Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y53 5.22404
2R:R:Y61 7.94617
3R:R:L74 3.115406
4R:R:F92 5.074558
5R:R:V103 5.525417
6R:R:C107 5.5075417
7R:R:L108 6.975417
8R:R:T111 6.816517
9R:R:W120 6.87833677
10R:R:F122 6.3525406
11R:R:Q134 10.305417
12R:R:V140 8.115407
13R:R:T144 5.41407
14R:R:?147 5.785456
15R:R:R152 6.2475409
16R:R:W153 8.068528
17R:R:H158 8.84526
18R:R:M184 6.0975487
19R:R:Q187 6.744506
20R:R:F207 6.3475403
21R:R:E212 8.884514
22R:R:W214 12.412514
23R:R:Y223 7.182508
24R:R:F227 8.0475485
25R:R:F228 5.475496
26R:R:Y232 5.945498
27R:R:Y243 6.7409
28R:R:L250 3.374108
29R:R:W251 10.2345105
30R:R:Y317 6.42507
31R:R:R328 12.52414
32R:R:F333 6.184514
33R:R:R339 5.55431
34R:R:F346 6.7675414
35R:R:H350 7.062515
36R:R:W351 6.24505
37R:R:L352 4.19408
38R:R:Y354 7.19143717
39R:R:Y364 7.5775449
40R:R:F371 6.55333648
41L:L:?2 10.4189910
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F207 R:R:P198 10.68385.78YesNo032
2R:R:F207 R:R:T119 17.6185.19YesNo035
3R:R:F121 R:R:T119 19.33897.78NoNo645
4R:R:F121 R:R:F122 22.85644.29NoYes046
5R:R:F122 R:R:W120 28.024213.03YesYes067
6R:R:I130 R:R:W120 52.25844.7NoYes057
7R:R:I130 R:R:P131 55.19563.39NoNo055
8L:L:?2 R:R:P131 50.981611.52YesNo005
9L:L:?2 R:R:T111 20.14139.4YesYes107
10R:R:T111 R:R:Y61 21.35256.24YesYes177
11R:R:L57 R:R:Y61 26.49515.86NoYes057
12R:R:L57 R:R:Y53 24.30992.34NoYes054
13R:R:K51 R:R:Y53 15.468111.94NoYes044
14R:R:E118 R:R:K51 10.98668.1NoNo044
15L:L:?2 R:R:Y354 55.74064.48YesYes107
16R:R:Y354 R:R:Y61 18.98565.96YesYes177
17R:R:W351 R:R:Y61 21.43839.65YesYes057
18R:R:L108 R:R:Y354 29.94210.55YesYes177
19R:R:F65 R:R:L108 38.14796.09NoYes067
20R:R:F65 R:R:T104 36.4323.89NoNo067
21R:R:A100 R:R:N72 22.34174.69NoNo099
22R:R:A100 R:R:S357 24.13833.42NoNo099
23R:R:S357 R:R:T104 25.92483.2NoNo097
24R:R:N72 R:R:S97 15.00388.94NoNo099
25R:R:F375 R:R:L74 21.20622.44NoYes076
26R:R:F371 R:R:F375 29.01346.43YesNo087
27R:R:F371 R:R:Y364 44.71865.16YesYes489
28R:R:N360 R:R:Y364 72.74794.65NoYes099
29R:R:N356 R:R:N360 75.17544.09NoNo099
30R:R:N356 R:R:Y317 66.13174.65NoYes097
31R:R:V353 R:R:Y317 99.742610.09NoYes077
32L:L:?2 R:R:V353 1003.8YesNo007
33R:R:C76 R:R:S97 11.38031.72NoNo069
34R:R:F371 R:R:M85 13.39897.46YesNo088
35R:R:D151 R:R:R152 13.393910.72NoYes099
36R:R:R152 R:R:T89 18.1635.17YesNo098
37R:R:I93 R:R:T89 19.70223.04NoNo088
38R:R:I93 R:R:Y364 19.35414.51NoYes489
39R:R:D151 R:R:V88 11.75377.3NoNo096
40R:R:F92 R:R:T144 67.47923.89YesYes087
41R:R:L96 R:R:T144 79.3544.42NoYes097
42R:R:L145 R:R:L96 81.55446.92NoNo099
43R:R:F313 R:R:L145 82.63947.31NoNo099
44R:R:F313 R:R:Y317 86.878610.32NoYes097
45R:R:?147 R:R:F92 35.15526.22YesYes568
46R:R:F92 R:R:I148 29.10935.02YesNo588
47L:L:?2 R:R:Q134 12.586420.37YesYes107
48R:R:C107 R:R:Y354 11.15824.03YesYes177
49L:L:?2 R:R:H350 19.096611.48YesYes105
50R:R:C127 R:R:W120 19.74775.22NoYes797
51R:R:C127 R:R:C193 18.0523.64NoNo094
52R:R:Q187 R:R:T135 12.91457.09YesNo066
53L:L:?2 R:R:Q187 46.85345.94YesYes006
54R:R:F227 R:R:Y223 12.73785.16YesYes058
55R:R:Q187 R:R:Y223 23.573110.15YesYes068
56R:R:F227 R:R:T231 19.323715.56YesNo056
57R:R:V138 R:R:Y317 19.48525.05NoYes067
58R:R:T231 R:R:V138 18.23374.76NoNo066
59R:R:?147 R:R:L150 31.7899.43YesNo066
60R:R:I148 R:R:L306 30.02784.28NoNo088
61R:R:L306 R:R:Y243 27.18145.86NoYes089
62R:R:L150 R:R:Y154 17.54734.69NoNo064
63R:R:L150 R:R:L242 12.76314.15NoNo065
64R:R:Q245 R:R:W153 12.93466.57NoYes058
65R:R:I246 R:R:Y243 22.67473.63NoYes099
66R:R:I156 R:R:I246 21.12042.94NoNo089
67R:R:I156 R:R:L250 19.55592.85NoYes088
68R:R:P186 R:R:Y223 15.07444.17NoYes068
69R:R:I185 R:R:P186 12.58643.39NoNo056
70R:R:E212 R:R:Q187 15.97785.1YesYes046
71R:R:W214 R:R:Y223 11.7797.72YesYes048
72R:R:A219 R:R:W214 12.03133.89NoYes034
73R:R:Y232 R:R:Y317 17.92581.99YesYes087
74R:R:F228 R:R:Y232 11.51157.22YesYes968
75R:R:M305 R:R:Y364 10.10855.99NoYes089
76R:R:C316 R:R:N356 21.11539.45NoNo089
77R:R:L352 R:R:W351 19.22793.42YesYes085
78R:R:F346 R:R:L323 12.117113.4YesNo045
79R:R:F346 R:R:H350 22.04395.66YesYes145
80R:R:L323 R:R:W345 10.98662.28NoNo055
81R:R:F379 R:R:W383 13.39891NoNo051
82R:R:F379 R:R:L74 14.93312.44NoYes056
83R:R:I105 R:R:T106 12.63693.04NoNo045
84R:R:I105 R:R:V101 10.12873.07NoNo047
85R:R:L108 R:R:Y61 11.60234.69YesYes177
86R:R:C316 R:R:L352 20.41894.76NoYes088
87R:R:C107 R:R:T106 16.71465.07YesNo075
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L108 R:R:Y61 4.69 1 Yes Yes 7 7 2 2
R:R:T111 R:R:Y61 6.24 1 Yes Yes 7 7 1 2
R:R:Y354 R:R:Y61 5.96 1 Yes Yes 7 7 1 2
R:R:C107 R:R:V103 6.83 1 Yes Yes 7 7 2 2
R:R:Q134 R:R:V103 5.73 1 Yes Yes 7 7 1 2
R:R:V103 R:R:Y354 6.31 1 Yes Yes 7 7 2 1
R:R:C107 R:R:Q134 6.1 1 Yes Yes 7 7 2 1
R:R:C107 R:R:Y354 4.03 1 Yes Yes 7 7 2 1
R:R:L108 R:R:Y354 10.55 1 Yes Yes 7 7 2 1
R:R:D115 R:R:T111 4.34 1 No Yes 5 7 2 1
R:R:H350 R:R:T111 4.11 1 Yes Yes 5 7 1 1
R:R:T111 R:R:Y354 9.99 1 Yes Yes 7 7 1 1
L:L:?2 R:R:T111 9.4 1 Yes Yes 0 7 0 1
R:R:D115 R:R:H350 10.08 1 No Yes 5 5 2 1
R:R:I130 R:R:P131 3.39 0 No No 5 5 2 1
R:R:M191 R:R:P131 10.06 0 No No 6 5 2 1
L:L:?2 R:R:P131 11.52 1 Yes No 0 5 0 1
R:R:Q134 R:R:Y354 9.02 1 Yes Yes 7 7 1 1
L:L:?2 R:R:Q134 20.37 1 Yes Yes 0 7 0 1
R:R:Q187 R:R:T135 7.09 0 Yes No 6 6 1 2
R:R:M191 R:R:Q187 5.44 0 No Yes 6 6 2 1
R:R:E212 R:R:Q187 5.1 1 Yes Yes 4 6 2 1
R:R:Q187 R:R:Y223 10.15 0 Yes Yes 6 8 1 2
L:L:?2 R:R:Q187 5.94 1 Yes Yes 0 6 0 1
R:R:V353 R:R:Y317 10.09 0 No Yes 7 7 1 2
R:R:I320 R:R:N324 8.5 1 No No 7 7 1 1
R:R:H350 R:R:I320 3.98 1 Yes No 5 7 1 1
L:L:?2 R:R:I320 13.65 1 Yes No 0 7 0 1
L:L:?2 R:R:N324 13.13 1 Yes No 0 7 0 1
R:R:F346 R:R:H350 5.66 1 Yes Yes 4 5 2 1
L:L:?2 R:R:H350 11.48 1 Yes Yes 0 5 0 1
L:L:?2 R:R:V353 3.8 1 Yes No 0 7 0 1
L:L:?2 R:R:Y354 4.48 1 Yes Yes 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
90.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
90.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
80.00Single5WS3EMPA5WS3-OX2-EMPA
75.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
75.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
75.00Single6TP6Filorexant6TP6-OX1-Filorexant
72.73Single4ZJCSB-6740424ZJC-OX1-SB-674042
72.73Single6V9SGTPL114036V9S-OX1-GTPL11403
72.73Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
70.00Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
69.23Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
66.67Single6TOTLemborexant6TOT-OX1-Lemborexant
63.64Single6TODEMPA6TOD-OX1-EMPA-Na
63.64Single7XRRLemborexant7XRR-OX2-Lemborexant
63.64Consensusorexin_offOrthosteric Ligandox2_off ox1_off
61.54Single5WQCEMPA5WQC-OX2-EMPA
58.33Single6TPGEMPA6TPG-OX2-EMPA
58.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
58.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
58.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
57.14Single6TQ7SB-3348676TQ7-OX1-SB-334867
53.85Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
53.85Single7UL4Alvimopan7UL4-μ-Alvimopan
53.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
50.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
50.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8IWESpermidine8IWE-TAAR9-Spermidine
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Single5X93K-87945X93-ETB-K-8794
46.67Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
46.67Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
46.67Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
46.67Single8E0GBU728E0G-μ-BU72
46.67Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
46.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
46.15Single2YDOAdenosine2YDO-A2A-Adenosine
46.15Single6IQLL7458706IQL-D4-L745870
46.15Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.15Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
46.15Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
46.15Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
45.45Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
43.75Single7K15MKD0467K15-BLT1-MKD046-Na
43.75Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
43.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single7YITNalfurafine7YIT-κ-Nalfurafine
43.75Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
43.75Consensusblt_offOrthosteric Ligandblt1_off
43.75Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
43.75Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
43.75Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
42.86Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
42.86Single4YAYZD-71554YAY-AT1-ZD-7155
42.86Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single5TGZAM65385TGZ-CB1-AM6538
42.86Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
42.86Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
42.86Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
42.86Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
42.86Consensuscck_offOrthosteric Ligandccka_off
42.86Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
41.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
41.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
41.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
41.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
41.18Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
41.18Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
41.18Consensusendothelin_offOrthosteric Ligandetb_off
41.18Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
40.00Single5C1MBU725C1M-μ-BU72
40.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
40.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
40.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
40.00Single7SINNPS-21437SIN-CaS-NPS-2143
40.00Single7SINNPS-21437SIN-CaS-NPS-2143
40.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
40.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
38.89Single5ZTYAM102575ZTY-CB2-AM10257
38.89Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
