:R322	3.2	No	No	0	7	8
306	R:R:I317	R:R:V252	7.68	No	No	0	6	7
307	R:R:I313	R:R:V256	3.07	No	Yes	4	7	8
308	R:R:V256	R:R:Y314	6.31	Yes	Yes	4	8	9
309	R:R:I259	R:R:L309	4.28	No	No	0	6	6
310	R:R:I259	R:R:I313	7.36	No	No	0	6	7
311	R:R:F260	R:R:W264	3.01	Yes	Yes	3	9	8
312	R:R:W264	R:R:Y267	2.89	Yes	Yes	0	8	7
313	R:R:H306	R:R:W264	7.41	No	Yes	0	9	8
314	R:R:L265	R:R:P266	3.28	No	No	0	6	9
315	R:R:L265	R:R:L269	5.54	No	No	0	6	6
316	R:R:L302	R:R:P266	3.28	No	No	0	7	9
317	R:R:L271	R:R:Y267	7.03	Yes	Yes	0	6	7
318	R:R:T299	R:R:Y267	4.99	No	Yes	0	6	7
319	R:R:E300	R:R:Y267	3.37	No	Yes	0	5	7
320	R:R:A295	R:R:V270	3.39	No	No	0	5	4
321	R:R:L296	R:R:V270	4.47	No	No	0	5	4
322	R:R:T299	R:R:V270	7.93	No	No	0	6	4
323	R:R:L271	R:R:L296	4.15	Yes	No	0	6	5
324	R:R:L272	R:R:L276	2.77	No	No	0	5	4
325	R:R:D274	R:R:R278	8.34	Yes	Yes	2	4	4
326	R:R:L276	R:R:V281	4.47	No	No	0	4	4
327	R:R:E284	R:R:M277	5.41	Yes	Yes	0	3	4
328	R:R:M277	R:R:R288	3.72	Yes	No	0	4	1
329	R:R:I292	R:R:M277	4.37	No	Yes	0	5	4
330	R:R:T279	R:R:V281	3.17	No	No	0	1	4
331	R:R:E284	R:R:Q280	11.47	Yes	No	0	3	2
332	R:R:Q283	R:R:T285	4.25	No	No	0	2	5
333	R:R:E284	R:R:R289	5.82	Yes	Yes	2	3	3
334	R:R:R288	R:R:T285	7.76	No	No	0	1	5
335	R:R:E287	R:R:H291	3.69	No	No	0	4	3
336	R:R:H291	R:R:N290	3.83	No	No	0	3	3
337	R:R:E300	R:R:I304	4.1	No	No	0	5	7
338	R:R:H306	R:R:S307	2.79	No	No	0	9	8
339	R:R:N310	R:R:P311	3.26	No	No	0	9	9
340	R:R:F316	R:R:L312	3.65	Yes	No	0	6	6
341	R:R:I313	R:R:Y314	3.63	No	Yes	4	7	9
342	R:R:A315	R:R:F316	2.77	No	Yes	0	7	6
343	R:R:A315	R:R:F321	8.32	No	No	0	7	8
344	R:R:L325	R:R:L326	4.15	No	No	0	6	4
345	R:R:I328	R:R:K327	2.91	No	No	0	5	4
346	R:R:L44	R:R:N47	2.75	No	No	0	2	4
347	L:L:I41	L:L:Q10	2.74	No	Yes	0	0	0
348	R:R:E300	R:R:K108	2.7	No	No	0	5	5
349	R:R:H323	R:R:K327	2.62	No	No	0	4	4
350	R:R:C263	R:R:W264	2.61	No	Yes	0	7	8
351	R:R:A93	R:R:W170	2.59	No	No	0	8	9
352	R:R:R159	R:R:T156	2.59	No	No	0	3	2
353	N:N:E39	N:N:Q37	2.55	Yes	No	0	0	0
354	R:R:F50	R:R:I46	2.51	No	No	0	5	5
355	R:R:F114	R:R:I103	2.51	Yes	No	0	6	6
356	R:R:L44	R:R:R294	2.43	No	No	0	2	2
357	R:R:I165	R:R:Y86	2.42	No	Yes	0	5	7
358	R:R:F97	R:R:N129	2.42	No	Yes	0	6	8
359	N:N:N46	N:N:R48	2.41	No	No	0	0	0
360	R:R:N203	R:R:W207	2.26	No	No	0	4	3
361	R:R:H247	R:R:R251	2.26	No	No	0	5	5
362	R:R:A37	R:R:P38	1.87	No	No	0	7	7
363	R:R:A138	R:R:P223	1.87	No	No	0	7	9
364	R:R:G133	R:R:S132	1.86	No	No	0	9	6
365	R:R:G324	R:R:V72	1.84	No	No	0	5	7
366	R:R:G201	R:R:T204	1.82	No	No	0	4	3
367	L:L:C51	R:R:A36	1.81	No	No	0	0	5
368	L:L:A36	R:R:A205	1.79	No	No	0	0	1
369	R:R:P41	R:R:V192	1.77	No	No	0	4	5
370	L:L:G17	L:L:I58	1.76	No	No	0	0	0
371	R:R:G318	R:R:I317	1.76	No	No	0	7	6
372	L:L:P33	R:R:T204	1.75	Yes	No	0	0	3
373	N:N:P54	N:N:T38	1.75	No	No	0	0	0
374	R:R:G244	R:R:M243	1.75	No	No	0	4	4
375	L:L:A1	R:R:S193	1.71	No	No	0	0	3
376	R:R:G171	R:R:L174	1.71	No	No	0	4	5
377	R:R:G303	R:R:L302	1.71	No	No	0	7	7
378	L:L:A4	R:R:V192	1.7	No	No	0	0	5
379	L:L:G47	L:L:N46	1.7	No	No	0	0	0
380	N:N:G47	N:N:N46	1.7	No	No	0	0	0
381	L:L:I41	R:R:P38	1.69	No	No	0	0	7
