Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N72 7.934219
2R:R:N82 7.4054106
3R:R:M85 5.4885108
4R:R:F92 4.452508
5R:R:L108 4.97407
6R:R:C127 6.15254199
7R:R:T144 5.1875407
8R:R:L145 4.7875449
9R:R:R152 5.0925409
10R:R:W153 8.546676208
11R:R:Y154 7.4575404
12R:R:I176 2.6575406
13R:R:M184 4.6775407
14R:R:E212 7.985154
15R:R:W214 11.27867154
16R:R:Y223 8.5325408
17R:R:H224 8.75254156
18R:R:F228 5.245226
19R:R:Y232 6.5154228
20R:R:L236 4.305406
21R:R:Y243 5.26649
22R:R:T302 4.06448
23R:R:L306 3.3675448
24R:R:F313 6.454549
25R:R:Y317 6.4125447
26R:R:I320 5.2445117
27R:R:V329 3.6875405
28R:R:F333 8.17754234
29R:R:V342 4.985405
30R:R:H350 9.25254115
31R:R:W351 4.3125405
32R:R:Y354 7.0365117
33R:R:N356 5.9175409
34R:R:I363 4.1975448
35R:R:Y364 5.49549
36R:R:F371 4.661437108
37R:R:F375 2.6945107
38A:A:V34 5.836575
39A:A:L36 4.724577
40A:A:L37 7.205419
41A:A:L38 4.8485258
42A:A:K46 3.303336259
43A:A:I49 4.18587
44A:A:I184 5.0775419
45A:A:F191 9.15475
46A:A:L194 6.5525474
47A:A:F196 7.925677
48A:A:F199 8.276515
49A:A:Q204 5.66519
50A:A:D206 7.4875418
51A:A:E207 8.84419
52A:A:R208 5.7419
53A:A:K210 7.96833619
54A:A:W211 6.04714719
55A:A:I212 4.752518
56A:A:C214 4.73417
57A:A:F215 7.816519
58A:A:V218 3.66419
59A:A:I221 5.22418
60A:A:C224 3.45407
61A:A:S228 7.94754269
62A:A:Y230 5.56333608
63A:A:M243 5.23498
64A:A:F250 7.7475409
65A:A:C254 4.9725405
66A:A:W258 7.58667615
67A:A:I265 3.605488
68A:A:F267 5.272589
69A:A:L268 5.6465168
70A:A:F274 6.9725409
71A:A:K277 7.97754269
72A:A:P282 4.21254275
73A:A:C286 5.9175496
74A:A:Y287 8.07875897
75A:A:E289 6.945496
76A:A:Y290 8.025407
77A:A:Y302 12.0675496
78A:A:Q306 11.0325495
79A:A:F307 7.0125408
80A:A:Y320 4.666587
81A:A:T321 8.274165
82A:A:F323 5.07404
83A:A:T324 9.54489
84A:A:Q333 4.065475
85A:A:F336 5.02833678
86A:A:V339 4.3975478
87A:A:V342 3.725407
88A:A:K345 7.29485
89A:A:L353 4.28447
90B:B:E10 4.66254298
91B:B:L14 3.724298
92B:B:L30 4.7375405
93B:B:T34 4.474125
94B:B:I37 4.19254122
95B:B:R48 4.0154137
96B:B:L51 7.37559
97B:B:H54 8.62333659
98B:B:Y59 12.155418
99B:B:M61 4.595456
100B:B:W63 7.38833657
101B:B:L70 6.1525455
102B:B:V71 4.1125408
103B:B:D76 6.685459
104B:B:K78 6.3975408
105B:B:I81 3.9985247
106B:B:W82 8.16286759
107B:B:N88 5.5575407
108B:B:K89 7.486559
109B:B:H91 5.9654245
110B:B:I93 6.82507
111B:B:W99 9.09719
112B:B:Y105 4.538506
113B:B:N110 5.42414
114B:B:Y111 5.678514
115B:B:L117 6.2725419
116B:B:C121 3.34418
117B:B:I123 4.398516
118B:B:Y124 7.168506
119B:B:H142 7.23167619
120B:B:Y145 5.775618
121B:B:C149 4.6725418
122B:B:F151 4.95143719
123B:B:L152 3.3565333
124B:B:I157 4.88667617
125B:B:V158 4.474335
126B:B:T159 5.33167619
127B:B:D163 8.52419
128B:B:T165 5.9675407
129B:B:L168 4.464506
130B:B:W169 9.37714718
131B:B:I171 4.515416
132B:B:F180 6.58667
133B:B:H183 8.656569
134B:B:D186 8.42519
135B:B:V187 4.5975469
136B:B:R197 5.3065175
137B:B:F199 9.7175469
138B:B:V200 5.875426
139B:B:S201 5.2625469
140B:B:C204 6.256517
141B:B:D205 6.9925469
142B:B:K209 9.54466
143B:B:L210 6.575405
144B:B:W211 9.192568
145B:B:D212 11.08754179
146B:B:E215 7.3354173
147B:B:Q220 11427
148B:B:F222 10.2775428
149B:B:H225 7.74571729
150B:B:D228 6.728519
151B:B:I229 4.415427
152B:B:I232 5.044528
153B:B:F235 6.513336146
154B:B:P236 5.2954147
155B:B:N237 5.99254145
156B:B:F241 6.59826
157B:B:T243 6.712528
158B:B:D247 7.618529
159B:B:T249 5.4775426
160B:B:R251 11.772528
161B:B:F253 7.845626
162B:B:D258 10.94427
163B:B:Y264 5.79833605
164B:B:I269 4.8254184
165B:B:F278 5.014297147
166B:B:S279 6.02439
167B:B:R283 8.8954129
168B:B:L286 5.4275437
169B:B:Y289 8.111676187
170B:B:N295 7.155186
171B:B:V296 3.962505
172B:B:L300 6.8654126
173B:B:L308 9.5775437
174B:B:H311 7.955639
175B:B:R314 11.5875418
176B:B:L318 4.47143736
177B:B:V320 3.1437
178B:B:V327 3.585436
179B:B:W332 10.8986719
180B:B:D333 8.22439
181B:B:K337 8.67436
182B:B:W339 7.95429739
183G:G:L19 3.455409
184G:G:R27 4.415408
185G:G:Y40 9.01254146
186G:G:D48 7.534539
187G:G:P49 3.835407
188G:G:L50 4.2875439
189G:G:N59 7.14754139
190G:G:P60 7.944139
191G:G:F61 4.705569138
192L:L:?1 9.7311110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F371 R:R:N365 12.784614.5YesNo087
2R:R:I93 R:R:N365 17.20038.5NoNo087
3R:R:I93 R:R:Y364 17.69063.63NoYes089
4R:R:F313 R:R:Y317 27.70837.22YesYes497
5R:R:V138 R:R:Y317 27.08763.79NoYes067
6L:L:?1 R:R:V138 26.84517.41YesNo006
7B:B:H311 B:B:T329 16.57066.85YesNo098
8B:B:L318 B:B:T329 17.23274.42YesNo068
9B:B:L318 B:B:S275 33.12123YesNo068
10B:B:S275 B:B:T274 33.23583.2NoNo088
11B:B:R314 B:B:T274 33.35053.88YesNo088
12A:A:W258 B:B:R314 32.20155YesYes158
13A:A:I212 A:A:W258 27.26053.52YesYes185
14A:A:F259 A:A:I212 57.32516.28NoYes198
15A:A:F259 A:A:I221 57.26768.79NoYes198
16A:A:I221 A:A:I264 1002.94YesNo086
17A:A:C254 A:A:I264 98.46024.91YesNo056
18A:A:C254 A:A:F250 97.95086.98YesYes059
19A:A:F250 A:A:F307 97.92436.43YesYes098
20A:A:F307 A:A:V225 95.73979.18YesNo087
21A:A:S246 A:A:V225 97.35614.85NoNo097
22A:A:A41 A:A:S246 97.31463.42NoNo079
23A:A:A41 A:A:S44 97.27313.42NoNo079
24A:A:K46 A:A:S44 34.92523.06YesNo099
25A:A:K46 A:A:L38 34.21165.64YesYes2598
26A:A:I222 A:A:L38 63.19395.71NoYes078
27A:A:F267 A:A:I222 54.94043.77YesNo097
28A:A:F267 A:A:I265 81.48243.77YesYes898
29A:A:I265 A:A:Y320 81.50333.63YesYes887
30A:A:K345 A:A:Y320 80.55035.97YesYes857
31A:A:K345 R:R:Q295 80.09882.71YesNo054
32R:R:Q295 R:R:R299 79.867822.2NoNo048
33R:R:L250 R:R:R299 78.71154.86NoNo088
34R:R:L250 R:R:T302 78.48014.42NoYes088
35R:R:L306 R:R:T302 76.08472.95YesYes488
36R:R:L306 R:R:Y243 71.9753.52YesYes489
37R:R:M239 R:R:Y243 35.6955.99NoYes489
38R:R:F313 R:R:M239 35.459911.2YesNo498
39A:A:C224 A:A:S44 62.30883.44YesNo079
40A:A:C224 A:A:L38 34.16013.17YesYes078
41A:A:C224 A:A:I49 28.04553.27YesYes077
42A:A:I49 A:A:T324 27.68924.56YesYes879
43A:A:F267 A:A:T324 27.498111.67YesYes899
44R:R:R152 R:R:Y243 17.03738.23YesYes099
45R:R:L236 R:R:Y232 11.7285.86YesYes068
46R:R:V309 R:R:Y243 11.40713.79NoYes489
47B:B:H54 B:B:I58 12.30357.95YesNo099
48B:B:G330 B:B:I58 15.14913.53NoNo059
49B:B:G330 B:B:H311 15.27563.18NoYes059
50A:A:F215 A:A:V218 42.533.93YesYes199
51A:A:I221 A:A:V218 42.75073.07YesYes189
52A:A:I212 A:A:W211 53.3214.7YesYes189
53A:A:F215 A:A:W211 42.24954.01YesYes199
54A:A:D206 A:A:W211 95.013810.05YesYes189
55A:A:D206 B:B:Y145 47.78498.05YesYes188
56A:A:D206 B:B:D186 47.63235.32YesYes189
57A:A:E207 B:B:D186 16.119615.59YesYes199
58A:A:K210 B:B:Y145 43.03663.58YesYes198
59B:B:C204 B:B:D186 16.11964.67YesYes179
60A:A:E207 B:B:D228 16.02373.9YesYes199
61B:B:C204 B:B:D228 16.02867.78YesYes179
62A:A:K210 B:B:D228 21.527611.06YesYes199
63A:A:K210 B:B:N230 21.39326.99YesNo099
64A:A:C214 A:A:H213 11.65212.95YesNo178
65A:A:C214 B:B:M101 17.59314.86YesNo079
66B:B:M101 B:B:Y145 17.5383.59NoYes098
67G:G:L19 G:G:Q18 10.81646.65YesNo099
68B:B:C218 G:G:Q18 11.30736.1NoNo059
69B:B:C218 B:B:W211 11.795.22NoYes658
70B:B:L168 B:B:V158 10.54154.47YesYes065
71B:B:L192 B:B:V158 21.80454.47NoYes3355
72B:B:L192 B:B:R150 23.02663.64NoNo056
73B:B:C148 B:B:R150 23.51066.96NoNo066
74B:B:C148 B:B:T102 23.75253.38NoNo068
75B:B:C149 B:B:T102 23.99446.76YesNo088
76B:B:C149 B:B:T159 24.14463.38YesYes189
77B:B:H142 B:B:T159 30.21816.85YesYes199
78B:B:H142 B:B:S161 41.122813.95YesNo199
79B:B:G162 B:B:S161 43.79393.71NoNo199
80B:B:G162 B:B:Y145 25.12344.35NoYes198
81B:B:L190 B:B:V158 11.03185.96NoYes055
82B:B:D186 B:B:G162 18.90815.03YesNo199
83B:B:F222 B:B:F253 12.690711.79YesYes286
84B:B:F253 B:B:H225 31.4734.53YesYes269
85B:B:D247 B:B:H225 68.56755.04YesYes299
86B:B:D247 B:B:S227 73.253910.31YesNo096
87B:B:D246 B:B:S227 73.71862.94NoNo096
88B:B:D228 B:B:D246 52.923.99YesNo099
89B:B:D246 B:B:N230 21.26344.04NoNo099
90B:B:C271 B:B:D290 10.16997.78NoNo056
91B:B:D290 B:B:R314 10.422715.48NoYes068
92B:B:V320 G:G:L50 13.06172.98YesYes379
93G:G:D48 G:G:P49 10.31334.83YesYes097
94G:G:D48 G:G:L50 12.01215.43YesYes399
95B:B:F241 B:B:T243 16.91253.89YesYes268
96B:B:H225 B:B:T243 25.36568.21YesYes298
97B:B:F241 B:B:F253 16.919812.86YesYes266
98B:B:D195 B:B:R197 13.16053.57NoYes055
99B:B:L198 B:B:R197 42.76814.86NoYes035
100B:B:L198 B:B:L210 46.05765.54NoYes035
101B:B:L210 B:B:V200 28.19334.47YesYes056
102B:B:I232 B:B:V200 15.03284.61YesYes286
103B:B:F241 B:B:V200 15.03735.24YesYes266
104B:B:L210 B:B:L255 14.09818.3YesNo056
105B:B:F241 B:B:L255 15.03753.65YesNo066
106B:B:D212 B:B:R197 13.16017.15YesYes1795
107B:B:R314 B:B:W332 11.591921.99YesYes189
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C107 R:R:Q134 6.1 0 No No 7 7 2 1
R:R:C107 R:R:Y354 8.06 0 No Yes 7 7 2 2
R:R:A110 R:R:Q134 3.03 0 No No 4 7 2 1
R:R:H350 R:R:T111 17.8 11 Yes No 5 7 1 2
R:R:T111 R:R:Y354 6.24 11 No Yes 7 7 2 2
L:L:?1 R:R:V114 4.64 11 Yes No 0 5 0 1
R:R:I130 R:R:P131 5.08 0 No No 5 5 2 1
L:L:?1 R:R:Q134 23.85 11 Yes No 0 7 0 1
R:R:M184 R:R:T135 6.02 0 Yes No 7 6 2 1
L:L:?1 R:R:T135 9.19 11 Yes No 0 6 0 1
R:R:V138 R:R:Y317 3.79 0 No Yes 6 7 1 2
L:L:?1 R:R:V138 17.41 11 Yes No 0 6 0 1
R:R:M184 R:R:Y223 4.79 0 Yes Yes 7 8 2 2
R:R:F227 R:R:M184 4.98 0 No Yes 5 7 1 2
R:R:E212 R:R:Q187 5.1 15 Yes No 4 6 2 1
R:R:Q187 R:R:Y223 4.51 0 No Yes 6 8 1 2
L:L:?1 R:R:Q187 4.15 11 Yes No 0 6 0 1
L:L:?1 R:R:F227 9.49 11 Yes No 0 5 0 1
L:L:?1 R:R:T231 8.04 11 Yes No 0 6 0 1
R:R:I320 R:R:P319 3.39 11 Yes No 7 9 1 2
R:R:I320 R:R:N324 4.25 11 Yes No 7 7 1 1
R:R:I320 R:R:S349 6.19 11 Yes No 7 6 1 2
R:R:I320 R:R:V353 4.61 11 Yes No 7 7 1 2
L:L:?1 R:R:I320 7.78 11 Yes Yes 0 7 0 1
L:L:?1 R:R:N324 13.91 11 Yes No 0 7 0 1
R:R:H350 R:R:S349 5.58 11 Yes No 5 6 1 2
R:R:H350 R:R:Y354 7.62 11 Yes Yes 5 7 1 2
L:L:?1 R:R:H350 6.01 11 Yes Yes 0 5 0 1
R:R:V353 R:R:Y354 5.05 0 No Yes 7 7 2 2
L:L:?1 R:R:P131 2.56 11 Yes No 0 5 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
69.23Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
66.67Single6TODEMPA6TOD-OX1-EMPA-Na
66.67Single7XRRLemborexant7XRR-OX2-Lemborexant
66.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
64.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
