psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E54	R:R:K51	5.4	No	No	0	7	4
2	R:R:E52	R:R:W55	5.45	No	No	0	3	4
3	R:R:E54	R:R:Y53	4.49	No	No	0	7	4
4	R:R:E54	R:R:L57	3.98	No	No	0	7	5
5	R:R:L57	R:R:Y61	7.03	No	Yes	1	5	7
6	R:R:L57	R:R:T347	7.37	No	No	1	5	4
7	R:R:G60	R:R:I63	3.53	No	No	0	4	3
8	R:R:L108	R:R:Y61	7.03	Yes	Yes	1	7	7
9	R:R:L112	R:R:Y61	12.89	No	Yes	0	6	7
10	R:R:T347	R:R:Y61	3.75	No	Yes	1	4	7
11	R:R:W351	R:R:Y61	9.65	No	Yes	0	5	7
12	R:R:Y354	R:R:Y61	4.96	Yes	Yes	1	7	7
13	R:R:V64	R:R:W351	6.13	No	No	0	7	5
14	R:R:F65	R:R:L69	3.65	No	Yes	0	6	6
15	R:R:F65	R:R:L108	8.53	No	Yes	0	6	7
16	R:R:A68	R:R:T104	3.36	No	No	0	8	7
17	R:R:I105	R:R:L69	4.28	No	Yes	0	4	6
18	R:R:N72	R:R:S97	8.94	No	No	0	9	9
19	R:R:D100	R:R:N72	6.73	Yes	No	0	9	9
20	R:R:N72	R:R:P361	9.77	No	No	0	9	9
21	R:R:S97	R:R:V75	3.23	No	No	0	9	9
22	R:R:N365	R:R:V75	5.91	No	No	0	7	9
23	R:R:V79	R:R:V94	4.81	No	No	0	7	6
24	R:R:A378	R:R:K81	3.21	No	No	0	6	6
25	R:R:H84	R:R:N82	3.83	No	Yes	0	5	6
26	R:R:M85	R:R:N82	5.61	Yes	Yes	0	8	6
27	R:R:A378	R:R:N82	3.13	No	Yes	0	6	6
28	R:R:H83	R:R:R86	20.31	No	No	0	7	8
29	R:R:F371	R:R:M85	4.98	Yes	Yes	0	8	8
30	R:R:E374	R:R:M85	5.41	No	Yes	0	7	8
31	R:R:S164	R:R:V88	3.23	No	No	0	5	6
32	R:R:I93	R:R:N90	5.66	No	No	0	8	9
33	R:R:C147	R:R:F92	5.59	No	Yes	0	6	8
34	R:R:F92	R:R:I148	3.77	Yes	No	0	8	8
35	R:R:I93	R:R:N365	9.91	No	No	0	8	7
36	R:R:N95	R:R:T144	5.85	No	No	0	9	7
37	R:R:I173	R:R:N95	7.08	No	No	0	8	9
38	R:R:N95	R:R:W177	5.65	No	No	0	9	9
39	R:R:D100	R:R:L96	5.43	Yes	No	0	9	9
40	R:R:L96	R:R:T144	4.42	No	No	0	9	7
41	R:R:L145	R:R:L96	5.54	No	No	0	9	9
42	R:R:A99	R:R:V140	3.39	No	No	0	8	7
43	R:R:D100	R:R:S357	5.89	Yes	No	0	9	9
44	R:R:D100	R:R:N360	10.77	Yes	No	0	9	9
45	R:R:L102	R:R:S137	6.01	No	No	0	6	5
46	R:R:C107	R:R:V103	5.12	Yes	No	0	7	7
47	R:R:S357	R:R:V103	6.46	No	No	0	9	7
48	R:R:C107	R:R:Q134	9.16	Yes	No	0	7	7
49	R:R:C107	R:R:Y354	4.03	Yes	Yes	0	7	7
50	R:R:L108	R:R:P109	3.28	Yes	No	0	7	8
51	R:R:L108	R:R:Y354	12.89	Yes	Yes	1	7	7
52	R:R:D115	R:R:T111	5.78	Yes	No	1	5	7
53	R:R:H350	R:R:T111	5.48	Yes	No	1	5	7
54	R:R:T111	R:R:Y354	4.99	No	Yes	1	7	7
55	R:R:T117	R:R:V113	3.17	No	No	0	5	4
56	R:R:D115	R:R:T347	8.67	Yes	No	1	5	4
57	R:R:D115	R:R:H350	5.04	Yes	Yes	1	5	5
58	R:R:T117	R:R:T119	10.99	No	No	0	5	5
59	R:R:E118	R:R:R339	6.98	No	No	0	4	1
60	R:R:E118	R:R:Y343	4.49	No	No	0	4	3
61	R:R:F121	R:R:T119	3.89	No	No	0	4	5
62	R:R:F207	R:R:T119	10.38	No	No	0	3	5
63	R:R:F122	R:R:W120	15.03	No	Yes	0	6	7
