psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	9.63	Yes	Yes	1	0	0
2	L:L:?1	L:L:P3	3.51	Yes	Yes	1	0	0
3	L:L:?1	R:R:Y106	3.76	Yes	Yes	1	0	5
4	L:L:?1	R:R:Y181	8.78	Yes	Yes	1	0	4
5	L:L:?1	R:R:R185	11.7	Yes	Yes	1	0	2
6	L:L:?1	R:R:Y192	3.76	Yes	Yes	1	0	5
7	L:L:?1	R:R:Y282	6.27	Yes	Yes	1	0	5
8	L:L:?1	R:R:V286	6.37	Yes	No	1	0	6
9	L:L:?1	R:R:N289	7.34	Yes	Yes	1	0	4
10	L:L:?1	R:R:L302	4.44	Yes	No	0	0	4
11	L:L:H2	L:L:P3	4.58	Yes	Yes	1	0	0
12	L:L:H2	R:R:T102	5.48	Yes	Yes	1	0	4
13	L:L:H2	R:R:Q105	3.71	Yes	Yes	1	0	7
14	L:L:H2	R:R:Y106	10.89	Yes	Yes	1	0	5
15	L:L:H2	R:R:L164	6.43	Yes	Yes	1	0	5
16	L:L:H2	R:R:Y181	5.44	Yes	Yes	1	0	4
17	L:L:?4	L:L:P3	12.19	Yes	Yes	1	0	0
18	L:L:P3	R:R:Q105	12.63	Yes	Yes	1	0	7
19	L:L:P3	R:R:Y106	11.13	Yes	Yes	1	0	5
20	L:L:P3	R:R:I109	3.39	Yes	Yes	1	0	7
21	L:L:P3	R:R:Y282	11.13	Yes	Yes	1	0	5
22	L:L:?4	R:R:A78	3.9	Yes	No	1	0	7
23	L:L:?4	R:R:Q105	9.88	Yes	Yes	1	0	7
24	L:L:?4	R:R:Y310	8.7	Yes	Yes	1	0	7
25	R:R:K172	R:R:Q15	6.78	No	No	0	1	5
26	R:R:R17	R:R:Y171	9.26	No	Yes	0	3	1
27	R:R:A174	R:R:R17	4.15	No	No	0	4	3
28	R:R:V20	R:R:Y24	6.31	No	Yes	0	3	2
29	R:R:Q25	R:R:V20	5.73	No	No	0	4	3
30	R:R:T28	R:R:Y24	7.49	No	Yes	3	5	2
31	R:R:N299	R:R:Y24	10.47	No	Yes	0	1	2
32	R:R:L303	R:R:Y24	9.38	No	Yes	3	4	2
33	R:R:Q25	R:R:S86	4.33	No	No	0	4	4
34	R:R:L30	R:R:V26	4.47	No	No	0	4	5
35	R:R:L303	R:R:T28	4.42	No	No	3	4	5
36	R:R:I29	R:R:I83	4.42	No	Yes	0	5	6
37	R:R:I29	R:R:S86	6.19	No	No	0	5	4
38	R:R:I307	R:R:L31	5.71	No	No	0	5	4
39	R:R:I83	R:R:L33	4.28	Yes	No	0	6	3
40	R:R:I35	R:R:L311	5.71	No	No	0	7	5
41	R:R:C36	R:R:L75	3.17	No	No	0	6	7
42	R:R:I40	R:R:L72	4.28	Yes	No	0	6	7
43	R:R:I40	R:R:L75	4.28	Yes	No	0	6	7
44	R:R:D71	R:R:N43	6.73	Yes	Yes	0	9	9
45	R:R:L72	R:R:N43	5.49	No	Yes	0	7	9
46	R:R:N43	R:R:P317	9.77	Yes	No	0	9	9
47	R:R:F331	R:R:M45	9.95	No	No	0	7	7
48	R:R:N321	R:R:V46	8.87	No	No	2	7	9
49	R:R:F327	R:R:V46	5.24	Yes	No	2	8	9
50	R:R:F327	R:R:V49	10.49	Yes	Yes	0	8	8
51	R:R:M56	R:R:V50	4.56	No	No	0	8	8
52	R:R:V50	R:R:V65	3.21	No	No	0	8	6
53	R:R:A330	R:R:T53	3.36	No	No	0	7	6
54	R:R:H55	R:R:R57	9.03	No	No	0	5	8
55	R:R:M56	R:R:N61	9.82	No	No	0	8	9
56	R:R:K326	R:R:M56	4.32	No	No	0	6	8
57	R:R:P59	R:R:T58	3.5	No	No	0	6	7
58	R:R:T58	R:R:T60	3.14	No	No	0	7	9
59	R:R:N61	R:R:T58	8.77	No	No	0	9	7
60	R:R:F119	R:R:T60	7.78	Yes	No	0	9	9
61	R:R:C62	R:R:F139	4.19	No	No	0	4	3
62	R:R:A142	R:R:C62	3.61	No	No	0	7	4
63	R:R:C62	R:R:I146	3.27	No	No	0	4	7
64	R:R:A118	R:R:Y63	4	No	Yes	0	7	8
65	R:R:F119	R:R:Y63	9.28	Yes	Yes	0	9	8
66	R:R:E122	R:R:Y63	15.71	No	Yes	0	8	8
67	R:R:A142	R:R:Y63	5.34	No	Yes	0	7	8
68	R:R:I145	R:R:Y63	6.04	No	Yes	0	6	8
69	R:R:I146	R:R:Y63	4.84	No	Yes	0	7	8
70	R:R:F119	R:R:L64	6.09	Yes	No	2	9	8
71	R:R:L64	R:R:Y320	4.69	No	Yes	2	8	9
72	R:R:L64	R:R:N321	8.24	No	No	2	8	7
