psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E340	R:R:P50	9.43	No	No	0	1	5
2	R:R:K51	R:R:Y53	7.17	No	No	0	4	4
3	R:R:E52	R:R:W55	3.27	No	No	0	3	4
4	R:R:V56	R:R:Y53	3.79	No	No	0	6	4
5	R:R:V56	R:R:W55	7.36	No	No	0	6	4
6	R:R:L112	R:R:Y61	14.07	No	Yes	0	6	7
7	R:R:T347	R:R:Y61	4.99	No	Yes	0	4	7
8	R:R:W351	R:R:Y61	11.58	Yes	Yes	0	5	7
9	R:R:Y354	R:R:Y61	4.96	Yes	Yes	0	7	7
10	R:R:V64	R:R:W351	3.68	No	Yes	0	7	5
11	R:R:F65	R:R:L108	6.09	No	No	0	6	7
12	R:R:I70	R:R:V66	3.07	No	No	0	4	4
13	R:R:L69	R:R:V73	2.98	No	No	0	6	4
14	R:R:G71	R:R:I70	3.53	No	No	0	8	4
15	R:R:I70	R:R:L74	2.85	No	No	0	4	6
16	R:R:D100	R:R:N72	5.39	Yes	Yes	0	9	9
17	R:R:N72	R:R:V101	5.91	Yes	No	0	9	7
18	R:R:N72	R:R:P361	6.52	Yes	No	0	9	9
19	R:R:F375	R:R:L74	6.09	No	No	0	7	6
20	R:R:S97	R:R:V75	3.23	No	No	0	9	9
21	R:R:N365	R:R:V75	4.43	Yes	No	0	7	9
22	R:R:C76	R:R:S97	3.44	No	No	0	6	9
23	R:R:F379	R:R:V77	3.93	No	No	0	5	5
24	R:R:A78	R:R:F375	4.16	No	No	0	8	7
25	R:R:M85	R:R:V79	3.04	Yes	No	0	8	7
26	R:R:V79	R:R:V94	4.81	No	No	0	7	6
27	R:R:K81	R:R:W80	17.4	No	No	0	6	3
28	R:R:H84	R:R:N82	3.83	No	Yes	0	5	6
29	R:R:M85	R:R:N82	8.41	Yes	Yes	0	8	6
30	R:R:E374	R:R:N82	11.83	No	Yes	0	7	6
31	R:R:A378	R:R:N82	4.69	No	Yes	0	6	6
32	R:R:H83	R:R:R86	9.03	No	No	0	7	8
33	R:R:M85	R:R:N90	5.61	Yes	No	0	8	9
34	R:R:F371	R:R:M85	4.98	No	Yes	0	8	8
35	R:R:T87	R:R:T89	6.28	No	No	0	7	8
36	R:R:N90	R:R:T87	4.39	No	No	0	9	7
37	R:R:R170	R:R:Y91	4.12	No	No	0	4	4
38	R:R:C147	R:R:F92	5.59	No	Yes	0	6	8
39	R:R:F92	R:R:I148	5.02	Yes	No	0	8	8
40	R:R:F92	R:R:I173	5.02	Yes	No	0	8	8
41	R:R:I93	R:R:N365	7.08	No	Yes	0	8	7
42	R:R:L98	R:R:V94	2.98	No	No	0	5	6
43	R:R:N95	R:R:T144	7.31	No	No	0	9	7
44	R:R:I173	R:R:N95	8.5	No	No	0	8	9
45	R:R:N95	R:R:W177	6.78	No	No	0	9	9
46	R:R:D100	R:R:L96	5.43	Yes	Yes	1	9	9
47	R:R:L96	R:R:S141	3	Yes	No	1	9	9
48	R:R:L145	R:R:L96	4.15	Yes	Yes	1	9	9
49	R:R:L96	R:R:Y364	3.52	Yes	Yes	1	9	9
50	R:R:D100	R:R:S141	2.94	Yes	No	1	9	9
51	R:R:D100	R:R:S357	10.31	Yes	No	0	9	9
52	R:R:I105	R:R:V101	3.07	No	No	0	4	7
53	R:R:L102	R:R:S137	9.01	No	No	0	6	5
54	R:R:C107	R:R:V103	3.42	No	No	0	7	7
55	R:R:S137	R:R:V103	4.85	No	No	0	5	7
56	R:R:S357	R:R:V103	3.23	No	No	0	9	7
57	R:R:Q134	R:R:T106	2.83	Yes	No	0	7	5
58	R:R:C107	R:R:Q134	7.63	No	Yes	0	7	7
59	R:R:C107	R:R:Y354	6.72	No	Yes	0	7	7
60	R:R:L108	R:R:P109	3.28	No	No	0	7	8
61	R:R:L108	R:R:Y354	10.55	No	Yes	0	7	7
62	R:R:T111	R:R:V114	3.17	Yes	No	2	7	5
63	R:R:D115	R:R:T111	2.89	Yes	Yes	2	5	7
64	R:R:Q134	R:R:T111	4.25	Yes	Yes	2	7	7
65	R:R:H350	R:R:T111	8.21	Yes	Yes	2	5	7
66	R:R:T111	R:R:Y354	9.99	Yes	Yes	0	7	7
67	L:L:?1	R:R:T111	3.45	Yes	Yes	2	0	7
68	R:R:I116	R:R:L112	2.85	No	No	0	5	6
69	R:R:D115	R:R:V114	2.92	Yes	No	2	5	5
70	R:R:D115	R:R:T347	13.01	Yes	No	0	5	4
71	R:R:D115	R:R:H350	10.08	Yes	Yes	2	5	5
72	R:R:I116	R:R:T117	3.04	No	No	0	5	5
73	R:R:T117	R:R:T119	4.71	No	No	0	5	5
74	R:R:E118	R:R:F207	4.66	Yes	No	0	4	3
