CodeNH2
NameAMINO GROUP
Synonyms
Identifier$l^{2}-azane
FormulaH2 N
Molecular Weight16.023
SMILES[NH2]
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0
Networks37
 missing image

This ligand is also present in the following 37 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F8X A Peptide Cholecystokinin CCKA Homo sapiens NN9056 - - 3 2021-12-29 10.1038/s41589-021-00866-8

A 2D representation of the interactions of NH2 in 7F8X
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Y360 R:R:Y48 4.96 0 Yes No 7 7 1 2
R:R:L90 R:R:Y360 4.69 0 No Yes 8 7 2 1
R:R:C94 R:R:M121 8.1 0 No Yes 7 7 2 1
R:R:M95 R:R:Y360 15.57 0 Yes Yes 7 7 2 1
R:R:L356 R:R:N98 9.61 1 No No 6 7 2 2
R:R:N98 R:R:Y360 15.12 0 No Yes 7 7 2 1
L:L:?6 R:R:M121 4.01 1 Yes Yes 0 7 2 1
L:L:?8 R:R:M121 8.45 1 Yes Yes 0 7 1 1
L:L:?9 R:R:M121 14.09 1 Yes Yes 0 7 0 1
R:R:F198 R:R:Y176 19.6 1 Yes Yes 5 7 2 2
L:L:?7 R:R:Y176 7.89 1 Yes Yes 0 7 1 2
L:L:?8 R:R:Y176 10.01 1 Yes Yes 0 7 1 2
L:L:?7 R:R:F198 4.55 1 Yes Yes 0 5 1 2
R:R:I329 R:R:N333 7.08 1 No Yes 7 7 2 2
R:R:I329 R:R:L356 4.28 1 No No 7 6 2 2
L:L:?8 R:R:I329 3.66 1 Yes No 0 7 1 2
L:L:?8 R:R:F330 10.4 1 Yes Yes 0 7 1 2
L:L:?7 R:R:N333 7.18 1 Yes Yes 0 7 1 2
L:L:?8 R:R:N333 5.86 1 Yes Yes 0 7 1 2
L:L:?8 R:R:L356 4.73 1 Yes No 0 6 1 2
R:R:S359 R:R:Y360 5.09 0 No Yes 7 7 2 1
L:L:?9 R:R:Y360 5.84 1 Yes Yes 0 7 0 1
L:L:?6 L:L:?7 23.47 1 Yes Yes 0 0 2 1
L:L:?6 L:L:?8 11.18 1 Yes Yes 0 0 2 1
L:L:?7 L:L:?8 34.46 1 Yes Yes 0 0 1 1
L:L:?7 L:L:?9 5.16 1 Yes Yes 0 0 1 0
L:L:?8 L:L:?9 20.62 1 Yes Yes 0 0 1 0
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.43
Average Nodes In Shell18.00
Average Hubs In Shell11.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F9Z A Peptide Ghrelin Ghrelin Homo sapiens GHRP-6 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.2 2021-08-18 10.1038/s41467-021-25364-2

A 2D representation of the interactions of NH2 in 7F9Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?2 L:L:?6 9.62 3 Yes Yes 0 0 2 1
L:L:?2 R:R:D99 5.43 3 Yes No 0 6 2 2
L:L:?4 L:L:?5 14.15 3 Yes Yes 0 0 2 1
L:L:?4 L:L:?6 9.62 3 Yes Yes 0 0 2 1
L:L:?5 L:L:?6 28.63 3 Yes Yes 0 0 1 1
L:L:?5 L:L:?7 5.87 3 Yes Yes 0 0 1 0
L:L:?5 R:R:E124 5.64 3 Yes Yes 0 4 1 1
L:L:?5 R:R:L181 11.78 3 Yes No 0 4 1 2
L:L:?5 R:R:P200 6.99 3 Yes No 0 4 1 2
L:L:?5 R:R:M213 12.03 3 Yes No 0 5 1 2
L:L:?5 R:R:R283 27.92 3 Yes Yes 0 6 1 2
L:L:?6 L:L:?7 23.95 3 Yes Yes 0 0 1 0
L:L:?6 R:R:D99 4.71 3 Yes No 0 6 1 2
L:L:?6 R:R:Q120 21.95 3 Yes Yes 0 4 1 1
L:L:?6 R:R:E124 6.9 3 Yes Yes 0 4 1 1
L:L:?6 R:R:I178 4.95 3 Yes No 0 4 1 2
L:L:?7 R:R:Q120 9.95 3 Yes Yes 0 4 0 1
L:L:?7 R:R:E124 13.21 3 Yes Yes 0 4 0 1
R:R:F119 R:R:Q120 4.68 0 Yes Yes 4 4 2 1
R:R:E124 R:R:Y128 4.49 3 Yes No 4 6 1 2
R:R:E124 R:R:I178 6.83 3 Yes No 4 4 1 2
R:R:E124 R:R:R283 5.82 3 Yes Yes 4 6 1 2
R:R:L181 R:R:M213 7.07 3 No No 4 5 2 2
R:R:Q120 R:R:V182 2.87 3 Yes No 4 4 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub4.00
Average Interaction Strength13.24
Average Nodes In Shell16.00
Average Hubs In Shell9.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7M3G C Ion Calcium-sensing CaS Homo sapiens - Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4 - 2.5 2021-06-30 10.1038/s41586-021-03691-0

A 2D representation of the interactions of NH2 in 7M3G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E191 R:R:R172 9.3 2 Yes Yes 3 4 1 2
R:R:R172 W:W:?5 4.86 2 Yes Yes 4 0 2 2
R:R:R172 W:W:?8 5.83 2 Yes Yes 4 0 2 1
R:R:E191 R:R:K225 13.5 2 Yes Yes 3 3 1 1
R:R:E191 W:W:?6 6.36 2 Yes Yes 3 0 1 2
R:R:E191 W:W:?7 13.48 2 Yes Yes 3 0 1 1
R:R:E191 W:W:?8 10.59 2 Yes Yes 3 0 1 1
R:R:E191 W:W:?9 3.3 2 Yes Yes 3 0 1 0
R:R:A194 R:R:K225 3.21 0 No Yes 7 3 2 1
R:R:E229 R:R:K225 9.45 0 No Yes 5 3 2 1