38.89Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
38.89Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
38.89Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
38.46Single6AKXA4R6AKX-CCR5-A4R
38.46Single6B73PubChem 1319551386B73-κ-PubChem 131955138
38.46Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
38.46Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
38.46Single7F8ULintitript7F8U-CCKA-Lintitript
38.46Single7F8YDevazepide7F8Y-CCKA-Devazepide
38.46Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
38.46Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
38.46Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.46Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
38.46Single8IHKAcifran8IHK-HCA3-Acifran
38.46Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.46Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
38.46Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
38.46Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
38.46Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single2YDVNECA2YDV-A2A-NECA
37.50Single4DJHJDTic4DJH-κ-JDTic
37.50Single4RWADIPP-NH24RWA-δ-DIPP-NH2
37.50Single4UHRCGS216804UHR-A2A-CGS21680
37.50Single5G53NECA5G53-A2A-NECA-Gs
37.50Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
37.50Single6H7JIsoprenaline6H7J-β1-Isoprenaline
37.50Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
37.50Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
37.50Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
37.50Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
37.50Single7W41PD1762527W41-BB2-PD176252
37.50Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
37.50Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
37.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
37.50Consensusbombesin_offOrthosteric Ligandbb2_off
37.50Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
37.50Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
37.50Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
37.50Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
37.50Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
36.84Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.84Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
36.36Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
36.36Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
35.71Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
35.71Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.71Single6DS0Ly2660976DS0-5-HT2B-Ly266097
35.71Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
35.71Single6PS4ICI 118-5516PS4-β2-ICI 118-551
35.71Single6TPKRetosiban6TPK-OT-Retosiban
35.71Single6TPNHTL66416TPN-OX2-HTL6641
35.71Single6ZG9GSK10347026ZG9-M1-GSK1034702
35.71Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.71Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
35.71Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
35.71Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
35.71Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGQEpinephrine8GGQ-β2-Epinephrine
35.71Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
35.71Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
35.71Single8K5CAcipimox8K5C-HCA2-Acipimox
35.71Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.71Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
35.71Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
35.71Consensushca_onOrthosteric Ligandhca2_on hca3_on
35.71Consensushcar_onOrthosteric Ligandhca_on
35.71Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
35.71Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
35.71Consensusvasopressin-ot_offOrthosteric Ligandot_off
35.29Single4LDEBI1671074LDE-β2-BI167107
35.29Single6HLPNetupitant6HLP-NK1-Netupitant
35.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
35.29Single6ZG4HTL00099366ZG4-M1-HTL0009936
35.29Single7DFPSpiperone7DFP-D2-Spiperone
35.29Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
35.29Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.29Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
35.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.29Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
35.29Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
35.29Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
35.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
35.29Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
35.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
35.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
35.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
34.78Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.78Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
34.78Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
33.33Single3NY8ICI 118-5513NY8-β2-ICI 118-551
33.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
33.33Single3OE6IT1t3OE6-CXCR4-IT1t
33.33Single3OE8IT1t3OE8-CXCR4-IT1t
33.33Single3UZAGTPL92363UZA-A2A-GTPL9236
33.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
33.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
33.33Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
33.33Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
33.33Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
33.33Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
33.33Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
33.33Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
33.33Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
33.33Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
33.33Single6GPSMK08126GPS-CCR2-MK0812
33.33Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
33.33Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
33.33Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6W25SHU91196W25-MC4-SHU9119-Ca
33.33Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7BU7BI1671077BU7-β1-BI167107
33.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
33.33Single7F83PF-051904577F83-Ghrelin-PF-05190457
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
33.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
33.33Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
33.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
33.33Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
33.33Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
33.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
33.33Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGJEpinephrine8GGJ-β2-Epinephrine
33.33Single8GGNEpinephrine8GGN-β2-Epinephrine
33.33Single8GGOEpinephrine8GGO-β2-Epinephrine
33.33Single8GGUEpinephrine8GGU-β2-Epinephrine
33.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
33.33Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
33.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
33.33Single8JJOAlprenolol8JJO-β2-Alprenolol
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusadenosine_onOrthosteric Liganda1_on a2_on
33.33Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
33.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
33.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
33.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
33.33Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
33.33Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
33.33Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Consensusgi_hcarOrthosteric Ligandgi_hca
33.33Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Consensushcar_offOrthosteric Ligandsuccinate_off
33.33Consensushistamine_onOrthosteric Ligandh1_on h4_on
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
33.33Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
33.33Consensusnucleotide_onOrthosteric Ligandadenosine_on
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
33.33Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
32.00Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
31.58Single4UG2CGS216804UG2-A2A-CGS21680
31.58Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
31.58Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.58Single7SK9CCX6627SK9-ACKR3-CCX662
31.58Single8X5YAstemizole8X5Y-H1-Astemizole
31.58Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
31.58Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
31.58Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
31.58Consensuslpl_offOrthosteric Ligands1p_off lpa_off
31.58Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
31.25Single2Y03Isoprenaline2Y03-β1-Isoprenaline
31.25Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
31.25Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
31.25Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
31.25Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
31.25Single5XPRBosentan5XPR-ETB-Bosentan
31.25Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
31.25Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Single6GPXMK08126GPX-CCR2-MK0812
31.25Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
31.25Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
31.25Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
31.25Single6PS6Timolol6PS6-β2-Timolol
31.25Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
31.25Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
31.25Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
31.25Single7WC6LSD7WC6-5-HT2A-LSD
31.25Single7XKAEpinephrine7XKA-β2-Epinephrine
31.25Single7YXAONO-54306087YXA-S1P5-ONO-5430608
31.25Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
31.25Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
31.25Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
31.25Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
31.25Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
31.25Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
