Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y24 8.41254192
2R:R:I40 3.315406
3R:R:N43 6.28409
4R:R:V49 4.075408
5R:R:V50 3.06254208
6R:R:T58 4.5575407
7R:R:T60 5.65529
8R:R:Y63 7.535608
9R:R:L64 4.944528
10R:R:L67 4.5825429
11R:R:D71 6.132529
12R:R:L75 3.04407
13R:R:I83 3.6225406
14R:R:W91 6.72167618
15R:R:Y93 6.606506
16R:R:Y95 4.975413
17R:R:C98 4.4375419
18R:R:T102 6.58414
19R:R:Y103 7.00754216
20R:R:Q105 6.77167617
21R:R:Y106 10.0143715
22R:R:L107 4.8285215
23R:R:I109 3.854517
24R:R:N110 7.384516
25R:R:F119 8.022529
26R:R:E122 7.935428
27R:R:R123 9.0275429
28R:R:Y124 8.744228
29R:R:I127 5.07429
30R:R:C128 3.6054227
31R:R:I131 4.07754127
32R:R:C137 2.675427
33R:R:W160 10.91515
34R:R:F161 5.1405
35R:R:L164 6.77415
36R:R:L166 3.5325414
37R:R:Y171 4.4425401
38R:R:Y181 8.56167614
39R:R:R185 10.075412
40R:R:Y188 7.502515
41R:R:Y192 5.95143715
42R:R:F196 3.672506
43R:R:F199 8.04333615
44R:R:Y200 4.715408
45R:R:Y211 8.725409
46R:R:I214 4.41409
47R:R:L218 3.9725408
48R:R:W279 7.395408
49R:R:Y282 6.52615
50R:R:R283 5.766516
51R:R:L285 4.075414
52R:R:N289 5.67514
53R:R:L302 3.3725404
54R:R:C305 3.105415
55R:R:Y310 6.74517
56R:R:N316 5.066529
57R:R:I319 2.956528
58R:R:Y320 4.26143729
59R:R:F327 8.4725428
60A:A:L30 2.835485
61A:A:L41 6.3175406
62A:A:L45 6.234598
63A:A:S51 3409
64A:A:K53 6.865499
65A:A:F56 6.544597
66A:A:I57 6.8025497
67A:A:F212 7.5175409
68A:A:F219 6.901676128
69A:A:H220 12.1525457
70A:A:M221 4.764598
71A:A:F222 9.93557
72A:A:Q227 4.354259
73A:A:R232 5.056558
74A:A:W234 7.196559
75A:A:I235 4.56459
76A:A:Q236 4.3775438
77A:A:F238 8.67559
78A:A:I244 3.285458
79A:A:I245 3.1025497
80A:A:D252 6.094178
81A:A:R265 6.534179
82A:A:L270 5.47406
83A:A:F273 5.4675409
84A:A:W277 11.06406
85A:A:W281 7.326535
86A:A:L282 5.27459
87A:A:I285 3.635457
88A:A:L289 3.92409
89A:A:F290 5.16699
90A:A:I308 6.98467
91A:A:F315 11.4375466
92A:A:Y318 5.368566
93A:A:E330 7.536563
94A:A:V334 4.236564
95A:A:K338 9.16465
96A:A:Y339 5.6675463
97A:A:F340 6.30333667
98A:A:F345 8.6425408
99A:A:Y360 6.9185278
100A:A:F363 8.705465
101A:A:T364 6.0325499
102A:A:N371 5.9825499
103A:A:F376 6.482867128
104A:A:L388 3.74833628
105A:A:Y391 6.432524
106A:A:L393 5.175428
107B:B:I18 3.3625407
108B:B:D27 6.085408
109B:B:I37 3.5325402
110B:B:V40 4.625153
111B:B:H54 9.53167689
112B:B:Y59 7.4575438
113B:B:W63 6.246137
114B:B:D76 5.335489
115B:B:I80 10.5425488
116B:B:I81 4.64754117
117B:B:W82 12.298589
118B:B:N88 6.29407
119B:B:K89 6.20571789
120B:B:H91 5.94115
121B:B:I93 6.24117
122B:B:L95 4.5565118
123B:B:W99 8.295659
124B:B:Y105 4.86667606
125B:B:N110 6.124184
126B:B:Y111 5.544184
127B:B:L117 3.71459
128B:B:C121 4.135478
129B:B:I123 5.355406
130B:B:Y124 4.455717116
131B:B:T128 4.26754283
132B:B:E130 4.954283
133B:B:V133 6.52254114
134B:B:H142 6.16667679
135B:B:Y145 6.33333608
136B:B:L146 3.9175477
137B:B:C149 3.8275478
138B:B:F151 5.082509
139B:B:L152 3.525403
140B:B:I157 5.38477
141B:B:T159 5.12833679
142B:B:D163 8.1275479
143B:B:T165 4.785477
144B:B:C166 4.0525448
145B:B:L168 4.285446
146B:B:W169 6.16429778
147B:B:F180 7.242547
148B:B:H183 8.32333649
149B:B:V187 4.684549
150B:B:V200 5.714296
151B:B:S201 5.6125449
152B:B:C204 5.19407
153B:B:D205 7.7475449
154B:B:K209 9.05446
155B:B:L210 4.83405
156B:B:W211 9.486548
157B:B:C218 5.4575445
158B:B:Q220 8.02254107
159B:B:F222 9.94254108
160B:B:H225 10.41176109
161B:B:I232 5.0975408
162B:B:F235 6.75167636
163B:B:P236 5.3075437
164B:B:N237 9.13435
165B:B:F241 7.5754106
166B:B:D247 8.53754109
167B:B:R251 10.3085108
168B:B:F253 8.52754106
169B:B:D258 8.34107
170B:B:M262 4.884534
171B:B:Y264 6.03535
172B:B:I269 3.6175434
173B:B:C271 3.83435
174B:B:F278 5.316537
175B:B:R283 8.3185159
176B:B:L284 3.7885155
177B:B:Y289 7.13429737
178B:B:D290 4.7025436
179B:B:N295 6.376536
180B:B:V296 4.2875405
181B:B:W297 6.4725438
182B:B:K301 4.7725405
183B:B:H311 8.3465149
184B:B:R314 9.412538
185B:B:W332 11.1729739
186B:B:D333 7.55254149
187B:B:K337 6.884146
188B:B:W339 11.45754149
189G:G:L19 4.19409
190G:G:R27 4.37508
191G:G:D48 5.77167609
192G:G:P49 3.8525407
193G:G:L51 4.5885156
194G:G:N59 6.165409
195G:G:P60 5.97254169
196G:G:F61 5.256168
197L:L:?1 6.5241010
198L:L:H2 6.58714710
199L:L:P3 8.37714710
200L:L:?4 8.73410
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L104 R:R:Y103 20.96623.52NoYes046
2R:R:A77 R:R:L104 39.46073.15NoNo054
3R:R:A77 R:R:V76 36.99451.7NoNo054
4R:R:L80 R:R:V76 34.52832.98NoNo084
5R:R:I83 R:R:L80 32.06212.85YesNo068
6R:R:I29 R:R:I83 24.66334.42NoYes056
7R:R:I29 R:R:S86 22.1976.19NoNo054
8R:R:Q25 R:R:S86 19.73084.33NoNo044
9R:R:Q25 R:R:V20 12.33185.73NoNo043
10R:R:L166 R:R:W91 11.7283.42YesYes148
11R:R:I101 R:R:W91 18.50373.52NoYes058
12R:R:I101 R:R:Q105 19.12044.12NoYes057
13L:L:P3 R:R:Q105 22.199512.63YesYes107
14L:L:P3 R:R:I109 51.17383.39YesYes107
15R:R:I109 R:R:W279 1003.52YesYes078
16R:R:N312 R:R:W279 1009.04NoYes098
17R:R:N312 R:R:N316 1006.81NoYes099
18R:R:L64 R:R:Y320 1004.69YesYes289
19R:R:N316 R:R:Y320 1003.49YesYes299
20R:R:L64 R:R:T60 1002.95YesYes289
21R:R:F119 R:R:Y320 1004.13YesYes299
22R:R:F119 R:R:T60 1007.78YesYes299
23B:B:L318 B:B:S275 55.37239.01NoNo068
24B:B:S275 B:B:T274 55.53783.2NoNo088
25B:B:R314 B:B:T274 55.6949.06YesNo388
26A:A:Q236 B:B:R314 44.63584.67YesYes388
27A:A:K233 A:A:Q236 70.87284.07NoYes098
28A:A:K233 B:B:M188 71.08194.32NoNo098
29B:B:M188 B:B:Y145 71.43754.79NoYes088
30A:A:W234 B:B:Y145 81.1695.79YesYes098
31A:A:R232 A:A:W234 1008YesYes589
32A:A:I276 A:A:R232 1005.01NoYes588
33A:A:F246 A:A:I276 1003.77NoNo098
34A:A:F246 A:A:L289 1003.65NoYes099
35A:A:L289 A:A:L291 1002.77YesNo098
36A:A:I341 A:A:L291 1002.85NoNo088
37A:A:I308 A:A:I341 1002.94YesNo078
38A:A:I308 A:A:Y253 10012.09YesNo078
39A:A:Y253 A:A:Y311 10010.92NoNo086
40A:A:N264 A:A:Y311 10011.63NoNo096
41A:A:D252 A:A:N264 1002.69YesNo089
42A:A:D249 A:A:D252 1005.32NoYes1788
43A:A:D249 A:A:K293 10011.06NoNo089
44A:A:K293 A:A:N292 1006.99NoNo099
45A:A:N292 A:A:V247 46.09692.96NoNo097
46A:A:K53 A:A:V247 92.14573.04YesNo097
47A:A:K53 A:A:L45 1009.87YesYes998
48A:A:L45 A:A:M221 69.01117.07YesYes988
49A:A:L43 A:A:M221 91.84492.83NoYes078
50A:A:F219 A:A:L43 1006.09YesNo087
51A:A:F219 A:A:L41 1006.09YesYes086
52A:A:L41 R:R:Q134 1003.99YesNo066
53A:A:I383 R:R:Q134 1008.23NoNo086
54A:A:I383 A:A:N387 1004.25NoNo088
55A:A:N387 A:A:Y391 1006.98NoYes284
56A:A:Y391 R:R:T60 1009.99YesYes249
57B:B:R314 B:B:W332 89.512421.99YesYes389
58B:B:W332 B:B:Y59 10014.47YesYes398
59A:A:C237 B:B:Y59 1002.69NoYes088
60A:A:C237 A:A:F238 1004.19NoYes089
61A:A:F238 A:A:W234 83.82814.01YesYes599
62A:A:F238 A:A:L44 84.178815.83YesNo099
63A:A:L44 A:A:L46 84.05434.15NoNo098
64A:A:I276 A:A:L46 84.09982.85NoNo588
65A:A:D252 A:A:R265 92.21975.96YesYes1789
66A:A:R265 A:A:T48 92.22373.88YesNo098
67A:A:S51 A:A:T48 92.20823.2YesNo098
68A:A:S51 A:A:V247 46.0973.23YesNo097
69A:A:G47 A:A:S51 46.09593.71NoYes099
70A:A:G47 A:A:K53 46.07823.49NoYes099
71A:A:N292 A:A:T364 1002.92NoYes099
72A:A:F290 A:A:T364 1005.19YesYes999
73A:A:F290 A:A:F56 69.47765.36YesYes997
74A:A:F56 A:A:M221 23.15444.98YesYes978
75A:A:I245 A:A:L45 68.84352.85YesYes978
76A:A:I245 A:A:L43 1002.85YesNo077
77A:A:F56 A:A:I245 23.09843.77YesYes977
78A:A:F290 A:A:I375 46.32715.02YesNo099
79A:A:I245 A:A:I375 23.09852.94YesNo079
80A:A:F56 A:A:I57 23.211211.3YesYes977
81A:A:F212 A:A:I57 46.371210.05YesYes097
82A:A:F212 A:A:F219 46.114116.08YesYes098
83A:A:I375 A:A:I57 23.21062.94NoYes097
84R:R:L104 R:R:M73 20.96172.83NoNo046
85R:R:L107 R:R:Y103 27.12634.69YesYes2156
86R:R:L107 R:R:M73 23.42765.65YesNo056
87L:L:?1 L:L:P3 11.7183.5YesYes100
88R:R:L107 R:R:T153 54.25122.95YesNo058
89R:R:I109 R:R:N110 28.38885.66YesYes176
90R:R:N110 R:R:R283 28.3523.62YesYes166
91R:R:R283 R:R:W279 41.28597YesYes068
92R:R:C128 R:R:I214 12.09021.64YesYes079
93A:A:L393 R:R:R123 16.117610.93YesYes289
94R:R:G180 R:R:Y181 12.33272.9NoYes034
95B:B:M61 B:B:W63 17.74883.49NoYes1367
96B:B:C317 B:B:M61 17.9714.86NoNo076
97B:B:C317 B:B:S316 18.08143.44NoNo079
98B:B:S316 B:B:W332 18.19214.94NoYes099
99A:A:Q236 A:A:W281 26.16945.48YesYes385
100A:A:W281 B:B:W332 52.45774.69YesYes359
101A:A:W281 B:B:D290 78.31094.47YesYes356
102B:B:D290 B:B:R314 78.2938.34YesYes368
103B:B:L7 G:G:R13 11.6242.43NoNo086
104B:B:L7 G:G:V16 15.49862.98NoNo087
105B:B:E10 G:G:V16 19.37325.7NoNo087
106B:B:E10 G:G:K20 21.31042.7NoNo086
107B:B:L14 G:G:K20 25.18494.23NoNo086
108B:B:L14 G:G:L19 29.05935.54NoYes089
109B:B:I18 G:G:L19 36.8081.43YesYes079
110B:B:I18 B:B:R22 48.42025.01YesNo076
111B:B:Q259 B:B:R22 1005.84NoNo066
112B:B:Q259 G:G:V30 1004.3NoNo068
113B:B:D27 G:G:V30 1002.92YesNo088
114B:B:D27 G:G:S31 1005.89YesNo089
115B:B:I33 G:G:S31 1003.1NoNo039
116B:B:I33 G:G:M38 1002.92NoNo034
117B:B:I37 G:G:M38 1002.92YesNo024
118B:B:I37 B:B:R283 1003.76YesYes029
119B:B:R283 B:B:V40 78.77366.54YesYes1593
120B:B:L284 B:B:V40 85.40712.98YesYes1553
121B:B:I43 B:B:L284 33.68332.85NoYes035
122B:B:I43 B:B:M45 34.01224.37NoNo034
123B:B:L308 B:B:M45 51.77892.83NoNo074
124B:B:C294 B:B:L308 51.88013.17NoNo057
125B:B:C294 B:B:L318 52.20794.76NoNo056
126B:B:R283 G:G:L51 1006.07YesYes1596
127B:B:L284 G:G:L51 81.28194.15YesYes1556
128G:G:D48 G:G:L51 27.28616.79YesYes096
129G:G:D48 G:G:L50 16.95232.71YesNo099
130B:B:M45 G:G:L50 17.60815.65NoNo049
131B:B:L284 B:B:V296 1005.96YesYes055
132B:B:G306 B:B:V296 1001.84NoYes045
133B:B:G306 B:B:V307 1001.84NoNo043
134B:B:N293 B:B:V307 68.95754.43NoNo053
135B:B:D291 B:B:N293 69.95285.39NoNo085
136B:B:C271 B:B:D291 70.28496.22YesNo358
137B:B:C271 B:B:D290 1003.11YesYes356
138B:B:N295 B:B:V307 69.04084.43YesNo063
139B:B:N295 B:B:Y289 69.629612.79YesYes367
140B:B:C271 B:B:Y289 85.33124.03YesYes357
141G:G:D48 G:G:P49 11.5213.22YesYes097
142B:B:M325 G:G:P49 12.18418.39NoYes057
143B:B:D323 B:B:M325 12.0958.32NoNo075
144B:B:D323 B:B:T321 12.2017.23NoNo1377
145B:B:T321 B:B:W63 12.423910.92NoYes1377
146B:B:D258 B:B:R22 10011.91YesNo076
147B:B:W297 B:B:Y264 10.75994.82YesYes385
148B:B:W297 B:B:Y289 11.36838.68YesYes387
149B:B:D258 B:B:F222 58.10544.78YesYes1078
150B:B:L210 B:B:V200 17.43382.98YesYes056
151B:B:L210 B:B:Q220 29.05556.65YesYes057
152B:B:D258 B:B:Q220 32.926111.75YesYes1077
153B:B:F234 B:B:V200 13.560910.49NoYes2956
154B:B:A193 B:B:F234 11.62374.16NoNo045
155B:B:H225 B:B:T243 13.55979.58YesNo098
156B:B:F253 B:B:T243 15.49565.19YesNo068
157B:B:F222 B:B:F253 48.421913.93YesYes1086
158B:B:H225 B:B:R251 13.558919.18YesYes1098
159B:B:F253 B:B:R251 30.99135.34YesYes1068