R:R:K225 W:W:?7 10.04 2 Yes Yes 3 0 1 1
R:R:K225 W:W:?9 10.54 2 Yes Yes 3 0 1 0
R:R:E228 W:W:?8 21.19 2 No Yes 3 0 1 1
R:R:E228 W:W:?9 6.6 2 No Yes 3 0 1 0
S:S:E241 W:W:?8 8.47 0 No Yes 5 0 2 1
W:W:?3 W:W:?4 19.14 2 Yes Yes 0 0 2 2
W:W:?3 W:W:?5 3.38 2 Yes Yes 0 0 2 2
W:W:?3 W:W:?6 14.64 2 Yes Yes 0 0 2 2
W:W:?3 W:W:?7 2.87 2 Yes Yes 0 0 2 1
W:W:?4 W:W:?5 14.15 2 Yes Yes 0 0 2 2
W:W:?4 W:W:?6 6.19 2 Yes Yes 0 0 2 2
W:W:?4 W:W:?7 7.88 2 Yes Yes 0 0 2 1
W:W:?5 W:W:?6 15.04 2 Yes Yes 0 0 2 2
W:W:?5 W:W:?7 7.88 2 Yes Yes 0 0 2 1
W:W:?5 W:W:?8 6.19 2 Yes Yes 0 0 2 1
W:W:?6 W:W:?7 15.76 2 Yes Yes 0 0 2 1
W:W:?7 W:W:?8 23.64 2 Yes Yes 0 0 1 1
W:W:?7 W:W:?9 7.02 2 Yes Yes 0 0 1 0
W:W:?8 W:W:?9 13.79 2 Yes Yes 0 0 1 0
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.25
Average Nodes In Shell14.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of NH2 in 7M3G
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D215 S:S:R172 9.53 1 Yes Yes 6 4 2 1
R:R:D215 X:X:?5 4.34 1 Yes Yes 6 0 2 2
R:R:E241 X:X:?8 7.42 1 Yes Yes 5 0 2 1
S:S:L173 S:S:R172 7.29 1 Yes Yes 5 4 2 1
S:S:E191 S:S:R172 8.14 1 Yes Yes 3 4 1 1
S:S:P221 S:S:R172 2.88 1 No Yes 3 4 2 1
S:S:R172 X:X:?5 4.86 1 Yes Yes 4 0 1 2
S:S:R172 X:X:?6 4.86 1 Yes Yes 4 0 1 2
S:S:R172 X:X:?8 7.77 1 Yes Yes 4 0 1 1
S:S:R172 X:X:?9 3.03 1 Yes Yes 4 0 1 0
S:S:L173 S:S:P221 3.28 1 Yes No 5 3 2 2
S:S:E191 S:S:K225 17.55 1 Yes Yes 3 3 1 1
S:S:E191 X:X:?6 8.47 1 Yes Yes 3 0 1 2
S:S:E191 X:X:?7 9.44 1 Yes Yes 3 0 1 1
S:S:E191 X:X:?8 3.18 1 Yes Yes 3 0 1 1
S:S:E191 X:X:?9 6.6 1 Yes Yes 3 0 1 0
S:S:A194 S:S:K225 3.21 0 No Yes 7 3 2 1
S:S:E228 S:S:K225 2.7 1 No Yes 3 3 1 1
S:S:E229 S:S:K225 9.45 0 No Yes 5 3 2 1
S:S:K225 X:X:?7 11.48 1 Yes Yes 3 0 1 1
S:S:K225 X:X:?9 10.54 1 Yes Yes 3 0 1 0
S:S:E228 X:X:?8 9.53 1 No Yes 3 0 1 1
S:S:E228 X:X:?9 3.3 1 No Yes 3 0 1 0
X:X:?3 X:X:?4 16.89 1 Yes Yes 0 0 2 2
X:X:?3 X:X:?6 16.89 1 Yes Yes 0 0 2 2
X:X:?3 X:X:?7 2.87 1 Yes Yes 0 0 2 1
X:X:?4 X:X:?5 15.92 1 Yes Yes 0 0 2 2
X:X:?4 X:X:?6 6.19 1 Yes Yes 0 0 2 2
X:X:?4 X:X:?7 5.63 1 Yes Yes 0 0 2 1
X:X:?4 X:X:?8 4.42 1 Yes Yes 0 0 2 1
X:X:?5 X:X:?6 15.92 1 Yes Yes 0 0 2 2
X:X:?5 X:X:?7 7.88 1 Yes Yes 0 0 2 1
X:X:?5 X:X:?8 8.85 1 Yes Yes 0 0 2 1
X:X:?6 X:X:?7 19.14 1 Yes Yes 0 0 2 1
X:X:?6 X:X:?8 4.42 1 Yes Yes 0 0 2 1
X:X:?7 X:X:?8 20.26 1 Yes Yes 0 0 1 1
X:X:?7 X:X:?9 7.02 1 Yes Yes 0 0 1 0
X:X:?8 X:X:?9 13.79 1 Yes Yes 0 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.38
Average Nodes In Shell17.00
Average Hubs In Shell13.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7P00 A Peptide Tachykinin NK1 Homo sapiens Substance P - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 2.71 2021-12-15 10.1126/sciadv.abk2872

A 2D representation of the interactions of NH2 in 7P00
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N85 R:R:N89 5.45 2 Yes Yes 6 6 1 2
R:R:H108 R:R:N85 8.93 2 Yes Yes 5 6 1 1
R:R:N85 R:R:P112 4.89 2 Yes Yes 6 6 1 2
R:R:M291 R:R:N85 4.21 2 Yes Yes 5 6 2 1
R:R:M295 R:R:N85 4.21 2 Yes Yes 7 6 2 1
L:L:?12 R:R:N85 10.27 2 No Yes 0 6 0 1
R:R:H108 R:R:V88 12.45 2 Yes No 5 5 1 2
R:R:H108 R:R:N89 12.75 2 Yes Yes 5 6 1 2
R:R:M291 R:R:N89 5.61 2 Yes Yes 5 6 2 2
L:L:L10 R:R:N89 6.87 2 Yes Yes 0 6 2 2
R:R:H108 R:R:W98 4.23 2 Yes Yes 5 8 1 2
R:R:H108 R:R:P112 10.68 2 Yes Yes 5 6 1 2
L:L:L10 R:R:H108 5.14 2 Yes Yes 0 5 2 1
L:L:?12 R:R:H108 6.41 2 No Yes 0 5 0 1
R:R:I113 R:R:N109 4.25 2 Yes No 5 5 1 2
L:L:L10 R:R:N109 8.24 2 Yes No 0 5 2 2
R:R:F117 R:R:I113 5.02 0 No Yes 7 5 2 1
R:R:I113 R:R:Q165 5.49 2 Yes Yes 5 6 1 2
L:L:M11 R:R:I113 4.37 2 Yes Yes 0 5 2 1
L:L:?12 R:R:I113 10.67 2 No Yes 0 5 0 1
L:L:M11 R:R:Q165 9.52 2 Yes Yes 0 6 2 2
R:R:M291 R:R:M295 5.78 2 Yes Yes 5 7 2 2
R:R:A162 R:R:I113 3.25 0 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.12
