psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:D2	10.94	Yes	Yes	1	0	0
2	L:L:?1	R:R:Y181	6.3	Yes	Yes	1	0	4
3	L:L:?1	R:R:R185	6.53	Yes	Yes	1	0	2
4	L:L:?1	R:R:N289	5.54	Yes	No	1	0	4
5	L:L:?1	R:R:L302	5.58	Yes	No	1	0	4
6	L:L:D2	R:R:Y282	16.09	Yes	Yes	1	0	5
7	L:L:D2	R:R:V286	7.3	Yes	No	1	0	6
8	L:L:D2	R:R:L302	4.07	Yes	No	1	0	4
9	L:L:?5	L:L:P4	8.13	Yes	Yes	1	0	0
10	L:L:P4	R:R:Q105	9.47	Yes	Yes	0	0	7
11	L:L:P4	R:R:Y106	4.17	Yes	No	1	0	5
12	L:L:P4	R:R:Y282	4.17	Yes	Yes	1	0	5
13	L:L:P4	R:R:R306	8.65	Yes	Yes	1	0	5
14	L:L:?5	R:R:R306	21.05	Yes	Yes	1	0	5
15	L:L:?5	R:R:Y310	8.7	Yes	Yes	1	0	7
16	R:R:L303	R:R:T28	10.32	No	No	0	4	5
17	R:R:I307	R:R:L31	5.71	No	No	0	5	4
18	R:R:V32	R:R:Y310	3.79	No	Yes	0	7	7
19	R:R:I83	R:R:L33	11.42	No	No	0	6	3
20	R:R:I307	R:R:I35	4.42	No	No	0	5	7
21	R:R:C36	R:R:L75	6.35	No	No	0	6	7
22	R:R:C36	R:R:G79	3.92	No	No	1	6	7
23	R:R:C36	R:R:Y310	9.41	No	Yes	1	6	7
24	R:R:I40	R:R:V76	7.68	No	No	0	6	4
25	R:R:G42	R:R:M45	5.24	No	No	0	8	7
26	R:R:G42	R:R:P317	4.06	No	No	0	8	9
27	R:R:A68	R:R:N43	4.69	No	Yes	0	9	9
28	R:R:D71	R:R:N43	6.73	Yes	Yes	0	9	9
29	R:R:N43	R:R:P317	11.4	Yes	No	0	9	9
30	R:R:A68	R:R:V46	5.09	No	No	0	9	9
31	R:R:N321	R:R:V46	5.91	No	No	0	7	9
32	R:R:M51	R:R:V47	4.56	No	No	0	4	7
33	R:R:F331	R:R:V49	3.93	No	No	2	7	8
34	R:R:L334	R:R:V49	7.45	No	No	2	6	8
35	R:R:N61	R:R:V50	5.91	Yes	No	0	9	8
36	R:R:V50	R:R:V65	4.81	No	No	0	8	6
37	R:R:H55	R:R:T53	5.48	No	No	0	5	6
38	R:R:F139	R:R:R57	4.28	No	No	0	3	8
39	R:R:P59	R:R:T58	5.25	No	No	0	6	7
40	R:R:T58	R:R:T60	4.71	No	No	0	7	9
41	R:R:N61	R:R:T58	5.85	Yes	No	0	9	7
42	R:R:A142	R:R:P59	3.74	No	No	0	7	6
43	R:R:F119	R:R:T60	6.49	Yes	No	0	9	9
44	R:R:F327	R:R:N61	4.83	Yes	Yes	0	8	9
45	R:R:F119	R:R:Y63	6.19	Yes	Yes	0	9	8
46	R:R:E122	R:R:Y63	17.96	No	Yes	0	8	8
47	R:R:I145	R:R:Y63	4.84	Yes	Yes	0	6	8
48	R:R:I146	R:R:Y63	6.04	No	Yes	0	7	8
49	R:R:L64	R:R:N321	4.12	No	No	0	8	7
50	R:R:S115	R:R:S66	4.89	No	No	0	8	9
51	R:R:I146	R:R:S66	9.29	No	No	0	7	9
52	R:R:S66	R:R:W150	4.94	No	Yes	0	9	9
53	R:R:D71	R:R:L67	8.14	Yes	Yes	1	9	9
54	R:R:L67	R:R:S115	4.5	Yes	No	0	9	8
55	R:R:I116	R:R:L67	5.71	No	Yes	0	8	9
56	R:R:L67	R:R:N316	8.24	Yes	No	1	9	9
57	R:R:V69	R:R:W150	3.68	No	Yes	0	7	9
58	R:R:D71	R:R:S112	7.36	Yes	No	1	9	9
59	R:R:D71	R:R:S313	8.83	Yes	No	1	9	9
60	R:R:D71	R:R:N316	9.42	Yes	No	1	9	9
61	R:R:L107	R:R:M73	5.65	Yes	No	0	5	6
62	R:R:G108	R:R:V74	3.68	No	No	0	7	7
63	R:R:A78	R:R:Q105	6.06	No	Yes	0	7	7
64	R:R:G79	R:R:Y310	5.79	No	Yes	1	7	7
65	R:R:I83	R:R:L80	4.28	No	No	0	6	8
66	R:R:P81	R:R:W91	5.4	No	Yes	0	5	8