31.25Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
31.25Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
31.25Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
31.25Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
31.25Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
31.25Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
31.25Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
31.25Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
31.25Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.25Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
31.25Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
31.25Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
31.25Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
31.25Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.77Single3OE9IT1t3OE9-CXCR4-IT1t
30.77Single3PBLEticlopride3PBL-D3-Eticlopride
30.77Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
30.77Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
30.77Single6HLLCP999946HLL-NK1-CP99994
30.77Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.77Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
30.77Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
30.77Single7SRQLSD7SRQ-5-HT2B-LSD
30.77Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
30.77Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
30.77Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
30.77Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
30.77Single8K5BNiacin8K5B-HCA2-Niacin
30.77Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
30.77Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
30.77Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
30.43Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
30.43Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.00Single7F8XNN90567F8X-CCKA-NN9056
30.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
30.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
30.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
30.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
30.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
30.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.00Consensussst_onOrthosteric Ligandsst2_on sst4_on
29.41Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
29.41Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
29.41Single4U15Tiotropium4U15-M3-Tiotropium
29.41Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
29.41Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
29.41Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
29.41Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
29.41Single5XRAAM115425XRA-CB1-AM11542
29.41Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
29.41Single6E59L-7607356E59-NK1-L-760735
29.41Single6J20Aprepitant6J20-NK1-Aprepitant
29.41Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.41Single6OL9Tiotropium6OL9-M5-Tiotropium
29.41Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
29.41Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.41Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
29.41Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
29.41Single7TUYGSK682753A7TUY-GPR183-GSK682753A
29.41Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
29.41Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
29.41Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.41Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
29.41Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
29.41Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
29.41Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
29.41Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
29.41Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
29.41Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
29.41Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
29.41Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
29.41Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
29.41Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
29.41Consensusa2_onOrthosteric Liganda2a_on a2b_on
29.41Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
29.41Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
29.41Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
29.41Consensuscck_onOrthosteric Ligandccka_on cckb_on
29.41Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
29.41Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
29.41Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
29.41Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
29.41Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
29.41Consensushistamine_offOrthosteric Ligandh1_off
29.41Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
29.41Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
29.41Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
29.41Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
29.41Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
29.41Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
29.17Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single3ODUIT1t3ODU-CXCR4-IT1t
28.57Single3QAKUK-4320973QAK-A2A-UK-432097
28.57Single5DHHSB-6121115DHH-NOP-SB-612111
28.57Single6AKYMaraviroc6AKY-CCR5-Maraviroc
28.57Single6HLOAprepitant6HLO-NK1-Aprepitant
28.57Single6KUXRS-799486KUX-α2a-RS-79948
28.57Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
28.57Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
28.57Single7BR3Elagolix7BR3-GnRH1-Elagolix
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
28.57Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
28.57Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
28.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
28.57Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
28.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
28.57Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
28.57Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
28.57Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
28.57Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
28.57Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
28.57Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8GGVEpinephrine8GGV-β2-Epinephrine
28.57Single8GGWEpinephrine8GGW-β2-Epinephrine
28.57Single8GGXEpinephrine8GGX-β2-Epinephrine
28.57Single8GH0Epinephrine8GH0-β2-Epinephrine
28.57Single8GNGIstradefylline8GNG-A2A-Istradefylline
28.57Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
28.57Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
28.57Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
28.57Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
28.57Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
28.57Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
28.57Consensusalpha1_onOrthosteric Ligandalpha1a_on
28.57Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
28.57Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
28.57Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
28.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
27.78Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
27.78Single4AMIBucindolol4AMI-β1-Bucindolol
27.78Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.78Single5CXVTiotropium5CXV-M1-Tiotropium
27.78Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
27.78Single5X33BIIL2605X33-BLT1-BIIL260
27.78Single6A93Risperidone6A93-5-HT2A-Risperidone
27.78Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
27.78Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
27.78Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
27.78Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
27.78Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.78Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
27.78Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.78Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
27.78Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
27.78Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
27.78Single8JJ8Formoterol8JJ8-β2-Formoterol
27.78Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
27.78Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.78Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
27.78Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
27.78Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
27.27Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
27.27Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
27.27Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
27.27Single5WF5UK-4320975WF5-A2A-UK-432097
27.27Single6PT2KGCHM076PT2-δ-KGCHM07
27.27Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
27.27Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
27.27Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single8PWNTheophylline8PWN-A2A-Theophylline
27.27Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
27.27Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
27.27Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
27.27Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
26.92Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
26.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.67Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
26.67Single6VI4JDTic6VI4-κ-JDTic
26.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
26.67Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.67Single7AROLUF58337ARO-A2A-LUF5833-Na
26.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.67Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
26.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
26.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
26.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
26.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
26.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