160R:R:N110 R:R:T153 55.4842.92YesNo068
161L:L:?1 R:R:Y106 11.71543.74YesYes105
162R:R:I109 R:R:Y106 42.54633.63YesYes175
163R:R:D71 R:R:N316 16.01558.08YesYes299
164R:R:I319 R:R:Y320 10.476.04YesYes289
165R:R:F119 R:R:R123 22.164912.83YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I109 R:R:V74 3.07 1 Yes No 7 7 1 2
R:R:A78 R:R:Q105 4.55 1 No Yes 7 7 1 1
L:L:?4 R:R:A78 3.93 1 Yes No 0 7 0 1
R:R:G79 R:R:N82 3.39 1 No No 7 6 2 2
R:R:G79 R:R:Y310 5.79 1 No Yes 7 7 2 1
R:R:N82 R:R:R306 3.62 1 No No 6 5 2 2
R:R:N82 R:R:Y310 8.14 1 No Yes 6 7 2 1
R:R:C98 R:R:T102 3.38 1 Yes Yes 9 4 2 1
R:R:C98 R:R:L164 3.17 1 Yes Yes 9 5 2 1
R:R:I101 R:R:Q105 4.12 0 No Yes 5 7 2 1
R:R:Q105 R:R:T102 5.67 1 Yes Yes 7 4 1 1
R:R:L164 R:R:T102 11.79 1 Yes Yes 5 4 1 1
L:L:H2 R:R:T102 5.48 1 Yes Yes 0 4 0 1
L:L:H2 R:R:Q105 3.71 1 Yes Yes 0 7 0 1
L:L:P3 R:R:Q105 12.63 1 Yes Yes 0 7 0 1
L:L:?4 R:R:Q105 9.95 1 Yes Yes 0 7 0 1
R:R:I109 R:R:Y106 3.63 1 Yes Yes 7 5 1 1
R:R:W160 R:R:Y106 33.76 1 Yes Yes 5 5 2 1
R:R:Y106 R:R:Y192 3.97 1 Yes Yes 5 5 1 1
R:R:Y106 R:R:Y282 2.98 1 Yes Yes 5 5 1 1
L:L:?1 R:R:Y106 3.74 1 Yes Yes 0 5 0 1
L:L:H2 R:R:Y106 10.89 1 Yes Yes 0 5 0 1
L:L:P3 R:R:Y106 11.13 1 Yes Yes 0 5 0 1
R:R:I109 R:R:N110 5.66 1 Yes Yes 7 6 1 2
R:R:I109 R:R:W279 3.52 1 Yes Yes 7 8 1 2
L:L:P3 R:R:I109 3.39 1 Yes Yes 0 7 0 1
R:R:L164 R:R:W160 5.69 1 Yes Yes 5 5 1 2
R:R:W160 R:R:Y188 3.86 1 Yes Yes 5 5 2 2
R:R:W160 R:R:Y192 7.72 1 Yes Yes 5 5 2 1
L:L:H2 R:R:L164 6.43 1 Yes Yes 0 5 0 1
R:R:G180 R:R:Y181 2.9 0 No Yes 3 4 2 1
R:R:R185 R:R:Y181 15.43 1 Yes Yes 2 4 1 1
R:R:Y181 R:R:Y188 12.91 1 Yes Yes 4 5 1 2
R:R:Y181 R:R:Y192 5.96 1 Yes Yes 4 5 1 1
L:L:?1 R:R:Y181 8.73 1 Yes Yes 0 4 0 1
L:L:H2 R:R:Y181 5.44 1 Yes Yes 0 4 0 1
R:R:R185 R:R:Y192 7.2 1 Yes Yes 2 5 1 1
R:R:N289 R:R:R185 6.03 1 Yes Yes 4 2 1 1
L:L:?1 R:R:R185 11.64 1 Yes Yes 0 2 0 1
R:R:Y188 R:R:Y192 2.98 1 Yes Yes 5 5 2 1
R:R:V286 R:R:Y192 10.09 1 No Yes 6 5 1 1
L:L:?1 R:R:Y192 3.74 1 Yes Yes 0 5 0 1
R:R:V286 R:R:Y282 8.83 1 No Yes 6 5 1 1
R:R:C305 R:R:Y282 2.69 1 Yes Yes 5 5 2 1
R:R:I309 R:R:Y282 7.25 0 No Yes 6 5 2 1
L:L:?1 R:R:Y282 6.24 1 Yes Yes 0 5 0 1
L:L:P3 R:R:Y282 11.13 1 Yes Yes 0 5 0 1
R:R:L285 R:R:N289 5.49 1 Yes Yes 4 4 2 1
R:R:L285 R:R:L302 2.77 1 Yes Yes 4 4 2 1
R:R:C305 R:R:L285 3.17 1 Yes Yes 5 4 2 2
L:L:?1 R:R:V286 6.34 1 Yes No 0 6 0 1
R:R:N289 R:R:P295 8.15 1 Yes No 4 1 1 2
L:L:?1 R:R:N289 7.31 1 Yes Yes 0 4 0 1
R:R:L302 R:R:R306 3.64 0 Yes No 4 5 1 2
L:L:?1 R:R:L302 4.42 1 Yes Yes 0 4 0 1
R:R:R306 R:R:Y310 6.17 1 No Yes 5 7 2 1
R:R:I309 R:R:Y310 4.84 0 No Yes 6 7 2 1
L:L:?4 R:R:Y310 8.76 1 Yes Yes 0 7 0 1
R:R:L302 R:R:Q297 2.66 0 Yes No 4 3 1 2
R:R:L292 R:R:N289 1.37 0 No Yes 4 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
100.00Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
72.22Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
64.71Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.89Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.63Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
50.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
50.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.37Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
47.06Single6PS1Timolol6PS1-β2-Timolol
47.06Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
47.06Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
44.44Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
44.44Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
44.44Single6PS6Timolol6PS6-β2-Timolol
44.44Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
44.44Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
44.44Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
44.44Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
44.44Single7XKAEpinephrine7XKA-β2-Epinephrine
44.44Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
44.44Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
44.44Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
44.44Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
43.75Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
43.75Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
43.75Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
43.75Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
43.48Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
43.48Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
43.48Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
42.86Single7XN9L-054,5227XN9-SST2-L-054,522
42.86Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
42.86Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
42.86Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
42.11Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
42.11Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
42.11Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
42.11Single6H7JIsoprenaline6H7J-β1-Isoprenaline
42.11Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
42.11Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
42.11Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
42.11Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
42.11Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
42.11Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
42.11Single8E0GBU728E0G-μ-BU72
42.11Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
42.11Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
42.11Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
42.11Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
41.18Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
41.18Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
41.18Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
41.18Single6PS4ICI 118-5516PS4-β2-ICI 118-551
41.18Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GGQEpinephrine8GGQ-β2-Epinephrine
41.18Single8GGTEpinephrine8GGT-β2-Epinephrine
41.18Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
40.91Single4IARErgotamine4IAR-5-HT1B-Ergotamine
40.91Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
40.91Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.91Consensussst_onOrthosteric Ligandsst2_on sst4_on
40.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
40.00Single4LDEBI1671074LDE-β2-BI167107
40.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
40.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
40.00Single7YITNalfurafine7YIT-κ-Nalfurafine
40.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8JJ8Formoterol8JJ8-β2-Formoterol
40.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
40.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
39.13Single3QAKUK-4320973QAK-A2A-UK-432097
39.13Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
39.13Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
38.89Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
38.89Single2Y04Salbutamol2Y04-β1-Salbutamol
38.89Single3NY8ICI 118-5513NY8-β2-ICI 118-551
38.89Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
38.89Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
38.89Single4EJ4Naltrindole4EJ4-δ-Naltrindole
38.89Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
38.89Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
38.89Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
38.89Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
38.89Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
38.89Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
38.89Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
38.89Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
38.89Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
38.89Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
38.89Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
38.89Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
38.89Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8GGJEpinephrine8GGJ-β2-Epinephrine
38.89Single8GGNEpinephrine8GGN-β2-Epinephrine
38.89Single8GGOEpinephrine8GGO-β2-Epinephrine
38.89Single8GGUEpinephrine8GGU-β2-Epinephrine
38.89Single8JJOAlprenolol8JJO-β2-Alprenolol
38.89Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
38.89Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
38.89Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
38.89Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
38.89Consensusadenosine_onOrthosteric Liganda1_on a2_on
38.89Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
38.89Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
38.89Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
38.89Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
38.89Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.46Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
38.10Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
38.10Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
38.10Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.10Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.10Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.10Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
38.10Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.10Single7EZCUKA7EZC-A2A-UKA
38.10Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
38.10Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
38.10Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
37.50Single3PBLEticlopride3PBL-D3-Eticlopride
37.50Single5WF5UK-4320975WF5-A2A-UK-432097
37.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
37.50Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
37.50Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
37.50Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GH1Epinephrine8GH1-β2-Epinephrine
37.50Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
37.50Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
37.50Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
37.50Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
36.84Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
36.84Single2Y03Isoprenaline2Y03-β1-Isoprenaline
36.84Single5C1MBU725C1M-μ-BU72
36.84Single5TVNLSD5TVN-5-HT2B-LSD
36.84Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
36.84Single5XPRBosentan5XPR-ETB-Bosentan
36.84Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
36.84Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
36.84Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