64	R:R:C127	R:R:W120	7.84	No	Yes	3	9	7
65	R:R:C193	R:R:W120	3.92	No	Yes	3	4	7
66	R:R:C210	R:R:W120	18.28	No	Yes	3	9	7
67	L:L:L7	R:R:W120	3.42	No	Yes	0	0	7
68	R:R:F122	R:R:L126	6.09	No	No	0	6	5
69	R:R:C127	R:R:C193	3.64	No	No	3	9	4
70	R:R:C127	R:R:C210	7.28	No	No	3	9	9
71	R:R:I130	R:R:P131	3.39	Yes	No	0	5	5
72	R:R:I130	R:R:Q134	4.12	Yes	No	0	5	7
73	R:R:M191	R:R:P131	5.03	No	No	0	6	5
74	R:R:V136	R:R:Y132	7.57	No	No	0	5	6
75	R:R:A188	R:R:Y132	4	No	No	0	6	6
76	L:L:L7	R:R:Q134	6.65	No	No	0	0	7
77	R:R:M184	R:R:T135	9.03	Yes	No	0	7	6
78	R:R:Q187	R:R:T135	7.09	Yes	No	0	6	6
79	L:L:M9	R:R:V138	7.61	No	No	0	0	6
80	R:R:S139	R:R:S180	3.26	No	No	0	7	8
81	R:R:V140	R:R:W177	12.26	No	No	0	7	9
82	R:R:S180	R:R:V140	3.23	No	No	0	8	7
83	R:R:P235	R:R:V142	3.53	No	No	0	9	8
84	R:R:F313	R:R:V142	3.93	Yes	No	4	9	8
85	R:R:V142	R:R:Y317	5.05	No	No	4	8	7
86	R:R:I176	R:R:L143	4.28	No	No	0	6	6
87	R:R:F313	R:R:L145	3.65	Yes	No	0	9	9
88	R:R:L145	R:R:Y364	8.21	No	Yes	0	9	9
89	R:R:P235	R:R:S146	3.56	No	No	0	9	7
90	R:R:C147	R:R:I176	4.91	No	No	0	6	6
91	R:R:I148	R:R:R152	5.01	No	No	0	8	9
92	R:R:I148	R:R:Y364	6.04	No	Yes	0	8	9
93	R:R:A149	R:R:Y243	6.67	No	Yes	0	8	9
94	R:R:D151	R:R:S164	7.36	No	No	0	9	5
95	R:R:R152	R:R:Y243	6.17	No	Yes	0	9	9
96	R:R:W153	R:R:Y154	6.75	Yes	No	0	8	4
97	R:R:C157	R:R:W153	7.84	No	Yes	0	7	8
98	R:R:H158	R:R:W153	7.41	No	Yes	0	6	8
99	R:R:A242	R:R:W153	3.89	No	Yes	0	5	8
100	R:R:Q245	R:R:W153	10.95	No	Yes	0	5	8
101	R:R:K163	R:R:Y154	10.75	No	No	6	5	4
102	R:R:R168	R:R:Y154	6.17	No	No	6	7	4
103	R:R:I156	R:R:I246	8.83	No	No	7	8	9
104	R:R:C157	R:R:I246	3.27	No	No	0	7	9
105	R:R:H158	R:R:M161	7.88	No	No	0	6	5
106	R:R:L160	R:R:P159	3.28	No	No	0	7	9
107	R:R:K163	R:R:M161	4.32	No	No	0	5	5
108	R:R:K163	R:R:R168	7.43	No	No	6	5	7
109	R:R:K167	R:R:N171	6.99	No	No	0	5	3
110	R:R:N171	R:R:R170	4.82	No	No	0	3	4
111	R:R:I183	R:R:M184	4.37	No	Yes	0	5	7
112	R:R:F227	R:R:M184	4.98	No	Yes	0	5	7
113	R:R:I185	R:R:P186	3.39	No	No	0	5	6
114	R:R:P186	R:R:Y223	19.47	No	Yes	0	6	8
115	R:R:M191	R:R:Q187	4.08	No	Yes	2	6	6
116	R:R:E212	R:R:Q187	3.82	Yes	Yes	2	4	6
117	L:L:T8	R:R:Q187	4.25	No	Yes	0	0	6
118	R:R:E212	R:R:V190	7.13	Yes	No	2	4	6
119	R:R:V190	R:R:W214	9.81	No	Yes	2	6	4
120	R:R:E212	R:R:M191	4.06	Yes	No	2	4	6
121	R:R:E192	R:R:R213	23.26	No	No	0	5	4
122	R:R:T195	R:R:T208	7.85	No	No	0	2	3
123	R:R:F207	R:R:T208	7.78	No	No	0	3	3
124	L:L:G5	R:R:V209	3.68	No	No	0	0	5
125	R:R:D211	R:R:R328	9.53	No	No	0	5	4
126	L:L:G5	R:R:D211	5.03	No	No	0	0	5
