psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D9	A:A:L5	5.43	Yes	No	0	4	2
2	A:A:V13	B:B:N88	4.43	No	Yes	0	3	7
3	A:A:E14	A:A:K17	5.4	No	No	0	3	4
4	A:A:S16	B:B:N88	7.45	No	Yes	0	7	7
5	A:A:S16	B:B:K89	3.06	No	Yes	0	7	9
6	A:A:I19	B:B:K89	5.82	No	Yes	0	9	9
7	A:A:I19	B:B:A92	3.25	No	No	0	9	6
8	A:A:D20	B:B:K89	12.44	No	Yes	0	6	9
9	A:A:E25	A:A:R21	5.82	No	No	0	4	4
10	A:A:L23	B:B:K78	4.23	No	Yes	0	6	8
11	A:A:E28	A:A:R32	3.49	No	No	0	4	4
12	A:A:R32	R:R:T156	18.11	No	No	0	4	2
13	A:A:R32	R:R:R159	5.33	No	No	0	4	3
14	A:A:E33	A:A:H195	4.92	No	No	0	6	4
15	A:A:L194	A:A:V34	4.47	No	Yes	8	4	5
16	A:A:F196	A:A:V34	7.87	Yes	Yes	8	7	5
17	A:A:T219	A:A:V34	6.35	No	Yes	8	7	5
18	A:A:V339	A:A:V34	6.41	No	Yes	8	8	5
19	A:A:I343	A:A:V34	3.07	No	Yes	8	7	5
20	A:A:F199	A:A:K35	6.2	Yes	No	1	5	9
21	A:A:K35	B:B:W99	4.64	No	Yes	1	9	9
22	A:A:F196	A:A:L36	3.65	Yes	No	0	7	7
23	A:A:I222	A:A:L36	8.56	No	No	0	7	7
24	A:A:L37	A:A:L39	8.3	No	No	0	9	9
25	A:A:L37	A:A:V201	2.98	No	No	0	9	9
26	A:A:F215	A:A:L37	10.96	Yes	No	0	9	9
27	A:A:I49	A:A:L38	5.71	No	No	0	7	8
28	A:A:L38	A:A:M198	5.65	No	No	0	8	7
29	A:A:F223	A:A:L39	3.65	Yes	No	0	9	9
30	A:A:I253	A:A:L39	5.71	No	No	0	8	9
31	A:A:F223	A:A:G40	3.01	Yes	No	0	9	9
32	A:A:A41	A:A:E43	4.53	No	No	0	7	9
33	A:A:E43	A:A:R242	8.14	No	Yes	0	9	9
34	A:A:A226	A:A:S44	3.42	No	No	0	8	9
35	A:A:G45	A:A:T48	3.64	No	No	0	9	9
36	A:A:G45	A:A:N269	3.39	No	No	0	9	9
37	A:A:D200	A:A:K46	15.21	No	No	0	9	9
38	A:A:C224	A:A:I49	4.91	No	No	0	7	7
39	A:A:F267	A:A:I49	5.02	Yes	No	0	9	7
40	A:A:N331	A:A:Q52	17.17	No	No	0	8	9
41	A:A:I55	A:A:M53	4.37	No	No	0	8	8
42	A:A:I56	A:A:K54	5.82	No	No	0	7	7
43	A:A:T181	B:B:D118	4.34	No	No	0	9	9
44	A:A:T182	B:B:N119	5.85	No	No	0	7	9
45	A:A:G183	A:A:Q204	3.29	No	No	0	9	9
46	A:A:G183	B:B:N119	3.39	No	No	0	9	9
47	A:A:I184	A:A:V201	3.07	No	No	0	9	9
48	A:A:I184	B:B:W99	4.7	No	Yes	1	9	9
49	A:A:I184	B:B:L117	4.28	No	Yes	1	9	9
50	A:A:E186	A:A:H188	7.39	No	No	0	9	3
51	A:A:E186	A:A:F199	12.83	No	Yes	0	9	5
52	A:A:M198	A:A:T187	3.01	No	No	0	7	6
53	A:A:H188	A:A:H195	13.14	No	No	0	3	4
54	A:A:H188	A:A:K197	13.1	No	No	0	3	6
55	A:A:F189	A:A:F196	13.93	No	Yes	0	9	7
56	A:A:F189	A:A:M198	8.71	No	No	0	9	7
57	A:A:F191	A:A:K192	4.96	No	No	0	5	4
58	A:A:F191	A:A:F336	3.22	No	No	0	5	8
59	A:A:F196	A:A:L194	6.09	Yes	No	8	7	4
60	A:A:F196	A:A:V339	3.93	Yes	No	8	7	8
61	A:A:F199	A:A:K197	8.69	Yes	No	0	5	6
62	A:A:F199	A:A:F215	5.36	Yes	Yes	1	5	9
63	A:A:F199	B:B:W99	16.04	Yes	Yes	1	5	9
64	A:A:V201	A:A:W211	7.36	No	Yes	0	9	9
65	A:A:Q204	A:A:W211	10.95	No	Yes	0	9	9
66	A:A:Q204	B:B:Y145	5.64	No	Yes	0	9	8
67	A:A:S206	B:B:Y145	5.09	No	Yes	1	8	8
68	A:A:S206	B:B:D186	4.42	No	Yes	1	8	9
69	A:A:E207	A:A:K209	4.05	No	No	0	9	8
70	A:A:E207	B:B:D186	3.9	No	Yes	1	9	9
71	A:A:E207	B:B:C204	4.56	No	No	1	9	7
72	A:A:R208	A:A:W211	3	No	Yes	0	9	9
73	A:A:K209	B:B:D228	4.15	No	Yes	0	8	9
74	A:A:K210	B:B:Y145	3.58	Yes	Yes	1	9	8
75	A:A:K210	B:B:M188	12.96	Yes	No	1	9	8
76	A:A:K210	B:B:D228	8.3	Yes	Yes	1	9	9
77	A:A:K210	B:B:N230	4.2	Yes	No	1	9	9
78	A:A:I212	A:A:W211	3.52	No	Yes	0	8	9
79	A:A:F215	A:A:W211	4.01	Yes	Yes	0	9	9
80	A:A:W211	B:B:L117	5.69	Yes	Yes	0	9	9
81	A:A:F259	A:A:I212	5.02	No	No	0	9	8
82	A:A:H213	A:A:W258	7.41	No	Yes	0	8	5
83	A:A:H213	B:B:Y59	7.62	No	Yes	0	8	8
84	A:A:H213	B:B:W332	8.46	No	Yes	0	8	9
85	A:A:C214	B:B:Y59	5.38	Yes	Yes	1	7	8
86	A:A:C214	B:B:Q75	9.16	Yes	No	1	7	9
87	A:A:C214	B:B:M101	3.24	Yes	No	0	7	9
88	A:A:C214	B:B:L117	3.17	Yes	Yes	1	7	9
89	A:A:F215	B:B:W99	8.02	Yes	Yes	1	9	9
90	A:A:E216	A:A:W258	7.63	No	Yes	0	7	5
91	A:A:I343	A:A:T219	3.04	No	No	8	7	7
92	A:A:A220	A:A:I265	3.25	No	Yes	0	8	8
93	A:A:F259	A:A:I221	8.79	No	No	23	9	8
94	A:A:I221	A:A:T262	3.04	No	No	23	8	7
95	A:A:F267	A:A:I222	3.77	Yes	No	0	9	7
96	A:A:I222	A:A:V335	3.07	No	No	0	7	8
97	A:A:F223	A:A:L249	3.65	Yes	No	0	9	9
98	A:A:F223	A:A:F250	11.79	Yes	Yes	0	9	9
99	A:A:M243	A:A:V225	3.04	No	Yes	0	8	7
100	A:A:S246	A:A:V225	4.85	No	Yes	0	9	7
101	A:A:L268	A:A:V225	2.98	Yes	Yes	0	8	7
102	A:A:F307	A:A:V225	5.24	Yes	Yes	0	8	7
103	A:A:A226	A:A:D229	3.09	No	No	0	8	8
104	A:A:A226	A:A:K270	6.42	No	No	0	8	9
105	A:A:F274	A:A:L227	18.27	No	No	0	9	7
106	A:A:L273	A:A:S228	6.01	No	No	0	6	9
107	A:A:K277	A:A:S228	9.18	No	No	0	9	9
108	A:A:D229	A:A:L232	4.07	No	No	21	8	8
109	A:A:D229	A:A:R242	8.34	No	Yes	21	8	9
110	A:A:D231	A:A:Y230	21.84	No	Yes	13	9	8
111	A:A:F274	A:A:Y230	6.19	No	Yes	13	9	8
112	A:A:K277	A:A:Y230	7.17	No	Yes	13	9	8
113	A:A:I278	A:A:Y230	6.04	No	Yes	13	6	8
114	A:A:D231	A:A:K277	8.3	No	No	13	9	9
115	A:A:L232	A:A:R242	7.29	No	Yes	21	8	9
116	A:A:N241	A:A:V233	2.96	No	No	0	9	5
117	A:A:E236	A:A:L234	13.25	No	No	0	9	8
118	A:A:L234	A:A:R242	9.72	No	Yes	0	8	9
119	A:A:D237	A:A:E238	6.5	No	No	0	8	4
120	A:A:D237	A:A:E239	5.2	No	No	0	8	4
121	A:A:C286	A:A:M243	3.24	No	No	12	6	8
122	A:A:M243	A:A:Y287	4.79	No	Yes	12	8	7
123	A:A:H244	A:A:M247	5.25	No	Yes	0	4	6
124	A:A:C286	A:A:H244	5.9	No	No	0	6	4
125	A:A:M247	A:A:Y287	5.99	Yes	Yes	0	6	7
126	A:A:F307	A:A:M247	4.98	Yes	Yes	0	8	6
127	A:A:L310	A:A:M247	4.24	No	Yes	0	4	6
128	A:A:C254	A:A:F250	6.98	Yes	Yes	18	5	9
129	A:A:F250	A:A:I264	3.77	Yes	No	18	9	6
130	A:A:F250	A:A:F307	8.57	Yes	Yes	0	9	8
131	A:A:F250	A:A:L310	4.87	Yes	No	0	9	4
132	A:A:D251	A:A:N255	9.42	No	No	0	5	8
133	A:A:C254	A:A:N255	3.15	Yes	No	0	5	8
134	A:A:C254	A:A:I264	3.27	Yes	No	18	5	6
135	A:A:C254	A:A:K317	6.47	Yes	No	18	5	7
136	A:A:K312	A:A:N255	6.99	No	No	0	5	8
137	A:A:N256	A:A:W258	3.39	No	Yes	0	8	5
138	A:A:K257	A:A:W258	12.76	No	Yes	0	4	5
139	A:A:W258	B:B:R314	4	Yes	No	0	5	8
140	A:A:F259	A:A:T262	5.19	No	No	23	9	7
141	A:A:R313	A:A:T260	5.17	No	No	0	4	3
142	A:A:D261	A:A:T262	5.78	No	No	0	4	7
143	A:A:D261	A:A:K349	4.15	No	No	0	4	5
144	A:A:S263	A:A:Y320	8.9	No	Yes	0	7	7
145	A:A:S263	A:A:V342	6.46	No	No	0	7	7
146	A:A:I264	A:A:K317	5.82	No	No	18	6	7
147	A:A:F267	A:A:I265	3.77	Yes	Yes	22	9	8
148	A:A:F334	A:A:I265	3.77	No	Yes	22	3	8
149	A:A:A338	A:A:I265	4.87	No	Yes	0	6	8
150	A:A:L266	A:A:L268	4.15	No	Yes	0	9	8
151	A:A:F307	A:A:L266	3.65	Yes	No	0	8	9
152	A:A:F267	A:A:F334	5.36	Yes	No	22	9	3
153	A:A:L268	A:A:T321	2.95	Yes	No	0	8	5
154	A:A:F323	A:A:L268	4.87	Yes	Yes	0	4	8
155	A:A:K271	A:A:Y296	7.17	No	Yes	0	5	4
156	A:A:C325	A:A:K271	4.85	No	No	0	7	5
157	A:A:D272	A:A:E275	6.5	No	No	0	9	5
158	A:A:E276	A:A:L273	5.3	No	No	0	5	6
159	A:A:F274	A:A:I278	7.54	No	No	13	9	6
160	A:A:E275	A:A:E276	6.34	No	No	0	5	5
161	A:A:E275	A:A:Y296	3.37	No	Yes	0	5	4
162	A:A:P282	A:A:S281	3.56	No	No	0	5	7
163	A:A:L283	A:A:Y287	3.52	No	Yes	0	7	7
164	A:A:C286	A:A:Y287	9.41	No	Yes	12	6	7
165	A:A:Y287	A:A:Y302	10.92	Yes	Yes	12	7	6
166	A:A:Q306	A:A:Y287	13.53	No	Yes	12	5	7
167	A:A:G292	A:A:Y290	5.79	No	Yes	0	7	7
168	A:A:Y290	A:A:Y302	10.92	Yes	Yes	0	7	6
169	A:A:E298	A:A:S293	8.62	No	No	0	4	3
170	A:A:E297	A:A:T295	4.23	No	No	0	4	5
171	A:A:E298	A:A:T295	9.88	No	No	0	4	5
172	A:A:E297	A:A:Y296	8.98	No	Yes	0	4	4
173	A:A:F323	A:A:Y296	3.09	Yes	Yes	0	4	4
174	A:A:A300	A:A:F323	4.16	No	Yes	0	5	4
175	A:A:Q306	A:A:Y302	6.76	No	Yes	12	5	6
176	A:A:Q304	A:A:T321	7.09	No	No	0	5	5
177	A:A:F323	A:A:Q304	11.71	Yes	No	0	4	5
178	A:A:K314	A:A:N311	5.6	No	No	0	3	8
179	A:A:E318	A:A:Y320	7.86	No	Yes	0	4	7
180	A:A:A338	A:A:Y320	5.34	No	Yes	0	6	7
181	A:A:D341	A:A:Y320	13.79	No	Yes	24	8	7
182	A:A:Y320	R:R:H242	4.36	Yes	No	24	7	5
183	A:A:F334	A:A:H322	22.63	No	No	0	3	9
184	A:A:D328	A:A:T324	4.34	No	No	0	9	9
185	A:A:N331	A:A:T324	7.31	No	No	0	8	9
186	A:A:C325	A:A:D328	6.22	No	No	0	7	9
187	A:A:D328	A:A:K330	4.15	No	No	0	9	4
188	A:A:N331	A:A:V332	2.96	No	No	0	8	7
189	A:A:D337	A:A:Q333	10.44	No	No	0	4	5
190	A:A:F336	A:A:T340	6.49	No	No	0	8	6
191	A:A:D341	R:R:H242	3.78	No	No	24	8	5
192	A:A:D341	R:R:M243	8.32	No	Yes	0	8	4
193	A:A:I344	R:R:I148	4.42	No	Yes	0	6	8
194	A:A:K345	R:R:M243	5.76	No	Yes	0	5	4
195	A:A:N347	R:R:A147	3.13	No	No	0	8	8
196	A:A:L348	A:A:L353	4.15	Yes	Yes	25	9	7
197	A:A:F354	A:A:L348	3.65	No	Yes	0	5	9
198	A:A:F354	A:A:K349	4.96	No	No	0	5	5
199	A:A:C351	R:R:T83	5.07	No	No	0	4	7
200	A:A:C351	R:R:R144	9.75	No	Yes	0	4	9
201	A:A:L353	R:R:R144	13.36	Yes	Yes	0	7	9
202	A:A:L353	R:R:V252	2.98	Yes	No	0	7	7
203	A:A:L353	R:R:I253	4.28	Yes	No	0	7	7
204	A:A:F354	R:R:Q245	7.03	No	No	0	5	4
205	B:B:D5	B:B:L4	4.07	No	No	0	1	4
206	B:B:L4	G:G:I9	5.71	No	No	0	4	2
207	B:B:D5	B:B:R8	8.34	No	No	0	1	3
208	B:B:L14	G:G:L19	4.15	Yes	Yes	0	8	9
209	B:B:I18	B:B:K15	7.27	No	No	0	7	6
210	B:B:N16	B:B:R19	8.44	No	No	0	1	4
211	B:B:A21	G:G:R27	5.53	No	Yes	0	4	8
212	B:B:D258	B:B:R22	17.87	No	No	0	7	6
213	B:B:Q259	B:B:R22	5.84	Yes	No	0	6	6
214	B:B:A26	B:B:Q259	4.55	No	Yes	0	3	6
215	B:B:D27	G:G:S31	7.36	No	No	0	8	9
216	B:B:L30	B:B:T34	2.95	Yes	No	0	5	5
217	B:B:L30	B:B:M262	7.07	Yes	Yes	0	5	4
218	B:B:M262	B:B:S31	3.07	Yes	No	0	4	1
219	B:B:I37	B:B:T34	6.08	Yes	No	0	2	5
220	B:B:T34	G:G:M38	3.01	No	No	0	5	4
221	B:B:N35	B:B:N36	5.45	No	No	0	1	1
222	B:B:I37	B:B:R283	6.26	Yes	Yes	0	2	9
223	B:B:I37	B:B:K301	5.82	Yes	No	0	2	5
224	B:B:I43	B:B:V40	3.07	No	No	0	3	3
225	B:B:D298	B:B:V40	4.38	No	No	0	9	3
226	B:B:A305	B:B:I43	3.25	No	No	0	4	3
227	B:B:L308	B:B:M45	4.24	No	No	0	7	4
228	B:B:R46	B:B:R48	3.2	No	No	0	5	7
229	B:B:K337	B:B:T47	9.01	Yes	No	14	6	3
230	B:B:T47	B:B:W339	8.49	No	Yes	14	3	9
231	B:B:N340	B:B:R48	7.23	No	No	9	9	7
232	B:B:R48	G:G:F61	5.34	No	Yes	9	7	8
233	B:B:I338	B:B:R49	5.01	No	No	0	5	7
234	B:B:R49	G:G:F61	11.76	No	Yes	0	7	8
235	B:B:R52	B:B:T50	9.06	No	No	0	7	3
236	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
237	B:B:L51	B:B:W82	21.64	Yes	Yes	0	9	9
238	B:B:L51	B:B:T87	4.42	Yes	No	0	9	5
239	B:B:L336	B:B:L51	5.54	No	Yes	0	7	9
240	B:B:I338	B:B:L51	7.14	No	Yes	0	5	9
241	B:B:F335	B:B:R52	7.48	No	No	0	4	7
242	B:B:H54	B:B:I58	7.95	Yes	Yes	7	9	9
243	B:B:H54	B:B:S72	9.76	Yes	No	7	9	9
244	B:B:H54	B:B:S74	13.95	Yes	No	7	9	9
245	B:B:H54	B:B:I80	13.26	Yes	No	7	9	8
246	B:B:H54	B:B:W82	6.35	Yes	Yes	7	9	9
247	B:B:A56	B:B:D76	4.63	No	No	0	7	9
248	B:B:K57	B:B:Y59	8.36	No	Yes	0	9	8
249	B:B:K57	B:B:W332	15.08	No	Yes	0	9	9
250	B:B:I58	B:B:S74	3.1	Yes	No	7	9	9
251	B:B:G330	B:B:I58	3.53	No	Yes	0	5	9
252	B:B:I58	B:B:L336	5.71	Yes	No	0	9	7
253	B:B:Q75	B:B:Y59	21.42	No	Yes	1	9	8
254	B:B:A60	B:B:T102	3.36	No	No	0	7	8
255	B:B:M61	B:B:W63	4.65	No	Yes	10	6	7
256	B:B:C317	B:B:M61	6.48	No	No	0	7	6
257	B:B:A328	B:B:M61	3.22	No	No	10	5	6
258	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
259	B:B:H62	B:B:R150	12.41	No	Yes	0	6	6
260	B:B:L70	B:B:W63	10.25	No	Yes	0	5	7
261	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
262	B:B:T321	B:B:W63	12.13	No	Yes	10	7	7
263	B:B:A328	B:B:W63	5.19	No	Yes	10	5	7
264	B:B:G64	B:B:Y105	5.79	No	Yes	0	5	6
265	B:B:S67	B:B:T321	3.2	No	No	10	5	7
266	B:B:D323	B:B:S67	10.31	No	No	10	7	5
267	B:B:D83	B:B:R68	13.1	No	No	0	8	5
268	B:B:R68	B:B:Y85	25.72	No	No	0	5	4
269	B:B:D83	B:B:L69	4.07	No	No	0	8	5
270	B:B:L69	B:B:Y105	5.86	No	Yes	0	5	6
271	B:B:L70	B:B:W82	4.56	No	Yes	0	5	9
272	B:B:L79	B:B:V71	2.98	Yes	Yes	3	7	8
273	B:B:I81	B:B:V71	3.07	Yes	Yes	3	7	8
274	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
275	B:B:V71	B:B:Y105	6.31	Yes	Yes	3	8	6
276	B:B:V112	B:B:V71	3.21	No	Yes	3	8	8
277	B:B:S72	B:B:W82	6.18	No	Yes	7	9	9
278	B:B:L336	B:B:S72	4.5	No	No	0	7	9
279	B:B:A73	B:B:L79	3.15	No	Yes	0	9	7
280	B:B:A73	B:B:C103	3.61	No	No	0	9	8
281	B:B:D76	B:B:S74	7.36	No	No	0	9	9
282	B:B:Q75	B:B:W99	9.86	No	Yes	1	9	9
283	B:B:D76	B:B:K78	8.3	No	Yes	0	9	8
284	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
285	B:B:G77	B:B:S98	3.71	No	No	0	8	8
286	B:B:K78	B:B:P94	5.02	Yes	No	0	8	5
287	B:B:I93	B:B:L79	4.28	Yes	Yes	3	7	7
288	B:B:L79	B:B:L95	6.92	Yes	Yes	3	7	8
289	B:B:L79	B:B:V112	2.98	Yes	No	3	7	8
290	B:B:I80	B:B:W82	8.22	No	Yes	7	8	9
291	B:B:I80	B:B:K89	4.36	No	Yes	7	8	9
292	B:B:I81	B:B:V90	3.07	Yes	No	3	7	5
293	B:B:H91	B:B:I81	6.63	Yes	Yes	3	5	7
294	B:B:I81	B:B:Y105	3.63	Yes	Yes	3	7	6
295	B:B:I81	B:B:L126	4.28	Yes	Yes	3	7	5
296	B:B:K89	B:B:W82	12.76	Yes	Yes	7	9	9
297	B:B:D83	B:B:N88	5.39	No	Yes	0	8	7
298	B:B:S84	G:G:F61	3.96	No	Yes	0	5	8
299	B:B:Y85	G:G:P60	11.13	No	Yes	9	4	9
300	B:B:Y85	G:G:F61	5.16	No	Yes	9	4	8
301	B:B:N88	B:B:T86	10.24	Yes	No	0	7	6
302	B:B:H91	B:B:V90	5.54	Yes	No	3	5	5
303	B:B:H91	B:B:V133	5.54	Yes	Yes	3	5	4
304	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
305	B:B:I93	B:B:Y124	7.25	Yes	Yes	3	7	6
306	B:B:I93	B:B:V133	10.75	Yes	Yes	3	7	4
307	B:B:L95	B:B:V100	5.96	Yes	No	3	8	9
308	B:B:C114	B:B:L95	3.17	Yes	Yes	3	8	8
309	B:B:L95	B:B:Y124	5.86	Yes	Yes	3	8	6
310	B:B:R96	B:B:V135	5.23	No	No	0	6	4
311	B:B:E138	B:B:R96	9.3	No	No	0	6	6
312	B:B:D118	B:B:S97	10.31	No	No	0	9	8
313	B:B:L117	B:B:W99	4.56	Yes	Yes	1	9	9
314	B:B:C114	B:B:V100	5.12	Yes	No	3	8	9
315	B:B:M101	B:B:Y145	3.59	No	Yes	0	9	8
316	B:B:L126	B:B:Y105	3.52	Yes	Yes	3	5	6
317	B:B:D154	B:B:P107	3.22	Yes	No	0	6	6
318	B:B:N110	B:B:S108	5.96	Yes	No	19	4	6
319	B:B:D154	B:B:S108	8.83	Yes	No	19	6	6
320	B:B:N110	B:B:Y111	3.49	Yes	Yes	19	4	4
321	B:B:K127	B:B:N110	5.6	No	Yes	0	4	4
322	B:B:D154	B:B:N110	4.04	Yes	Yes	19	6	4
323	B:B:I123	B:B:Y111	4.84	Yes	Yes	0	6	4
324	B:B:N125	B:B:Y111	9.3	No	Yes	0	4	4
325	B:B:D154	B:B:Y111	6.9	Yes	Yes	19	6	4
326	B:B:L126	B:B:V112	5.96	Yes	No	3	5	8
327	B:B:C114	B:B:G115	3.92	Yes	No	0	8	9
328	B:B:C114	B:B:S122	5.16	Yes	No	0	8	8
329	B:B:L117	B:B:Y145	3.52	Yes	Yes	1	9	8
330	B:B:E138	B:B:I120	8.2	No	No	0	6	6
331	B:B:A140	B:B:I120	3.25	No	No	0	5	6
332	B:B:C121	B:B:C149	3.64	No	Yes	1	8	8
333	B:B:C121	B:B:T159	3.38	No	Yes	1	8	9
334	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
335	B:B:E138	B:B:S122	4.31	No	No	0	6	8
336	B:B:I123	B:B:S136	3.1	Yes	No	0	6	4
337	B:B:I123	B:B:L139	4.28	Yes	No	0	6	9
338	B:B:I123	B:B:I171	5.89	Yes	No	0	6	6
339	B:B:V133	B:B:Y124	3.79	Yes	Yes	3	4	6
340	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
341	B:B:L126	B:B:V133	2.98	Yes	Yes	3	5	4
342	B:B:R134	B:B:T128	10.35	No	No	0	3	3
343	B:B:L139	B:B:R137	3.64	No	No	0	9	5
344	B:B:L139	B:B:W169	14.81	No	Yes	0	9	8
345	B:B:H142	B:B:T159	5.48	Yes	Yes	1	9	9
346	B:B:H142	B:B:S161	15.34	Yes	Yes	1	9	9
347	B:B:D163	B:B:H142	3.78	Yes	Yes	1	9	9
348	B:B:H142	B:B:W169	3.17	Yes	Yes	1	9	8
349	B:B:D163	B:B:T143	8.67	Yes	No	0	9	5
350	B:B:D163	B:B:G144	5.03	Yes	No	0	9	8
351	B:B:G162	B:B:Y145	5.79	No	Yes	1	9	8
352	B:B:D186	B:B:Y145	5.75	Yes	Yes	1	9	8
353	B:B:M188	B:B:Y145	3.59	No	Yes	1	8	8
354	B:B:C149	B:B:L146	3.17	Yes	No	1	8	7
355	B:B:L146	B:B:T159	2.95	No	Yes	1	7	9
356	B:B:S147	B:B:S160	4.89	No	No	0	9	6
357	B:B:C148	B:B:R150	6.96	No	Yes	0	6	6
358	B:B:C149	B:B:I157	3.27	Yes	Yes	1	8	7
359	B:B:C149	B:B:T159	3.38	Yes	Yes	1	8	9
360	B:B:F151	B:B:I157	7.54	No	Yes	0	9	7
361	B:B:L152	B:B:Q156	7.99	Yes	Yes	0	3	5
362	B:B:L152	B:B:V158	4.47	Yes	Yes	2	3	5
363	B:B:L152	B:B:L192	6.92	Yes	No	2	3	5
364	B:B:L152	B:B:T196	4.42	Yes	No	0	3	1
365	B:B:D153	B:B:Q156	5.22	No	Yes	0	5	5
366	B:B:E172	B:B:N155	7.89	No	No	0	6	3
367	B:B:L168	B:B:Q156	5.32	Yes	Yes	0	6	5
368	B:B:I157	B:B:T159	3.04	Yes	Yes	1	7	9
369	B:B:I157	B:B:W169	3.52	Yes	Yes	1	7	8
370	B:B:L168	B:B:V158	2.98	Yes	Yes	2	6	5
371	B:B:L190	B:B:V158	4.47	Yes	Yes	2	5	5
372	B:B:L192	B:B:V158	2.98	No	Yes	2	5	5
373	B:B:F199	B:B:V158	7.87	Yes	Yes	2	9	5
374	B:B:T159	B:B:W169	8.49	Yes	Yes	1	9	8
375	B:B:S160	B:B:V187	8.08	No	Yes	0	6	9
376	B:B:L190	B:B:S160	3	Yes	No	0	5	6
377	B:B:G162	B:B:S161	3.71	No	Yes	1	9	9
378	B:B:D163	B:B:S161	7.36	Yes	Yes	1	9	9
379	B:B:S161	B:B:T165	4.8	Yes	Yes	1	9	7
380	B:B:D186	B:B:G162	3.35	Yes	No	1	9	9
381	B:B:D163	B:B:T165	10.12	Yes	Yes	1	9	7
382	B:B:T165	B:B:T179	3.14	Yes	No	0	7	4
383	B:B:C166	B:B:F180	4.19	Yes	Yes	2	8	7
384	B:B:C166	B:B:V187	5.12	Yes	Yes	2	8	9
385	B:B:C166	B:B:F199	5.59	Yes	Yes	2	8	9
386	B:B:C166	B:B:S201	3.44	Yes	Yes	2	8	9
387	B:B:A167	B:B:W169	3.89	No	Yes	1	4	8
388	B:B:A167	B:B:Q176	4.55	No	No	1	4	4
389	B:B:L168	B:B:T177	7.37	Yes	No	2	6	4
390	B:B:L168	B:B:T178	2.95	Yes	No	2	6	4
391	B:B:F180	B:B:L168	4.87	Yes	Yes	2	7	6
392	B:B:Q176	B:B:W169	16.43	No	Yes	1	4	8
393	B:B:D170	B:B:T173	4.34	No	No	0	9	5
394	B:B:D170	B:B:T177	4.34	No	No	0	9	4
395	B:B:Q176	B:B:T179	5.67	No	No	0	4	4
396	B:B:T177	B:B:T178	4.71	No	No	2	4	4
397	B:B:F180	B:B:T178	9.08	Yes	No	2	7	4
398	B:B:F180	B:B:F199	8.57	Yes	Yes	2	7	9
399	B:B:F180	B:B:W211	12.03	Yes	Yes	2	7	8
400	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
401	B:B:G182	B:B:T181	3.64	No	No	0	6	2
402	B:B:H183	B:B:V187	5.54	Yes	Yes	2	9	9
403	B:B:H183	B:B:S201	5.58	Yes	Yes	2	9	9
404	B:B:A203	B:B:H183	8.78	No	Yes	0	8	9
405	B:B:H183	B:B:K209	14.41	Yes	Yes	2	9	6
406	B:B:H183	B:B:W211	4.23	Yes	Yes	2	9	8
407	B:B:G185	B:B:T184	3.64	No	No	0	5	3
408	B:B:D205	B:B:T184	8.67	No	No	0	9	3
409	B:B:C204	B:B:D186	4.67	No	Yes	1	7	9
410	B:B:S201	B:B:V187	3.23	Yes	Yes	2	9	9
411	B:B:M188	B:B:N230	4.21	No	No	1	8	9
412	B:B:I232	B:B:S189	4.64	Yes	No	0	8	7
413	B:B:F199	B:B:L190	9.74	Yes	Yes	2	9	5
414	B:B:I232	B:B:S191	4.64	Yes	No	0	8	8
415	B:B:F234	B:B:S191	3.96	Yes	No	0	5	8
416	B:B:A193	B:B:F234	4.16	No	Yes	0	4	5
417	B:B:D195	B:B:R197	4.76	No	No	0	5	5
418	B:B:R197	B:B:R214	7.46	No	No	0	5	9
419	B:B:L198	B:B:L210	8.3	No	No	0	3	5
420	B:B:L198	B:B:R219	4.86	No	No	0	3	5
421	B:B:F199	B:B:W211	12.03	Yes	Yes	2	9	8
422	B:B:L210	B:B:V200	2.98	No	Yes	0	5	6
423	B:B:I232	B:B:V200	6.14	Yes	Yes	4	8	6
424	B:B:F234	B:B:V200	10.49	Yes	Yes	4	5	6
425	B:B:F241	B:B:V200	11.8	Yes	Yes	4	6	6
426	B:B:S201	B:B:W211	7.41	Yes	Yes	2	9	8
427	B:B:G202	B:B:I229	3.53	No	No	0	6	7
428	B:B:A203	B:B:D205	3.09	No	No	0	8	9
429	B:B:C204	B:B:D228	6.22	No	Yes	1	7	9
430	B:B:D205	B:B:S207	4.42	No	No	0	9	5
431	B:B:K209	B:B:S207	3.06	Yes	No	0	6	5
432	B:B:K209	B:B:W211	5.8	Yes	Yes	2	6	8
433	B:B:C218	B:B:K209	6.47	Yes	Yes	2	5	6
434	B:B:K209	B:B:T221	9.01	Yes	No	0	6	7
435	B:B:L210	B:B:L255	11.07	No	No	0	5	6
436	B:B:C218	B:B:W211	5.22	Yes	Yes	2	5	8
437	B:B:D212	B:B:E215	9.09	No	No	0	9	3
438	B:B:D212	B:B:R219	9.53	No	No	0	9	5
439	B:B:R214	B:B:V213	3.92	No	No	0	9	4
440	B:B:M217	G:G:M21	5.78	No	No	0	3	1
441	B:B:C218	G:G:Q18	3.05	Yes	No	2	5	9
442	B:B:C218	G:G:E22	3.04	Yes	No	2	5	9
443	B:B:F222	B:B:Q220	9.37	No	No	0	8	7
444	B:B:Q220	G:G:I25	5.49	No	No	0	7	2
445	B:B:F222	B:B:F241	8.57	No	Yes	4	8	6
446	B:B:F222	B:B:F253	5.36	No	Yes	4	8	6
447	B:B:H225	B:B:I229	5.3	Yes	No	4	9	7
448	B:B:H225	B:B:T243	6.85	Yes	Yes	4	9	8
449	B:B:H225	B:B:S245	13.95	Yes	No	0	9	9
450	B:B:D247	B:B:H225	3.78	Yes	Yes	0	9	9
451	B:B:H225	B:B:R251	19.18	Yes	Yes	4	9	8
452	B:B:F253	B:B:H225	3.39	Yes	Yes	4	6	9
453	B:B:D247	B:B:E226	5.2	Yes	No	0	9	3
454	B:B:D228	B:B:S227	7.36	Yes	No	1	9	6
455	B:B:D246	B:B:S227	4.42	No	No	1	9	6
456	B:B:D247	B:B:S227	5.89	Yes	No	0	9	6
457	B:B:D228	B:B:D246	10.65	Yes	No	1	9	9
458	B:B:I229	B:B:T243	6.08	No	Yes	4	7	8
459	B:B:D246	B:B:N230	6.73	No	No	1	9	9
460	B:B:A231	B:B:V276	3.39	No	No	0	5	6
461	B:B:F241	B:B:I232	5.02	Yes	Yes	4	6	8
462	B:B:I232	B:B:T243	3.04	Yes	Yes	4	8	8
463	B:B:F234	B:B:G238	3.01	Yes	No	0	5	7
464	B:B:F234	B:B:F241	3.22	Yes	Yes	4	5	6
465	B:B:F235	B:B:P236	7.22	Yes	No	15	6	7
466	B:B:F235	B:B:N237	7.25	Yes	No	15	6	5
467	B:B:A240	B:B:F235	4.16	No	Yes	0	6	6
468	B:B:F235	B:B:F278	7.5	Yes	No	0	6	7
469	B:B:F235	B:B:G282	6.02	Yes	No	15	6	9
470	B:B:F235	G:G:L37	13.4	Yes	No	0	6	7
471	B:B:F235	G:G:Y40	4.13	Yes	Yes	15	6	6
472	B:B:G282	B:B:P236	4.06	No	No	15	9	7
473	B:B:P236	G:G:Y40	4.17	No	Yes	15	7	6
474	B:B:N237	B:B:N239	12.26	No	No	0	5	2
475	B:B:N237	G:G:Y40	6.98	No	Yes	15	5	6
476	B:B:N239	B:B:R256	15.67	No	No	0	2	9
477	B:B:F241	B:B:F253	10.72	Yes	Yes	4	6	6
478	B:B:F241	B:B:L255	3.65	Yes	No	0	6	6
479	B:B:A242	B:B:L285	3.15	No	Yes	0	4	6
480	B:B:F253	B:B:T243	7.78	Yes	Yes	4	6	8
481	B:B:G244	B:B:I273	5.29	No	No	0	5	6
482	B:B:D247	B:B:T249	4.34	Yes	Yes	0	9	6
483	B:B:R251	B:B:T249	5.17	Yes	Yes	4	8	6
484	B:B:T249	B:B:T263	3.14	Yes	No	4	6	1
485	B:B:C250	B:B:Y264	5.38	No	Yes	0	8	5
486	B:B:C250	B:B:L285	3.17	No	Yes	0	8	6
487	B:B:F253	B:B:R251	4.28	Yes	Yes	4	6	8
488	B:B:E260	B:B:R251	19.77	No	Yes	4	6	8
489	B:B:R251	B:B:T263	7.76	Yes	No	4	8	1
490	B:B:L252	B:B:Y264	7.03	No	Yes	0	7	5
491	B:B:E260	B:B:F253	5.83	No	Yes	4	6	6
492	B:B:A257	B:B:D254	4.63	No	No	0	7	9
493	B:B:D254	B:B:L261	13.57	No	No	0	9	5