36.84Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
36.84Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
36.84Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
36.84Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
36.84Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
36.84Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
36.84Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
36.84Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
36.84Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
36.84Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
36.84Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
36.84Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
36.84Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
36.84Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
36.84Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
36.84Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
36.84Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.36Single3NY9PubChem 9131033NY9-β2-PubChem 913103
36.36Single4UG2CGS216804UG2-A2A-CGS21680
36.36Single6PT3DPI-2876PT3-δ-DPI-287
36.36Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
36.36Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.29Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.29Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.29Single6TODEMPA6TOD-OX1-EMPA-Na
35.29Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
35.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
35.29Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
35.29Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
35.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
35.29Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
35.29Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8GGVEpinephrine8GGV-β2-Epinephrine
35.29Single8GGWEpinephrine8GGW-β2-Epinephrine
35.29Single8GGXEpinephrine8GGX-β2-Epinephrine
35.29Single8GH0Epinephrine8GH0-β2-Epinephrine
35.29Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8IWESpermidine8IWE-TAAR9-Spermidine
35.29Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
35.29Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
35.00Single2YDVNECA2YDV-A2A-NECA
35.00Single3P0GBI1671073P0G-β2-BI167107
35.00Single4DJHJDTic4DJH-κ-JDTic
35.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
35.00Single4UHRCGS216804UHR-A2A-CGS21680
35.00Single5G53NECA5G53-A2A-NECA-Gs
35.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
35.00Single6J20Aprepitant6J20-NK1-Aprepitant
35.00Single6J21Aprepitant6J21-NK1-Aprepitant
35.00Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
35.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
35.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
35.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
35.00Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
35.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
35.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
35.00Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
35.00Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
35.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
35.00Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
35.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
35.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
35.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
35.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
35.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
35.00Consensusa2_onOrthosteric Liganda2a_on a2b_on
35.00Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
35.00Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
35.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
35.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
35.00Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
35.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
34.78Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
34.78Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
34.78Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
34.78Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
34.78Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
34.78Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
34.78Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
34.78Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.62Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
34.48Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
33.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
33.33Single2YDOAdenosine2YDO-A2A-Adenosine
33.33Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
33.33Single4AMIBucindolol4AMI-β1-Bucindolol
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
33.33Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
33.33Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
33.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
33.33Single6TPGEMPA6TPG-OX2-EMPA
33.33Single6TPKRetosiban6TPK-OT-Retosiban
33.33Single6TPNHTL66416TPN-OX2-HTL6641
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6VI4JDTic6VI4-κ-JDTic
33.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
33.33Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
33.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
33.33Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
33.33Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
33.33Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
33.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
33.33Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8GGIEpinephrine8GGI-β2-Epinephrine
33.33Single8GGKEpinephrine8GGK-β2-Epinephrine
33.33Single8GGLEpinephrine8GGL-β2-Epinephrine
33.33Single8GGMEpinephrine8GGM-β2-Epinephrine
33.33Single8GGPEpinephrine8GGP-β2-Epinephrine
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
33.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
33.33Single8JJLOlodaterol8JJL-β2-Olodaterol
33.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
33.33Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
33.33Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
33.33Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
33.33Single8WU1KCA8WU1-CB1-KCA-Arrestin1
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
33.33Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
33.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
33.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
33.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
33.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
33.33Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
33.33Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
33.33Consensusvasopressin-ot_offOrthosteric Ligandot_off
32.14Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
32.00Single6PT2KGCHM076PT2-δ-KGCHM07
32.00Single6W25SHU91196W25-MC4-SHU9119-Ca
32.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
32.00Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
31.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
31.82Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
31.82Single6H7LDobutamine6H7L-β1-Dobutamine
31.82Single6IBLArformoterol6IBL-β1-Arformoterol
31.82Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
31.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
31.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
31.82Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
31.82Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
31.82Consensusendothelin_offOrthosteric Ligandetb_off
31.82Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
31.82Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.82Consensusorexin_onOrthosteric Ligandox2_on
31.58Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
31.58Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
31.58Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.58Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
31.58Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
31.58Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
31.58Single6DRXLisuride6DRX-5-HT2B-Lisuride
31.58Single6H7MSalbutamol6H7M-β1-Salbutamol
31.58Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
31.58Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
31.58Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single7BU7BI1671077BU7-β1-BI167107
31.58Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
31.58Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
31.58Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
31.58Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
31.58Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
31.58Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
31.58Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
31.58Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
31.58Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
31.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
31.58Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
31.58Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
31.58Single8X64Desloratadine8X64-H1-Desloratadine
31.58Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
31.58Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
31.58Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
31.58Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
31.58Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.58Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
31.58Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
31.58Consensuscck_offOrthosteric Ligandccka_off
31.58Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
31.58Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Consensusgi_hcarOrthosteric Ligandgi_hca
31.58Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.58Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
31.25Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
31.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
31.25Single8GGREpinephrine8GGR-β2-Epinephrine
31.25Single8GGZEpinephrine8GGZ-β2-Epinephrine
31.25Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.25Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
31.03Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
31.03Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
30.77Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
