psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L57	R:R:W55	6.83	No	No	0	5	4
2	R:R:I58	R:R:W55	3.52	Yes	No	0	5	4
3	R:R:I58	R:R:L112	4.28	Yes	No	0	5	6
4	R:R:L108	R:R:Y61	7.03	Yes	Yes	1	7	7
5	R:R:T111	R:R:Y61	4.99	No	Yes	1	7	7
6	R:R:L112	R:R:Y61	14.07	No	Yes	0	6	7
7	R:R:T347	R:R:Y61	4.99	No	Yes	0	4	7
8	R:R:W351	R:R:Y61	5.79	No	Yes	0	5	7
9	R:R:Y354	R:R:Y61	6.95	Yes	Yes	1	7	7
10	R:R:V64	R:R:W351	8.58	No	No	0	7	5
11	R:R:F65	R:R:L69	4.87	No	No	0	6	6
12	R:R:F65	R:R:L108	8.53	No	Yes	0	6	7
13	R:R:A68	R:R:T104	5.03	No	No	0	8	7
14	R:R:N72	R:R:S97	5.96	Yes	No	0	9	9
15	R:R:D100	R:R:N72	6.73	Yes	Yes	0	9	9
16	R:R:N72	R:R:P361	9.77	Yes	No	0	9	9
17	R:R:S97	R:R:V75	3.23	No	No	0	9	9
18	R:R:N365	R:R:V75	8.87	No	No	0	7	9
19	R:R:V79	R:R:V94	4.81	No	No	0	7	6
20	R:R:K81	R:R:W80	6.96	No	No	0	6	3
21	R:R:H84	R:R:N82	6.38	No	Yes	0	5	6
22	R:R:M85	R:R:N82	8.41	Yes	Yes	0	8	6
23	R:R:H83	R:R:R86	5.64	No	No	0	7	8
24	R:R:F371	R:R:M85	3.73	Yes	Yes	0	8	8
25	R:R:E374	R:R:M85	5.41	No	Yes	0	7	8
26	R:R:N90	R:R:T87	4.39	No	No	0	9	7
27	R:R:S164	R:R:V88	3.23	No	No	0	5	6
28	R:R:A166	R:R:V88	3.39	No	No	0	3	6
29	R:R:A169	R:R:Y91	4	No	No	0	7	4
30	R:R:F92	R:R:T144	3.89	Yes	No	0	8	7
31	R:R:C147	R:R:F92	5.59	No	Yes	0	6	8
32	R:R:F92	R:R:I148	3.77	Yes	No	0	8	8
33	R:R:F92	R:R:S172	3.96	Yes	No	0	8	6
34	R:R:I93	R:R:N365	5.66	No	No	0	8	7
35	R:R:N95	R:R:T144	5.85	No	No	0	9	7
36	R:R:I173	R:R:N95	12.74	No	No	0	8	9
37	R:R:N95	R:R:W177	7.91	No	No	0	9	9
38	R:R:D100	R:R:L96	9.5	Yes	Yes	2	9	9
39	R:R:L96	R:R:T144	4.42	Yes	No	0	9	7
40	R:R:L145	R:R:L96	5.54	No	Yes	0	9	9
41	R:R:L96	R:R:N360	8.24	Yes	Yes	2	9	9
42	R:R:A99	R:R:V140	3.39	No	Yes	0	8	7
43	R:R:D100	R:R:S141	5.89	Yes	No	0	9	9
44	R:R:D100	R:R:S357	7.36	Yes	No	0	9	9
45	R:R:D100	R:R:N360	8.08	Yes	Yes	2	9	9
46	R:R:L102	R:R:S137	6.01	No	No	0	6	5
47	R:R:S357	R:R:V103	6.46	No	No	0	9	7
48	R:R:C107	R:R:Q134	6.1	No	Yes	1	7	7
49	R:R:C107	R:R:Y354	6.72	No	Yes	1	7	7
50	L:L:?1	R:R:C107	4.08	Yes	No	1	0	7
51	R:R:L108	R:R:Y354	8.21	Yes	Yes	1	7	7
52	R:R:T111	R:R:Y354	9.99	No	Yes	1	7	7
53	L:L:?1	R:R:T111	11.36	Yes	No	1	0	7
54	L:L:?1	R:R:V114	10.53	Yes	No	0	0	5
55	R:R:D115	R:R:T347	11.56	No	No	0	5	4
56	R:R:F121	R:R:T117	3.89	No	No	0	4	5
57	R:R:E118	R:R:Y343	6.73	No	No	0	4	3
58	R:R:F121	R:R:T119	3.89	No	No	0	4	5
59	R:R:F122	R:R:W120	13.03	No	Yes	0	6	7
60	R:R:C127	R:R:W120	3.92	No	Yes	1	9	7
61	R:R:I130	R:R:W120	3.52	Yes	Yes	0	5	7
62	R:R:C210	R:R:W120	16.98	No	Yes	1	9	7
63	L:L:?1	R:R:W120	3.66	Yes	Yes	1	0	7
64	R:R:F121	R:R:F122	4.29	No	No	0	4	6
