psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L108	R:R:Y61	3.52	Yes	No	0	7	7
2	R:R:L112	R:R:Y61	8.21	No	No	0	6	7
3	R:R:W351	R:R:Y61	6.75	Yes	No	0	5	7
4	R:R:V64	R:R:W351	3.68	No	Yes	0	7	5
5	R:R:F65	R:R:L69	8.53	No	No	0	6	6
6	R:R:F65	R:R:L108	4.87	No	Yes	0	6	7
7	R:R:A68	R:R:T104	5.03	No	No	0	8	7
8	R:R:I70	R:R:L74	5.71	No	No	0	4	6
9	R:R:G71	R:R:L74	3.42	No	No	0	8	6
10	R:R:N72	R:R:S97	5.96	Yes	No	0	9	9
11	R:R:D100	R:R:N72	14.81	No	Yes	6	9	9
12	R:R:N72	R:R:V101	4.43	Yes	No	0	9	7
13	R:R:N72	R:R:P361	6.52	Yes	No	6	9	9
14	R:R:S97	R:R:V75	6.46	No	No	0	9	9
15	R:R:N365	R:R:V75	7.39	No	No	0	7	9
16	R:R:C76	R:R:S97	3.44	No	No	0	6	9
17	R:R:V79	R:R:V94	3.21	No	No	0	7	6
18	R:R:K81	R:R:W80	4.64	No	No	0	6	3
19	R:R:H84	R:R:N82	7.65	No	Yes	2	5	6
20	R:R:M85	R:R:N82	7.01	Yes	Yes	2	8	6
21	R:R:E374	R:R:N82	11.83	No	Yes	2	7	6
22	R:R:H83	R:R:R86	7.9	No	No	0	7	8
23	R:R:E374	R:R:H84	7.39	No	No	2	7	5
24	R:R:M85	R:R:N90	8.41	Yes	No	0	8	9
25	R:R:F371	R:R:M85	3.73	Yes	Yes	2	8	8
26	R:R:E374	R:R:M85	5.41	No	Yes	2	7	8
27	R:R:T87	R:R:T89	4.71	No	No	0	7	8
28	R:R:N90	R:R:T87	11.7	No	No	0	9	7
29	R:R:S164	R:R:V88	3.23	No	No	0	5	6
30	R:R:C147	R:R:F92	5.59	No	Yes	0	6	8
31	R:R:F92	R:R:I148	3.77	Yes	No	0	8	8
32	R:R:D151	R:R:F92	4.78	No	Yes	0	9	8
33	R:R:A169	R:R:F92	4.16	No	Yes	0	7	8
34	R:R:F92	R:R:S172	3.96	Yes	No	0	8	6
35	R:R:I93	R:R:Y364	3.63	No	Yes	0	8	9
36	R:R:I93	R:R:N365	8.5	No	No	0	8	7
37	R:R:N95	R:R:T144	8.77	No	No	0	9	7
38	R:R:I173	R:R:N95	9.91	No	No	0	8	9
39	R:R:N95	R:R:W177	5.65	No	No	0	9	9
40	R:R:L96	R:R:T144	5.9	No	No	0	9	7
41	R:R:L145	R:R:L96	4.15	Yes	No	1	9	9
42	R:R:L96	R:R:N360	6.87	No	No	1	9	9
43	R:R:D100	R:R:S357	7.36	No	No	0	9	9
44	R:R:D100	R:R:P361	4.83	No	No	6	9	9
45	R:R:L102	R:R:S137	6.01	No	No	0	6	5
46	R:R:C107	R:R:V103	5.12	No	No	0	7	7
47	R:R:S137	R:R:V103	8.08	No	No	0	5	7
48	R:R:C107	R:R:Q134	6.1	No	No	0	7	7
49	R:R:C107	R:R:Y354	8.06	No	Yes	0	7	7
50	R:R:L108	R:R:P109	3.28	Yes	No	0	7	8
51	R:R:L108	R:R:Y354	8.21	Yes	Yes	0	7	7
52	R:R:H350	R:R:T111	17.8	Yes	No	3	5	7
53	R:R:T111	R:R:Y354	6.24	No	Yes	3	7	7
54	L:L:?1	R:R:V114	4.64	Yes	No	0	0	5
55	R:R:D115	R:R:T347	7.23	No	No	0	5	4
56	R:R:I116	R:R:T117	4.56	No	No	0	5	5
57	R:R:F121	R:R:T117	3.89	No	No	0	4	5
58	R:R:E118	R:R:Y343	22.45	No	No	0	4	3
59	R:R:F121	R:R:T119	5.19	No	No	0	4	5
60	R:R:F122	R:R:W120	15.03	No	No	0	6	7
61	R:R:C127	R:R:W120	10.45	Yes	No	4	9	7
62	R:R:C210	R:R:W120	13.06	No	No	4	9	7
63	R:R:F122	R:R:L126	7.31	No	No	0	6	5
64	R:R:K128	R:R:Q124	4.07	No	No	0	6	4
65	R:R:C193	R:R:Q124	7.63	No	No	0	4	4
66	R:R:C127	R:R:M191	3.24	Yes	No	0	9	6
67	R:R:C127	R:R:C193	3.64	Yes	No	4	9	4