26.67Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
26.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.67Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
26.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.67Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8GGIEpinephrine8GGI-β2-Epinephrine
26.67Single8GGKEpinephrine8GGK-β2-Epinephrine
26.67Single8GGMEpinephrine8GGM-β2-Epinephrine
26.67Single8GGPEpinephrine8GGP-β2-Epinephrine
26.67Single8GGTEpinephrine8GGT-β2-Epinephrine
26.67Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
26.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
26.67Single8K2WAMG4878K2W-CXCR3-AMG487
26.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
26.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
26.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.67Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
26.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
26.67Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
26.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
26.67Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.67Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
26.67Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
26.67Consensuss1p_offOrthosteric Ligands1p1_off
26.32Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
26.32Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
26.32Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
26.32Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.32Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
26.32Single6H7LDobutamine6H7L-β1-Dobutamine
26.32Single6IBLArformoterol6IBL-β1-Arformoterol
26.32Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
26.32Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
26.32Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
26.32Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.32Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
26.32Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
26.32Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.32Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.32Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.32Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
26.32Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.32Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
26.32Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
26.32Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Single7C61Ergotamine7C61-5-HT1B-Ergotamine
26.09Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.09Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
26.09Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
26.09Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
26.09Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
25.93Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
25.00Single2Y01Dobutamine2Y01-β1-Dobutamine
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3NY9PubChem 9131033NY9-β2-PubChem 913103
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
25.00Single4DAJTiotropium4DAJ-M3-Tiotropium
25.00Single4MQSIperoxo4MQS-M2-Iperoxo
25.00Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
25.00Single4U14Tiotropium4U14-M3-Tiotropium
25.00Single5DSGTiotropium5DSG-M4-Tiotropium
25.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5WF6UK-4320975WF6-A2A-UK-432097
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
25.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
25.00Single6H7MSalbutamol6H7M-β1-Salbutamol
25.00Single6IIVDaltroban6IIV-TP-Daltroban
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
25.00Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6PT3DPI-2876PT3-δ-DPI-287
25.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
25.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
25.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
25.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
25.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
25.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
25.00Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
25.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
25.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
25.00Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
25.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
25.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
25.00Single8X63Mepyramine8X63-H1-Mepyramine
25.00Single8X64Desloratadine8X64-H1-Desloratadine
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
25.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
25.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensusleuko_onOrthosteric Ligandblt_on
25.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
25.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
25.00Consensussensory_onOrthosteric Ligandopsin_on
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
25.00Consensustar_onOrthosteric Ligandta1_on
25.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
24.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
24.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
23.81Single4IARErgotamine4IAR-5-HT1B-Ergotamine
23.81Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single7QA8Peptide7QA8-STE2-Peptide
23.81Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
23.81Consensusclass-d_offOrthosteric Ligandste2_off
23.81Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
23.81Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.81Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
23.53Single2Y00Dobutamine2Y00-β1-Dobutamine
23.53Single5CGCHTL142425CGC-mGlu5-HTL14242
23.53Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
23.53Single5N2SPSB365N2S-A1-PSB36
23.53Single5TVNLSD5TVN-5-HT2B-LSD
23.53Single5WIUNemonapride5WIU-D4-Nemonapride
23.53Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.53Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
23.53Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
23.53Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.53Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.53Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.53Single6E67BI1671076E67-β2-BI167107-Gs (fused)
23.53Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
23.53Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
23.53Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.53Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.53Single7C4SS1P7C4S-S1P3-S1P
23.53Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
23.53Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
23.53Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
23.53Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
23.53Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
23.53Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
23.53Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.53Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
23.53Single8EA0Iperoxo8EA0-M3-Iperoxo
23.53Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
23.53Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
23.53Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.53Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
23.53Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
23.53Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.53Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
23.53Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
23.53Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
23.53Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
23.53Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
23.53Consensusep_offOrthosteric Ligandep4_off
23.53Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
23.53Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.08Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.08Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.08Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
23.08Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
23.08Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
23.08Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
23.08Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.08Single8GGREpinephrine8GGR-β2-Epinephrine
23.08Single8GGZEpinephrine8GGZ-β2-Epinephrine
23.08Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.08Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
22.73Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
22.73Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
22.73Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
22.73Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
22.73Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
22.73Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
22.73Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
22.73Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
22.73Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
22.73Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
22.73Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.73Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
22.22Single3P0GBI1671073P0G-β2-BI167107
22.22Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.22Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
22.22Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
22.22Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
22.22Single6IGLIRL16206IGL-ETB-IRL1620
22.22Single6J21Aprepitant6J21-NK1-Aprepitant
22.22Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
22.22Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single6WGTLSD6WGT-5-HT2A-LSD
22.22Single7B6WCyclazosin7B6W-α1b-Cyclazosin
22.22Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
22.22Single7EPENAM5637EPE-mGlu-NAM563
22.22Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