67	R:R:I101	R:R:P81	5.08	No	No	0	5	5
68	R:R:P81	R:R:Q105	6.32	No	Yes	0	5	7
69	R:R:N82	R:R:Y310	8.14	No	Yes	0	6	7
70	R:R:I83	R:R:T84	6.08	No	No	0	6	4
71	R:R:D85	R:R:T84	5.78	No	No	0	4	4
72	R:R:T84	R:R:Y93	8.74	No	No	0	4	6
73	R:R:D85	R:R:W91	7.82	No	Yes	0	4	8
74	R:R:D85	R:R:V92	5.84	No	No	0	4	4
75	R:R:S90	R:R:Y88	10.17	No	No	0	5	5
76	R:R:V92	R:R:Y88	6.31	No	No	0	4	5
77	R:R:S90	R:R:V176	6.46	No	No	0	5	3
78	R:R:W91	R:R:Y93	13.5	Yes	No	0	8	6
79	R:R:G94	R:R:W91	4.22	No	Yes	0	7	8
80	R:R:C98	R:R:W91	13.06	No	Yes	4	9	8
81	R:R:S178	R:R:W91	6.18	No	Yes	0	4	8
82	R:R:C179	R:R:W91	24.81	No	Yes	4	9	8
83	R:R:L99	R:R:Y95	17.58	No	No	0	5	3
84	R:R:D165	R:R:Y95	12.64	No	No	0	5	3
85	R:R:C179	R:R:C98	7.28	No	No	4	9	9
86	R:R:L164	R:R:L99	4.15	No	No	0	5	5
87	R:R:Q105	R:R:T102	5.67	Yes	No	0	7	4
88	R:R:L164	R:R:T102	4.42	No	No	0	5	4
89	R:R:C157	R:R:Y103	8.06	No	No	0	7	6
90	R:R:F161	R:R:Y103	7.22	Yes	No	0	5	6
91	R:R:W160	R:R:Y106	41.48	Yes	No	1	5	5
92	R:R:Y106	R:R:Y192	8.94	No	Yes	1	5	5
93	R:R:L107	R:R:T153	4.42	Yes	No	0	5	8
94	R:R:C157	R:R:L107	6.35	No	Yes	0	7	5
95	R:R:I109	R:R:W279	7.05	Yes	Yes	1	7	8
96	R:R:I109	R:R:R283	3.76	Yes	Yes	1	7	6
97	R:R:I109	R:R:R306	5.01	Yes	Yes	1	7	5
98	R:R:I109	R:R:I309	4.42	Yes	Yes	1	7	6
99	R:R:D195	R:R:N110	17.5	Yes	No	1	6	6
100	R:R:F199	R:R:N110	21.75	Yes	No	1	5	6
101	R:R:A111	R:R:W150	6.48	No	Yes	0	7	9
102	R:R:S112	R:R:S313	4.89	No	No	1	9	9
103	R:R:F199	R:R:S113	5.28	Yes	No	1	5	7
104	R:R:F275	R:R:S113	5.28	Yes	No	1	9	7
105	R:R:S113	R:R:W279	7.41	No	Yes	1	7	8
106	R:R:C114	R:R:F199	8.38	No	Yes	0	5	5
107	R:R:F275	R:R:I116	6.28	Yes	No	0	9	8
108	R:R:I116	R:R:Y320	10.88	No	Yes	0	8	9
109	R:R:T117	R:R:V202	4.76	No	No	0	7	5
110	R:R:F119	R:R:R123	7.48	Yes	No	3	9	9
111	R:R:F119	R:R:Y320	4.13	Yes	Yes	3	9	9
112	R:R:C137	R:R:E122	6.08	No	No	0	7	8
113	R:R:E122	R:R:R141	10.47	No	No	0	8	5
114	R:R:R123	R:R:Y211	11.32	No	Yes	0	9	9
115	R:R:R123	R:R:Y320	6.17	No	Yes	3	9	9
116	R:R:C128	R:R:Y124	5.38	No	Yes	0	7	8
117	R:R:H129	R:R:Y124	4.36	No	Yes	0	6	8
118	R:R:L210	R:R:Y124	16.41	No	Yes	0	7	8
119	R:R:F213	R:R:Y124	7.22	No	Yes	0	5	8
120	R:R:I127	R:R:I214	4.42	No	No	5	9	9
121	R:R:C128	R:R:I217	4.91	No	No	0	7	6
122	R:R:F139	R:R:K143	8.69	No	No	0	3	4
123	R:R:I145	R:R:R141	5.01	Yes	No	0	6	5
124	R:R:D195	R:R:Y156	13.79	Yes	No	0	6	5
125	R:R:F161	R:R:M158	6.22	Yes	No	0	5	4
126	R:R:W160	R:R:Y188	14.47	Yes	Yes	1	5	5
127	R:R:I191	R:R:W160	19.97	No	Yes	1	7	5
128	R:R:W160	R:R:Y192	7.72	Yes	Yes	1	5	5
129	R:R:I183	R:R:L163	5.71	No	No	0	2	4
130	R:R:L163	R:R:Y188	9.38	No	Yes	0	4	5
