psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L108	R:R:Y61	3.52	Yes	No	0	7	7
2	R:R:L112	R:R:Y61	8.21	No	No	0	6	7
3	R:R:W351	R:R:Y61	6.75	Yes	No	0	5	7
4	R:R:V64	R:R:W351	3.68	No	Yes	0	7	5
5	R:R:F65	R:R:L69	8.53	No	No	0	6	6
6	R:R:F65	R:R:L108	4.87	No	Yes	0	6	7
7	R:R:A68	R:R:T104	5.03	No	No	0	8	7
8	R:R:I70	R:R:L74	5.71	No	No	0	4	6
9	R:R:G71	R:R:L74	3.42	No	No	0	8	6
10	R:R:N72	R:R:S97	5.96	Yes	No	0	9	9
11	R:R:D100	R:R:N72	14.81	No	Yes	6	9	9
12	R:R:N72	R:R:V101	4.43	Yes	No	0	9	7
13	R:R:N72	R:R:P361	6.52	Yes	No	6	9	9
14	R:R:S97	R:R:V75	6.46	No	No	0	9	9
15	R:R:N365	R:R:V75	7.39	No	No	0	7	9
16	R:R:C76	R:R:S97	3.44	No	No	0	6	9
17	R:R:V79	R:R:V94	3.21	No	No	0	7	6
18	R:R:K81	R:R:W80	4.64	No	No	0	6	3
19	R:R:H84	R:R:N82	7.65	No	Yes	2	5	6
20	R:R:M85	R:R:N82	7.01	Yes	Yes	2	8	6
21	R:R:E374	R:R:N82	11.83	No	Yes	2	7	6
22	R:R:H83	R:R:R86	7.9	No	No	0	7	8
23	R:R:E374	R:R:H84	7.39	No	No	2	7	5
24	R:R:M85	R:R:N90	8.41	Yes	No	0	8	9
25	R:R:F371	R:R:M85	3.73	Yes	Yes	2	8	8
26	R:R:E374	R:R:M85	5.41	No	Yes	2	7	8
27	R:R:T87	R:R:T89	4.71	No	No	0	7	8
28	R:R:N90	R:R:T87	11.7	No	No	0	9	7
29	R:R:S164	R:R:V88	3.23	No	No	0	5	6
30	R:R:C147	R:R:F92	5.59	No	Yes	0	6	8
31	R:R:F92	R:R:I148	3.77	Yes	No	0	8	8
32	R:R:D151	R:R:F92	4.78	No	Yes	0	9	8
33	R:R:A169	R:R:F92	4.16	No	Yes	0	7	8
34	R:R:F92	R:R:S172	3.96	Yes	No	0	8	6
35	R:R:I93	R:R:Y364	3.63	No	Yes	0	8	9
36	R:R:I93	R:R:N365	8.5	No	No	0	8	7
37	R:R:N95	R:R:T144	8.77	No	No	0	9	7
38	R:R:I173	R:R:N95	9.91	No	No	0	8	9
39	R:R:N95	R:R:W177	5.65	No	No	0	9	9
40	R:R:L96	R:R:T144	5.9	No	No	0	9	7
41	R:R:L145	R:R:L96	4.15	Yes	No	1	9	9
42	R:R:L96	R:R:N360	6.87	No	No	1	9	9
43	R:R:D100	R:R:S357	7.36	No	No	0	9	9
44	R:R:D100	R:R:P361	4.83	No	No	6	9	9
45	R:R:L102	R:R:S137	6.01	No	No	0	6	5
46	R:R:C107	R:R:V103	5.12	No	No	0	7	7
47	R:R:S137	R:R:V103	8.08	No	No	0	5	7
48	R:R:C107	R:R:Q134	6.1	No	No	0	7	7
49	R:R:C107	R:R:Y354	8.06	No	Yes	0	7	7
50	R:R:L108	R:R:P109	3.28	Yes	No	0	7	8
51	R:R:L108	R:R:Y354	8.21	Yes	Yes	0	7	7
52	R:R:H350	R:R:T111	17.8	Yes	No	3	5	7
53	R:R:T111	R:R:Y354	6.24	No	Yes	3	7	7
54	L:L:?1	R:R:V114	4.64	Yes	No	0	0	5
55	R:R:D115	R:R:T347	7.23	No	No	0	5	4
56	R:R:I116	R:R:T117	4.56	No	No	0	5	5
57	R:R:F121	R:R:T117	3.89	No	No	0	4	5
58	R:R:E118	R:R:Y343	22.45	No	No	0	4	3
59	R:R:F121	R:R:T119	5.19	No	No	0	4	5
60	R:R:F122	R:R:W120	15.03	No	No	0	6	7
61	R:R:C127	R:R:W120	10.45	Yes	No	4	9	7
62	R:R:C210	R:R:W120	13.06	No	No	4	9	7
63	R:R:F122	R:R:L126	7.31	No	No	0	6	5
64	R:R:K128	R:R:Q124	4.07	No	No	0	6	4