65	R:R:F122	R:R:L126	4.87	No	No	0	6	5
66	R:R:K128	R:R:Q124	4.07	No	No	3	6	4
67	R:R:E192	R:R:Q124	8.92	Yes	No	3	5	4
68	R:R:I130	R:R:L126	8.56	Yes	No	0	5	5
69	R:R:C127	R:R:C210	7.28	No	No	1	9	9
70	R:R:E192	R:R:K128	5.4	Yes	No	3	5	6
71	R:R:I130	R:R:P131	3.39	Yes	No	0	5	5
72	R:R:I130	R:R:Q134	5.49	Yes	Yes	0	5	7
73	R:R:M191	R:R:P131	5.03	Yes	No	1	6	5
74	L:L:?1	R:R:P131	7.39	Yes	No	1	0	5
75	R:R:V136	R:R:Y132	6.31	No	No	0	5	6
76	R:R:I185	R:R:Y132	3.63	No	No	0	5	6
77	R:R:A188	R:R:Y132	4	No	No	0	6	6
78	L:L:?1	R:R:Q134	15.39	Yes	Yes	1	0	7
79	R:R:M184	R:R:T135	9.03	Yes	No	0	7	6
80	R:R:Q187	R:R:T135	8.5	No	No	0	6	6
81	L:L:?1	R:R:T135	4.74	Yes	No	0	0	6
82	R:R:C181	R:R:V136	3.42	No	No	0	4	5
83	L:L:?1	R:R:V138	6.7	Yes	No	0	0	6
84	R:R:S139	R:R:S180	4.89	No	No	0	7	8
85	R:R:M184	R:R:S139	4.6	Yes	No	0	7	7
86	R:R:I176	R:R:V140	4.61	No	Yes	0	6	7
87	R:R:V140	R:R:W177	12.26	Yes	No	0	7	9
88	R:R:S180	R:R:V140	3.23	No	Yes	0	8	7
89	R:R:P235	R:R:V142	3.53	No	No	0	9	8
90	R:R:F313	R:R:V142	3.93	Yes	No	2	9	8
91	R:R:V142	R:R:Y317	5.05	No	Yes	2	8	7
92	R:R:L145	R:R:Y364	4.69	No	Yes	0	9	9
93	R:R:P235	R:R:S146	3.56	No	No	0	9	7
94	R:R:C147	R:R:I176	4.91	No	No	0	6	6
95	R:R:I148	R:R:R152	6.26	No	No	2	8	9
96	R:R:I148	R:R:Y364	3.63	No	Yes	2	8	9
97	R:R:A149	R:R:Y243	4	No	Yes	0	8	9
98	R:R:L150	R:R:L238	4.15	No	No	0	6	7
99	R:R:D151	R:R:S164	5.89	No	No	0	9	5
100	R:R:R152	R:R:Y243	8.23	No	Yes	2	9	9
101	R:R:R152	R:R:Y364	6.17	No	Yes	2	9	9
102	R:R:W153	R:R:Y154	3.86	Yes	No	0	8	4
103	R:R:C157	R:R:W153	6.53	No	Yes	0	7	8
104	R:R:H158	R:R:W153	8.46	No	Yes	0	6	8
105	R:R:A242	R:R:W153	3.89	No	Yes	0	5	8
106	R:R:Q245	R:R:W153	10.95	No	Yes	0	5	8
107	R:R:K163	R:R:Y154	15.53	No	No	4	5	4
108	R:R:R168	R:R:Y154	7.2	No	No	4	7	4
109	R:R:I156	R:R:I246	7.36	No	No	0	8	9
110	R:R:H158	R:R:M161	5.25	No	No	0	6	5
111	R:R:L160	R:R:P159	3.28	No	No	0	7	9
112	R:R:K163	R:R:R168	12.38	No	No	4	5	7
113	R:R:K167	R:R:T165	10.51	No	No	0	5	5
114	R:R:N171	R:R:R170	13.26	No	No	0	3	4
115	R:R:I183	R:R:M184	4.37	No	Yes	0	5	7
116	R:R:F227	R:R:M184	4.98	No	Yes	0	5	7
117	R:R:I185	R:R:P186	3.39	No	No	0	5	6
118	R:R:P186	R:R:Y223	13.91	No	No	0	6	8
119	R:R:E212	R:R:Q187	3.82	Yes	No	0	4	6
120	R:R:Q187	R:R:Y223	4.51	No	No	0	6	8
121	R:R:V190	R:R:W214	20.84	No	Yes	0	6	4
122	R:R:C210	R:R:M191	3.24	No	Yes	1	9	6
123	R:R:E212	R:R:M191	4.06	Yes	Yes	1	4	6
124	L:L:?1	R:R:M191	3.63	Yes	Yes	1	0	6
125	R:R:E192	R:R:R213	5.82	Yes	No	0	5	4
126	R:R:L206	R:R:T195	4.42	No	No	0	4	2
127	R:R:F207	R:R:V196	9.18	No	No	0	3	3