61.54Single4ZJCSB-6740424ZJC-OX1-SB-674042
61.54Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
61.54Single6TPNHTL66416TPN-OX2-HTL6641
61.54Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
61.54Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
61.54Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
61.54Single8GGKEpinephrine8GGK-β2-Epinephrine
61.54Single8GGMEpinephrine8GGM-β2-Epinephrine
61.54Single8GGPEpinephrine8GGP-β2-Epinephrine
61.54Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
61.54Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
60.00Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
60.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
60.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
60.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
60.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
60.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
60.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
60.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
58.33Single7SRQLSD7SRQ-5-HT2B-LSD
58.33Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
58.33Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
57.14Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
57.14Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
57.14Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
57.14Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
57.14Single6TOTLemborexant6TOT-OX1-Lemborexant
57.14Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
57.14Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
57.14Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
57.14Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
57.14Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GGJEpinephrine8GGJ-β2-Epinephrine
57.14Single8GGNEpinephrine8GGN-β2-Epinephrine
57.14Single8GGOEpinephrine8GGO-β2-Epinephrine
57.14Single8GGUEpinephrine8GGU-β2-Epinephrine
57.14Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
57.14Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
57.14Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
57.14Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
56.25Single4LDEBI1671074LDE-β2-BI167107
56.25Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
56.25Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
56.25Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
56.25Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
53.85Single5WS3EMPA5WS3-OX2-EMPA
53.85Single6AKXA4R6AKX-CCR5-A4R
53.85Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
53.85Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
53.85Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
53.85Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
53.85Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
53.85Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGWEpinephrine8GGW-β2-Epinephrine
53.85Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
53.85Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
53.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
53.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
53.33Single5WQCEMPA5WQC-OX2-EMPA
53.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
53.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
53.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
53.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
53.33Single6TP6Filorexant6TP6-OX1-Filorexant
53.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
53.33Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
53.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
53.33Single7WC6LSD7WC6-5-HT2A-LSD
53.33Single7XKAEpinephrine7XKA-β2-Epinephrine
53.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
53.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
53.33Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
53.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
53.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
53.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
53.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
53.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
53.33Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
52.94Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
52.94Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
52.94Single6H7LDobutamine6H7L-β1-Dobutamine
52.94Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
52.94Consensusendothelin_offOrthosteric Ligandetb_off
52.94Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
52.94Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
52.94Consensusorexin_onOrthosteric Ligandox2_on
50.00Single3P0GBI1671073P0G-β2-BI167107
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
50.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
50.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
50.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
50.00Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
50.00Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
50.00Single6E59L-7607356E59-NK1-L-760735
50.00Single6J20Aprepitant6J20-NK1-Aprepitant
50.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
50.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
50.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
50.00Single6TPGEMPA6TPG-OX2-EMPA
50.00Single6WGTLSD6WGT-5-HT2A-LSD
50.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
50.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
50.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
50.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
50.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
50.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
50.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
50.00Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGIEpinephrine8GGI-β2-Epinephrine
50.00Single8GGLEpinephrine8GGL-β2-Epinephrine
50.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
50.00Single8GGREpinephrine8GGR-β2-Epinephrine
50.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
50.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
50.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
50.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
50.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
50.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
50.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
50.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
47.37Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
47.37Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
47.37Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
47.37Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.06Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
47.06Single4AMIBucindolol4AMI-β1-Bucindolol
47.06Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
47.06Single6HLPNetupitant6HLP-NK1-Netupitant
47.06Single6MXTSalmeterol6MXT-β2-Salmeterol
47.06Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
47.06Single6ZG4HTL00099366ZG4-M1-HTL0009936
47.06Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
47.06Single7YITNalfurafine7YIT-κ-Nalfurafine
47.06Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
47.06Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
47.06Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8JJ8Formoterol8JJ8-β2-Formoterol
47.06Single8JJLOlodaterol8JJL-β2-Olodaterol
47.06Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
47.06Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
47.06Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
47.06Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
47.06Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
46.67Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
46.67Single2Y02Carmoterol2Y02-β1-Carmoterol
46.67Single2Y04Salbutamol2Y04-β1-Salbutamol
46.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
46.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
46.67Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
46.67Single4EJ4Naltrindole4EJ4-δ-Naltrindole
46.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
46.67Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
46.67Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
46.67Single6H7MSalbutamol6H7M-β1-Salbutamol
46.67Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
46.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
46.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
46.67Single6PS1Timolol6PS1-β2-Timolol
46.67Single7BU7BI1671077BU7-β1-BI167107
46.67Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
46.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.67Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
46.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
46.67Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
46.67Single7UL4Alvimopan7UL4-μ-Alvimopan
46.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
46.67Single7WC7Lisuride7WC7-5-HT2A-Lisuride
46.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
46.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
46.67Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8JJOAlprenolol8JJO-β2-Alprenolol
46.67Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
46.67Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
46.67Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8X63Mepyramine8X63-H1-Mepyramine
46.67Single8X64Desloratadine8X64-H1-Desloratadine
46.67Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
46.67Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
46.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
46.67Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
46.67Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
46.67Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
46.67Consensustachykinin_offOrthosteric Ligandnk1_off
46.67Consensustar_onOrthosteric Ligandta1_on
46.15Single6HLLCP999946HLL-NK1-CP99994