494	B:B:R256	G:G:I28	7.52	No	No	0	9	4
495	B:B:R256	G:G:D36	3.57	No	No	0	9	5
496	B:B:D258	G:G:R27	15.48	No	Yes	0	7	8
497	B:B:Q259	G:G:V30	5.73	Yes	No	0	6	8
498	B:B:M262	B:B:Y264	8.38	Yes	Yes	0	4	5
499	B:B:A302	B:B:M262	3.22	No	Yes	0	2	4
500	B:B:W297	B:B:Y264	5.79	Yes	Yes	0	8	5
501	B:B:H266	B:B:R304	7.9	No	Yes	0	4	5
502	B:B:I269	B:B:Y289	7.25	No	Yes	0	4	7
503	B:B:C271	B:B:D290	9.34	No	No	0	5	6
504	B:B:C271	B:B:D291	3.11	No	No	0	5	8
505	B:B:D290	B:B:G272	5.03	No	No	0	6	4
506	B:B:I273	B:B:Y289	8.46	No	Yes	0	6	7
507	B:B:S275	B:B:T274	3.2	No	No	0	8	8
508	B:B:L318	B:B:S275	3	Yes	No	0	6	8
509	B:B:L285	B:B:V276	4.47	Yes	No	0	6	6
510	B:B:L318	B:B:S277	6.01	Yes	No	0	6	5
511	B:B:G319	B:B:S277	3.71	No	No	0	5	5
512	B:B:S277	B:B:V320	3.23	No	No	0	5	7
513	B:B:F278	B:B:L285	9.74	No	Yes	0	7	6
514	B:B:S279	G:G:D48	4.42	No	Yes	17	9	9
515	B:B:S279	G:G:L50	6.01	No	No	17	9	9
516	B:B:G324	B:B:K280	3.49	No	No	0	9	1
517	B:B:S281	G:G:D48	4.42	No	Yes	17	9	9
518	B:B:S281	G:G:L51	3	No	Yes	17	9	6
519	B:B:D298	B:B:R283	11.91	No	Yes	0	9	9
520	B:B:R283	G:G:C41	5.57	Yes	No	0	9	7
521	B:B:R283	G:G:L51	7.29	Yes	Yes	0	9	6
522	B:B:L284	B:B:V296	4.47	No	No	0	5	5
523	B:B:L286	B:B:V296	5.96	No	No	0	7	5
524	B:B:L286	B:B:V327	5.96	No	No	0	7	6
525	B:B:A287	B:B:Y289	4	No	Yes	0	6	7
526	B:B:C294	B:B:G288	3.92	No	No	0	5	7
527	B:B:G288	B:B:V315	3.68	No	No	0	7	7
528	B:B:D291	B:B:Y289	4.6	No	Yes	0	8	7
529	B:B:N295	B:B:Y289	15.12	Yes	Yes	16	6	7
530	B:B:W297	B:B:Y289	8.68	Yes	Yes	16	8	7
531	B:B:D290	B:B:R314	17.87	No	No	0	6	8
532	B:B:D291	B:B:N293	5.39	No	No	0	8	5
533	B:B:A309	B:B:N293	3.13	No	No	0	3	5
534	B:B:C294	B:B:L308	4.76	No	No	0	5	7
535	B:B:C294	B:B:L318	4.76	No	Yes	0	5	6
536	B:B:N295	B:B:W297	4.52	Yes	Yes	16	6	8
537	B:B:N295	B:B:R304	12.05	Yes	Yes	16	6	5
538	B:B:N295	B:B:V307	5.91	Yes	No	16	6	3
539	B:B:R304	B:B:W297	13	Yes	Yes	16	5	8
540	B:B:D298	B:B:K301	4.15	No	No	0	9	5
541	B:B:L300	G:G:C41	6.35	No	No	0	6	7
542	B:B:D303	B:B:K301	4.15	No	No	0	2	5
543	B:B:R304	B:B:V307	3.92	Yes	No	16	5	3
544	B:B:L308	B:B:W339	21.64	No	Yes	0	7	9
545	B:B:H311	B:B:V315	4.15	Yes	No	0	9	7
546	B:B:H311	B:B:T329	6.85	Yes	No	14	9	8
547	B:B:H311	B:B:S331	15.34	Yes	No	0	9	9
548	B:B:H311	B:B:K337	9.17	Yes	Yes	14	9	6
549	B:B:H311	B:B:W339	3.17	Yes	Yes	14	9	9
550	B:B:D312	B:B:D333	6.65	No	No	0	5	9
551	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
552	B:B:R314	B:B:W332	22.99	No	Yes	0	8	9
553	B:B:S316	B:B:W332	6.18	No	Yes	0	9	9
554	B:B:L318	B:B:T329	2.95	Yes	No	0	6	8
555	B:B:V320	B:B:V327	6.41	No	No	0	7	6
556	B:B:D323	B:B:T321	8.67	No	No	10	7	7
557	B:B:D323	B:B:M325	6.93	No	No	0	7	5
558	B:B:M325	G:G:P49	6.71	No	No	0	5	7
559	B:B:M325	G:G:P60	10.06	No	Yes	0	5	9
560	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
561	B:B:V327	B:B:W339	3.68	No	Yes	0	6	9
562	B:B:A328	B:B:I338	4.87	No	No	0	5	5
563	B:B:T329	B:B:W339	9.7	No	Yes	14	8	9
564	B:B:D333	B:B:S331	5.89	No	No	0	9	9
565	B:B:D333	B:B:F335	8.36	No	No	0	9	4
566	B:B:K337	B:B:W339	6.96	Yes	Yes	14	6	9
567	B:B:N340	G:G:N59	9.54	No	Yes	9	9	9
568	B:B:N340	G:G:F61	4.83	No	Yes	9	9	8
569	G:G:E17	G:G:V16	4.28	No	No	0	6	7
570	G:G:E17	G:G:K20	9.45	No	No	0	6	6
571	G:G:E22	G:G:Q18	11.47	No	No	2	9	9
572	G:G:I25	G:G:R27	3.76	No	Yes	0	2	8
573	G:G:A33	G:G:I28	3.25	No	No	0	7	4
574	G:G:H44	G:G:Y40	18.51	No	Yes	0	6	6
575	G:G:A43	G:G:E42	4.53	No	No	0	4	1
576	G:G:E47	G:G:K46	5.4	No	No	0	3	1
577	G:G:D48	G:G:P49	8.05	Yes	No	0	9	7
578	G:G:D48	G:G:L50	9.5	Yes	No	17	9	9
579	G:G:D48	G:G:L51	9.5	Yes	Yes	17	9	6
580	G:G:E58	G:G:V54	7.13	No	No	0	5	6
581	G:G:N59	G:G:V54	4.43	Yes	No	0	9	6
582	G:G:E58	G:G:P55	12.58	No	No	0	5	5
583	G:G:E58	G:G:S57	8.62	No	No	0	5	6
584	G:G:N59	G:G:P60	8.15	Yes	Yes	9	9	9
585	G:G:F61	G:G:N59	3.62	Yes	Yes	9	8	9
586	G:G:F61	G:G:P60	5.78	Yes	Yes	9	8	9
587	G:G:E63	G:G:R62	8.14	No	No	0	6	7
588	L:L:A29	R:R:K108	3.21	No	Yes	0	0	5
589	L:L:K30	R:R:W104	3.48	No	Yes	0	0	6
590	L:L:K30	R:R:Y197	3.58	No	Yes	0	0	3
591	L:L:E31	R:R:D274	3.9	Yes	No	11	0	4
592	L:L:E31	R:R:R278	4.65	Yes	Yes	11	0	4
593	L:L:E31	R:R:R289	9.3	Yes	Yes	11	0	3
594	L:L:E31	R:R:L296	3.98	Yes	No	0	0	5
595	L:L:H60	L:L:L32	5.14	Yes	No	0	0	0
596	L:L:L32	R:R:Y197	16.41	No	Yes	0	0	3
597	L:L:R33	R:R:R289	19.19	No	Yes	0	0	3
598	L:L:C34	L:L:C61	7.28	No	Yes	0	0	0
599	L:L:Q35	R:R:P38	14.21	No	No	0	0	7
600	L:L:Q35	R:R:E40	3.82	No	No	0	0	4
601	L:L:C36	L:L:C77	7.28	No	No	0	0	0
602	L:L:I37	L:L:K38	8.72	No	No	0	0	0
603	L:L:K38	R:R:A36	3.21	No	No	0	0	5
604	L:L:D79	L:L:T39	4.34	No	No	0	0	0
605	L:L:K42	L:L:Y40	16.72	No	Yes	0	0	0
606	L:L:F44	L:L:Y40	4.13	No	Yes	0	0	0
607	L:L:L76	L:L:Y40	5.86	No	Yes	0	0	0
608	L:L:Y40	R:R:L34	12.89	Yes	No	0	0	2
609	L:L:K42	L:L:P43	3.35	No	No	0	0	0
610	L:L:P43	L:L:W84	12.16	No	Yes	0	0	0
611	L:L:F44	L:L:W84	12.03	No	Yes	0	0	0
612	L:L:H45	L:L:P46	4.58	No	No	0	0	0
613	L:L:H45	R:R:T28	6.85	No	No	0	0	7
614	L:L:P46	L:L:V88	8.84	No	No	0	0	0
615	L:L:K91	L:L:P46	8.36	No	No	0	0	0
616	L:L:K47	L:L:K91	5.75	No	No	0	0	0
617	L:L:F48	L:L:L70	4.87	No	No	0	0	0
618	L:L:F48	R:R:F32	8.57	No	No	0	0	3
619	L:L:I49	L:L:V68	3.07	No	No	0	0	0
620	L:L:F92	L:L:I49	6.28	No	No	0	0	0
621	L:L:E51	L:L:R53	4.65	No	No	0	0	0
622	L:L:E51	L:L:K69	5.4	No	No	0	0	0
623	L:L:F92	L:L:L52	7.31	No	No	0	0	0
624	L:L:I67	L:L:R53	5.01	No	No	0	0	0
625	L:L:E65	L:L:I55	12.3	No	No	0	0	0
626	L:L:S57	R:R:N202	5.96	No	No	0	0	2
627	L:L:G58	L:L:P59	4.06	No	No	0	0	0
628	L:L:H60	L:L:P59	3.05	Yes	No	0	0	0
629	L:L:P59	R:R:V187	5.3	No	No	0	0	3
630	L:L:C61	L:L:H60	7.37	Yes	Yes	26	0	0
631	L:L:E65	L:L:H60	3.69	No	Yes	26	0	0
632	L:L:C61	L:L:E65	9.12	Yes	No	26	0	0
633	L:L:N63	L:L:T64	5.85	No	No	28	0	0
634	L:L:N63	L:L:P80	3.26	No	Yes	28	0	0
635	L:L:P80	L:L:T64	5.25	Yes	No	28	0	0
636	L:L:I66	L:L:V68	3.07	No	No	0	0	0
637	L:L:L78	L:L:V68	2.98	No	No	0	0	0
638	L:L:D72	L:L:L70	14.93	Yes	No	0	0	0
639	L:L:D72	L:L:G73	3.35	Yes	No	0	0	0
640	L:L:D72	L:L:R74	9.53	Yes	Yes	27	0	0
641	L:L:D72	R:R:F32	4.78	Yes	No	27	0	3
642	L:L:R74	R:R:F32	6.41	Yes	No	27	0	3
643	L:L:R74	R:R:L33	4.86	Yes	No	0	0	3
644	L:L:R74	R:R:D35	10.72	Yes	No	0	0	6
645	L:L:E75	R:R:A37	6.03	No	No	0	0	7
646	L:L:D79	L:L:P80	6.44	No	Yes	0	0	0
647	L:L:D79	L:L:K81	6.91	No	No	0	0	0
648	L:L:P80	L:L:Q86	3.16	Yes	No	0	0	0
649	L:L:E82	L:L:N83	6.57	No	No	0	0	0
650	L:L:V85	L:L:W84	8.58	No	Yes	0	0	0
651	L:L:V88	L:L:W84	8.58	No	Yes	0	0	0
652	L:L:E90	L:L:Q86	3.82	No	No	0	0	0
653	L:L:E90	L:L:V89	8.56	No	No	0	0	0
654	R:R:L29	R:R:P31	9.85	No	No	0	3	5
655	R:R:P30	R:R:P31	5.84	No	No	0	3	5
656	R:R:A36	R:R:L34	4.73	No	No	0	5	2
657	R:R:C286	R:R:C39	7.28	No	No	0	6	8
658	R:R:E40	R:R:N191	7.89	No	No	0	4	2
659	R:R:N290	R:R:P41	9.77	No	No	0	3	4
660	R:R:I46	R:R:L44	5.71	No	No	0	5	2
661	R:R:E45	R:R:K48	4.05	No	No	0	4	4
662	R:R:E45	R:R:Y49	5.61	No	No	0	4	2
663	R:R:N47	R:R:V51	2.96	No	No	0	4	5
664	R:R:D297	R:R:N47	10.77	No	No	0	4	4
665	R:R:K108	R:R:K48	4.31	Yes	No	0	5	4
666	R:R:K108	R:R:V51	3.04	Yes	No	0	5	5
667	R:R:I301	R:R:V51	3.07	No	No	0	5	5
668	R:R:V109	R:R:V52	3.21	No	No	0	4	5
669	R:R:I301	R:R:I54	4.42	No	No	0	5	5
670	R:R:L101	R:R:Y55	3.52	Yes	No	20	8	7
671	R:R:A105	R:R:Y55	4	No	No	0	7	7
672	R:R:I304	R:R:Y55	4.84	No	No	20	7	7
673	R:R:L101	R:R:V58	2.98	Yes	No	20	8	7
674	R:R:I304	R:R:V58	3.07	No	No	20	7	7
675	R:R:F59	R:R:L63	6.09	No	No	0	7	5
676	R:R:F59	R:R:L101	7.31	No	Yes	0	7	8
677	R:R:F59	R:R:P102	10.11	No	No	0	7	9
678	R:R:L61	R:R:S62	3	No	No	0	5	8
679	R:R:C308	R:R:L61	4.76	No	No	0	7	5
680	R:R:S307	R:R:S62	3.26	No	No	0	8	8
681	R:R:L63	R:R:L95	4.15	No	No	0	5	7
682	R:R:D94	R:R:N66	8.08	No	No	0	9	9
683	R:R:L95	R:R:N66	4.12	No	No	0	7	9
684	R:R:N66	R:R:P311	9.77	No	No	0	9	9
685	R:R:L95	R:R:S67	6.01	No	No	0	7	3
686	R:R:F316	R:R:L68	4.87	No	No	0	6	6
687	R:R:A91	R:R:V69	3.39	No	No	0	8	8
688	R:R:A315	R:R:V69	3.39	No	No	0	7	8
689	R:R:F316	R:R:V69	3.93	No	No	0	6	8
690	R:R:F321	R:R:V72	5.24	Yes	No	0	8	7
691	R:R:L325	R:R:V72	2.98	No	No	0	6	7
692	R:R:I73	R:R:L74	4.28	No	No	0	6	2
693	R:R:I73	R:R:L88	4.28	No	No	0	6	5
694	R:R:F321	R:R:I73	3.77	Yes	No	0	8	6
695	R:R:I328	R:R:Y75	13.3	No	No	0	5	4
696	R:R:I331	R:R:Y75	3.63	No	No	29	2	4
697	R:R:H332	R:R:Y75	5.44	No	No	29	3	4
698	R:R:S76	R:R:V78	3.23	No	No	0	4	5
699	R:R:D84	R:R:G79	5.03	No	No	0	8	6
700	R:R:S81	R:R:T83	3.2	No	No	0	7	7
701	R:R:D84	R:R:S81	10.31	No	No	0	8	7
702	R:R:D143	R:R:V82	10.22	No	No	30	8	7
703	R:R:K158	R:R:V82	9.11	Yes	No	30	6	7
704	R:R:V162	R:R:V82	6.41	Yes	No	0	7	7
705	R:R:C139	R:R:Y86	9.41	No	Yes	0	5	7
706	R:R:I140	R:R:Y86	4.84	No	Yes	0	9	7
707	R:R:D143	R:R:Y86	8.05	No	Yes	0	8	7
708	R:R:V162	R:R:Y86	5.05	Yes	Yes	0	7	7
709	R:R:A315	R:R:L87	3.15	No	No	0	7	7
710	R:R:L88	R:R:N89	4.12	No	No	0	5	9
711	R:R:C166	R:R:N89	7.87	No	No	0	7	9
712	R:R:N89	R:R:W170	5.65	No	Yes	0	9	9
713	R:R:L136	R:R:L90	4.15	No	No	0	8	9
714	R:R:L137	R:R:L90	4.15	Yes	No	0	8	9
715	R:R:L90	R:R:N310	9.61	No	Yes	0	9	9
716	R:R:A93	R:R:N129	3.13	No	Yes	0	8	8
717	R:R:D94	R:R:S307	10.31	No	No	0	9	8
718	R:R:D94	R:R:N310	8.08	No	Yes	0	9	9
719	R:R:L125	R:R:L96	4.15	No	No	0	4	7
720	R:R:L96	R:R:N129	9.61	No	Yes	0	7	8
721	R:R:F97	R:R:K126	8.69	No	No	0	6	6
722	R:R:F97	R:R:N129	6.04	No	Yes	0	6	8
723	R:R:A98	R:R:L101	3.15	No	Yes	0	5	8
724	R:R:T100	R:R:V122	3.17	No	No	0	7	5
725	R:R:L125	R:R:T100	4.42	No	No	0	4	7
726	R:R:K126	R:R:T100	7.51	No	No	0	6	7
727	R:R:I304	R:R:L101	4.28	No	Yes	20	7	8
728	R:R:I103	R:R:P102	3.39	No	No	0	6	9
729	R:R:K108	R:R:W104	4.64	Yes	Yes	0	5	6
730	R:R:S123	R:R:W104	4.94	No	Yes	0	5	6
731	R:R:K126	R:R:W104	9.28	No	Yes	0	6	6
732	R:R:S107	R:R:W112	8.65	No	Yes	0	5	9
733	R:R:N110	R:R:V109	4.43	No	No	0	4	4
734	R:R:L118	R:R:W112	9.11	No	Yes	0	6	9
735	R:R:C119	R:R:W112	7.84	No	Yes	0	9	9
736	R:R:T186	R:R:W112	3.64	No	Yes	0	4	9
737	R:R:F114	R:R:G115	4.52	No	No	0	6	8
738	R:R:F114	R:R:L118	7.31	No	No	0	6	6
739	R:R:K120	R:R:T116	3	No	No	0	7	3
740	R:R:C119	R:R:C196	7.28	No	No	0	9	9
741	R:R:K120	R:R:L181	7.05	No	No	0	7	5
742	R:R:K120	R:R:R184	4.95	No	Yes	0	7	5
743	R:R:R184	R:R:S123	13.18	Yes	No	0	5	5
744	R:R:L124	R:R:L181	5.54	No	No	0	6	5
745	R:R:E127	R:R:F130	10.49	No	Yes	5	4	7
746	R:R:E127	R:R:Y131	13.47	No	Yes	5	4	7
747	R:R:N129	R:R:V128	4.43	Yes	Yes	0	8	5
748	R:R:S173	R:R:V128	4.85	No	Yes	0	7	5
749	R:R:L174	R:R:V128	4.47	No	Yes	0	5	5
750	R:R:F130	R:R:Y131	9.28	Yes	Yes	5	7	7
751	R:R:F130	R:R:Q216	11.71	Yes	Yes	5	7	5
752	R:R:F130	R:R:W264	11.02	Yes	Yes	5	7	8
753	R:R:S173	R:R:Y131	3.82	No	Yes	0	7	7
754	R:R:L176	R:R:Y131	12.89	No	Yes	5	4	7
755	R:R:P215	R:R:Y131	5.56	No	Yes	0	5	7
756	R:R:Q216	R:R:Y131	5.64	Yes	Yes	5	5	7
757	R:R:S132	R:R:W170	13.59	No	Yes	0	6	9
758	R:R:S132	R:R:S173	3.26	No	No	0	6	7
759	R:R:I134	R:R:P223	3.39	Yes	No	0	8	9
760	R:R:F260	R:R:I134	7.54	Yes	Yes	5	9	8
761	R:R:I134	R:R:W264	4.7	Yes	Yes	5	8	8
762	R:R:H306	R:R:I134	3.98	Yes	Yes	5	9	8
763	R:R:L135	R:R:L172	4.15	No	No	0	6	4
764	R:R:C139	R:R:L136	3.17	No	No	0	5	8
765	R:R:F260	R:R:L137	3.65	Yes	Yes	0	9	8
766	R:R:H306	R:R:L137	3.86	Yes	Yes	0	9	8
767	R:R:L137	R:R:Y314	11.72	Yes	Yes	0	8	9
768	R:R:A138	R:R:P223	3.74	No	No	0	7	9
769	R:R:I140	R:R:R144	5.01	No	Yes	0	9	9
770	R:R:M227	R:R:S141	6.13	No	No	0	8	9
771	R:R:C230	R:R:S141	3.44	No	No	6	7	9
772	R:R:S141	R:R:Y231	6.36	No	Yes	6	9	9
773	R:R:D143	R:R:K158	6.91	No	Yes	30	8	6
774	R:R:R144	R:R:Y231	10.29	Yes	Yes	0	9	9
775	R:R:L146	R:R:Y145	3.52	No	Yes	0	5	8
776	R:R:V149	R:R:Y145	11.36	No	Yes	6	7	8
777	R:R:H150	R:R:Y145	6.53	No	Yes	6	6	8
778	R:R:C230	R:R:Y145	4.03	No	Yes	6	7	8
779	R:R:F233	R:R:Y145	6.19	No	Yes	0	4	8
780	R:R:L146	R:R:T154	2.95	No	No	0	5	5
781	R:R:A147	R:R:K158	4.82	No	Yes	0	8	6
782	R:R:I148	R:R:T234	3.04	Yes	No	0	8	8
783	R:R:H150	R:R:V149	4.15	No	No	6	6	7
784	R:R:T237	R:R:V149	7.93	No	No	0	5	7
785	R:R:H150	R:R:T154	9.58	No	No	0	6	5
786	R:R:R153	R:R:T152	11.64	No	No	0	5	5
787	R:R:I165	R:R:L161	4.28	No	No	0	5	4
788	R:R:K163	R:R:V162	4.55	No	Yes	0	4	7
789	R:R:I165	R:R:S168	3.1	No	No	0	5	2
790	R:R:L172	R:R:L176	4.15	No	No	5	4	4
791	R:R:F218	R:R:L172	3.65	Yes	No	5	4	4
792	R:R:F218	R:R:L176	4.87	Yes	No	5	4	4
793	R:R:L211	R:R:P179	6.57	No	No	0	4	8
794	R:R:R184	R:R:V180	3.92	Yes	No	0	5	4
795	R:R:F183	R:R:L182	8.53	No	No	0	5	4
796	R:R:D199	R:R:F183	10.75	Yes	No	0	4	5
797	R:R:C196	R:R:R184	5.57	No	Yes	31	9	5
798	R:R:E198	R:R:R184	27.91	No	Yes	31	5	5
799	R:R:M200	R:R:R185	6.2	No	No	0	5	4
800	R:R:T186	R:R:Y188	6.24	No	No	0	4	1
801	R:R:V187	R:R:Y197	5.05	No	Yes	0	3	3
802	R:R:P194	R:R:Y188	8.34	No	No	0	5	1
803	R:R:S189	R:R:V192	3.23	No	No	0	1	5
804	R:R:C196	R:R:E198	3.04	No	No	31	9	5
805	R:R:R208	R:R:Y197	4.12	No	Yes	0	4	3
806	R:R:D199	R:R:W207	3.35	Yes	No	0	4	3
807	R:R:N203	R:R:N206	5.45	No	No	0	4	1
808	R:R:N203	R:R:W207	6.78	No	No	0	4	3
809	R:R:R208	R:R:R278	4.26	No	Yes	0	4	4
810	R:R:M209	R:R:T275	7.53	No	No	0	3	4
811	R:R:M209	R:R:R278	7.44	No	Yes	0	3	4
812	R:R:L271	R:R:R212	10.93	No	No	0	6	5
813	R:R:D274	R:R:R212	13.1	No	No	11	4	5
814	R:R:R212	R:R:T275	6.47	No	No	11	5	4
815	R:R:L214	R:R:P215	4.93	No	No	0	3	5
816	R:R:N268	R:R:Q216	6.6	No	Yes	0	8	5
817	R:R:L271	R:R:Q216	5.32	No	Yes	0	6	5
818	R:R:I221	R:R:S217	3.1	No	No	0	4	4
819	R:R:F218	R:R:V222	5.24	Yes	No	0	4	5
820	R:R:F220	R:R:N268	16.92	No	No	0	8	8
821	R:R:P223	R:R:V222	3.53	No	No	0	9	5
822	R:R:L224	R:R:L261	5.54	No	No	0	7	6
823	R:R:F229	R:R:L225	7.31	No	No	0	4	3
824	R:R:F260	R:R:M227	6.22	Yes	No	0	9	8
825	R:R:L228	R:R:V257	2.98	No	No	0	4	7
826	R:R:C230	R:R:Y231	5.38	No	Yes	6	7	9
827	R:R:I253	R:R:Y231	6.04	No	Yes	0	7	9
828	R:R:V256	R:R:Y231	5.05	No	Yes	6	8	9
829	R:R:I253	R:R:L235	12.85	No	No	0	7	4
830	R:R:F254	R:R:L235	7.31	No	No	0	4	4
831	R:R:F239	R:R:M250	3.73	No	No	0	5	5
832	R:R:A241	R:R:M243	3.22	No	Yes	0	3	4
833	R:R:K246	R:R:M243	5.76	No	Yes	0	7	4
834	R:R:H247	R:R:R251	4.51	No	No	0	5	5
835	R:R:I317	R:R:R248	3.76	No	No	0	6	7
836	R:R:F254	R:R:M250	3.73	No	No	0	4	5
837	R:R:I317	R:R:V252	3.07	No	No	0	6	7
838	R:R:I313	R:R:V256	3.07	No	No	6	7	8
839	R:R:V256	R:R:Y314	7.57	No	Yes	6	8	9
840	R:R:L261	R:R:V257	2.98	No	No	0	6	7
841	R:R:I259	R:R:L309	4.28	No	No	0	6	6
842	R:R:F260	R:R:W264	7.02	Yes	Yes	5	9	8
843	R:R:L261	R:R:L265	4.15	No	No	0	6	6
844	R:R:C263	R:R:W264	3.92	No	Yes	5	7	8
845	R:R:C263	R:R:H306	7.37	No	Yes	5	7	9
846	R:R:W264	R:R:Y267	6.75	Yes	Yes	0	8	7
847	R:R:G303	R:R:W264	5.63	No	Yes	0	7	8
848	R:R:H306	R:R:W264	16.93	Yes	Yes	5	9	8
849	R:R:L265	R:R:P266	3.28	No	No	0	6	9
850	R:R:P266	R:R:T299	3.5	No	No	0	9	6
851	R:R:L302	R:R:P266	3.28	No	No	0	7	9
852	R:R:N268	R:R:Y267	5.81	No	Yes	0	8	7
853	R:R:L271	R:R:Y267	3.52	No	Yes	0	6	7
854	R:R:T299	R:R:Y267	7.49	No	Yes	0	6	7
855	R:R:E300	R:R:Y267	17.96	No	Yes	0	5	7
856	R:R:L296	R:R:V270	2.98	No	No	0	5	4
857	R:R:T299	R:R:V270	3.17	No	No	0	6	4
858	R:R:D274	R:R:T275	4.34	No	No	11	4	4
859	R:R:L276	R:R:V281	5.96	No	No	0	4	4
860	R:R:I282	R:R:M277	4.37	No	Yes	0	5	4
861	R:R:M277	R:R:R289	3.72	Yes	Yes	0	4	3
862	R:R:R278	R:R:R289	8.53	Yes	Yes	11	4	3
863	R:R:L302	R:R:L305	4.15	No	No	0	7	5
864	R:R:C308	R:R:L309	4.76	No	No	0	7	6
865	R:R:L309	R:R:L312	5.54	No	No	0	6	6
866	R:R:N310	R:R:P311	4.89	Yes	No	0	9	9
867	R:R:N310	R:R:Y314	6.98	Yes	Yes	0	9	9
868	R:R:I313	R:R:Y314	6.04	No	Yes	6	7	9
869	R:R:A315	R:R:F321	4.16	No	Yes	0	7	8
870	R:R:H323	R:R:Q319	11.13	No	No	0	4	5
871	R:R:F321	R:R:K320	3.72	Yes	No	0	8	6
872	R:R:I328	R:R:K327	5.82	No	No	0	5	4
873	R:R:H332	R:R:I331	6.63	No	No	29	3	2
874	A:A:D9	A:A:S6	2.94	Yes	No	0	4	7
875	A:A:D350	R:R:S81	2.94	No	No	0	4	7
876	A:A:D200	A:A:V185	2.92	No	No	0	9	5
877	A:A:I344	R:R:M243	2.92	No	Yes	0	6	4
878	B:B:I43	B:B:M45	2.92	No	No	0	3	4
879	B:B:N125	B:B:T128	2.92	No	No	0	4	3
880	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
881	R:R:G219	R:R:Y131	2.9	No	Yes	0	5	7
882	A:A:D261	A:A:T260	2.89	No	No	0	4	3
883	B:B:D322	B:B:T65	2.89	No	No	0	1	1
884	R:R:D199	R:R:T204	2.89	Yes	No	0	4	3
885	A:A:I303	A:A:L227	2.85	No	No	0	7	7
886	A:A:I319	A:A:L266	2.85	No	No	0	5	9
887	A:A:I303	A:A:L283	2.85	No	No	0	7	7
888	A:A:L348	R:R:I148	2.85	Yes	Yes	0	9	8
889	B:B:E10	G:G:V16	2.85	No	No	0	8	7
890	L:L:E82	L:L:V85	2.85	No	No	0	0	0
891	R:R:I113	R:R:L118	2.85	No	No	0	3	6
892	R:R:I169	R:R:L135	2.85	No	No	0	6	6
893	R:R:I169	R:R:L136	2.85	No	No	0	6	8
894	R:R:I148	R:R:L238	2.85	Yes	No	0	8	8
895	R:R:I282	R:R:L276	2.85	No	No	0	5	4
896	A:A:L234	A:A:M240	2.83	No	No	0	8	6
897	A:A:I319	A:A:N311	2.83	No	No	0	5	8
898	B:B:I171	B:B:N155	2.83	No	No	0	6	3
899	B:B:Q175	B:B:T173	2.83	No	No	0	4	5
900	R:R:L71	R:R:M70	2.83	No	No	0	3	6
901	R:R:Q157	R:R:T154	2.83	No	No	0	7	5
902	A:A:K46	A:A:L38	2.82	No	No	0	9	8
903	A:A:K270	A:A:L273	2.82	No	No	0	9	6
904	B:B:L14	G:G:K20	2.82	Yes	No	0	8	6
905	L:L:K42	R:R:L29	2.82	No	No	0	0	3
906	L:L:K50	L:L:L70	2.82	No	No	0	0	0
907	B:B:G53	B:B:W82	2.81	No	Yes	0	9	9
908	B:B:G141	B:B:W169	2.81	No	Yes	0	5	8
909	B:B:D38	B:B:I37	2.8	No	Yes	0	1	2
910	B:B:D118	B:B:I120	2.8	No	No	0	9	6
911	B:B:H54	B:B:S334	2.79	Yes	No	0	9	4
912	L:L:H60	R:R:S189	2.79	Yes	No	0	0	1
913	B:B:D27	G:G:K29	2.77	No	No	0	8	4
914	B:B:L261	B:B:L30	2.77	No	Yes	0	5	5
915	B:B:A106	B:B:F151	2.77	No	No	0	6	9
916	B:B:A113	B:B:F151	2.77	No	No	0	9	9
917	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
918	G:G:L15	G:G:L19	2.77	No	Yes	0	2	9
919	L:L:L76	L:L:L78	2.77	No	No	0	0	0
920	R:R:L57	R:R:L61	2.77	No	No	0	5	5
921	R:R:L265	R:R:L269	2.77	No	No	0	6	6
922	B:B:H183	B:B:T164	2.74	Yes	No	0	9	6
923	A:A:E308	A:A:I319	2.73	No	No	0	3	5
924	L:L:E56	L:L:I55	2.73	No	No	0	0	0
925	L:L:E75	L:L:I67	2.73	No	No	0	0	0
926	A:A:K192	A:A:Q333	2.71	No	No	0	4	5
927	A:A:E245	A:A:M240	2.71	No	No	0	9	6
928	B:B:D66	B:B:L69	2.71	No	No	0	8	5
929	B:B:E215	B:B:M217	2.71	No	No	0	3	3
930	R:R:E284	R:R:M277	2.71	No	Yes	0	3	4
931	R:R:D293	R:R:N290	2.69	No	No	0	4	3
932	A:A:A299	A:A:Y290	2.67	No	Yes	0	7	7
933	B:B:L7	B:B:Q6	2.66	No	No	0	8	1
934	B:B:L14	B:B:Q13	2.66	Yes	No	0	8	1
935	A:A:F191	A:A:V332	2.62	No	No	0	5	7
936	B:B:F335	R:R:V78	2.62	No	No	0	4	5
937	R:R:R80	R:R:V85	2.62	No	No	0	7	6
938	A:A:D315	R:R:Q245	2.61	No	No	0	3	4
939	A:A:R313	A:A:T316	2.59	No	No	0	4	3
940	A:A:F336	R:R:T152	2.59	No	No	0	8	5
941	R:R:R185	R:R:T116	2.59	No	No	0	4	3
942	R:R:R236	R:R:T237	2.59	No	No	0	4	5
943	R:R:R288	R:R:T285	2.59	No	No	0	1	5
944	A:A:H244	A:A:N241	2.55	No	No	0	4	9
945	B:B:H266	B:B:N268	2.55	No	No	0	4	4
946	B:B:I18	G:G:R27	2.51	No	Yes	0	7	8
947	L:L:F48	L:L:I49	2.51	No	No	0	0	0
948	L:L:I55	L:L:R53	2.51	No	No	0	0	0
949	R:R:F50	R:R:I53	2.51	No	No	0	5	5
950	A:A:K17	A:A:R21	2.48	No	No	0	4	4
951	R:R:K158	R:R:R159	2.48	Yes	No	0	6	3
952	R:R:F183	R:R:L211	2.44	No	No	0	5	4
953	B:B:L190	B:B:R150	2.43	Yes	Yes	0	5	6
954	B:B:L192	B:B:R150	2.43	No	Yes	0	5	6
955	B:B:F292	B:B:N313	2.42	No	No	0	4	7
956	R:R:I165	R:R:Y86	2.42	No	Yes	0	5	7
957	R:R:D199	R:R:R208	2.38	Yes	No	0	4	4
958	B:B:Q156	B:B:R214	2.34	Yes	No	0	5	9
959	R:R:Q319	R:R:R322	2.34	No	No	0	5	8
960	B:B:E130	B:B:R129	2.33	No	No	0	3	3
961	R:R:L92	R:R:W170	2.28	No	Yes	0	6	9
962	A:A:R15	B:B:H91	2.26	No	Yes	0	5	5
963	A:A:G183	A:A:G203	2.11	No	No	0	9	9
964	A:A:G202	A:A:G203	2.11	No	No	0	9	9
965	A:A:G352	R:R:G318	2.11	No	No	0	8	7
966	B:B:G115	B:B:G116	2.11	No	No	0	9	9
967	B:B:G238	B:B:P194	2.03	No	No	0	7	4
968	B:B:G324	G:G:P49	2.03	No	No	0	9	7
969	A:A:A41	A:A:G42	1.95	No	No	0	7	8
970	B:B:A305	B:B:G306	1.95	No	No	0	4	4
971	B:B:A309	B:B:G310	1.95	No	No	0	3	5
972	R:R:C39	R:R:P41	1.88	No	No	0	8	4
973	R:R:A37	R:R:P38	1.87	No	No	0	7	7
974	R:R:G111	R:R:S107	1.86	No	No	0	4	5
975	R:R:G111	R:R:S193	1.86	No	No	0	4	3
976	R:R:G133	R:R:S132	1.86	No	No	0	9	6
977	B:B:G41	B:B:V40	1.84	No	No	0	1	3
978	B:B:G115	B:B:T102	1.82	No	No	0	9	8
979	B:B:G174	B:B:T173	1.82	No	No	0	4	5
980	B:B:G224	B:B:T223	1.82	No	No	0	6	2
981	R:R:G201	R:R:T204	1.82	No	No	0	4	3
982	R:R:G318	R:R:I317	1.76	No	No	0	7	6
983	A:A:P282	A:A:T284	1.75	No	No	0	5	4
984	B:B:P107	B:B:T65	1.75	No	No	0	6	1
985	G:G:P53	G:G:T52	1.75	No	No	0	8	4
986	R:R:G244	R:R:M243	1.75	No	Yes	0	4	4
987	A:A:G45	A:A:K270	1.74	No	No	0	9	9
988	R:R:G324	R:R:K320	1.74	No	No	0	5	6
989	R:R:G324	R:R:K327	1.74	No	No	0	5	4
990	L:L:C61	L:L:S57	1.72	Yes	No	0	0	0
991	A:A:G27	B:B:L55	1.71	No	No	0	5	6
992	B:B:C233	B:B:V276	1.71	No	No	0	3	6
993	R:R:G65	R:R:L64	1.71	No	No	0	7	4
994	R:R:G65	R:R:L68	1.71	No	No	0	7	6
995	B:B:A11	G:G:V16	1.7	No	No	0	5	7