Average Nodes In Shell16.00
Average Hubs In Shell11.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7P02 A Peptide Tachykinin NK1 Homo sapiens Protachykinin-1 - chim(NtGi1-Gs)/Beta1/Gamma2 2.87 2021-12-15 10.1126/sciadv.abk2872

A 2D representation of the interactions of NH2 in 7P02
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N85 R:R:N89 5.45 2 Yes Yes 6 6 1 1
R:R:H108 R:R:N85 7.65 2 Yes Yes 5 6 1 1
R:R:N85 R:R:P112 4.89 2 Yes Yes 6 6 1 2
R:R:M295 R:R:N85 7.01 0 Yes Yes 7 6 2 1
L:L:?12 R:R:N85 10.27 2 Yes Yes 0 6 0 1
R:R:V88 R:R:W98 3.68 2 Yes Yes 5 8 2 2
R:R:H108 R:R:V88 16.61 2 Yes Yes 5 5 1 2
R:R:H108 R:R:N89 12.75 2 Yes Yes 5 6 1 1
R:R:N89 R:R:Y287 8.14 2 Yes Yes 6 5 1 2
R:R:M291 R:R:N89 8.41 2 Yes Yes 5 6 2 1
L:L:L10 R:R:N89 6.87 2 Yes Yes 0 6 1 1
L:L:?12 R:R:N89 3.42 2 Yes Yes 0 6 0 1
R:R:W98 R:R:Y92 12.54 2 Yes Yes 8 4 2 2
L:L:L10 R:R:Y92 4.69 2 Yes Yes 0 4 1 2
R:R:H108 R:R:W98 4.23 2 Yes Yes 5 8 1 2
R:R:C180 R:R:W98 7.84 2 Yes Yes 9 8 2 2
L:L:L10 R:R:W98 3.42 2 Yes Yes 0 8 1 2
R:R:H108 R:R:P112 10.68 2 Yes Yes 5 6 1 2
L:L:L10 R:R:H108 3.86 2 Yes Yes 0 5 1 1
L:L:?12 R:R:H108 3.2 2 Yes Yes 0 5 0 1
R:R:I113 R:R:N109 4.25 2 Yes Yes 5 5 1 2
R:R:C180 R:R:N109 4.72 2 Yes Yes 9 5 2 2
L:L:L10 R:R:N109 9.61 2 Yes Yes 0 5 1 2
R:R:F117 R:R:I113 3.77 0 No Yes 7 5 2 1
R:R:A162 R:R:I113 3.25 0 No Yes 7 5 2 1
R:R:I113 R:R:Q165 8.23 2 Yes Yes 5 6 1 2
L:L:M11 R:R:I113 5.83 2 Yes Yes 0 5 1 1
L:L:?12 R:R:I113 10.67 2 Yes Yes 0 5 0 1
L:L:M11 R:R:Q165 8.16 2 Yes Yes 0 6 1 2
L:L:L10 R:R:C180 4.76 2 Yes Yes 0 9 1 2
L:L:M11 R:R:H197 3.94 2 Yes Yes 0 5 1 2
L:L:M11 R:R:V200 3.04 2 Yes Yes 0 5 1 2
R:R:F264 R:R:F268 12.86 2 Yes Yes 7 6 2 2
L:L:M11 R:R:F264 3.73 2 Yes Yes 0 7 1 2
R:R:F268 R:R:Y287 4.13 2 Yes Yes 6 5 2 2
L:L:M11 R:R:F268 9.95 2 Yes Yes 0 6 1 2
R:R:M291 R:R:Y287 10.78 2 Yes Yes 5 5 2 2
R:R:M291 R:R:M295 5.78 2 Yes Yes 5 7 2 2
L:L:?12 L:L:L10 3.45 2 Yes Yes 0 0 0 1
L:L:?12 L:L:M11 3.52 2 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub6.00
Average Interaction Strength5.75
Average Nodes In Shell23.00
Average Hubs In Shell21.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7QVM A Peptide Vasopressin and oxytocin OT Homo sapiens Oxytocin - chim(NtGi1-Go-CtGq)/Beta1/Gamma2 3.25 2022-08-10 10.1038/s41467-022-31325-0

A 2D representation of the interactions of NH2 in 7QVM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:C1 L:L:C6 7.28 0 No Yes 0 0 2 1
L:L:C6 L:L:G9 3.92 15 Yes No 0 0 1 1
L:L:?10 L:L:C6 3.95 15 Yes Yes 0 0 0 1
L:L:L8 R:R:I312 4.28 0 No No 0 4 2 1
L:L:?10 L:L:G9 4.26 15 Yes No 0 0 0 1
L:L:?10 R:R:E42 9.91 15 Yes No 0 5 0 1
L:L:?10 R:R:I312 3.56 15 Yes No 0 4 0 1
L:L:?10 R:R:L316 3.45 15 Yes No 0 5 0 1
R:R:E42 R:R:L38 6.63 15 No No 5 5 1 2
R:R:E42 R:R:I312 4.1 15 No No 5 4 1 1
R:R:D100 R:R:L316 4.07 0 No No 5 5 2 1
R:R:L316 R:R:M315 2.83 0 No No 5 6 1 2
L:L:C6 L:L:P7 1.88 15 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub1.00
Average Interaction Strength5.03
Average Nodes In Shell12.00
Average Hubs In Shell2.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell8.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7R0C A Peptide Vasopressin and oxytocin V2 Homo sapiens Acyclovir triphosphate - Arrestin2 4.73 2022-09-14 10.1126/sciadv.abo7761

A 2D representation of the interactions of NH2 in 7R0C
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:R8 R:R:R32 10.66 14 No No 0 4 1 1
L:L:?10 R:R:R32 12.11 14 Yes No 0 4 0 1
L:L:?10 R:R:D103 3.38 14 Yes No 0 5 0 1
L:L:R8 R:R:W193 12 14 No No 0 4 1 2
L:L:?10 L:L:R8 3.03 14 Yes No 0 0 0 1
L:L:?10 L:L:G9 4.26 14 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.70
Average Nodes In Shell6.00
