psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	11	Yes	Yes	1	0	0
2	L:L:?1	R:R:Y181	5.02	Yes	Yes	1	0	4
3	L:L:?1	R:R:R185	9.1	Yes	Yes	1	0	2
4	L:L:?1	R:R:N289	10.28	Yes	Yes	1	0	4
5	L:L:?1	R:R:L302	7.4	Yes	No	1	0	4
6	L:L:?1	R:R:R306	6.5	Yes	Yes	1	0	5
7	L:L:H2	R:R:T102	6.85	Yes	No	1	0	4
8	L:L:H2	R:R:Y106	5.44	Yes	Yes	1	0	5
9	L:L:H2	R:R:W160	7.41	Yes	Yes	1	0	5
10	L:L:H2	R:R:Y181	9.8	Yes	Yes	1	0	4
11	L:L:?4	L:L:P3	4.06	No	Yes	1	0	0
12	L:L:P3	R:R:A78	3.74	Yes	No	1	0	7
13	L:L:P3	R:R:Q105	11.05	Yes	No	1	0	7
14	L:L:P3	R:R:Y282	4.17	Yes	Yes	0	0	5
15	L:L:P3	R:R:R306	4.32	Yes	Yes	1	0	5
16	L:L:?4	R:R:N82	10.2	No	No	1	0	6
17	L:L:?4	R:R:R306	18.04	No	Yes	1	0	5
18	R:R:N299	R:R:Y24	4.65	No	No	5	1	2
19	R:R:W300	R:R:Y24	11.58	No	No	5	2	2
20	R:R:V26	R:R:V27	4.81	No	No	0	5	5
21	R:R:L303	R:R:T28	4.42	No	No	0	4	5
22	R:R:I29	R:R:S86	9.29	No	No	0	5	4
23	R:R:L30	R:R:L33	4.15	No	No	0	4	3
24	R:R:I307	R:R:L31	7.14	No	No	0	5	4
25	R:R:C36	R:R:V32	5.12	No	No	1	6	7
26	R:R:I83	R:R:V32	4.61	No	No	0	6	7
27	R:R:V32	R:R:Y310	7.57	No	Yes	1	7	7
28	R:R:I307	R:R:I35	4.42	No	No	0	5	7
29	R:R:I35	R:R:L311	5.71	No	No	0	7	5
30	R:R:C36	R:R:G79	3.92	No	No	0	6	7
31	R:R:C36	R:R:Y310	8.06	No	Yes	1	6	7
32	R:R:G37	R:R:I40	5.29	No	Yes	0	5	6
33	R:R:I40	R:R:L72	4.28	Yes	No	0	6	7
34	R:R:I40	R:R:L75	7.14	Yes	No	0	6	7
35	R:R:I40	R:R:V76	4.61	Yes	No	0	6	4
36	R:R:G42	R:R:P317	4.06	No	No	0	8	9
37	R:R:D71	R:R:N43	17.5	No	No	0	9	9
38	R:R:L72	R:R:N43	5.49	No	No	0	7	9
39	R:R:N43	R:R:P317	11.4	No	No	0	9	9
40	R:R:F331	R:R:M45	3.73	No	No	0	7	7
41	R:R:P317	R:R:V46	3.53	No	No	0	9	9
42	R:R:V47	R:R:V65	4.81	No	No	0	7	6
43	R:R:F327	R:R:V49	7.87	Yes	No	0	8	8
44	R:R:N61	R:R:V50	8.87	Yes	No	0	9	8
45	R:R:V50	R:R:V65	4.81	No	No	0	8	6
46	R:R:M56	R:R:T53	7.53	Yes	No	0	8	6
47	R:R:H55	R:R:K333	6.55	No	No	0	5	4
48	R:R:M56	R:R:N61	8.41	Yes	Yes	3	8	9
49	R:R:F327	R:R:M56	6.22	Yes	Yes	3	8	8
50	R:R:R57	R:R:T138	3.88	No	No	0	8	8
51	R:R:F139	R:R:R57	19.24	No	No	0	3	8
52	R:R:T58	R:R:T60	4.71	Yes	No	0	7	9
53	R:R:N61	R:R:T58	8.77	Yes	Yes	3	9	7
54	R:R:K326	R:R:T58	4.5	No	Yes	3	6	7
55	R:R:F119	R:R:T60	5.19	Yes	No	0	9	9
56	R:R:K326	R:R:N61	4.2	No	Yes	3	6	9
57	R:R:F327	R:R:N61	9.67	Yes	Yes	3	8	9
58	R:R:A142	R:R:C62	3.61	No	No	0	7	4
59	R:R:C62	R:R:I146	6.55	No	No	0	4	7
60	R:R:F119	R:R:Y63	7.22	Yes	Yes	0	9	8
61	R:R:E122	R:R:Y63	22.45	No	Yes	0	8	8
62	R:R:A142	R:R:Y63	4	No	Yes	0	7	8
63	R:R:F119	R:R:L64	10.96	Yes	No	2	9	8
64	R:R:L64	R:R:Y320	5.86	No	Yes	2	8	9
65	R:R:S115	R:R:S66	6.52	No	No	0	8	9
66	R:R:I146	R:R:S66	7.74	No	No	0	7	9
67	R:R:S66	R:R:W150	3.71	No	Yes	0	9	9
68	R:R:L67	R:R:S115	7.51	No	No	0	9	8
69	R:R:I116	R:R:L67	7.14	No	No	0	8	9
70	R:R:L67	R:R:N316	6.87	No	No	0	9	9
71	R:R:D71	R:R:L75	8.14	No	No	0	9	7
72	R:R:D71	R:R:S313	7.36	No	No	0	9	9