128	R:R:V196	R:R:V209	4.81	No	No	0	3	5
129	R:R:R339	R:R:V196	5.23	No	No	0	1	3
130	R:R:F197	R:R:P198	4.33	No	No	0	2	2
131	R:R:F197	R:R:G199	6.02	No	No	0	2	5
132	R:R:F197	R:R:L206	3.65	No	No	0	2	4
133	R:R:K203	R:R:P198	16.73	No	No	0	3	2
134	R:R:K203	R:R:L200	5.64	No	No	0	3	3
135	R:R:D211	R:R:R328	8.34	No	Yes	0	5	4
136	R:R:E212	R:R:W214	14.17	Yes	Yes	0	4	4
137	R:R:E212	R:R:H224	9.85	Yes	No	1	4	6
138	R:R:E212	R:R:R328	17.45	Yes	Yes	1	4	4
139	R:R:P220	R:R:W214	22.97	No	Yes	0	5	4
140	R:R:H224	R:R:Y223	7.62	No	No	0	6	8
141	R:R:H224	R:R:R328	18.05	No	Yes	1	6	4
142	R:R:F227	R:R:T231	3.89	No	No	0	5	6
143	L:L:?1	R:R:F227	4.7	Yes	No	0	0	5
144	R:R:F228	R:R:Y232	6.19	No	Yes	0	6	8
145	R:R:L236	R:R:Y232	4.69	Yes	Yes	0	6	8
146	R:R:L318	R:R:Y232	7.03	No	Yes	0	6	8
147	R:R:S321	R:R:Y232	8.9	No	Yes	0	6	8
148	R:R:C237	R:R:M233	3.24	No	No	0	4	5
149	R:R:F313	R:R:L236	3.65	Yes	Yes	0	9	6
150	R:R:M239	R:R:Y243	3.59	No	Yes	2	8	9
151	R:R:L310	R:R:M239	4.24	Yes	No	2	8	8
152	R:R:F313	R:R:M239	9.95	Yes	No	2	9	8
153	R:R:L306	R:R:Y243	7.03	No	Yes	0	8	9
154	R:R:L310	R:R:Y243	3.52	Yes	Yes	2	8	9
155	R:R:F247	R:R:W251	16.04	No	No	0	6	5
156	R:R:F247	R:R:M307	7.46	No	No	0	6	6
157	R:R:L250	R:R:R299	3.64	No	No	0	8	8
158	R:R:L250	R:R:T302	4.42	No	No	0	8	8
159	R:R:R300	R:R:W251	23.99	No	No	0	5	5
160	R:R:I296	R:R:R300	3.76	No	No	0	4	5
161	R:R:K301	R:R:R304	8.66	No	No	0	8	8
162	R:R:K301	R:R:M305	5.76	No	No	0	8	8
163	R:R:I363	R:R:V309	6.14	Yes	No	2	8	8
164	R:R:V309	R:R:Y364	5.05	No	Yes	2	8	9
165	R:R:F313	R:R:Y317	7.22	Yes	Yes	2	9	7
166	R:R:V353	R:R:Y317	7.57	No	Yes	0	7	7
167	R:R:N356	R:R:Y317	8.14	No	Yes	0	9	7
168	R:R:L318	R:R:P319	3.28	No	No	0	6	9
169	R:R:P319	R:R:S349	3.56	No	No	0	9	6
170	R:R:L352	R:R:P319	3.28	No	No	0	8	9
171	R:R:H350	R:R:I320	10.61	No	No	1	5	7
172	L:L:?1	R:R:I320	6.42	Yes	No	1	0	7
173	R:R:F346	R:R:L323	4.87	No	No	0	4	5
174	R:R:N324	R:R:R328	3.62	No	Yes	0	7	4
175	L:L:?1	R:R:N324	7.06	Yes	No	0	0	7
176	R:R:K327	R:R:R328	4.95	No	Yes	0	3	4
177	R:R:F346	R:R:K327	4.96	No	No	0	4	3
178	R:R:F330	R:R:V329	3.93	No	Yes	0	3	5
179	R:R:F333	R:R:M332	7.46	No	No	0	4	3
180	R:R:F333	R:R:V342	5.24	No	No	0	4	5
181	R:R:F333	R:R:F346	5.36	No	No	0	4	4
182	R:R:D338	R:R:E340	3.9	No	No	0	3	1
183	R:R:D338	R:R:T341	8.67	No	No	0	3	4
184	R:R:R339	R:R:Y343	18.52	No	No	0	1	3
185	L:L:?1	R:R:Y343	18.83	Yes	No	0	0	3
186	R:R:F348	R:R:L352	3.65	No	No	0	4	8
187	R:R:H350	R:R:Y354	7.62	No	Yes	1	5	7
188	L:L:?1	R:R:H350	17.35	Yes	No	1	0	5