30.77Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
30.43Single5WF6UK-4320975WF6-A2A-UK-432097
30.43Single5ZTYAM102575ZTY-CB2-AM10257
30.43Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
30.43Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
30.43Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.43Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
30.43Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
30.43Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
30.43Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
30.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
30.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.00Single5N2SPSB365N2S-A1-PSB36
30.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
30.00Single5WIUNemonapride5WIU-D4-Nemonapride
30.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
30.00Single5WQCEMPA5WQC-OX2-EMPA
30.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
30.00Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
30.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
30.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
30.00Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
30.00Single6TP6Filorexant6TP6-OX1-Filorexant
30.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
30.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
30.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7SINNPS-21437SIN-CaS-NPS-2143
30.00Single7WC6LSD7WC6-5-HT2A-LSD
30.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.00Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
30.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
30.00Single8QOTNanobody E8QOT-μ-Nanobody E
30.00Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
30.00Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
30.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
30.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
30.00Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
30.00Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
30.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
30.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
30.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
29.63Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
29.63Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
29.63Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.63Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single6HLLCP999946HLL-NK1-CP99994
29.41Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
29.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
29.41Single7SRQLSD7SRQ-5-HT2B-LSD
29.41Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
29.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
29.41Single8GGSEpinephrine8GGS-β2-Epinephrine
29.41Single8GGYEpinephrine8GGY-β2-Epinephrine
29.41Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
29.41Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
29.41Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
29.41Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
29.41Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
29.41Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
29.17Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
29.17Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.17Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
29.17Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
29.17Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
29.17Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
29.17Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
28.57Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5V54Methiothepin5V54-5-HT1B-Methiothepin
28.57Single5X93K-87945X93-ETB-K-8794
28.57Single5XR8AM8415XR8-CB1-AM841
28.57Single6E59L-7607356E59-NK1-L-760735
28.57Single6WGTLSD6WGT-5-HT2A-LSD
28.57Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
28.57Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
28.57Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
28.57Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
28.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
28.57Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
28.57Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
28.57Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
28.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
28.57Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
28.57Consensus5ht1_offOrthosteric Ligand5ht1b_off
28.57Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
28.57Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
28.57Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
28.57Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.57Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
28.57Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
28.57Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
28.57Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
28.57Consensushistamine_offOrthosteric Ligandh1_off
28.57Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
28.57Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
28.57Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
28.57Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
28.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
28.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
28.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
28.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
28.00Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
27.78Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
27.78Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
27.78Single4S0VSuvorexant4S0V-OX2-Suvorexant
27.78Single5DHHSB-6121115DHH-NOP-SB-612111
27.78Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
27.78Single5WS3EMPA5WS3-OX2-EMPA
27.78Single6AKXA4R6AKX-CCR5-A4R
27.78Single6KUXRS-799486KUX-α2a-RS-79948
27.78Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
27.78Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
27.78Single6TPJSuvorexant6TPJ-OX2-Suvorexant
27.78Single7BR3Elagolix7BR3-GnRH1-Elagolix
27.78Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
27.78Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
27.78Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
27.78Single7F8ULintitript7F8U-CCKA-Lintitript
27.78Single7F8YDevazepide7F8Y-CCKA-Devazepide
27.78Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
27.78Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
27.78Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
27.78Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
27.78Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
27.78Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.78Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
27.78Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
27.78Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
27.78Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
27.78Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.78Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
27.78Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
27.78Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
27.78Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
27.78Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.78Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
27.78Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.59Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.59Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
27.59Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
27.59Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
27.59Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
27.27Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.27Single6A93Risperidone6A93-5-HT2A-Risperidone
27.27Single6CM4Risperidone6CM4-D2-Risperidone
27.27Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
27.27Single6HLPNetupitant6HLP-NK1-Netupitant
27.27Single6ZG4HTL00099366ZG4-M1-HTL0009936
27.27Single7DFPSpiperone7DFP-D2-Spiperone
27.27Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
27.27Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
27.27Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.27Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
27.27Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
27.27Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.27Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
27.27Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
27.27Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
27.27Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
27.27Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
27.27Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
27.27Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
27.27Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
27.27Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.27Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.27Consensusgs_steroidOrthosteric Ligandgs_bileacid
27.27Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
27.27Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
26.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.92Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
26.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.92Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
26.92Consensusangiotensin_onOrthosteric Ligandat1_on
26.92Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
26.92Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
26.92Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.92Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
26.92Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
26.92Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
26.67Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
26.32Single3RZECidoxepin3RZE-H1-Cidoxepin
26.32Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.32Single6A94Zotepine6A94-5-HT2A-Zotepine
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.32Single6TP3Nemorexant6TP3-OX1-Nemorexant
26.32Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
26.32Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
26.32Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
26.32Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