127	R:R:E212	R:R:W214	14.17	Yes	Yes	2	4	4
128	R:R:E212	R:R:H224	8.62	Yes	No	0	4	6
129	R:R:P220	R:R:W214	25.67	No	Yes	0	5	4
130	R:R:W214	R:R:Y223	6.75	Yes	Yes	0	4	8
131	R:R:H224	R:R:Y223	5.44	No	Yes	0	6	8
132	R:R:H224	R:R:R328	11.28	No	No	0	6	4
133	R:R:F227	R:R:T231	7.78	No	No	0	5	6
134	L:L:M9	R:R:F227	3.73	No	No	0	0	5
135	R:R:F228	R:R:Y232	7.22	No	Yes	0	6	8
136	R:R:F228	R:R:V325	3.93	No	No	0	6	6
137	R:R:L236	R:R:Y232	4.69	No	Yes	0	6	8
138	R:R:L318	R:R:Y232	4.69	No	Yes	0	6	8
139	R:R:S321	R:R:Y232	7.63	No	Yes	0	6	8
140	R:R:C237	R:R:M233	3.24	No	No	0	4	5
141	R:R:M239	R:R:Y243	3.59	No	Yes	0	8	9
142	R:R:F313	R:R:M239	8.71	Yes	No	0	9	8
143	R:R:L306	R:R:Y243	8.21	No	Yes	0	8	9
144	R:R:F247	R:R:W251	15.03	No	No	0	6	5
145	R:R:A303	R:R:F247	4.16	No	No	0	7	6
146	R:R:F247	R:R:M307	6.22	No	No	0	6	6
147	R:R:R300	R:R:W251	19.99	No	No	0	5	5
148	R:R:Q295	R:R:R299	3.5	No	No	0	4	8
149	R:R:K301	R:R:R304	13.61	No	No	0	8	8
150	R:R:I363	R:R:V309	4.61	Yes	No	5	8	8
151	R:R:V309	R:R:Y364	5.05	No	Yes	5	8	9
152	R:R:F313	R:R:Y317	6.19	Yes	No	4	9	7
153	R:R:C316	R:R:N356	6.3	No	No	0	8	9
154	R:R:N356	R:R:Y317	9.3	No	No	0	9	7
155	R:R:L318	R:R:P319	4.93	No	No	0	6	9
156	R:R:P319	R:R:S349	3.56	No	No	0	9	6
157	R:R:L352	R:R:P319	3.28	No	No	0	8	9
158	R:R:I320	R:R:S349	3.1	No	No	0	7	6
159	R:R:H350	R:R:I320	5.3	Yes	No	0	5	7
160	R:R:I320	R:R:V353	4.61	No	No	0	7	7
161	R:R:F346	R:R:L323	9.74	Yes	No	0	4	5
162	L:L:T8	R:R:N324	8.77	No	No	0	0	7
163	R:R:K327	R:R:R328	18.56	No	No	0	3	4
164	R:R:F333	R:R:K327	3.72	Yes	No	0	4	3
165	R:R:F346	R:R:K327	3.72	Yes	No	0	4	3
166	R:R:F330	R:R:V329	3.93	No	No	0	3	5
167	R:R:F333	R:R:V342	11.8	Yes	No	0	4	5
168	R:R:A334	R:R:H335	4.39	No	No	0	2	1
169	R:R:D338	R:R:T336	4.34	No	No	0	3	4
170	L:L:H2	R:R:T336	6.85	No	No	0	0	4
171	R:R:D338	R:R:T341	5.78	No	No	0	3	4
172	L:L:H2	R:R:R339	18.05	No	No	0	0	1
173	R:R:E340	R:R:T341	4.23	No	No	0	1	4
174	L:L:I6	R:R:Y343	4.84	No	No	0	0	3
175	R:R:F346	R:R:H350	5.66	Yes	Yes	0	4	5
176	L:L:I6	R:R:F346	7.54	No	Yes	0	0	4
177	R:R:F348	R:R:L352	4.87	No	No	0	4	8
178	R:R:A355	R:R:W351	5.19	No	No	0	4	5
179	R:R:V353	R:R:Y354	3.79	No	Yes	0	7	7
180	R:R:N356	R:R:N360	9.54	No	No	0	9	9
181	R:R:I363	R:R:Y364	4.84	Yes	Yes	5	8	9
182	R:R:F371	R:R:N365	6.04	Yes	No	0	8	7
183	R:R:F366	R:R:F371	5.36	No	Yes	0	5	8
184	R:R:E374	R:R:K370	17.55	No	No	0	7	7
185	R:R:I189	R:R:V190	3.07	No	No	0	5	6
186	R:R:I363	R:R:V312	3.07	Yes	No	0	8	6
187	R:R:I116	R:R:T117	3.04	No	No	0	5	5
188	R:R:M184	R:R:V136	3.04	Yes	No	0	7	5