Average Hubs In Shell1.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RMG A Peptide Tachykinin NK1 Homo sapiens Substance P - chim(Gs-CtGq)/Beta1/Gamma2 3 2021-11-03 10.1038/s41589-021-00890-8

A 2D representation of the interactions of NH2 in 7RMG
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N85 R:R:N89 6.81 1 Yes Yes 6 6 1 1
R:R:H108 R:R:N85 3.83 1 Yes Yes 5 6 1 1
R:R:N85 R:R:P112 6.52 1 Yes Yes 6 6 1 2
L:L:?12 R:R:N85 10.27 1 Yes Yes 0 6 0 1
R:R:H108 R:R:V88 15.22 1 Yes No 5 5 1 2
R:R:H108 R:R:N89 8.93 1 Yes Yes 5 6 1 1
R:R:N89 R:R:Y287 4.65 1 Yes Yes 6 5 1 2
R:R:M291 R:R:N89 4.21 1 Yes Yes 5 6 2 1
L:L:?12 R:R:N89 10.27 1 Yes Yes 0 6 0 1
R:R:W98 R:R:Y92 12.54 1 Yes Yes 8 4 2 2
R:R:C180 R:R:Y92 4.03 1 Yes Yes 9 4 2 2
L:L:L10 R:R:Y92 4.69 1 Yes Yes 0 4 1 2
R:R:H108 R:R:W98 3.17 1 Yes Yes 5 8 1 2
R:R:C180 R:R:W98 11.75 1 Yes Yes 9 8 2 2
R:R:H108 R:R:P112 6.1 1 Yes Yes 5 6 1 2
L:L:?12 R:R:H108 6.41 1 Yes Yes 0 5 0 1
R:R:C180 R:R:N109 3.15 1 Yes Yes 9 5 2 2
L:L:L10 R:R:N109 10.98 1 Yes Yes 0 5 1 2
R:R:I113 R:R:Q165 5.49 1 Yes Yes 5 6 2 2
L:L:M11 R:R:I113 5.83 1 Yes Yes 0 5 1 2
L:L:M11 R:R:Q165 8.16 1 Yes Yes 0 6 1 2
L:L:L10 R:R:C180 3.17 1 Yes Yes 0 9 1 2
R:R:F264 R:R:F268 13.93 1 Yes No 7 6 2 2
L:L:M11 R:R:F264 3.73 1 Yes Yes 0 7 1 2
L:L:M11 R:R:F268 12.44 1 Yes No 0 6 1 2
R:R:M291 R:R:Y287 4.79 1 Yes Yes 5 5 2 2
L:L:?12 L:L:L10 3.45 1 Yes Yes 0 0 0 1
L:L:?12 L:L:M11 3.52 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.78
Average Nodes In Shell18.00
Average Hubs In Shell16.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RMH A Peptide Tachykinin NK1 Homo sapiens Substance P - Gs/Beta1/Gamma2 3.1 2021-11-03 10.1038/s41589-021-00890-8

A 2D representation of the interactions of NH2 in 7RMH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N85 R:R:N89 5.45 3 Yes Yes 6 6 1 1
R:R:H108 R:R:N85 2.55 3 Yes Yes 5 6 1 1
R:R:N85 R:R:P112 6.52 3 Yes No 6 6 1 2
L:L:?12 R:R:N85 10.27 3 Yes Yes 0 6 0 1
R:R:V88 R:R:W98 2.45 3 Yes Yes 5 8 2 2
R:R:V88 R:R:Y104 5.05 3 Yes Yes 5 5 2 2
R:R:H108 R:R:V88 8.3 3 Yes Yes 5 5 1 2
R:R:H108 R:R:N89 10.2 3 Yes Yes 5 6 1 1
R:R:N89 R:R:Y287 4.65 3 Yes Yes 6 5 1 2
L:L:?12 R:R:N89 10.27 3 Yes Yes 0 6 0 1
R:R:W98 R:R:Y92 8.68 3 Yes Yes 8 4 2 2
L:L:L10 R:R:Y92 4.69 3 Yes Yes 0 4 1 2
R:R:H108 R:R:W98 2.12 3 Yes Yes 5 8 1 2
R:R:C180 R:R:W98 6.53 3 Yes Yes 9 8 2 2
R:R:H108 R:R:Y104 2.18 3 Yes Yes 5 5 1 2
L:L:L10 R:R:H108 2.57 3 Yes Yes 0 5 1 1
L:L:?12 R:R:H108 6.41 3 Yes Yes 0 5 0 1
L:L:L10 R:R:N109 2.75 3 Yes Yes 0 5 1 2
R:R:I113 R:R:Q165 4.12 3 Yes Yes 5 6 2 2
L:L:M11 R:R:I113 4.37 3 Yes Yes 0 5 1 2
L:L:M11 R:R:Q165 4.08 3 Yes Yes 0 6 1 2
L:L:L10 R:R:C180 1.59 3 Yes Yes 0 9 1 2
R:R:F264 R:R:F268 12.86 3 Yes No 7 6 2 2
L:L:M11 R:R:F264 2.49 3 Yes Yes 0 7 1 2
L:L:M11 R:R:F268 8.71 3 Yes No 0 6 1 2
L:L:?12 L:L:L10 3.45 3 Yes Yes 0 0 0 1
L:L:?12 L:L:M11 3.52 3 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.78
Average Nodes In Shell18.00
Average Hubs In Shell16.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RMI A Peptide Tachykinin NK1 Homo sapiens Substance P - chim(Gs-CtGq)/Beta1/Gamma2 3.2 2021-11-03 10.1038/s41589-021-00890-8

A 2D representation of the interactions of NH2 in 7RMI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N85 R:R:N89 9.54 1 Yes Yes 6 6 1 1
R:R:H108 R:R:N85 2.55 1 Yes Yes 5 6 1 1
R:R:N85 R:R:P112 4.89 1 Yes No 6 6 1 2
L:L:?12 R:R:N85 10.27 1 Yes Yes 0 6 0 1
R:R:V88 R:R:W98 3.68 1 Yes Yes 5 8 2 2
R:R:H108 R:R:V88 9.69 1 Yes Yes 5 5 1 2
R:R:H108 R:R:N89 8.93 1 Yes Yes 5 6 1 1
R:R:N89 R:R:Y287 4.65 1 Yes Yes 6 5 1 2
L:L:?12 R:R:N89 10.27 1 Yes Yes 0 6 0 1
R:R:W98 R:R:Y92 13.5 1 Yes Yes 8 4 2 2
L:L:L10 R:R:Y92 4.69 1 Yes Yes 0 4 1 2
R:R:C180 R:R:W98 14.37 1 Yes Yes 9 8 2 2
L:L:L10 R:R:W98 3.42 1 Yes Yes 0 8 1 2
L:L:L10 R:R:H108 5.14 1 Yes Yes 0 5 1 1
L:L:?12 R:R:H108 9.61 1 Yes Yes 0 5 0 1