26.32Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.32Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.32Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.32Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
26.32Single8K5CAcipimox8K5C-HCA2-Acipimox
26.32Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.32Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
26.32Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
26.32Consensusgnrh_offOrthosteric Ligandgnrh1_off
26.32Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
26.32Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.32Consensushcar_onOrthosteric Ligandhca_on
26.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.09Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
26.09Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
26.09Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
26.09Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
26.09Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
26.09Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
26.09Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
26.09Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.09Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
26.09Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
26.09Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
26.09Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.09Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
26.09Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
26.09Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
26.09Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
26.09Consensussteroid_onOrthosteric Ligandbileacid_on
25.93Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.93Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.93Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.93Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.93Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
25.93Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
25.93Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
25.93Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single2Y01Dobutamine2Y01-β1-Dobutamine
25.00Single2Y02Carmoterol2Y02-β1-Carmoterol
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
25.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
25.00Single5UENDU1725UEN-A1-DU172
25.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
25.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
25.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
25.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
25.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
25.00Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single8X5YAstemizole8X5Y-H1-Astemizole
25.00Single8X63Mepyramine8X63-H1-Mepyramine
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
25.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
25.00Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
25.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
25.00Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
25.00Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
25.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
25.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
25.00Consensussensory_onOrthosteric Ligandopsin_on
25.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
25.00Consensustar_onOrthosteric Ligandta1_on
24.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
24.14Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
24.14Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
24.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
24.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
24.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
24.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
24.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
23.81Single2Y00Dobutamine2Y00-β1-Dobutamine
23.81Single5NM2ZM2413855NM2-A2A-ZM241385-Na
23.81Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.81Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
23.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.81Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
23.81Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
23.81Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.81Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
23.81Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.81Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
23.81Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
23.81Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.81Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.81Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.81Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
23.81Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
23.81Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.53Single3UZAGTPL92363UZA-A2A-GTPL9236
23.53Single6ME9Ramelteon6ME9-MT2-Ramelteon
23.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
23.53Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
23.53Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
23.53Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
23.53Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
23.53Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.53Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
23.53Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
23.53Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
23.08Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
23.08Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
23.08Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
23.08Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
23.08Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
23.08Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.08Consensussst_offOrthosteric Ligandsst2_off
22.73Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.73Single4U15Tiotropium4U15-M3-Tiotropium
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
22.73Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
22.73Single6OL9Tiotropium6OL9-M5-Tiotropium
22.73Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.73Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
22.73Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
22.73Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
22.73Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
22.73Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
22.73Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
22.73Single7TUYGSK682753A7TUY-GPR183-GSK682753A
22.73Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
22.73Single7W41PD1762527W41-BB2-PD176252
22.73Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
22.73Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
22.73Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
22.73Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
22.73Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
22.73Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
22.73Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
22.73Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
22.73Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
22.73Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
22.73Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
22.73Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
22.73Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
22.73Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
22.73Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.73Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.73Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
22.73Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
22.73Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
22.73Consensusbombesin_offOrthosteric Ligandbb2_off
22.73Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.73Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
22.73Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Consensuslpa_offOrthosteric Ligandlpa1_off
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
22.73Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
22.73Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
22.73Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
22.22Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
22.22Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.22Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
22.22Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
22.22Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
22.22Single6TP4ACT-4622066TP4-OX1-ACT-462206
22.22Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
22.22Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7XNACYN1548067XNA-SST2-CYN154806
22.22Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
22.22Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
22.22Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
22.22Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
22.22Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8K5BNiacin8K5B-HCA2-Niacin
22.22Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
22.22Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
22.22Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.88Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.74Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
21.74Single4PY02MeSATP4PY0-P2Y12-2MeSATP
21.74Single4XEENeurotensin4XEE-NTS1-Neurotensin
21.74Single4XESNeurotensin4XES-NTS1-Neurotensin
21.74Single5CXVTiotropium5CXV-M1-Tiotropium
21.74Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
21.74Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
21.74Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.74Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
21.74Single8JWZAB9288JWZ-A2A-AB928-Na
21.74Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
21.74Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
21.74Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.74Consensusblt_offOrthosteric Ligandblt1_off
21.74Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
21.74Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.74Consensusdp_offOrthosteric Liganddp2_off
21.74Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
21.74Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
21.74Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