73	R:R:I146	R:R:S66	10.84	No	No	0	7	9
74	R:R:D71	R:R:L67	4.07	Yes	Yes	2	9	9
75	R:R:I116	R:R:L67	7.14	No	Yes	0	8	9
76	R:R:L67	R:R:N316	4.12	Yes	Yes	2	9	9
77	R:R:A70	R:R:S112	3.42	No	No	0	8	9
78	R:R:D71	R:R:S112	4.42	Yes	No	0	9	9
79	R:R:D71	R:R:S313	7.36	Yes	No	0	9	9
80	R:R:D71	R:R:N316	8.08	Yes	Yes	2	9	9
81	R:R:L107	R:R:M73	5.65	Yes	No	0	5	6
82	R:R:G108	R:R:M73	3.49	No	No	0	7	6
83	R:R:S313	R:R:V74	6.46	No	No	0	9	7
84	R:R:A77	R:R:L104	3.15	No	No	0	5	4
85	R:R:A78	R:R:Q105	4.55	No	Yes	1	7	7
86	R:R:G79	R:R:N82	3.39	No	No	1	7	6
87	R:R:G79	R:R:Y310	5.79	No	Yes	1	7	7
88	R:R:N82	R:R:R306	3.62	No	No	1	6	5
89	R:R:N82	R:R:Y310	8.14	No	Yes	1	6	7
90	R:R:T84	R:R:V92	3.17	No	No	0	4	4
91	R:R:T84	R:R:Y93	9.99	No	Yes	0	4	6
92	R:R:D85	R:R:W91	5.58	No	Yes	0	4	8
93	R:R:V92	R:R:Y88	3.79	No	No	0	4	5
94	R:R:S90	R:R:V176	3.23	No	No	0	5	3
95	R:R:W91	R:R:Y93	17.36	Yes	Yes	0	8	6
96	R:R:C98	R:R:W91	3.92	Yes	Yes	1	9	8
97	R:R:I101	R:R:W91	3.52	No	Yes	0	5	8
98	R:R:L166	R:R:W91	3.42	Yes	Yes	1	4	8
99	R:R:C179	R:R:W91	6.53	No	Yes	1	9	8
100	R:R:L99	R:R:Y95	7.03	No	Yes	0	5	3
101	R:R:D165	R:R:Y95	4.6	No	Yes	0	5	3
102	R:R:L166	R:R:Y95	4.69	Yes	Yes	0	4	3
103	R:R:K182	R:R:Y95	3.58	No	Yes	0	4	3
104	R:R:C98	R:R:T102	3.38	Yes	Yes	1	9	4
105	R:R:C98	R:R:L164	3.17	Yes	Yes	1	9	5
106	R:R:C179	R:R:C98	7.28	No	Yes	1	9	9
107	R:R:F161	R:R:L99	3.65	Yes	No	0	5	5
108	R:R:I101	R:R:Q105	4.12	No	Yes	0	5	7
109	R:R:Q105	R:R:T102	5.67	Yes	Yes	1	7	4
110	R:R:L164	R:R:T102	11.79	Yes	Yes	1	5	4
111	R:R:L104	R:R:Y103	3.52	No	Yes	0	4	6
112	R:R:L107	R:R:Y103	4.69	Yes	Yes	4	5	6
113	R:R:C157	R:R:Y103	5.38	No	Yes	4	7	6
114	R:R:F161	R:R:Y103	14.44	Yes	Yes	0	5	6
115	R:R:I109	R:R:Y106	3.63	Yes	Yes	1	7	5
116	R:R:W160	R:R:Y106	33.76	Yes	Yes	1	5	5
117	R:R:Y106	R:R:Y192	3.97	Yes	Yes	1	5	5
118	R:R:L107	R:R:S154	4.5	Yes	No	0	5	4
119	R:R:C157	R:R:L107	6.35	No	Yes	4	7	5
120	R:R:I109	R:R:N110	5.66	Yes	Yes	1	7	6
121	R:R:I109	R:R:W279	3.52	Yes	Yes	0	7	8
122	R:R:D195	R:R:N110	5.39	No	Yes	1	6	6
123	R:R:F199	R:R:N110	19.33	Yes	Yes	1	5	6
124	R:R:N110	R:R:R283	3.62	Yes	Yes	1	6	6
125	R:R:A111	R:R:W150	7.78	No	No	0	7	9
126	R:R:F199	R:R:S113	3.96	Yes	No	0	5	7
127	R:R:C114	R:R:V149	6.83	No	No	0	5	7
128	R:R:I116	R:R:Y320	4.84	No	Yes	0	8	9
129	R:R:P203	R:R:T117	5.25	No	No	0	9	7
130	R:R:F119	R:R:R123	12.83	Yes	No	2	9	9
131	R:R:F119	R:R:Y320	4.13	Yes	Yes	2	9	9
132	R:R:T120	R:R:Y211	9.99	No	Yes	0	8	9
133	R:R:C137	R:R:E122	4.56	No	No	0	7	8
134	R:R:E122	R:R:R141	6.98	No	Yes	0	8	5
135	R:R:R123	R:R:Y211	8.23	No	Yes	0	9	9
136	R:R:R123	R:R:Y320	4.12	No	Yes	2	9	9
137	R:R:C128	R:R:Y124	6.72	Yes	Yes	5	7	8
138	R:R:H129	R:R:Y124	6.53	Yes	Yes	5	6	8
139	R:R:L210	R:R:Y124	17.58	No	Yes	0	7	8
140	R:R:F213	R:R:Y124	4.13	No	Yes	0	5	8
141	R:R:I127	R:R:I214	10.3	No	Yes	0	9	9