68	R:R:C127	R:R:C210	7.28	Yes	No	4	9	9
69	R:R:I130	R:R:P131	5.08	No	No	0	5	5
70	R:R:C181	R:R:Y132	5.38	No	No	0	4	6
71	R:R:I185	R:R:Y132	4.84	No	No	0	5	6
72	R:R:A188	R:R:Y132	5.34	No	No	0	6	6
73	L:L:?1	R:R:Q134	23.85	Yes	No	0	0	7
74	R:R:M184	R:R:T135	6.02	Yes	No	0	7	6
75	L:L:?1	R:R:T135	9.19	Yes	No	0	0	6
76	R:R:S180	R:R:V136	3.23	No	No	0	8	5
77	R:R:C181	R:R:V136	3.42	No	No	0	4	5
78	R:R:V138	R:R:Y317	3.79	No	Yes	0	6	7
79	L:L:?1	R:R:V138	17.41	Yes	No	0	0	6
80	R:R:S139	R:R:S180	3.26	No	No	0	7	8
81	R:R:V140	R:R:W177	18.39	No	No	0	7	9
82	R:R:S180	R:R:V140	4.85	No	No	0	8	7
83	R:R:P235	R:R:V142	3.53	No	No	0	9	8
84	R:R:F313	R:R:V142	6.55	Yes	No	1	9	8
85	R:R:V142	R:R:Y317	8.83	No	Yes	1	8	7
86	R:R:F313	R:R:L145	3.65	Yes	Yes	1	9	9
87	R:R:L145	R:R:N360	5.49	Yes	No	1	9	9
88	R:R:L145	R:R:Y364	5.86	Yes	Yes	0	9	9
89	R:R:L238	R:R:S146	7.51	No	No	0	7	7
90	R:R:C147	R:R:I176	3.27	No	No	0	6	6
91	R:R:I148	R:R:R152	6.26	No	No	0	8	9
92	R:R:A149	R:R:M239	3.22	No	No	1	8	8
93	R:R:A149	R:R:Y243	5.34	No	Yes	1	8	9
94	R:R:D151	R:R:S164	5.89	No	No	0	9	5
95	R:R:R152	R:R:Y243	8.23	No	Yes	0	9	9
96	R:R:W153	R:R:Y154	8.68	Yes	Yes	0	8	4
97	R:R:C157	R:R:W153	11.75	No	Yes	7	7	8
98	R:R:H158	R:R:W153	10.58	Yes	Yes	7	6	8
99	R:R:Q245	R:R:W153	15.33	No	Yes	0	5	8
100	R:R:K163	R:R:Y154	9.55	No	Yes	0	5	4
101	R:R:R168	R:R:Y154	9.26	No	Yes	0	7	4
102	R:R:I156	R:R:I246	5.89	No	No	0	8	9
103	R:R:C157	R:R:H158	4.42	No	Yes	7	7	6
104	R:R:H158	R:R:M161	6.57	Yes	No	0	6	5
105	R:R:K163	R:R:M161	10.08	No	No	0	5	5
106	R:R:K167	R:R:N171	5.6	No	No	0	5	3
107	R:R:M184	R:R:Y223	4.79	Yes	Yes	0	7	8
108	R:R:F227	R:R:M184	4.98	No	Yes	0	5	7
109	R:R:I185	R:R:P186	5.08	No	No	0	5	6
110	R:R:P186	R:R:Y223	18.08	No	Yes	0	6	8
111	R:R:E212	R:R:Q187	5.1	Yes	No	0	4	6
112	R:R:Q187	R:R:Y223	4.51	No	Yes	0	6	8
113	L:L:?1	R:R:Q187	4.15	Yes	No	0	0	6
114	R:R:V190	R:R:W214	20.84	No	Yes	0	6	4
115	R:R:E192	R:R:R213	11.63	No	No	0	5	4
116	R:R:C193	R:R:C210	5.46	No	No	4	4	9
117	R:R:E212	R:R:W214	14.17	Yes	Yes	5	4	4
118	R:R:E212	R:R:H224	8.62	Yes	No	5	4	6
119	R:R:E212	R:R:R328	9.3	Yes	No	5	4	4
120	R:R:W214	R:R:Y219	4.82	Yes	No	0	4	3
121	R:R:P220	R:R:W214	25.67	No	Yes	0	5	4
122	R:R:W214	R:R:Y223	6.75	Yes	Yes	0	4	8
123	R:R:H224	R:R:W214	5.29	No	Yes	5	6	4
124	R:R:E217	R:R:G216	3.27	No	No	0	3	5
125	R:R:K221	R:R:M222	5.76	No	No	0	4	4
126	R:R:K221	R:R:V329	6.07	No	Yes	0	4	5
127	R:R:H224	R:R:R328	18.05	No	No	5	6	4
128	L:L:?1	R:R:F227	9.49	Yes	No	0	0	5
129	R:R:F228	R:R:L229	3.65	Yes	No	0	6	4
130	R:R:F228	R:R:M233	4.98	Yes	No	0	6	5
131	R:R:F228	R:R:S321	7.93	Yes	No	0	6	6
132	R:R:F228	R:R:V325	6.55	Yes	No	0	6	6