382	N:N:C51	N:N:T14	1.69	No	No	0	0	0
383	L:L:P54	N:N:L67	1.64	No	No	0	0	0
384	R:R:L178	R:R:P179	1.64	No	No	0	3	8
385	R:R:L214	R:R:P215	1.64	No	No	0	3	5
386	R:R:G318	R:R:Q319	1.64	No	No	0	7	5
387	R:R:N191	R:R:P41	1.63	No	No	0	2	4
388	R:R:S189	R:R:S190	1.63	No	No	0	1	2
389	R:R:S76	R:R:V78	1.62	No	No	0	4	5
390	R:R:A273	R:R:I292	1.62	No	No	0	5	5
391	R:R:A241	R:R:M243	1.61	No	No	0	3	4
392	R:R:V109	R:R:V52	1.6	No	No	0	4	5
393	R:R:V252	R:R:V256	1.6	No	Yes	0	7	8
394	R:R:C263	R:R:L305	1.59	No	No	0	7	5
395	R:R:G324	R:R:H323	1.59	No	No	0	5	4
396	L:L:Q24	N:N:P33	1.58	No	No	0	0	0
397	R:R:A177	R:R:L124	1.58	No	No	0	7	6
398	R:R:A249	R:R:L238	1.58	No	No	0	7	8
399	R:R:T275	R:R:T279	1.57	No	No	0	4	1
400	L:L:A36	R:R:N203	1.56	No	No	0	0	4
401	R:R:A205	R:R:N206	1.56	No	No	0	1	1
402	R:R:I165	R:R:S168	1.55	No	No	0	5	2
403	R:R:K320	R:R:S81	1.53	No	No	0	6	7
404	R:R:F130	R:R:G219	1.51	Yes	No	0	7	5
405	R:R:K120	R:R:T116	1.5	No	No	0	7	3
406	R:R:G318	R:R:R322	1.5	No	No	0	7	8
407	R:R:L325	R:R:V72	1.49	No	No	0	6	7
408	R:R:L174	R:R:V128	1.49	No	No	0	5	5
409	R:R:L87	R:R:T83	1.47	No	No	0	7	7
410	R:R:L99	R:R:T100	1.47	No	Yes	0	4	7
411	R:R:I282	R:R:M277	1.46	No	Yes	0	5	4
412	L:L:Q24	N:N:S30	1.44	No	No	0	0	0
413	R:R:Q216	R:R:S217	1.44	No	No	0	5	4
414	R:R:K246	R:R:M243	1.44	No	No	0	7	4
415	N:N:I18	N:N:L15	1.43	Yes	No	0	0	0
416	R:R:Q157	R:R:T156	1.42	No	No	0	7	2
417	R:R:E287	R:R:T285	1.41	No	No	0	4	5
418	L:L:K45	L:L:N22	1.4	No	No	0	0	0
419	R:R:D84	R:R:I73	1.4	No	No	0	8	6
420	R:R:L92	R:R:L96	1.38	No	No	0	6	7
421	R:R:L174	R:R:L175	1.38	No	No	0	5	4
422	R:R:L326	R:R:L329	1.38	No	No	0	4	6
423	R:R:F218	R:R:S217	1.32	No	No	0	4	4
424	R:R:E42	R:R:N290	1.31	No	No	0	4	3
425	R:R:R153	R:R:T152	1.29	No	No	0	5	5
426	R:R:S76	R:R:Y75	1.27	No	No	0	4	4
427	R:R:V52	R:R:Y49	1.26	No	No	0	5	2
428	R:R:F50	R:R:I53	1.26	No	No	0	5	5
429	R:R:F117	R:R:L118	1.22	No	No	0	1	6
430	R:R:K48	R:R:Y49	1.19	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E6	5.81833	6	2	0
2	L:L:R8	9.334	5	2	0
3	L:L:Q10	5.2975	4	0	0
4	L:L:K29	4.1425	4	1	0
5	L:L:P33	4.46143	7	1	0
6	L:L:H34	4.3475	4	1	0
7	L:L:E39	6.655	4	7	0
8	L:L:L44	5.7425	4	8	0
9	L:L:L52	5.21	4	0	0
10	L:L:N53	4.65	4	0	0
11	L:L:S56	4.38	4	0	0
12	L:L:K60	6.525	4	10	0
13	L:L:L67	5	4	0	0
14	N:N:I18	4.3375	4	0	0
15	N:N:E39	5.272	5	11	0
16	N:N:L52	4.8375	4	0	0
17	N:N:N53	5.3825	4	0	0
18	N:N:S56	4.7825	4	0	0
19	R:R:Y55	5.79	4	0	7
20	R:R:Y86	5.184	5	0	7
21	R:R:L90	5.1475	4	12	9
22	R:R:D94	7.515	4	12	9
23	R:R:T100	3.5925	4	13	7
24	R:R:W112	5.96	6	5	9
25	R:R:F114	3.485	4	0	6
26	R:R:N129	4.8025	4	0	8
27	R:R:F130	6.7725	4	3	7
28	R:R:Y131	8.83	4	0	7
29	R:R:I134	4.8275	4	3	8
30	R:R:Y145	5.93667	6	6	8
31	R:R:V149	5.6575	4	6	7
32	R:R:H150	6.53	4	6	6
33	R:R:R184	9.91	4	0	5
34	R:R:T186	4.1725	4	5	4
35	R:R:R212	7.9025	4	2	5
36	R:R:F220	6.825	4	3	8
37	R:R:L224	4.205	4	3	7
38	R:R:Y231	8.352	5	0	9
39	R:R:T234	3.63	4	6	8
40	R:R:M250	4.41	4	0	5
41	R:R:V256	3.6925	4	4	8
42	R:R:F260	5.428	5	3	9
43	R:R:W264	5.30167	6	3	8
44	R:R:Y267	4.57	4	0	7
45	R:R:L271	6.8575	4	0	6