R:R:I113 R:R:Q165 8.23 1 Yes Yes 5 6 2 2
L:L:M11 R:R:I113 4.37 1 Yes Yes 0 5 1 2
L:L:M11 R:R:Q165 5.44 1 Yes Yes 0 6 1 2
L:L:L10 R:R:C180 3.17 1 Yes Yes 0 9 1 2
L:L:M11 R:R:H197 2.63 1 Yes No 0 5 1 2
R:R:F264 R:R:F268 10.72 1 Yes No 7 6 2 2
L:L:M11 R:R:F264 3.73 1 Yes Yes 0 7 1 2
L:L:M11 R:R:F268 11.2 1 Yes No 0 6 1 2
L:L:?12 L:L:L10 3.45 1 Yes Yes 0 0 0 1
L:L:?12 L:L:M11 3.52 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.42
Average Nodes In Shell17.00
Average Hubs In Shell14.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7RYC A Peptide Vasopressin and oxytocin OT Homo sapiens Oxytocin - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 2.9 2022-03-09 10.1038/s41594-022-00728-4

A 2D representation of the interactions of NH2 in 7RYC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:G9 L:L:L8 1.71 0 No No 0 0 1 2
L:L:?10 L:L:G9 4.26 17 Yes No 0 0 0 1
L:L:?10 R:R:N35 3.42 17 Yes No 0 5 0 1
L:L:?10 R:R:L38 10.35 17 Yes No 0 5 0 1
L:L:?10 R:R:A39 3.93 17 Yes No 0 5 0 1
R:R:A39 R:R:R34 6.91 0 No No 5 5 1 2
R:R:L38 R:R:N35 9.61 17 No No 5 5 1 1
R:R:A37 R:R:L38 1.58 0 No No 3 5 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub0.00
Average Interaction Strength5.49
Average Nodes In Shell8.00
Average Hubs In Shell1.00
Average Links In Shell8.00
Average Links Mediated by Hubs In Shell4.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYF B1 Peptide Calcitonin CT (AMY1) Homo sapiens Amylin - Gs/Beta1/Gamma2; RAMP1 2.2 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?38 L:L:T36 7.35 1 Yes Yes 0 0 0 1
L:L:T36 R:R:W79 4.85 0 Yes Yes 0 6 1 2
L:L:?38 R:R:W128 14.19 1 Yes Yes 0 5 0 1
L:L:?38 R:R:S129 3.74 1 Yes Yes 0 7 0 1
L:L:?38 R:R:Y131 5.84 1 Yes Yes 0 5 0 1
R:R:D77 R:R:L80 4.07 1 Yes Yes 9 5 2 2
R:R:D77 R:R:W82 8.93 1 Yes Yes 9 9 2 2
R:R:D77 R:R:S129 5.89 1 Yes Yes 9 7 2 1
R:R:D77 R:R:Y131 5.75 1 Yes Yes 9 5 2 1
R:R:F102 R:R:W79 4.01 1 Yes Yes 4 6 2 2
R:R:W79 R:R:Y131 23.15 1 Yes Yes 6 5 2 1
R:R:L80 R:R:V108 4.47 1 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 5.86 1 Yes Yes 5 5 2 1
R:R:V108 R:R:W82 3.68 1 Yes Yes 7 9 2 2
R:R:K110 R:R:W82 18.57 1 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 4.94 1 Yes Yes 7 9 1 2
R:R:F102 R:R:Y131 3.09 1 Yes Yes 4 5 2 1
R:R:V108 R:R:Y131 12.62 1 Yes Yes 7 5 2 1
R:R:K110 R:R:S129 9.18 1 Yes Yes 8 7 2 1
R:R:H121 R:R:W128 6.35 1 Yes Yes 4 5 2 1
H:H:?2 R:R:H121 4.59 1 Yes Yes 0 4 2 2
H:H:?2 R:R:W128 10.16 1 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 6.36 1 Yes Yes 7 5 1 1
L:L:G33 R:R:W128 2.81 0 No Yes 0 5 2 1
L:L:N31 L:L:T36 1.46 0 No Yes 0 0 2 1
L:L:N35 L:L:T36 1.46 0 No Yes 0 0 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.78
Average Nodes In Shell17.00
Average Hubs In Shell14.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYH B1 Peptide Calcitonin CT (AMY2) Homo sapiens Calcitonin-1 - Gs/Beta1/Gamma2; RAMP2 3.3 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYH
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?33 L:L:G28 4.26 1 Yes No 0 0 0 1
L:L:G28 R:R:W128 2.81 1 No Yes 0 5 1 1
L:L:A31 L:L:P32 3.74 0 No Yes 0 0 2 1
L:L:?33 L:L:P32 4.09 1 Yes Yes 0 0 0 1
L:L:P32 R:R:D77 4.83 1 Yes Yes 0 9 1 1
L:L:P32 R:R:G78 4.06 1 Yes No 0 5 1 2
L:L:P32 R:R:W79 5.4 1 Yes Yes 0 6 1 2
L:L:?33 R:R:D77 3.38 1 Yes Yes 0 9 0 1
L:L:?33 R:R:W128 2.84 1 Yes Yes 0 5 0 1
L:L:?33 R:R:S129 7.48 1 Yes Yes 0 7 0 1
L:L:?33 R:R:Y131 5.84 1 Yes Yes 0 5 0 1
R:R:D77 R:R:G78 3.35 1 Yes No 9 5 1 2
R:R:D77 R:R:W82 6.7 1 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 2.94 1 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 8.05 1 Yes Yes 9 5 1 1
R:R:W79 R:R:Y131 19.29 0 Yes Yes 6 5 2 1
R:R:K110 R:R:W82 25.53 1 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 3.71 1 Yes Yes 7 9 1 2