142	R:R:C128	R:R:H129	4.42	Yes	Yes	5	7	6
143	R:R:H129	R:R:K132	7.86	Yes	No	0	6	5
144	R:R:F135	R:R:I131	5.02	No	No	0	4	7
145	R:R:L136	R:R:R141	4.86	No	Yes	0	4	5
146	R:R:I145	R:R:R141	6.26	No	Yes	0	6	5
147	R:R:F148	R:R:K144	4.96	No	No	0	3	3
148	R:R:M194	R:R:Y156	4.79	No	No	0	5	5
149	R:R:L164	R:R:W160	5.69	Yes	Yes	1	5	5
150	R:R:W160	R:R:Y188	3.86	Yes	Yes	0	5	5
151	R:R:I191	R:R:W160	3.52	No	Yes	0	7	5
152	R:R:W160	R:R:Y192	7.72	Yes	Yes	1	5	5
153	R:R:L163	R:R:Y188	11.72	No	Yes	0	4	5
154	R:R:D165	R:R:N167	4.04	No	No	0	5	1
155	R:R:C179	R:R:L166	3.17	No	Yes	1	9	4
156	R:R:G180	R:R:N167	3.39	No	No	0	3	1
157	R:R:I168	R:R:T170	4.56	No	No	0	5	1
158	R:R:I175	R:R:T170	7.6	No	No	0	5	1
159	R:R:D173	R:R:Y171	3.45	No	Yes	0	3	1
160	R:R:V176	R:R:Y171	3.79	No	Yes	0	3	1
161	R:R:R185	R:R:Y181	15.43	Yes	Yes	1	2	4
162	R:R:Y181	R:R:Y188	12.91	Yes	Yes	0	4	5
163	R:R:Y181	R:R:Y192	5.96	Yes	Yes	1	4	5
164	R:R:I183	R:R:Y187	3.63	No	No	0	2	1
165	R:R:I183	R:R:Y188	6.04	No	Yes	0	2	5
166	R:R:N186	R:R:S184	7.45	No	No	0	2	4
167	R:R:R185	R:R:Y192	7.2	Yes	Yes	1	2	5
168	R:R:N289	R:R:R185	6.03	Yes	Yes	1	4	2
169	R:R:N186	R:R:Y187	6.98	No	No	0	2	1
170	R:R:S189	R:R:S290	6.52	No	No	6	3	4
171	R:R:F291	R:R:S189	11.89	No	No	6	5	3
172	R:R:V286	R:R:Y192	10.09	No	Yes	1	6	5
173	R:R:L193	R:R:V287	4.47	No	No	0	4	6
174	R:R:D195	R:R:F199	7.17	No	Yes	1	6	5
175	R:R:D195	R:R:R283	11.91	No	Yes	1	6	6
176	R:R:F196	R:R:Y200	6.19	Yes	No	0	6	8
177	R:R:F196	R:R:V201	3.93	Yes	No	0	6	5
178	R:R:F196	R:R:V287	3.93	Yes	No	0	6	6
179	R:R:F199	R:R:V198	11.8	Yes	No	0	5	5
180	R:R:F199	R:R:R283	3.21	Yes	Yes	1	5	6
181	R:R:M204	R:R:Y200	4.79	No	No	0	6	8
182	R:R:M280	R:R:Y200	4.79	No	No	0	6	8
183	R:R:P203	R:R:V202	5.3	No	No	0	9	5
184	R:R:F275	R:R:P203	5.78	No	No	0	9	9
185	R:R:A276	R:R:M204	3.22	No	No	0	6	6
186	R:R:L206	R:R:L210	4.15	No	No	0	6	7
187	R:R:T208	R:R:V209	3.17	No	No	0	5	5
188	R:R:F213	R:R:V209	3.93	No	No	0	5	5
189	R:R:L268	R:R:Y211	12.89	No	Yes	0	8	9
190	R:R:V272	R:R:Y211	3.79	No	Yes	0	8	9
191	R:R:F213	R:R:R216	3.21	No	No	0	5	4
192	R:R:L218	R:R:R261	7.29	No	No	0	8	7
193	R:R:F219	R:R:T265	7.78	No	No	0	5	8
194	R:R:S260	R:R:T257	3.2	No	No	0	7	5
195	R:R:R261	R:R:S260	6.59	No	No	0	7	7
196	R:R:K266	R:R:Q263	4.07	No	No	0	7	8
197	R:R:F275	R:R:W279	10.02	No	Yes	0	9	8
198	R:R:C308	R:R:L278	3.17	No	No	0	7	8
199	R:R:L278	R:R:N312	5.49	No	No	0	8	9
200	R:R:R283	R:R:W279	7	Yes	Yes	0	6	8
201	R:R:N312	R:R:W279	9.04	No	Yes	0	9	8
202	R:R:M280	R:R:P281	5.03	No	No	0	6	9
203	R:R:F304	R:R:P281	4.33	No	No	0	4	9
204	R:R:C305	R:R:P281	3.77	No	No	0	5	9
205	R:R:V286	R:R:Y282	8.83	No	Yes	1	6	5
206	R:R:I309	R:R:Y282	7.25	No	Yes	0	6	5
207	R:R:L285	R:R:N289	5.49	No	Yes	0	4	4
208	R:R:F301	R:R:L285	4.87	No	No	0	4	4
209	R:R:C305	R:R:L285	3.17	No	No	0	5	4