65	R:R:C193	R:R:Q124	7.63	No	No	0	4	4
66	R:R:C127	R:R:M191	3.24	Yes	No	0	9	6
67	R:R:C127	R:R:C193	3.64	Yes	No	4	9	4
68	R:R:C127	R:R:C210	7.28	Yes	No	4	9	9
69	R:R:I130	R:R:P131	5.08	No	No	0	5	5
70	R:R:C181	R:R:Y132	5.38	No	No	0	4	6
71	R:R:I185	R:R:Y132	4.84	No	No	0	5	6
72	R:R:A188	R:R:Y132	5.34	No	No	0	6	6
73	L:L:?1	R:R:Q134	23.85	Yes	No	0	0	7
74	R:R:M184	R:R:T135	6.02	Yes	No	0	7	6
75	L:L:?1	R:R:T135	9.19	Yes	No	0	0	6
76	R:R:S180	R:R:V136	3.23	No	No	0	8	5
77	R:R:C181	R:R:V136	3.42	No	No	0	4	5
78	R:R:V138	R:R:Y317	3.79	No	Yes	0	6	7
79	L:L:?1	R:R:V138	17.41	Yes	No	0	0	6
80	R:R:S139	R:R:S180	3.26	No	No	0	7	8
81	R:R:V140	R:R:W177	18.39	No	No	0	7	9
82	R:R:S180	R:R:V140	4.85	No	No	0	8	7
83	R:R:P235	R:R:V142	3.53	No	No	0	9	8
84	R:R:F313	R:R:V142	6.55	Yes	No	1	9	8
85	R:R:V142	R:R:Y317	8.83	No	Yes	1	8	7
86	R:R:F313	R:R:L145	3.65	Yes	Yes	1	9	9
87	R:R:L145	R:R:N360	5.49	Yes	No	1	9	9
88	R:R:L145	R:R:Y364	5.86	Yes	Yes	0	9	9
89	R:R:L238	R:R:S146	7.51	No	No	0	7	7
90	R:R:C147	R:R:I176	3.27	No	No	0	6	6
91	R:R:I148	R:R:R152	6.26	No	No	0	8	9
92	R:R:A149	R:R:M239	3.22	No	No	1	8	8
93	R:R:A149	R:R:Y243	5.34	No	Yes	1	8	9
94	R:R:D151	R:R:S164	5.89	No	No	0	9	5
95	R:R:R152	R:R:Y243	8.23	No	Yes	0	9	9
96	R:R:W153	R:R:Y154	8.68	Yes	Yes	0	8	4
97	R:R:C157	R:R:W153	11.75	No	Yes	7	7	8
98	R:R:H158	R:R:W153	10.58	Yes	Yes	7	6	8
99	R:R:Q245	R:R:W153	15.33	No	Yes	0	5	8
100	R:R:K163	R:R:Y154	9.55	No	Yes	0	5	4
101	R:R:R168	R:R:Y154	9.26	No	Yes	0	7	4
102	R:R:I156	R:R:I246	5.89	No	No	0	8	9
103	R:R:C157	R:R:H158	4.42	No	Yes	7	7	6
104	R:R:H158	R:R:M161	6.57	Yes	No	0	6	5
105	R:R:K163	R:R:M161	10.08	No	No	0	5	5
106	R:R:K167	R:R:N171	5.6	No	No	0	5	3
107	R:R:M184	R:R:Y223	4.79	Yes	Yes	0	7	8
108	R:R:F227	R:R:M184	4.98	No	Yes	0	5	7
109	R:R:I185	R:R:P186	5.08	No	No	0	5	6
110	R:R:P186	R:R:Y223	18.08	No	Yes	0	6	8
111	R:R:E212	R:R:Q187	5.1	Yes	No	0	4	6
112	R:R:Q187	R:R:Y223	4.51	No	Yes	0	6	8
113	L:L:?1	R:R:Q187	4.15	Yes	No	0	0	6
114	R:R:V190	R:R:W214	20.84	No	Yes	0	6	4
115	R:R:E192	R:R:R213	11.63	No	No	0	5	4
116	R:R:C193	R:R:C210	5.46	No	No	4	4	9
117	R:R:E212	R:R:W214	14.17	Yes	Yes	5	4	4
118	R:R:E212	R:R:H224	8.62	Yes	No	5	4	6
119	R:R:E212	R:R:R328	9.3	Yes	No	5	4	4
120	R:R:W214	R:R:Y219	4.82	Yes	No	0	4	3
121	R:R:P220	R:R:W214	25.67	No	Yes	0	5	4
122	R:R:W214	R:R:Y223	6.75	Yes	Yes	0	4	8
123	R:R:H224	R:R:W214	5.29	No	Yes	5	6	4
124	R:R:E217	R:R:G216	3.27	No	No	0	3	5
125	R:R:K221	R:R:M222	5.76	No	No	0	4	4
126	R:R:K221	R:R:V329	6.07	No	Yes	0	4	5