R:R:W82 R:R:Y131 2.89 1 Yes Yes 9 5 2 1
R:R:V108 R:R:Y131 5.05 0 No Yes 7 5 2 1
R:R:K110 R:R:S129 9.18 1 Yes Yes 8 7 2 1
R:R:F119 R:R:W128 7.02 0 No Yes 4 5 2 1
R:R:H121 R:R:W128 21.16 1 Yes Yes 4 5 2 1
R:R:N130 R:R:W128 11.3 0 No Yes 8 5 2 1
R:R:S129 R:R:Y131 8.9 1 Yes Yes 7 5 1 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength4.65
Average Nodes In Shell16.00
Average Hubs In Shell10.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYI B1 Peptide Calcitonin CT Homo sapiens Amylin - Gs/Beta1/Gamma2 3.3 2022-03-30 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYI
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:T36 L:L:Y37 4.99 2 No Yes 0 0 1 1
L:L:?38 L:L:T36 7.35 2 No No 0 0 0 1
L:L:?38 L:L:Y37 8.76 2 No Yes 0 0 0 1
L:L:Y37 R:R:G78 8.69 2 Yes No 0 5 1 2
L:L:Y37 R:R:W79 12.54 2 Yes Yes 0 6 1 1
L:L:?38 R:R:W79 11.35 2 No Yes 0 6 0 1
R:R:F99 R:R:W79 9.02 2 Yes Yes 5 6 2 1
R:R:F102 R:R:W79 5.01 2 Yes Yes 4 6 2 1
R:R:W79 R:R:Y131 11.58 2 Yes Yes 6 5 1 2
R:R:F102 R:R:F99 4.29 2 Yes Yes 4 5 2 2
R:R:F102 R:R:Y131 7.22 2 Yes Yes 4 5 2 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.15
Average Nodes In Shell8.00
Average Hubs In Shell5.00
Average Links In Shell11.00
Average Links Mediated by Hubs In Shell10.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYL B1 Peptide Calcitonin CT Homo sapiens Amylin - Gs/Beta1/Gamma2 3.3 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:V32 R:R:W79 4.9 0 No Yes 0 6 2 1
L:L:T36 R:R:W79 6.06 0 No Yes 0 6 2 1
L:L:?38 L:L:Y37 5.84 2 Yes Yes 0 0 0 1
L:L:Y37 R:R:D77 16.09 2 Yes Yes 0 9 1 2
L:L:Y37 R:R:G78 7.24 2 Yes No 0 5 1 2
L:L:Y37 R:R:W79 11.58 2 Yes Yes 0 6 1 1
L:L:?38 R:R:W79 2.84 2 Yes Yes 0 6 0 1
L:L:?38 R:R:W128 8.51 2 Yes No 0 5 0 1
L:L:?38 R:R:Y131 2.92 2 Yes Yes 0 5 0 1
R:R:D77 R:R:G78 6.71 2 Yes No 9 5 2 2
R:R:D77 R:R:W79 3.35 2 Yes Yes 9 6 2 1
R:R:D77 R:R:Y131 8.05 2 Yes Yes 9 5 2 1
R:R:W79 R:R:Y98 6.75 2 Yes Yes 6 4 1 2
R:R:F99 R:R:W79 6.01 2 Yes Yes 5 6 2 1
R:R:F102 R:R:W79 7.02 2 Yes Yes 4 6 2 1
R:R:W79 R:R:Y131 18.33 2 Yes Yes 6 5 1 1
R:R:L80 R:R:Y131 5.86 0 Yes Yes 5 5 2 1
R:R:V108 R:R:W82 6.13 2 Yes Yes 7 9 2 2
R:R:S129 R:R:W82 7.41 2 No Yes 7 9 2 2
R:R:W82 R:R:Y131 6.75 2 Yes Yes 9 5 2 1
R:R:F99 R:R:Y98 14.44 2 Yes Yes 5 4 2 2
R:R:F102 R:R:F99 7.5 2 Yes Yes 4 5 2 2
R:R:V108 R:R:Y131 12.62 2 Yes Yes 7 5 2 1
R:R:H121 R:R:W128 17.98 18 Yes No 4 5 2 1
R:R:N130 R:R:W128 7.91 0 No No 8 5 2 1
R:R:S129 R:R:Y131 6.36 2 No Yes 7 5 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength5.03
Average Nodes In Shell18.00
Average Hubs In Shell12.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYN B1 Peptide Calcitonin CT Homo sapiens Calcitonin-1 - Gs/Beta1/Gamma2 2.6 2022-03-30 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:G28 R:R:W128 4.22 0 No Yes 0 5 2 1
L:L:?33 L:L:P32 12.28 2 Yes No 0 0 0 1
L:L:P32 R:R:W79 21.62 0 No Yes 0 6 1 2
L:L:?33 R:R:W128 5.68 2 Yes Yes 0 5 0 1
L:L:?33 R:R:S129 3.74 2 Yes Yes 0 7 0 1
L:L:?33 R:R:Y131 5.84 2 Yes Yes 0 5 0 1
R:R:D77 R:R:W82 8.93 2 Yes Yes 9 9 2 2
R:R:D77 R:R:K110 4.15 2 Yes Yes 9 8 2 2
R:R:D77 R:R:S129 4.42 2 Yes Yes 9 7 2 1
R:R:D77 R:R:Y131 3.45 2 Yes Yes 9 5 2 1
R:R:F102 R:R:W79 5.01 2 Yes Yes 4 6 2 2
R:R:W79 R:R:Y131 15.43 2 Yes Yes 6 5 2 1
R:R:L80 R:R:Y131 3.52 0 No Yes 5 5 2 1
R:R:V108 R:R:W82 3.68 0 No Yes 7 9 2 2
R:R:K110 R:R:W82 17.4 2 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 4.94 2 Yes Yes 7 9 1 2
R:R:F102 R:R:P96 5.78 2 Yes No 4 9 2 2
R:R:P96 R:R:Y131 4.17 2 No Yes 9 5 2 1
R:R:F102 R:R:Y131 6.19 2 Yes Yes 4 5 2 1
R:R:V108 R:R:Y131 7.57 0 No Yes 7 5 2 1
R:R:K110 R:R:S129 6.12 2 Yes Yes 8 7 2 1
R:R:H121 R:R:W128 11.64 0 No Yes 4 5 2 1
R:R:N130 R:R:W128 5.65 2 Yes Yes 8 5 2 1
