Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:K53 5.675421
2R:R:F92 5.85508
3R:R:D100 6.104519
4R:R:M108 5.33333618
5R:R:W121 6.89143717
6R:R:L123 7.9475416
7R:R:C128 5.2519
8R:R:W131 5.71616
9R:R:D135 9.6625418
10R:R:F138 8.615416
11R:R:H145 8.476518
12R:R:Y154 6.93408
13R:R:W180 3.97571719
14R:R:I188 4.5675404
15R:R:I205 4.6175412
16R:R:C207 5.9025419
17R:R:F214 7.7725415
18R:R:F217 6.542517
19R:R:S222 4.87417
20R:R:F226 8.044508
21R:R:P229 6.1425409
22R:R:M233 5.4475418
23R:R:F330 6.11571718
24R:R:F333 6.95857719
25R:R:W337 8.01167618
26R:R:F340 12.54417
27R:R:F341 10.794517
28R:R:N344 5.786516
29R:R:V348 3.09465
30R:R:F365 5.7405
31R:R:W367 6.51125817
32R:R:Y370 6.428518
33R:R:S373 5.9075419
34R:R:P377 6.0925419
35R:R:F387 8.78667639
36R:R:F391 4.85637
37R:R:Y394 6.09667645
38L:L:?1 9.050831210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I115 R:R:W367 11.19073.52NoYes057
2R:R:V366 R:R:W367 58.2343.68NoYes167
3L:L:?1 R:R:V366 80.25736.21YesNo106
4L:L:?1 R:R:W131 48.75373.8YesYes106
5R:R:W121 R:R:W131 30.28326.56YesYes176
6R:R:P122 R:R:W121 11.78445.4NoYes037
7R:R:I65 R:R:M108 26.31117.29NoYes068
8R:R:M108 R:R:W367 19.62496.98YesYes187
9R:R:L112 R:R:W367 17.97113.42NoYes067
10R:R:M108 R:R:T68 10.58766.02YesNo088
11R:R:I65 R:R:I69 28.13462.94NoNo067
12R:R:I69 R:R:L105 14.08384.28NoNo075
13R:R:F391 R:R:T381 43.84395.19YesNo377
14R:R:T381 R:R:V75 81.49184.76NoNo079
15R:R:A97 R:R:V75 83.28233.39NoNo099
16R:R:A97 R:R:N72 90.35013.13NoNo099
17R:R:D100 R:R:N72 73.95286.73YesNo199
18R:R:D100 R:R:S373 1004.42YesYes199
19R:R:S373 R:R:W337 94.04427.41YesYes198
20R:R:F340 R:R:W337 76.1257.02YesYes178
21L:L:?1 R:R:F340 58.733524.38YesYes107
22R:R:F341 R:R:W337 61.51826.01YesYes178
23L:L:?1 R:R:F341 74.60778.13YesYes107
24R:R:F333 R:R:W337 39.395910.02YesYes198
25R:R:F333 R:R:N376 10.54529.67YesNo199
26R:R:N376 R:R:P377 12.91996.52NoYes199
27R:R:F391 R:R:L74 21.34019.74YesNo077
28R:R:L74 R:R:Y394 19.2483.52NoYes075
29R:R:F387 R:R:T381 35.843214.27YesNo397
30R:R:F387 R:R:N90 25.46297.25YesNo099
31R:R:N90 R:R:V79 15.03562.96NoNo098
32R:R:V79 R:R:Y91 10.78552.52NoNo085
33R:R:F92 R:R:H145 27.347711.31YesYes088
34R:R:H145 R:R:L96 49.86111.57YesNo189
35R:R:D100 R:R:L96 41.0315.43YesNo199
36R:R:F92 R:R:I149 21.55685.02YesNo089
37R:R:F330 R:R:I149 22.50865.02YesNo089
38R:R:F330 R:R:L146 32.56849.74YesNo189
39R:R:F333 R:R:L146 30.55658.53YesNo199
40L:L:?1 R:R:F217 33.03029.14YesYes107
41R:R:F217 R:R:P189 14.861210.11YesNo078
42R:R:I188 R:R:P189 13.57965.08YesNo048
43R:R:F133 R:R:I188 10.52633.77NoYes064
44R:R:F133 R:R:L134 18.06063.65NoNo065
45R:R:F138 R:R:L134 17.34917.31YesNo065
46R:R:F138 R:R:W180 15.37484.01YesYes169
47R:R:F217 R:R:V190 10.63475.24YesNo076
48R:R:H145 R:R:W180 23.86564.23YesYes189
49R:R:G104 R:R:M108 10.58765.24NoYes068
50R:R:D135 R:R:Y370 20.75115.75YesYes188
51R:R:S183 R:R:W180 14.83773.71NoYes189
52R:R:S183 R:R:T140 11.90693.2NoNo187
53R:R:F226 R:R:F341 23.347319.29YesYes087
54R:R:F226 R:R:I143 12.79743.77YesNo088
55R:R:I143 R:R:P229 14.22043.39NoYes089
56R:R:F333 R:R:L334 11.23313.65YesNo095
57R:R:F92 R:R:K175 34.6042.48YesNo086
58R:R:Q162 R:R:Y166 19.02184.51NoNo055
59R:R:T171 R:R:Y166 25.28862.5NoNo075
60R:R:K175 R:R:T171 28.40793NoNo067
61L:L:?1 R:R:L209 10.25773.46YesNo005
62R:R:F214 R:R:F217 10.12114.29YesYes157
63L:L:?1 R:R:N344 19.39885.73YesYes106
64R:R:L362 R:R:N344 17.2035.49NoYes056
65R:R:L347 R:R:M218 15.68584.24NoNo046
66R:R:M218 R:R:N344 26.10858.41NoYes066
67R:R:M108 R:R:Y370 37.77984.79YesYes188
68R:R:V366 R:R:Y370 20.529610.09NoYes168
69L:L:?1 R:R:D135 23.879822.64YesYes108
70R:R:N72 R:R:P377 18.1366.52NoYes199
71R:R:L96 R:R:P377 10.57813.28NoYes199
72R:R:F333 R:R:I143 10.6636.28YesNo098
73R:R:F340 R:R:N344 20.36474.83YesYes176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D135 R:R:V107 5.84 1 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 1 No Yes 7 8 2 2
R:R:I110 R:R:W131 12.92 0 No Yes 5 6 2 1
R:R:T114 R:R:W131 3.64 0 No Yes 5 6 2 1
R:R:W121 R:R:W131 6.56 1 Yes Yes 7 6 2 1
R:R:C207 R:R:W121 9.14 1 Yes Yes 9 7 2 2
R:R:L132 R:R:W131 3.42 0 No Yes 5 6 2 1
R:R:C207 R:R:W131 3.92 1 Yes Yes 9 6 2 1
L:L:?1 R:R:W131 3.8 1 Yes Yes 0 6 0 1
R:R:D135 R:R:S139 4.42 1 Yes No 8 7 1 1
R:R:D135 R:R:Y370 5.75 1 Yes Yes 8 8 1 2
L:L:?1 R:R:D135 22.64 1 Yes Yes 0 8 0 1
R:R:A187 R:R:V136 3.39 0 No No 8 7 2 1
R:R:F217 R:R:V136 3.93 1 Yes No 7 7 1 1
L:L:?1 R:R:V136 13.67 1 Yes No 0 7 0 1
L:L:?1 R:R:S139 6.26 1 Yes No 0 7 0 1
R:R:F217 R:R:P189 10.11 1 Yes No 7 8 1 2
R:R:F217 R:R:V190 5.24 1 Yes No 7 6 1 2
R:R:F214 R:R:L209 9.74 1 Yes No 5 5 2 1
L:L:?1 R:R:L209 3.46 1 Yes No 0 5 0 1
R:R:F214 R:R:F217 4.29 1 Yes Yes 5 7 2 1
L:L:?1 R:R:F217 9.14 1 Yes Yes 0 7 0 1
R:R:M218 R:R:N344 8.41 0 No Yes 6 6 2 1
R:R:F341 R:R:S222 6.61 1 Yes Yes 7 7 1 1
R:R:N344 R:R:S222 4.47 1 Yes Yes 6 7 1 1
R:R:I345 R:R:S222 4.64 0 No Yes 6 7 2 1
L:L:?1 R:R:S222 3.76 1 Yes Yes 0 7 0 1
R:R:F226 R:R:F341 19.29 0 Yes Yes 8 7 2 1
R:R:F340 R:R:W337 7.02 1 Yes Yes 7 8 1 2
R:R:F341 R:R:W337 6.01 1 Yes Yes 7 8 1 2
R:R:F340 R:R:F341 13.93 1 Yes Yes 7 7 1 1
R:R:F340 R:R:N344 4.83 1 Yes Yes 7 6 1 1
L:L:?1 R:R:F340 24.38 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F341 8.13 1 Yes Yes 0 7 0 1
R:R:L362 R:R:N344 5.49 0 No Yes 5 6 2 1
L:L:?1 R:R:N344 5.73 1 Yes Yes 0 6 0 1
R:R:V366 R:R:W367 3.68 1 No Yes 6 7 1 2
R:R:V366 R:R:Y370 10.09 1 No Yes 6 8 1 2
L:L:?1 R:R:V366 6.21 1 Yes No 0 6 0 1
R:R:W367 R:R:Y370 7.72 1 Yes Yes 7 8 2 2
L:L:?1 R:R:G221 1.43 1 Yes No 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
78.57Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
78.57Single6WGTLSD6WGT-5-HT2A-LSD
76.92Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
76.92Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
76.92Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
75.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
75.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
73.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
71.43Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
71.43Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
71.43Single6E67BI1671076E67-β2-BI167107-Gs (fused)
71.43Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
71.43Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
71.43Single6PS6Timolol6PS6-β2-Timolol
71.43Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
71.43Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
71.43Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
71.43Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
71.43Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
71.43Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
69.23Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
69.23Single6PS4ICI 118-5516PS4-β2-ICI 118-551
69.23Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
69.23Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GGKEpinephrine8GGK-β2-Epinephrine
69.23Single8GGMEpinephrine8GGM-β2-Epinephrine
69.23Single8GGPEpinephrine8GGP-β2-Epinephrine
69.23Single8GGQEpinephrine8GGQ-β2-Epinephrine
69.23Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
69.23Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
68.75Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
68.75Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
68.75Single7UM4AS26747237UM4-5-HT5A-AS2674723
68.75Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
68.75Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Single3P0GBI1671073P0G-β2-BI167107
66.67Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
66.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
66.67Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
66.67Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
66.67Single6H7JIsoprenaline6H7J-β1-Isoprenaline
66.67Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
66.67Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
66.67Single8GGSEpinephrine8GGS-β2-Epinephrine
66.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht5_offOrthosteric Ligand5ht5a_off
66.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
66.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
66.67Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
64.29Single2Y02Carmoterol2Y02-β1-Carmoterol
64.29Single2Y04Salbutamol2Y04-β1-Salbutamol
64.29Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
64.29Single3NY8ICI 118-5513NY8-β2-ICI 118-551
64.29Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
64.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.29Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
64.29Single6H7MSalbutamol6H7M-β1-Salbutamol
64.29Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
64.29Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
64.29Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
64.29Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
64.29Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
64.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
64.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
64.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
64.29Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
64.29Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8GGJEpinephrine8GGJ-β2-Epinephrine