46.15Single6TP4ACT-4622066TP4-OX1-ACT-462206
46.15Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
46.15Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
46.15Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
46.15Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
46.15Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
46.15Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
46.15Single8GGSEpinephrine8GGS-β2-Epinephrine
46.15Single8GH1Epinephrine8GH1-β2-Epinephrine
46.15Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.15Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
44.44Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
44.44Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
44.44Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
44.44Single6IBLArformoterol6IBL-β1-Arformoterol
44.44Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
44.44Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
44.44Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
44.44Single7UM4AS26747237UM4-5-HT5A-AS2674723
44.44Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
44.44Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
44.44Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
44.44Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
44.44Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
43.75Single5C1MBU725C1M-μ-BU72
43.75Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
43.75Single5TVNLSD5TVN-5-HT2B-LSD
43.75Single5WIUNemonapride5WIU-D4-Nemonapride
43.75Single5WIVNemonapride5WIV-D4-Nemonapride-Na
43.75Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
43.75Single5XPRBosentan5XPR-ETB-Bosentan
43.75Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
43.75Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
43.75Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
43.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
43.75Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
43.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
43.75Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
43.75Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
43.75Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
43.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
43.75Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
43.75Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
43.75Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
43.75Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
43.75Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
43.75Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
43.75Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single4S0VSuvorexant4S0V-OX2-Suvorexant
42.86Single6AKYMaraviroc6AKY-CCR5-Maraviroc
42.86Single6B73PubChem 1319551386B73-κ-PubChem 131955138
42.86Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
42.86Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
42.86Single6TPJSuvorexant6TPJ-OX2-Suvorexant
42.86Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
42.86Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
42.86Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
42.86Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
42.86Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
42.86Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
42.86Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
42.86Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
42.86Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
42.86Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGVEpinephrine8GGV-β2-Epinephrine
42.86Single8GGXEpinephrine8GGX-β2-Epinephrine
42.86Single8GH0Epinephrine8GH0-β2-Epinephrine
42.86Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8IWESpermidine8IWE-TAAR9-Spermidine
42.86Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
42.86Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
42.86Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
42.86Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
42.86Consensusalpha1_onOrthosteric Ligandalpha1a_on
42.86Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
42.86Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
42.86Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
42.11Single3NY9PubChem 9131033NY9-β2-PubChem 913103
42.11Single5ZTYAM102575ZTY-CB2-AM10257
42.11Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
42.11Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
42.11Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
42.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
41.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
41.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single2YDVNECA2YDV-A2A-NECA
41.18Single4DJHJDTic4DJH-κ-JDTic
41.18Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
41.18Single4U15Tiotropium4U15-M3-Tiotropium
41.18Single4UHRCGS216804UHR-A2A-CGS21680
41.18Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
41.18Single5G53NECA5G53-A2A-NECA-Gs
41.18Single5X93K-87945X93-ETB-K-8794
41.18Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
41.18Single6OL9Tiotropium6OL9-M5-Tiotropium
41.18Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
41.18Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
41.18Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
41.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
41.18Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
41.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
41.18Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.18Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
41.18Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
41.18Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
41.18Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
41.18Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
41.18Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
41.18Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
41.18Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
41.18Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
41.18Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
40.91Single7C61Ergotamine7C61-5-HT1B-Ergotamine
40.00Single3RZECidoxepin3RZE-H1-Cidoxepin
40.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
40.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
40.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
40.00Single6A94Zotepine6A94-5-HT2A-Zotepine
40.00Single6IQLL7458706IQL-D4-L745870
40.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
40.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
40.00Single6TPKRetosiban6TPK-OT-Retosiban
40.00Single6V9SGTPL114036V9S-OX1-GTPL11403
40.00Single6VI4JDTic6VI4-κ-JDTic
40.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
40.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
40.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
40.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
40.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
40.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
40.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
40.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
40.00Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
40.00Single8GGTEpinephrine8GGT-β2-Epinephrine
40.00Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
40.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
40.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
40.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
40.00Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
40.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
40.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
40.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
40.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
40.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
40.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
39.13Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
39.13Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
38.89Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
38.89Single5CXVTiotropium5CXV-M1-Tiotropium
38.89Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
38.89Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
38.89Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.89Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
38.89Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
38.89Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
38.89Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
38.89Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single8WU1KCA8WU1-CB1-KCA-Arrestin1
38.89Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
38.89Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
38.89Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
38.89Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
38.89Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
38.46Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8GGZEpinephrine8GGZ-β2-Epinephrine
38.46Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
38.46Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
38.10Single6HLOAprepitant6HLO-NK1-Aprepitant
38.10Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
38.10Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
38.10Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.10Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
37.50Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
37.50Single4DAJTiotropium4DAJ-M3-Tiotropium
37.50Single4MQSIperoxo4MQS-M2-Iperoxo
37.50Single4U14Tiotropium4U14-M3-Tiotropium
37.50Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
37.50Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
37.50Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
37.50Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
37.50Single6DRXLisuride6DRX-5-HT2B-Lisuride
37.50Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