H:H:?1 R:R:W128 4.06 2 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 12.72 2 Yes Yes 7 5 1 1
H:H:?1 R:R:N130 24.5 2 Yes Yes 0 8 2 2
L:L:P32 R:R:G78 2.03 0 No No 0 5 1 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.89
Average Nodes In Shell18.00
Average Hubs In Shell11.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYO B1 Peptide Calcitonin CT Homo sapiens Calcitonin - Gs/Beta1/Gamma2 2.7 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?33 L:L:P32 12.28 1 Yes No 0 0 0 1
L:L:P32 R:R:G78 4.06 1 No No 0 5 1 1
L:L:P32 R:R:W79 4.05 1 No Yes 0 6 1 2
L:L:?33 R:R:D77 3.38 1 Yes Yes 0 9 0 1
L:L:?33 R:R:G78 4.26 1 Yes No 0 5 0 1
L:L:?33 R:R:S129 3.74 1 Yes No 0 7 0 1
L:L:?33 R:R:Y131 11.68 1 Yes Yes 0 5 0 1
R:R:D77 R:R:T75 5.78 1 Yes No 9 5 1 2
R:R:D77 R:R:K110 4.15 1 Yes Yes 9 8 1 2
R:R:D77 R:R:T127 8.67 1 Yes No 9 4 1 2
R:R:G78 R:R:W79 5.63 1 No Yes 5 6 1 2
R:R:W79 R:R:Y131 2.89 1 Yes Yes 6 5 2 1
R:R:L80 R:R:Y131 5.86 0 No Yes 5 5 2 1
R:R:F102 R:R:Y131 7.22 1 Yes Yes 4 5 2 1
R:R:V108 R:R:Y131 5.05 0 No Yes 7 5 2 1
R:R:K110 R:R:T127 3 1 Yes No 8 4 2 2
R:R:K110 R:R:S129 10.71 1 Yes No 8 7 2 1
R:R:S129 R:R:Y131 6.36 1 No Yes 7 5 1 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength7.07
Average Nodes In Shell13.00
Average Hubs In Shell6.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYW B1 Peptide Calcitonin CT (AMY1) Homo sapiens Calcitonin-1 - Gs/Beta1/Gamma2; RAMP1 3 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYW
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?33 L:L:P32 12.28 2 Yes Yes 0 0 0 1
L:L:P32 R:R:D77 8.05 2 Yes Yes 0 9 1 1
L:L:P32 R:R:G78 4.06 2 Yes No 0 5 1 2
L:L:P32 R:R:W79 20.27 2 Yes Yes 0 6 1 2
L:L:P32 R:R:Y131 5.56 2 Yes Yes 0 5 1 1
L:L:?33 R:R:D77 6.76 2 Yes Yes 0 9 0 1
L:L:?33 R:R:W128 8.51 2 Yes Yes 0 5 0 1
L:L:?33 R:R:S129 7.48 2 Yes Yes 0 7 0 1
L:L:?33 R:R:Y131 8.76 2 Yes Yes 0 5 0 1
R:R:D77 R:R:G78 5.03 2 Yes No 9 5 1 2
R:R:D77 R:R:W82 8.93 2 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 8.83 2 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 6.9 2 Yes Yes 9 5 1 1
R:R:P96 R:R:W79 4.05 2 Yes Yes 9 6 2 2
R:R:F102 R:R:W79 5.01 2 Yes Yes 4 6 2 2
R:R:W79 R:R:Y131 19.29 2 Yes Yes 6 5 2 1
R:R:V108 R:R:W82 3.68 0 No Yes 7 9 2 2
R:R:K110 R:R:W82 20.89 2 Yes Yes 8 9 2 2
R:R:F102 R:R:P96 5.78 2 Yes Yes 4 9 2 2
R:R:P96 R:R:Y131 4.17 2 Yes Yes 9 5 2 1
R:R:F102 R:R:Y131 3.09 2 Yes Yes 4 5 2 1
R:R:V108 R:R:Y131 6.31 0 No Yes 7 5 2 1
R:R:K110 R:R:S129 6.12 2 Yes Yes 8 7 2 1
R:R:F119 R:R:W128 15.03 2 No Yes 4 5 2 1
H:H:?1 R:R:F119 6.52 2 Yes No 0 4 2 2
R:R:H121 R:R:W128 6.35 0 No Yes 4 5 2 1
R:R:N130 R:R:W128 4.52 2 Yes Yes 8 5 2 1
H:H:?1 R:R:W128 7.11 2 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 7.63 2 Yes Yes 7 5 1 1
H:H:?1 R:R:N130 24.5 2 Yes Yes 0 8 2 2
L:L:P32 L:L:T31 1.75 2 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.76
Average Nodes In Shell18.00
Average Hubs In Shell13.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYX B1 Peptide Calcitonin CT (AMY2) Homo sapiens Amylin - Gs/Beta1/Gamma2; RAMP2 2.55 2022-03-30 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y37 R:R:D77 4.6 1 Yes Yes 0 9 2 1
L:L:Y37 R:R:G78 10.14 1 Yes Yes 0 5 2 2
L:L:?38 R:R:D77 3.38 1 No Yes 0 9 0 1
L:L:?38 R:R:W128 11.35 1 No Yes 0 5 0 1
L:L:?38 R:R:S129 3.74 1 No Yes 0 7 0 1
R:R:D77 R:R:G78 3.35 1 Yes Yes 9 5 1 2
R:R:D77 R:R:W82 4.47 1 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 8.83 1 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 10.34 1 Yes Yes 9 5 1 2
R:R:K110 R:R:W82 16.24 1 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 3.71 1 Yes Yes 7 9 1 2
R:R:K110 R:R:S129 12.24 1 Yes Yes 8 7 2 1
R:R:F119 R:R:W128 4.01 0 No Yes 4 5 2 1
R:R:H121 R:R:W128 19.04 1 Yes Yes 4 5 2 1
R:R:N130 R:R:W128 11.3 1 Yes Yes 8 5 2 1