189	R:R:V353	R:R:Y354	3.79	No	Yes	0	7	7
190	R:R:N356	R:R:N360	10.9	No	Yes	0	9	9
191	R:R:N360	R:R:Y364	5.81	Yes	Yes	2	9	9
192	R:R:I363	R:R:Y364	6.04	Yes	Yes	2	8	9
193	R:R:F371	R:R:N365	14.5	Yes	No	0	8	7
194	R:R:F366	R:R:F371	5.36	No	Yes	0	5	8
195	R:R:F366	R:R:F375	5.36	No	No	0	5	7
196	R:R:G369	R:R:R372	4.5	No	No	0	5	8
197	R:R:E374	R:R:K370	9.45	No	No	0	7	7
198	R:R:E373	R:R:K376	4.05	No	No	0	5	5
199	R:R:V325	R:R:V329	3.21	No	Yes	0	6	5
200	R:R:S137	R:R:T106	3.2	No	No	0	5	5
201	R:R:C316	R:R:N356	3.15	No	No	0	8	9
202	R:R:T87	R:R:T89	3.14	No	No	0	7	8
203	R:R:I189	R:R:V190	3.07	No	No	0	5	6
204	R:R:I225	R:R:V329	3.07	No	Yes	0	5	5
205	R:R:I363	R:R:V312	3.07	Yes	No	0	8	6
206	R:R:K221	R:R:V329	3.04	No	Yes	0	4	5
207	R:R:F348	R:R:W345	3.01	No	No	0	4	5
208	R:R:L238	R:R:S146	3	No	No	0	7	7
209	R:R:K203	R:R:T205	3	No	No	0	3	3
210	R:R:L126	R:R:V129	2.98	No	No	0	5	4
211	R:R:L236	R:R:V240	2.98	Yes	No	0	6	5
212	R:R:L310	R:R:V240	2.98	Yes	No	0	8	5
213	R:R:N72	R:R:V101	2.96	Yes	No	0	9	7
214	R:R:L69	R:R:T104	2.95	No	No	0	6	7
215	R:R:I116	R:R:I58	2.94	No	Yes	0	5	5
216	R:R:I156	R:R:K249	2.91	No	No	0	8	5
217	R:R:I218	R:R:K221	2.91	No	No	0	4	4
218	R:R:F207	R:R:P198	2.89	No	No	0	3	2
219	R:R:I176	R:R:L143	2.85	No	No	0	6	6
220	R:R:I93	R:R:N90	2.83	No	No	0	8	9
221	R:R:Q134	R:R:T106	2.83	Yes	No	0	7	5
222	R:R:L229	R:R:M233	2.83	No	No	0	4	5
223	R:R:L310	R:R:M307	2.83	Yes	No	0	8	6
224	R:R:L326	R:R:M332	2.83	No	No	0	5	3
225	R:R:A78	R:R:F375	2.77	No	No	0	8	7
226	R:R:A169	R:R:F92	2.77	No	Yes	0	7	8
227	R:R:A303	R:R:F247	2.77	No	No	0	7	6
228	R:R:F228	R:R:M233	2.49	No	No	0	6	5
229	R:R:V56	R:R:W55	2.45	No	No	0	6	4
230	R:R:F330	R:R:L326	2.44	No	No	0	3	5
231	R:R:T341	R:R:W345	2.43	No	No	0	4	5
232	R:R:I218	R:R:Y219	2.42	No	No	0	4	3
233	R:R:I246	R:R:Y243	2.42	No	Yes	0	9	9
234	R:R:I246	R:R:W153	2.35	No	Yes	0	9	8
235	R:R:G215	R:R:G216	2.11	No	No	0	4	5
236	R:R:R86	R:R:W80	2	No	No	0	8	3
237	R:R:A59	R:R:G60	1.95	No	No	0	4	4
238	R:R:A234	R:R:P235	1.87	No	No	0	5	9
239	R:R:C127	R:R:C193	1.82	No	No	0	9	4
240	R:R:A358	R:R:A68	1.79	No	No	0	5	8
241	R:R:G71	R:R:I70	1.76	No	No	0	8	4
242	R:R:C76	R:R:S97	1.72	No	No	0	6	9
243	R:R:A169	R:R:V88	1.7	No	No	0	7	6
244	R:R:C193	R:R:T208	1.69	No	No	0	4	3
245	R:R:L108	R:R:P109	1.64	Yes	No	0	7	8
246	R:R:E217	R:R:G216	1.64	No	No	0	3	5
247	R:R:S194	R:R:V209	1.62	No	No	0	3	5
248	R:R:A378	R:R:K81	1.61	No	No	0	6	6
249	R:R:V66	R:R:V67	1.6	No	No	0	4	5
250	R:R:V101	R:R:V73	1.6	No	No	0	7	4
251	R:R:C76	R:R:L98	1.59	No	No	0	6	5
252	R:R:T117	R:R:V113	1.59	No	No	0	5	4