21.74Consensusnts_offOrthosteric Ligandnts1_off
21.43Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
21.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
21.43Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
21.43Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
21.43Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.21Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
21.05Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
21.05Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
21.05Single3PWHZM2413853PWH-A2A-ZM241385
21.05Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
21.05Single5K2DZM2413855K2D-A2A-ZM241385
21.05Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.05Single6AKYMaraviroc6AKY-CCR5-Maraviroc
21.05Single6JZHZM2413856JZH-A2A-ZM241385-Na
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
21.05Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.05Single6PS7ZM2413856PS7-A2A-ZM241385-Na
21.05Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
21.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.05Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
21.05Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
21.05Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.05Single7XRRLemborexant7XRR-OX2-Lemborexant
21.05Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
21.05Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
21.05Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
21.05Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.05Single8IHKAcifran8IHK-HCA3-Acifran
21.05Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.05Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.05Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
21.05Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
21.05Consensusgt_class-aOrthosteric Ligandgt_opsin
21.05Consensusgt_opsinOrthosteric Ligandgt_sensory
21.05Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
21.05Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
21.05Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
21.05Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
20.83Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.83Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.83Single6K1QIRL25006K1Q-ETB-IRL2500
20.83Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
20.83Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.83Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
20.83Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
20.83Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.83Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.83Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
20.83Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.83Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
20.69Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
20.00Single3REYPubChem 56973REY-A2A-PubChem 5697
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
20.00Single5IU4ZM2413855IU4-A2A-ZM241385-Na
20.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5JTBZM2413855JTB-A2A-ZM241385
20.00Single5K2BZM2413855K2B-A2A-ZM241385-Na
20.00Single5K2CZM2413855K2C-A2A-ZM241385-Na
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single5NLXZM2413855NLX-A2A-ZM241385-Na
20.00Single5NM4ZM2413855NM4-A2A-ZM241385-Na
20.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5UVIZM2413855UVI-A2A-ZM241385
20.00Single6AQFZM2413856AQF-A2A-ZM241385
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
20.00Single6MH8ZM2413856MH8-A2A-ZM241385
20.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
20.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single6ZINSR486926ZIN-NTS1-SR48692
20.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
20.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
20.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
20.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
20.00Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
20.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7SK9CCX6627SK9-ACKR3-CCX662
20.00Single7T32ZM2413857T32-A2A-ZM241385
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
20.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
20.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
20.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
20.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
20.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
20.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
20.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
20.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
20.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
20.00Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
20.00Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
20.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
20.00Consensuss1p_offOrthosteric Ligands1p1_off
20.00Consensussensory_offOrthosteric Ligandopsin_off
19.35Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.35Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
19.35Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
19.23Single4XT1Fractalkine4XT1-US28-Fractalkine
19.23Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
19.23Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Consensusclass-d_offOrthosteric Ligandste2_off
19.23Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
19.05Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
19.05Single3EMLZM2413853EML-A2A-ZM241385
19.05Single4DAJTiotropium4DAJ-M3-Tiotropium
19.05Single4EIYZM2413854EIY-A2A-ZM241385-Na
19.05Single4MQSIperoxo4MQS-M2-Iperoxo
19.05Single4U14Tiotropium4U14-M3-Tiotropium
19.05Single5DSGTiotropium5DSG-M4-Tiotropium
19.05Single5IU8Q274563475IU8-A2A-Q27456347-Na
19.05Single5K2AZM2413855K2A-A2A-ZM241385-Na
19.05Single5OLGZM2413855OLG-A2A-ZM241385-Na
19.05Single5TGZAM65385TGZ-CB1-AM6538
19.05Single5VRAZM2413855VRA-A2A-ZM241385-Na
19.05Single6D27CAY104716D27-DP2-CAY10471
19.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
19.05Single6GPSMK08126GPS-CCR2-MK0812
19.05Single6LPJZM2413856LPJ-A2A-ZM241385-Na
19.05Single6LPKZM2413856LPK-A2A-ZM241385-Na
19.05Single6S0LZM2413856S0L-A2A-ZM241385
19.05Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
19.05Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.05Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
19.05Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
19.05Single7PYRPSB-21157PYR-A2A-PSB-2115
19.05Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
19.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
19.05Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
19.05Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
19.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
19.05Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
19.05Consensusa2_offOrthosteric Liganda2a_off
19.05Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
19.05Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
19.05Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
19.05Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
19.05Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.75Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
18.75Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
18.75Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
18.75Single8IY6Endothelin-18IY6-ETB-Endothelin-1
18.75Single8PWNTheophylline8PWN-A2A-Theophylline
18.75Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.75Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
18.52Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.52Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
18.18Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
18.18Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
18.18Single5CGCHTL142425CGC-mGlu5-HTL14242
18.18Single5IUAQ274563485IUA-A2A-Q27456348-Na
18.18Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
18.18Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.18Single6GPXMK08126GPX-CCR2-MK0812
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6LPLZM2413856LPL-A2A-ZM241385-Na
18.18Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
18.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
18.18Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
18.18Single6S0QZM2413856S0Q-A2A-ZM241385
18.18Single6WQAZM2413856WQA-A2A-ZM241385-Na
18.18Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
18.18Single6Z4SSR486926Z4S-NTS1-SR48692
18.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.18Single7C4SS1P7C4S-S1P3-S1P
18.18Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
18.18Single7RM5ZM2413857RM5-A2A-ZM241385-Na
18.18Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
18.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
18.18Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
18.18Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
18.18Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.18Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8EA0Iperoxo8EA0-M3-Iperoxo
18.18Single8FYNZM2413858FYN-A2A-ZM241385-Na
18.18Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.18Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
18.18Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
18.18Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.86Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.86Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
17.86Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
17.65Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
17.65Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
17.65Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.65Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
17.65Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
17.39Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
17.39Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
17.39Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single5TZR-5TZR-FFA1 (GPR40)-MK8666
17.39Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.39Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
17.39Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
17.39Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
17.39Single7PX4PSB-21137PX4-A2A-PSB-2113
17.39Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
17.39Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