210	R:R:L292	R:R:V288	4.47	No	No	0	4	4
211	R:R:N289	R:R:P295	8.15	Yes	No	0	4	1
212	R:R:F291	R:R:S290	5.28	No	No	6	5	4
213	R:R:S293	R:R:S294	3.26	No	No	0	4	2
214	R:R:E298	R:R:F296	11.66	No	No	0	3	1
215	R:R:F296	R:R:F301	6.43	No	No	0	1	4
216	R:R:E298	R:R:W300	4.36	No	No	0	3	2
217	R:R:L302	R:R:R306	3.64	No	No	0	4	5
218	R:R:C308	R:R:F304	5.59	No	No	0	7	4
219	R:R:R306	R:R:Y310	6.17	No	Yes	1	5	7
220	R:R:I309	R:R:Y310	4.84	No	Yes	0	6	7
221	R:R:N312	R:R:N316	6.81	No	Yes	0	9	9
222	R:R:N316	R:R:Y320	3.49	Yes	Yes	2	9	9
223	R:R:I319	R:R:Y320	6.04	Yes	Yes	2	8	9
224	R:R:F327	R:R:N321	13.29	Yes	No	2	8	7
225	R:R:F327	R:R:L322	4.87	Yes	No	0	8	5
226	R:R:Q325	R:R:R328	3.5	No	No	0	5	9
227	R:R:C335	R:R:F331	5.59	No	No	0	6	7
228	R:R:A68	R:R:N43	3.13	No	Yes	0	9	9
229	R:R:I177	R:R:S90	3.1	No	No	0	4	5
230	R:R:K262	R:R:V258	3.04	No	No	0	5	4
231	R:R:A21	R:R:E23	3.02	No	No	0	7	2
232	R:R:F196	R:R:G197	3.01	Yes	No	0	6	4
233	R:R:L67	R:R:S115	3	Yes	No	0	9	8
234	R:R:L31	R:R:V32	2.98	No	No	0	4	7
235	R:R:L80	R:R:V76	2.98	No	No	0	8	4
236	R:R:L218	R:R:V264	2.98	No	No	0	8	8
237	R:R:L274	R:R:V270	2.98	No	No	0	6	7
238	R:R:L107	R:R:T153	2.95	Yes	No	0	5	8
239	R:R:I40	R:R:I44	2.94	Yes	No	0	6	5
240	R:R:I83	R:R:I87	2.94	Yes	No	0	6	5
241	R:R:I168	R:R:I177	2.94	No	No	0	5	4
242	R:R:I315	R:R:I319	2.94	No	Yes	2	6	8
243	R:R:K266	R:R:M267	2.88	No	No	0	7	9
244	R:R:I34	R:R:L38	2.85	No	No	0	4	5
245	R:R:I44	R:R:L48	2.85	No	No	0	5	5
246	R:R:I83	R:R:L80	2.85	Yes	No	0	6	8
247	R:R:I121	R:R:L206	2.85	No	No	0	6	6
248	R:R:I191	R:R:L159	2.85	No	No	0	7	5
249	R:R:I177	R:R:L166	2.85	No	Yes	0	4	4
250	R:R:I214	R:R:L218	2.85	Yes	No	0	9	8
251	R:R:I214	R:R:L268	2.85	Yes	No	0	9	8
252	R:R:I273	R:R:L277	2.85	No	No	0	5	5
253	R:R:I307	R:R:L311	2.85	No	No	0	5	5
254	R:R:I315	R:R:L311	2.85	No	No	0	6	5
255	R:R:C114	R:R:F199	2.79	No	Yes	0	5	5
256	R:R:P81	R:R:Y93	2.78	No	Yes	0	5	6
257	R:R:A215	R:R:F219	2.77	No	No	0	7	5
258	R:R:L302	R:R:Q297	2.66	No	No	0	4	3
259	R:R:F331	R:R:V49	2.62	No	Yes	0	7	8
260	R:R:D173	R:R:Q15	2.61	No	No	0	3	5
261	R:R:A70	R:R:W150	2.59	No	No	0	8	9
262	R:R:V271	R:R:Y320	2.52	No	Yes	0	8	9
263	R:R:V69	R:R:W150	2.45	No	No	0	7	9
264	R:R:F291	R:R:L193	2.44	No	No	0	5	4
265	R:R:L334	R:R:R52	2.43	No	No	0	6	5
266	R:R:I191	R:R:Y156	2.42	No	No	0	7	5
267	R:R:A314	R:R:G39	1.95	No	No	0	8	8
268	R:R:A215	R:R:G212	1.95	No	No	0	7	3
269	R:R:G42	R:R:V41	1.84	No	No	0	8	4
270	R:R:G97	R:R:V96	1.84	No	No	0	5	2
271	R:R:A133	R:R:C137	1.81	No	No	0	7	7
272	R:R:A126	R:R:A133	1.79	No	No	0	8	7
273	R:R:P190	R:R:S189	1.78	No	No	0	4	3
274	R:R:P295	R:R:S294	1.78	No	No	0	1	2
275	R:R:G37	R:R:I40	1.76	No	Yes	0	5	6
276	R:R:G42	R:R:M45	1.75	No	No	0	8	7
277	R:R:G39	R:R:L38	1.71	No	No	0	8	5
278	R:R:G39	R:R:L75	1.71	No	No	0	8	7
279	R:R:A68	R:R:V47	1.7	No	No	0	9	7