64.29Single8GGNEpinephrine8GGN-β2-Epinephrine
64.29Single8GGOEpinephrine8GGO-β2-Epinephrine
64.29Single8GGUEpinephrine8GGU-β2-Epinephrine
64.29Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
64.29Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
64.29Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
64.29Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
64.29Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
62.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
62.50Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
62.50Single4AMIBucindolol4AMI-β1-Bucindolol
62.50Single4LDEBI1671074LDE-β2-BI167107
62.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
62.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
62.50Single8JJ8Formoterol8JJ8-β2-Formoterol
62.50Single8JJLOlodaterol8JJL-β2-Olodaterol
62.50Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single6KUXRS-799486KUX-α2a-RS-79948
61.54Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
61.54Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
61.54Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
61.54Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
61.54Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8GGVEpinephrine8GGV-β2-Epinephrine
61.54Single8GGXEpinephrine8GGX-β2-Epinephrine
61.54Single8GH0Epinephrine8GH0-β2-Epinephrine
61.54Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
61.54Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
61.54Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
61.54Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
61.54Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.11Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
60.00Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
60.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
60.00Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
60.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
60.00Single7WC6LSD7WC6-5-HT2A-LSD
60.00Single7XKAEpinephrine7XKA-β2-Epinephrine
60.00Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
60.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
60.00Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
60.00Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
60.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
60.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
60.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
60.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
60.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
58.82Single6H7LDobutamine6H7L-β1-Dobutamine
58.82Single6IBLArformoterol6IBL-β1-Arformoterol
58.33Single8GGREpinephrine8GGR-β2-Epinephrine
57.14Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
57.14Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
57.14Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
57.14Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
57.14Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
57.14Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8GGIEpinephrine8GGI-β2-Epinephrine
57.14Single8GGLEpinephrine8GGL-β2-Epinephrine
57.14Single8GGTEpinephrine8GGT-β2-Epinephrine
57.14Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
57.14Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
56.25Single2YDVNECA2YDV-A2A-NECA
56.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
56.25Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
56.25Single4UHRCGS216804UHR-A2A-CGS21680
56.25Single5G53NECA5G53-A2A-NECA-Gs
56.25Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
56.25Single7B6WCyclazosin7B6W-α1b-Cyclazosin
56.25Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
56.25Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
56.25Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
56.25Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
56.25Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
56.25Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
56.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
56.25Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
56.25Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
56.25Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
56.25Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
55.56Single3NY9PubChem 9131033NY9-β2-PubChem 913103
53.85Single3PBLEticlopride3PBL-D3-Eticlopride
53.85Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
53.85Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.85Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
53.85Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
53.85Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
53.85Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
53.85Single8GGYEpinephrine8GGY-β2-Epinephrine
53.85Single8GH1Epinephrine8GH1-β2-Epinephrine
53.85Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.85Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
53.33Single2Y01Dobutamine2Y01-β1-Dobutamine
53.33Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
53.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
53.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
53.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.33Single6PS1Timolol6PS1-β2-Timolol
53.33Single7BU7BI1671077BU7-β1-BI167107
53.33Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
53.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
53.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
53.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.33Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
53.33Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
53.33Single8JJOAlprenolol8JJO-β2-Alprenolol
53.33Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
53.33Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
53.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
53.33Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
53.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
53.33Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
53.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
52.94Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
52.94Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
52.94Single6MXTSalmeterol6MXT-β2-Salmeterol
52.94Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
52.94Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
52.94Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
52.94Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
52.94Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
52.63Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
50.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
50.00Single2Y00Dobutamine2Y00-β1-Dobutamine
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single5C1MBU725C1M-μ-BU72
50.00Single5WIUNemonapride5WIU-D4-Nemonapride
50.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
50.00Single5XPRBosentan5XPR-ETB-Bosentan
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
50.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
50.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
50.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
50.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
50.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
50.00Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
50.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
50.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
50.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGWEpinephrine8GGW-β2-Epinephrine
50.00Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
50.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
50.00Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
50.00Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
50.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
50.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
50.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
50.00Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
50.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
50.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
50.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
47.37Single4UG2CGS216804UG2-A2A-CGS21680
47.37Single8X5YAstemizole8X5Y-H1-Astemizole
47.06Single4RWADIPP-NH24RWA-δ-DIPP-NH2
47.06Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
47.06Single5V54Methiothepin5V54-5-HT1B-Methiothepin
47.06Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
47.06Single6J21Aprepitant6J21-NK1-Aprepitant
47.06Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
47.06Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
47.06Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
47.06Single8E0GBU728E0G-μ-BU72
47.06Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
47.06Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
47.06Consensus5ht1_offOrthosteric Ligand5ht1b_off
47.06Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
47.06Consensusa2_onOrthosteric Liganda2a_on a2b_on
47.06Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
47.06Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
47.06Consensushistamine_offOrthosteric Ligandh1_off