73	R:R:L107	R:R:M73	4.24	Yes	No	6	5	6
74	R:R:M73	R:R:W150	4.65	No	Yes	6	6	9
75	R:R:I109	R:R:V74	4.61	No	No	0	7	7
76	R:R:A78	R:R:Q105	4.55	No	No	1	7	7
77	R:R:L80	R:R:Y93	3.52	No	No	0	8	6
78	R:R:P81	R:R:W91	4.05	No	Yes	0	5	8
79	R:R:I101	R:R:P81	6.77	No	No	0	5	5
80	R:R:P81	R:R:Q105	4.74	No	No	0	5	7
81	R:R:N82	R:R:R306	12.05	No	Yes	1	6	5
82	R:R:N82	R:R:Y310	6.98	No	Yes	1	6	7
83	R:R:T84	R:R:V92	4.76	No	No	0	4	4
84	R:R:T84	R:R:Y93	7.49	No	No	0	4	6
85	R:R:D85	R:R:W91	10.05	No	Yes	0	4	8
86	R:R:I177	R:R:S90	6.19	No	No	0	4	5
87	R:R:W91	R:R:Y93	6.75	Yes	No	0	8	6
88	R:R:C98	R:R:W91	6.53	No	Yes	7	9	8
89	R:R:C179	R:R:W91	18.28	No	Yes	7	9	8
90	R:R:L99	R:R:Y95	4.69	No	No	0	5	3
91	R:R:L166	R:R:Y95	3.52	No	No	0	4	3
92	R:R:C179	R:R:C98	7.28	No	No	7	9	9
93	R:R:F161	R:R:L99	4.87	Yes	No	0	5	5
94	R:R:L164	R:R:L99	4.15	No	No	0	5	5
95	R:R:T102	R:R:W160	7.28	No	Yes	1	4	5
96	R:R:L164	R:R:T102	4.42	No	No	1	5	4
97	R:R:L107	R:R:Y103	3.52	Yes	No	0	5	6
98	R:R:C157	R:R:Y103	6.72	No	No	0	7	6
99	R:R:F161	R:R:Y103	8.25	Yes	No	0	5	6
100	R:R:C157	R:R:Y106	4.03	No	Yes	0	7	5
101	R:R:W160	R:R:Y106	21.22	Yes	Yes	1	5	5
102	R:R:Y106	R:R:Y188	4.96	Yes	Yes	1	5	5
103	R:R:Y106	R:R:Y192	8.94	Yes	Yes	1	5	5
104	R:R:L107	R:R:W150	4.56	Yes	Yes	6	5	9
105	R:R:L107	R:R:S154	7.51	Yes	No	0	5	4
106	R:R:I109	R:R:W279	4.7	No	Yes	0	7	8
107	R:R:I109	R:R:R283	3.76	No	Yes	0	7	6
108	R:R:D195	R:R:N110	12.12	No	No	4	6	6
109	R:R:F199	R:R:N110	21.75	Yes	No	4	5	6
110	R:R:A111	R:R:W150	7.78	No	Yes	0	7	9
111	R:R:F199	R:R:S113	6.61	Yes	No	0	5	7
112	R:R:C114	R:R:F199	8.38	No	Yes	0	5	5
113	R:R:F275	R:R:I116	15.07	Yes	No	2	9	8
114	R:R:I116	R:R:Y320	6.04	No	Yes	2	8	9
115	R:R:P203	R:R:T117	5.25	No	No	0	9	7
116	R:R:F119	R:R:R123	7.48	Yes	Yes	2	9	9
117	R:R:F119	R:R:Y320	7.22	Yes	Yes	2	9	9
118	R:R:C137	R:R:E122	7.6	No	No	0	7	8
119	R:R:R123	R:R:Y211	11.32	Yes	Yes	2	9	9
120	R:R:R123	R:R:Y320	7.2	Yes	Yes	2	9	9
121	R:R:M323	R:R:R123	3.72	No	Yes	2	8	9
122	R:R:C128	R:R:Y124	6.72	Yes	Yes	0	7	8
123	R:R:H129	R:R:Y124	6.53	No	Yes	0	6	8
124	R:R:L210	R:R:Y124	21.1	No	Yes	0	7	8
125	R:R:F213	R:R:Y124	9.28	No	Yes	0	5	8
126	R:R:I127	R:R:I214	5.89	No	Yes	2	9	9
127	R:R:H129	R:R:K132	5.24	No	No	0	6	5
128	R:R:F135	R:R:Q134	4.68	No	No	0	4	6
129	R:R:F139	R:R:K143	4.96	No	No	0	3	4
130	R:R:I145	R:R:R141	6.26	No	No	0	6	5
131	R:R:I145	R:R:K144	4.36	No	No	0	6	3
132	R:R:I191	R:R:L159	4.28	Yes	No	0	7	5
133	R:R:L164	R:R:W160	28.47	No	Yes	1	5	5
134	R:R:W160	R:R:Y181	3.86	Yes	Yes	1	5	4
135	R:R:W160	R:R:Y188	22.19	Yes	Yes	1	5	5
136	R:R:I191	R:R:W160	4.7	Yes	Yes	1	7	5
137	R:R:K182	R:R:L163	9.87	No	No	0	4	4
138	R:R:L163	R:R:Y188	14.07	No	Yes	0	4	5
139	R:R:I177	R:R:L166	4.28	No	No	0	4	4
140	R:R:G180	R:R:N167	5.09	No	No	0	3	1
141	R:R:I168	R:R:I177	4.42	No	No	0	5	4