17.39Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
17.39Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
17.39Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
17.39Consensuschemerin_onOrthosteric Ligandcml1_on
17.39Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
17.39Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
17.39Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Consensusrelaxin_onOrthosteric Ligandrxfp4_on
17.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.24Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.24Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.24Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
16.67Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
16.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
16.67Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
16.67Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
16.67Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
16.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.67Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
16.67Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.67Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
16.67Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
16.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
16.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
16.67Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
16.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
16.67Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
16.67Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
16.67Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
16.67Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.67Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.67Consensusgi_class-fOther Ligandgi_frizzled
16.67Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
16.67Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.67Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
16.67Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.67Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
16.67Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
16.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.13Single4XT3Fractalkine4XT3-US28-Fractalkine
16.13Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
16.13Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single7SK3CXCL127SK3-ACKR3-CXCL12
16.13Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.13Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.13Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
16.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.00Single5CGDHTL142425CGD-mGlu5-HTL14242
16.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
16.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
16.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
16.00Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
16.00Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
16.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.79Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
15.79Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.79Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
15.79Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.79Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.79Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
15.79Consensusclass-t_onOrthosteric Ligandtaste2_on
15.79Consensusgs_class-tOrthosteric Ligandgs_taste
15.79Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.79Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
15.79Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
15.62Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.62Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.62Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
15.62Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.38Single5EE7MK08935EE7-Glucagon-MK0893
15.38Single6KNMJN241-96KNM-Apelin-JN241-9
15.38Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
15.38Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.38Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusclass-d_offOrthosteric Ligandste2_off
15.38Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
15.15Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
15.15Single6LMLGlucagon6LML-Glucagon-Glucagon
15.15Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.15Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.15Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
15.15Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
15.15Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
15.15Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
15.00Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
15.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
15.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
14.81Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.81Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
14.81Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
14.71Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
14.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.71Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
14.29Single6FFIMMPEP6FFI-mGlu5-MMPEP
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
14.29Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
14.29Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
14.29Single7VODCariprazine7VOD-5-HT2A-Cariprazine
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
14.29Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
14.29Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.29Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.89Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.89Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.89Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.79Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.79Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
13.64Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.64Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
13.64Single6FFHFenobam6FFH-mGlu5-Fenobam
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single6IIVDaltroban6IIV-TP-Daltroban
13.64Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
13.64Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
13.64Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
13.64Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
13.64Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.64Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.64Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
13.64Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.64Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.64Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.64Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.64Consensusblt_onOrthosteric Ligandblt1_on
13.64Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.64Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
13.64Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
13.64Consensushcar_offOrthosteric Ligandsuccinate_off
13.64Consensusleuko_onOrthosteric Ligandblt_on
13.64Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.64Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
13.64Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
13.51Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.33Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
13.33Consensusclass-d_onOrthosteric Ligandste2_on
13.33Consensusgi_class-dOrthosteric Ligandgi_ste
13.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
13.16Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.16Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.04Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
13.04Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.04Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.04Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
13.04Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.04Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
12.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
12.90Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
12.90Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
12.82Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
12.50Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
12.50Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.50Single6FJ3PTH6FJ3-PTH1-PTH
12.50Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single6OS1TRV0266OS1-AT1-TRV026
12.50Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.50Single7EPENAM5637EPE-mGlu-NAM563
12.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50Single7P2L4YI7P2L-mGlu5-4YI
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
12.50Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
12.50Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.50Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
12.50Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
12.50Consensusclass-d_onOrthosteric Ligandste2_on
12.50Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
12.50Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
12.20Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.12Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.12Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.12Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.12Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.12Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.12Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.12Consensusgi_class-dOrthosteric Ligandgi_ste
12.12Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.12Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
12.12Consensusgo_class-b1Orthosteric Ligandgo_crf
12.12Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
12.00Single5X33BIIL2605X33-BLT1-BIIL260
12.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.00Single6IIURamatroban6IIU-TP-Ramatroban
12.00Single6OS2TRV0266OS2-AT1-TRV026
12.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
12.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
12.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.00Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
12.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