280	R:R:A330	R:R:V49	1.7	No	Yes	0	7	8
281	R:R:A77	R:R:V76	1.7	No	No	0	5	4
282	R:R:A207	R:R:V272	1.7	No	No	0	8	8
283	R:R:L14	R:R:P16	1.64	No	No	0	7	4
284	R:R:C137	R:R:I125	1.64	No	No	0	7	4
285	R:R:C128	R:R:I214	1.64	Yes	Yes	0	7	9
286	R:R:C128	R:R:I217	1.64	Yes	No	0	7	6
287	R:R:S178	R:R:V176	1.62	No	No	0	4	3
288	R:R:D173	R:R:P16	1.61	No	No	0	3	4
289	R:R:S140	R:R:T138	1.6	No	No	0	4	8
290	R:R:S259	R:R:T257	1.6	No	No	0	4	5
291	R:R:T265	R:R:V264	1.59	No	No	0	8	8
292	R:R:C335	R:R:N336	1.57	No	No	0	6	4
293	R:R:I205	R:R:V209	1.54	No	No	0	4	5
294	R:R:I319	R:R:V318	1.54	Yes	No	0	8	7
295	R:R:H129	R:R:P130	1.53	Yes	No	0	6	8
296	R:R:M51	R:R:V47	1.52	No	No	0	4	7
297	R:R:M51	R:R:V50	1.52	No	No	0	4	8
298	R:R:M267	R:R:V270	1.52	No	No	0	9	7
299	R:R:M323	R:R:V318	1.52	No	No	0	8	7
300	R:R:L31	R:R:V27	1.49	No	No	0	4	5
301	R:R:L334	R:R:V49	1.49	No	Yes	0	6	8
302	R:R:G94	R:R:Y93	1.45	No	Yes	0	7	6
303	R:R:G97	R:R:Y93	1.45	No	Yes	0	5	6
304	R:R:I147	R:R:K143	1.45	No	No	0	3	4
305	R:R:Q25	R:R:V26	1.43	No	No	0	4	5
306	R:R:I315	R:R:L274	1.43	No	No	2	6	6
307	R:R:I319	R:R:L274	1.43	Yes	No	2	8	6
308	R:R:A151	R:R:F152	1.39	No	No	0	4	3
309	R:R:A329	R:R:R332	1.38	No	No	0	5	5
310	R:R:L292	R:R:N289	1.37	No	Yes	0	4	4
311	R:R:K262	R:R:Q263	1.36	No	No	0	5	8
312	R:R:F327	R:R:S324	1.32	Yes	No	0	8	8
313	R:R:F196	R:R:T284	1.3	Yes	No	0	6	6
314	R:R:R141	R:R:T138	1.29	Yes	No	0	5	8
315	R:R:S169	R:R:Y171	1.27	No	Yes	0	1	1
316	R:R:F148	R:R:I147	1.26	No	No	0	3	3
317	R:R:F161	R:R:M158	1.24	Yes	No	0	5	4
318	R:R:F152	R:R:L155	1.22	No	No	0	3	4
319	R:R:F161	R:R:F162	1.07	Yes	No	0	5	5
320	R:R:R328	R:R:R332	1.07	No	No	0	9	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.556	10	1	0
2	L:L:H2	6.59429	7	1	0
3	L:L:P3	8.36571	7	1	0
4	L:L:?4	8.6675	4	1	0
5	R:R:Y24	8.4125	4	3	2
6	R:R:I40	3.315	4	0	6
7	R:R:N43	6.28	4	0	9
8	R:R:V49	4.075	4	0	8
9	R:R:Y63	7.535	6	0	8
10	R:R:L67	4.5825	4	2	9
11	R:R:D71	6.132	5	2	9
12	R:R:I83	3.6225	4	0	6
13	R:R:W91	6.72167	6	1	8
14	R:R:Y93	6.606	5	0	6
15	R:R:Y95	4.975	4	0	3
16	R:R:C98	4.4375	4	1	9
17	R:R:T102	6.58	4	1	4
18	R:R:Y103	7.0075	4	4	6
19	R:R:Q105	6.76	6	1	7
20	R:R:Y106	11.19	6	1	5
21	R:R:L107	4.828	5	4	5
22	R:R:I109	4.05	4	1	7
23	R:R:N110	8.5	4	1	6
24	R:R:F119	8.022	5	2	9
25	R:R:Y124	8.74	4	5	8
26	R:R:C128	3.605	4	5	7
27	R:R:H129	5.085	4	5	6
28	R:R:R141	4.8475	4	0	5
29	R:R:W160	10.91	5	1	5
30	R:R:F161	5.1	4	0	5
31	R:R:L164	6.77	4	1	5
32	R:R:L166	3.5325	4	1	4
33	R:R:Y171	4.4425	4	0	1
34	R:R:Y181	9.704	5	1	4
35	R:R:R185	10.09	4	1	2
36	R:R:Y188	8.6325	4	0	5
37	R:R:Y192	6.45	6	1	5
38	R:R:F196	3.672	5	0	6
39	R:R:F199	8.04333	6	1	5
40	R:R:Y211	8.725	4	0	9
41	R:R:I214	4.41	4	0	9
42	R:R:W279	7.395	4	0	8
43	R:R:Y282	8.37	4	1	5
44	R:R:R283	6.435	4	1	6
45	R:R:N289	5.676	5	1	4
46	R:R:Y310	6.728	5	1	7