47.06Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
47.06Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
47.06Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
46.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.67Single6A94Zotepine6A94-5-HT2A-Zotepine
46.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
46.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.67Single6TPGEMPA6TPG-OX2-EMPA
46.67Single6TPNHTL66416TPN-OX2-HTL6641
46.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
46.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
46.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
46.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
46.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
46.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
46.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
46.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
46.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
46.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
46.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
46.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
46.67Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
46.15Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8GGZEpinephrine8GGZ-β2-Epinephrine
46.15Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
46.15Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
45.45Single7C61Ergotamine7C61-5-HT1B-Ergotamine
45.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
45.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
44.44Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
44.44Single5CXVTiotropium5CXV-M1-Tiotropium
44.44Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
44.44Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
44.44Single7YITNalfurafine7YIT-κ-Nalfurafine
44.44Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
44.44Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
44.44Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
44.44Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
44.44Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
43.75Single4DAJTiotropium4DAJ-M3-Tiotropium
43.75Single4EJ4Naltrindole4EJ4-δ-Naltrindole
43.75Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
43.75Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
43.75Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
43.75Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
43.75Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
43.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
43.75Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
43.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
43.75Single7UL4Alvimopan7UL4-μ-Alvimopan
43.75Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
43.75Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
43.75Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
43.75Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
43.75Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
43.75Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
43.75Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
43.75Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
43.75Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single8X63Mepyramine8X63-H1-Mepyramine
43.75Single8X64Desloratadine8X64-H1-Desloratadine
43.75Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
43.75Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
43.75Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
43.75Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
43.75Consensustar_onOrthosteric Ligandta1_on
42.86Single6HLLCP999946HLL-NK1-CP99994
42.86Single6HLOAprepitant6HLO-NK1-Aprepitant
42.86Single6TP4ACT-4622066TP4-OX1-ACT-462206
42.86Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
42.86Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
42.86Single7SRQLSD7SRQ-5-HT2B-LSD
42.86Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
42.86Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
42.86Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
42.86Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
42.11Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
42.11Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
42.11Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
42.11Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
42.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
42.11Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
42.11Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
42.11Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
42.11Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
42.11Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
42.11Consensusendothelin_offOrthosteric Ligandetb_off
42.11Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
42.11Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
41.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single5WQCEMPA5WQC-OX2-EMPA
41.18Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
41.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
41.18Single6TP6Filorexant6TP6-OX1-Filorexant
41.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
41.18Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
41.18Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
41.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
41.18Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
40.91Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
40.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
40.00Single5ZTYAM102575ZTY-CB2-AM10257
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
40.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
40.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single6PT3DPI-2876PT3-δ-DPI-287
40.00Single6TODEMPA6TOD-OX1-EMPA-Na
40.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
40.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
40.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
40.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
40.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
40.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
40.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8IWESpermidine8IWE-TAAR9-Spermidine
40.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
40.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
38.89Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
38.89Single4DJHJDTic4DJH-κ-JDTic
38.89Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
38.89Single4U15Tiotropium4U15-M3-Tiotropium
38.89Single5X93K-87945X93-ETB-K-8794
38.89Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
38.89Single6J20Aprepitant6J20-NK1-Aprepitant
38.89Single6OL9Tiotropium6OL9-M5-Tiotropium
38.89Single6TQ7SB-3348676TQ7-OX1-SB-334867
38.89Single7EPENAM5637EPE-mGlu-NAM563
38.89Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
38.89Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
38.89Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
38.89Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
38.89Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
38.89Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
38.89Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
38.89Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
38.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.89Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.89Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
38.89Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
38.89Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
38.89Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
38.89Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.46Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
38.46Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.46Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
38.10Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
38.10Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
38.10Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
37.50Single2YDOAdenosine2YDO-A2A-Adenosine
37.50Single3RZECidoxepin3RZE-H1-Cidoxepin
37.50Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
37.50Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
37.50Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
37.50Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
37.50Single4ZJCSB-6740424ZJC-OX1-SB-674042
37.50Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
37.50Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
37.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
37.50Single6VI4JDTic6VI4-κ-JDTic
37.50Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
37.50Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
37.50Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
37.50Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
37.50Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
37.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
37.50Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
37.50Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
37.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