75	R:R:E118	R:R:R339	3.49	Yes	No	4	4	1
76	R:R:E118	R:R:Y343	14.59	Yes	No	4	4	3
77	R:R:F121	R:R:T119	6.49	No	No	0	4	5
78	R:R:F122	R:R:W120	11.02	No	Yes	0	6	7
79	R:R:C127	R:R:W120	7.84	No	Yes	2	9	7
80	R:R:C210	R:R:W120	13.06	No	Yes	2	9	7
81	L:L:?1	R:R:W120	7.99	Yes	Yes	2	0	7
82	R:R:F122	R:R:L126	10.96	No	No	0	6	5
83	R:R:C193	R:R:Q124	4.58	No	No	0	4	4
84	R:R:L126	R:R:S125	3	No	No	0	5	3
85	R:R:C127	R:R:C210	5.46	No	No	2	9	9
86	R:R:I189	R:R:K128	2.91	No	No	0	5	6
87	R:R:L133	R:R:V129	2.98	No	No	0	5	4
88	R:R:I130	R:R:P131	3.39	No	No	0	5	5
89	R:R:I130	R:R:Q134	4.12	No	Yes	0	5	7
90	L:L:?1	R:R:P131	8.96	Yes	No	0	0	5
91	R:R:M184	R:R:Y132	3.59	No	Yes	0	7	6
92	R:R:A188	R:R:Y132	5.34	No	Yes	0	6	6
93	L:L:?1	R:R:Q134	25.93	Yes	Yes	2	0	7
94	R:R:M184	R:R:T135	10.54	No	No	0	7	6
95	R:R:Q187	R:R:T135	2.83	No	No	0	6	6
96	L:L:?1	R:R:T135	5.74	Yes	No	0	0	6
97	R:R:S139	R:R:V136	3.23	No	No	5	7	5
98	R:R:S180	R:R:V136	3.23	No	No	5	8	5
99	R:R:M184	R:R:V136	4.56	No	No	0	7	5
100	L:L:?1	R:R:V138	16.25	Yes	No	0	0	6
101	R:R:S139	R:R:S180	4.89	No	No	5	7	8
102	R:R:I176	R:R:V140	3.07	No	No	0	6	7
103	R:R:V140	R:R:W177	13.48	No	No	0	7	9
104	R:R:P235	R:R:V142	3.53	No	No	0	9	8
105	R:R:L143	R:R:S146	3	No	No	0	6	7
106	R:R:I176	R:R:L143	9.99	No	No	0	6	6
107	R:R:I148	R:R:T144	3.04	No	No	0	8	7
108	R:R:L145	R:R:M239	2.83	Yes	Yes	1	9	8
109	R:R:F313	R:R:L145	3.65	Yes	Yes	1	9	9
110	R:R:L145	R:R:Y364	7.03	Yes	Yes	1	9	9
111	R:R:L238	R:R:S146	3	No	No	0	7	7
112	R:R:C147	R:R:S172	3.44	No	No	0	6	6
113	R:R:I148	R:R:R152	5.01	No	No	0	8	9
114	R:R:A149	R:R:M239	3.22	No	Yes	1	8	8
115	R:R:A149	R:R:Y243	4	No	Yes	1	8	9
116	R:R:L150	R:R:W153	3.42	No	Yes	3	6	8
117	R:R:L150	R:R:Y154	4.69	No	No	3	6	4
118	R:R:D151	R:R:S164	5.89	No	No	0	9	5
119	R:R:L306	R:R:R152	3.64	No	No	0	8	9
120	R:R:R152	R:R:Y364	5.14	No	Yes	0	9	9
121	R:R:W153	R:R:Y154	17.36	Yes	No	3	8	4
122	R:R:C157	R:R:W153	7.84	No	Yes	3	7	8
123	R:R:H158	R:R:W153	5.29	Yes	Yes	3	6	8
124	R:R:Q245	R:R:W153	5.48	No	Yes	3	5	8
125	R:R:K163	R:R:Y154	13.14	No	No	0	5	4
126	R:R:I156	R:R:I246	10.3	No	No	0	8	9
127	R:R:C157	R:R:H158	4.42	No	Yes	3	7	6
128	R:R:C157	R:R:Q245	3.05	No	No	3	7	5
129	R:R:H158	R:R:M161	6.57	Yes	No	0	6	5
130	R:R:K163	R:R:M161	2.88	No	No	0	5	5
131	R:R:K163	R:R:R168	4.95	No	No	0	5	7
132	R:R:K167	R:R:N171	5.6	No	No	0	5	3
133	R:R:I182	R:R:I183	2.94	No	No	0	3	5
134	R:R:I185	R:R:P186	3.39	No	No	0	5	6
135	R:R:P186	R:R:Y223	15.3	No	Yes	0	6	8
136	R:R:Q187	R:R:Y223	12.4	No	Yes	0	6	8
137	R:R:I189	R:R:V190	3.07	No	No	0	5	6
138	R:R:V190	R:R:W214	19.61	No	Yes	0	6	4
139	R:R:E212	R:R:M191	8.12	Yes	No	0	4	6
140	R:R:E192	R:R:R213	15.12	No	No	0	5	4
141	R:R:T195	R:R:T208	4.71	No	No	0	2	3
142	R:R:F207	R:R:L206	7.31	No	No	0	3	4
143	R:R:D211	R:R:E212	5.2	No	Yes	0	5	4
144	R:R:E212	R:R:W214	5.45	Yes	Yes	0	4	4
145	R:R:E212	R:R:R328	9.3	Yes	Yes	0	4	4
146	R:R:P220	R:R:W214	21.62	No	Yes	0	5	4
147	R:R:W214	R:R:Y223	4.82	Yes	Yes	0	4	8