996	R:R:A177	R:R:V128	1.7	No	Yes	0	7	5
997	R:R:A295	R:R:V270	1.7	No	No	0	5	4
998	A:A:C325	A:A:T327	1.69	No	No	0	7	8
999	L:L:C36	L:L:T39	1.69	No	No	0	0	0
1000	A:A:A326	A:A:T327	1.68	No	No	0	9	8
1001	A:A:E216	A:A:G217	1.64	No	No	0	7	5
1002	B:B:E260	B:B:G224	1.64	No	No	0	6	6
1003	L:L:C77	L:L:I67	1.64	No	No	0	0	0
1004	R:R:L178	R:R:P179	1.64	No	No	0	3	8
1005	R:R:S26	R:R:S27	1.63	No	No	0	6	7
1006	R:R:S189	R:R:S190	1.63	No	No	0	1	2
1007	A:A:I343	R:R:A151	1.62	No	No	0	7	8
1008	A:A:I344	R:R:A151	1.62	No	No	0	6	8
1009	B:B:I18	G:G:A23	1.62	No	No	0	7	8
1010	B:B:I33	G:G:A34	1.62	No	No	0	3	6
1011	R:R:A138	R:R:I226	1.62	No	No	0	7	6
1012	R:R:A255	R:R:I313	1.62	No	No	0	5	7
1013	R:R:A273	R:R:I292	1.62	No	No	0	5	5
1014	A:A:K180	B:B:A140	1.61	No	No	0	7	5
1015	B:B:D38	B:B:P39	1.61	No	No	0	1	1
1016	B:B:S31	B:B:T29	1.6	No	No	0	1	3
1017	B:B:S265	B:B:T249	1.6	No	Yes	4	2	6
1018	B:B:S265	B:B:T263	1.6	No	No	4	2	1
1019	R:R:V162	R:R:V85	1.6	Yes	No	0	7	6
1020	R:R:V121	R:R:V122	1.6	No	No	0	5	5
1021	A:A:T187	A:A:V50	1.59	No	No	0	6	6
1022	R:R:C263	R:R:L262	1.59	No	No	0	7	5
1023	R:R:T279	R:R:V281	1.59	No	No	0	1	4
1024	A:A:L348	R:R:A249	1.58	Yes	No	25	9	7
1025	A:A:L353	R:R:A249	1.58	Yes	No	25	7	7
1026	B:B:L4	G:G:A12	1.58	No	No	0	4	5
1027	B:B:L30	G:G:A34	1.58	Yes	No	0	5	6
1028	B:B:A299	B:B:L285	1.58	No	Yes	0	5	6
1029	G:G:A45	G:G:L51	1.58	No	Yes	0	4	6
1030	B:B:T165	B:B:T181	1.57	Yes	No	0	7	2
1031	R:R:E40	R:R:P41	1.57	No	No	0	4	4
1032	G:G:A23	G:G:N24	1.56	No	No	0	8	1
1033	B:B:I33	G:G:S31	1.55	No	No	0	3	9
1034	A:A:A12	A:A:D9	1.54	No	Yes	0	4	4
1035	A:A:I221	A:A:V218	1.54	No	No	0	8	9
1036	G:G:A35	G:G:D36	1.54	No	No	0	2	5
1037	L:L:I66	L:L:V54	1.54	No	No	0	0	0
1038	L:L:I66	L:L:V89	1.54	No	No	0	0	0
1039	R:R:I53	R:R:V52	1.54	No	No	0	5	5
1040	R:R:A298	R:R:D297	1.54	No	No	0	5	4
1041	B:B:C25	B:B:Q259	1.53	No	Yes	0	3	6
1042	R:R:M70	R:R:S67	1.53	No	No	0	6	3
1043	A:A:A301	A:A:Q304	1.52	No	No	0	3	5
1044	B:B:A21	B:B:Q17	1.52	No	No	0	4	4
1045	G:G:A12	G:G:Q11	1.52	No	No	0	5	3
1046	R:R:C286	R:R:E287	1.52	No	No	0	6	4
1047	A:A:A235	A:A:E236	1.51	No	No	0	4	9
1048	A:A:A291	A:A:E289	1.51	No	No	0	3	6
1049	A:A:K54	A:A:T187	1.5	No	No	0	7	6
1050	A:A:K330	A:A:T329	1.5	No	No	0	4	9
1051	R:R:L258	R:R:V257	1.49	No	No	0	5	7
1052	A:A:N346	A:A:V342	1.48	No	No	0	4	7
1053	G:G:L51	G:G:T52	1.47	Yes	No	0	6	4
1054	R:R:I53	R:R:I54	1.47	No	No	0	5	5
1055	R:R:L155	R:R:T156	1.47	No	No	0	4	2
1056	B:B:A104	B:B:H62	1.46	No	No	0	7	6
1057	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
1058	G:G:A43	G:G:H44	1.46	No	No	0	4	6
1059	R:R:I292	R:R:M277	1.46	No	Yes	0	5	4
1060	A:A:E8	A:A:S6	1.44	No	No	0	5	7
1061	A:A:K248	A:A:M240	1.44	No	No	0	5	6
1062	L:L:E82	L:L:S41	1.44	No	No	0	0	0
1063	B:B:L7	G:G:I9	1.43	No	No	0	8	2
1064	B:B:Q32	B:B:T29	1.42	No	No	0	1	3
1065	R:R:Q280	R:R:T279	1.42	No	No	0	2	1
1066	A:A:K10	A:A:L5	1.41	No	No	0	3	2
1067	R:R:G171	R:R:W170	1.41	No	Yes	0	4	9
1068	R:R:E287	R:R:T285	1.41	No	No	0	4	5
1069	A:A:D231	A:A:I285	1.4	No	No	0	9	3
1070	A:A:P288	A:A:Y287	1.39	No	Yes	0	5	7
1071	A:A:L23	B:B:L55	1.38	No	No	0	6	6
1072	A:A:D26	B:B:K78	1.38	No	Yes	0	5	8
1073	R:R:A205	R:R:R278	1.38	No	Yes	0	1	4
1074	A:A:H195	A:A:T190	1.37	No	No	0	4	3
1075	A:A:D9	B:B:N88	1.35	Yes	Yes	0	4	7
1076	R:R:E42	R:R:K48	1.35	No	No	0	4	4
1077	A:A:C305	A:A:Y302	1.34	No	Yes	0	3	6
1078	B:B:L14	B:B:Q17	1.33	Yes	No	0	8	4
1079	G:G:L19	G:G:Q18	1.33	Yes	No	2	9	9
1080	G:G:E22	G:G:L19	1.33	No	Yes	2	9	9
1081	L:L:R87	R:R:S26	1.32	No	No	0	0	6
1082	R:R:F218	R:R:S217	1.32	Yes	No	0	4	4
1083	B:B:D20	B:B:Q17	1.31	No	No	0	2	4
1084	B:B:E130	B:B:N132	1.31	No	No	0	3	3
1085	L:L:R87	L:L:V88	1.31	No	No	0	0	0
1086	R:R:F117	R:R:V121	1.31	No	No	0	1	5
1087	A:A:D237	A:A:E236	1.3	No	No	0	8	9
1088	A:A:D309	A:A:E308	1.3	No	No	0	4	3
1089	B:B:R129	B:B:T128	1.29	No	No	0	3	3
1090	A:A:S281	A:A:Y230	1.27	No	Yes	0	7	8
1091	B:B:E3	B:B:Q6	1.27	No	No	0	5	1
1092	R:R:E284	R:R:Q283	1.27	No	No	0	3	2
1093	A:A:F189	A:A:M53	1.24	No	No	0	9	8
1094	R:R:F164	R:R:L161	1.22	No	No	0	3	4
1095	A:A:N22	A:A:R21	1.21	No	No	0	4	4
1096	B:B:L7	G:G:R13	1.21	No	No	0	8	6
1097	R:R:N47	R:R:R294	1.21	No	No	0	4	2
1098	B:B:Q44	B:B:R46	1.17	No	No	0	4	5
1099	A:A:E28	A:A:R24	1.16	No	No	0	4	3
1100	A:A:N294	A:A:Y290	1.16	No	Yes	0	3	7
1101	G:G:E17	G:G:R13	1.16	No	No	0	6	6
1102	B:B:R49	G:G:R62	1.07	No	No	0	7	7
1103	R:R:R248	R:R:R322	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:D9	2.815	4	0	4
2	A:A:V34	5.634	5	8	5
3	A:A:F196	7.094	5	8	7
4	A:A:F199	9.824	5	1	5
5	A:A:K210	7.26	4	1	9
6	A:A:W211	5.755	6	0	9
7	A:A:C214	5.2375	4	1	7
8	A:A:F215	7.0875	4	1	9
9	A:A:F223	5.525	4	0	9
10	A:A:V225	4.0275	4	0	7
11	A:A:Y230	8.502	5	13	8
12	A:A:R242	8.3725	4	21	9
13	A:A:M247	5.115	4	0	6
14	A:A:F250	7.196	5	18	9
15	A:A:C254	4.9675	4	18	5
16	A:A:W258	7.038	5	0	5
17	A:A:I265	3.915	4	22	8
18	A:A:F267	4.48	4	22	9
19	A:A:L268	3.7375	4	0	8
20	A:A:Y287	7.07857	7	12	7
21	A:A:Y290	5.135	4	0	7
22	A:A:Y296	5.6525	4	0	4
23	A:A:Y302	7.485	4	12	6
24	A:A:F307	5.61	4	0	8
25	A:A:Y320	8.05	5	24	7
26	A:A:F323	5.9575	4	0	4
27	A:A:L348	3.0575	4	25	9
28	A:A:L353	5.27	5	25	7
29	B:B:L14	2.74	4	0	8
30	B:B:L30	3.5925	4	0	5
31	B:B:I37	5.24	4	0	2
32	B:B:L51	9.685	4	0	9
33	B:B:H54	9.01	6	7	9
34	B:B:I58	5.0725	4	7	9
35	B:B:Y59	10.695	4	1	8
36	B:B:W63	7.432	5	10	7
37	B:B:V71	3.798	5	3	8
38	B:B:K78	4.7325	4	0	8
39	B:B:L79	4.062	5	3	7
40	B:B:I81	4.136	5	3	7
41	B:B:W82	8.93143	7	7	9
42	B:B:N88	5.772	5	0	7
43	B:B:K89	7.688	5	7	9
44	B:B:H91	4.9925	4	3	5
45	B:B:I93	6.4175	4	3	7
46	B:B:L95	5.408	5	3	8
47	B:B:W99	7.97	6	1	9
48	B:B:Y105	4.46857	7	3	6
49	B:B:N110	4.7725	4	19	4
50	B:B:Y111	6.1325	4	19	4
51	B:B:C114	4.3425	4	3	8
52	B:B:L117	4.244	5	1	9
53	B:B:I123	4.5275	4	0	6
54	B:B:Y124	5.408	5	3	6
55	B:B:L126	4.185	4	3	5
56	B:B:V133	5.765	4	3	4
57	B:B:H142	6.9425	4	1	9
58	B:B:Y145	4.56875	8	1	8
59	B:B:C149	3.365	4	1	8
60	B:B:R150	6.0575	4	0	6
61	B:B:L152	5.95	4	2	3
62	B:B:D154	5.7475	4	19	6
63	B:B:Q156	5.2175	4	0	5
64	B:B:I157	4.3425	4	1	7
65	B:B:V158	4.554	5	2	5
66	B:B:T159	4.45333	6	1	9
67	B:B:S161	7.8025	4	1	9
68	B:B:D163	6.992	5	1	9
69	B:B:T165	4.9075	4	1	7
70	B:B:C166	4.585	4	2	8
71	B:B:L168	4.698	5	2	6
72	B:B:W169	7.58857	7	1	8
73	B:B:F180	6.95833	6	2	7
74	B:B:H183	6.88	6	2	9
75	B:B:D186	4.418	5	1	9
76	B:B:V187	5.4925	4	2	9
77	B:B:L190	4.91	4	2	5
78	B:B:F199	8.76	5	2	9
79	B:B:V200	7.8525	4	4	6
80	B:B:S201	4.915	4	2	9
81	B:B:K209	7.75	5	2	6
82	B:B:W211	7.78667	6	2	8
83	B:B:C218	4.445	4	2	5
84	B:B:H225	7.70143	7	4	9
85	B:B:D228	7.336	5	1	9
86	B:B:I232	4.696	5	4	8
87	B:B:F234	4.968	5	4	5
88	B:B:F235	7.09714	7	15	6
89	B:B:F241	6.53571	7	4	6
90	B:B:T243	5.9375	4	4	8
91	B:B:D247	4.8025	4	0	9
92	B:B:T249	3.5625	4	4	6
93	B:B:R251	11.232	5	4	8
94	B:B:F253	6.22667	6	4	6
95	B:B:Q259	4.4125	4	0	6
96	B:B:M262	5.435	4	0	4
97	B:B:Y264	6.645	4	0	5
98	B:B:R283	7.7575	4	0	9
99	B:B:L285	4.422	5	0	6
100	B:B:Y289	8.01833	6	16	7
101	B:B:N295	9.4	4	16	6
102	B:B:W297	7.9975	4	16	8
103	B:B:R304	9.2175	4	16	5
104	B:B:H311	7.736	5	14	9
105	B:B:L318	4.18	4	0	6
106	B:B:W332	11.672	5	0	9
107	B:B:K337	7.41	4	14	6
108	B:B:W339	8.94	6	14	9
109	G:G:L19	2.395	4	2	9
110	G:G:R27	6.82	4	0	8
111	G:G:Y40	8.4475	4	15	6
112	G:G:D48	7.178	5	17	9
113	G:G:L51	4.568	5	17	6
114	G:G:N59	6.435	4	9	9
115	G:G:P60	8.78	4	9	9
116	G:G:F61	5.57625	8	9	8
117	L:L:E31	5.4575	4	11	0
118	L:L:Y40	9.9	4	0	0
119	L:L:H60	4.408	5	26	0
120	L:L:C61	6.3725	4	26	0
121	L:L:D72	8.1475	4	27	0
122	L:L:R74	7.88	4	27	0
123	L:L:P80	4.5275	4	28	0
124	L:L:W84	10.3375	4	0	0
125	R:R:Y86	5.954	5	0	7
126	R:R:L101	4.248	5	20	8
127	R:R:W104	5.585	4	0	6
128	R:R:K108	3.8	4	0	5
129	R:R:W112	7.31	4	0	9
130	R:R:V128	3.8625	4	0	5
131	R:R:N129	5.8025	4	0	8
132	R:R:F130	10.625	4	5	7
133	R:R:Y131	7.65143	7	5	7
134	R:R:I134	4.9025	4	5	8
135	R:R:L137	5.845	4	0	8
136	R:R:R144	9.6025	4	0	9
137	R:R:Y145	6.326	5	6	8
138	R:R:I148	3.29	4	0	8
139	R:R:K158	5.83	4	30	6
140	R:R:V162	4.4025	4	0	7
141	R:R:W170	5.7325	4	0	9
142	R:R:R184	11.106	5	31	5
143	R:R:Y197	7.29	4	0	3
144	R:R:D199	4.8425	4	0	4
145	R:R:Q216	7.3175	4	5	5
146	R:R:F218	3.77	4	5	4
147	R:R:Y231	6.624	5	6	9
148	R:R:M243	4.62167	6	0	4
149	R:R:F260	6.1075	4	5	9
150	R:R:W264	7.99571	7	5	8
151	R:R:Y267	8.306	5	0	7
152	R:R:M277	3.065	4	0	4
153	R:R:R278	5.252	5	11	4
154	R:R:R289	10.185	4	11	3
155	R:R:H306	8.035	4	5	9
156	R:R:N310	7.39	4	0	9
157	R:R:Y314	8.0775	4	6	9
158	R:R:F321	4.2225	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:M325	G:G:P49	13.8379	6.71	No	No	0	5	7
2	G:G:D48	G:G:P49	14.4478	8.05	Yes	No	0	9	7
3	G:G:D48	G:G:L51	15.0531	9.5	Yes	Yes	17	9	6
4	B:B:R283	G:G:L51	16.1514	7.29	Yes	Yes	0	9	6
5	B:B:I37	B:B:R283	25.0959	6.26	Yes	Yes	0	2	9
6	B:B:I37	B:B:T34	34.923	6.08	Yes	No	0	2	5
7	B:B:L30	B:B:T34	35.3538	2.95	Yes	No	0	5	5
8	B:B:L30	B:B:M262	37.324	7.07	Yes	Yes	0	5	4
9	B:B:M262	B:B:Y264	38.4172	8.38	Yes	Yes	0	4	5
10	B:B:W297	B:B:Y264	44.0843	5.79	Yes	Yes	0	8	5
11	B:B:W297	B:B:Y289	44.9324	8.68	Yes	Yes	16	8	7
12	B:B:D291	B:B:Y289	47.2306	4.6	No	Yes	0	8	7
13	B:B:C271	B:B:D291	48.1224	3.11	No	No	0	5	8
14	B:B:C271	B:B:D290	48.3489	9.34	No	No	0	5	6
15	B:B:D290	B:B:R314	48.8156	17.87	No	No	0	6	8
16	A:A:W258	B:B:R314	16.38	4	Yes	No	0	5	8
17	A:A:H213	A:A:W258	16.7633	7.41	No	Yes	0	8	5
18	A:A:H213	B:B:Y59	33.4999	7.62	No	Yes	0	8	8
19	A:A:C214	B:B:Y59	43.6196	5.38	Yes	Yes	1	7	8
20	A:A:C214	B:B:L117	40.2856	3.17	Yes	Yes	1	7	9
21	A:A:W211	B:B:L117	64.2126	5.69	Yes	Yes	0	9	9
22	A:A:I212	A:A:W211	100	3.52	No	Yes	0	8	9
23	A:A:F259	A:A:I212	99.9695	5.02	No	No	0	9	8
24	A:A:F259	A:A:T262	99.7703	5.19	No	No	23	9	7
25	A:A:D261	A:A:T262	99.8464	5.78	No	No	0	4	7
26	A:A:D261	A:A:K349	99.7219	4.15	No	No	0	4	5
27	A:A:F354	A:A:K349	99.6905	4.96	No	No	0	5	5
28	A:A:F354	A:A:L348	99.5959	3.65	No	Yes	0	5	9
29	A:A:L348	A:A:L353	97.9205	4.15	Yes	Yes	25	9	7
30	A:A:L353	R:R:R144	50.3143	13.36	Yes	Yes	0	7	9
31	B:B:R314	B:B:W332	32.6855	22.99	No	Yes	0	8	9
32	A:A:H213	B:B:W332	16.6743	8.46	No	Yes	0	8	9
33	B:B:K57	B:B:W332	16.6736	15.08	No	Yes	0	9	9
34	B:B:K57	B:B:Y59	16.7502	8.36	No	Yes	0	9	8
35	A:A:F215	A:A:L37	27.0994	10.96	Yes	No	0	9	9
36	A:A:L37	A:A:L39	47.6745	8.3	No	No	0	9	9
37	A:A:V201	A:A:W211	17.5577	7.36	No	Yes	0	9	9
38	A:A:F223	A:A:L39	47.203	3.65	Yes	No	0	9	9
39	A:A:K270	A:A:L273	10.3812	2.82	No	No	0	9	6
40	A:A:E276	A:A:L273	11.3608	5.3	No	No	0	5	6
41	A:A:E275	A:A:E276	11.8525	6.34	No	No	0	5	5
42	A:A:E275	A:A:Y296	12.8359	3.37	No	Yes	0	5	4
43	A:A:F323	A:A:Y296	24.6102	3.09	Yes	Yes	0	4	4
44	A:A:F323	A:A:L268	26.565	4.87	Yes	Yes	0	4	8
45	A:A:L268	A:A:V225	14.2801	2.98	Yes	Yes	0	8	7
46	A:A:F307	A:A:V225	15.2143	5.24	Yes	Yes	0	8	7
47	A:A:F250	A:A:F307	37.7467	8.57	Yes	Yes	0	9	8
48	A:A:F223	A:A:F250	46.495	11.79	Yes	Yes	0	9	9
49	A:A:L266	A:A:L268	14.2499	4.15	No	Yes	0	9	8
50	A:A:F307	A:A:L266	15.7116	3.65	Yes	No	0	8	9
51	B:B:H62	B:B:Y105	19.5616	3.27	No	Yes	0	6	6
52	B:B:H62	B:B:R150	20.2268	12.41	No	Yes	0	6	6
53	B:B:L190	B:B:R150	20.6992	2.43	Yes	Yes	0	5	6
54	B:B:F199	B:B:L190	21.5192	9.74	Yes	Yes	2	9	5
55	B:B:F199	B:B:W211	23.5246	12.03	Yes	Yes	2	9	8
56	B:B:C218	B:B:W211	34.7678	5.22	Yes	Yes	2	5	8
57	B:B:C218	G:G:Q18	19.6291	3.05	Yes	No	2	5	9
58	G:G:L19	G:G:Q18	19.7901	1.33	Yes	No	2	9	9
59	B:B:L14	G:G:L19	39.8794	4.15	Yes	Yes	0	8	9
60	B:B:L14	B:B:Q17	42.451	1.33	Yes	No	0	8	4
61	B:B:A21	B:B:Q17	42.7706	1.52	No	No	0	4	4
62	B:B:A21	G:G:R27	42.9321	5.53	No	Yes	0	4	8
63	G:G:I25	G:G:R27	44.7382	3.76	No	Yes	0	2	8
64	B:B:Q220	G:G:I25	44.9026	5.49	No	No	0	7	2
65	B:B:F222	B:B:Q220	45.0689	9.37	No	No	0	8	7
66	B:B:F222	B:B:F253	44.7518	5.36	No	Yes	4	8	6
67	B:B:F253	B:B:H225	49.989	3.39	Yes	Yes	4	6	9
68	B:B:D247	B:B:H225	54.3103	3.78	Yes	Yes	0	9	9
69	B:B:D247	B:B:S227	56.1679	5.89	Yes	No	0	9	6
70	B:B:D228	B:B:S227	56.3047	7.36	Yes	No	1	9	6
71	A:A:K210	B:B:D228	56.0376	8.3	Yes	Yes	1	9	9
72	A:A:K210	B:B:Y145	56.6529	3.58	Yes	Yes	1	9	8
73	A:A:Q204	B:B:Y145	27.7992	5.64	No	Yes	0	9	8
74	B:B:C218	G:G:E22	19.6291	3.04	Yes	No	2	5	9
75	G:G:E22	G:G:L19	19.7901	1.33	No	Yes	2	9	9
76	A:A:M247	A:A:Y287	10.795	5.99	Yes	Yes	0	6	7
77	A:A:L353	R:R:I253	47.3448	4.28	Yes	No	0	7	7
78	B:B:D298	B:B:V40	17.4576	4.38	No	No	0	9	3
79	B:B:I43	B:B:V40	16.517	3.07	No	No	0	3	3
80	B:B:I43	B:B:M45	15.1053	2.92	No	No	0	3	4
81	B:B:L308	B:B:M45	14.6346	4.24	No	No	0	7	4
82	B:B:L308	B:B:W339	10.3873	21.64	No	Yes	0	7	9
83	B:B:G162	B:B:Y145	11.5613	5.79	No	Yes	1	9	8
84	B:B:G162	B:B:S161	12.1126	3.71	No	Yes	1	9	9
85	R:R:R144	R:R:Y231	47.1224	10.29	Yes	Yes	0	9	9
86	R:R:S141	R:R:Y231	82.9251	6.36	No	Yes	6	9	9
87	R:R:M227	R:R:S141	83.0299	6.13	No	No	0	8	9
88	R:R:F260	R:R:M227	82.8785	6.22	Yes	No	0	9	8
89	R:R:F260	R:R:W264	83.5102	7.02	Yes	Yes	5	9	8
90	R:R:F130	R:R:W264	17.9265	11.02	Yes	Yes	5	7	8
91	R:R:F130	R:R:Y131	17.3703	9.28	Yes	Yes	5	7	7
92	R:R:S173	R:R:Y131	16.812	3.82	No	Yes	0	7	7
93	R:R:S173	R:R:V128	11.4947	4.85	No	Yes	0	7	5
94	R:R:N129	R:R:V128	10.9439	4.43	Yes	Yes	0	8	5
95	R:R:I253	R:R:Y231	47.0316	6.04	No	Yes	0	7	9
96	R:R:W264	R:R:Y267	67.3564	6.75	Yes	Yes	0	8	7
97	R:R:L271	R:R:Y267	42.2319	3.52	No	Yes	0	6	7
98	R:R:L271	R:R:R212	42.2618	10.93	No	No	0	6	5
99	R:R:D274	R:R:R212	22.1775	13.1	No	No	11	4	5
100	L:L:E31	R:R:D274	21.9965	3.9	Yes	No	11	0	4
101	L:L:E31	R:R:R278	39.0532	4.65	Yes	Yes	11	0	4
102	R:R:R208	R:R:R278	57.5633	4.26	No	Yes	0	4	4
103	R:R:R208	R:R:Y197	50.8683	4.12	No	Yes	0	4	3
104	R:R:T299	R:R:Y267	24.5636	7.49	No	Yes	0	6	7
105	R:R:T299	R:R:V270	22.504	3.17	No	No	0	6	4
106	R:R:L296	R:R:V270	22.1314	2.98	No	No	0	5	4
107	L:L:E31	R:R:L296	21.9476	3.98	Yes	No	0	0	5
108	R:R:R212	R:R:T275	19.9086	6.47	No	No	11	5	4
109	R:R:M209	R:R:T275	19.7264	7.53	No	No	0	3	4
110	R:R:M209	R:R:R278	19.545	7.44	No	Yes	0	3	4
111	L:L:L32	R:R:Y197	48.3026	16.41	No	Yes	0	0	3
112	L:L:H60	L:L:L32	47.7382	5.14	Yes	No	0	0	0
113	L:L:E65	L:L:H60	43.2157	3.69	No	Yes	26	0	0
114	L:L:E65	L:L:I55	42.664	12.3	No	No	0	0	0
115	L:L:I55	L:L:R53	41.5329	2.51	No	No	0	0	0
116	L:L:I67	L:L:R53	39.8355	5.01	No	No	0	0	0
117	L:L:C77	L:L:I67	31.3366	1.64	No	No	0	0	0
118	L:L:C36	L:L:C77	30.7693	7.28	No	No	0	0	0
119	L:L:C36	L:L:T39	30.2019	1.69	No	No	0	0	0
120	L:L:D79	L:L:T39	29.6344	4.34	No	No	0	0	0
121	L:L:D79	L:L:P80	28.4991	6.44	No	Yes	0	0	0
122	L:L:P80	L:L:Q86	26.7955	3.16	Yes	No	0	0	0
123	L:L:E90	L:L:Q86	26.2275	3.82	No	No	0	0	0
124	L:L:E90	L:L:V89	25.6594	8.56	No	No	0	0	0
125	L:L:I66	L:L:V89	25.0911	1.54	No	No	0	0	0
126	L:L:I66	L:L:V68	23.9544	3.07	No	No	0	0	0
127	L:L:L78	L:L:V68	15.4176	2.98	No	No	0	0	0
128	L:L:L76	L:L:L78	14.8477	2.77	No	No	0	0	0
129	L:L:L76	L:L:Y40	14.2778	5.86	No	Yes	0	0	0
130	A:A:Q204	A:A:W211	27.9467	10.95	No	Yes	0	9	9
131	B:B:L117	B:B:Y145	37.9885	3.52	Yes	Yes	1	9	8
132	A:A:F215	A:A:W211	18.2838	4.01	Yes	Yes	0	9	9
133	A:A:L37	A:A:V201	20.8118	2.98	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:A29	R:R:K108	3.21	0	No	Yes	0	5	0	1
L:L:K30	R:R:W104	3.48	0	No	Yes	0	6	0	1
L:L:K30	R:R:Y197	3.58	0	No	Yes	0	3	0	1
L:L:E31	R:R:D274	3.9	11	Yes	No	0	4	0	1
L:L:E31	R:R:R278	4.65	11	Yes	Yes	0	4	0	1
L:L:E31	R:R:R289	9.3	11	Yes	Yes	0	3	0	1
L:L:E31	R:R:L296	3.98	11	Yes	No	0	5	0	1
L:L:L32	R:R:Y197	16.41	0	No	Yes	0	3	0	1
L:L:R33	R:R:R289	19.19	0	No	Yes	0	3	0	1
L:L:Q35	R:R:P38	14.21	0	No	No	0	7	0	1
L:L:Q35	R:R:E40	3.82	0	No	No	0	4	0	1
L:L:K38	R:R:A36	3.21	0	No	No	0	5	0	1
L:L:Y40	R:R:L34	12.89	0	Yes	No	0	2	0	1
L:L:H45	R:R:T28	6.85	0	No	No	0	7	0	1
L:L:F48	R:R:F32	8.57	0	No	No	0	3	0	1
L:L:S57	R:R:N202	5.96	0	No	No	0	2	0	1
L:L:P59	R:R:V187	5.3	0	No	No	0	3	0	1
L:L:D72	R:R:F32	4.78	27	Yes	No	0	3	0	1
L:L:R74	R:R:F32	6.41	27	Yes	No	0	3	0	1
L:L:R74	R:R:L33	4.86	27	Yes	No	0	3	0	1
L:L:R74	R:R:D35	10.72	27	Yes	No	0	6	0	1
L:L:E75	R:R:A37	6.03	0	No	No	0	7	0	1
R:R:L29	R:R:P31	9.85	0	No	No	3	5	1	2
R:R:A36	R:R:L34	4.73	0	No	No	5	2	1	1
R:R:E40	R:R:N191	7.89	0	No	No	4	2	1	2
R:R:K108	R:R:K48	4.31	0	Yes	No	5	4	1	2
R:R:K108	R:R:V51	3.04	0	Yes	No	5	5	1	2
R:R:K108	R:R:W104	4.64	0	Yes	Yes	5	6	1	1
R:R:S123	R:R:W104	4.94	0	No	Yes	5	6	2	1
R:R:K126	R:R:W104	9.28	0	No	Yes	6	6	2	1
R:R:V187	R:R:Y197	5.05	0	No	Yes	3	3	1	1
R:R:S189	R:R:V192	3.23	0	No	No	1	5	1	2
R:R:R208	R:R:Y197	4.12	0	No	Yes	4	3	2	1
R:R:R208	R:R:R278	4.26	0	No	Yes	4	4	2	1
R:R:M209	R:R:T275	7.53	0	No	No	3	4	2	2
R:R:M209	R:R:R278	7.44	0	No	Yes	3	4	2	1
R:R:D274	R:R:R212	13.1	11	No	No	4	5	1	2
R:R:R212	R:R:T275	6.47	11	No	No	5	4	2	2
R:R:L296	R:R:V270	2.98	0	No	No	5	4	1	2
R:R:D274	R:R:T275	4.34	11	No	No	4	4	1	2
R:R:M277	R:R:R289	3.72	0	Yes	Yes	4	3	2	1
R:R:R278	R:R:R289	8.53	11	Yes	Yes	4	3	1	1
L:L:K42	R:R:L29	2.82	0	No	No	0	3	0	1
L:L:H60	R:R:S189	2.79	26	Yes	No	0	1	0	1
R:R:A37	R:R:P38	1.87	0	No	No	7	7	1	1
R:R:S26	R:R:S27	1.63	0	No	No	6	7	1	2
R:R:S189	R:R:S190	1.63	0	No	No	1	2	1	2
R:R:E40	R:R:P41	1.57	0	No	No	4	4	1	2
R:R:A205	R:R:R278	1.38	0	No	Yes	1	4	2	1
L:L:R87	R:R:S26	1.32	0	No	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
63.64	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
53.85	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
53.85	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
53.33	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
50.00	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
50.00	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
47.06	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
47.06	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
46.67	Single	6OS1	TRV026	6OS1-AT₁-TRV026
46.67	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
46.67	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
46.67	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
46.67	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
45.45	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
45.45	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
45.45	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
44.44	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
44.44	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
44.44	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
43.75	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
43.75	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
43.75	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
43.75	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
43.75	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
43.75	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
43.75	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
43.75	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
43.75	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
42.86	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
42.86	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
42.86	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
42.86	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
42.86	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
42.86	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
42.86	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
41.67	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
41.67	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
41.18	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
41.18	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
41.18	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
41.18	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
41.18	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
41.18	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
41.18	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
41.18	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
40.00	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.00	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
40.00	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
40.00	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
38.89	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
38.89	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
38.89	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
38.89	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