37.50Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
37.50Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
37.50Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
37.50Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
36.84Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.84Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
36.84Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
36.84Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
36.84Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
36.84Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
36.84Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8WU1KCA8WU1-CB1-KCA-Arrestin1
36.84Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
36.84Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
36.84Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Single3QAKUK-4320973QAK-A2A-UK-432097
36.36Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.36Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
36.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
35.71Single3UZAGTPL92363UZA-A2A-GTPL9236
35.71Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
35.71Single6ME9Ramelteon6ME9-MT2-Ramelteon
35.71Single7WC5Psilocin7WC5-5-HT2A-Psilocin
35.71Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
35.29Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
35.29Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single4MQSIperoxo4MQS-M2-Iperoxo
35.29Single4U14Tiotropium4U14-M3-Tiotropium
35.29Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
35.29Single5DSGTiotropium5DSG-M4-Tiotropium
35.29Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
35.29Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
35.29Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
35.29Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
35.29Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
35.29Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
35.29Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
35.29Single6TOTLemborexant6TOT-OX1-Lemborexant
35.29Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
35.29Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
35.29Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
35.29Single8CU6LJ-45178CU6-A2A-LJ-4517
35.29Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
35.29Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
35.29Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
35.29Consensusadenosine_onOrthosteric Liganda1_on a2_on
35.29Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
35.29Consensushistamine_onOrthosteric Ligandh1_on h4_on
35.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
35.29Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
35.29Consensusnucleotide_onOrthosteric Ligandadenosine_on
35.29Consensustachykinin_offOrthosteric Ligandnk1_off
35.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
35.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
35.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
35.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
35.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
35.00Single7EZCUKA7EZC-A2A-UKA
35.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
35.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
35.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
35.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
35.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
35.00Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
35.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
35.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
35.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusorexin_onOrthosteric Ligandox2_on
35.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
34.78Single5WF5UK-4320975WF5-A2A-UK-432097
34.78Single6PT2KGCHM076PT2-δ-KGCHM07
34.78Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.78Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
34.78Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
34.78Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
33.33Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
33.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
33.33Single5NM2ZM2413855NM2-A2A-ZM241385-Na
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
33.33Single5WF6UK-4320975WF6-A2A-UK-432097
33.33Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Single6LUQHaloperidol6LUQ-D2-Haloperidol
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
33.33Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SK9CCX6627SK9-ACKR3-CCX662
33.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
33.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
33.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8EA0Iperoxo8EA0-M3-Iperoxo
33.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
33.33Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
33.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
33.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
33.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
33.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
33.33Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
33.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
31.82Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
31.82Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
31.82Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.82Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
31.82Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
31.82Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.82Consensussst_onOrthosteric Ligandsst2_on sst4_on
31.58Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
31.58Single5XR8AM8415XR8-CB1-AM841
31.58Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
31.58Single6E59L-7607356E59-NK1-L-760735
31.58Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.58Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.58Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
31.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
31.58Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
31.58Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.58Single7W41PD1762527W41-BB2-PD176252
31.58Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
31.58Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
31.58Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
31.58Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
31.58Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
31.58Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
31.58Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.58Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
31.58Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
31.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.58Consensusbombesin_offOrthosteric Ligandbb2_off
31.58Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
31.58Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.58Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Consensuslpa_offOrthosteric Ligandlpa1_off
31.58Consensuslpa_onOrthosteric Ligandlpa1_on
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
31.25Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
31.25Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
31.25Single5DHHSB-6121115DHH-NOP-SB-612111
31.25Single5K2DZM2413855K2D-A2A-ZM241385
31.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
31.25Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
31.25Single5WS3EMPA5WS3-OX2-EMPA
31.25Single6B73PubChem 1319551386B73-κ-PubChem 131955138
31.25Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
31.25Single6JZHZM2413856JZH-A2A-ZM241385-Na
31.25Single6PS7ZM2413856PS7-A2A-ZM241385-Na
31.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.25Single7F8ULintitript7F8U-CCKA-Lintitript
31.25Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.25Single8GNGIstradefylline8GNG-A2A-Istradefylline
31.25Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
31.25Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
31.25Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
31.25Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
31.25Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.25Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
31.25Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
31.25Consensusmglu_onOther Ligandmglu2_on mglu4_on
31.25Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
30.77Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
30.77Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.77Single8PWNTheophylline8PWN-A2A-Theophylline
30.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.43Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
30.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
30.00Single6A93Risperidone6A93-5-HT2A-Risperidone
30.00Single6CM4Risperidone6CM4-D2-Risperidone
30.00Single6HLPNetupitant6HLP-NK1-Netupitant
30.00Single7DFPSpiperone7DFP-D2-Spiperone
30.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
30.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
30.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