189	R:R:L126	R:R:S125	3	No	No	0	5	3
190	R:R:L238	R:R:S146	3	No	No	0	7	7
191	R:R:G369	R:R:R372	3	No	No	0	5	8
192	R:R:L69	R:R:V101	2.98	Yes	No	0	6	7
193	R:R:L310	R:R:V240	2.98	No	No	0	8	5
194	R:R:L69	R:R:T104	2.95	Yes	No	0	6	7
195	R:R:L250	R:R:T302	2.95	Yes	No	0	8	8
196	R:R:L306	R:R:T302	2.95	No	No	0	8	8
197	R:R:D115	R:R:V114	2.92	Yes	No	0	5	5
198	R:R:I70	R:R:L74	2.85	No	No	0	4	6
199	R:R:I116	R:R:L112	2.85	No	No	0	5	6
200	R:R:I156	R:R:L250	2.85	No	Yes	7	8	8
201	R:R:I246	R:R:L250	2.85	No	Yes	7	9	8
202	R:R:I322	R:R:L318	2.85	No	No	0	5	6
203	R:R:I362	R:R:L367	2.85	No	No	0	6	7
204	R:R:L229	R:R:M233	2.83	No	No	0	4	5
205	R:R:L310	R:R:M239	2.83	No	No	0	8	8
206	R:R:L367	R:R:M305	2.83	No	No	0	7	8
207	R:R:L310	R:R:M307	2.83	No	No	0	8	6
208	R:R:K249	R:R:L250	2.82	No	Yes	0	5	8
209	R:R:A78	R:R:F375	2.77	No	No	0	8	7
210	R:R:A169	R:R:F92	2.77	No	Yes	0	7	8
211	L:L:A3	R:R:F333	2.77	No	Yes	0	0	4
212	R:R:C181	R:R:Y132	2.69	No	No	0	4	6
213	R:R:A169	R:R:Y91	2.67	No	No	0	7	4
214	R:R:F92	R:R:S172	2.64	Yes	No	0	8	6
215	R:R:I296	R:R:R300	2.51	No	No	0	4	5
216	R:R:F228	R:R:M233	2.49	No	No	0	6	5
217	R:R:F333	R:R:M332	2.49	Yes	No	0	4	3
218	R:R:V77	R:R:W80	2.45	No	No	0	5	3
219	R:R:F375	R:R:L74	2.44	No	No	0	7	6
220	R:R:T341	R:R:W345	2.43	No	No	0	4	5
221	R:R:R297	R:R:R300	2.13	No	No	0	5	5
222	R:R:G215	R:R:G216	2.11	No	No	0	4	5
223	R:R:A59	R:R:G60	1.95	No	No	0	4	4
224	R:R:W214	R:R:Y219	1.93	Yes	No	0	4	3
225	R:R:A234	R:R:P235	1.87	No	No	0	5	9
226	R:R:A358	R:R:A68	1.79	No	No	0	5	8
227	R:R:G71	R:R:I70	1.76	No	No	0	8	4
228	R:R:C76	R:R:S97	1.72	No	No	0	6	9
229	R:R:A99	R:R:S141	1.71	No	No	0	8	9
230	R:R:A166	R:R:V88	1.7	No	No	0	3	6
231	L:L:A4	R:R:V209	1.7	No	No	0	0	5
232	R:R:C107	R:R:T106	1.69	Yes	No	0	7	5
233	R:R:E217	R:R:G216	1.64	No	No	0	3	5
234	R:R:S137	R:R:V103	1.62	No	No	0	5	7
235	R:R:A110	R:R:I130	1.62	No	Yes	0	4	5
236	R:R:S194	R:R:V196	1.62	No	No	0	3	3
237	R:R:S194	R:R:V209	1.62	No	No	0	3	5
238	R:R:A78	R:R:M85	1.61	No	Yes	0	8	8
239	R:R:A298	R:R:K294	1.61	No	No	0	6	3
240	R:R:V101	R:R:V73	1.6	No	No	0	7	4
241	R:R:V308	R:R:V312	1.6	No	No	0	6	6
242	R:R:V325	R:R:V329	1.6	No	No	0	6	5
243	R:R:C76	R:R:L98	1.59	No	No	0	6	5
244	R:R:T89	R:R:V88	1.59	No	No	0	8	6
245	R:R:A314	R:R:L236	1.58	No	No	0	5	6
246	R:R:A377	R:R:N82	1.56	No	Yes	0	4	6
247	L:L:N1	R:R:A334	1.56	No	No	0	0	2
248	L:L:A4	L:L:N1	1.56	No	No	0	0	0
249	R:R:I63	R:R:V64	1.54	No	No	0	3	7
250	R:R:I130	R:R:V129	1.54	Yes	No	0	5	4
251	R:R:I178	R:R:V174	1.54	No	No	0	3	3