37.50Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
37.50Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
37.50Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
37.50Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
37.50Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
37.50Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
37.50Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
37.50Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
37.50Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
37.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
37.50Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
37.50Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
37.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
37.50Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
37.50Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
37.50Consensushistamine_onOrthosteric Ligandh1_on h4_on
37.50Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
37.50Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
37.50Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
36.84Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
36.84Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
36.84Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
36.84Single6K1QIRL25006K1Q-ETB-IRL2500
36.84Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
36.84Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
36.84Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.84Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
36.84Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
36.84Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
36.84Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
36.84Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.36Single6PT2KGCHM076PT2-δ-KGCHM07
36.36Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
36.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single3PBLEticlopride3PBL-D3-Eticlopride
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.71Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8GGYEpinephrine8GGY-β2-Epinephrine
35.71Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
35.71Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.71Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
35.71Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
35.71Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
35.71Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
35.29Single2Y00Dobutamine2Y00-β1-Dobutamine
35.29Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
35.29Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
35.29Single6PS6Timolol6PS6-β2-Timolol
35.29Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
35.29Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
35.29Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
35.29Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
35.29Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
35.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
35.29Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8EA0Iperoxo8EA0-M3-Iperoxo
35.29Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
35.29Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
35.29Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
35.29Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
35.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Single4UG2CGS216804UG2-A2A-CGS21680
35.00Single6PT3DPI-2876PT3-δ-DPI-287
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single7XN9L-054,5227XN9-SST2-L-054,522
35.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
35.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
35.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
35.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
35.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
34.62Single6IGLIRL16206IGL-ETB-IRL1620
34.62Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
34.62Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
33.33Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
33.33Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
33.33Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
33.33Single5DHHSB-6121115DHH-NOP-SB-612111
33.33Single5XR8AM8415XR8-CB1-AM841
33.33Single5XRAAM115425XRA-CB1-AM11542
33.33Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
33.33Single6J21Aprepitant6J21-NK1-Aprepitant
33.33Single6KUXRS-799486KUX-α2a-RS-79948
33.33Single6ME2Ramelteon6ME2-MT1-Ramelteon
33.33Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
33.33Single7F8ULintitript7F8U-CCKA-Lintitript
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
33.33Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
33.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
33.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
33.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
33.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
33.33Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
33.33Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
33.33Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
33.33Single8IHKAcifran8IHK-HCA3-Acifran
33.33Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
33.33Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
33.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
33.33Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
33.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
33.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
33.33Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
33.33Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
33.33Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
33.33Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
33.33Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
33.33Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
33.33Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
33.33Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
33.33Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
33.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Consensussst_onOrthosteric Ligandsst2_on sst4_on
32.14Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
32.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
32.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
32.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
32.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
31.82Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
31.82Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
31.82Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
31.82Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
31.82Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
31.58Single6CM4Risperidone6CM4-D2-Risperidone
31.58Single7DFPSpiperone7DFP-D2-Spiperone
31.58Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
31.58Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.58Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.58Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
31.58Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
31.58Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
31.58Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
31.58Single8JWZAB9288JWZ-A2A-AB928-Na
31.58Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
31.58Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
31.58Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
31.58Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.58Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.58Consensusgs_steroidOrthosteric Ligandgs_bileacid
31.58Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.58Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
31.58Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single2YDOAdenosine2YDO-A2A-Adenosine
31.25Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
31.25Single6DS0Ly2660976DS0-5-HT2B-Ly266097
31.25Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
31.25Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.25Single6ZG9GSK10347026ZG9-M1-GSK1034702
31.25Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
31.25Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.25Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
31.25Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.25Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
31.25Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
31.25Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
31.25Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
31.25Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
31.25Consensuss1p_offOrthosteric Ligands1p1_off
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
30.77Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
30.77Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
30.77Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single6W25SHU91196W25-MC4-SHU9119-Ca
30.43Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
30.43Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.43Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
30.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
30.43Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
30.43Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
30.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
30.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
30.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
30.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
30.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
30.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
30.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
30.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
30.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
30.00Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.00Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
30.00Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