131	R:R:D165	R:R:L166	5.43	No	No	0	5	4
132	R:R:D165	R:R:K182	11.06	No	No	0	5	4
133	R:R:I177	R:R:N167	8.5	No	No	0	4	1
134	R:R:I168	R:R:I175	8.83	No	No	0	5	5
135	R:R:I177	R:R:S169	10.84	No	No	0	4	1
136	R:R:I175	R:R:T170	10.64	No	No	0	5	1
137	R:R:A174	R:R:D173	4.63	No	No	0	4	3
138	R:R:R185	R:R:Y181	13.38	Yes	Yes	1	2	4
139	R:R:Y181	R:R:Y188	3.97	Yes	Yes	1	4	5
140	R:R:Y181	R:R:Y192	6.95	Yes	Yes	1	4	5
141	R:R:S184	R:R:Y187	3.82	No	No	0	4	1
142	R:R:R185	R:R:Y192	8.23	Yes	Yes	1	2	5
143	R:R:N289	R:R:R185	8.44	No	Yes	1	4	2
144	R:R:I191	R:R:Y188	14.51	No	Yes	1	7	5
145	R:R:Y188	R:R:Y192	6.95	Yes	Yes	1	5	5
146	R:R:S189	R:R:S290	6.52	No	Yes	1	3	4
147	R:R:V286	R:R:Y192	10.09	No	Yes	1	6	5
148	R:R:D195	R:R:F199	9.55	Yes	Yes	1	6	5
149	R:R:D195	R:R:R283	4.76	Yes	Yes	1	6	6
150	R:R:F196	R:R:Y200	7.22	No	Yes	0	6	8
151	R:R:F199	R:R:V198	13.11	Yes	No	0	5	5
152	R:R:M204	R:R:Y200	7.18	No	Yes	0	6	8
153	R:R:M280	R:R:Y200	8.38	No	Yes	0	6	8
154	R:R:R283	R:R:Y200	8.23	Yes	Yes	0	6	8
155	R:R:A276	R:R:M204	6.44	No	No	0	6	6
156	R:R:T208	R:R:V272	4.76	No	No	0	5	8
157	R:R:L268	R:R:Y211	18.76	No	Yes	0	8	9
158	R:R:V271	R:R:Y211	3.79	No	Yes	0	8	9
159	R:R:V272	R:R:Y211	3.79	No	Yes	0	8	9
160	R:R:I214	R:R:L268	4.28	No	No	0	9	8
161	R:R:F219	R:R:K262	7.44	No	No	0	5	5
162	R:R:K262	R:R:T265	4.5	No	No	0	5	8
163	R:R:K266	R:R:V270	6.07	No	No	0	7	7
164	R:R:M267	R:R:M323	7.22	No	No	0	9	8
165	R:R:I319	R:R:V271	4.61	No	No	0	8	8
166	R:R:V271	R:R:Y320	3.79	No	Yes	0	8	9
167	R:R:F275	R:R:W279	15.03	Yes	Yes	1	9	8
168	R:R:F275	R:R:N312	12.08	Yes	Yes	1	9	9
169	R:R:L278	R:R:L311	4.15	No	No	0	8	5
170	R:R:L278	R:R:N312	6.87	No	Yes	0	8	9
171	R:R:R283	R:R:W279	11	Yes	Yes	1	6	8
172	R:R:I309	R:R:W279	10.57	Yes	Yes	1	6	8
173	R:R:N312	R:R:W279	10.17	Yes	Yes	1	9	8
174	R:R:C305	R:R:P281	3.77	No	No	0	5	9
175	R:R:C308	R:R:P281	5.65	No	No	0	7	9
176	R:R:V286	R:R:Y282	8.83	No	Yes	1	6	5
177	R:R:R306	R:R:Y282	25.72	Yes	Yes	1	5	5
178	R:R:I309	R:R:Y282	8.46	Yes	Yes	1	6	5
179	R:R:F301	R:R:L285	4.87	Yes	No	1	4	4
180	R:R:C305	R:R:L285	4.76	No	No	1	5	4
181	R:R:F291	R:R:V288	11.8	No	No	1	5	4
182	R:R:L292	R:R:V288	4.47	No	No	1	4	4
183	R:R:N289	R:R:P295	4.89	No	No	0	4	1
184	R:R:F291	R:R:L292	6.09	No	No	1	5	4
185	R:R:E298	R:R:F296	10.49	No	No	1	3	1
186	R:R:F296	R:R:F301	5.36	No	Yes	1	1	4
187	R:R:E298	R:R:F301	4.66	No	Yes	1	3	4
188	R:R:L303	R:R:N299	4.12	No	No	0	4	1
189	R:R:C305	R:R:F301	8.38	No	Yes	1	5	4
190	R:R:I309	R:R:R306	20.04	Yes	Yes	1	6	5
191	R:R:N312	R:R:N316	4.09	Yes	No	1	9	9
192	R:R:I315	R:R:I319	4.42	No	No	6	6	8
193	R:R:F327	R:R:N321	18.12	Yes	No	0	8	7