148	R:R:I218	R:R:Y219	3.63	No	No	0	4	3
149	R:R:K221	R:R:V329	4.55	No	No	0	4	5
150	R:R:H224	R:R:Y223	4.36	No	Yes	0	6	8
151	R:R:H224	R:R:R328	20.31	No	Yes	0	6	4
152	R:R:F227	R:R:T231	14.27	No	No	0	5	6
153	L:L:?1	R:R:F227	4.75	Yes	No	0	0	5
154	R:R:F228	R:R:S321	3.96	No	No	0	6	6
155	R:R:F228	R:R:V325	5.24	No	No	0	6	6
156	R:R:L236	R:R:Y232	4.69	No	Yes	0	6	8
157	R:R:Y232	R:R:Y317	3.97	Yes	Yes	0	8	7
158	R:R:L318	R:R:Y232	3.52	No	Yes	0	6	8
159	R:R:S321	R:R:Y232	7.63	No	Yes	0	6	8
160	R:R:C237	R:R:M233	3.24	No	No	0	4	5
161	R:R:M239	R:R:Y243	3.59	Yes	Yes	1	8	9
162	R:R:L310	R:R:M239	2.83	No	Yes	1	8	8
163	R:R:F313	R:R:M239	8.71	Yes	Yes	1	9	8
164	R:R:L310	R:R:V240	4.47	No	No	0	8	5
165	R:R:L306	R:R:Y243	7.03	No	Yes	0	8	9
166	R:R:L310	R:R:Y243	7.03	No	Yes	1	8	9
167	R:R:I246	R:R:L250	2.85	No	Yes	0	9	8
168	R:R:I246	R:R:L306	4.28	No	No	0	9	8
169	R:R:F247	R:R:W251	12.03	No	No	0	6	5
170	R:R:F247	R:R:M307	3.73	No	No	0	6	6
171	R:R:K249	R:R:L250	2.82	No	Yes	0	5	8
172	R:R:L250	R:R:R299	6.07	Yes	No	0	8	8
173	R:R:A303	R:R:L250	3.15	No	Yes	0	7	8
174	R:R:R300	R:R:W251	32.99	No	No	0	5	5
175	R:R:I293	R:R:R297	3.76	No	No	0	2	5
176	R:R:K294	R:R:R297	8.66	No	No	0	3	5
177	R:R:Q295	R:R:R299	5.84	No	No	0	4	8
178	R:R:I296	R:R:R300	6.26	No	No	0	4	5
179	R:R:M305	R:R:V308	3.04	No	No	0	8	6
180	R:R:I363	R:R:M305	2.92	No	No	0	8	8
181	R:R:L367	R:R:M305	7.07	No	No	0	7	8
182	R:R:I363	R:R:V309	6.14	No	No	1	8	8
183	R:R:V309	R:R:Y364	5.05	No	Yes	1	8	9
184	R:R:F313	R:R:Y317	7.22	Yes	Yes	1	9	7
185	R:R:F313	R:R:N356	3.62	Yes	Yes	1	9	9
186	R:R:C316	R:R:N356	7.87	No	Yes	0	8	9
187	R:R:V353	R:R:Y317	8.83	No	Yes	0	7	7
188	R:R:N356	R:R:Y317	8.14	Yes	Yes	1	9	7
189	R:R:L318	R:R:P319	6.57	No	No	0	6	9
190	R:R:I322	R:R:L318	2.85	No	No	0	5	6
191	R:R:P319	R:R:S349	3.56	No	No	0	9	6
192	R:R:L352	R:R:P319	3.28	No	No	0	8	9
193	R:R:I320	R:R:S349	4.64	Yes	No	0	7	6
194	R:R:H350	R:R:I320	5.3	Yes	Yes	2	5	7
195	R:R:I320	R:R:V353	3.07	Yes	No	0	7	7
196	L:L:?1	R:R:I320	7.78	Yes	Yes	2	0	7
197	R:R:I322	R:R:L326	2.85	No	No	0	5	5
198	R:R:N324	R:R:R328	3.62	No	Yes	0	7	4
199	L:L:?1	R:R:N324	7.49	Yes	No	0	0	7
200	R:R:F330	R:R:L326	3.65	No	No	0	3	5
201	R:R:L326	R:R:M332	2.83	No	No	0	5	3
202	R:R:K327	R:R:R328	7.43	No	Yes	0	3	4
203	R:R:F346	R:R:K327	7.44	No	No	0	4	3
204	R:R:F330	R:R:V329	3.93	No	No	0	3	5
205	R:R:F333	R:R:V342	6.55	No	No	0	4	5
206	R:R:F333	R:R:W345	4.01	No	No	0	4	5
207	R:R:D338	R:R:T341	2.89	No	No	0	3	4
208	R:R:R339	R:R:Y343	6.17	No	No	4	1	3
209	R:R:F346	R:R:H350	3.39	No	Yes	0	4	5
210	R:R:F348	R:R:L352	10.96	No	No	0	4	8
211	L:L:?1	R:R:H350	8.01	Yes	Yes	2	0	5
212	R:R:L352	R:R:W351	3.42	No	Yes	0	8	5
213	R:R:A355	R:R:W351	5.19	No	Yes	0	4	5
214	R:R:N356	R:R:N360	9.54	Yes	No	0	9	9
215	R:R:N360	R:R:Y364	12.79	No	Yes	0	9	9
216	R:R:F366	R:R:I362	7.54	No	No	0	5	6
217	R:R:I363	R:R:Y364	3.63	No	Yes	1	8	9
218	R:R:F371	R:R:N365	26.58	No	Yes	0	8	7
219	R:R:F371	R:R:S368	3.96	No	No	0	8	8