30.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
30.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
30.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
30.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
30.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
30.00Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
30.00Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
30.00Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
30.00Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
30.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
30.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
30.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
29.63Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
29.41Single3REYPubChem 56973REY-A2A-PubChem 5697
29.41Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.41Single5IU4ZM2413855IU4-A2A-ZM241385-Na
29.41Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.41Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.41Single5JTBZM2413855JTB-A2A-ZM241385
29.41Single5K2BZM2413855K2B-A2A-ZM241385-Na
29.41Single5K2CZM2413855K2C-A2A-ZM241385-Na
29.41Single5NLXZM2413855NLX-A2A-ZM241385-Na
29.41Single5NM4ZM2413855NM4-A2A-ZM241385-Na
29.41Single6AQFZM2413856AQF-A2A-ZM241385
29.41Single6IQLL7458706IQL-D4-L745870
29.41Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
29.41Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
29.41Single6TP3Nemorexant6TP3-OX1-Nemorexant
29.41Single6V9SGTPL114036V9S-OX1-GTPL11403
29.41Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.41Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
29.41Single7AROLUF58337ARO-A2A-LUF5833-Na
29.41Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
29.41Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
29.41Single7T32ZM2413857T32-A2A-ZM241385
29.41Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
29.41Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
29.41Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.41Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
29.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
29.41Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
29.41Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
29.41Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
29.41Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
29.41Consensuss1p_offOrthosteric Ligands1p1_off
29.41Consensussensory_offOrthosteric Ligandopsin_off
29.17Consensusangiotensin_onOrthosteric Ligandat1_on
29.17Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
28.57Single3RFMCaffeine3RFM-A2A-Caffeine
28.57Single6K1QIRL25006K1Q-ETB-IRL2500
28.57Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
28.57Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
28.57Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
28.57Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8A2OTheophylline8A2O-A2A-Theophylline-Na
28.57Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
28.57Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
28.57Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
28.57Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
28.57Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
28.57Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
28.57Consensussensory_onOrthosteric Ligandopsin_on
28.57Consensussteroid_onOrthosteric Ligandbileacid_on
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
28.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
28.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
28.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
27.78Single3EMLZM2413853EML-A2A-ZM241385
27.78Single4EIYZM2413854EIY-A2A-ZM241385-Na
27.78Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
27.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.78Single5K2AZM2413855K2A-A2A-ZM241385-Na
27.78Single5OLGZM2413855OLG-A2A-ZM241385-Na
27.78Single5UENDU1725UEN-A1-DU172
27.78Single5VRAZM2413855VRA-A2A-ZM241385-Na
27.78Single6LPJZM2413856LPJ-A2A-ZM241385-Na
27.78Single6LPKZM2413856LPK-A2A-ZM241385-Na
27.78Single6S0LZM2413856S0L-A2A-ZM241385
27.78Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
27.78Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
27.78Single7PYRPSB-21157PYR-A2A-PSB-2115
27.78Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
27.78Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.78Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
27.78Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
27.78Consensusa2_offOrthosteric Liganda2a_off
27.78Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
27.78Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
27.78Consensusgi_hcarOrthosteric Ligandgi_hca
27.78Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
27.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.78Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
27.59Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
27.59Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
27.59Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
27.27Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
27.27Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
27.27Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
27.27Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
27.27Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.92Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
26.92Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
26.92Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
26.67Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
26.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
26.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
26.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
26.67Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
26.67Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
26.67Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.67Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.32Single4NTJAZD12834NTJ-P2Y12-AZD1283
26.32Single5CGCHTL142425CGC-mGlu5-HTL14242
26.32Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.32Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
26.32Single5N2SPSB365N2S-A1-PSB36
26.32Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.32Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.32Single6LPLZM2413856LPL-A2A-ZM241385-Na
26.32Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.32Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
26.32Single6S0QZM2413856S0Q-A2A-ZM241385
26.32Single6WQAZM2413856WQA-A2A-ZM241385-Na
26.32Single7C4SS1P7C4S-S1P3-S1P
26.32Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7RM5ZM2413857RM5-A2A-ZM241385-Na
26.32Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
26.32Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single8FYNZM2413858FYN-A2A-ZM241385-Na
26.32Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.32Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
26.32Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
26.32Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
26.32Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single8QOTNanobody E8QOT-μ-Nanobody E
26.32Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.32Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.32Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.32Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
26.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.09Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7F8XNN90567F8X-CCKA-NN9056
26.09Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.09Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
26.09Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
26.09Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
26.09Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
26.09Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.93Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.93Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
25.81Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
25.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
25.00Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
25.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
25.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
25.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
25.00Single5XRAAM115425XRA-CB1-AM11542
25.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
25.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
25.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
25.00Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
25.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
25.00Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
25.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
25.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
25.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
25.00Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Consensusgo_class-b1Orthosteric Ligandgo_crf
25.00Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
25.00Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
25.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