253	R:R:A314	R:R:L236	1.58	No	Yes	0	5	6
254	R:R:A303	R:R:L250	1.58	No	No	0	7	8
255	R:R:A377	R:R:N82	1.56	No	Yes	0	4	6
256	R:R:A378	R:R:N82	1.56	No	Yes	0	6	6
257	R:R:I175	R:R:V179	1.54	No	No	0	3	5
258	R:R:H158	R:R:P159	1.53	No	No	0	6	9
259	R:R:M85	R:R:V79	1.52	Yes	No	0	8	7
260	R:R:I105	R:R:T106	1.52	No	No	0	4	5
261	R:R:A110	R:R:Q134	1.52	No	Yes	0	4	7
262	R:R:L74	R:R:V73	1.49	No	No	0	6	4
263	R:R:L133	R:R:V129	1.49	No	No	0	5	4
264	R:R:L143	R:R:V179	1.49	No	No	0	6	5
265	R:R:I58	R:R:I62	1.47	Yes	No	0	5	3
266	R:R:I178	R:R:I182	1.47	No	No	0	3	3
267	R:R:L200	R:R:T336	1.47	No	No	0	3	4
268	R:R:E192	R:R:S194	1.44	Yes	No	0	5	3
269	R:R:I322	R:R:L318	1.43	No	No	0	5	6
270	R:R:I362	R:R:L367	1.43	No	No	0	6	7
271	R:R:I363	R:R:L367	1.43	Yes	No	0	8	7
272	R:R:G60	R:R:W351	1.41	No	No	0	4	5
273	R:R:G123	R:R:W120	1.41	No	Yes	0	8	7
274	R:R:G215	R:R:W214	1.41	No	Yes	0	4	4
275	R:R:L244	R:R:M307	1.41	No	No	0	2	6
276	R:R:E292	R:R:I296	1.37	No	No	0	3	4
277	R:R:F371	R:R:S368	1.32	Yes	No	0	8	8
278	R:R:F65	R:R:V66	1.31	No	No	0	6	4
279	R:R:R168	R:R:T165	1.29	No	No	0	7	5
280	R:R:E292	R:R:Q295	1.27	No	No	0	3	4
281	R:R:F375	R:R:K376	1.24	No	No	0	7	5
282	R:R:L244	R:R:R248	1.21	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I58	3.0525	4	0	5
2	R:R:Y61	7.30333	6	1	7
3	R:R:N72	6.355	4	0	9
4	R:R:N82	4.4775	4	0	6
5	R:R:M85	4.7675	4	0	8
6	R:R:F92	3.996	5	0	8
7	R:R:L96	6.925	4	2	9
8	R:R:D100	7.512	5	2	9
9	R:R:L108	6.3525	4	1	7
10	R:R:W120	7.08667	6	1	7
11	R:R:I130	5.24	4	0	5
12	R:R:Q134	6.266	5	1	7
13	R:R:V140	5.8725	4	0	7
14	R:R:W153	6.00667	6	0	8
15	R:R:M184	5.745	4	0	7
16	R:R:M191	3.99	4	1	6
17	R:R:E192	5.395	4	3	5
18	R:R:E212	9.87	5	1	4
19	R:R:W214	14.8475	4	0	4
20	R:R:Y232	6.7025	4	0	8
21	R:R:L236	3.225	4	0	6
22	R:R:Y243	4.79833	6	2	9
23	R:R:L310	3.3925	4	2	8
24	R:R:F313	6.1875	4	2	9
25	R:R:Y317	6.995	4	2	7
26	R:R:R328	10.482	5	1	4
27	R:R:V329	3.3125	4	0	5
28	R:R:Y354	7.21333	6	1	7
29	R:R:N360	8.2575	4	2	9
30	R:R:I363	4.17	4	2	8
31	R:R:Y364	5.23167	6	2	9
32	R:R:F371	6.2275	4	0	8
33	L:L:?1	8.70286	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F65	R:R:L108	12.2225	8.53	No	Yes	0	6	7
2	R:R:V353	R:R:Y354	100	3.79	No	Yes	0	7	7
3	R:R:V353	R:R:Y317	99.5203	7.57	No	Yes	0	7	7
4	R:R:N356	R:R:Y317	51.342	8.14	No	Yes	0	9	7
5	R:R:N356	R:R:N360	49.8369	10.9	No	Yes	0	9	9
6	R:R:D100	R:R:N360	40.1543	8.08	Yes	Yes	2	9	9
7	R:R:D100	R:R:N72	39.0066	6.73	Yes	Yes	0	9	9
8	R:R:N72	R:R:S97	33.7075	5.96	Yes	No	0	9	9
9	R:R:S97	R:R:V75	30.4434	3.23	No	No	0	9	9