220	R:R:G369	R:R:R372	4.5	No	No	0	5	8
221	R:R:F375	R:R:F379	10.72	No	No	0	7	5
222	R:R:K376	R:R:S380	7.65	No	No	0	5	4
223	R:R:A169	R:R:F92	2.77	No	Yes	0	7	8
224	R:R:A303	R:R:F247	2.77	No	No	0	7	6
225	R:R:E54	R:R:I58	2.73	No	No	0	7	5
226	R:R:E217	R:R:K221	2.7	No	No	0	3	4
227	R:R:C181	R:R:Y132	2.69	No	Yes	0	4	6
228	R:R:F121	R:R:V113	2.62	No	No	0	4	4
229	R:R:F346	R:R:V342	2.62	No	No	0	4	5
230	R:R:A242	R:R:W153	2.59	No	Yes	0	5	8
231	R:R:E373	R:R:E374	2.54	No	No	0	5	7
232	R:R:V342	R:R:Y343	2.52	No	No	0	5	3
233	R:R:F65	R:R:I62	2.51	No	No	0	6	3
234	R:R:F228	R:R:M233	2.49	No	No	0	6	5
235	R:R:E337	R:R:H335	2.46	No	No	0	2	1
236	R:R:F65	R:R:L69	2.44	No	No	0	6	6
237	R:R:D151	R:R:F92	2.39	No	Yes	0	9	8
238	R:R:L57	R:R:Y53	2.34	No	No	0	5	4
239	R:R:L323	R:R:W345	2.28	No	No	0	5	5
240	R:R:G215	R:R:G216	2.11	No	No	0	4	5
241	R:R:A59	R:R:G60	1.95	No	No	0	4	4
242	R:R:A234	R:R:P235	1.87	No	No	0	5	9
243	R:R:C127	R:R:C193	1.82	No	No	2	9	4
244	R:R:C193	R:R:C210	1.82	No	No	2	4	9
245	R:R:A358	R:R:A68	1.79	No	No	0	5	8
246	R:R:A149	R:R:A242	1.79	No	No	0	8	5
247	R:R:P235	R:R:S146	1.78	No	No	0	9	7
248	R:R:G60	R:R:I63	1.76	No	No	0	4	3
249	R:R:A99	R:R:S137	1.71	No	No	0	8	5
250	R:R:A99	R:R:S141	1.71	No	No	0	8	9
251	R:R:G123	R:R:L126	1.71	No	No	0	8	5
252	R:R:C316	R:R:V312	1.71	No	No	0	8	6
253	R:R:A358	R:R:V64	1.7	No	No	0	5	7
254	R:R:A358	R:R:V67	1.7	No	No	0	5	5
255	R:R:G71	R:R:N72	1.7	No	Yes	0	8	9
256	R:R:A166	R:R:V88	1.7	No	No	0	3	6
257	R:R:A169	R:R:V88	1.7	No	No	0	7	6
258	R:R:A68	R:R:T104	1.68	No	No	0	8	7
259	R:R:L160	R:R:P159	1.64	No	No	0	7	9
260	R:R:S194	R:R:V196	1.62	No	No	0	3	3
261	R:R:A78	R:R:M85	1.61	No	Yes	0	8	8
262	R:R:C226	R:R:L229	1.59	No	No	0	4	4
263	R:R:T231	R:R:V230	1.59	No	No	0	6	4
264	R:R:A314	R:R:L236	1.58	No	No	0	5	6
265	R:R:I175	R:R:V174	1.54	No	No	0	3	3
266	R:R:I183	R:R:V179	1.54	No	No	0	5	5
267	R:R:I225	R:R:V329	1.54	No	No	0	5	5
268	R:R:H158	R:R:P159	1.53	Yes	No	0	6	9
269	R:R:K81	R:R:V77	1.52	No	No	0	6	5
270	R:R:A110	R:R:Q134	1.52	No	Yes	0	4	7
271	R:R:L229	R:R:V230	1.49	No	No	0	4	4
272	R:R:L57	R:R:T347	1.47	No	No	0	5	4
273	R:R:I182	R:R:I185	1.47	No	No	0	3	5
274	R:R:E118	R:R:V209	1.43	Yes	No	0	4	5
275	R:R:G60	R:R:W351	1.41	No	Yes	0	4	5
276	R:R:G215	R:R:W214	1.41	No	Yes	0	4	4
277	R:R:P220	R:R:Y219	1.39	No	No	0	5	3
278	R:R:E373	R:R:K370	1.35	No	No	0	5	7
279	R:R:A166	R:R:Y91	1.33	No	No	0	3	4
280	R:R:L241	R:R:Q245	1.33	No	No	0	4	5
281	R:R:F207	R:R:V196	1.31	No	No	0	3	3
282	R:R:D338	R:R:E337	1.3	No	No	0	3	2
283	R:R:R339	R:R:T336	1.29	No	No	0	1	4
284	R:R:K301	R:R:R304	1.24	No	No	0	8	8
285	R:R:N171	R:R:R170	1.21	No	No	0	3	4
286	R:R:F366	R:R:N365	1.21	No	Yes	0	5	7
287	R:R:M222	R:R:Y223	1.2	No	Yes	0	4	8
288	R:R:H83	R:R:H84	1.19	No	No	0	7	5
289	R:R:L133	R:R:Y132	1.17	No	Yes	0	5	6
290	R:R:E54	R:R:W55	1.09	No	No	0	7	4
291	R:R:R300	R:R:R304	1.07	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y61	8.9	4	0	7