133	L:L:?1	R:R:T231	8.04	Yes	No	0	0	6
134	R:R:L236	R:R:Y232	5.86	No	No	0	6	8
135	R:R:L318	R:R:Y232	8.21	No	No	0	6	8
136	R:R:S321	R:R:Y232	8.9	No	No	0	6	8
137	R:R:F313	R:R:L236	3.65	Yes	No	0	9	6
138	R:R:A314	R:R:L236	4.73	No	No	0	5	6
139	R:R:M239	R:R:Y243	5.99	No	Yes	1	8	9
140	R:R:F313	R:R:M239	11.2	Yes	No	1	9	8
141	R:R:L310	R:R:V240	4.47	No	No	0	8	5
142	R:R:L306	R:R:Y243	3.52	No	Yes	0	8	9
143	R:R:V309	R:R:Y243	3.79	No	Yes	0	8	9
144	R:R:L310	R:R:Y243	4.69	No	Yes	0	8	9
145	R:R:K249	R:R:R253	8.66	No	No	0	5	7
146	R:R:L250	R:R:R299	4.86	No	No	0	8	8
147	R:R:L250	R:R:T302	4.42	No	No	0	8	8
148	R:R:R300	R:R:W251	8	No	No	0	5	5
149	R:R:C252	R:R:R253	5.57	No	No	0	5	7
150	R:R:I255	R:R:R253	5.01	No	No	0	5	7
151	R:R:K294	R:R:R297	4.95	No	No	0	3	5
152	R:R:Q295	R:R:R299	22.2	No	No	0	4	8
153	R:R:L367	R:R:M305	4.24	No	No	0	7	8
154	R:R:V309	R:R:Y364	8.83	No	Yes	0	8	9
155	R:R:I363	R:R:V312	4.61	No	No	0	8	6
156	R:R:F313	R:R:Y317	7.22	Yes	Yes	1	9	7
157	R:R:C316	R:R:N356	9.45	No	No	0	8	9
158	R:R:N356	R:R:Y317	5.81	No	Yes	0	9	7
159	R:R:L318	R:R:P319	4.93	No	No	0	6	9
160	R:R:I320	R:R:P319	3.39	Yes	No	0	7	9
161	R:R:L352	R:R:P319	4.93	No	No	0	8	9
162	R:R:I320	R:R:N324	4.25	Yes	No	3	7	7
163	R:R:I320	R:R:S349	6.19	Yes	No	0	7	6
164	R:R:I320	R:R:V353	4.61	Yes	No	0	7	7
165	L:L:?1	R:R:I320	7.78	Yes	Yes	3	0	7
166	R:R:F346	R:R:L323	8.53	No	No	0	4	5
167	L:L:?1	R:R:N324	13.91	Yes	No	3	0	7
168	R:R:V325	R:R:V329	3.21	No	Yes	0	6	5
169	R:R:L326	R:R:M332	4.24	No	No	8	5	3
170	R:R:F333	R:R:L326	3.65	Yes	No	8	4	5
171	R:R:K327	R:R:R328	13.61	No	No	0	3	4
172	R:R:F333	R:R:K327	7.44	Yes	No	0	4	3
173	R:R:F346	R:R:K327	6.2	No	No	0	4	3
174	R:R:F330	R:R:V329	3.93	No	Yes	0	3	5
175	R:R:F333	R:R:M332	12.44	Yes	No	8	4	3
176	R:R:F333	R:R:V342	9.18	Yes	Yes	0	4	5
177	R:R:E340	R:R:T341	4.23	No	No	0	1	4
178	R:R:F346	R:R:V342	6.55	No	Yes	0	4	5
179	R:R:F348	R:R:W351	4.01	No	Yes	0	4	5
180	R:R:F348	R:R:L352	9.74	No	No	0	4	8
181	R:R:H350	R:R:S349	5.58	Yes	No	0	5	6
182	R:R:H350	R:R:Y354	7.62	Yes	Yes	3	5	7
183	L:L:?1	R:R:H350	6.01	Yes	Yes	3	0	5
184	R:R:V353	R:R:Y354	5.05	No	Yes	0	7	7
185	R:R:N356	R:R:N360	5.45	No	No	0	9	9
186	R:R:A359	R:R:I362	3.25	No	No	0	6	6
187	R:R:F366	R:R:I362	5.02	No	No	0	5	6
188	R:R:I363	R:R:Y364	6.04	No	Yes	0	8	9
189	R:R:F371	R:R:N365	14.5	Yes	No	0	8	7
190	R:R:F366	R:R:F371	4.29	No	Yes	2	5	8
191	R:R:F371	R:R:S368	3.96	Yes	No	0	8	8
192	R:R:F375	R:R:F379	5.36	Yes	No	0	7	5
193	R:R:S194	R:R:T208	3.2	No	No	0	3	3
194	R:R:C237	R:R:L241	3.17	No	No	0	4	4
195	R:R:A378	R:R:N82	3.13	No	Yes	0	6	6
196	R:R:I183	R:R:V179	3.07	No	No	0	5	5
197	R:R:I183	R:R:V230	3.07	No	No	0	5	4