47	R:R:N316	5.625	4	2	9
48	R:R:I319	2.9875	4	2	8
49	R:R:Y320	4.26143	7	2	9
50	R:R:F327	7.042	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:H2	39.9283	9.63	Yes	Yes	1	0	0
2	L:L:H2	R:R:T102	21.1819	5.48	Yes	Yes	1	0	4
3	L:L:H2	R:R:Q105	10.055	3.71	Yes	Yes	1	0	7
4	L:L:?1	L:L:P3	20.4354	3.51	Yes	Yes	1	0	0
5	L:L:P3	R:R:Q105	51.1511	12.63	Yes	Yes	1	0	7
6	L:L:H2	R:R:L164	21.1319	6.43	Yes	Yes	1	0	5
7	L:L:P3	R:R:I109	62.9452	3.39	Yes	Yes	1	0	7
8	L:L:?1	R:R:Y106	11.8609	3.76	Yes	Yes	1	0	5
9	R:R:I109	R:R:Y106	27.1791	3.63	Yes	Yes	1	7	5
10	R:R:C98	R:R:T102	21.5239	3.38	Yes	Yes	1	9	4
11	R:R:C98	R:R:W91	22.8876	3.92	Yes	Yes	1	9	8
12	R:R:L166	R:R:W91	69.3177	3.42	Yes	Yes	1	4	8
13	R:R:I177	R:R:L166	30.6239	2.85	No	Yes	0	4	4
14	R:R:I177	R:R:S90	23.1337	3.1	No	No	0	4	5
15	R:R:S90	R:R:V176	21.2403	3.23	No	No	0	5	3
16	R:R:V176	R:R:Y171	17.4285	3.79	No	Yes	0	3	1
17	R:R:C98	R:R:L164	28.3135	3.17	Yes	Yes	1	9	5
18	R:R:I101	R:R:Q105	59.2168	4.12	No	Yes	0	5	7
19	R:R:I101	R:R:W91	58.3743	3.52	No	Yes	0	5	8
20	R:R:C179	R:R:C98	23.2547	7.28	No	Yes	1	9	9
21	R:R:C179	R:R:L166	19.3052	3.17	No	Yes	1	9	4
22	R:R:L166	R:R:Y95	60.8975	4.69	Yes	Yes	0	4	3
23	R:R:L99	R:R:Y95	52.2229	7.03	No	Yes	0	5	3
24	R:R:F161	R:R:L99	50.4629	3.65	Yes	No	0	5	5
25	R:R:F161	R:R:Y103	45.133	14.44	Yes	Yes	0	5	6
26	R:R:L104	R:R:Y103	32.4047	3.52	No	Yes	0	4	6
27	R:R:A77	R:R:L104	30.553	3.15	No	No	0	5	4
28	R:R:A77	R:R:V76	28.693	1.7	No	No	0	5	4
29	R:R:L80	R:R:V76	26.8246	2.98	No	No	0	8	4
30	R:R:I83	R:R:L80	24.9479	2.85	Yes	No	0	6	8
31	R:R:I29	R:R:I83	19.2677	4.42	No	Yes	0	5	6
32	R:R:I29	R:R:S86	17.3576	6.19	No	No	0	5	4
33	R:R:Q25	R:R:S86	15.4392	4.33	No	No	0	4	4
34	R:R:I109	R:R:W279	85.5284	3.52	Yes	Yes	0	7	8
35	R:R:N312	R:R:W279	89.7781	9.04	No	Yes	0	9	8
36	R:R:N312	R:R:N316	100	6.81	No	Yes	0	9	9
37	R:R:N316	R:R:Y320	87.1174	3.49	Yes	Yes	2	9	9
38	R:R:I319	R:R:Y320	21.2737	6.04	Yes	Yes	2	8	9
39	R:R:D71	R:R:N316	29.8982	8.08	Yes	Yes	2	9	9
40	R:R:D71	R:R:N43	21.2987	6.73	Yes	Yes	0	9	9
41	R:R:L72	R:R:N43	13.9878	5.49	No	Yes	0	7	9
42	R:R:I40	R:R:L72	12.7575	4.28	Yes	No	0	6	7
43	R:R:L64	R:R:Y320	18.8214	4.69	No	Yes	2	8	9
44	R:R:L64	R:R:N321	22.016	8.24	No	No	2	8	7
45	R:R:F327	R:R:N321	19.4678	13.29	Yes	No	2	8	7
46	R:R:F327	R:R:V49	15.4433	10.49	Yes	Yes	0	8	8
47	R:R:F119	R:R:Y320	28.7138	4.13	Yes	Yes	2	9	9
48	R:R:F119	R:R:Y63	27.7921	9.28	Yes	Yes	0	9	8
49	R:R:W91	R:R:Y93	12.524	17.36	Yes	Yes	0	8	6
50	R:R:W160	R:R:Y106	10.1426	33.76	Yes	Yes	1	5	5
51	R:R:R123	R:R:Y320	33.5474	4.12	No	Yes	2	9	9
52	R:R:R123	R:R:Y211	39.1067	8.23	No	Yes	0	9	9
53	R:R:E122	R:R:Y63	11.0476	15.71	No	Yes	0	8	8
54	R:R:L268	R:R:Y211	34.7902	12.89	No	Yes	0	8	9
55	R:R:I214	R:R:L268	33.61	2.85	Yes	No	0	9	8
56	R:R:C128	R:R:I214	18.7964	1.64	Yes	Yes	0	7	9