2	R:R:N72	4.88	4	0	9
3	R:R:N82	7.19	4	0	6
4	R:R:M85	4.73	5	0	8
5	R:R:F92	4.158	5	0	8
6	R:R:L96	4.025	4	1	9
7	R:R:D100	6.0175	4	1	9
8	R:R:T111	5.32667	6	2	7
9	R:R:D115	7.225	4	2	5
10	R:R:E118	6.0425	4	4	4
11	R:R:W120	9.9775	4	2	7
12	R:R:Y132	3.1975	4	0	6
13	R:R:Q134	7.71333	6	2	7
14	R:R:L145	4.415	4	1	9
15	R:R:W153	6.99667	6	3	8
16	R:R:H158	4.4525	4	3	6
17	R:R:E212	7.0175	4	0	4
18	R:R:W214	10.582	5	0	4
19	R:R:Y223	7.616	5	0	8
20	R:R:Y232	4.9525	4	0	8
21	R:R:M239	4.236	5	1	8
22	R:R:Y243	5.4125	4	1	9
23	R:R:L250	3.7225	4	0	8
24	R:R:F313	5.8	4	1	9
25	R:R:Y317	7.04	4	1	7
26	R:R:I320	5.1975	4	2	7
27	R:R:R328	10.165	4	0	4
28	R:R:H350	6.998	5	2	5
29	R:R:W351	5.056	5	0	5
30	R:R:Y354	8.055	4	0	7
31	R:R:N356	7.2925	4	1	9
32	R:R:Y364	6.19333	6	1	9
33	R:R:N365	9.825	4	0	7
34	L:L:?1	9.635	10	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V56	R:R:W55	13.497	7.36	No	No	0	6	4
2	R:R:V56	R:R:Y53	16.8314	3.79	No	No	0	6	4
3	R:R:L57	R:R:Y53	23.4501	2.34	No	No	0	5	4
4	R:R:L57	R:R:T347	26.4494	1.47	No	No	0	5	4
5	R:R:T347	R:R:Y61	13.3294	4.99	No	Yes	0	4	7
6	R:R:L112	R:R:Y61	18.5573	14.07	No	Yes	0	6	7
7	R:R:W351	R:R:Y61	24.07	11.58	Yes	Yes	0	5	7
8	R:R:Y354	R:R:Y61	38.8489	4.96	Yes	Yes	0	7	7
9	R:R:V64	R:R:W351	14.2342	3.68	No	Yes	0	7	5
10	R:R:F65	R:R:L108	10.7825	6.09	No	No	0	6	7
11	R:R:L108	R:R:Y354	16.0774	10.55	No	Yes	0	7	7
12	R:R:G71	R:R:I70	74.2041	3.53	No	No	0	8	4
13	R:R:G71	R:R:N72	76.1813	1.7	No	Yes	0	8	9
14	R:R:D100	R:R:N72	83.9226	5.39	Yes	Yes	0	9	9
15	R:R:D100	R:R:S357	72.7631	10.31	Yes	No	0	9	9
16	R:R:S357	R:R:V103	73.0228	3.23	No	No	0	9	7
17	R:R:C107	R:R:V103	78.5607	3.42	No	No	0	7	7
18	R:R:C107	R:R:Y354	36.126	6.72	No	Yes	0	7	7
19	R:R:I70	R:R:L74	70.1994	2.85	No	No	0	4	6
20	R:R:F375	R:R:L74	68.1635	6.09	No	No	0	7	6
21	R:R:A78	R:R:F375	58.0345	4.16	No	No	0	8	7
22	R:R:A78	R:R:M85	55.9065	1.61	No	Yes	0	8	8
23	R:R:F371	R:R:M85	21.9588	4.98	No	Yes	0	8	8
24	R:R:F371	R:R:N365	17.1498	26.58	No	Yes	0	8	7
25	R:R:F375	R:R:F379	10.0034	10.72	No	No	0	7	5
26	R:R:M85	R:R:N82	19.7637	8.41	Yes	Yes	0	8	6
27	R:R:D100	R:R:L96	50.1592	5.43	Yes	Yes	1	9	9
28	R:R:L96	R:R:Y364	33.2607	3.52	Yes	Yes	1	9	9
29	R:R:R152	R:R:Y364	85.9752	5.14	No	Yes	0	9	9
30	R:R:I148	R:R:R152	80.8646	5.01	No	No	0	8	9
31	R:R:F92	R:R:I148	42.3509	5.02	Yes	No	0	8	8
32	R:R:A169	R:R:F92	23.7433	2.77	No	Yes	0	7	8
33	R:R:A169	R:R:V88	20.4005	1.7	No	No	0	7	6
34	R:R:A166	R:R:V88	17.0409	1.7	No	No	0	3	6
35	R:R:A166	R:R:Y91	13.6645	1.33	No	No	0	3	4
36	R:R:R170	R:R:Y91	10.2714	4.12	No	No	0	4	4
37	R:R:D115	R:R:T347	24.3633	13.01	Yes	No	0	5	4
38	R:R:D115	R:R:H350	21.875	10.08	Yes	Yes	2	5	5
39	R:R:H350	R:R:I320	34.6431	5.3	Yes	Yes	2	5	7
40	R:R:I320	R:R:V353	99.8995	3.07	Yes	No	0	7	7
41	R:R:V353	R:R:Y317	100	8.83	No	Yes	0	7	7
42	R:R:F313	R:R:Y317	87.1062	7.22	Yes	Yes	1	9	7
43	R:R:F313	R:R:L145	45.4005	3.65	Yes	Yes	1	9	9
44	R:R:L145	R:R:Y364	35.2296	7.03	Yes	Yes	1	9	9