198	R:R:I363	R:R:V308	3.07	No	No	0	8	6
199	R:R:A110	R:R:Q134	3.03	No	No	0	4	7
200	R:R:F247	R:R:W251	3.01	No	No	0	6	5
201	R:R:K167	R:R:T165	3	No	No	0	5	5
202	R:R:L69	R:R:T104	2.95	No	No	0	6	7
203	R:R:L102	R:R:T106	2.95	No	No	0	6	5
204	R:R:L306	R:R:T302	2.95	No	No	0	8	8
205	R:R:I183	R:R:M184	2.92	No	Yes	0	5	7
206	R:R:I218	R:R:M222	2.92	No	No	0	4	4
207	R:R:I189	R:R:K128	2.91	No	No	0	5	6
208	R:R:D115	R:R:T111	2.89	No	No	0	5	7
209	R:R:Q124	R:R:S125	2.89	No	No	0	4	3
210	R:R:K370	R:R:M85	2.88	No	Yes	0	7	8
211	R:R:I58	R:R:L112	2.85	No	No	0	5	6
212	R:R:I176	R:R:L143	2.85	No	No	0	6	6
213	R:R:I246	R:R:L306	2.85	No	No	0	9	8
214	R:R:I315	R:R:L311	2.85	No	No	0	5	4
215	R:R:I322	R:R:L318	2.85	No	No	0	5	6
216	R:R:L311	R:R:M307	2.83	No	No	0	4	6
217	R:R:G60	R:R:W351	2.81	No	Yes	0	4	5
218	R:R:D115	R:R:I116	2.8	No	No	0	5	5
219	R:R:L150	R:R:L238	2.77	No	No	0	6	7
220	R:R:A303	R:R:F247	2.77	No	No	0	7	6
221	R:R:E212	R:R:M191	2.71	Yes	No	0	4	6
222	R:R:F379	R:R:V77	2.62	No	No	0	5	5
223	R:R:F371	R:R:V79	2.62	Yes	No	0	8	7
224	R:R:R339	R:R:V342	2.62	No	Yes	0	1	5
225	R:R:A242	R:R:W153	2.59	No	Yes	0	5	8
226	L:L:?1	R:R:P131	2.56	Yes	No	0	0	5
227	R:R:F65	R:R:I105	2.51	No	No	0	6	4
228	R:R:F375	R:R:L74	2.44	Yes	No	0	7	6
229	R:R:L244	R:R:R248	2.43	No	No	0	2	4
230	R:R:I246	R:R:W153	2.35	No	Yes	0	9	8
231	R:R:L150	R:R:Y154	2.34	No	Yes	0	6	4
232	R:R:L323	R:R:W345	2.28	No	No	0	5	5
233	R:R:F366	R:R:F375	2.14	No	Yes	2	5	7
234	R:R:F371	R:R:F375	2.14	Yes	Yes	2	8	7
235	R:R:R299	R:R:R300	2.13	No	No	0	8	5
236	R:R:G215	R:R:G216	2.11	No	No	0	4	5
237	R:R:A59	R:R:G60	1.95	No	No	0	4	4
238	R:R:A234	R:R:P235	1.87	No	No	0	5	9
239	R:R:A358	R:R:A68	1.79	No	No	0	5	8
240	R:R:G60	R:R:I63	1.76	No	No	0	4	3
241	R:R:A99	R:R:S141	1.71	No	No	0	8	9
242	R:R:G123	R:R:L126	1.71	No	No	0	8	5
243	R:R:A59	R:R:V56	1.7	No	No	0	4	6
244	R:R:A358	R:R:V67	1.7	No	No	0	5	5
245	R:R:A166	R:R:V88	1.7	No	No	0	3	6
246	R:R:A99	R:R:V140	1.7	No	No	0	8	7
247	R:R:L160	R:R:P159	1.64	No	No	0	7	9
248	R:R:C157	R:R:K249	1.62	No	No	0	7	5
249	R:R:A298	R:R:K294	1.61	No	No	0	6	3
250	R:R:V66	R:R:V67	1.6	No	No	0	4	5
251	R:R:T117	R:R:V113	1.59	No	No	0	5	4
252	R:R:T341	R:R:V342	1.59	No	Yes	0	4	5
253	R:R:T119	R:R:T208	1.57	No	No	0	5	3
254	R:R:I62	R:R:V66	1.54	No	No	0	3	4
255	R:R:I70	R:R:V73	1.54	No	No	0	4	4
256	R:R:I130	R:R:V129	1.54	No	No	0	5	4
257	R:R:I178	R:R:V174	1.54	No	No	0	3	3
258	R:R:I225	R:R:V329	1.54	No	Yes	0	5	5
259	R:R:H158	R:R:P159	1.53	Yes	No	0	6	9
260	R:R:A298	R:R:Q295	1.52	No	No	0	6	4
261	R:R:M305	R:R:V309	1.52	No	No	0	8	8
262	R:R:K301	R:R:T302	1.5	No	No	0	8	8
263	R:R:G369	R:R:R372	1.5	No	No	0	5	8
264	R:R:L57	R:R:V56	1.49	No	No	0	5	6