194	R:R:L322	R:R:M323	4.24	No	No	0	5	8
195	R:R:F327	R:R:S324	3.96	Yes	No	0	8	8
196	R:R:F327	R:R:K326	3.72	Yes	No	0	8	6
197	R:R:F331	R:R:L334	4.87	No	No	2	7	6
198	R:R:F161	R:R:L99	3.65	Yes	No	0	5	5
199	R:R:A142	R:R:C62	3.61	No	No	0	7	4
200	R:R:M194	R:R:Y156	3.59	No	No	0	5	5
201	R:R:P190	R:R:S189	3.56	No	No	0	4	3
202	R:R:G37	R:R:I40	3.53	No	No	0	5	6
203	R:R:G97	R:R:I101	3.53	No	No	0	5	5
204	R:R:P203	R:R:V202	3.53	No	No	0	9	5
205	R:R:L104	R:R:Y103	3.52	No	No	0	4	6
206	R:R:F135	R:R:Q134	3.51	No	No	0	4	6
207	R:R:G108	R:R:M73	3.49	No	No	0	7	6
208	R:R:C114	R:R:V149	3.42	No	No	0	5	7
209	R:R:A207	R:R:T120	3.36	No	No	0	8	8
210	R:R:M280	R:R:P281	3.35	No	No	0	6	9
211	R:R:E298	R:R:W300	3.27	No	No	0	3	2
212	R:R:F161	R:R:F162	3.22	Yes	No	0	5	5
213	R:R:F301	R:R:F304	3.22	Yes	No	0	4	4
214	R:R:A269	R:R:K266	3.21	No	No	0	6	7
215	L:L:?5	L:L:H3	3.18	Yes	No	0	0	0
216	R:R:I307	R:R:V32	3.07	No	No	0	5	7
217	R:R:F196	R:R:G197	3.01	No	No	0	6	4
218	R:R:L107	R:R:S154	3	Yes	No	0	5	4
219	R:R:L193	R:R:V287	2.98	No	No	0	4	6
220	R:R:L210	R:R:V209	2.98	No	No	0	7	5
221	R:R:L274	R:R:V270	2.98	No	No	0	6	7
222	R:R:L322	R:R:V318	2.98	No	No	0	5	7
223	R:R:D173	R:R:V176	2.92	No	No	0	3	3
224	R:R:F275	R:R:P203	2.89	Yes	No	0	9	9
225	R:R:E23	R:R:V26	2.85	No	No	0	2	5
226	R:R:I29	R:R:L30	2.85	No	No	0	5	4
227	R:R:I44	R:R:L48	2.85	No	No	0	5	5
228	R:R:I44	R:R:L72	2.85	No	No	0	5	7
229	R:R:I191	R:R:L159	2.85	No	No	0	7	5
230	R:R:I273	R:R:L277	2.85	No	No	0	5	5
231	R:R:I315	R:R:L274	2.85	No	No	6	6	6
232	R:R:I319	R:R:L274	2.85	No	No	6	8	6
233	R:R:L72	R:R:N43	2.75	No	Yes	0	7	9
234	R:R:F327	R:R:V49	2.62	Yes	No	0	8	8
235	R:R:A70	R:R:W150	2.59	No	Yes	0	8	9
236	R:R:T120	R:R:Y211	2.5	No	Yes	0	8	9
237	R:R:T170	R:R:Y171	2.5	No	No	0	1	1
238	R:R:I125	R:R:Y124	2.42	No	Yes	0	4	8
239	R:R:A314	R:R:G39	1.95	No	No	0	8	8
240	R:R:A215	R:R:G212	1.95	No	No	0	7	3
241	R:R:W300	R:R:Y24	1.93	No	No	0	2	2
242	R:R:G42	R:R:V41	1.84	No	No	0	8	4
243	R:R:G89	R:R:V176	1.84	No	No	0	4	3
244	R:R:G197	R:R:V201	1.84	No	No	0	4	5
245	R:R:P295	R:R:S294	1.78	No	No	0	1	2
246	R:R:G39	R:R:L75	1.71	No	No	0	8	7
247	R:R:A68	R:R:V47	1.7	No	No	0	9	7
248	R:R:G180	R:R:N167	1.7	No	No	0	3	1
249	R:R:A330	R:R:T53	1.68	No	No	0	7	6
250	R:R:A215	R:R:T265	1.68	No	No	0	7	8
251	R:R:A77	R:R:I101	1.62	No	No	0	5	5
252	R:R:A118	R:R:I145	1.62	No	Yes	0	7	6
253	R:R:A133	R:R:I125	1.62	No	No	0	7	4
254	R:R:P295	R:R:Q297	1.58	No	No	0	1	3
255	R:R:I29	R:R:S86	1.55	No	No	0	5	4
256	R:R:I29	R:R:V26	1.54	No	No	0	5	5
257	R:R:I205	R:R:V201	1.54	No	No	0	4	5
258	R:R:H129	R:R:P130	1.53	No	No	0	6	8