252	R:R:I175	R:R:V179	1.54	No	No	0	3	5
253	R:R:H49	R:R:P50	1.53	No	No	0	4	5
254	R:R:H158	R:R:P159	1.53	No	No	0	6	9
255	R:R:M85	R:R:V79	1.52	Yes	No	0	8	7
256	R:R:K221	R:R:V329	1.52	No	No	0	4	5
257	R:R:L74	R:R:V77	1.49	No	No	0	6	5
258	R:R:L133	R:R:T106	1.47	No	No	0	5	5
259	R:R:I178	R:R:I182	1.47	No	No	0	3	3
260	R:R:I362	R:R:I363	1.47	No	Yes	0	6	8
261	R:R:N90	R:R:T87	1.46	No	No	0	9	7
262	R:R:I225	R:R:M222	1.46	No	No	0	5	4
263	R:R:G123	R:R:W120	1.41	No	Yes	0	8	7
264	R:R:G215	R:R:W214	1.41	No	Yes	0	4	4
265	R:R:L244	R:R:M307	1.41	No	No	0	2	6
266	R:R:L150	R:R:L238	1.38	No	No	0	6	7
267	R:R:E217	R:R:I218	1.37	No	No	0	3	4
268	R:R:E292	R:R:I293	1.37	No	No	0	3	2
269	R:R:C226	R:R:Y223	1.34	No	Yes	0	4	8
270	R:R:A166	R:R:Y91	1.33	No	No	0	3	4
271	R:R:F371	R:R:S368	1.32	Yes	No	0	8	8
272	R:R:F65	R:R:V66	1.31	No	No	0	6	4
273	R:R:R168	R:R:T165	1.29	No	No	0	7	5
274	R:R:K294	R:R:R297	1.24	No	No	0	3	5
275	R:R:V56	R:R:W55	1.23	No	No	0	6	4
276	R:R:F330	R:R:L326	1.22	No	No	0	3	5
277	R:R:L250	R:R:R299	1.21	Yes	No	0	8	8
278	R:R:R86	R:R:W80	1	No	No	0	8	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y61	7.55167	6	1	7
2	R:R:L69	3.465	4	0	6
3	R:R:N82	3.5325	4	0	6
4	R:R:M85	3.826	5	0	8
5	R:R:F92	3.6925	4	0	8
6	R:R:D100	7.205	4	0	9
7	R:R:C107	5	4	0	7
8	R:R:L108	7.9325	4	1	7
9	R:R:D115	5.6025	4	1	5
10	R:R:W120	8.31667	6	3	7
11	R:R:I130	2.6675	4	0	5
12	R:R:W153	7.368	5	0	8
13	R:R:M184	5.355	4	0	7
14	R:R:Q187	4.81	4	2	6
15	R:R:E212	7.56	5	2	4
16	R:R:W214	9.95667	6	2	4
17	R:R:Y223	8.25	4	0	8
18	R:R:Y232	6.0575	4	0	8
19	R:R:Y243	6.16	4	0	9
20	R:R:L250	2.536	5	7	8
21	R:R:F313	5.62	4	4	9
22	R:R:F333	5.195	4	0	4
23	R:R:F346	6.665	4	0	4
24	R:R:H350	5.37	4	1	5
25	R:R:Y354	6.132	5	1	7
26	R:R:I363	3.4975	4	5	8
27	R:R:Y364	6.035	4	5	9
28	R:R:F371	4.425	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W351	R:R:Y61	10.2563	9.65	No	Yes	0	5	7
2	R:R:L112	R:R:Y61	15.2231	12.89	No	Yes	0	6	7
3	R:R:Y354	R:R:Y61	26.8306	4.96	Yes	Yes	1	7	7
4	R:R:F65	R:R:L108	13.5249	8.53	No	Yes	0	6	7
5	R:R:F65	R:R:L69	10.6032	3.65	No	Yes	0	6	6
6	R:R:C107	R:R:Y354	75.6224	4.03	Yes	Yes	0	7	7
7	R:R:C107	R:R:V103	100	5.12	Yes	No	0	7	7
8	R:R:S357	R:R:V103	99.6896	6.46	No	No	0	9	7
9	R:R:D100	R:R:S357	99.5618	5.89	Yes	No	0	9	9
10	R:R:D100	R:R:N72	43.8676	6.73	Yes	No	0	9	9
11	R:R:N72	R:R:S97	41.4815	8.94	No	No	0	9	9
12	R:R:S97	R:R:V75	37.7929	3.23	No	No	0	9	9
13	R:R:N365	R:R:V75	36.5451	5.91	No	No	0	7	9
14	R:R:F371	R:R:N365	31.5905	6.04	Yes	No	0	8	7