22.22Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
22.22Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
22.22Single7P2L4YI7P2L-mGlu5-4YI
22.22Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
22.22Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.22Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
22.22Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.22Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
22.22Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
22.22Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
22.22Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
22.22Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
22.22Consensus5ht5_offOrthosteric Ligand5ht5a_off
22.22Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.22Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
22.22Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.22Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
22.22Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.22Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.22Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Consensuslpa_offOrthosteric Ligandlpa1_off
22.22Consensuslpa_onOrthosteric Ligandlpa1_on
22.22Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
22.22Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
22.22Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
22.22Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.74Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
21.74Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
21.74Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
21.74Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
21.74Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.74Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
21.43Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
21.43Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
21.43Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
21.43Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.43Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.43Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
21.43Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.43Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.43Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
21.43Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
21.43Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
21.43Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.43Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
21.43Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8GGSEpinephrine8GGS-β2-Epinephrine
21.43Single8GGYEpinephrine8GGY-β2-Epinephrine
21.43Single8GH1Epinephrine8GH1-β2-Epinephrine
21.43Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
21.43Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
21.43Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
21.43Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.43Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
21.43Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
21.43Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
21.43Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
21.43Consensusclass-t_onOrthosteric Ligandtaste2_on
21.43Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
21.43Consensusgo_class-b2Orthosteric Ligandgo_adhesion
21.43Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.43Consensusgs_class-tOrthosteric Ligandgs_taste
21.43Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.43Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
21.43Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
21.05Single4N4WSANT-14N4W-SMO-SANT-1
21.05Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
21.05Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.05Single6CM4Risperidone6CM4-D2-Risperidone
21.05Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
21.05Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
21.05Single6IIURamatroban6IIU-TP-Ramatroban
21.05Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
21.05Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
21.05Single6MXTSalmeterol6MXT-β2-Salmeterol
21.05Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.05Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.05Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
21.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.05Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
21.05Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
21.05Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.05Single8JJLOlodaterol8JJL-β2-Olodaterol
21.05Single8JWZAB9288JWZ-A2A-AB928-Na
21.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
21.05Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
21.05Single8WU1KCA8WU1-CB1-KCA-Arrestin1
21.05Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
21.05Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
21.05Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
21.05Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.05Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
21.05Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.05Consensusclass-b2_onOrthosteric Ligandadgrg_on
21.05Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.05Consensusgi_class-fOther Ligandgi_frizzled
21.05Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
21.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
21.05Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
21.05Consensusgs_steroidOrthosteric Ligandgs_bileacid
21.05Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.05Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
20.83Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.83Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.83Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.83Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.83Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
20.83Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.83Consensusclass-d_onOrthosteric Ligandste2_on
20.83Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.83Consensusgi_class-dOrthosteric Ligandgi_ste
20.83Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.83Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.83Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
20.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
20.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
20.00Single3PWHZM2413853PWH-A2A-ZM241385
20.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
20.00Single5CGDHTL142425CGD-mGlu5-HTL14242
20.00Single5K2DZM2413855K2D-A2A-ZM241385
20.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
20.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
20.00Single5U09Taranabant5U09-CB1-Taranabant
20.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
20.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
20.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.00Single6JZHZM2413856JZH-A2A-ZM241385-Na
20.00Single6K1QIRL25006K1Q-ETB-IRL2500
20.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
20.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Single6PS7ZM2413856PS7-A2A-ZM241385-Na
20.00Single7EZCUKA7EZC-A2A-UKA
20.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
20.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
20.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
20.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
20.00Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
20.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
20.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
20.00Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
20.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
20.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
20.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
20.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
20.00Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
20.00Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
20.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
20.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
20.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.00Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
20.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
20.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
20.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
20.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
20.00Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
20.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
20.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
20.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgt_class-aOrthosteric Ligandgt_opsin
20.00Consensusgt_opsinOrthosteric Ligandgt_sensory
20.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
20.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
20.00Consensussteroid_onOrthosteric Ligandbileacid_on
19.44Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
19.23Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
19.23Single7SK3CXCL127SK3-ACKR3-CXCL12
19.23Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
19.23Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
19.05Single5EE7MK08935EE7-Glucagon-MK0893
19.05Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
19.05Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
19.05Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
19.05Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
19.05Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
19.05Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
19.05Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
19.05Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
19.05Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusclass-d_offOrthosteric Ligandste2_off