259	R:R:K172	R:R:S169	1.53	No	No	0	1	1
260	R:R:I121	R:R:T117	1.52	No	No	0	6	7
261	R:R:M267	R:R:V264	1.52	No	No	0	9	8
262	R:R:L193	R:R:S189	1.5	No	No	1	4	3
263	R:R:L193	R:R:S290	1.5	No	Yes	1	4	4
264	R:R:G212	R:R:R216	1.5	No	No	0	3	4
265	R:R:L38	R:R:V41	1.49	No	No	0	5	4
266	R:R:L72	R:R:V76	1.49	No	No	0	7	4
267	R:R:N186	R:R:S184	1.49	No	No	0	2	4
268	R:R:L206	R:R:V202	1.49	No	No	0	6	5
269	R:R:L285	R:R:V288	1.49	No	No	1	4	4
270	R:R:I34	R:R:I35	1.47	No	No	0	4	7
271	R:R:L210	R:R:T120	1.47	No	No	0	7	8
272	R:R:I121	R:R:I125	1.47	No	No	0	6	4
273	R:R:I168	R:R:I177	1.47	No	No	0	5	4
274	R:R:L268	R:R:T265	1.47	No	No	0	8	8
275	R:R:I131	R:R:K132	1.45	No	No	0	7	5
276	R:R:I145	R:R:K144	1.45	Yes	No	0	6	3
277	R:R:G180	R:R:Y181	1.45	No	Yes	0	3	4
278	R:R:Q325	R:R:S324	1.44	No	No	0	5	8
279	R:R:I127	R:R:L218	1.43	No	No	5	9	8
280	R:R:I214	R:R:L218	1.43	No	No	5	9	8
281	R:R:I217	R:R:L218	1.43	No	No	0	6	8
282	R:R:Q25	R:R:T28	1.42	No	No	0	4	5
283	R:R:I217	R:R:N221	1.42	No	No	0	6	7
284	R:R:L220	R:R:N221	1.37	No	No	0	5	7
285	R:R:R185	R:R:S290	1.32	Yes	Yes	1	2	4
286	R:R:F291	R:R:S290	1.32	No	Yes	1	5	4
287	R:R:H129	R:R:K132	1.31	No	No	0	6	5
288	R:R:R141	R:R:T138	1.29	No	No	0	5	8
289	R:R:H55	R:R:N61	1.28	No	Yes	0	5	9
290	R:R:L48	R:R:R52	1.21	No	No	0	5	5
291	R:R:N186	R:R:R185	1.21	No	Yes	0	2	2
292	R:R:F148	R:R:F152	1.07	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.978	5	1	0
2	L:L:D2	9.6	4	1	0
3	L:L:P4	6.918	5	1	0
4	L:L:?5	10.265	4	1	0
5	R:R:N43	6.3925	4	0	9
6	R:R:N61	4.4675	4	0	9
7	R:R:Y63	8.7575	4	0	8
8	R:R:L67	6.6475	4	1	9
9	R:R:D71	8.096	5	1	9
10	R:R:W91	10.7129	7	4	8
11	R:R:Q105	6.88	4	0	7
12	R:R:L107	4.855	4	0	5
13	R:R:I109	5.06	4	1	7
14	R:R:F119	6.0725	4	3	9
15	R:R:Y124	7.158	5	0	8
16	R:R:I145	3.23	4	0	6
17	R:R:W150	4.4225	4	0	9
18	R:R:W160	20.91	4	1	5
19	R:R:F161	5.0775	4	0	5
20	R:R:Y181	6.41	5	1	4
21	R:R:R185	6.51833	6	1	2
22	R:R:Y188	9.856	5	1	5
23	R:R:Y192	8.14667	6	1	5
24	R:R:D195	11.4	4	1	6
25	R:R:F199	11.614	5	1	5
26	R:R:Y200	7.7525	4	0	8
27	R:R:Y211	8.032	5	0	9
28	R:R:F275	8.312	5	1	9
29	R:R:W279	10.205	6	1	8
30	R:R:Y282	12.654	5	1	5
31	R:R:R283	6.9375	4	1	6
32	R:R:S290	2.665	4	1	4
33	R:R:F301	5.298	5	1	4
34	R:R:R306	16.094	5	1	5
35	R:R:I309	10.8725	4	1	6
36	R:R:Y310	7.166	5	1	7
37	R:R:N312	8.3025	4	1	9
38	R:R:Y320	6.2425	4	3	9
39	R:R:F327	6.65	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:D2	18.7256	10.94	Yes	Yes	1	0	0
2	L:L:D2	R:R:Y282	20.4436	16.09	Yes	Yes	1	0	5
3	L:L:P4	R:R:Y282	29.7518	4.17	Yes	Yes	1	0	5
4	L:L:?5	R:R:R306	16.8386	21.05	Yes	Yes	1	0	5