30.00Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
30.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
30.00Consensussteroid_onOrthosteric Ligandbileacid_on
29.63Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
29.63Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
29.41Single2Y01Dobutamine2Y01-β1-Dobutamine
29.41Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
29.41Single4YAYZD-71554YAY-AT1-ZD-7155
29.41Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
29.41Single5DSGTiotropium5DSG-M4-Tiotropium
29.41Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
29.41Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
29.41Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
29.41Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
29.41Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
29.41Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
29.41Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.41Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
29.41Single8CU6LJ-45178CU6-A2A-LJ-4517
29.41Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
29.41Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
29.41Single8K5DGSK2560738K5D-HCA2-GSK256073
29.41Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
29.41Consensusadenosine_onOrthosteric Liganda1_on a2_on
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
29.41Consensuscck_offOrthosteric Ligandccka_off
29.41Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
29.41Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
29.41Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
29.41Consensusgi_hcarOrthosteric Ligandgi_hca
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
29.41Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
29.41Consensusleuko_onOrthosteric Ligandblt_on
29.41Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
29.41Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
29.41Consensusnucleotide_onOrthosteric Ligandadenosine_on
29.17Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
29.17Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
29.17Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single3OE6IT1t3OE6-CXCR4-IT1t
28.57Single3OE8IT1t3OE8-CXCR4-IT1t
28.57Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single6ME9Ramelteon6ME9-MT2-Ramelteon
28.57Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
28.57Single7SK9CCX6627SK9-ACKR3-CCX662
28.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.57Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
28.57Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
28.57Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
28.57Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.57Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
28.57Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
28.57Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
28.57Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
28.57Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
28.57Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
28.57Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
28.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
28.00Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.78Single6D26Fevipiprant6D26-DP2-Fevipiprant
27.78Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
27.78Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
27.78Single7C4SS1P7C4S-S1P3-S1P
27.78Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
27.78Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7SINNPS-21437SIN-CaS-NPS-2143
27.78Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
27.78Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
27.78Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
27.78Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
27.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
27.78Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
27.78Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
27.78Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
27.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
27.78Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
27.78Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.78Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
27.27Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
27.27Single7F8XNN90567F8X-CCKA-NN9056
27.27Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.27Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
27.27Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
27.27Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
27.27Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
26.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.92Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.92Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single3OE9IT1t3OE9-CXCR4-IT1t
26.67Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
26.67Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
26.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
26.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
26.67Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
26.67Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
26.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
26.67Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
26.67Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
26.67Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
26.32Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.32Single5V54Methiothepin5V54-5-HT1B-Methiothepin
26.32Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
26.32Single7EPENAM5637EPE-mGlu-NAM563
26.32Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
26.32Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
26.32Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.32Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
26.32Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
26.32Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
26.32Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
26.32Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
26.32Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
26.32Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
26.32Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
26.32Consensus5ht1_offOrthosteric Ligand5ht1b_off
26.32Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
26.32Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
26.32Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.32Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
26.32Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
26.09Single3QAKUK-4320973QAK-A2A-UK-432097
26.09Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
26.09Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
26.09Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
26.09Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
26.09Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.09Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
25.93Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.93Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.81Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
25.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
25.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
25.00Single3ODUIT1t3ODU-CXCR4-IT1t
25.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
25.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
25.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single6A93Risperidone6A93-5-HT2A-Risperidone
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
25.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
25.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
25.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
25.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
25.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
25.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
25.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
25.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
25.00Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
25.00Consensusdp_offOrthosteric Liganddp2_off
25.00Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
25.00Consensusgi_class-fOther Ligandgi_frizzled
25.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
25.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
25.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
25.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
25.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
25.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
24.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
24.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
24.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
24.00Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
24.00Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.81Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
23.81Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
23.81Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
23.81Single7EZCUKA7EZC-A2A-UKA
23.81Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
23.81Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.81Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
23.81Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
23.81Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
23.53Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
23.53Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
23.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.53Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
23.53Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
23.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
23.53Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
23.53Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