142	R:R:A174	R:R:Y171	4	No	No	0	4	1
143	R:R:R185	R:R:Y181	18.52	Yes	Yes	1	2	4
144	R:R:Y181	R:R:Y188	9.93	Yes	Yes	1	4	5
145	R:R:Y181	R:R:Y192	3.97	Yes	Yes	1	4	5
146	R:R:I183	R:R:Y187	13.3	No	No	0	2	1
147	R:R:R185	R:R:Y188	4.12	Yes	Yes	1	2	5
148	R:R:N289	R:R:R185	4.82	Yes	Yes	1	4	2
149	R:R:R185	R:R:S290	5.27	Yes	No	0	2	4
150	R:R:N186	R:R:Y187	12.79	No	No	0	2	1
151	R:R:I191	R:R:Y188	21.76	Yes	Yes	1	7	5
152	R:R:Y188	R:R:Y192	11.91	Yes	Yes	1	5	5
153	R:R:P190	R:R:S189	7.13	No	No	0	4	3
154	R:R:I191	R:R:Y192	8.46	Yes	Yes	1	7	5
155	R:R:V286	R:R:Y192	15.14	No	Yes	0	6	5
156	R:R:D195	R:R:F199	5.97	No	Yes	4	6	5
157	R:R:D195	R:R:R283	14.29	No	Yes	4	6	6
158	R:R:F196	R:R:Y200	5.16	No	Yes	0	6	8
159	R:R:F196	R:R:V201	3.93	No	No	0	6	5
160	R:R:G197	R:R:V201	3.68	No	No	0	4	5
161	R:R:F199	R:R:V198	10.49	Yes	No	0	5	5
162	R:R:F199	R:R:R283	4.28	Yes	Yes	4	5	6
163	R:R:W279	R:R:Y200	3.86	Yes	Yes	0	8	8
164	R:R:M280	R:R:Y200	3.59	No	Yes	0	6	8
165	R:R:R283	R:R:Y200	6.17	Yes	Yes	0	6	8
166	R:R:P203	R:R:V202	3.53	No	No	0	9	5
167	R:R:M204	R:R:P203	5.03	No	No	0	6	9
168	R:R:F275	R:R:M204	7.46	Yes	No	0	9	6
169	R:R:A276	R:R:M204	4.83	No	No	0	6	6
170	R:R:T208	R:R:V272	4.76	No	No	0	5	8
171	R:R:I214	R:R:Y211	3.63	Yes	Yes	2	9	9
172	R:R:L268	R:R:Y211	15.24	No	Yes	2	8	9
173	R:R:V272	R:R:Y211	3.79	No	Yes	0	8	9
174	R:R:F213	R:R:R216	7.48	No	No	0	5	4
175	R:R:I214	R:R:L268	4.28	Yes	No	2	9	8
176	R:R:F219	R:R:K262	3.72	No	No	0	5	5
177	R:R:F219	R:R:T265	10.38	No	No	0	5	8
178	R:R:M267	R:R:M323	14.44	No	No	2	9	8
179	R:R:L274	R:R:V270	4.47	No	No	0	6	7
180	R:R:I319	R:R:V271	9.22	No	No	0	8	8
181	R:R:F275	R:R:W279	5.01	Yes	Yes	2	9	8
182	R:R:F275	R:R:N312	9.67	Yes	No	2	9	9
183	R:R:F275	R:R:N316	12.08	Yes	No	2	9	9
184	R:R:F275	R:R:Y320	4.13	Yes	Yes	2	9	9
185	R:R:L278	R:R:N312	15.1	No	No	0	8	9
186	R:R:I309	R:R:W279	8.22	No	Yes	0	6	8
187	R:R:N312	R:R:W279	13.56	No	Yes	2	9	8
188	R:R:M280	R:R:P281	5.03	No	Yes	0	6	9
189	R:R:F304	R:R:P281	5.78	No	Yes	0	4	9
190	R:R:C305	R:R:P281	3.77	No	Yes	0	5	9
191	R:R:C308	R:R:P281	3.77	No	Yes	0	7	9
192	R:R:R283	R:R:Y282	5.14	Yes	Yes	0	6	5
193	R:R:V286	R:R:Y282	6.31	No	Yes	0	6	5
194	R:R:I309	R:R:Y282	7.25	No	Yes	0	6	5
195	R:R:L285	R:R:N289	8.24	No	Yes	0	4	4
196	R:R:L285	R:R:L302	4.15	No	No	0	4	4
197	R:R:C305	R:R:L285	6.35	No	No	0	5	4
198	R:R:N289	R:R:P295	11.4	Yes	No	0	4	1
199	R:R:P295	R:R:Q297	4.74	No	No	0	1	3
200	R:R:E298	R:R:F296	11.66	No	No	0	3	1
201	R:R:E298	R:R:W300	4.36	No	No	0	3	2
202	R:R:E298	R:R:F301	5.83	No	No	0	3	4
203	R:R:N299	R:R:W300	7.91	No	No	5	1	2
204	R:R:F301	R:R:F304	4.29	No	No	0	4	4
205	R:R:C305	R:R:F301	4.19	No	No	0	5	4
206	R:R:L302	R:R:R306	4.86	No	Yes	1	4	5
207	R:R:R306	R:R:Y310	8.23	Yes	Yes	1	5	7
208	R:R:N316	R:R:Y320	4.65	No	Yes	2	9	9