38.89	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
38.89	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
38.46	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
38.46	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
38.46	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
38.46	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
38.46	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
38.10	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
38.10	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
38.10	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
38.10	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
38.10	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
38.10	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
37.50	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
37.50	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
37.50	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
37.50	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
37.50	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
37.50	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
37.50	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
37.50	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
36.84	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
36.84	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
36.84	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
36.84	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
36.84	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
36.84	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.36	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
36.36	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
36.36	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
35.71	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
35.71	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
35.71	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.71	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100-Cholesterol
35.71	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
35.71	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
35.71	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.29	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
35.29	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
35.29	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
35.29	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
35.29	Single	6OS2	TRV026	6OS2-AT₁-TRV026
35.29	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
35.29	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
35.29	Single	8XQJ	JN241	8XQJ-Apelin-JN241
35.29	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116-Cholesterol
35.29	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
35.29	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
35.00	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
35.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.00	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
34.78	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
34.78	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
34.78	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
34.78	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
33.33	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
33.33	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
33.33	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
33.33	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
33.33	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
33.33	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
33.33	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
33.33	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
33.33	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
33.33	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
33.33	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
33.33	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
33.33	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
33.33	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
33.33	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
32.00	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
32.00	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
32.00	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
32.00	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
32.00	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
32.00	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
32.00	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
31.82	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
31.58	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.58	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
31.58	Single	8XQJ	JN241	8XQJ-Apelin-JN241
31.58	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
30.77	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
30.77	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
30.77	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
30.77	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
30.77	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
30.77	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
30.77	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
30.77	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
30.77	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
30.77	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
30.43	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
30.43	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
30.43	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
30.43	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
30.43	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.43	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.43	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
30.00	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
30.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
30.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
30.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00	Consensus	ccr1_on	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
30.00	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
29.63	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
29.41	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
29.41	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
29.41	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
29.41	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
29.41	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
29.17	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
29.17	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
29.17	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
29.17	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.17	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
29.17	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
28.57	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
28.57	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
28.57	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
28.57	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
28.57	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
28.57	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
28.57	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
28.57	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
28.57	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
28.57	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
28.57	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.57	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
28.57	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
28.57	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
28.57	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
28.57	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
28.57	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
28.57	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
28.00	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
28.00	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
28.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
28.00	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
27.78	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
27.78	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
27.78	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
27.78	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
27.78	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
27.78	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
27.78	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.78	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.78	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
27.78	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
27.78	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
27.27	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
27.27	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
27.27	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
27.27	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
27.27	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
27.27	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
27.27	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
27.27	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
27.27	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
27.27	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
26.92	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
26.92	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
26.92	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
26.67	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
26.67	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
26.67	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
26.67	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
26.67	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
26.67	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
26.67	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
26.67	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
26.67	Consensus	hca_on	Orthosteric Ligand	hca2_on
26.32	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
26.32	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
26.32	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
26.32	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
26.32	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
26.32	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
26.32	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
26.32	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
26.32	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
26.09	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
26.09	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
26.09	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
26.09	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
26.09	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
26.09	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
26.09	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
26.09	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
26.09	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
25.93	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
25.93	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
25.93	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.93	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
25.00	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
25.00	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
25.00	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
25.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
25.00	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
25.00	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
25.00	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
25.00	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
25.00	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
25.00	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
25.00	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
25.00	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
25.00	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
25.00	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
25.00	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
25.00	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
25.00	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
25.00	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
25.00	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
25.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
25.00	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
25.00	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
25.00	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
25.00	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
25.00	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
25.00	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
25.00	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
25.00	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
25.00	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
25.00	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
25.00	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
25.00	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
25.00	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
25.00	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
25.00	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
24.00	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
24.00	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
24.00	Single	6FJ3	PTH	6FJ3-PTH1-PTH
24.00	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
24.00	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
24.00	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
23.81	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
23.81	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
23.81	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
23.81	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
23.81	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
23.81	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
23.81	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
23.81	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.53	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
23.53	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
23.53	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
23.53	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
23.53	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
23.53	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
23.53	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
23.53	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
23.53	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
23.53	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
23.53	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.53	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
23.53	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
23.53	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
23.53	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
23.33	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
23.08	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
23.08	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
23.08	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
23.08	Single	7V6A	-	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
23.08	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
23.08	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
23.08	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
23.08	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.73	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
22.73	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
22.73	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
22.73	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.73	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
22.73	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
22.73	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.73	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
22.73	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
22.73	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
22.73	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
22.73	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
22.73	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
22.73	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
22.22	Single	5V56	TC114	5V56-SMO-TC114
22.22	Single	5V57	TC114	5V57-SMO-TC114
22.22	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
22.22	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
22.22	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
22.22	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
22.22	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.22	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
22.22	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
22.22	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
22.22	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
22.22	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.22	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.22	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
22.22	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
22.22	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
22.22	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
22.22	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
22.22	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.22	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
22.22	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
21.74	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
21.74	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.74	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
21.74	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
21.74	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
21.74	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
21.74	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
21.74	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
21.74	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
21.43	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
21.43	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
21.43	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
21.43	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
21.43	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
21.43	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
21.43	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
21.43	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
21.43	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
21.43	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
21.05	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
21.05	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
21.05	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
21.05	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
21.05	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
21.05	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
21.05	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
21.05	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
21.05	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