23.53Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.53Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
23.53Consensushca_onOrthosteric Ligandhca2_on hca3_on
23.53Consensushcar_onOrthosteric Ligandhca_on
23.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
23.08Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
23.08Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
23.08Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.08Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7WC4Serotonin7WC4-5-HT2A-Serotonin
23.08Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
23.08Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single8PWNTheophylline8PWN-A2A-Theophylline
23.08Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
23.08Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single5WF6UK-4320975WF6-A2A-UK-432097
22.73Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
22.73Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
22.73Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
22.73Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
22.73Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
22.73Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
22.73Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
22.73Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusclass-d_offOrthosteric Ligandste2_off
22.73Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
22.73Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
22.73Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
22.73Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
22.22Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
22.22Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
22.22Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single5UENDU1725UEN-A1-DU172
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6D27CAY104716D27-DP2-CAY10471
22.22Single6GPSMK08126GPS-CCR2-MK0812
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
22.22Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
22.22Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
22.22Single7F83PF-051904577F83-Ghrelin-PF-05190457
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
22.22Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
22.22Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
22.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
22.22Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
22.22Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
22.22Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.22Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
22.22Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
21.74Single4XT1Fractalkine4XT1-US28-Fractalkine
21.74Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
21.74Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
21.74Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
21.74Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
21.74Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
21.74Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
21.43Single3RFMCaffeine3RFM-A2A-Caffeine
21.43Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.43Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
21.43Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
21.43Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.43Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
21.43Consensussensory_onOrthosteric Ligandopsin_on
21.43Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.05Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
21.05Single5CGCHTL142425CGC-mGlu5-HTL14242
21.05Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
21.05Single5NM2ZM2413855NM2-A2A-ZM241385-Na
21.05Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
21.05Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.05Single6GPXMK08126GPX-CCR2-MK0812
21.05Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.05Single6LUQHaloperidol6LUQ-D2-Haloperidol
21.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Single8GNEKW-63568GNE-A2A-KW-6356-Na
21.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
21.05Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
21.05Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.83Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
20.83Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
20.83Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.69Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
20.69Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.69Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.69Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
20.00Single3OE0CVX153OE0-CXCR4-CVX15
20.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
20.00Single3UZAGTPL92363UZA-A2A-GTPL9236
20.00Single5TZR-5TZR-FFA1 (GPR40)-MK8666
20.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
20.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
20.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
20.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
20.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
20.00Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
20.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
20.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
20.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
19.35Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
19.23Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
19.23Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
19.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.23Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
19.23Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
19.05Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
19.05Single7K15MKD0467K15-BLT1-MKD046-Na
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
19.05Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
19.05Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
19.05Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
19.05Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
19.05Consensusblt_offOrthosteric Ligandblt1_off
19.05Consensusclass-b2_onOrthosteric Ligandadgrg_on
19.05Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.75Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
18.75Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
18.75Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
18.75Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
18.75Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
18.75Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
18.75Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
18.75Single8K5BNiacin8K5B-HCA2-Niacin
18.75Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.75Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Consensusclass-t_onOrthosteric Ligandtaste2_on
18.75Consensusgs_class-tOrthosteric Ligandgs_taste
18.75Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
18.75Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.52Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
18.52Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.52Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
18.52Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
18.52Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
18.52Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
18.18Single5CGDHTL142425CGD-mGlu5-HTL14242
18.18Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
18.18Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
18.18Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single4XT3Fractalkine4XT3-US28-Fractalkine
17.86Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
17.86Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7SK3CXCL127SK3-ACKR3-CXCL12
17.86Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
17.86Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
17.86Consensusclass-d_onOrthosteric Ligandste2_on
17.65Single3PWHZM2413853PWH-A2A-ZM241385
17.65Single5K2DZM2413855K2D-A2A-ZM241385
17.65Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
17.65Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single6JZHZM2413856JZH-A2A-ZM241385-Na
17.65Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single6PS7ZM2413856PS7-A2A-ZM241385-Na
17.65Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.65Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
17.65Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
17.65Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
17.65Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
17.65Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensusgt_class-aOrthosteric Ligandgt_opsin
17.65Consensusgt_opsinOrthosteric Ligandgt_sensory
17.65Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
17.65Consensuspth_onOrthosteric Ligandpth1_on pth2_on
17.39Single5EE7MK08935EE7-Glucagon-MK0893
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.39Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
17.39Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.24Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.24Consensusgi_class-dOrthosteric Ligandgi_ste
17.24Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.24Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single3REYPubChem 56973REY-A2A-PubChem 5697
16.67Single5IU4ZM2413855IU4-A2A-ZM241385-Na
16.67Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.67Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.67Single5JTBZM2413855JTB-A2A-ZM241385
16.67Single5K2BZM2413855K2B-A2A-ZM241385-Na
16.67Single5K2CZM2413855K2C-A2A-ZM241385-Na
16.67Single5NLXZM2413855NLX-A2A-ZM241385-Na
16.67Single5NM4ZM2413855NM4-A2A-ZM241385-Na
16.67Single6AQFZM2413856AQF-A2A-ZM241385
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
16.67Single6MH8ZM2413856MH8-A2A-ZM241385
16.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
16.67Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