10	R:R:N365	R:R:V75	29.3459	8.87	No	No	0	7	9
11	R:R:F371	R:R:N365	23.8869	14.5	Yes	No	0	8	7
12	R:R:F371	R:R:M85	15.8096	3.73	Yes	Yes	0	8	8
13	R:R:N360	R:R:Y364	14.7341	5.81	Yes	Yes	2	9	9
14	R:R:I176	R:R:V140	10.6484	4.61	No	Yes	0	6	7
15	R:R:S180	R:R:V140	15.3236	3.23	No	Yes	0	8	7
16	R:R:S139	R:R:S180	16.258	4.89	No	No	0	7	8
17	R:R:M184	R:R:S139	17.4589	4.6	Yes	No	0	7	7
18	R:R:M184	R:R:T135	11.9183	9.03	Yes	No	0	7	6
19	L:L:?1	R:R:T135	21.9115	4.74	Yes	No	0	0	6
20	L:L:?1	R:R:T111	39.5021	11.36	Yes	No	1	0	7
21	L:L:?1	R:R:F227	12.1692	4.7	Yes	No	0	0	5
22	R:R:C107	R:R:Y354	36.3822	6.72	No	Yes	1	7	7
23	L:L:?1	R:R:W120	19.9987	3.66	Yes	Yes	1	0	7
24	L:L:?1	R:R:Y343	32.7261	18.83	Yes	No	0	0	3
25	L:L:?1	R:R:M191	15.2295	3.63	Yes	Yes	1	0	6
26	R:R:V196	R:R:V209	10.175	4.81	No	No	0	3	5
27	R:R:R339	R:R:V196	28.2014	5.23	No	No	0	1	3
28	R:R:R339	R:R:Y343	29.81	18.52	No	No	0	1	3
29	R:R:Q187	R:R:T135	13.9345	8.5	No	No	0	6	6
30	R:R:Q187	R:R:Y223	11.0373	4.51	No	No	0	6	8
31	R:R:P186	R:R:Y223	10.1812	13.91	No	No	0	6	8
32	R:R:F313	R:R:Y317	51.6054	7.22	Yes	Yes	2	9	7
33	R:R:F313	R:R:M239	33.6197	9.95	Yes	No	2	9	8
34	R:R:M239	R:R:Y243	20.6259	3.59	No	Yes	2	8	9
35	R:R:R152	R:R:Y243	11.8556	8.23	No	Yes	2	9	9
36	R:R:I246	R:R:Y243	20.582	2.42	No	Yes	0	9	9
37	R:R:I246	R:R:W153	16.9259	2.35	No	Yes	0	9	8
38	R:R:E212	R:R:M191	13.737	4.06	Yes	Yes	1	4	6
39	R:R:E212	R:R:W214	11.3226	14.17	Yes	Yes	0	4	4
40	R:R:F207	R:R:P198	15.1731	2.89	No	No	0	3	2
41	R:R:F207	R:R:V196	16.8318	9.18	No	No	0	3	3
42	R:R:N324	R:R:R328	26.8061	3.62	No	Yes	0	7	4
43	L:L:?1	R:R:N324	28.1795	7.06	Yes	No	0	0	7
44	R:R:L236	R:R:Y232	23.0246	4.69	Yes	Yes	0	6	8
45	R:R:F313	R:R:L236	23.5012	3.65	Yes	Yes	0	9	6
46	R:R:L318	R:R:Y232	14.5773	7.03	No	Yes	0	6	8
47	R:R:L310	R:R:M239	12.2225	4.24	Yes	No	2	8	8
48	R:R:F247	R:R:M307	12.1284	7.46	No	No	0	6	6
49	R:R:L310	R:R:M307	15.772	2.83	Yes	No	0	8	6
50	R:R:L318	R:R:P319	11.7114	3.28	No	No	0	6	9
51	R:R:H350	R:R:Y354	32.0457	7.62	No	Yes	1	5	7
52	R:R:F346	R:R:K327	22.8741	4.96	No	No	0	4	3
53	R:R:K327	R:R:R328	24.6049	4.95	No	Yes	0	3	4
54	R:R:F330	R:R:L326	12.5078	2.44	No	No	0	3	5
55	R:R:L326	R:R:M332	14.27	2.83	No	No	0	5	3
56	R:R:F333	R:R:M332	16.026	7.46	No	No	0	4	3
57	R:R:F333	R:R:F346	19.5096	5.36	No	No	0	4	4
58	R:R:F330	R:R:V329	10.7394	3.93	No	Yes	0	3	5
59	R:R:L108	R:R:Y354	12.4984	8.21	Yes	Yes	1	7	7
60	R:R:T111	R:R:Y354	31.4812	9.99	No	Yes	1	7	7
61	L:L:?1	R:R:C107	31.3558	4.08	Yes	No	1	0	7