5	L:L:P4	R:R:Q105	91.3396	9.47	Yes	Yes	0	0	7
6	R:R:R185	R:R:Y192	12.8886	8.23	Yes	Yes	1	2	5
7	L:L:?5	R:R:Y310	18.4686	8.7	Yes	Yes	1	0	7
8	R:R:P81	R:R:Q105	52.3183	6.32	No	Yes	0	5	7
9	R:R:P81	R:R:W91	44.7703	5.4	No	Yes	0	5	8
10	R:R:D85	R:R:W91	24.809	7.82	No	Yes	0	4	8
11	R:R:I83	R:R:T84	12.4837	6.08	No	No	0	6	4
12	R:R:W91	R:R:Y93	10.3503	13.5	Yes	No	0	8	6
13	R:R:I309	R:R:Y282	64.1155	8.46	Yes	Yes	1	6	5
14	R:R:I309	R:R:W279	97.6905	10.57	Yes	Yes	1	6	8
15	R:R:N312	R:R:W279	39.7465	10.17	Yes	Yes	1	9	8
16	R:R:N312	R:R:N316	38.3278	4.09	Yes	No	1	9	9
17	R:R:D71	R:R:N316	29.6075	9.42	Yes	No	1	9	9
18	R:R:D71	R:R:N43	33.297	6.73	Yes	Yes	0	9	9
19	R:R:L72	R:R:N43	10.7904	2.75	No	Yes	0	7	9
20	R:R:A68	R:R:N43	15.6311	4.69	No	Yes	0	9	9
21	R:R:A68	R:R:V46	11.5719	5.09	No	No	0	9	9
22	R:R:N321	R:R:V46	10.3045	5.91	No	No	0	7	9
23	R:R:F275	R:R:W279	100	15.03	Yes	Yes	1	9	8
24	R:R:F275	R:R:I116	88.8611	6.28	Yes	No	0	9	8
25	R:R:I116	R:R:Y320	85.1188	10.88	No	Yes	0	8	9
26	R:R:F119	R:R:Y320	31.681	4.13	Yes	Yes	3	9	9
27	R:R:F119	R:R:T60	21.9328	6.49	Yes	No	0	9	9
28	R:R:T58	R:R:T60	20.852	4.71	No	No	0	7	9
29	R:R:N61	R:R:T58	16.2894	5.85	Yes	No	0	9	7
30	R:R:F119	R:R:Y63	14.7087	6.19	Yes	Yes	0	9	8
31	R:R:I116	R:R:L67	15.5536	5.71	No	Yes	0	8	9
32	R:R:L67	R:R:S115	15.705	4.5	Yes	No	0	9	8
33	R:R:S115	R:R:S66	13.4343	4.89	No	No	0	8	9
34	R:R:Q105	R:R:T102	38.8418	5.67	Yes	No	0	7	4
35	R:R:L164	R:R:T102	36.8456	4.42	No	No	0	5	4
36	R:R:L164	R:R:L99	35.1276	4.15	No	No	0	5	5
37	R:R:F161	R:R:L99	25.0062	3.65	Yes	No	0	5	5
38	R:R:F161	R:R:Y103	18.8488	7.22	Yes	No	0	5	6
39	R:R:C157	R:R:Y103	14.7087	8.06	No	No	0	7	6
40	R:R:C157	R:R:L107	12.6281	6.35	No	Yes	0	7	5
41	R:R:D85	R:R:V92	14.6242	5.84	No	No	0	4	4
42	R:R:V92	R:R:Y88	12.5541	6.31	No	No	0	4	5
43	R:R:S90	R:R:Y88	10.477	10.17	No	No	0	5	5
44	R:R:I109	R:R:R306	45.3336	5.01	Yes	Yes	1	7	5
45	R:R:I109	R:R:R283	11.4416	3.76	Yes	Yes	1	7	6
46	R:R:R283	R:R:W279	14.6488	11	Yes	Yes	1	6	8
47	R:R:F275	R:R:P203	19.1023	2.89	Yes	No	0	9	9
48	R:R:P203	R:R:V202	17.7293	3.53	No	No	0	9	5
49	R:R:T117	R:R:V202	15.0466	4.76	No	No	0	7	5
50	R:R:R123	R:R:Y320	23.4255	6.17	No	Yes	3	9	9
51	R:R:R123	R:R:Y211	26.3264	11.32	No	Yes	0	9	9
52	R:R:V271	R:R:Y320	31.0685	3.79	No	Yes	0	8	9
53	R:R:V271	R:R:Y211	23.0276	3.79	No	Yes	0	8	9
54	R:R:I121	R:R:T117	13.8039	1.52	No	No	0	6	7
55	R:R:I121	R:R:I125	12.8675	1.47	No	No	0	6	4
56	R:R:I125	R:R:Y124	10.9945	2.42	No	Yes	0	4	8
57	R:R:T120	R:R:Y211	12.5788	2.5	No	Yes	0	8	9
58	R:R:L268	R:R:Y211	30.9664	18.76	No	Yes	0	8	9
59	R:R:I214	R:R:L268	14.2757	4.28	No	No	0	9	8