265	R:R:L133	R:R:V129	1.49	No	No	0	5	4
266	R:R:I175	R:R:I176	1.47	No	No	0	3	6
267	R:R:G215	R:R:W214	1.41	No	Yes	0	4	4
268	R:R:L310	R:R:M307	1.41	No	No	0	8	6
269	R:R:A78	R:R:F371	1.39	No	Yes	2	8	8
270	R:R:A78	R:R:F375	1.39	No	Yes	2	8	7
271	R:R:A169	R:R:Y91	1.33	No	No	0	7	4
272	R:R:R170	R:R:V174	1.31	No	No	0	4	3
273	R:R:R304	R:R:V308	1.31	No	No	0	8	6
274	R:R:D211	R:R:E192	1.3	No	No	0	5	5
275	R:R:R168	R:R:T165	1.29	No	No	0	7	5
276	R:R:H83	R:R:H84	1.19	No	No	0	7	5
277	R:R:L98	R:R:W177	1.14	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N72	7.93	4	6	9
2	R:R:N82	7.405	4	2	6
3	R:R:M85	5.488	5	2	8
4	R:R:F92	4.452	5	0	8
5	R:R:L108	4.97	4	0	7
6	R:R:C127	6.1525	4	4	9
7	R:R:L145	4.7875	4	1	9
8	R:R:W153	8.54667	6	7	8
9	R:R:Y154	7.4575	4	0	4
10	R:R:H158	5.775	4	7	6
11	R:R:M184	4.6775	4	0	7
12	R:R:E212	7.98	5	5	4
13	R:R:W214	11.2786	7	5	4
14	R:R:Y223	8.5325	4	0	8
15	R:R:F228	5.7775	4	0	6
16	R:R:Y243	5.26	6	1	9
17	R:R:F313	6.454	5	1	9
18	R:R:Y317	6.4125	4	1	7
19	R:R:I320	5.244	5	3	7
20	R:R:V329	3.6875	4	0	5
21	R:R:F333	8.1775	4	8	4
22	R:R:V342	4.985	4	0	5
23	R:R:H350	9.2525	4	3	5
24	R:R:W351	4.3125	4	0	5
25	R:R:Y354	7.036	5	3	7
26	R:R:Y364	6.09	4	0	9
27	R:R:F371	4.66143	7	2	8
28	R:R:F375	2.694	5	2	7
29	L:L:?1	9.73	11	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L108	R:R:Y61	10.9015	3.52	Yes	No	0	7	7
2	R:R:F65	R:R:L108	17.2955	4.87	No	Yes	0	6	7
3	R:R:F65	R:R:L69	13.5513	8.53	No	No	0	6	6
4	R:R:L69	R:R:T104	11.6575	2.95	No	No	0	6	7
5	R:R:F371	R:R:F375	12.1688	2.14	Yes	Yes	2	8	7
6	R:R:F371	R:R:N365	47.5302	14.5	Yes	No	0	8	7
7	R:R:I93	R:R:N365	59.9798	8.5	No	No	0	8	7
8	R:R:I93	R:R:Y364	61.2687	3.63	No	Yes	0	8	9
9	R:R:L145	R:R:Y364	57.8989	5.86	Yes	Yes	0	9	9
10	R:R:F313	R:R:L145	60.4695	3.65	Yes	Yes	1	9	9
11	R:R:F313	R:R:Y317	90.733	7.22	Yes	Yes	1	9	7
12	R:R:V138	R:R:Y317	100	3.79	No	Yes	0	6	7
13	L:L:?1	R:R:V138	99.82	17.41	Yes	No	0	0	6
14	L:L:?1	R:R:H350	46.1262	6.01	Yes	Yes	3	0	5
15	R:R:H350	R:R:Y354	27.1025	7.62	Yes	Yes	3	5	7
16	R:R:L108	R:R:Y354	29.9971	8.21	Yes	Yes	0	7	7
17	R:R:N365	R:R:V75	14.3721	7.39	No	No	0	7	9
18	R:R:S97	R:R:V75	12.8456	6.46	No	No	0	9	9
19	R:R:F371	R:R:M85	24.7192	3.73	Yes	Yes	2	8	8
20	R:R:F313	R:R:M239	66.7699	11.2	Yes	No	1	9	8
21	R:R:M239	R:R:Y243	64.9626	5.99	No	Yes	1	8	9
22	R:R:R152	R:R:Y243	25.9649	8.23	No	Yes	0	9	9
23	R:R:I148	R:R:R152	24.4312	6.26	No	No	0	8	9
24	R:R:F92	R:R:I148	22.7175	3.77	Yes	No	0	8	8
25	R:R:L145	R:R:L96	23.4087	4.15	Yes	No	1	9	9
26	R:R:L96	R:R:T144	26.0729	5.9	No	No	0	9	7
27	R:R:N95	R:R:T144	23.2719	8.77	No	No	0	9	7
28	R:R:N95	R:R:W177	17.7707	5.65	No	No	0	9	9