127	R:R:H224	R:R:R328	18.05	No	No	5	6	4
128	L:L:?1	R:R:F227	9.49	Yes	No	0	0	5
129	R:R:F228	R:R:L229	3.65	Yes	No	0	6	4
130	R:R:F228	R:R:M233	4.98	Yes	No	0	6	5
131	R:R:F228	R:R:S321	7.93	Yes	No	0	6	6
132	R:R:F228	R:R:V325	6.55	Yes	No	0	6	6
133	L:L:?1	R:R:T231	8.04	Yes	No	0	0	6
134	R:R:L236	R:R:Y232	5.86	No	No	0	6	8
135	R:R:L318	R:R:Y232	8.21	No	No	0	6	8
136	R:R:S321	R:R:Y232	8.9	No	No	0	6	8
137	R:R:F313	R:R:L236	3.65	Yes	No	0	9	6
138	R:R:A314	R:R:L236	4.73	No	No	0	5	6
139	R:R:M239	R:R:Y243	5.99	No	Yes	1	8	9
140	R:R:F313	R:R:M239	11.2	Yes	No	1	9	8
141	R:R:L310	R:R:V240	4.47	No	No	0	8	5
142	R:R:L306	R:R:Y243	3.52	No	Yes	0	8	9
143	R:R:V309	R:R:Y243	3.79	No	Yes	0	8	9
144	R:R:L310	R:R:Y243	4.69	No	Yes	0	8	9
145	R:R:K249	R:R:R253	8.66	No	No	0	5	7
146	R:R:L250	R:R:R299	4.86	No	No	0	8	8
147	R:R:L250	R:R:T302	4.42	No	No	0	8	8
148	R:R:R300	R:R:W251	8	No	No	0	5	5
149	R:R:C252	R:R:R253	5.57	No	No	0	5	7
150	R:R:I255	R:R:R253	5.01	No	No	0	5	7
151	R:R:K294	R:R:R297	4.95	No	No	0	3	5
152	R:R:Q295	R:R:R299	22.2	No	No	0	4	8
153	R:R:L367	R:R:M305	4.24	No	No	0	7	8
154	R:R:V309	R:R:Y364	8.83	No	Yes	0	8	9
155	R:R:I363	R:R:V312	4.61	No	No	0	8	6
156	R:R:F313	R:R:Y317	7.22	Yes	Yes	1	9	7
157	R:R:C316	R:R:N356	9.45	No	No	0	8	9
158	R:R:N356	R:R:Y317	5.81	No	Yes	0	9	7
159	R:R:L318	R:R:P319	4.93	No	No	0	6	9
160	R:R:I320	R:R:P319	3.39	Yes	No	0	7	9
161	R:R:L352	R:R:P319	4.93	No	No	0	8	9
162	R:R:I320	R:R:N324	4.25	Yes	No	3	7	7
163	R:R:I320	R:R:S349	6.19	Yes	No	0	7	6
164	R:R:I320	R:R:V353	4.61	Yes	No	0	7	7
165	L:L:?1	R:R:I320	7.78	Yes	Yes	3	0	7
166	R:R:F346	R:R:L323	8.53	No	No	0	4	5
167	L:L:?1	R:R:N324	13.91	Yes	No	3	0	7
168	R:R:V325	R:R:V329	3.21	No	Yes	0	6	5
169	R:R:L326	R:R:M332	4.24	No	No	8	5	3
170	R:R:F333	R:R:L326	3.65	Yes	No	8	4	5
171	R:R:K327	R:R:R328	13.61	No	No	0	3	4
172	R:R:F333	R:R:K327	7.44	Yes	No	0	4	3
173	R:R:F346	R:R:K327	6.2	No	No	0	4	3
174	R:R:F330	R:R:V329	3.93	No	Yes	0	3	5
175	R:R:F333	R:R:M332	12.44	Yes	No	8	4	3
176	R:R:F333	R:R:V342	9.18	Yes	Yes	0	4	5
177	R:R:E340	R:R:T341	4.23	No	No	0	1	4
178	R:R:F346	R:R:V342	6.55	No	Yes	0	4	5
179	R:R:F348	R:R:W351	4.01	No	Yes	0	4	5
180	R:R:F348	R:R:L352	9.74	No	No	0	4	8
181	R:R:H350	R:R:S349	5.58	Yes	No	0	5	6
182	R:R:H350	R:R:Y354	7.62	Yes	Yes	3	5	7
183	L:L:?1	R:R:H350	6.01	Yes	Yes	3	0	5
184	R:R:V353	R:R:Y354	5.05	No	Yes	0	7	7
185	R:R:N356	R:R:N360	5.45	No	No	0	9	9
186	R:R:A359	R:R:I362	3.25	No	No	0	6	6
187	R:R:F366	R:R:I362	5.02	No	No	0	5	6
188	R:R:I363	R:R:Y364	6.04	No	Yes	0	8	9