16.67Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
16.67Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.67Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
16.67Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
16.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single7T32ZM2413857T32-A2A-ZM241385
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
16.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.67Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.67Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
16.67Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
16.67Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
16.67Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
16.67Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensusgnrh_offOrthosteric Ligandgnrh1_off
16.67Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
16.67Consensussensory_offOrthosteric Ligandopsin_off
16.13Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.00Single7SK5CXCL127SK5-ACKR3-CXCL12
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
16.00Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
15.79Single3EMLZM2413853EML-A2A-ZM241385
15.79Single4EIYZM2413854EIY-A2A-ZM241385-Na
15.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.79Single5K2AZM2413855K2A-A2A-ZM241385-Na
15.79Single5OLGZM2413855OLG-A2A-ZM241385-Na
15.79Single5VRAZM2413855VRA-A2A-ZM241385-Na
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.79Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.79Single6LPJZM2413856LPJ-A2A-ZM241385-Na
15.79Single6LPKZM2413856LPK-A2A-ZM241385-Na
15.79Single6S0LZM2413856S0L-A2A-ZM241385
15.79Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
15.79Single7PYRPSB-21157PYR-A2A-PSB-2115
15.79Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
15.79Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.79Consensusa2_offOrthosteric Liganda2a_off
15.79Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
15.79Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
15.79Consensushcar_offOrthosteric Ligandsuccinate_off
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.79Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
15.62Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.38Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.38Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
15.38Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
15.38Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.00Single6LPLZM2413856LPL-A2A-ZM241385-Na
15.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00Single6S0QZM2413856S0Q-A2A-ZM241385
15.00Single6WQAZM2413856WQA-A2A-ZM241385-Na
15.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7RM5ZM2413857RM5-A2A-ZM241385-Na
15.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
15.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.00Single8FYNZM2413858FYN-A2A-ZM241385-Na
15.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.00Single8QOTNanobody E8QOT-μ-Nanobody E
15.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
14.81Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
14.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.81Consensusclass-d_onOrthosteric Ligandste2_on
14.81Consensusgi_class-dOrthosteric Ligandgi_ste
14.81Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.71Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
14.71Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.29Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
14.29Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
14.29Single7P2L4YI7P2L-mGlu5-4YI
14.29Single7PX4PSB-21137PX4-A2A-PSB-2113
14.29Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
14.29Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
14.29Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.29Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
14.29Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
14.29Consensuschemerin_onOrthosteric Ligandcml1_on
14.29Consensusclass-c_onOther Ligandgabab_on mglu_on
14.29Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.79Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
13.79Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.64Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.64Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.64Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.64Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.64Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
13.64Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
13.64Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
13.64Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.64Consensuschemokine_offOrthosteric Ligandcxcr_off
13.64Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
13.64Consensuscxcr_offOrthosteric Ligandcxcr4_off
13.64Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.64Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
13.33Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
13.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
13.33Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
13.33Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.33Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
13.33Consensusgo_class-b1Orthosteric Ligandgo_crf
13.33Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.33Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
13.04Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.04Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.04Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.04Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.04Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.04Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.90Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon
12.90Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.90Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.90Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.50Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
12.50Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
12.50Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.50Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
12.50Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
12.50Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.50Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
12.50Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.50Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.12Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
12.12Consensusglp_onOrthosteric Ligandglp1_on glp2_on
12.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
12.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.76Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
11.76Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
11.76Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.76Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
11.76Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
11.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.76Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.76Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.54Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.54Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.54Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Consensussst_offOrthosteric Ligandsst2_off
11.43Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
11.11Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.11Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.11Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.11Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
11.11Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
11.11Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.71Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
10.53Single5UVIZM2413855UVI-A2A-ZM241385
10.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.53Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.53Single6ZINSR486926ZIN-NTS1-SR48692
10.53Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.53Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
10.53Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.53Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.53Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.53Single8K2WAMG4878K2W-CXCR3-AMG487
10.53Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
10.53Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
10.34Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
10.34Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
10.34Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
10.34Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.34Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
10.26Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
10.00Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
10.00Single6FFHFenobam6FFH-mGlu5-Fenobam
10.00Single6FJ3PTH6FJ3-PTH1-PTH
10.00Single6IIVDaltroban6IIV-TP-Daltroban
10.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
10.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
10.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
10.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
10.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
10.00Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
10.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
9.76Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
9.68Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
9.68Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
9.68Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
9.52Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
9.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.52Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.52Single6Z4SSR486926Z4S-NTS1-SR48692
9.52Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.52Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