209	R:R:I319	R:R:Y320	10.88	No	Yes	0	8	9
210	R:R:F327	R:R:N321	26.58	Yes	No	0	8	7
211	R:R:P59	R:R:T58	3.5	No	Yes	0	6	7
212	R:R:G108	R:R:M73	3.49	No	No	0	7	6
213	R:R:G39	R:R:L75	3.42	No	No	0	8	7
214	R:R:C114	R:R:V149	3.42	No	No	0	5	7
215	R:R:A68	R:R:V46	3.39	No	No	0	9	9
216	R:R:C128	R:R:I217	3.27	Yes	No	0	7	6
217	R:R:S112	R:R:S313	3.26	No	No	0	9	9
218	R:R:S189	R:R:S290	3.26	No	No	0	3	4
219	R:R:S313	R:R:V74	3.23	No	No	0	9	7
220	R:R:S178	R:R:V176	3.23	No	No	0	4	3
221	R:R:A330	R:R:M56	3.22	No	Yes	0	7	8
222	R:R:V270	R:R:V271	3.21	No	No	0	7	8
223	R:R:S140	R:R:T138	3.2	No	No	0	4	8
224	R:R:T284	R:R:V287	3.17	No	No	0	6	6
225	R:R:A77	R:R:L104	3.15	No	No	0	5	4
226	R:R:M194	R:R:V198	3.04	No	No	0	5	5
227	R:R:L48	R:R:V47	2.98	No	No	0	5	7
228	R:R:L210	R:R:V209	2.98	No	No	0	7	5
229	R:R:L292	R:R:V288	2.98	No	No	0	4	4
230	R:R:L107	R:R:T153	2.95	Yes	No	0	5	8
231	R:R:I29	R:R:I87	2.94	No	No	0	5	5
232	R:R:G180	R:R:Y181	2.9	No	Yes	0	3	4
233	R:R:I121	R:R:L206	2.85	No	No	0	6	6
234	R:R:I183	R:R:L163	2.85	No	No	0	2	4
235	R:R:I205	R:R:L206	2.85	No	No	0	4	6
236	R:R:I315	R:R:L274	2.85	No	No	0	6	6
237	R:R:I307	R:R:L303	2.85	No	No	0	5	4
238	R:R:L277	R:R:M280	2.83	No	No	0	5	6
239	R:R:L278	R:R:L311	2.77	No	No	0	8	5
240	R:R:A118	R:R:Y63	2.67	No	Yes	0	7	8
241	R:R:H55	R:R:M56	2.63	No	Yes	0	5	8
242	R:R:A70	R:R:W150	2.59	No	Yes	0	8	9
243	R:R:V92	R:R:Y88	2.52	No	No	0	4	5
244	R:R:F135	R:R:I131	2.51	No	No	0	4	7
245	R:R:F161	R:R:M158	2.49	Yes	No	0	5	4
246	R:R:K54	R:R:R52	2.48	No	No	0	6	5
247	R:R:S178	R:R:W91	2.47	No	Yes	0	4	8
248	R:R:L136	R:R:R141	2.43	No	No	0	4	5
249	R:R:I125	R:R:Y124	2.42	No	Yes	0	4	8
250	R:R:E122	R:R:R141	2.33	No	No	0	8	5
251	R:R:C98	R:R:G94	1.96	No	No	0	9	7
252	R:R:C100	R:R:G97	1.96	No	No	0	4	5
253	R:R:A314	R:R:G39	1.95	No	No	0	8	8
254	R:R:A215	R:R:G212	1.95	No	No	0	7	3
255	R:R:G42	R:R:V41	1.84	No	No	0	8	4
256	R:R:G97	R:R:V96	1.84	No	No	0	5	2
257	R:R:A133	R:R:C137	1.81	No	No	0	7	7
258	R:R:P295	R:R:S294	1.78	No	No	0	1	2
259	R:R:A174	R:R:V176	1.7	No	No	0	4	3
260	R:R:A207	R:R:V272	1.7	No	No	0	8	8
261	R:R:A215	R:R:T265	1.68	No	No	0	7	8
262	R:R:C100	R:R:I101	1.64	No	No	0	4	5
263	R:R:C128	R:R:I127	1.64	Yes	No	2	7	9
264	R:R:C128	R:R:I214	1.64	Yes	Yes	2	7	9
265	R:R:C62	R:R:K143	1.62	No	No	0	4	4
266	R:R:A77	R:R:I101	1.62	No	No	0	5	5
267	R:R:S169	R:R:V176	1.62	No	No	0	1	3
268	R:R:V287	R:R:V288	1.6	No	No	0	6	4
269	R:R:I175	R:R:S90	1.55	No	No	0	5	5
270	R:R:I44	R:R:V41	1.54	No	No	0	5	4
271	R:R:I44	R:R:V47	1.54	No	No	0	5	7
272	R:R:A174	R:R:D173	1.54	No	No	0	4	3
273	R:R:H129	R:R:P130	1.53	No	No	0	6	8
274	R:R:K326	R:R:S324	1.53	No	No	0	6	8
275	R:R:I121	R:R:T117	1.52	No	No	0	6	7
276	R:R:I175	R:R:T170	1.52	No	No	0	5	1
277	R:R:M267	R:R:V264	1.52	No	No	2	9	8