19.05Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
19.05Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
19.05Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
18.75Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
18.75Single3REYPubChem 56973REY-A2A-PubChem 5697
18.75Single3RZECidoxepin3RZE-H1-Cidoxepin
18.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
18.75Single5IU4ZM2413855IU4-A2A-ZM241385-Na
18.75Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.75Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.75Single5JTBZM2413855JTB-A2A-ZM241385
18.75Single5K2BZM2413855K2B-A2A-ZM241385-Na
18.75Single5K2CZM2413855K2C-A2A-ZM241385-Na
18.75Single5NLXZM2413855NLX-A2A-ZM241385-Na
18.75Single5NM4ZM2413855NM4-A2A-ZM241385-Na
18.75Single6AQFZM2413856AQF-A2A-ZM241385
18.75Single6FFIMMPEP6FFI-mGlu5-MMPEP
18.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
18.75Single6MH8ZM2413856MH8-A2A-ZM241385
18.75Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
18.75Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
18.75Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
18.75Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.75Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
18.75Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
18.75Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
18.75Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
18.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
18.75Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
18.75Single8GGLEpinephrine8GGL-β2-Epinephrine
18.75Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
18.75Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
18.75Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
18.75Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.75Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
18.75Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
18.75Consensussensory_offOrthosteric Ligandopsin_off
18.52Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
18.52Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
18.52Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.18Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single4XT1Fractalkine4XT1-US28-Fractalkine
18.18Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
18.18Single6W25Ca6W25-MC4-SHU9119-Ca
18.18Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.18Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
18.18Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
18.18Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
18.18Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.18Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
18.18Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
18.18Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
18.18Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
18.18Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
18.18Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
17.86Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
17.65Single3EMLZM2413853EML-A2A-ZM241385
17.65Single4EIYZM2413854EIY-A2A-ZM241385-Na
17.65Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
17.65Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.65Single5K2AZM2413855K2A-A2A-ZM241385-Na
17.65Single5OLGZM2413855OLG-A2A-ZM241385-Na
17.65Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
17.65Single5VRAZM2413855VRA-A2A-ZM241385-Na
17.65Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
17.65Single6D27CAY104716D27-DP2-CAY10471
17.65Single6FFHFenobam6FFH-mGlu5-Fenobam
17.65Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
17.65Single6LPJZM2413856LPJ-A2A-ZM241385-Na
17.65Single6LPKZM2413856LPK-A2A-ZM241385-Na
17.65Single6S0LZM2413856S0L-A2A-ZM241385
17.65Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
17.65Single7PYRPSB-21157PYR-A2A-PSB-2115
17.65Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
17.65Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
17.65Single7WC7Lisuride7WC7-5-HT2A-Lisuride
17.65Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
17.65Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
17.65Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.65Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
17.65Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
17.65Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
17.65Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
17.65Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.65Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
17.65Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
17.65Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
17.65Consensusa2_offOrthosteric Liganda2a_off
17.65Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
17.65Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
17.65Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.65Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
17.65Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
17.65Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
17.39Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
17.39Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
17.39Single7SK5CXCL127SK5-ACKR3-CXCL12
17.39Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
17.39Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
17.39Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
17.24Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single3OE0CVX153OE0-CXCR4-CVX15
16.67Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
16.67Single5IUAQ274563485IUA-A2A-Q27456348-Na
16.67Single5NM2ZM2413855NM2-A2A-ZM241385-Na
16.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
16.67Single6LPLZM2413856LPL-A2A-ZM241385-Na
16.67Single6LUQHaloperidol6LUQ-D2-Haloperidol
16.67Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
16.67Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
16.67Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
16.67Single6S0QZM2413856S0Q-A2A-ZM241385
16.67Single6WQAZM2413856WQA-A2A-ZM241385-Na
16.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
16.67Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
16.67Single7RM5ZM2413857RM5-A2A-ZM241385-Na
16.67Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
16.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
16.67Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
16.67Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
16.67Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
16.67Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
16.67Single8FYNZM2413858FYN-A2A-ZM241385-Na
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
16.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
16.67Single8GNEKW-63568GNE-A2A-KW-6356-Na
16.67Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
16.67Consensusangiotensin_onOrthosteric Ligandat1_on
16.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.67Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
16.67Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
16.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
16.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
16.67Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
16.13Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
16.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
16.00Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
16.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
16.00Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.79Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
15.79Single5TZR-5TZR-FFA1 (GPR40)-MK8666
15.79Single5V54Methiothepin5V54-5-HT1B-Methiothepin
15.79Single5XR8AM8415XR8-CB1-AM841
15.79Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
15.79Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
15.79Single7PX4PSB-21137PX4-A2A-PSB-2113
15.79Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
15.79Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
15.79Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
15.79Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
15.79Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
15.79Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
15.79Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
15.79Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
15.79Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.79Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
15.79Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
15.79Consensus5ht1_offOrthosteric Ligand5ht1b_off
15.79Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
15.79Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
15.79Consensuschemerin_onOrthosteric Ligandcml1_on
15.79Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.79Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
15.79Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.62Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.62Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.62Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
15.62Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
15.38Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
15.38Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
15.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
15.38Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
15.38Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
15.38Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.15Consensuspth_onOrthosteric Ligandpth1_on pth2_on
15.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
15.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
15.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
15.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
15.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