189	R:R:F371	R:R:N365	14.5	Yes	No	0	8	7
190	R:R:F366	R:R:F371	4.29	No	Yes	2	5	8
191	R:R:F371	R:R:S368	3.96	Yes	No	0	8	8
192	R:R:F375	R:R:F379	5.36	Yes	No	0	7	5
193	R:R:S194	R:R:T208	3.2	No	No	0	3	3
194	R:R:C237	R:R:L241	3.17	No	No	0	4	4
195	R:R:A378	R:R:N82	3.13	No	Yes	0	6	6
196	R:R:I183	R:R:V179	3.07	No	No	0	5	5
197	R:R:I183	R:R:V230	3.07	No	No	0	5	4
198	R:R:I363	R:R:V308	3.07	No	No	0	8	6
199	R:R:A110	R:R:Q134	3.03	No	No	0	4	7
200	R:R:F247	R:R:W251	3.01	No	No	0	6	5
201	R:R:K167	R:R:T165	3	No	No	0	5	5
202	R:R:L69	R:R:T104	2.95	No	No	0	6	7
203	R:R:L102	R:R:T106	2.95	No	No	0	6	5
204	R:R:L306	R:R:T302	2.95	No	No	0	8	8
205	R:R:I183	R:R:M184	2.92	No	Yes	0	5	7
206	R:R:I218	R:R:M222	2.92	No	No	0	4	4
207	R:R:I189	R:R:K128	2.91	No	No	0	5	6
208	R:R:D115	R:R:T111	2.89	No	No	0	5	7
209	R:R:Q124	R:R:S125	2.89	No	No	0	4	3
210	R:R:K370	R:R:M85	2.88	No	Yes	0	7	8
211	R:R:I58	R:R:L112	2.85	No	No	0	5	6
212	R:R:I176	R:R:L143	2.85	No	No	0	6	6
213	R:R:I246	R:R:L306	2.85	No	No	0	9	8
214	R:R:I315	R:R:L311	2.85	No	No	0	5	4
215	R:R:I322	R:R:L318	2.85	No	No	0	5	6
216	R:R:L311	R:R:M307	2.83	No	No	0	4	6
217	R:R:G60	R:R:W351	2.81	No	Yes	0	4	5
218	R:R:D115	R:R:I116	2.8	No	No	0	5	5
219	R:R:L150	R:R:L238	2.77	No	No	0	6	7
220	R:R:A303	R:R:F247	2.77	No	No	0	7	6
221	R:R:E212	R:R:M191	2.71	Yes	No	0	4	6
222	R:R:F379	R:R:V77	2.62	No	No	0	5	5
223	R:R:F371	R:R:V79	2.62	Yes	No	0	8	7
224	R:R:R339	R:R:V342	2.62	No	Yes	0	1	5
225	R:R:A242	R:R:W153	2.59	No	Yes	0	5	8
226	L:L:?1	R:R:P131	2.56	Yes	No	0	0	5
227	R:R:F65	R:R:I105	2.51	No	No	0	6	4
228	R:R:F375	R:R:L74	2.44	Yes	No	0	7	6
229	R:R:L244	R:R:R248	2.43	No	No	0	2	4
230	R:R:I246	R:R:W153	2.35	No	Yes	0	9	8
231	R:R:L150	R:R:Y154	2.34	No	Yes	0	6	4
232	R:R:L323	R:R:W345	2.28	No	No	0	5	5
233	R:R:F366	R:R:F375	2.14	No	Yes	2	5	7
234	R:R:F371	R:R:F375	2.14	Yes	Yes	2	8	7
235	R:R:R299	R:R:R300	2.13	No	No	0	8	5
236	R:R:G215	R:R:G216	2.11	No	No	0	4	5
237	R:R:A59	R:R:G60	1.95	No	No	0	4	4
238	R:R:A234	R:R:P235	1.87	No	No	0	5	9
239	R:R:A358	R:R:A68	1.79	No	No	0	5	8
240	R:R:G60	R:R:I63	1.76	No	No	0	4	3
241	R:R:A99	R:R:S141	1.71	No	No	0	8	9
242	R:R:G123	R:R:L126	1.71	No	No	0	8	5
243	R:R:A59	R:R:V56	1.7	No	No	0	4	6
244	R:R:A358	R:R:V67	1.7	No	No	0	5	5
245	R:R:A166	R:R:V88	1.7	No	No	0	3	6
246	R:R:A99	R:R:V140	1.7	No	No	0	8	7
247	R:R:L160	R:R:P159	1.64	No	No	0	7	9
248	R:R:C157	R:R:K249	1.62	No	No	0	7	5
249	R:R:A298	R:R:K294	1.61	No	No	0	6	3
250	R:R:V66	R:R:V67	1.6	No	No	0	4	5
251	R:R:T117	R:R:V113	1.59	No	No	0	5	4