278	R:R:M323	R:R:V264	1.52	No	No	2	8	8
279	R:R:L38	R:R:V41	1.49	No	No	0	5	4
280	R:R:L193	R:R:V287	1.49	No	No	0	4	6
281	R:R:N289	R:R:V288	1.48	Yes	No	0	4	4
282	R:R:I34	R:R:I35	1.47	No	No	0	4	7
283	R:R:L210	R:R:T120	1.47	No	No	0	7	8
284	R:R:I146	R:R:I147	1.47	No	No	0	7	3
285	R:R:L268	R:R:T265	1.47	No	No	0	8	8
286	R:R:Q25	R:R:V26	1.43	No	No	0	4	5
287	R:R:I29	R:R:L30	1.43	No	No	0	5	4
288	R:R:I83	R:R:L33	1.43	No	No	0	6	3
289	R:R:I127	R:R:L218	1.43	No	No	2	9	8
290	R:R:I214	R:R:L218	1.43	Yes	No	2	9	8
291	R:R:I217	R:R:L218	1.43	No	No	0	6	8
292	R:R:L155	R:R:M158	1.41	No	No	0	4	4
293	R:R:D173	R:R:K172	1.38	No	No	0	3	1
294	R:R:D165	R:R:L166	1.36	No	No	0	5	4
295	R:R:F331	R:R:V49	1.31	No	No	0	7	8
296	R:R:R52	R:R:T53	1.29	No	No	0	5	6
297	R:R:F219	R:R:K266	1.24	No	No	0	5	7
298	R:R:V69	R:R:W150	1.23	No	Yes	0	7	9
299	R:R:F291	R:R:L292	1.22	No	No	0	5	4
300	R:R:I191	R:R:Y156	1.21	Yes	No	0	7	5
301	R:R:L322	R:R:R328	1.21	No	No	0	5	9
302	R:R:F161	R:R:F162	1.07	Yes	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.21667	6	1	0
2	L:L:H2	8.1	5	1	0
3	L:L:P3	5.468	5	1	0
4	R:R:I40	5.33	4	0	6
5	R:R:M56	5.602	5	3	8
6	R:R:T58	5.37	4	3	7
7	R:R:N61	7.984	5	3	9
8	R:R:Y63	9.085	4	0	8
9	R:R:W91	8.02167	6	7	8
10	R:R:Y106	8.918	5	1	5
11	R:R:L107	4.556	5	6	5
12	R:R:F119	7.614	5	2	9
13	R:R:R123	7.43	4	2	9
14	R:R:Y124	9.21	5	0	8
15	R:R:C128	3.3175	4	2	7
16	R:R:W150	4.08667	6	6	9
17	R:R:W160	13.59	7	1	5
18	R:R:F161	4.17	4	0	5
19	R:R:Y181	7.71429	7	1	4
20	R:R:R185	8.366	5	1	2
21	R:R:Y188	12.7057	7	1	5
22	R:R:I191	8.082	5	1	7
23	R:R:Y192	9.684	5	1	5
24	R:R:F199	9.58	6	4	5
25	R:R:Y200	4.695	4	0	8
26	R:R:Y211	8.495	4	2	9
27	R:R:I214	3.374	5	2	9
28	R:R:F275	8.90333	6	2	9
29	R:R:W279	7.07	5	2	8
30	R:R:P281	4.5875	4	0	9
31	R:R:Y282	5.7175	4	0	5
32	R:R:R283	6.728	5	4	6
33	R:R:N289	7.244	5	1	4
34	R:R:R306	9	6	1	5
35	R:R:Y310	7.71	4	1	7
36	R:R:Y320	6.56857	7	2	9
37	R:R:F327	12.585	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R306	37.9255	6.5	Yes	Yes	1	0	5
2	L:L:P3	R:R:R306	44.5772	4.32	Yes	Yes	1	0	5
3	L:L:P3	R:R:Q105	45.6599	11.05	Yes	No	1	0	7
4	L:L:P3	R:R:Y282	56.3188	4.17	Yes	Yes	0	0	5
5	L:L:?1	R:R:N289	20.9072	10.28	Yes	Yes	1	0	4
6	R:R:L285	R:R:N289	17.8769	8.24	No	Yes	0	4	4
7	R:R:C305	R:R:L285	25.9411	6.35	No	No	0	5	4
8	R:R:C305	R:R:F301	17.3854	4.19	No	No	0	5	4
9	R:R:E298	R:R:F301	18.5676	5.83	No	No	0	3	4
10	R:R:E298	R:R:W300	11.1754	4.36	No	No	0	3	2
11	R:R:I309	R:R:Y282	64.3582	7.25	No	Yes	0	6	5
12	R:R:I309	R:R:W279	64.3893	8.22	No	Yes	0	6	8
13	R:R:N312	R:R:W279	12.0901	13.56	No	Yes	2	9	8
14	R:R:L278	R:R:N312	17.1178	15.1	No	No	0	8	9
15	R:R:L278	R:R:L311	15.0208	2.77	No	No	0	8	5
16	R:R:I35	R:R:L311	12.9115	5.71	No	No	0	7	5
17	R:R:R306	R:R:Y310	18.9098	8.23	Yes	Yes	1	5	7