21.05	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
21.05	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
21.05	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
21.05	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
21.05	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
21.05	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
21.05	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
21.05	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.05	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
21.05	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
21.05	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
20.83	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
20.83	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
20.83	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
20.83	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
20.83	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
20.83	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
20.69	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
20.69	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.00	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
20.00	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
20.00	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
20.00	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
20.00	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
20.00	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
20.00	Single	7EZC	UKA	7EZC-A_2A-UKA
20.00	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
20.00	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
20.00	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
20.00	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
20.00	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
20.00	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
20.00	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
20.00	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
20.00	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
20.00	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
20.00	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
20.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
20.00	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
20.00	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
20.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.00	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
20.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
20.00	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.00	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
20.00	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
20.00	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
20.00	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
20.00	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
20.00	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
20.00	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.00	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
20.00	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
20.00	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
20.00	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
20.00	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
20.00	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
20.00	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
20.00	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
20.00	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
20.00	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
20.00	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
20.00	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
19.23	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
19.23	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
19.23	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
19.23	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
19.05	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
19.05	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
19.05	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
19.05	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
19.05	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
19.05	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
19.05	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
19.05	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
19.05	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
19.05	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
19.05	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
19.05	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.05	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
18.75	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
18.75	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
18.75	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.75	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
18.75	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
18.75	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
18.75	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
18.75	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
18.75	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
18.75	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
18.75	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
18.75	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
18.75	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
18.75	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
18.75	Single	8K9L	Damgo	8K9L-μ-Damgo-VV9-Gi3/β1/γ1
18.75	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
18.75	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070-Cholesterol
18.52	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
18.52	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
18.52	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
18.52	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.52	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.18	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.18	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.18	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
18.18	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
18.18	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
18.18	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
18.18	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
18.18	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
18.18	Single	8WKY	PG-934	8WKY-MC₄-PG-934
18.18	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
18.18	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
18.18	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
18.18	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
18.18	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.18	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.18	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
18.18	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
17.86	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
17.86	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
17.86	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
17.86	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
17.86	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
17.65	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
17.65	Single	6D27	CAY10471	6D27-DP₂-CAY10471
17.65	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
17.65	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
17.65	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
17.65	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
17.65	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
17.65	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
17.65	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.65	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
17.65	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
17.65	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
17.65	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
17.65	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
17.65	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
17.65	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
17.65	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
17.65	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
17.65	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
17.65	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
17.65	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
17.65	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
17.65	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
17.65	Consensus	a3_on	Orthosteric Ligand	a3a_on
17.65	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
17.65	Consensus	cck_off	Orthosteric Ligand	ccka_off
17.65	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
17.65	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
17.39	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
17.39	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
17.39	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
17.39	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
17.39	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
17.39	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.39	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
17.39	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
17.39	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
17.39	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.39	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
17.39	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
17.39	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.39	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.24	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
16.67	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
16.67	Single	5C1M	BU72	5C1M-μ-BU72
16.67	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
16.67	Single	5N2S	PSB36	5N2S-A₁-PSB36
16.67	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
16.67	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
16.67	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
16.67	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
16.67	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
16.67	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
16.67	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
16.67	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
16.67	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
16.67	Single	7C4S	S1P	7C4S-S1P₃-S1P
16.67	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
16.67	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
16.67	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
16.67	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
16.67	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.67	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
16.67	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
16.67	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
16.67	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
16.67	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
16.67	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
16.67	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
16.67	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
16.67	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
16.67	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
16.67	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
16.67	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
16.67	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
16.67	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
16.67	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
16.67	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
16.67	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
16.67	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
16.67	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
16.67	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
16.67	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
16.67	Consensus	dp_off	Orthosteric Ligand	dp2_off
16.67	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
16.67	Consensus	ep_off	Orthosteric Ligand	ep4_off
16.67	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
16.67	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
16.67	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
16.67	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
16.67	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
16.67	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
16.67	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
16.67	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
16.13	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.00	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
16.00	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
16.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
16.00	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.00	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
16.00	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
16.00	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
16.00	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.79	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
15.79	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
15.79	Single	5TZR	MK8666	5TZR-FFA1-MK8666
15.79	Single	5XR8	AM841	5XR8-CB₁-AM841
15.79	Single	5XRA	AM11542	5XRA-CB₁-AM11542
15.79	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
15.79	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
15.79	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
15.79	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
15.79	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
15.79	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
15.79	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.79	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.79	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.79	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
15.79	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
15.79	Single	8E0G	BU72	8E0G-μ-BU72
15.79	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
15.79	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
15.79	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
15.79	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
15.79	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
15.79	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
15.79	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
15.79	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.79	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
15.79	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
15.79	Consensus	a2_on	Orthosteric Ligand	a2b_on
15.79	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
15.79	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
15.79	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
15.79	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
15.79	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
15.79	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.79	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.79	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
15.79	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
15.79	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
15.79	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
15.79	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
15.79	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
15.79	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
15.79	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
15.79	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
15.62	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
15.38	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.38	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.38	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
15.38	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
15.38	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
15.38	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
15.38	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.38	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
15.38	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
15.38	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
15.38	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
15.38	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.38	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
15.38	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
15.00	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
15.00	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1-MK8666; PubChem 127053597
15.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
15.00	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
15.00	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
15.00	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
15.00	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
15.00	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
15.00	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
15.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
15.00	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
15.00	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
15.00	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
15.00	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
15.00	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
15.00	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
15.00	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
15.00	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
15.00	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.00	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.00	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
15.00	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
15.00	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
15.00	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
15.00	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
15.00	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
15.00	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
15.00	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
14.81	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.81	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
14.81	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
14.81	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
14.81	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
14.81	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
14.81	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
14.29	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
14.29	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
14.29	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
14.29	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
14.29	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
14.29	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
14.29	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
14.29	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
14.29	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
14.29	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
14.29	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