45	R:R:N356	R:R:Y317	39.1924	8.14	Yes	Yes	1	9	7
46	R:R:N356	R:R:N360	37.3408	9.54	Yes	No	0	9	9
47	R:R:N360	R:R:Y364	36.7795	12.79	No	Yes	0	9	9
48	R:R:I148	R:R:T144	35.8495	3.04	No	No	0	8	7
49	R:R:N95	R:R:T144	32.5905	7.31	No	No	0	9	7
50	R:R:N95	R:R:W177	30.3787	6.78	No	No	0	9	9
51	L:L:?1	R:R:T111	23.9444	3.45	Yes	Yes	2	0	7
52	L:L:?1	R:R:H350	16.0439	8.01	Yes	Yes	2	0	5
53	R:R:I116	R:R:L112	15.5328	2.85	No	No	0	5	6
54	R:R:I116	R:R:T117	12.4581	3.04	No	No	0	5	5
55	R:R:E118	R:R:Y343	19.3616	14.59	Yes	No	4	4	3
56	R:R:V342	R:R:Y343	29.1974	2.52	No	No	0	5	3
57	R:R:F346	R:R:V342	41.5717	2.62	No	No	0	4	5
58	R:R:F346	R:R:H350	46.1629	3.39	No	Yes	0	4	5
59	R:R:E118	R:R:F207	13.1535	4.66	Yes	No	0	4	3
60	R:R:F122	R:R:W120	10.0788	11.02	No	Yes	0	6	7
61	L:L:?1	R:R:W120	26.8432	7.99	Yes	Yes	2	0	7
62	R:R:V190	R:R:W214	13.8153	19.61	No	Yes	0	6	4
63	R:R:E212	R:R:W214	21.4058	5.45	Yes	Yes	0	4	4
64	R:R:E212	R:R:R328	27.6977	9.3	Yes	Yes	0	4	4
65	R:R:N324	R:R:R328	30.1022	3.62	No	Yes	0	7	4
66	L:L:?1	R:R:N324	31.9538	7.49	Yes	No	0	0	7
67	R:R:W214	R:R:Y223	20.4842	4.82	Yes	Yes	0	4	8
68	R:R:Q187	R:R:Y223	34.752	12.4	No	Yes	0	6	8
69	R:R:Q187	R:R:T135	36.6371	2.83	No	No	0	6	6
70	L:L:?1	R:R:T135	57.3391	5.74	Yes	No	0	0	6
71	R:R:M184	R:R:T135	21.8582	10.54	No	No	0	7	6
72	R:R:M184	R:R:Y132	12.3073	3.59	No	Yes	0	7	6
73	R:R:I176	R:R:V140	23.7433	3.07	No	No	0	6	7
74	R:R:V140	R:R:W177	27.0694	13.48	No	No	0	7	9
75	R:R:I176	R:R:L143	20.4005	9.99	No	No	0	6	6
76	R:R:L143	R:R:S146	17.0409	3	No	No	0	6	7
77	R:R:P235	R:R:S146	10.2714	1.78	No	No	0	9	7
78	R:R:F313	R:R:M239	43.3479	8.71	Yes	Yes	1	9	8
79	R:R:A149	R:R:M239	29.1555	3.22	No	Yes	1	8	8
80	R:R:M239	R:R:Y243	19.1773	3.59	Yes	Yes	1	8	9
81	R:R:A149	R:R:A242	31.9454	1.79	No	No	0	8	5
82	R:R:A242	R:R:W153	29.5744	2.59	No	Yes	0	5	8
83	R:R:L306	R:R:Y243	22.8971	7.03	No	Yes	0	8	9
84	R:R:H158	R:R:W153	10.0704	5.29	Yes	Yes	3	6	8
85	R:R:I246	R:R:L306	29.809	4.28	No	No	0	9	8
86	R:R:P186	R:R:Y223	12.0979	15.3	No	Yes	0	6	8
87	R:R:P220	R:R:W214	13.8153	21.62	No	Yes	0	5	4
88	R:R:F330	R:R:L326	12.3911	3.65	No	No	0	3	5
89	R:R:I322	R:R:L326	17.2336	2.85	No	No	0	5	5
90	R:R:I322	R:R:L318	19.6297	2.85	No	No	0	5	6
91	R:R:L318	R:R:P319	25.5865	6.57	No	No	0	6	9
92	R:R:L352	R:R:P319	19.1438	3.28	No	No	0	8	9
93	R:R:L352	R:R:W351	17.1833	3.42	No	Yes	0	8	5
94	L:L:?1	R:R:F227	12.4078	4.75	Yes	No	0	0	5
95	R:R:F227	R:R:T231	10.0788	14.27	No	No	0	5	6
96	R:R:F228	R:R:S321	10.5479	3.96	No	No	0	6	6
97	R:R:S321	R:R:Y232	13.1451	7.63	No	Yes	0	6	8
98	R:R:Y232	R:R:Y317	42.0744	3.97	Yes	Yes	0	8	7
99	R:R:L318	R:R:Y232	27.3961	3.52	No	Yes	0	6	8
100	R:R:I246	R:R:L250	25.8294	2.85	No	Yes	0	9	8
101	R:R:A303	R:R:F247	15.4658	2.77	No	No	0	7	6
102	R:R:A303	R:R:L250	17.6106	3.15	No	Yes	0	7	8
103	R:R:F247	R:R:W251	11.1344	12.03	No	No	0	6	5
104	R:R:I363	R:R:Y364	13.0865	3.63	No	Yes	1	8	9
105	R:R:I320	R:R:S349	11.9219	4.64	Yes	No	0	7	6