18	R:R:V32	R:R:Y310	13.3657	7.57	No	Yes	1	7	7
19	R:R:I83	R:R:V32	11.5674	4.61	No	No	0	6	7
20	R:R:R283	R:R:Y282	34.1485	5.14	Yes	Yes	0	6	5
21	R:R:I109	R:R:R283	30.5893	3.76	No	Yes	0	7	6
22	R:R:I109	R:R:V74	36.7619	4.61	No	No	0	7	7
23	R:R:S313	R:R:V74	34.864	3.23	No	No	0	9	7
24	R:R:D71	R:R:S313	31.0559	7.36	No	No	0	9	9
25	R:R:D71	R:R:L75	12.2581	8.14	No	No	0	9	7
26	R:R:D71	R:R:N43	18.0511	17.5	No	No	0	9	9
27	R:R:N43	R:R:P317	15.0208	11.4	No	No	0	9	9
28	R:R:F275	R:R:W279	100	5.01	Yes	Yes	2	9	8
29	R:R:F275	R:R:Y320	83.884	4.13	Yes	Yes	2	9	9
30	R:R:F119	R:R:Y320	50.4636	7.22	Yes	Yes	2	9	9
31	R:R:F119	R:R:T60	44.0483	5.19	Yes	No	0	9	9
32	R:R:T58	R:R:T60	42.3931	4.71	Yes	No	0	7	9
33	R:R:N61	R:R:T58	34.9512	8.77	Yes	Yes	3	9	7
34	R:R:F327	R:R:N61	10.1985	9.67	Yes	Yes	3	8	9
35	R:R:N61	R:R:V50	11.8972	8.87	Yes	No	0	9	8
36	R:R:M56	R:R:N61	14.4235	8.41	Yes	Yes	3	8	9
37	L:L:?1	L:L:H2	25.8354	11	Yes	Yes	1	0	0
38	L:L:H2	R:R:Y106	11.2065	5.44	Yes	Yes	1	0	5
39	R:R:C157	R:R:Y106	22.9793	4.03	No	Yes	0	7	5
40	R:R:C157	R:R:Y103	22.4006	6.72	No	No	0	7	6
41	R:R:L107	R:R:Y103	34.3725	3.52	Yes	No	0	5	6
42	R:R:L107	R:R:W150	32.9538	4.56	Yes	Yes	6	5	9
43	R:R:S66	R:R:W150	39.6117	3.71	No	Yes	0	9	9
44	R:R:I146	R:R:S66	14.2928	7.74	No	No	0	7	9
45	R:R:C62	R:R:I146	11.1319	6.55	No	No	0	4	7
46	R:R:A142	R:R:C62	14.5293	3.61	No	No	0	7	4
47	R:R:F119	R:R:Y63	26.7314	7.22	Yes	Yes	0	9	8
48	R:R:A142	R:R:Y63	15.3631	4	No	Yes	0	7	8
49	R:R:S115	R:R:S66	33.352	6.52	No	No	0	8	9
50	R:R:I116	R:R:L67	18.9783	7.14	No	No	0	8	9
51	R:R:L67	R:R:N316	18.9783	6.87	No	No	0	9	9
52	R:R:P81	R:R:Q105	44.0856	4.74	No	No	0	5	7
53	R:R:P81	R:R:W91	31.9209	4.05	No	Yes	0	5	8
54	R:R:I101	R:R:P81	11.8661	6.77	No	No	0	5	5
55	R:R:L164	R:R:L99	38.585	4.15	No	No	0	5	5
56	R:R:L99	R:R:Y95	37.4277	4.69	No	No	0	5	3
57	R:R:L166	R:R:Y95	32.792	3.52	No	No	0	4	3
58	R:R:I177	R:R:L166	23.4833	4.28	No	No	0	4	4
59	R:R:L164	R:R:W160	36.1023	28.47	No	Yes	1	5	5
60	L:L:?1	R:R:Y181	11.4492	5.02	Yes	Yes	1	0	4
61	R:R:W160	R:R:Y181	16.5142	3.86	Yes	Yes	1	5	4
62	R:R:I177	R:R:S90	14.1248	6.19	No	No	0	4	5
63	R:R:F161	R:R:L99	19.0405	4.87	Yes	No	0	5	5
64	R:R:F161	R:R:Y103	21.5046	8.25	Yes	No	0	5	6
65	R:R:R185	R:R:Y188	13.011	4.12	Yes	Yes	1	2	5
66	R:R:F199	R:R:R283	18.5489	4.28	Yes	Yes	4	5	6
67	R:R:F275	R:R:M204	17.5222	7.46	Yes	No	0	9	6
68	R:R:M204	R:R:P203	13.1666	5.03	No	No	0	6	9
69	R:R:E122	R:R:Y63	12.4199	22.45	No	Yes	0	8	8
70	R:R:R123	R:R:Y320	47.8937	7.2	Yes	Yes	2	9	9
71	R:R:R123	R:R:Y211	50.14	11.32	Yes	Yes	2	9	9
72	R:R:I214	R:R:Y211	30.3653	3.63	Yes	Yes	2	9	9
73	R:R:C128	R:R:I214	23.3837	1.64	Yes	Yes	2	7	9
74	R:R:C128	R:R:Y124	19.781	6.72	Yes	Yes	0	7	8
75	R:R:Y181	R:R:Y192	14.0937	3.97	Yes	Yes	1	4	5
76	R:R:L163	R:R:Y188	10.1985	14.07	No	Yes	0	4	5