15	R:R:F371	R:R:M85	27.628	4.98	Yes	Yes	0	8	8
16	R:R:A78	R:R:M85	13.6344	1.61	No	Yes	0	8	8
17	R:R:A78	R:R:F375	12.1675	2.77	No	No	0	8	7
18	R:R:F375	R:R:L74	10.6884	2.44	No	No	0	7	6
19	R:R:D100	R:R:L96	78.3797	5.43	Yes	No	0	9	9
20	R:R:L145	R:R:L96	71.6842	5.54	No	No	0	9	9
21	R:R:L145	R:R:Y364	26.3132	8.21	No	Yes	0	9	9
22	R:R:I148	R:R:Y364	18.2178	6.04	No	Yes	0	8	9
23	R:R:F92	R:R:I148	17.5239	3.77	Yes	No	0	8	8
24	R:R:A169	R:R:F92	10.4328	2.77	No	Yes	0	7	8
25	R:R:L96	R:R:T144	13.3057	4.42	No	No	0	9	7
26	R:R:N95	R:R:T144	11.8753	5.85	No	No	0	9	7
27	R:R:D100	R:R:N360	10.8467	10.77	Yes	No	0	9	9
28	R:R:C107	R:R:Q134	47.3614	9.16	Yes	No	0	7	7
29	R:R:T111	R:R:Y354	30.7688	4.99	No	Yes	1	7	7
30	R:R:I116	R:R:L112	13.5796	2.85	No	No	0	5	6
31	R:R:I116	R:R:T117	11.924	3.04	No	No	0	5	5
32	R:R:E118	R:R:Y343	13.0805	4.49	No	No	0	4	3
33	L:L:I6	R:R:Y343	14.6631	4.84	No	No	0	0	3
34	L:L:I6	R:R:F346	16.0874	7.54	No	Yes	0	0	4
35	R:R:F346	R:R:H350	40.9885	5.66	Yes	Yes	0	4	5
36	R:R:E118	R:R:R339	11.4919	6.98	No	No	0	4	1
37	L:L:L7	R:R:Q134	13.3423	6.65	No	No	0	0	7
38	L:L:L7	R:R:W120	12.0214	3.42	No	Yes	0	0	7
39	R:R:I130	R:R:Q134	38.1886	4.12	Yes	No	0	5	7
40	R:R:I130	R:R:P131	35.4556	3.39	Yes	No	0	5	5
41	R:R:M191	R:R:P131	34.5913	5.03	No	No	0	6	5
42	R:R:M191	R:R:Q187	14.7483	4.08	No	Yes	2	6	6
43	R:R:Q187	R:R:T135	16.5135	7.09	Yes	No	0	6	6
44	R:R:M184	R:R:T135	15.1074	9.03	Yes	No	0	7	6
45	R:R:F313	R:R:L145	48.4387	3.65	Yes	No	0	9	9
46	R:R:P235	R:R:V142	12.7762	3.53	No	No	0	9	8
47	R:R:M239	R:R:Y243	28.5471	3.59	No	Yes	0	8	9
48	R:R:F313	R:R:M239	41.652	8.71	Yes	No	0	9	8
49	R:R:L306	R:R:Y243	27.7132	8.21	No	Yes	0	8	9
50	R:R:L306	R:R:T302	26.3984	2.95	No	No	0	8	8
51	R:R:L250	R:R:T302	25.2115	2.95	Yes	No	0	8	8
52	R:R:I246	R:R:L250	18.6804	2.85	No	Yes	7	9	8
53	R:R:C157	R:R:I246	17.3778	3.27	No	No	0	7	9
54	R:R:C157	R:R:W153	15.9839	7.84	No	Yes	0	7	8
55	R:R:F346	R:R:K327	29.5271	3.72	Yes	No	0	4	3
56	R:R:K327	R:R:R328	24.4507	18.56	No	No	0	3	4
57	R:R:H224	R:R:R328	14.5048	11.28	No	No	0	6	4
58	R:R:E212	R:R:M191	19.2282	4.06	Yes	No	2	4	6
59	R:R:E212	R:R:H224	13.6709	8.62	Yes	No	0	4	6
60	R:R:E212	R:R:W214	14.0666	14.17	Yes	Yes	2	4	4
61	L:L:G5	R:R:D211	12.971	5.03	No	No	0	0	5
62	R:R:D211	R:R:R328	14.4501	9.53	No	No	0	5	4
63	L:L:G5	R:R:V209	11.3762	3.68	No	No	0	0	5
64	R:R:V353	R:R:Y354	22.1499	3.79	No	Yes	0	7	7
65	R:R:I320	R:R:V353	21.3707	4.61	No	No	0	7	7
66	R:R:I320	R:R:S349	28.5593	3.1	No	No	0	7	6
67	R:R:P319	R:R:S349	27.1654	3.56	No	No	0	9	6