62	L:L:?1	R:R:H350	31.4499	17.35	Yes	No	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T111	R:R:Y61	4.99	1	No	Yes	7	7	1	2
R:R:Y354	R:R:Y61	6.95	1	Yes	Yes	7	7	2	2
R:R:C107	R:R:Q134	6.1	1	No	Yes	7	7	1	1
R:R:C107	R:R:Y354	6.72	1	No	Yes	7	7	1	2
L:L:?1	R:R:C107	4.08	1	Yes	No	0	7	0	1
R:R:T111	R:R:Y354	9.99	1	No	Yes	7	7	1	2
L:L:?1	R:R:T111	11.36	1	Yes	No	0	7	0	1
L:L:?1	R:R:V114	10.53	1	Yes	No	0	5	0	1
R:R:E118	R:R:Y343	6.73	0	No	No	4	3	2	1
R:R:F122	R:R:W120	13.03	0	No	Yes	6	7	2	1
R:R:C127	R:R:W120	3.92	1	No	Yes	9	7	2	1
R:R:I130	R:R:W120	3.52	0	Yes	Yes	5	7	2	1
R:R:C210	R:R:W120	16.98	1	No	Yes	9	7	2	1
L:L:?1	R:R:W120	3.66	1	Yes	Yes	0	7	0	1
R:R:C127	R:R:C210	7.28	1	No	No	9	9	2	2
R:R:I130	R:R:P131	3.39	0	Yes	No	5	5	2	1
R:R:I130	R:R:Q134	5.49	0	Yes	Yes	5	7	2	1
R:R:M191	R:R:P131	5.03	1	Yes	No	6	5	1	1
L:L:?1	R:R:P131	7.39	1	Yes	No	0	5	0	1
L:L:?1	R:R:Q134	15.39	1	Yes	Yes	0	7	0	1
R:R:M184	R:R:T135	9.03	0	Yes	No	7	6	2	1
R:R:Q187	R:R:T135	8.5	0	No	No	6	6	2	1
L:L:?1	R:R:T135	4.74	1	Yes	No	0	6	0	1
L:L:?1	R:R:V138	6.7	1	Yes	No	0	6	0	1
R:R:F227	R:R:M184	4.98	0	No	Yes	5	7	1	2
R:R:E212	R:R:Q187	3.82	1	Yes	No	4	6	2	2
R:R:C210	R:R:M191	3.24	1	No	Yes	9	6	2	1
R:R:E212	R:R:M191	4.06	1	Yes	Yes	4	6	2	1
L:L:?1	R:R:M191	3.63	1	Yes	Yes	0	6	0	1
R:R:E212	R:R:R328	17.45	1	Yes	Yes	4	4	2	2
R:R:F227	R:R:T231	3.89	0	No	No	5	6	1	2
L:L:?1	R:R:F227	4.7	1	Yes	No	0	5	0	1
R:R:H350	R:R:I320	10.61	1	No	No	5	7	1	1
L:L:?1	R:R:I320	6.42	1	Yes	No	0	7	0	1
R:R:N324	R:R:R328	3.62	0	No	Yes	7	4	1	2
L:L:?1	R:R:N324	7.06	1	Yes	No	0	7	0	1
R:R:R339	R:R:Y343	18.52	0	No	No	1	3	2	1
L:L:?1	R:R:Y343	18.83	1	Yes	No	0	3	0	1
R:R:H350	R:R:Y354	7.62	1	No	Yes	5	7	1	2
L:L:?1	R:R:H350	17.35	1	Yes	No	0	5	0	1
R:R:Q134	R:R:T106	2.83	1	Yes	No	7	5	1	2
R:R:A110	R:R:Q134	1.52	0	No	Yes	4	7	2	1
R:R:G123	R:R:W120	1.41	0	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7L1V_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	258
Number of Links	282
Number of Hubs	33
Number of Links mediated by Hubs	136
Number of Communities	4
Number of Nodes involved in Communities	37
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	57485
Length Of Smallest Path	3
Average Path Length	13.1056
Length of Longest Path	32
Minimum Path Strength	1.31
Average Path Strength	6.56674
Maximum Path Strength	21.905
Minimum Path Correlation	0.7
Average Path Correlation	0.928164
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	52.3547
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.9309