25.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
25.00Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
24.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
24.14Single6IGLIRL16206IGL-ETB-IRL1620
24.14Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
24.14Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
24.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
24.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
24.14Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
24.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
24.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
24.00Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
23.81Single6ZG4HTL00099366ZG4-M1-HTL0009936
23.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.81Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.81Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
23.81Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
23.81Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
23.81Consensusdp_offOrthosteric Liganddp2_off
23.81Consensusgi_class-fOther Ligandgi_frizzled
23.81Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
23.81Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
23.81Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.81Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
23.81Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
23.53Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
23.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
23.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
23.53Single3PWHZM2413853PWH-A2A-ZM241385
23.53Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
23.53Single4S0VSuvorexant4S0V-OX2-Suvorexant
23.53Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.53Single6TPJSuvorexant6TPJ-OX2-Suvorexant
23.53Single7BR3Elagolix7BR3-GnRH1-Elagolix
23.53Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
23.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
23.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
23.53Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
23.53Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
23.53Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
23.53Single8IHKAcifran8IHK-HCA3-Acifran
23.53Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
23.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
23.53Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
23.53Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
23.53Consensusgt_class-aOrthosteric Ligandgt_opsin
23.53Consensusgt_opsinOrthosteric Ligandgt_sensory
23.53Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.33Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
23.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.08Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.08Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
23.08Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
23.08Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
22.73Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
22.73Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
22.73Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.73Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
22.73Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
22.73Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.58Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
22.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.58Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.22Single5UVIZM2413855UVI-A2A-ZM241385
22.22Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
22.22Single6MH8ZM2413856MH8-A2A-ZM241385
22.22Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
22.22Single6TPKRetosiban6TPK-OT-Retosiban
22.22Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
22.22Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
22.22Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
22.22Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
22.22Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
22.22Single8K5CAcipimox8K5C-HCA2-Acipimox
22.22Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
22.22Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
22.22Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusgnrh_offOrthosteric Ligandgnrh1_off
22.22Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Consensushca_onOrthosteric Ligandhca2_on hca3_on
22.22Consensushcar_onOrthosteric Ligandhca_on
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.22Consensusvasopressin-ot_offOrthosteric Ligandot_off
21.74Single5EE7MK08935EE7-Glucagon-MK0893
21.74Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.74Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
21.74Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
21.74Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
21.74Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
21.74Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
21.74Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
21.74Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
21.74Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
21.74Consensusclass-d_offOrthosteric Ligandste2_off
21.74Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.74Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
21.43Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
21.43Consensusclass-c_onOther Ligandgabab_on mglu_on
21.43Consensusclass-d_onOrthosteric Ligandste2_on
21.43Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.43Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
21.21Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
21.05Single4YAYZD-71554YAY-AT1-ZD-7155
21.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.05Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
21.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
21.05Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
21.05Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
21.05Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
21.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
21.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
21.05Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
21.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
21.05Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
21.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.05Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
21.05Single8K5DGSK2560738K5D-HCA2-GSK256073
21.05Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
21.05Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
21.05Consensusblt_onOrthosteric Ligandblt1_on
21.05Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
21.05Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.05Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
21.05Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
21.05Consensusleuko_onOrthosteric Ligandblt_on
21.05Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
20.83Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
20.83Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.83Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
20.83Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.83Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.69Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.69Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.69Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.69Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.69Consensusgi_class-dOrthosteric Ligandgi_ste
20.69Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
20.59Consensuspth_onOrthosteric Ligandpth1_on pth2_on
20.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.00Single6LMLGlucagon6LML-Glucagon-Glucagon
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
20.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.00Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
20.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
19.44Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
19.44Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
19.35Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
19.35Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.23Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
19.23Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
19.23Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
19.23Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
19.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
19.05Single7P2L4YI7P2L-mGlu5-4YI
19.05Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
19.05Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
19.05Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
19.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
19.05Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
19.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
19.05Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
19.05Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
19.05Consensuschemerin_onOrthosteric Ligandcml1_on
19.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.05Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.75Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