14.29	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
14.29	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
14.29	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
14.29	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
14.29	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
14.29	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
14.29	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
14.29	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
14.29	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
14.29	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.29	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
14.29	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
14.29	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
14.29	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.29	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
14.29	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
14.29	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
14.29	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.29	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
13.79	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
13.79	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
13.79	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
13.79	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.79	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
13.79	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
13.79	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
13.64	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
13.64	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
13.64	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
13.64	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
13.64	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
13.64	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
13.64	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.64	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
13.64	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
13.64	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.64	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.64	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
13.64	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
13.64	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
13.33	Single	6LI0	C17	6LI0-GPR52-C17
13.33	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
13.33	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.33	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
13.33	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
13.33	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
13.33	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
13.33	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
13.33	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
13.33	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
13.33	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
13.33	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.33	Single	9B9Y	7DY	9B9Y-CB₁-7DY
13.33	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.33	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
13.33	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
13.04	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
13.04	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
13.04	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
13.04	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
13.04	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.04	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.04	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
13.04	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
13.04	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.04	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
13.04	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
13.04	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.04	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.04	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
13.04	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
12.90	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
12.90	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.90	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.50	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
12.50	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
12.50	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
12.50	Single	5U09	Taranabant	5U09-CB₁-Taranabant
12.50	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
12.50	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
12.50	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
12.50	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
12.50	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.50	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.50	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
12.50	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
12.50	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
12.50	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
12.50	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.50	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.50	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.50	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.50	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
12.50	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
12.50	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
12.50	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
12.50	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
12.50	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
12.50	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
12.50	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
12.50	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
12.50	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.50	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
12.50	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
12.50	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.50	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
12.50	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.50	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
12.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
12.12	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
12.12	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
12.00	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
12.00	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
12.00	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
12.00	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.00	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
12.00	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.76	Single	3REY	XAC	3REY-A_2A-XAC
11.76	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
11.76	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
11.76	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
11.76	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
11.76	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
11.76	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
11.76	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
11.76	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
11.76	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
11.76	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
11.76	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
11.76	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
11.76	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
11.76	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
11.76	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
11.76	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
11.76	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
11.76	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
11.76	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
11.76	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
11.76	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
11.76	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
11.76	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
11.76	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
11.76	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
11.76	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
11.76	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
11.76	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
11.76	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
11.76	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
11.76	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
11.76	Consensus	a2_off	Orthosteric Ligand	a2a_off
11.76	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
11.76	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
11.76	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
11.76	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
11.76	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
11.54	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
11.54	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
11.54	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
11.54	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.54	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
11.54	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
11.54	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.54	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
11.54	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.54	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
11.54	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.54	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
11.54	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
11.54	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
11.54	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
11.11	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
11.11	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
11.11	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
11.11	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
11.11	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
11.11	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
11.11	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
11.11	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
11.11	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
11.11	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
11.11	Single	5UEN	DU172	5UEN-A₁-DU172
11.11	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
11.11	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
11.11	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
11.11	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
11.11	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
11.11	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
11.11	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
11.11	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
11.11	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
11.11	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
11.11	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
11.11	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
11.11	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
11.11	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
11.11	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
11.11	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
11.11	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
11.11	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
11.11	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
11.11	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
11.11	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
11.11	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
11.11	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
11.11	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
11.11	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
11.11	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
11.11	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
11.11	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.11	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
11.11	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
11.11	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
11.11	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
11.11	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
11.11	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
11.11	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
11.11	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
11.11	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
11.11	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
11.11	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
11.11	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.11	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
11.11	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
11.11	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.11	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.11	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
11.11	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
11.11	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
11.11	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
11.11	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
11.11	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
11.11	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
11.11	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
11.11	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
11.11	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
11.11	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
11.11	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
11.11	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
11.11	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.11	Single	7XW7	K1-70	7XW7-TSH-K1-70
11.11	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.11	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
11.11	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
11.11	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
11.11	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
11.11	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
11.11	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
11.11	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
11.11	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
11.11	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
11.11	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
11.11	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
11.11	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
11.11	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
11.11	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
11.11	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
11.11	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
11.11	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
11.11	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
11.11	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
11.11	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
11.11	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
11.11	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
11.11	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
11.11	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
11.11	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
11.11	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
11.11	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
11.11	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
11.11	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
11.11	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
11.11	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
11.11	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.11	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.11	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
11.11	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11	Single	8T1W	CVN424	8T1W-GPR6-CVN424
11.11	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
11.11	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
11.11	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
11.11	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
11.11	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.11	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
11.11	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
11.11	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
11.11	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
11.11	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
11.11	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
11.11	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
11.11	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
11.11	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
11.11	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
11.11	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
11.11	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
11.11	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
11.11	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
11.11	Single	8WGD	WAG/WA6	8WGD-mGlu4; mGlu2-WAG/WA6
11.11	Single	8WGD	WAG/WA6	8WGD-mGlu4; mGlu2-WAG/WA6
11.11	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11	Single	8WVX	Norrin	8WVX-LGR4-Norrin
11.11	Single	8WVY	Norrin	8WVY-LGR4-Norrin
11.11	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.11	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
11.11	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
11.11	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
11.11	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
11.11	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
11.11	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
11.11	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
11.11	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
11.11	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
11.11	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
11.11	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
11.11	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
11.11	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
11.11	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
11.11	Consensus	blt_on	Orthosteric Ligand	blt1_on
11.11	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
11.11	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
11.11	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
11.11	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
11.11	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.71	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
10.71	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
10.53	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
10.53	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
10.53	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
10.53	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
10.53	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
10.53	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
10.53	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
10.53	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
10.53	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