77	R:R:S178	R:R:W91	13.4279	2.47	No	Yes	0	4	8
78	R:R:S178	R:R:V176	11.4928	3.23	No	No	0	4	3
79	R:R:R185	R:R:S290	10.1487	5.27	Yes	No	0	2	4
80	R:R:V286	R:R:Y192	51.0485	15.14	No	Yes	0	6	5
81	R:R:R283	R:R:Y200	16.8067	6.17	Yes	Yes	0	6	8
82	R:R:C305	R:R:P281	20.677	3.77	No	Yes	0	5	9
83	R:R:M280	R:R:P281	26.2398	5.03	No	Yes	0	6	9
84	R:R:L268	R:R:Y211	13.123	15.24	No	Yes	2	8	9
85	R:R:L268	R:R:T265	12.0901	1.47	No	No	0	8	8
86	R:R:I319	R:R:Y320	10.0429	10.88	No	Yes	0	8	9
87	R:R:N289	R:R:V288	16.4956	1.48	Yes	No	0	4	4
88	R:R:Y106	R:R:Y192	14.9835	8.94	Yes	Yes	1	5	5
89	R:R:V286	R:R:Y282	51.3347	6.31	No	Yes	0	6	5
90	R:R:L67	R:R:S115	35.2001	7.51	No	No	0	9	8
91	R:R:N289	R:R:R185	10.1549	4.82	Yes	Yes	1	4	2
92	R:R:M280	R:R:Y200	27.9821	3.59	No	Yes	0	6	8
93	R:R:Y188	R:R:Y192	15.2013	11.91	Yes	Yes	1	5	5
94	R:R:W279	R:R:Y200	32.2506	3.86	Yes	Yes	0	8	8
95	R:R:I109	R:R:W279	22.2513	4.7	No	Yes	0	7	8
96	R:R:I116	R:R:Y320	11.1319	6.04	No	Yes	2	8	9
97	R:R:N316	R:R:Y320	11.1941	4.65	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y181	5.02	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R185	9.1	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:N289	10.28	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L302	7.4	1	Yes	No	0	4	0	1
L:L:?1	R:R:R306	6.5	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:T102	6.85	1	Yes	No	0	4	0	1
L:L:H2	R:R:Y106	5.44	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:W160	7.41	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:Y181	9.8	1	Yes	Yes	0	4	0	1
L:L:P3	R:R:A78	3.74	1	Yes	No	0	7	0	1
L:L:P3	R:R:Q105	11.05	1	Yes	No	0	7	0	1
L:L:P3	R:R:Y282	4.17	1	Yes	Yes	0	5	0	1
L:L:P3	R:R:R306	4.32	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:N82	10.2	1	No	No	0	6	0	1
L:L:?4	R:R:R306	18.04	1	No	Yes	0	5	0	1
R:R:A78	R:R:Q105	4.55	1	No	No	7	7	1	1
R:R:P81	R:R:Q105	4.74	0	No	No	5	7	2	1
R:R:N82	R:R:R306	12.05	1	No	Yes	6	5	1	1
R:R:N82	R:R:Y310	6.98	1	No	Yes	6	7	1	2
R:R:T102	R:R:W160	7.28	1	No	Yes	4	5	1	1
R:R:L164	R:R:T102	4.42	1	No	No	5	4	2	1
R:R:C157	R:R:Y106	4.03	0	No	Yes	7	5	2	1
R:R:W160	R:R:Y106	21.22	1	Yes	Yes	5	5	1	1
R:R:Y106	R:R:Y188	4.96	1	Yes	Yes	5	5	1	2
R:R:Y106	R:R:Y192	8.94	1	Yes	Yes	5	5	1	2
R:R:L164	R:R:W160	28.47	1	No	Yes	5	5	2	1
R:R:W160	R:R:Y181	3.86	1	Yes	Yes	5	4	1	1
R:R:W160	R:R:Y188	22.19	1	Yes	Yes	5	5	1	2
R:R:I191	R:R:W160	4.7	1	Yes	Yes	7	5	2	1
R:R:R185	R:R:Y181	18.52	1	Yes	Yes	2	4	1	1
R:R:Y181	R:R:Y188	9.93	1	Yes	Yes	4	5	1	2
R:R:Y181	R:R:Y192	3.97	1	Yes	Yes	4	5	1	2
R:R:R185	R:R:Y188	4.12	1	Yes	Yes	2	5	1	2
R:R:N289	R:R:R185	4.82	1	Yes	Yes	4	2	1	1
R:R:R185	R:R:S290	5.27	1	Yes	No	2	4	1	2
R:R:I191	R:R:Y188	21.76	1	Yes	Yes	7	5	2	2
R:R:Y188	R:R:Y192	11.91	1	Yes	Yes	5	5	2	2
R:R:I191	R:R:Y192	8.46	1	Yes	Yes	7	5	2	2