252	R:R:T341	R:R:V342	1.59	No	Yes	0	4	5
253	R:R:T119	R:R:T208	1.57	No	No	0	5	3
254	R:R:I62	R:R:V66	1.54	No	No	0	3	4
255	R:R:I70	R:R:V73	1.54	No	No	0	4	4
256	R:R:I130	R:R:V129	1.54	No	No	0	5	4
257	R:R:I178	R:R:V174	1.54	No	No	0	3	3
258	R:R:I225	R:R:V329	1.54	No	Yes	0	5	5
259	R:R:H158	R:R:P159	1.53	Yes	No	0	6	9
260	R:R:A298	R:R:Q295	1.52	No	No	0	6	4
261	R:R:M305	R:R:V309	1.52	No	No	0	8	8
262	R:R:K301	R:R:T302	1.5	No	No	0	8	8
263	R:R:G369	R:R:R372	1.5	No	No	0	5	8
264	R:R:L57	R:R:V56	1.49	No	No	0	5	6
265	R:R:L133	R:R:V129	1.49	No	No	0	5	4
266	R:R:I175	R:R:I176	1.47	No	No	0	3	6
267	R:R:G215	R:R:W214	1.41	No	Yes	0	4	4
268	R:R:L310	R:R:M307	1.41	No	No	0	8	6
269	R:R:A78	R:R:F371	1.39	No	Yes	2	8	8
270	R:R:A78	R:R:F375	1.39	No	Yes	2	8	7
271	R:R:A169	R:R:Y91	1.33	No	No	0	7	4
272	R:R:R170	R:R:V174	1.31	No	No	0	4	3
273	R:R:R304	R:R:V308	1.31	No	No	0	8	6
274	R:R:D211	R:R:E192	1.3	No	No	0	5	5
275	R:R:R168	R:R:T165	1.29	No	No	0	7	5
276	R:R:H83	R:R:H84	1.19	No	No	0	7	5
277	R:R:L98	R:R:W177	1.14	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N72	7.93	4	6	9
2	R:R:N82	7.405	4	2	6
3	R:R:M85	5.488	5	2	8
4	R:R:F92	4.452	5	0	8
5	R:R:L108	4.97	4	0	7
6	R:R:C127	6.1525	4	4	9
7	R:R:L145	4.7875	4	1	9
8	R:R:W153	8.54667	6	7	8
9	R:R:Y154	7.4575	4	0	4
10	R:R:H158	5.775	4	7	6
11	R:R:M184	4.6775	4	0	7
12	R:R:E212	7.98	5	5	4
13	R:R:W214	11.2786	7	5	4
14	R:R:Y223	8.5325	4	0	8
15	R:R:F228	5.7775	4	0	6
16	R:R:Y243	5.26	6	1	9
17	R:R:F313	6.454	5	1	9
18	R:R:Y317	6.4125	4	1	7
19	R:R:I320	5.244	5	3	7
20	R:R:V329	3.6875	4	0	5
21	R:R:F333	8.1775	4	8	4
22	R:R:V342	4.985	4	0	5
23	R:R:H350	9.2525	4	3	5
24	R:R:W351	4.3125	4	0	5
25	R:R:Y354	7.036	5	3	7
26	R:R:Y364	6.09	4	0	9
27	R:R:F371	4.66143	7	2	8
28	R:R:F375	2.694	5	2	7
29	L:L:?1	9.73	11	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L108	R:R:Y61	10.9015	3.52	Yes	No	0	7	7
2	R:R:F65	R:R:L108	17.2955	4.87	No	Yes	0	6	7
3	R:R:F65	R:R:L69	13.5513	8.53	No	No	0	6	6
4	R:R:L69	R:R:T104	11.6575	2.95	No	No	0	6	7
5	R:R:F371	R:R:F375	12.1688	2.14	Yes	Yes	2	8	7
6	R:R:F371	R:R:N365	47.5302	14.5	Yes	No	0	8	7
7	R:R:I93	R:R:N365	59.9798	8.5	No	No	0	8	7
8	R:R:I93	R:R:Y364	61.2687	3.63	No	Yes	0	8	9
9	R:R:L145	R:R:Y364	57.8989	5.86	Yes	Yes	0	9	9
10	R:R:F313	R:R:L145	60.4695	3.65	Yes	Yes	1	9	9
11	R:R:F313	R:R:Y317	90.733	7.22	Yes	Yes	1	9	7
12	R:R:V138	R:R:Y317	100	3.79	No	Yes	0	6	7
13	L:L:?1	R:R:V138	99.82	17.41	Yes	No	0	0	6
14	L:L:?1	R:R:H350	46.1262	6.01	Yes	Yes	3	0	5
15	R:R:H350	R:R:Y354	27.1025	7.62	Yes	Yes	3	5	7