10.53	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
10.53	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
10.53	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
10.53	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
10.53	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
10.53	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
10.53	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
10.53	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
10.53	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
10.53	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
10.53	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.53	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
10.53	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
10.53	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.53	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
10.53	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
10.53	Single	8WGB	W9R	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
10.53	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go1/β1/γ2
10.53	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
10.53	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
10.53	Consensus	blt_off	Orthosteric Ligand	blt1_off
10.53	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
10.53	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
10.53	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
10.53	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
10.34	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
10.00	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.00	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
10.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
10.00	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
10.00	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
10.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
10.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.00	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
10.00	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
10.00	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
10.00	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
10.00	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
10.00	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
10.00	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
10.00	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
10.00	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
10.00	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
10.00	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
10.00	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
10.00	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
10.00	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
10.00	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
10.00	Single	9GE2	ML184	9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
10.00	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.00	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
10.00	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
10.00	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
10.00	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
10.00	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
9.68	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.68	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
9.68	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.68	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.68	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
9.68	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
9.68	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
9.52	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
9.52	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
9.52	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
9.52	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
9.52	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
9.52	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.52	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
9.52	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
9.52	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
9.52	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.52	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
9.52	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
9.52	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
9.52	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
9.52	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
9.52	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
9.52	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
9.52	Single	8JWY	2-118	8JWY-A_2A-2-118
9.52	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
9.52	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
9.52	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
9.52	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
9.52	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
9.52	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
9.52	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
9.52	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
9.52	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.52	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
9.52	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
9.52	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
9.52	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
9.52	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.52	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.52	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
9.52	Consensus	orexin_on	Orthosteric Ligand	ox2_on
9.52	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.38	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
9.38	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.38	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
9.09	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
9.09	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
9.09	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
9.09	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
9.09	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
9.09	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
9.09	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
9.09	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
9.09	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
9.09	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
9.09	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
9.09	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
9.09	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
9.09	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
9.09	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
9.09	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
9.09	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
9.09	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
9.09	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
8.82	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.82	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.82	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
8.70	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
8.70	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
8.70	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.70	Single	6PT3	DPI-287	6PT3-δ-DPI-287
8.70	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
8.70	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
8.70	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
8.70	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.70	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
8.57	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.33	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
8.33	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
8.33	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
8.33	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
8.33	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.33	Single	7QA8	Peptide	7QA8-STE2-Peptide
8.33	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
8.33	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
8.33	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
8.33	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
8.33	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
8.33	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
8.33	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
8.33	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
8.33	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
8.33	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
8.33	Single	8XOF	Lys05	8XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.00	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
8.00	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
8.00	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.89	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.69	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
7.69	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
7.69	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
7.69	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
7.69	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
7.69	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.69	Single	8HS2	Fab046	8HS2-GPR20-Fab046
7.69	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
7.69	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
7.69	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
7.41	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
7.41	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
7.41	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
7.41	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
7.41	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
7.14	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
7.14	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
7.14	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
7.14	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
7.14	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.14	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
7.14	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.90	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
6.90	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.90	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
6.67	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
6.67	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
6.67	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
6.67	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
6.67	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.67	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.67	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
6.67	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.67	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
6.67	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
6.67	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
6.67	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
6.67	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.67	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.67	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.67	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.67	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.67	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.45	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.45	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
6.45	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
6.45	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
6.25	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
6.25	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
6.25	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
6.25	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.25	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
6.25	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
6.25	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
6.25	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
6.25	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
6.25	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
6.25	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.25	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
6.25	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
6.25	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
6.25	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
6.25	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
6.25	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
6.25	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
6.25	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
5.88	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.88	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.88	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
5.88	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
5.88	Single	5WS3	EMPA	5WS3-OX₂-EMPA
5.88	Single	6AKX	A4R	6AKX-CCR5-A4R
5.88	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
5.88	Single	6B73	MP1104	6B73-κ-MP1104
5.88	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
5.88	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
5.88	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.88	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
5.88	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
5.88	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
5.88	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.88	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.88	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
5.88	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
5.88	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/β1/γ2
5.88	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.88	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
5.88	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.88	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.88	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
5.88	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
5.88	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.88	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
5.88	Consensus	angiotensin_off	Orthosteric Ligand	at1_off
5.88	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
5.88	Consensus	ox1_off	Orthosteric Ligand	6TP6-OX₁-Filorexant 6TP4-OX₁-ACT-462206 6V9S-OX₁-GTPL11403 6TOT-OX₁-Lemborexant 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant 6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na
5.88	Consensus	ox2_off	Orthosteric Ligand	5WQC-OX₂-EMPA 6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant 6TPJ-OX₂-Suvorexant
5.88	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.56	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.56	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
5.56	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
5.56	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
5.56	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.56	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
5.56	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
5.56	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
5.56	Single	6IQL	L745870	6IQL-D₄-L745870
5.56	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
5.56	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.56	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
5.56	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
5.56	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
5.56	Single	6TPG	EMPA	6TPG-OX₂-EMPA
5.56	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
5.56	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
5.56	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
5.56	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.56	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
5.56	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
5.56	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
5.56	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
5.56	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.56	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
5.56	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
5.56	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
5.56	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
5.56	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
5.56	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
5.56	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
5.56	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.56	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
5.56	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
5.56	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
5.56	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
5.56	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.56	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
5.56	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
5.56	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
5.56	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.56	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
5.56	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
5.56	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
5.56	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
5.56	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
5.56	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
5.56	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.56	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.26	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
5.26	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
5.26	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
5.26	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
5.26	Single	5DHG	C-35	5DHG-NOP-C-35
5.26	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
5.26	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
5.26	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
5.26	Single	6GPS	MK0812	6GPS-CCR2-MK0812
5.26	Single	6IIV	Daltroban	6IIV-TP-Daltroban
5.26	Single	6PS1	Timolol	6PS1-β₂-Timolol
5.26	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
5.26	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
5.26	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
5.26	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
5.26	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
5.26	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
5.26	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
5.26	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
5.26	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
5.26	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
5.26	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.26	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
5.26	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
5.26	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
5.26	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.26	Single	8JXR	LSD	8JXR-D₁-LSD
5.26	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
5.26	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
5.26	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
5.26	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
5.26	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.26	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