60	R:R:G180	R:R:Y181	16.2084	1.45	No	Yes	0	3	4
61	R:R:G180	R:R:N167	14.413	1.7	No	No	0	3	1
62	R:R:I177	R:R:N167	12.6105	8.5	No	No	0	4	1
63	R:R:R185	R:R:S290	13.8602	1.32	Yes	Yes	1	2	4
64	R:R:R283	R:R:Y200	19.3346	8.23	Yes	Yes	0	6	8
65	R:R:M280	R:R:Y200	10.6355	8.38	No	Yes	0	6	8
66	R:R:L268	R:R:T265	14.7615	1.47	No	No	0	8	8
67	L:L:P4	R:R:Y106	16.7647	4.17	Yes	No	1	0	5
68	R:R:V286	R:R:Y192	19.148	10.09	No	Yes	1	6	5
69	R:R:V286	R:R:Y282	19.9331	8.83	No	Yes	1	6	5
70	L:L:P4	R:R:R306	61.6758	8.65	Yes	Yes	1	0	5
71	R:R:I109	R:R:W279	36.1591	7.05	Yes	Yes	1	7	8
72	R:R:I309	R:R:R306	35.8564	20.04	Yes	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y181	6.3	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R185	6.53	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:N289	5.54	1	Yes	No	0	4	0	1
L:L:?1	R:R:L302	5.58	1	Yes	No	0	4	0	1
L:L:D2	R:R:Y282	16.09	1	Yes	Yes	0	5	0	1
L:L:D2	R:R:V286	7.3	1	Yes	No	0	6	0	1
L:L:D2	R:R:L302	4.07	1	Yes	No	0	4	0	1
L:L:P4	R:R:Q105	9.47	1	Yes	Yes	0	7	0	1
L:L:P4	R:R:Y106	4.17	1	Yes	No	0	5	0	1
L:L:P4	R:R:Y282	4.17	1	Yes	Yes	0	5	0	1
L:L:P4	R:R:R306	8.65	1	Yes	Yes	0	5	0	1
L:L:?5	R:R:R306	21.05	1	Yes	Yes	0	5	0	1
L:L:?5	R:R:Y310	8.7	1	Yes	Yes	0	7	0	1
R:R:V32	R:R:Y310	3.79	0	No	Yes	7	7	2	1
R:R:C36	R:R:G79	3.92	1	No	No	6	7	2	2
R:R:C36	R:R:Y310	9.41	1	No	Yes	6	7	2	1
R:R:A78	R:R:Q105	6.06	0	No	Yes	7	7	2	1
R:R:G79	R:R:Y310	5.79	1	No	Yes	7	7	2	1
R:R:P81	R:R:Q105	6.32	0	No	Yes	5	7	2	1
R:R:N82	R:R:Y310	8.14	0	No	Yes	6	7	2	1
R:R:Q105	R:R:T102	5.67	0	Yes	No	7	4	1	2
R:R:W160	R:R:Y106	41.48	1	Yes	No	5	5	2	1
R:R:Y106	R:R:Y192	8.94	1	No	Yes	5	5	1	2
R:R:I109	R:R:R306	5.01	1	Yes	Yes	7	5	2	1
R:R:I109	R:R:I309	4.42	1	Yes	Yes	7	6	2	2
R:R:W160	R:R:Y188	14.47	1	Yes	Yes	5	5	2	2
R:R:W160	R:R:Y192	7.72	1	Yes	Yes	5	5	2	2
R:R:R185	R:R:Y181	13.38	1	Yes	Yes	2	4	1	1
R:R:Y181	R:R:Y188	3.97	1	Yes	Yes	4	5	1	2
R:R:Y181	R:R:Y192	6.95	1	Yes	Yes	4	5	1	2
R:R:R185	R:R:Y192	8.23	1	Yes	Yes	2	5	1	2
R:R:N289	R:R:R185	8.44	1	No	Yes	4	2	1	1
R:R:Y188	R:R:Y192	6.95	1	Yes	Yes	5	5	2	2
R:R:V286	R:R:Y192	10.09	1	No	Yes	6	5	1	2
R:R:V286	R:R:Y282	8.83	1	No	Yes	6	5	1	1
R:R:R306	R:R:Y282	25.72	1	Yes	Yes	5	5	1	1
R:R:I309	R:R:Y282	8.46	1	Yes	Yes	6	5	2	1
R:R:N289	R:R:P295	4.89	1	No	No	4	1	1	2
R:R:I309	R:R:R306	20.04	1	Yes	Yes	6	5	2	1
R:R:G180	R:R:Y181	1.45	0	No	Yes	3	4	2	1
R:R:R185	R:R:S290	1.32	1	Yes	Yes	2	4	1	2
R:R:N186	R:R:R185	1.21	0	No	Yes	2	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X1T_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.68
Number of Linked Nodes	258