16	R:R:L108	R:R:Y354	29.9971	8.21	Yes	Yes	0	7	7
17	R:R:N365	R:R:V75	14.3721	7.39	No	No	0	7	9
18	R:R:S97	R:R:V75	12.8456	6.46	No	No	0	9	9
19	R:R:F371	R:R:M85	24.7192	3.73	Yes	Yes	2	8	8
20	R:R:F313	R:R:M239	66.7699	11.2	Yes	No	1	9	8
21	R:R:M239	R:R:Y243	64.9626	5.99	No	Yes	1	8	9
22	R:R:R152	R:R:Y243	25.9649	8.23	No	Yes	0	9	9
23	R:R:I148	R:R:R152	24.4312	6.26	No	No	0	8	9
24	R:R:F92	R:R:I148	22.7175	3.77	Yes	No	0	8	8
25	R:R:L145	R:R:L96	23.4087	4.15	Yes	No	1	9	9
26	R:R:L96	R:R:T144	26.0729	5.9	No	No	0	9	7
27	R:R:N95	R:R:T144	23.2719	8.77	No	No	0	9	7
28	R:R:N95	R:R:W177	17.7707	5.65	No	No	0	9	9
29	R:R:D115	R:R:T111	19.4124	2.89	No	No	0	5	7
30	R:R:D115	R:R:I116	15.2146	2.8	No	No	0	5	5
31	R:R:I116	R:R:T117	13.0832	4.56	No	No	0	5	5
32	R:R:C127	R:R:M191	21.6158	3.24	Yes	No	0	9	6
33	R:R:E212	R:R:M191	23.4951	2.71	Yes	No	0	4	6
34	R:R:E212	R:R:Q187	58.3381	5.1	Yes	No	0	4	6
35	L:L:?1	R:R:Q187	76.3105	4.15	Yes	No	0	0	6
36	R:R:C127	R:R:C193	10.0014	3.64	Yes	No	4	9	4
37	R:R:C181	R:R:Y132	10.3759	5.38	No	No	0	4	6
38	R:R:I185	R:R:Y132	13.6305	4.84	No	No	0	5	6
39	R:R:I185	R:R:P186	15.6034	5.08	No	No	0	5	6
40	R:R:P186	R:R:Y223	17.5259	18.08	No	Yes	0	6	8
41	R:R:Q187	R:R:Y223	24.4888	4.51	No	Yes	0	6	8
42	R:R:S180	R:R:V136	10.2103	3.23	No	No	0	8	5
43	R:R:V140	R:R:W177	14.0553	18.39	No	No	0	7	9
44	R:R:S180	R:R:V140	10.7719	4.85	No	No	0	8	7
45	R:R:L306	R:R:Y243	60.7071	3.52	No	Yes	0	8	9
46	R:R:I246	R:R:L306	41.0354	2.85	No	No	0	9	8
47	R:R:I246	R:R:W153	37.9536	2.35	No	Yes	0	9	8
48	R:R:W153	R:R:Y154	16.9067	8.68	Yes	Yes	0	8	4
49	R:R:E212	R:R:W214	15.0274	14.17	Yes	Yes	5	4	4
50	R:R:W214	R:R:Y223	17.2235	6.75	Yes	Yes	0	4	8
51	R:R:E212	R:R:R328	30.1627	9.3	Yes	No	5	4	4
52	R:R:G215	R:R:W214	10.4047	1.41	No	Yes	0	4	4
53	R:R:V325	R:R:V329	12.1328	3.21	No	Yes	0	6	5
54	R:R:F228	R:R:V325	14.1057	6.55	Yes	No	0	6	6
55	R:R:F228	R:R:S321	19.9381	7.93	Yes	No	0	6	6
56	R:R:S321	R:R:Y232	21.8534	8.9	No	No	0	6	8
57	R:R:L318	R:R:Y232	23.3655	8.21	No	No	0	6	8
58	R:R:L318	R:R:P319	23.3799	4.93	No	No	0	6	9
59	R:R:I320	R:R:P319	19.7221	3.39	Yes	No	0	7	9
60	R:R:F313	R:R:L236	25.108	3.65	Yes	No	0	9	6
61	R:R:L236	R:R:Y232	22.415	5.86	No	No	0	6	8
62	R:R:V309	R:R:Y364	28.0602	8.83	No	Yes	0	8	9
63	R:R:V309	R:R:Y243	27.837	3.79	No	Yes	0	8	9
64	R:R:L306	R:R:T302	22.235	2.95	No	No	0	8	8
65	R:R:L250	R:R:T302	18.8292	4.42	No	No	0	8	8
66	R:R:L250	R:R:R299	17.2163	4.86	No	No	0	8	8
67	R:R:F348	R:R:W351	11.7296	4.01	No	Yes	0	4	5
68	R:R:F348	R:R:L352	13.0976	9.74	No	No	0	4	8