15.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
15.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.00Consensuschemokine_offOrthosteric Ligandcxcr_off
15.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
15.00Consensuscxcr_offOrthosteric Ligandcxcr4_off
15.00Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
15.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
15.00Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
14.81Single4XT3Fractalkine4XT3-US28-Fractalkine
14.81Single6FJ3PTH6FJ3-PTH1-PTH
14.81Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
14.81Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
14.29Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
14.29Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
14.29Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
14.29Single6ME5Agomelatine6ME5-MT1-Agomelatine
14.29Single6ME9Ramelteon6ME9-MT2-Ramelteon
14.29Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
14.29Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
14.29Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
14.29Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
14.29Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
14.29Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
14.29Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
14.29Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
14.29Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
14.29Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
14.29Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
14.29Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
14.29Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
14.29Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
14.29Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
14.29Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
14.29Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
14.29Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
14.29Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
14.29Consensusgi_class-dOrthosteric Ligandgi_ste
14.29Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
14.29Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.29Consensusgo_class-b1Orthosteric Ligandgo_crf
14.29Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
14.29Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.79Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
13.79Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
13.79Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.79Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
13.79Single8IY6Endothelin-18IY6-ETB-Endothelin-1
13.79Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.79Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.79Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
13.79Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
13.79Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.64Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.64Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.64Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
13.64Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
13.64Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.64Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
13.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
13.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.33Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
13.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
13.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
13.04Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
13.04Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
13.04Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
13.04Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
13.04Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
13.04Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
13.04Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
13.04Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
12.90Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.90Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
12.50Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
12.50Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
12.50Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.50Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
12.50Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
12.50Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.50Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.50Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
12.50Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
12.50Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
12.50Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
12.50Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
12.50Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
12.50Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
12.50Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.50Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
12.12Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
12.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
12.00Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
12.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
11.76Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
11.76Single5UVIZM2413855UVI-A2A-ZM241385
11.76Single6A94Zotepine6A94-5-HT2A-Zotepine
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
11.76Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.76Single6ZINSR486926ZIN-NTS1-SR48692
11.76Single7T32ZM2413857T32-A2A-ZM241385
11.76Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
11.76Single7VODCariprazine7VOD-5-HT2A-Cariprazine
11.76Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
11.76Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.76Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.76Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
11.76Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
11.76Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
11.76Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
11.76Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
11.76Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
11.76Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.76Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
11.54Single6JODAngiotensin II6JOD-AT2-Angiotensin II
11.54Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
11.54Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
11.54Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.54Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
11.11Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
11.11Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
11.11Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
11.11Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
11.11Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.11Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
11.11Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
11.11Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
11.11Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.11Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
11.11Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.11Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
11.11Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.11Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
11.11Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.11Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
11.11Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.11Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.11Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
11.11Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
11.11Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
11.11Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
10.71Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.71Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.71Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.71Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
10.71Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.53Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.53Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.53Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
10.53Single6Z4SSR486926Z4S-NTS1-SR48692
10.53Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
10.53Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
10.53Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.53Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
10.53Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.53Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.53Single8QOTNanobody E8QOT-μ-Nanobody E
10.53Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.53Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.34Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
10.34Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
10.26Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
10.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
10.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
10.00Single5V56TC1145V56-SMO-TC114
10.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
10.00Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
10.00Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
10.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
10.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
10.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
10.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
10.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