29	R:R:D115	R:R:T111	19.4124	2.89	No	No	0	5	7
30	R:R:D115	R:R:I116	15.2146	2.8	No	No	0	5	5
31	R:R:I116	R:R:T117	13.0832	4.56	No	No	0	5	5
32	R:R:C127	R:R:M191	21.6158	3.24	Yes	No	0	9	6
33	R:R:E212	R:R:M191	23.4951	2.71	Yes	No	0	4	6
34	R:R:E212	R:R:Q187	58.3381	5.1	Yes	No	0	4	6
35	L:L:?1	R:R:Q187	76.3105	4.15	Yes	No	0	0	6
36	R:R:C127	R:R:C193	10.0014	3.64	Yes	No	4	9	4
37	R:R:C181	R:R:Y132	10.3759	5.38	No	No	0	4	6
38	R:R:I185	R:R:Y132	13.6305	4.84	No	No	0	5	6
39	R:R:I185	R:R:P186	15.6034	5.08	No	No	0	5	6
40	R:R:P186	R:R:Y223	17.5259	18.08	No	Yes	0	6	8
41	R:R:Q187	R:R:Y223	24.4888	4.51	No	Yes	0	6	8
42	R:R:S180	R:R:V136	10.2103	3.23	No	No	0	8	5
43	R:R:V140	R:R:W177	14.0553	18.39	No	No	0	7	9
44	R:R:S180	R:R:V140	10.7719	4.85	No	No	0	8	7
45	R:R:L306	R:R:Y243	60.7071	3.52	No	Yes	0	8	9
46	R:R:I246	R:R:L306	41.0354	2.85	No	No	0	9	8
47	R:R:I246	R:R:W153	37.9536	2.35	No	Yes	0	9	8
48	R:R:W153	R:R:Y154	16.9067	8.68	Yes	Yes	0	8	4
49	R:R:E212	R:R:W214	15.0274	14.17	Yes	Yes	5	4	4
50	R:R:W214	R:R:Y223	17.2235	6.75	Yes	Yes	0	4	8
51	R:R:E212	R:R:R328	30.1627	9.3	Yes	No	5	4	4
52	R:R:G215	R:R:W214	10.4047	1.41	No	Yes	0	4	4
53	R:R:V325	R:R:V329	12.1328	3.21	No	Yes	0	6	5
54	R:R:F228	R:R:V325	14.1057	6.55	Yes	No	0	6	6
55	R:R:F228	R:R:S321	19.9381	7.93	Yes	No	0	6	6
56	R:R:S321	R:R:Y232	21.8534	8.9	No	No	0	6	8
57	R:R:L318	R:R:Y232	23.3655	8.21	No	No	0	6	8
58	R:R:L318	R:R:P319	23.3799	4.93	No	No	0	6	9
59	R:R:I320	R:R:P319	19.7221	3.39	Yes	No	0	7	9
60	R:R:F313	R:R:L236	25.108	3.65	Yes	No	0	9	6
61	R:R:L236	R:R:Y232	22.415	5.86	No	No	0	6	8
62	R:R:V309	R:R:Y364	28.0602	8.83	No	Yes	0	8	9
63	R:R:V309	R:R:Y243	27.837	3.79	No	Yes	0	8	9
64	R:R:L306	R:R:T302	22.235	2.95	No	No	0	8	8
65	R:R:L250	R:R:T302	18.8292	4.42	No	No	0	8	8
66	R:R:L250	R:R:R299	17.2163	4.86	No	No	0	8	8
67	R:R:F348	R:R:W351	11.7296	4.01	No	Yes	0	4	5
68	R:R:F348	R:R:L352	13.0976	9.74	No	No	0	4	8
69	R:R:F346	R:R:K327	14.8401	6.2	No	No	0	4	3
70	R:R:K327	R:R:R328	31.3724	13.61	No	No	0	3	4
71	R:R:F333	R:R:K327	14.6313	7.44	Yes	No	0	4	3
72	R:R:I183	R:R:M184	10.8151	2.92	No	Yes	0	5	7
73	R:R:G60	R:R:W351	11.9888	2.81	No	Yes	0	4	5
74	R:R:L352	R:R:P319	14.869	4.93	No	No	0	8	9
75	L:L:?1	R:R:I320	19.1172	7.78	Yes	Yes	3	0	7
76	L:L:?1	R:R:Q134	11.5351	23.85	Yes	No	0	0	7
77	R:R:H350	R:R:T111	17.7995	17.8	Yes	No	3	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C107	R:R:Q134	6.1	0	No	No	7	7	2	1
R:R:C107	R:R:Y354	8.06	0	No	Yes	7	7	2	2
R:R:H350	R:R:T111	17.8	3	Yes	No	5	7	1	2
R:R:T111	R:R:Y354	6.24	3	No	Yes	7	7	2	2
L:L:?1	R:R:V114	4.64	3	Yes	No	0	5	0	1
R:R:I130	R:R:P131	5.08	0	No	No	5	5	2	1