69	R:R:F346	R:R:K327	14.8401	6.2	No	No	0	4	3
70	R:R:K327	R:R:R328	31.3724	13.61	No	No	0	3	4
71	R:R:F333	R:R:K327	14.6313	7.44	Yes	No	0	4	3
72	R:R:I183	R:R:M184	10.8151	2.92	No	Yes	0	5	7
73	R:R:G60	R:R:W351	11.9888	2.81	No	Yes	0	4	5
74	R:R:L352	R:R:P319	14.869	4.93	No	No	0	8	9
75	L:L:?1	R:R:I320	19.1172	7.78	Yes	Yes	3	0	7
76	L:L:?1	R:R:Q134	11.5351	23.85	Yes	No	0	0	7
77	R:R:H350	R:R:T111	17.7995	17.8	Yes	No	3	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C107	R:R:Q134	6.1	0	No	No	7	7	2	1
R:R:C107	R:R:Y354	8.06	0	No	Yes	7	7	2	2
R:R:H350	R:R:T111	17.8	3	Yes	No	5	7	1	2
R:R:T111	R:R:Y354	6.24	3	No	Yes	7	7	2	2
L:L:?1	R:R:V114	4.64	3	Yes	No	0	5	0	1
R:R:I130	R:R:P131	5.08	0	No	No	5	5	2	1
L:L:?1	R:R:Q134	23.85	3	Yes	No	0	7	0	1
R:R:M184	R:R:T135	6.02	0	Yes	No	7	6	2	1
L:L:?1	R:R:T135	9.19	3	Yes	No	0	6	0	1
R:R:V138	R:R:Y317	3.79	0	No	Yes	6	7	1	2
L:L:?1	R:R:V138	17.41	3	Yes	No	0	6	0	1
R:R:M184	R:R:Y223	4.79	0	Yes	Yes	7	8	2	2
R:R:F227	R:R:M184	4.98	0	No	Yes	5	7	1	2
R:R:E212	R:R:Q187	5.1	5	Yes	No	4	6	2	1
R:R:Q187	R:R:Y223	4.51	0	No	Yes	6	8	1	2
L:L:?1	R:R:Q187	4.15	3	Yes	No	0	6	0	1
L:L:?1	R:R:F227	9.49	3	Yes	No	0	5	0	1
L:L:?1	R:R:T231	8.04	3	Yes	No	0	6	0	1
R:R:I320	R:R:P319	3.39	3	Yes	No	7	9	1	2
R:R:I320	R:R:N324	4.25	3	Yes	No	7	7	1	1
R:R:I320	R:R:S349	6.19	3	Yes	No	7	6	1	2
R:R:I320	R:R:V353	4.61	3	Yes	No	7	7	1	2
L:L:?1	R:R:I320	7.78	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:N324	13.91	3	Yes	No	0	7	0	1
R:R:H350	R:R:S349	5.58	3	Yes	No	5	6	1	2
R:R:H350	R:R:Y354	7.62	3	Yes	Yes	5	7	1	2
L:L:?1	R:R:H350	6.01	3	Yes	Yes	0	5	0	1
R:R:V353	R:R:Y354	5.05	0	No	Yes	7	7	2	2
R:R:A110	R:R:Q134	3.03	0	No	No	4	7	2	1
L:L:?1	R:R:P131	2.56	3	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7SQO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	256
Number of Links	277
Number of Hubs	29
Number of Links mediated by Hubs	124
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	36071
Length Of Smallest Path	3
Average Path Length	12.1008
Length of Longest Path	25
Minimum Path Strength	1.425
Average Path Strength	6.47889
Maximum Path Strength	23.255
Minimum Path Correlation	0.7
Average Path Correlation	0.926637
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	49.1755
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.7021
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A6F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A6F
Name	Danavorexton