46	R:R:D274	8.475	4	2	4
47	R:R:M277	3.74	4	0	4
48	R:R:R278	7.838	5	2	4
49	R:R:E284	6.67	4	2	3
50	R:R:R289	7.815	4	2	3
51	R:R:Y314	6.306	5	4	9
52	R:R:F316	4.415	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E6	R:R:R208	28.1191	10.47	Yes	No	0	0	4
2	R:R:E198	R:R:R208	29.062	10.47	No	No	0	5	4
3	R:R:E198	R:R:R184	29.2811	19.77	No	Yes	0	5	5
4	R:R:C196	R:R:R184	100	2.79	No	Yes	0	9	5
5	R:R:C196	R:R:W112	51.8484	7.84	No	Yes	5	9	9
6	R:R:T186	R:R:W112	48.4264	4.85	Yes	Yes	5	4	9
7	R:R:T186	R:R:Y188	93.2755	3.75	Yes	No	0	4	1
8	R:R:C119	R:R:C196	47.8969	7.28	No	No	5	9	9
9	R:R:C119	R:R:T186	47.5167	3.38	No	Yes	5	9	4
10	L:L:E6	L:L:R8	10.3514	4.65	Yes	Yes	2	0	0
11	L:L:E6	R:R:R212	39.5876	3.49	Yes	Yes	2	0	5
12	L:L:E6	R:R:R278	12.9455	6.98	Yes	Yes	2	0	4
13	R:R:R208	R:R:Y197	25.3912	18.52	No	No	0	4	3
14	R:R:R278	R:R:Y197	26.3791	3.09	Yes	No	0	4	3
15	L:L:H34	L:L:L7	48.7936	3.86	Yes	No	0	0	0
16	L:L:L7	R:R:Y197	49.7755	19.93	No	No	0	0	3
17	L:L:R8	R:R:R289	15.2222	10.66	Yes	Yes	2	0	3
18	L:L:K29	L:L:Q10	20.3594	4.07	Yes	Yes	0	0	0
19	L:L:H34	L:L:K29	28.6687	5.24	Yes	Yes	1	0	0
20	R:R:E284	R:R:R289	11.0396	5.82	Yes	Yes	2	3	3
21	L:L:N53	L:L:S56	11.0479	4.47	Yes	Yes	0	0	0
22	L:L:S56	L:L:V59	21.7322	4.85	Yes	No	0	0	0
23	L:L:I63	L:L:V59	36.3254	3.07	No	No	0	0	0
24	L:L:I63	L:L:L67	38.377	2.85	No	Yes	0	0	0
25	L:L:L67	N:N:V28	47.705	2.98	Yes	No	0	0	0
26	N:N:V28	N:N:V40	48.7107	6.41	No	No	0	0	0
27	N:N:L52	N:N:V40	49.7139	2.98	Yes	No	0	0	0
28	N:N:I18	N:N:L52	78.6184	4.28	Yes	Yes	0	0	0
29	N:N:I18	N:N:L44	84.2543	4.28	Yes	No	0	0	0
30	N:N:L44	N:N:N46	85.1699	8.24	No	No	0	0	0
31	N:N:G47	N:N:N46	86.9941	1.7	No	No	0	0	0
32	N:N:G47	R:R:Y188	87.8742	5.79	No	No	0	0	1
33	L:L:L52	L:L:V59	14.2734	8.94	Yes	No	0	0	0
34	L:L:H34	L:L:P33	18.2225	4.58	Yes	Yes	1	0	0
35	N:N:L52	N:N:V59	30.2465	8.94	Yes	No	0	0	0
36	N:N:S56	N:N:V59	29.1982	6.46	Yes	No	0	0	0
37	N:N:N53	N:N:S56	20.7266	4.47	Yes	Yes	0	0	0
38	N:N:N53	N:N:T14	11.0148	5.85	Yes	No	0	0	0
39	R:R:R184	R:R:V180	73.9514	6.54	Yes	No	0	5	4
40	R:R:E127	R:R:V180	73.9668	12.84	No	No	0	4	4
41	R:R:E127	R:R:Y131	74.0616	8.98	No	Yes	0	4	7
42	R:R:F130	R:R:Y131	74.4525	9.28	Yes	Yes	0	7	7
43	R:R:F130	R:R:W264	49.438	10.02	Yes	Yes	3	7	8
44	R:R:W264	R:R:Y267	49.4735	2.89	Yes	Yes	0	8	7
45	R:R:E300	R:R:Y267	18.1159	3.37	No	Yes	0	5	7
46	R:R:E300	R:R:I304	15.3371	4.1	No	No	0	5	7
47	R:R:I304	R:R:Y55	12.1258	8.46	No	Yes	0	7	7
48	R:R:L271	R:R:R212	57.1254	10.93	Yes	Yes	0	6	5
49	R:R:L271	R:R:Y267	51.6482	7.03	Yes	Yes	0	6	7
50	R:R:H306	R:R:W264	38.4765	7.41	No	Yes	0	9	8
51	R:R:H306	R:R:S307	27.9343	2.79	No	No	0	9	8
52	R:R:D94	R:R:S307	28.298	4.42	Yes	No	0	9	8
53	R:R:D94	R:R:N66	25.1578	6.73	Yes	No	0	9	9
54	R:R:A91	R:R:N66	20.7799	3.13	No	No	0	8	9
55	R:R:A91	R:R:V69	20.0443	3.39	No	No	0	8	8
56	R:R:F316	R:R:V69	19.3087	3.93	Yes	No	0	6	8
57	R:R:A315	R:R:F316	21.7938	2.77	No	Yes	0	7	6
58	R:R:A315	R:R:F321	19.0221	8.32	No	No	0	7	8
59	R:R:F321	R:R:V72	10.5789	5.24	No	No	0	8	7
60	R:R:F130	R:R:I134	25.5606	6.28	Yes	Yes	3	7	8
61	R:R:F260	R:R:I134	24.8913	3.77	Yes	Yes	3	9	8