12.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
12.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusnts_onOrthosteric Ligandnts1_on
11.76Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Consensusclass-c_onOther Ligandgabab_on mglu_on
11.76Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
11.76Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
11.63Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
11.54Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
11.54Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
11.54Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.54Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.54Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
11.54Consensuscyslt_offOrthosteric Ligandcyslt2_off
11.54Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.43Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.11Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
11.11Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
11.11Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
11.11Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.81Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
10.81Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
10.71Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
10.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.53Single3OE6IT1t3OE6-CXCR4-IT1t
10.53Single3OE8IT1t3OE8-CXCR4-IT1t
10.53Single4XNWMRS25004XNW-P2Y1-MRS2500
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
10.53Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.53Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.34Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
10.34Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
10.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.00Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
10.00Single7UL2SR486927UL2-NTS1-SR48692-Na
10.00Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
10.00Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
10.00Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
10.00Consensusgo_class-b2Orthosteric Ligandgo_adhesion
10.00Consensusgo_proteinOrthosteric Ligandgo_chemokine
10.00Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.76Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
9.68Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.68Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
9.52Single3ODUIT1t3ODU-CXCR4-IT1t
9.52Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.52Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.52Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.52Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.52Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
9.52Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.52Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.52Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
9.38Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.38Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.38Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
9.30Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
9.09Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.09Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
9.09Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.09Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.09Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
9.09Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
9.09Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
9.09Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.09Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
9.09Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.82Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.70Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
8.70Single5T04Neurotensin5T04-NTS1-Neurotensin
8.70Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
8.70Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
8.70Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.70Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
8.70Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.70Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
8.70Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
8.57Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
8.57Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
8.57Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
8.57Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.33Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
8.33Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.33Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.33Consensusep_offOrthosteric Ligandep4_off
8.33Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.33Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.00Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.00Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
7.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
7.69Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.69Consensuschemokine_offOrthosteric Ligandcxcr_off
7.69Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
7.69Consensuscxcr_offOrthosteric Ligandcxcr4_off
7.41Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
7.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
7.14Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Consensusgs_class-b2Orthosteric Ligandgs_adgr
6.98Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.90Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
6.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.88Single6W25Ca6W25-MC4-SHU9119-Ca
5.56Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.56Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
5.56Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.26Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.00Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
5.00Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7FEEZCZ0117FEE-CB1-PubMed 104895-ZCZ011
4.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.76Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
4.76Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single4XNVBPTU4XNV-P2Y1-BPTU
4.55Single5U09Taranabant5U09-CB1-Taranabant
4.55Single5ZKQABT-4915ZKQ-PAF-ABT-491
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
4.55Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
4.55Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
4.55Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
4.55Consensusclass-f_offOrthosteric Ligandsmo_off
4.55Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.35Single7VV6C48/807VV6-MRGPRX2-C48/80
4.35Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8IYXYL-3658IYX-GPR34-YL-365
4.35Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
4.35Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/&β;1/&γ;2
4.17Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
3.85Single5V56TC1145V56-SMO-TC114
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.57Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.57Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.03Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.78Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)

PDB Summary
PDB 7XW9
Class A
SubFamily Peptide
Type Thyrotropin-releasing hormone
SubType TRH
Species Homo sapiens
Ligand TRH
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.7
Date 2022-12-28
D.O.I. 10.1038/s41421-022-00477-0
Net Summary
Imin 2.69
Number of Linked Nodes 870
Number of Links 1100
Number of Hubs 200
Number of Links mediated by Hubs 698
Number of Communities 29
Number of Nodes involved in Communities 265
Number of Links involved in Communities 385
Path Summary
Number Of Nodes in MetaPath 166
Number Of Links MetaPath 165
Number of Shortest Paths 43692588
Length Of Smallest Path 3
Average Path Length 114.317
Length of Longest Path 82
Minimum Path Strength 1.155
Average Path Strength 8.01789
Maximum Path Strength 22.445
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.66667
Average % Of Corr. Nodes 43.156
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 65.9716
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePCA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodePCA
NamePidolic acid
Synonyms5-L-oxoproline
Identifier(2S)-5-oxopyrrolidine-2-carboxylic acid
FormulaC5 H7 N O3
Molecular Weight129.114
SMILESC1CC(=O)N[C@@H]1C(=O)O
PubChem7405
Formal Charge0
Total Atoms16
Total Chiral Atoms1
Total Bonds16
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?4
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier$l^{2}-azane
FormulaH2 N
Molecular Weight16.023
SMILES[NH2]
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP34981
Sequence
>7XW9_Chain_R
QLQPRAVVA LEYQVVTIL LVLIICGLG IVGNIMVVL VVMRTKHMR 
TPTNCYLVS LAVADLMVL VAAGLPNIT DSIYGSWVY GYVGCLCIT 
YLQYLGINA SSCSITAFT IERYIAICH PIKAQFLCT FSRAKKIII 
FVWAFTSLY CMLWFFLLD LNISTYKDA IVISCGYKI SRNYYSPIY 
LMDFGVFYV VPMILATVL YGFIARILF LTVSSRKQV TKMLAVVVI 
LFALLWMPY RTLVVVNSF LSSPFQENW FLLFCRICI YLNSAINPV 
IYNLMSQKF RAAFRKLCN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7XW9_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAR RELKLLLLG TGESGKSTF 
IKQGIFETK FQVDKVNFH MFDVGGQRD ERRKWIQCF NDVTAIIFV 
VDSSDYNRL QEALNDFKS IWNNRWLRT ISVILFLNK QDLLAEKVL 
AGKSKIEDY FPEFARYTT PEDATPEPG EDPRVTRAK YFIRKEFVD 
ISTASGDGR HICYPHFTC AVDTENARR IFNDCKDII LQMNLREYN 
LV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7XW9_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7XW9_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
trh_on7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
gs_trh7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WKDAPeptideThyrotropin-releasing hormoneTRHHomo sapiensTRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;23.012022-06-1510.1038/s41422-022-00641-x
7X1TAPeptideThyrotropin-releasing hormoneTRHHomo sapiensTaltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.262022-08-3110.1038/s41422-022-00646-6
7X1UAPeptideThyrotropin-releasing hormoneTRHHomo sapiensTRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;23.192022-08-3110.1038/s41422-022-00646-6
7XW9APeptideThyrotropin-releasing hormoneTRHHomo sapiensTRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;22.72022-12-2810.1038/s41421-022-00477-0




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