Synonyms	Methyl (2R,3S)-3-[(Methylsulfonyl)Amino]-2-{[(Cis-4-Phenylcyclohexyl)Oxy]Methyl}Piperidine-1-Carboxylate 1-piperidinecarboxylic acid, 3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)-, methyl ester, (2r,3s)- Methyl (2r,3s)-3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate Danavorexton
Identifier
Formula	C21 H32 N2 O5 S
Molecular Weight	424.554
SMILES
PubChem
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	2
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43614
Sequence	>7SQO_nogp_Chain_R W V L I A G Y I I V F V V A L I G N V L V C V A V W K N H H M R T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E T W F F G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H P L M F K S T A K R A R N S I V I I W I V S C I I M I P Q A I V M E C S T V C D E R W G G E I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I I K Q I R A R R K T A R M L M V V L L V F A I C Y L P I S I L N V L K R V F G M F R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F R E E F K A A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5WQC	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	1.96	2017-11-29	doi.org/10.1016/j.str.2017.11.005
	5WS3	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.3	2017-12-13	doi.org/10.1016/j.str.2017.11.005
	7XRR	A	Peptide	Orexin	OX₂	Homo sapiens	Lemborexant	-	-	2.89	2022-11-23	doi.org/10.1016/j.str.2022.11.001
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	doi.org/10.1021/acs.jmedchem.9b01787
	4S0V	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.5	2015-01-14	doi.org/10.1038/nature14035
	7L1U	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7L1U (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-		3.2	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7L1V	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7L1V (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-		3	2021-02-10	doi.org/10.1038/s41467-021-21087-6
	7SQO	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	Gi1/β1/γ2	3.17	2022-05-25	doi.org/10.1038/s41467-022-30601-3
	7SQO (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.17	2022-05-25	doi.org/10.1038/s41467-022-30601-3
	7SR8	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.3	2022-06-08	doi.org/10.1038/s41467-022-30601-3
	7SR8 (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.3	2022-06-08	doi.org/10.1038/s41467-022-30601-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SQO_nogp.zip

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