18.75Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
18.75Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
18.75Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
18.75Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
18.75Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
18.75Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
18.75Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
18.52Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.52Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.52Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.52Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
18.42Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
18.18Single4N4WSANT-14N4W-SMO-SANT-1
18.18Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
18.18Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
18.18Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.18Single7K15MKD0467K15-BLT1-MKD046-Na
18.18Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
18.18Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
18.18Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
18.18Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
18.18Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.18Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
18.18Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
18.18Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
18.18Consensusblt_offOrthosteric Ligandblt1_off
18.18Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
18.18Consensusclass-b2_onOrthosteric Ligandadgrg_on
17.95Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
17.86Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
17.86Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
17.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.86Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
17.86Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single3OE9IT1t3OE9-CXCR4-IT1t
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.65Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
17.65Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
17.65Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
17.65Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.65Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.39Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
17.39Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.39Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
17.39Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
17.39Consensuscyslt_offOrthosteric Ligandcyslt2_off
17.39Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single6FJ3PTH6FJ3-PTH1-PTH
17.24Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
17.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
17.24Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.24Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
17.14Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
17.14Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
16.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
16.67Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
16.67Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
16.67Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
16.67Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
16.67Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.67Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.13Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
16.13Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.13Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.13Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
16.13Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.13Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.13Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.00Single4XT1Fractalkine4XT1-US28-Fractalkine
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
16.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.79Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.79Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.79Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
15.79Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.79Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
15.79Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
15.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.38Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
15.38Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
15.38Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
15.38Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
15.38Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.38Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
15.15Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.15Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single5TGZAM65385TGZ-CB1-AM6538
15.00Single6GPSMK08126GPS-CCR2-MK0812
15.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
15.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
14.81Single3OE0CVX153OE0-CXCR4-CVX15
14.81Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
14.81Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.81Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
14.81Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
14.29Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
14.29Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
14.29Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.29Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
14.29Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
14.29Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.79Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.79Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
13.79Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
13.79Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
13.79Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
13.79Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
13.64Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
13.64Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.64Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.64Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
13.64Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.33Single4XT3Fractalkine4XT3-US28-Fractalkine
13.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.33Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.33Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
13.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.33Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
13.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.33Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.04Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.04Single4PY02MeSATP4PY0-P2Y12-2MeSATP
13.04Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.04Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
13.04Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
13.04Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
13.04Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
12.90Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.90Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.50Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
12.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.50Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
12.50Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
12.50Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
12.50Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
12.50Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
12.50Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
12.00Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.76Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.76Single3OE6IT1t3OE6-CXCR4-IT1t
11.76Single3OE8IT1t3OE8-CXCR4-IT1t
11.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.76Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
11.54Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
11.54Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.54Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
11.54Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.43Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.43Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
11.11Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.11Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.11Single7SK5CXCL127SK5-ACKR3-CXCL12
11.11Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
11.11Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusclass-t_onOrthosteric Ligandtaste2_on
11.11Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.11Consensusgs_class-tOrthosteric Ligandgs_taste
11.11Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11Consensussst_offOrthosteric Ligandsst2_off
11.11Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.81Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.71Single7XNACYN1548067XNA-SST2-CYN154806
10.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.71Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.53Single3ODUIT1t3ODU-CXCR4-IT1t