106	R:R:A358	R:R:V64	11.4192	1.7	No	No	0	5	7
107	R:R:L145	R:R:L96	20.3586	4.15	Yes	Yes	1	9	9
108	R:R:C107	R:R:Q134	44.814	7.63	No	Yes	0	7	7
109	R:R:T111	R:R:Y354	31.9286	9.99	Yes	Yes	0	7	7
110	R:R:H350	R:R:T111	21.9169	8.21	Yes	Yes	2	5	7
111	L:L:?1	R:R:I320	74.4554	7.78	Yes	Yes	2	0	7
112	R:R:L145	R:R:M239	10.7071	2.83	Yes	Yes	1	9	8
113	R:R:L306	R:R:R152	16.622	3.64	No	No	0	8	9
114	L:L:?1	R:R:Q134	36.9471	25.93	Yes	Yes	2	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q134	R:R:T106	2.83	2	Yes	No	7	5	1	2
R:R:C107	R:R:Q134	7.63	0	No	Yes	7	7	2	1
R:R:C107	R:R:Y354	6.72	0	No	Yes	7	7	2	2
R:R:T111	R:R:V114	3.17	2	Yes	No	7	5	1	2
R:R:D115	R:R:T111	2.89	2	Yes	Yes	5	7	2	1
R:R:Q134	R:R:T111	4.25	2	Yes	Yes	7	7	1	1
R:R:H350	R:R:T111	8.21	2	Yes	Yes	5	7	1	1
R:R:T111	R:R:Y354	9.99	2	Yes	Yes	7	7	1	2
L:L:?1	R:R:T111	3.45	2	Yes	Yes	0	7	0	1
R:R:D115	R:R:V114	2.92	2	Yes	No	5	5	2	2
R:R:D115	R:R:H350	10.08	2	Yes	Yes	5	5	2	1
R:R:F122	R:R:W120	11.02	0	No	Yes	6	7	2	1
R:R:C127	R:R:W120	7.84	2	No	Yes	9	7	2	1
R:R:C210	R:R:W120	13.06	2	No	Yes	9	7	2	1
L:L:?1	R:R:W120	7.99	2	Yes	Yes	0	7	0	1
R:R:C127	R:R:C210	5.46	2	No	No	9	9	2	2
R:R:I130	R:R:P131	3.39	0	No	No	5	5	2	1
R:R:I130	R:R:Q134	4.12	0	No	Yes	5	7	2	1
L:L:?1	R:R:P131	8.96	2	Yes	No	0	5	0	1
L:L:?1	R:R:Q134	25.93	2	Yes	Yes	0	7	0	1
R:R:M184	R:R:T135	10.54	0	No	No	7	6	2	1
R:R:Q187	R:R:T135	2.83	0	No	No	6	6	2	1
L:L:?1	R:R:T135	5.74	2	Yes	No	0	6	0	1
L:L:?1	R:R:V138	16.25	2	Yes	No	0	6	0	1
R:R:F227	R:R:T231	14.27	0	No	No	5	6	1	2
L:L:?1	R:R:F227	4.75	2	Yes	No	0	5	0	1
R:R:I320	R:R:S349	4.64	2	Yes	No	7	6	1	2
R:R:H350	R:R:I320	5.3	2	Yes	Yes	5	7	1	1
R:R:I320	R:R:V353	3.07	2	Yes	No	7	7	1	2
L:L:?1	R:R:I320	7.78	2	Yes	Yes	0	7	0	1
R:R:N324	R:R:R328	3.62	0	No	Yes	7	4	1	2
L:L:?1	R:R:N324	7.49	2	Yes	No	0	7	0	1
R:R:F346	R:R:H350	3.39	0	No	Yes	4	5	2	1
L:L:?1	R:R:H350	8.01	2	Yes	Yes	0	5	0	1
R:R:A110	R:R:Q134	1.52	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7SR8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.82
Number of Linked Nodes	267
Number of Links	291
Number of Hubs	34
Number of Links mediated by Hubs	126
Number of Communities	5
Number of Nodes involved in Communities	37
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	115
Number Of Links MetaPath	114
Number of Shortest Paths	42465
Length Of Smallest Path	3
Average Path Length	12.9565
Length of Longest Path	26
Minimum Path Strength	1.155
Average Path Strength	5.89425
Maximum Path Strength	22.51
Minimum Path Correlation	0.7
Average Path Correlation	0.928638
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	52.4043
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.3991