9.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.52Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.52Consensusep_offOrthosteric Ligandep4_off
9.38Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
9.38Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
9.38Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.38Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
9.09Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
9.09Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.09Single5V56TC1145V56-SMO-TC114
9.09Single6OS1TRV0266OS1-AT1-TRV026
9.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.09Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
9.09Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
9.09Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Consensusclass-c_offOther Ligandgabab_off mglu_off
9.09Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.09Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.70Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
8.70Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.70Single4XESNeurotensin4XES-NTS1-Neurotensin
8.70Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.70Single6IIURamatroban6IIU-TP-Ramatroban
8.70Single6OS2TRV0266OS2-AT1-TRV026
8.70Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
8.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
8.70Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.70Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.70Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.70Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
8.70Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.70Consensusnts_offOrthosteric Ligandnts1_off
8.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
8.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
8.57Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
8.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
8.33Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
8.33Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.33Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
8.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
8.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
7.69Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.69Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
7.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.41Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single6W25Ca6W25-MC4-SHU9119-Ca
7.14Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
6.90Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
6.90Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
6.67Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
6.67Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
6.67Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
6.45Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
6.45Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.45Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.25Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.25Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.25Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.25Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.06Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
5.88Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.88Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.88Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.88Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.88Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.88Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
5.56Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.56Single5L7IVismodegib5L7I-SMO-Vismodegib
5.56Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.56Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
5.56Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.41Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
5.26Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.26Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.26Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.26Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.26Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.26Single8G94CD698G94-S1P1-CD69-Gi1/&β;1/&γ;2
5.26Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.26Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.13Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.00Single7VV6C48/807VV6-MRGPRX2-C48/80
5.00Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.88Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.76Single5T04Neurotensin5T04-NTS1-Neurotensin
4.76Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.76Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.76Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.76Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.76Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.55Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.55Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.35Single5V57TC1145V57-SMO-TC114
4.35Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.35Single7F1TMIP-1a7F1T-CCR5-MIP-1a
4.17Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.17Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.17Single7SHEPI; PE7SHE-GPR158-PI; PE
4.17Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Consensusnts_onOrthosteric Ligandnts1_on
4.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
3.70Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.70Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.70Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.12Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.12Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.03Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.03Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.03Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.94Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
2.94Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
2.94Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
2.86Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.78Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.50Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.38Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.33Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.33Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7SQO
Class A
SubFamily Peptide
Type Orexin
SubType OX2
Species Homo sapiens
Ligand TAK-925
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.17
Date 2022-05-25
D.O.I. 10.1038/s41467-022-30601-3
Net Summary
Imin 2.94
Number of Linked Nodes 835
Number of Links 1051
Number of Hubs 192
Number of Links mediated by Hubs 684
Number of Communities 33
Number of Nodes involved in Communities 257
Number of Links involved in Communities 378
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 4677403
Length Of Smallest Path 3
Average Path Length 36.2264
Length of Longest Path 67
Minimum Path Strength 1.345
Average Path Strength 5.96156
Maximum Path Strength 23.255
Minimum Path Correlation 0.7
Average Path Correlation 0.990122
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 32.4167
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.7533
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeA6F
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeA6F
NameDanavorexton
Synonyms
  • Methyl (2R,3S)-3-[(Methylsulfonyl)Amino]-2-{[(Cis-4-Phenylcyclohexyl)Oxy]Methyl}Piperidine-1-Carboxylate
  • Methyl (2r,3s)-3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate
  • 1-piperidinecarboxylic acid, 3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)-, methyl ester, (2r,3s)-
  • Danavorexton
Identifiermethyl (2~{R},3~{S})-3-(methylsulfonylamino)-2-[(4-phenylcyclohexyl)oxymethyl]piperidine-1-carboxylate
FormulaC21 H32 N2 O5 S
Molecular Weight424.554
SMILESCOC(=O)N1CCC[C@@H]([C@@H]1COC2CCC(CC2)c3ccccc3)NS(=O)(=O)C
PubChem
Formal Charge0
Total Atoms61
Total Chiral Atoms2
Total Bonds63
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO43614
Sequence
>7SQO_Chain_R
WVLIAGYII VFVVALIGN VLVCVAVWK NHHMRTVTN YFIVNLSLA 
DVLVTITCL PATLVVDIT ETWFFGQSL CKVIPYLQT VSVSVSVLT 
LSCIALDRW YAICHPLMF KSTAKRARN SIVIIWIVS CIIMIPQAI 
VMECSTVCD ERWGGEIYP KMYHICFFL VTYMAPLCL MVLAYLQIF 
RKLWCRQII KQIRARRKT ARMLMVVLL VFAICYLPI SILNVLKRV 
FGMFRETVY AWFTFSHWL VYANSAANP IIYNFLSGK FREEFKAAF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7SQO_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKITGI VETHFTFKD LHFKMFDVG GQRDERKKW IHCFEGVTA 
IIFCVALSD YDLVNRMHE SMKLFDSIC NNKWFTDTS IILFLNKKD 
LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE DLNKRKDTK 
EIYTHFTCS TDTKNVQFV FDAVTDVII KNNLKDCGL F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7SQO_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7SQO_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4S0VAPeptideOrexinOX2Homo sapiensSuvorexant--2.52015-01-1410.1038/nature14035
5WQCAPeptideOrexinOX2Homo sapiensEMPA--1.962017-11-2910.1016/j.str.2017.11.005
5WS3APeptideOrexinOX2Homo sapiensEMPA--2.32017-12-1310.1016/j.str.2017.11.005
6TPGAPeptideOrexinOX2Homo sapiensEMPA--2.742020-01-0110.1021/acs.jmedchem.9b01787
6TPJAPeptideOrexinOX2Homo sapiensSuvorexant--2.742020-01-0110.1021/acs.jmedchem.9b01787
6TPNAPeptideOrexinOX2Homo sapiensHTL6641--2.612020-01-0110.1021/acs.jmedchem.9b01787
7L1UAPeptideOrexinOX2Homo sapiensOrexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.22021-02-1010.1038/s41467-021-21087-6
7L1VAPeptideOrexinOX2Homo sapiensPubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;232021-02-1010.1038/s41467-021-21087-6
7SR8APeptideOrexinOX2Homo sapiensTAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;23.32022-06-0810.1038/s41467-022-30601-3
7XRRAPeptideOrexinOX2Homo sapiensLemborexant--2.892022-11-2310.1016/j.str.2022.11.001




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