10.53Single5U09Taranabant5U09-CB1-Taranabant
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.53Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.53Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.53Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.34Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.34Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.34Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.34Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.26Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
10.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
9.68Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
9.68Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.68Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
9.52Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.52Single6FFHFenobam6FFH-mGlu5-Fenobam
9.52Single6IIVDaltroban6IIV-TP-Daltroban
9.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
9.52Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Consensushcar_offOrthosteric Ligandsuccinate_off
9.52Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
9.52Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
9.52Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.52Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
9.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
9.38Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
9.09Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.09Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
9.09Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.09Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.09Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.09Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.09Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.09Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
9.09Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.09Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
9.09Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
9.09Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.09Consensusep_offOrthosteric Ligandep4_off
9.09Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
8.82Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single5TZR-5TZR-FFA1 (GPR40)-MK8666
8.70Single5V56TC1145V56-SMO-TC114
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.70Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
8.70Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single5X33BIIL2605X33-BLT1-BIIL260
8.33Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
8.33Single6IIURamatroban6IIU-TP-Ramatroban
8.33Single6OS2TRV0266OS2-AT1-TRV026
8.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
8.33Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Consensuschemokine_offOrthosteric Ligandcxcr_off
8.33Consensusclass-c_offOther Ligandgabab_off mglu_off
8.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
8.33Consensuscxcr_offOrthosteric Ligandcxcr4_off
8.33Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
8.33Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.33Consensusnts_offOrthosteric Ligandnts1_off
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.00Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.69Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.41Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
7.41Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
7.32Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
6.67Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.45Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.25Single7SK3CXCL127SK3-ACKR3-CXCL12
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.25Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.06Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.06Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.06Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
5.88Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.88Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.88Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.88Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
5.71Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
5.71Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.56Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.56Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.41Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.26Single5L7IVismodegib5L7I-SMO-Vismodegib
5.26Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.26Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.26Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.76Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.76Single7VV6C48/807VV6-MRGPRX2-C48/80
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Single8K2WAMG4878K2W-CXCR3-AMG487
4.76Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.76Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.65Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.55Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.35Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.35Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.35Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.17Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.17Single5V57TC1145V57-SMO-TC114
4.17Single6OS1TRV0266OS1-AT1-TRV026
4.17Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Consensusnts_onOrthosteric Ligandnts1_on
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.85Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.85Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.85Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.85Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.57Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.86Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.78Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.70Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.63Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.44Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.27Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 5TVN
Class A
SubFamily Amine
Type 5-Hydroxytryptamine
SubType 5-HT2B
Species Homo sapiens
Ligand LSD
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.9
Date 2017-02-01
D.O.I. 10.1016/j.cell.2016.12.033
Net Summary
Imin 3.2
Number of Linked Nodes 277
Number of Links 311
Number of Hubs 38
Number of Links mediated by Hubs 160
Number of Communities 6
Number of Nodes involved in Communities 66
Number of Links involved in Communities 96
Path Summary
Number Of Nodes in MetaPath 74
Number Of Links MetaPath 73
Number of Shortest Paths 58149
Length Of Smallest Path 3
Average Path Length 11.8808
Length of Longest Path 22
Minimum Path Strength 1.405
Average Path Strength 6.49394
Maximum Path Strength 23.51
Minimum Path Correlation 0.7
Average Path Correlation 0.956159
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 7.14286
Average % Of Corr. Nodes 71.3302
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.1544
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code7LD
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code7LD
NameLysergic acid diethylamide
SynonymsD-lysergic acid diethylamide
Identifier(6~{a}~{R},9~{R})-~{N},~{N}-diethyl-7-methyl-6,6~{a},8,9-tetrahydro-4~{H}-indolo[4,3-fg]quinoline-9-carboxamide
FormulaC20 H25 N3 O
Molecular Weight323.432
SMILESCCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4c3c(ccc4)C2=C1)C
PubChem5761
Formal Charge0
Total Atoms49
Total Chiral Atoms2
Total Bonds52
Total Aromatic Bonds10

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP41595
Sequence
>5TVN_Chain_R
EEMKQIVEE QGNKLHWAA LLILMVIIP TIGGNTLVI LAVSLEKKL 
QYATNYFLM SLAVADLLV GLFVMPIAL LTIMFEAMW PLPLVLCPA 
WLFLDVLFS TASIWHLCA ISVDRYIAI KKPIQANQY NSRATAFIK 
ITVVWLISI GIAIPVPIK GIETNPNNI TCVLTKERF GDFMLFGSL 
AAFFTPLAI MIVTYFLTI HALQKKAVQ TISNEQRAS KVLGIVFFL 
FLLMWCPFF ITNITLVLC DSCNQTTLQ MLLEIFVWI GYVSSGVNP 
LVYTLFNKT FRDAFGRYI TCNYR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4IB4AAmine5-Hydroxytryptamine5-HT2BHomo sapiensErgotamine--2.72013-03-1310.1126/science.1232808
4NC3AAmine5-Hydroxytryptamine5-HT2BHomo sapiensErgotamine--2.82013-12-1810.1126/science.1244142
5TUDAAmine5-Hydroxytryptamine5-HT2BHomo sapiensErgotamine--32017-07-2610.1073/pnas.1700891114
6DRXAAmine5-Hydroxytryptamine5-HT2BHomo sapiensLisuride--3.12018-08-2910.1038/s41594-018-0116-7
6DRYAAmine5-Hydroxytryptamine5-HT2BHomo sapiensMethylergonovine--2.922018-08-2910.1038/s41594-018-0116-7
6DRZAAmine5-Hydroxytryptamine5-HT2BHomo sapiensMethysergide--3.12018-08-2910.1038/s41594-018-0116-7
6DS0AAmine5-Hydroxytryptamine5-HT2BHomo sapiensLy266097--3.192018-08-2910.1038/s41594-018-0116-7
7SRQAAmine5-Hydroxytryptamine5-HT2BHomo sapiensLSD--2.72022-09-2110.1016/j.neuron.2022.08.006
7SRRAAmine5-Hydroxytryptamine5-HT2BHomo sapiensLSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;22.92022-09-2110.1016/j.neuron.2022.08.006
7SRSAAmine5-Hydroxytryptamine5-HT2BHomo sapiensLSD-Arrestin23.32022-09-2110.1016/j.neuron.2022.08.006




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