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • circadian sleep/wake cycle • multicellular organismal process • rhythmic behavior • circadian rhythm • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, wakefulness • regulation of circadian rhythm • behavior • regulation of behavior • circadian behavior • circadian sleep/wake cycle, wakefulness • regulation of multicellular organismal process • circadian sleep/wake cycle process • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • feeding behavior • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A6F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A6F
Name	Danavorexton
Synonyms	Methyl (2R,3S)-3-[(Methylsulfonyl)Amino]-2-{[(Cis-4-Phenylcyclohexyl)Oxy]Methyl}Piperidine-1-Carboxylate 1-piperidinecarboxylic acid, 3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)-, methyl ester, (2r,3s)- Methyl (2r,3s)-3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate Danavorexton
Identifier
Formula	C21 H32 N2 O5 S
Molecular Weight	424.554
SMILES
PubChem
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	2
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43614
Sequence	>7SR8_nogp_Chain_R P K E Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N H H M R T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E T W F F G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H P L M F K S T A K R A R N S I V I I W I V S C I I M I P Q A I V M E C S T V F L F T V C D E R W G G E I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C I K Q I R A R R K T A R M L M V V L L V F A I C Y L P I S I L N V L K R V F G M F A H T E D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F R E E F K A A F S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5WQC	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	1.96	2017-11-29	doi.org/10.1016/j.str.2017.11.005
	5WS3	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.3	2017-12-13	doi.org/10.1016/j.str.2017.11.005
	7XRR	A	Peptide	Orexin	OX₂	Homo sapiens	Lemborexant	-	-	2.89	2022-11-23	doi.org/10.1016/j.str.2022.11.001
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	4S0V	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.5	2015-01-14	doi.org/10.1038/nature14035
	7L1U	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7L1U (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-		3.2	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7L1V	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7L1V (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-		3	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7SQO	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	Gi1/β1/γ2	3.17	2022-05-25	doi.org/10.1038/s41467-022-30601-3
	7SQO (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.17	2022-05-25	doi.org/10.1038/s41467-022-30601-3
	7SR8	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.3	2022-06-08	doi.org/10.1038/s41467-022-30601-3
	7SR8 (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.3	2022-06-08	doi.org/10.1038/s41467-022-30601-3

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