57	R:R:C128	R:R:Y124	12.157	6.72	Yes	Yes	5	7	8
58	L:L:?1	R:R:N289	59.0583	7.34	Yes	Yes	1	0	4
59	R:R:L285	R:R:N289	43.8819	5.49	No	Yes	0	4	4
60	R:R:C305	R:R:L285	32.6299	3.17	No	No	0	5	4
61	R:R:C305	R:R:P281	31.4163	3.77	No	No	0	5	9
62	R:R:M280	R:R:P281	33.2179	5.03	No	No	0	6	9
63	R:R:M280	R:R:Y200	30.8992	4.79	No	No	0	6	8
64	R:R:F196	R:R:Y200	23.8927	6.19	Yes	No	0	6	8
65	R:R:F196	R:R:V287	14.4341	3.93	Yes	No	0	6	6
66	R:R:L193	R:R:V287	12.0485	4.47	No	No	0	4	6
67	R:R:I214	R:R:L218	13.5916	2.85	Yes	No	0	9	8
68	R:R:L278	R:R:N312	15.5559	5.49	No	No	0	8	9
69	R:R:C308	R:R:L278	14.4966	3.17	No	No	0	7	8
70	R:R:F304	R:R:P281	14.4007	4.33	No	No	0	4	9
71	R:R:C308	R:R:F304	13.5249	5.59	No	No	0	7	4
72	R:R:F301	R:R:L285	13.9336	4.87	No	No	0	4	4
73	R:R:F296	R:R:F301	10.6389	6.43	No	No	0	1	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y106	3.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y181	8.78	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R185	11.7	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:Y192	3.76	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y282	6.27	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V286	6.37	1	Yes	No	0	6	0	1
L:L:?1	R:R:N289	7.34	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L302	4.44	1	Yes	No	0	4	0	1
L:L:H2	R:R:T102	5.48	1	Yes	Yes	0	4	0	1
L:L:H2	R:R:Q105	3.71	1	Yes	Yes	0	7	0	1
L:L:H2	R:R:Y106	10.89	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:L164	6.43	1	Yes	Yes	0	5	0	1
L:L:H2	R:R:Y181	5.44	1	Yes	Yes	0	4	0	1
L:L:P3	R:R:Q105	12.63	1	Yes	Yes	0	7	0	1
L:L:P3	R:R:Y106	11.13	1	Yes	Yes	0	5	0	1
L:L:P3	R:R:I109	3.39	1	Yes	Yes	0	7	0	1
L:L:P3	R:R:Y282	11.13	1	Yes	Yes	0	5	0	1
L:L:?4	R:R:A78	3.9	1	Yes	No	0	7	0	1
L:L:?4	R:R:Q105	9.88	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:Y310	8.7	1	Yes	Yes	0	7	0	1
R:R:A78	R:R:Q105	4.55	1	No	Yes	7	7	1	1
R:R:G79	R:R:N82	3.39	1	No	No	7	6	2	2
R:R:G79	R:R:Y310	5.79	1	No	Yes	7	7	2	1
R:R:N82	R:R:R306	3.62	1	No	No	6	5	2	2
R:R:N82	R:R:Y310	8.14	1	No	Yes	6	7	2	1
R:R:C98	R:R:T102	3.38	1	Yes	Yes	9	4	2	1
R:R:C98	R:R:L164	3.17	1	Yes	Yes	9	5	2	1
R:R:I101	R:R:Q105	4.12	0	No	Yes	5	7	2	1
R:R:Q105	R:R:T102	5.67	1	Yes	Yes	7	4	1	1
R:R:L164	R:R:T102	11.79	1	Yes	Yes	5	4	1	1
R:R:I109	R:R:Y106	3.63	1	Yes	Yes	7	5	1	1
R:R:W160	R:R:Y106	33.76	1	Yes	Yes	5	5	2	1
R:R:Y106	R:R:Y192	3.97	1	Yes	Yes	5	5	1	1
R:R:I109	R:R:N110	5.66	1	Yes	Yes	7	6	1	2
R:R:I109	R:R:W279	3.52	1	Yes	Yes	7	8	1	2
R:R:L164	R:R:W160	5.69	1	Yes	Yes	5	5	1	2
R:R:W160	R:R:Y188	3.86	1	Yes	Yes	5	5	2	2
R:R:W160	R:R:Y192	7.72	1	Yes	Yes	5	5	2	1
R:R:R185	R:R:Y181	15.43	1	Yes	Yes	2	4	1	1
R:R:Y181	R:R:Y188	12.91	1	Yes	Yes	4	5	1	2
R:R:Y181	R:R:Y192	5.96	1	Yes	Yes	4	5	1	1
R:R:R185	R:R:Y192	7.2	1	Yes	Yes	2	5	1	1
R:R:N289	R:R:R185	6.03	1	Yes	Yes	4	2	1	1