L:L:?1	R:R:Q134	23.85	3	Yes	No	0	7	0	1
R:R:M184	R:R:T135	6.02	0	Yes	No	7	6	2	1
L:L:?1	R:R:T135	9.19	3	Yes	No	0	6	0	1
R:R:V138	R:R:Y317	3.79	0	No	Yes	6	7	1	2
L:L:?1	R:R:V138	17.41	3	Yes	No	0	6	0	1
R:R:M184	R:R:Y223	4.79	0	Yes	Yes	7	8	2	2
R:R:F227	R:R:M184	4.98	0	No	Yes	5	7	1	2
R:R:E212	R:R:Q187	5.1	5	Yes	No	4	6	2	1
R:R:Q187	R:R:Y223	4.51	0	No	Yes	6	8	1	2
L:L:?1	R:R:Q187	4.15	3	Yes	No	0	6	0	1
L:L:?1	R:R:F227	9.49	3	Yes	No	0	5	0	1
L:L:?1	R:R:T231	8.04	3	Yes	No	0	6	0	1
R:R:I320	R:R:P319	3.39	3	Yes	No	7	9	1	2
R:R:I320	R:R:N324	4.25	3	Yes	No	7	7	1	1
R:R:I320	R:R:S349	6.19	3	Yes	No	7	6	1	2
R:R:I320	R:R:V353	4.61	3	Yes	No	7	7	1	2
L:L:?1	R:R:I320	7.78	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:N324	13.91	3	Yes	No	0	7	0	1
R:R:H350	R:R:S349	5.58	3	Yes	No	5	6	1	2
R:R:H350	R:R:Y354	7.62	3	Yes	Yes	5	7	1	2
L:L:?1	R:R:H350	6.01	3	Yes	Yes	0	5	0	1
R:R:V353	R:R:Y354	5.05	0	No	Yes	7	7	2	2
R:R:A110	R:R:Q134	3.03	0	No	No	4	7	2	1
L:L:?1	R:R:P131	2.56	3	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7SQO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	256
Number of Links	277
Number of Hubs	29
Number of Links mediated by Hubs	124
Number of Communities	8
Number of Nodes involved in Communities	40
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	36071
Length Of Smallest Path	3
Average Path Length	12.1008
Length of Longest Path	25
Minimum Path Strength	1.425
Average Path Strength	6.47889
Maximum Path Strength	23.255
Minimum Path Correlation	0.7
Average Path Correlation	0.926669
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	49.1755
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.7021
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • locomotion • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • circadian sleep/wake cycle • multicellular organismal process • rhythmic behavior • circadian rhythm • regulation of circadian sleep/wake cycle • regulation of circadian sleep/wake cycle, wakefulness • regulation of circadian rhythm • behavior • regulation of behavior • circadian behavior • circadian sleep/wake cycle, wakefulness • regulation of multicellular organismal process • circadian sleep/wake cycle process • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • regulation of cytosolic calcium ion concentration • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • feeding behavior • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A6F
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A6F
Name	Danavorexton