62	R:R:F260	R:R:M227	70.8279	11.2	Yes	No	0	9	8
63	R:R:L137	R:R:M227	33.3179	5.65	No	No	0	8	8
64	R:R:L137	R:R:Y314	30.6445	9.38	No	Yes	0	8	9
65	R:R:I140	R:R:Y314	16.1271	6.04	No	Yes	4	9	9
66	R:R:I140	R:R:Y86	16.2527	6.04	No	Yes	0	9	7
67	R:R:F260	R:R:W264	50.8771	3.01	Yes	Yes	3	9	8
68	R:R:L137	R:R:L90	14.9663	5.54	No	Yes	0	8	9
69	R:R:D94	R:R:L90	10.3171	6.79	Yes	Yes	12	9	9
70	R:R:F97	R:R:H306	14.3575	9.05	No	No	0	6	9
71	R:R:M227	R:R:S141	43.7914	4.6	No	No	0	8	9
72	R:R:S141	R:R:Y231	25.7679	13.99	No	Yes	0	9	9
73	R:R:C230	R:R:S141	18.2154	3.44	No	No	0	7	9
74	R:R:C230	R:R:Y145	16.3368	6.72	No	Yes	0	7	8
75	R:R:I253	R:R:Y231	21.2253	9.67	No	Yes	0	7	9
76	R:R:I253	R:R:L235	15.1298	7.14	No	No	0	7	4
77	R:R:L235	R:R:M250	12.82	2.83	No	Yes	0	4	5
78	L:L:P33	R:R:T204	12.9621	1.75	Yes	No	0	0	3
79	R:R:M200	R:R:T204	10.8252	3.01	No	No	0	5	3
80	R:R:V252	R:R:V256	11.2078	1.6	No	Yes	0	7	8
81	R:R:D274	R:R:R212	17.7392	10.72	Yes	Yes	2	4	5
82	R:R:D274	R:R:R278	12.377	8.34	Yes	Yes	2	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S2	R:R:S43	6.52	0	No	No	0	5	0	1
L:L:V3	R:R:G111	3.68	0	No	No	0	4	0	1
L:L:V3	R:R:S193	3.23	0	No	No	0	3	0	1
L:L:E6	R:R:R208	10.47	2	Yes	No	0	4	0	1
L:L:E6	R:R:R212	3.49	2	Yes	Yes	0	5	0	1
L:L:E6	R:R:D274	6.5	2	Yes	Yes	0	4	0	1
L:L:E6	R:R:R278	6.98	2	Yes	Yes	0	4	0	1
L:L:L7	R:R:Y197	19.93	0	No	No	0	3	0	1
L:L:R8	R:R:D274	8.34	2	Yes	Yes	0	4	0	1
L:L:R8	R:R:R278	17.06	2	Yes	Yes	0	4	0	1
L:L:R8	R:R:R289	10.66	2	Yes	Yes	0	3	0	1
L:L:R8	R:R:D293	5.96	2	Yes	No	0	4	0	1
L:L:Q10	R:R:N191	10.56	0	Yes	No	0	2	0	1
L:L:L12	R:R:E284	3.98	2	No	Yes	0	3	0	1
L:L:L12	R:R:R289	3.64	2	No	Yes	0	3	0	1
L:L:L15	R:R:A36	4.73	0	No	No	0	5	0	1
L:L:P33	R:R:R185	2.88	1	Yes	No	0	4	0	1
L:L:P33	R:R:V187	3.53	1	Yes	No	0	3	0	1
L:L:P33	R:R:D199	11.27	1	Yes	No	0	4	0	1
L:L:K49	R:R:P38	3.35	0	No	No	0	7	0	1
L:L:K49	R:R:E40	5.4	0	No	No	0	4	0	1
N:N:G47	R:R:Y188	5.79	0	No	No	0	1	0	1
R:R:C39	R:R:R289	11.14	0	No	Yes	8	3	2	1
R:R:R185	R:R:V187	3.92	1	No	No	4	3	1	1
R:R:D199	R:R:R185	19.06	1	No	No	4	4	1	1
R:R:T186	R:R:Y188	3.75	5	Yes	No	4	1	2	1
R:R:P194	R:R:Y188	11.13	0	No	No	5	1	2	1
R:R:N191	R:R:S190	5.96	0	No	No	2	2	1	2
R:R:P194	R:R:S193	3.56	0	No	No	5	3	2	1
R:R:R208	R:R:Y197	18.52	0	No	No	4	3	1	1
R:R:R278	R:R:Y197	3.09	2	Yes	No	4	3	1	1
R:R:E198	R:R:R208	10.47	0	No	No	5	4	2	1
R:R:M200	R:R:T204	3.01	0	No	No	5	3	2	1
R:R:M200	R:R:W207	6.98	0	No	No	5	3	2	2
R:R:N203	R:R:N206	10.9	0	No	No	4	1	1	2
R:R:M209	R:R:T275	7.53	0	No	No	3	4	2	2
R:R:M209	R:R:R278	3.72	0	No	Yes	3	4	2	1
R:R:L271	R:R:R212	10.93	0	Yes	Yes	6	5	2	1
R:R:D274	R:R:R212	10.72	2	Yes	Yes	4	5	1	1
R:R:R212	R:R:T275	6.47	2	Yes	No	5	4	1	2
R:R:D274	R:R:R278	8.34	2	Yes	Yes	4	4	1	1
R:R:E284	R:R:M277	5.41	2	Yes	Yes	3	4	1	2
R:R:E284	R:R:Q280	11.47	2	Yes	No	3	2	1	2
R:R:E284	R:R:R289	5.82	2	Yes	Yes	3	3	1	1
R:R:N203	R:R:W207	2.26	0	No	No	4	3	1	2
R:R:A37	R:R:P38	1.87	0	No	No	7	7	2	1
R:R:G201	R:R:T204	1.82	0	No	No	4	3	2	1
L:L:C51	R:R:A36	1.81	0	No	No	0	5	0	1
L:L:A36	R:R:A205	1.79	0	No	No	0	1	0	1
R:R:P41	R:R:V192	1.77	0	No	No	4	5	2	1