68	R:R:L318	R:R:P319	22.9107	4.93	No	No	0	6	9
69	R:R:L318	R:R:Y232	20.0134	4.69	No	Yes	0	6	8
70	R:R:F228	R:R:Y232	14.0727	7.22	No	Yes	0	6	8
71	R:R:L310	R:R:M239	17.39	2.83	No	No	0	8	8
72	R:R:L310	R:R:M307	14.5901	2.83	No	No	0	8	6
73	R:R:F247	R:R:M307	11.7414	6.22	No	No	0	6	6
74	R:R:H350	R:R:T111	28.3036	5.48	Yes	No	1	5	7
75	R:R:L108	R:R:Y354	14.8579	12.89	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C107	R:R:Q134	9.16	0	Yes	No	7	7	2	1
R:R:E118	R:R:R339	6.98	0	No	No	4	1	2	1
R:R:E118	R:R:Y343	4.49	0	No	No	4	3	2	1
R:R:F122	R:R:W120	15.03	0	No	Yes	6	7	2	1
R:R:C127	R:R:W120	7.84	3	No	Yes	9	7	2	1
R:R:C193	R:R:W120	3.92	3	No	Yes	4	7	2	1
R:R:C210	R:R:W120	18.28	3	No	Yes	9	7	2	1
L:L:L7	R:R:W120	3.42	0	No	Yes	0	7	0	1
R:R:C127	R:R:C193	3.64	3	No	No	9	4	2	2
R:R:C127	R:R:C210	7.28	3	No	No	9	9	2	2
R:R:I130	R:R:Q134	4.12	0	Yes	No	5	7	2	1
L:L:L7	R:R:Q134	6.65	0	No	No	0	7	0	1
R:R:M184	R:R:T135	9.03	0	Yes	No	7	6	2	2
R:R:Q187	R:R:T135	7.09	2	Yes	No	6	6	1	2
L:L:M9	R:R:V138	7.61	0	No	No	0	6	0	1
R:R:F227	R:R:M184	4.98	0	No	Yes	5	7	1	2
R:R:M191	R:R:Q187	4.08	2	No	Yes	6	6	2	1
R:R:E212	R:R:Q187	3.82	2	Yes	Yes	4	6	2	1
L:L:T8	R:R:Q187	4.25	0	No	Yes	0	6	0	1
R:R:E212	R:R:M191	4.06	2	Yes	No	4	6	2	2
L:L:G5	R:R:V209	3.68	0	No	No	0	5	0	1
R:R:D211	R:R:R328	9.53	0	No	No	5	4	1	2
L:L:G5	R:R:D211	5.03	0	No	No	0	5	0	1
R:R:F227	R:R:T231	7.78	0	No	No	5	6	1	2
L:L:M9	R:R:F227	3.73	0	No	No	0	5	0	1
R:R:F346	R:R:L323	9.74	0	Yes	No	4	5	1	2
L:L:T8	R:R:N324	8.77	0	No	No	0	7	0	1
R:R:K327	R:R:R328	18.56	0	No	No	3	4	2	2
R:R:F333	R:R:K327	3.72	0	Yes	No	4	3	1	2
R:R:F346	R:R:K327	3.72	0	Yes	No	4	3	1	2
R:R:F333	R:R:V342	11.8	0	Yes	No	4	5	1	2
R:R:A334	R:R:H335	4.39	0	No	No	2	1	1	2
R:R:D338	R:R:T336	4.34	0	No	No	3	4	2	1
L:L:H2	R:R:T336	6.85	0	No	No	0	4	0	1
L:L:H2	R:R:R339	18.05	0	No	No	0	1	0	1
L:L:I6	R:R:Y343	4.84	0	No	No	0	3	0	1
R:R:F346	R:R:H350	5.66	0	Yes	Yes	4	5	1	2
L:L:I6	R:R:F346	7.54	0	No	Yes	0	4	0	1
L:L:A3	R:R:F333	2.77	0	No	Yes	0	4	0	1
R:R:F333	R:R:M332	2.49	0	Yes	No	4	3	1	2
L:L:A4	R:R:V209	1.7	0	No	No	0	5	0	1
R:R:S194	R:R:V209	1.62	0	No	No	3	5	2	1
L:L:N1	R:R:A334	1.56	0	No	No	0	2	0	1
R:R:G123	R:R:W120	1.41	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7L1U_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	271
Number of Links	278
Number of Hubs	28
Number of Links mediated by Hubs	111
Number of Communities	7
Number of Nodes involved in Communities	29
Number of Links involved in Communities	34