Number of Links	292
Number of Hubs	39
Number of Links mediated by Hubs	140
Number of Communities	6
Number of Nodes involved in Communities	60
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	60513
Length Of Smallest Path	3
Average Path Length	13.471
Length of Longest Path	26
Minimum Path Strength	1.265
Average Path Strength	7.40511
Maximum Path Strength	23.385
Minimum Path Correlation	0.7
Average Path Correlation	0.921433
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	48.6068
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.7949
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • thyrotropin-releasing hormone receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm
SCOP2	Domain Identifier	• WD40 repeat-like
SCOP2	Family Identifier	• WD40 repeat-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RGI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RGI
Name	METHYLCARBAMIC ACID
Synonyms
Identifier
Formula	C2 H5 N O2
Molecular Weight	75.067
SMILES
PubChem	30536
Formal Charge	0
Total Atoms	10
Total Chiral Atoms	0
Total Bonds	9
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34981
Sequence	>7X1T_nogp_Chain_R E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T K H M R T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S L Y G S W V Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H P I K A Q F L C T F S R A K K I I I F V W A F T S L Y C M L W F F L L D L N I S T Y K D A I V I S C G Y K I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L S S P F Q E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R A A F R K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XW9	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.7	2022-12-28	10.1038/s41421-022-00477-0
	7XW9 (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		2.7	2022-12-28	10.1038/s41421-022-00477-0
	7X1U	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.19	2022-08-31	10.1038/s41422-022-00646-6
	7X1U (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.19	2022-08-31	10.1038/s41422-022-00646-6
	7X1T	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2022-08-31	10.1038/s41422-022-00646-6
	7X1T (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-		3.26	2022-08-31	10.1038/s41422-022-00646-6
	7WKD	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.01	2022-06-15	10.1038/s41422-022-00641-x
	7WKD (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.01	2022-06-15	10.1038/s41422-022-00641-x

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