L:L:P33	R:R:T204	1.75	1	Yes	No	0	3	0	1
L:L:A1	R:R:S193	1.71	0	No	No	0	3	0	1
L:L:A4	R:R:V192	1.7	0	No	No	0	5	0	1
L:L:I41	R:R:P38	1.69	0	No	No	0	7	0	1
R:R:N191	R:R:P41	1.63	0	No	No	2	4	1	2
L:L:A36	R:R:N203	1.56	0	No	No	0	4	0	1
R:R:A205	R:R:N206	1.56	0	No	No	1	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XWV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	394
Number of Links	430
Number of Hubs	52
Number of Links mediated by Hubs	186
Number of Communities	13
Number of Nodes involved in Communities	57
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	167684
Length Of Smallest Path	3
Average Path Length	19.8152
Length of Longest Path	43
Minimum Path Strength	1.225
Average Path Strength	6.15767
Maximum Path Strength	19.225
Minimum Path Correlation	0.7
Average Path Correlation	0.952392
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	50.2104
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3255
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • signaling receptor binding • enzyme regulator activity • enzyme activator activity • molecular function activator activity • molecular function regulator activity • catalytic activity • molecular transducer activity • signaling receptor activity • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • growth factor activity • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • immune response • immune system process • negative regulation of cell population proliferation • regulation of biological process • cell population proliferation • regulation of cellular process • regulation of cell population proliferation • negative regulation of cellular process
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • immune response • immune system process • negative regulation of cell population proliferation • regulation of biological process • cell population proliferation • regulation of cellular process • regulation of cell population proliferation • negative regulation of cellular process • biological regulation • negative regulation of biological process • cellular process • developmental process • multicellular organism development • multicellular organismal process • anatomical structure development • nervous system development • system development • defense response • response to stress • inflammatory response • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • intracellular signal transduction • cellular component organization • organelle organization • actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • membrane-bounded organelle • intracellular anatomical structure • tertiary granule lumen • membrane-enclosed lumen • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • tertiary granule • intracellular organelle • cellular anatomical structure • organelle lumen • cytoplasmic vesicle • organelle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • tertiary granule lumen • membrane-enclosed lumen • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle lumen • tertiary granule • intracellular organelle • cellular anatomical structure • organelle lumen • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • extracellular region • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen • specific granule lumen • specific granule • extracellular space • G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • protein binding • binding • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • developmental process • multicellular organismal process • head development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • midbrain development • anatomical structure development • system development • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • localization • import into cell • receptor internalization • transport • cellular process • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • response to stimulus • immune response • immune system process • defense response • response to stress • inflammatory response • acute inflammatory response to antigenic stimulus • acute inflammatory response • inflammatory response to antigenic stimulus • regulation of cellular process • homeostatic process • leukocyte apoptotic process • negative regulation of biological process • regulation of programmed cell death • regulation of neutrophil apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of neutrophil apoptotic process • negative regulation of cellular process • regulation of immune system process • myeloid cell homeostasis • regulation of leukocyte apoptotic process • myeloid cell apoptotic process • regulation of biological process • negative regulation of programmed cell death • regulation of apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • negative regulation of apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • homeostasis of number of cells • apoptotic process • programmed cell death • regulation of myeloid cell apoptotic process • neutrophil activation • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • cellular response to stimulus • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • taxis • granulocyte chemotaxis • response to chemical • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of response to stimulus • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • positive regulation of biological process • positive regulation of response to stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of cellular process • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • positive regulation of multicellular organismal process • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of vascular permeability • system process • circulatory system process • positive regulation of vascular permeability • vascular process in circulatory system • blood circulation • cellular defense response • epithelium development • kidney epithelium development • metanephric tubule morphogenesis • morphogenesis of an epithelium • metanephric epithelium development • tissue