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	32807
Length Of Smallest Path	3
Average Path Length	14.1432
Length of Longest Path	31
Minimum Path Strength	1.425
Average Path Strength	5.70803
Maximum Path Strength	19.92
Minimum Path Correlation	0.7
Average Path Correlation	0.930211
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	52.035
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.8673
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43614
Sequence	>7L1U_nogp_Chain_R H P K E Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N H H M R T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E T W F F G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H P L M F K S T A K R A R N S I V I I W I V S C I I M I P Q A I V M E C S T V F F T V C D E R W G G E I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W E I K Q I R A R R K T A R M L M V V L L V F A I C Y L P I S I L N V L K R V F G M F A H T E D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F R E E F K A A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XRR	A	Peptide	Orexin	OX₂	Homo sapiens	Lemborexant	-	-	2.89	2022-11-23	10.1016/j.str.2022.11.001
	7SR8	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.3	2022-06-08	10.1038/s41467-022-30601-3
	7SR8 (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.3	2022-06-08	10.1038/s41467-022-30601-3
	7SQO	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	Gi1/β1/γ2	3.17	2022-05-25	10.1038/s41467-022-30601-3
	7SQO (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.17	2022-05-25	10.1038/s41467-022-30601-3
	7L1V	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2021-02-10	10.1038/s41467-021-21087-6
	7L1V (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-		3	2021-02-10	10.1038/s41467-021-21087-6
	7L1U	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-02-10	10.1038/s41467-021-21087-6
	7L1U (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-		3.2	2021-02-10	10.1038/s41467-021-21087-6
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	5WS3	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.3	2017-12-13	10.1016/j.str.2017.11.005
	5WQC	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	1.96	2017-11-29	10.1016/j.str.2017.11.005
	4S0V	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.5	2015-01-14	10.1038/nature14035

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7L1U_nogp.zip

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