R:R:V286	R:R:Y192	10.09	1	No	Yes	6	5	1	1
R:R:V286	R:R:Y282	8.83	1	No	Yes	6	5	1	1
R:R:I309	R:R:Y282	7.25	0	No	Yes	6	5	2	1
R:R:L285	R:R:N289	5.49	0	No	Yes	4	4	2	1
R:R:N289	R:R:P295	8.15	1	Yes	No	4	1	1	2
R:R:L302	R:R:R306	3.64	0	No	No	4	5	1	2
R:R:R306	R:R:Y310	6.17	1	No	Yes	5	7	2	1
R:R:I309	R:R:Y310	4.84	0	No	Yes	6	7	2	1
R:R:L302	R:R:Q297	2.66	0	No	No	4	3	1	2
R:R:L292	R:R:N289	1.37	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XW9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.14
Number of Linked Nodes	281
Number of Links	320
Number of Hubs	50
Number of Links mediated by Hubs	176
Number of Communities	6
Number of Nodes involved in Communities	54
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	55797
Length Of Smallest Path	3
Average Path Length	13.722
Length of Longest Path	35
Minimum Path Strength	1.155
Average Path Strength	5.68549
Maximum Path Strength	22.445
Minimum Path Correlation	0.7
Average Path Correlation	0.926214
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	50.9483
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.7361
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	5-Pyrrolidone-2-carboxylic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34981
Sequence	>7XW9_nogp_Chain_R Q L Q P R A V V A L E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T K H M R T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G S W V Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H P I K A Q F L C T F S R A K K I I I F V W A F T S L Y C M L W F F L L D L N I S T Y K D A I V I S C G Y K I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L T V S S R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L S S P F Q E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R A A F R K L C N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XW9	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.7	2022-12-28	10.1038/s41421-022-00477-0
	7XW9 (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		2.7	2022-12-28	10.1038/s41421-022-00477-0
	7X1U	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.19	2022-08-31	10.1038/s41422-022-00646-6
	7X1U (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.19	2022-08-31	10.1038/s41422-022-00646-6
	7X1T	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.26	2022-08-31	10.1038/s41422-022-00646-6
	7X1T (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	Taltirelin	-		3.26	2022-08-31	10.1038/s41422-022-00646-6
	7WKD	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.01	2022-06-15	10.1038/s41422-022-00641-x
	7WKD (No Gprot)	A	Peptide	Thyrotropin Releasing Hormone	TRH	Homo sapiens	TRH	-		3.01	2022-06-15	10.1038/s41422-022-00641-x

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