5.26	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.26	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
5.26	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
5.26	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
5.26	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
5.26	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.26	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
5.26	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
5.26	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
5.26	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
5.26	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
5.00	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
5.00	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
5.00	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
5.00	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
5.00	Single	5WQC	EMPA	5WQC-OX₂-EMPA
5.00	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
5.00	Single	6GPX	MK0812	6GPX-CCR2-MK0812
5.00	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
5.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
5.00	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
5.00	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
5.00	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
5.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.00	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.00	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.00	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
5.00	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/β1/γ2
5.00	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
5.00	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
5.00	Single	7W41	PD176252	7W41-BB₂-PD176252
5.00	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
5.00	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
5.00	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.00	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
5.00	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
5.00	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
5.00	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
5.00	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
5.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.00	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
5.00	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.00	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
5.00	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
5.00	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
5.00	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
5.00	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go1/β1/γ2
5.00	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
5.00	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
5.00	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
5.00	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
5.00	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
5.00	Consensus	d4_on	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.00	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
5.00	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
4.76	Single	2YDV	NECA	2YDV-A_2A-NECA
4.76	Single	3P0G	BI167107	3P0G-β₂-BI167107
4.76	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
4.76	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
4.76	Single	4DJH	JDTic	4DJH-κ-JDTic
4.76	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
4.76	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.76	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.76	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.76	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
4.76	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.76	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
4.76	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
4.76	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
4.76	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.76	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.76	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
4.76	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
4.76	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
4.76	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
4.76	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
4.76	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
4.76	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.76	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
4.76	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
4.76	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
4.76	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
4.76	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
4.76	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.76	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
4.76	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
4.76	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go1/β1/γ2
4.76	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
4.76	Consensus	d4_on_gp	Orthosteric Ligand	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.76	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
4.76	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
4.76	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.76	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
4.55	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
4.55	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.55	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.55	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
4.55	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.55	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
4.55	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
4.55	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
4.55	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.55	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.55	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
4.55	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
4.55	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
4.55	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
4.55	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.55	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.55	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.55	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.55	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.55	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
4.35	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.35	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.35	Single	5X93	K-8794	5X93-ET_B-K-8794
4.35	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.35	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.35	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.35	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
4.35	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.35	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
4.35	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
4.35	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
4.35	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
4.35	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.35	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.35	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.35	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.35	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
4.35	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.35	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
4.35	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.35	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
4.35	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.35	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.35	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
4.17	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
4.17	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
4.17	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
4.17	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.17	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
4.00	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
4.00	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
4.00	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
4.00	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
4.00	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
4.00	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
4.00	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
4.00	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
4.00	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
3.85	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
3.70	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
3.70	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
3.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.57	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.57	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
3.23	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
3.23	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB	6LFO
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR2
Species	Homo Sapiens
Ligand	Interleukin-8
Other Ligand(s)	-
Protein Partners	Gi1/Beta1/Gamma2
PDB Resolution	3.4
Date	2020-09-02
D.O.I.	10.1038/s41586-020-2492-5

Net Summary
I_min	2.95
Number of Linked Nodes	940
Number of Links	1103
Number of Hubs	158
Number of Links mediated by Hubs	581
Number of Communities	31
Number of Nodes involved in Communities	207
Number of Links involved in Communities	288

Path Summary
Number Of Nodes in MetaPath	134
Number Of Links MetaPath	133
Number of Shortest Paths	3384291
Length Of Smallest Path	3
Average Path Length	40.0655
Length of Longest Path	80
Minimum Path Strength	1.185
Average Path Strength	6.13456
Maximum Path Strength	20.545
Minimum Path Correlation	0.7
Average Path Correlation	0.99278
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.17391
Average % Of Corr. Nodes	42.669
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.5346
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • molecular function activator activity • signaling receptor binding • signaling receptor activity • G protein-coupled receptor binding • signaling receptor activator activity • cytokine receptor binding • chemokine activity • molecular function regulator activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CXCR chemokine receptor binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • interleukin-8 receptor binding • cell adhesion • regulation of cell adhesion • positive chemotaxis • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • positive regulation of biological process • response to external stimulus • induction of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • digestive system development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • neutrophil activation • immune system process • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • neutrophil chemotaxis • neutrophil migration • granulocyte migration • leukocyte migration • granulocyte chemotaxis • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • biological process involved in interspecies interaction between organisms • entry of bacterium into host cell • regulation of entry of bacterium into host cell • symbiont entry into host • modulation by symbiont of entry into host • biological process involved in interaction with host • biological process involved in symbiotic interaction • regulation of biological process involved in symbiotic interaction • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • regulation of cell motility • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of immune system process • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of granulocyte chemotaxis • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • calcium-mediated signaling • response to fibroblast growth factor • cellular response to growth factor stimulus • response to growth factor • cellular response to fibroblast growth factor stimulus • regulation of cell adhesion molecule production • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell adhesion molecule production • cell adhesion molecule production • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • humoral immune response • defense response • immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • inflammatory response • regulation of signaling • negative regulation of signaling • negative regulation of response to stimulus • regulation of signal transduction • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • regulation of single stranded viral RNA replication via double stranded DNA intermediate • RNA metabolic process • viral life cycle • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • regulation of RNA metabolic process • viral RNA genome replication • viral process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • primary metabolic process • nucleobase-containing compound biosynthetic process • single stranded viral RNA replication via double stranded DNA intermediate • nucleic acid metabolic process • regulation of viral life cycle • regulation of viral process • viral genome replication • regulation of viral genome replication • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • cellular response to interleukin-1 • response to interleukin-1 • cellular response to stress • response to endoplasmic reticulum stress • G protein-coupled chemoattractant receptor activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • chemokine binding • C-X-C chemokine binding • interleukin-8 binding • cytokine binding • C-C chemokine binding • head development • brain development • nervous system development • central nervous system development • midbrain development • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • acute inflammatory response to antigenic stimulus • acute inflammatory response • inflammatory response to antigenic stimulus • homeostatic process • leukocyte apoptotic process • regulation of programmed cell death • regulation of neutrophil apoptotic process • negative regulation of leukocyte apoptotic process • negative regulation of neutrophil apoptotic process • myeloid cell homeostasis • regulation of leukocyte apoptotic process • myeloid cell apoptotic process • negative regulation of programmed cell death • regulation of apoptotic process • cell death • neutrophil homeostasis • neutrophil apoptotic process • negative regulation of apoptotic process • multicellular organismal-level homeostasis • leukocyte homeostasis • inflammatory cell apoptotic process • negative regulation of myeloid cell apoptotic process • homeostasis of number of cells • apoptotic process • programmed cell death • regulation of myeloid cell apoptotic process • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • positive regulation of cell population proliferation • dendritic cell chemotaxis • dendritic cell migration • mononuclear cell migration • cell surface receptor signaling pathway • regulation of vascular permeability • circulatory system process • positive regulation of vascular permeability • vascular process in circulatory system • blood circulation • cellular defense response • epithelium development • kidney epithelium development • metanephric tubule morphogenesis • morphogenesis of an epithelium • metanephric epithelium development • tissue development • renal system development • tissue morphogenesis • metanephros development • metanephric tubule development • epithelial tube morphogenesis • kidney development • cytokine-mediated signaling pathway • cellular response to interleukin-8 • response to interleukin-8 • interleukin-8-mediated signaling pathway • cell surface • external side of plasma membrane • mast cell granule • mitotic spindle • spindle • intracellular vesicle • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63096
Sequence	>6LFO_Chain_A C T L S A E D K A A V E R S K M I D R N L R E D G E K A A R E V K L L L L G A G E S G K S T I V K Q M K I I V K T T G I V E T H F T F K D L H F K M F D V G G Q R S E R K K W I H C F E G V T A I I F C V A L S D Y D L V L A E D E E M N R M H E S M K L F D S I C N N K W F T D T S I I L F L N K K D L F E E K I K K S P L T I C Y P E Y A G S N T Y E E A A A Y I Q C Q F E D L N K R K D T K E I Y T H F T C A T D T K N V Q F V F D A V T D V I I K N N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>6LFO_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>6LFO_Chain_G A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P25025
Sequence	>6LFO_Chain_R S S T L P P F L L D A A P C E P E S L E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R Y L V K F I C L S I W G L S L L L A L P V L L F R R T V Y S S N V S P A C Y E D M G N N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K F R H G L L K I L A I H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XWS	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	-	3.06	2025-01-15	To be published
	8XWN	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	-	3.29	2025-01-15	To be published
	8XWM	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	-	3.71	2025-01-15	To be published
	8XWF	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	-	3.65	2025-01-15	To be published
	8XWA	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	-	3.48	2025-01-15	To be published
	8XVU	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	-	3.09	2025-01-15	To be published
	8XXX	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXX (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL6	-		3.17	2025-01-15	To be published
	8XXR	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-	Go/β1/γ2	3.17	2025-01-15	To be published
	8XXR (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	-	-		3.17	2025-01-15	To be published
	8XXH	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-	Go/β1/γ2	2.8	2025-01-15	To be published
	8XXH (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL2	-		2.8	2025-01-15	To be published
	8XX7	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-	Go/β1/γ2	3.32	2025-01-15	To be published
	8XX7 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL5	-		3.32	2025-01-15	To be published
	8XX6	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-	Go/β1/γ2	2.99	2025-01-15	To be published
	8XX6 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL8	-		2.99	2025-01-15	To be published
	8XX3	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-	Go/β1/γ2	3.38	2025-01-15	To be published
	8XX3 (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL3	-		3.38	2025-01-15	To be published
	8XWV	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-	Go/β1/γ2	3.07	2025-01-15	To be published
	8XWV (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	CXCL1	-		3.07	2025-01-15	To be published
	6LFL	A	Protein	Chemokine	CXCR2	Homo sapiens	-	PubChem 153466996	-	3.2	2020-09-02	10.1038/s41586-020-2492-5
	6LFO	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFO (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.4	2020-09-02	10.1038/s41586-020-2492-5
	6LFM	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.5	2020-09-02	10.1038/s41586-020-2492-5
	6LFM (No Gprot)	A	Protein	Chemokine	CXCR2	Homo sapiens	Interleukin-8	-		3.5	2020-09-02	10.1038/s41586-020-2492-5

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Download 6LFO.zip

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