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XGD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	XGD
Name	4'-methoxy-N,N-dimethyl-3'-{[3-(2-{[2-(2H-1,2,3-triazol-2-yl)benzene-1-carbonyl]amino}ethyl)phenyl]sulfamoyl}[1,1'-biphenyl]-3-carboxamide
Synonyms
Identifier
Formula	C33 H32 N6 O5 S
Molecular Weight	624.709
SMILES
PubChem	155491009
Formal Charge	0
Total Atoms	77
Total Chiral Atoms	0
Total Bonds	81
Total Aromatic Bonds	29


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43614
Sequence	>7L1V_nogp_Chain_R W V L I A G Y I I V F V V A L I G N V L V C V A V W K N H H M R T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E T W F F G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H P L M F K S T A K R A R N S I V I I W I V S C I I M I P Q A I V M E C S T V F P G L A N K T T L F T V C D E R W G G E I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W E I K Q I R A R R K T A R M L M V V L L V F A I C Y L P I S I L N V L K R V F G M F A H T E D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F R E E F K A A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XRR	A	Peptide	Orexin	OX₂	Homo sapiens	Lemborexant	-	-	2.89	2022-11-23	10.1016/j.str.2022.11.001
	7SR8	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.3	2022-06-08	10.1038/s41467-022-30601-3
	7SR8 (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.3	2022-06-08	10.1038/s41467-022-30601-3
	7SQO	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	Gi1/β1/γ2	3.17	2022-05-25	10.1038/s41467-022-30601-3
	7SQO (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.17	2022-05-25	10.1038/s41467-022-30601-3
	7L1V	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2021-02-10	10.1038/s41467-021-21087-6
	7L1V (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-		3	2021-02-10	10.1038/s41467-021-21087-6
	7L1U	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-02-10	10.1038/s41467-021-21087-6
	7L1U (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-		3.2	2021-02-10	10.1038/s41467-021-21087-6
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	5WS3	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.3	2017-12-13	10.1016/j.str.2017.11.005
	5WQC	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	1.96	2017-11-29	10.1016/j.str.2017.11.005
	4S0V	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.5	2015-01-14	10.1038/nature14035

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7L1V_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.