10.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.00Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
10.00Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.68Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
9.68Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
9.68Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.52Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
9.52Single4XEENeurotensin4XEE-NTS1-Neurotensin
9.52Single4XESNeurotensin4XES-NTS1-Neurotensin
9.52Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
9.52Single6OS2TRV0266OS2-AT1-TRV026
9.52Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
9.52Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
9.52Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.52Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.52Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.52Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
9.52Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
9.52Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
9.52Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
9.52Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
9.52Consensusnts_offOrthosteric Ligandnts1_off
9.52Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
9.38Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
9.38Consensusglp_onOrthosteric Ligandglp1_on glp2_on
9.09Single4BUONeurotensin4BUO-NTS1-Neurotensin
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
9.09Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
9.09Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
9.09Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.82Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.70Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.70Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
8.57Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
8.00Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
8.00Consensussst_offOrthosteric Ligandsst2_off
7.89Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
7.89Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.69Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
7.69Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.69Single7XNACYN1548067XNA-SST2-CYN154806
7.69Consensusclass-c_onOther Ligandgabab_on mglu_on
7.69Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
7.41Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
7.41Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
7.41Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
7.41Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
7.14Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
7.14Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
7.14Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
7.14Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
7.14Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.90Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.90Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
6.90Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.90Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.90Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
6.67Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
6.67Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.67Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.67Consensusadgrg3_onOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
6.67Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.67Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.45Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
6.45Single6LMLGlucagon6LML-Glucagon-Glucagon
6.25Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
6.25Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
6.25Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
6.25Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
6.06Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
6.06Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.88Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.88Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.88Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.88Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
5.88Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
5.88Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.88Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.88Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
5.71Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
5.56Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.56Single7VV6C48/807VV6-MRGPRX2-C48/80
5.56Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.56Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.56Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.56Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.41Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.26Single5T04Neurotensin5T04-NTS1-Neurotensin
5.26Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
5.00Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
5.00Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
5.00Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
5.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
4.76Single5V57TC1145V57-SMO-TC114
4.76Single6OS1TRV0266OS1-AT1-TRV026
4.76Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.76Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
4.76Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Single4PY02MeSATP4PY0-P2Y12-2MeSATP
4.55Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.55Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.55Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.55Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.55Consensusnts_onOrthosteric Ligandnts1_on
4.35Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.35Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
4.35Consensuscyslt_offOrthosteric Ligandcyslt2_off
4.17Single6KNMJN241-96KNM-Apelin-JN241-9
4.17Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
4.17Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
4.17Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
4.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.33Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.23Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.12Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.86Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
2.78Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
2.70Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
2.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2

PDB Summary
PDB 6TPJ
Class A
SubFamily Peptide
Type Orexin
SubType OX2
Species Homo sapiens
Ligand Suvorexant
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.74
Date 2020-01-01
D.O.I. 10.1021/acs.jmedchem.9b01787
Net Summary
Imin 3.39
Number of Linked Nodes 289
Number of Links 319
Number of Hubs 41
Number of Links mediated by Hubs 155
Number of Communities 10
Number of Nodes involved in Communities 51
Number of Links involved in Communities 66
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 53458
Length Of Smallest Path 3
Average Path Length 13.017
Length of Longest Path 31
Minimum Path Strength 1.07
Average Path Strength 6.13448
Maximum Path Strength 20.865
Minimum Path Correlation 0.7
Average Path Correlation 0.940214
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.34783
Average % Of Corr. Nodes 57.9788
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.5903
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeYCM
PDB ResiduesR:R:?147
Environment DetailsOpen EMBL-EBI Page
CodeYCM
NameCysteine-S-acetamide
SynonymsCYSTEINE-S-ACETAMIDE
Identifier(2R)-2-amino-3-(2-amino-2-oxo-ethyl)sulfanyl-propanoic acid
FormulaC5 H10 N2 O3 S
Molecular Weight178.209
SMILESC([C@@H](C(=O)O)N)SCC(=O)N
PubChem36688842
Formal Charge0
Total Atoms21
Total Chiral Atoms1
Total Bonds20
Total Aromatic Bonds0

CodeSUV
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeSUV
NameSuvorexant
Synonymssuvorexant
Identifier[(7R)-4-(5-chloranyl-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl]-[5-methyl-2-(1,2,3-triazol-2-yl)phenyl]methanone
FormulaC23 H23 Cl N6 O2
Molecular Weight450.921
SMILESCc1ccc(c(c1)C(=O)N2CCN(CC[C@H]2C)c3nc4cc(ccc4o3)Cl)n5nccn5
PubChem24965990
Formal Charge0
Total Atoms55
Total Chiral Atoms1
Total Bonds59
Total Aromatic Bonds21

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO43614
Sequence
>6TPJ_Chain_R
YLHPKEYAW VLIAGYIIV FVVALIGNV LVCVAVWKN HHMRTVTNL 
FIVNLSLAA VLVTITCLP ATLVVDITE TWFFGQSLC KVIPYLQTV 
SVSVSALTL S?IALDRWY AICHPLMFK STAKRALNS IVIIWIVSC 
IIMIPQAIV MECSTVFPG LADKTTAFT VCDERWGGE IAPKMYHIC 
FFLVTYAAP LCLMVLLYL QIFRKLWCR QKQIRARRK TARMLMVVV 
LVFAICYAP ISILNVLKR VFGMFAHTE DRETVYAWF AFSHWLVYA 
NSAANPIIY NFLSGKFRE EFKAAFSWW WLGVHH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4S0VAPeptideOrexinOX2Homo sapiensSuvorexant--2.52015-01-1410.1038/nature14035
5WQCAPeptideOrexinOX2Homo sapiensEMPA--1.962017-11-2910.1016/j.str.2017.11.005
5WS3APeptideOrexinOX2Homo sapiensEMPA--2.32017-12-1310.1016/j.str.2017.11.005
6TPGAPeptideOrexinOX2Homo sapiensEMPA--2.742020-01-0110.1021/acs.jmedchem.9b01787
6TPNAPeptideOrexinOX2Homo sapiensHTL6641--2.612020-01-0110.1021/acs.jmedchem.9b01787
7L1UAPeptideOrexinOX2Homo sapiensOrexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22021-02-1010.1038/s41467-021-21087-6
7L1VAPeptideOrexinOX2Homo sapiensPubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;232021-02-1010.1038/s41467-021-21087-6
7SQOAPeptideOrexinOX2Homo sapiensTAK-925-Gi1/&β;1/&γ;23.172022-05-2510.1038/s41467-022-30601-3
7SR8APeptideOrexinOX2Homo sapiensTAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;23.32022-06-0810.1038/s41467-022-30601-3
7XRRAPeptideOrexinOX2Homo sapiensLemborexant--2.892022-11-2310.1016/j.str.2022.11.001




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