development • renal system development • tissue morphogenesis • metanephros development • metanephric tubule development • epithelial tube morphogenesis • kidney development • response to cytokine • cytokine-mediated signaling pathway • response to peptide • cellular response to interleukin-8 • response to interleukin-8 • cellular response to cytokine stimulus • interleukin-8-mediated signaling pathway • cell periphery • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • lytic vacuole • vacuole • mast cell granule • lysosome • mitotic spindle • cytoskeleton • spindle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • nucleus • nucleoplasm • nuclear lumen • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • organelle membrane • secretory granule membrane • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • regulation of blood circulation • heart contraction • behavior • locomotory behavior • secretion • export from cell • membrane docking • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • protein localization • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • negative regulation of secretion • cellular macromolecule localization • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • GABA-ergic synapse • glutamatergic synapse • cell body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Interleukin 8-like chemokines • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Interleukin 8-like chemokines • G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>8XWV_nogp_Chain_R D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	To be published
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	To be published
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	To be published
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	To be published
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	To be published
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	To be published
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	To be published
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	To be published
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	To be published
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	To be published
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	To be published
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	To be published
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	To be published
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	To be published
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	To be published
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	To be published
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	To be published
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	To be published
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	10.1038/s41586-020-2492-5

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XWV_nogp.zip

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