Synonyms	Danavorexton Methyl (2r,3s)-3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)piperidine-1-carboxylate Methyl (2R,3S)-3-[(Methylsulfonyl)Amino]-2-{[(Cis-4-Phenylcyclohexyl)Oxy]Methyl}Piperidine-1-Carboxylate 1-piperidinecarboxylic acid, 3-((methylsulfonyl)amino)-2-(((cis-4-phenylcyclohexyl)oxy)methyl)-, methyl ester, (2r,3s)-
Identifier
Formula	C21 H32 N2 O5 S
Molecular Weight	424.554
SMILES
PubChem
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	2
Total Bonds	63
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43614
Sequence	>7SQO_nogp_Chain_R W V L I A G Y I I V F V V A L I G N V L V C V A V W K N H H M R T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E T W F F G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H P L M F K S T A K R A R N S I V I I W I V S C I I M I P Q A I V M E C S T V C D E R W G G E I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I I K Q I R A R R K T A R M L M V V L L V F A I C Y L P I S I L N V L K R V F G M F R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F R E E F K A A F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XRR	A	Peptide	Orexin	OX₂	Homo sapiens	Lemborexant	-	-	2.89	2022-11-23	10.1016/j.str.2022.11.001
	7SR8	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.3	2022-06-08	10.1038/s41467-022-30601-3
	7SR8 (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.3	2022-06-08	10.1038/s41467-022-30601-3
	7SQO	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-	Gi1/β1/γ2	3.17	2022-05-25	10.1038/s41467-022-30601-3
	7SQO (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	TAK-925	-		3.17	2022-05-25	10.1038/s41467-022-30601-3
	7L1V	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2021-02-10	10.1038/s41467-021-21087-6
	7L1V (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	PubChem 155491009	-		3	2021-02-10	10.1038/s41467-021-21087-6
	7L1U	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2021-02-10	10.1038/s41467-021-21087-6
	7L1U (No Gprot)	A	Peptide	Orexin	OX₂	Homo sapiens	Orexin	-		3.2	2021-02-10	10.1038/s41467-021-21087-6
	6TPN	A	Peptide	Orexin	OX₂	Homo sapiens	HTL6641	-	-	2.61	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPJ	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	6TPG	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.74	2020-01-01	10.1021/acs.jmedchem.9b01787
	5WS3	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	2.3	2017-12-13	10.1016/j.str.2017.11.005
	5WQC	A	Peptide	Orexin	OX₂	Homo sapiens	EMPA	-	-	1.96	2017-11-29	10.1016/j.str.2017.11.005
	4S0V	A	Peptide	Orexin	OX₂	Homo sapiens	Suvorexant	-	-	2.5	2015-01-14	10.1038/nature14035

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