R:R:V286	R:R:Y192	15.14	0	No	Yes	6	5	2	2
R:R:R283	R:R:Y282	5.14	4	Yes	Yes	6	5	2	1
R:R:V286	R:R:Y282	6.31	0	No	Yes	6	5	2	1
R:R:I309	R:R:Y282	7.25	0	No	Yes	6	5	2	1
R:R:L285	R:R:N289	8.24	0	No	Yes	4	4	2	1
R:R:L285	R:R:L302	4.15	0	No	No	4	4	2	1
R:R:N289	R:R:P295	11.4	1	Yes	No	4	1	1	2
R:R:L302	R:R:R306	4.86	1	No	Yes	4	5	1	1
R:R:R306	R:R:Y310	8.23	1	Yes	Yes	5	7	1	2
R:R:G180	R:R:Y181	2.9	0	No	Yes	3	4	2	1
R:R:N289	R:R:V288	1.48	1	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7X1U_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	257
Number of Links	302
Number of Hubs	37
Number of Links mediated by Hubs	143
Number of Communities	7
Number of Nodes involved in Communities	58
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	48997
Length Of Smallest Path	3
Average Path Length	11.8237
Length of Longest Path	24
Minimum Path Strength	1.43
Average Path Strength	6.5435
Maximum Path Strength	25.33
Minimum Path Correlation	0.7
Average Path Correlation	0.920855
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	52.1512
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4935
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• WD40 repeat-like
SCOP2	Family Identifier	• WD40 repeat-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34981
Sequence	>7X1U_nogp_Chain_R Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T K H M R T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G S W V Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H P I K A Q F L C T F S R A K K I I I F V W A F T S L Y C M L W F F L L D L N I S T Y K D A I V I S C G Y K I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L S S P F Q E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R A A F R K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XW9	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.7	2022-12-28	doi.org/10.1038/s41421-022-00477-0
	7XW9 (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		2.7	2022-12-28	doi.org/10.1038/s41421-022-00477-0
	7WKD	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.01	2022-06-15	doi.org/10.1038/s41422-022-00641-x
	7WKD (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.01	2022-06-15	doi.org/10.1038/s41422-022-00641-x
	7X1T	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2022-08-31	doi.org/10.1038/s41422-022-00646-6
	7X1T (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-		3.26	2022-08-31	doi.org/10.1038/s41422-022-00646-6
	7X1U	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.19	2022-08-31	doi.org/10.1038/s41422-022-00646-6
	7X1U (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.19	2022-08-31	doi.org/10.1038/s41422-022-00646-6

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