H:H:?2 R:R:W128 6.1 1 No Yes 0 5 2 1
R:R:S129 R:R:Y131 5.09 1 Yes Yes 7 5 1 2
H:H:?2 R:R:N130 25.72 1 No Yes 0 8 2 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.16
Average Nodes In Shell13.00
Average Hubs In Shell10.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TYY B1 Peptide Calcitonin CT (AMY2) Homo sapiens Calcitonin-1 - Gs/Beta1/Gamma2; RAMP2 3 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TYY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?33 L:L:P32 4.09 2 Yes No 0 0 0 1
L:L:P32 R:R:D77 4.83 2 No Yes 0 9 1 1
L:L:P32 R:R:W79 22.97 2 No Yes 0 6 1 2
L:L:?33 R:R:D77 10.15 2 Yes Yes 0 9 0 1
L:L:?33 R:R:W128 8.51 2 Yes Yes 0 5 0 1
L:L:?33 R:R:S129 7.48 2 Yes Yes 0 7 0 1
R:R:D77 R:R:W82 6.7 2 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 7.36 2 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 8.05 2 Yes Yes 9 5 1 2
R:R:W79 R:R:Y131 13.5 2 Yes Yes 6 5 2 2
R:R:K110 R:R:W82 20.89 2 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 7.41 2 Yes Yes 7 9 1 2
R:R:K110 R:R:S129 13.77 2 Yes Yes 8 7 2 1
R:R:H121 R:R:W128 7.41 0 No Yes 4 5 2 1
R:R:N130 R:R:W128 11.3 2 Yes Yes 8 5 2 1
H:H:?1 R:R:W128 6.1 2 No Yes 0 5 2 1
H:H:?1 R:R:N130 24.5 2 No Yes 0 8 2 2
L:L:T31 R:R:W79 2.43 0 Yes Yes 0 6 2 2
L:L:T31 R:R:W128 2.43 0 Yes Yes 0 5 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.56
Average Nodes In Shell13.00
Average Hubs In Shell10.00
Average Links In Shell19.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TZF B1 Peptide Calcitonin CT (AMY3) Homo sapiens Amylin - Gs/Beta1/Gamma2; RAMP3 2.4 2022-03-23 10.1126/science.abm9609

A 2D representation of the interactions of NH2 in 7TZF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N31 L:L:T36 5.85 0 No No 0 0 2 1
L:L:?38 L:L:T36 7.35 0 No No 0 0 0 1
L:L:?38 R:R:W128 11.35 0 No Yes 0 5 0 1
L:L:?38 R:R:Y131 5.84 0 No Yes 0 5 0 1
R:R:D77 R:R:S129 5.89 1 No Yes 9 7 2 2
R:R:D77 R:R:Y131 8.05 1 No Yes 9 5 2 1
R:R:W79 R:R:Y131 12.54 1 Yes Yes 6 5 2 1
R:R:L80 R:R:P96 8.21 1 Yes Yes 5 9 2 2
R:R:L80 R:R:V108 4.47 1 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 8.21 1 Yes Yes 5 5 2 1
R:R:P96 R:R:Y131 4.17 1 Yes Yes 9 5 2 1
R:R:V108 R:R:Y131 13.88 1 Yes Yes 7 5 2 1
R:R:F119 R:R:W128 4.01 0 No Yes 4 5 2 1
R:R:H121 R:R:W128 17.98 7 Yes Yes 4 5 2 1
R:R:N130 R:R:W128 12.43 7 Yes Yes 8 5 2 1
H:H:?2 R:R:W128 7.11 7 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 10.17 1 Yes Yes 7 5 2 1
H:H:?2 R:R:N130 22.05 7 Yes Yes 0 8 2 2
R:R:C134 R:R:Y131 4.03 0 No Yes 9 5 2 1
L:L:G33 L:L:T36 1.82 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.18
Average Nodes In Shell17.00
Average Hubs In Shell10.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7W3Z A Peptide Bombesin BB2 Homo Sapiens Gastrin Releasing Peptide - chim(NtGi1L-Gq)/Beta1/Gamma2 3 2023-02-22 10.1073/pnas.2216230120

A 2D representation of the interactions of NH2 in 7W3Z
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D97 R:R:Y47 6.9 1 Yes Yes 6 7 1 2
R:R:F312 R:R:Y47 4.13 1 Yes Yes 7 7 2 2
R:R:C93 R:R:L89 4.76 1 Yes Yes 7 7 2 2
L:L:M27 R:R:L89 7.07 1 Yes Yes 0 7 1 2
R:R:C93 R:R:F312 4.19 1 Yes Yes 7 7 2 2
L:L:M27 R:R:C93 4.86 1 Yes Yes 0 7 1 2
R:R:R100 R:R:V96 3.92 0 Yes Yes 5 6 1 2
R:R:D97 R:R:Y101 8.05 1 Yes Yes 6 4 1 2
R:R:D97 R:R:R308 4.76 1 Yes Yes 6 5 1 1
L:L:?28 R:R:D97 6.76 1 Yes Yes 0 6 0 1
R:R:R100 R:R:W106 9 0 Yes Yes 5 8 1 2
L:L:H25 R:R:R100 7.9 1 Yes Yes 0 5 2 1
L:L:?28 R:R:R100 3.03 1 Yes Yes 0 5 0 1
L:L:M27 R:R:W277 5.82 1 Yes Yes 0 8 1 2
R:R:N280 R:R:R308 9.64 0 No Yes 5 5 2 1
L:L:M27 R:R:N280 7.01 1 Yes No 0 5 1 2
R:R:I283 R:R:R287 6.26 1 No Yes 5 4 2 2
R:R:I283 R:R:R308 5.01 1 No Yes 5 5 2 1
R:R:R287 R:R:R308 7.46 1 Yes Yes 4 5 2 1
L:L:?28 R:R:R308 15.14 1 Yes Yes 0 5 0 1
L:L:M27 R:R:F312 4.98 1 Yes Yes 0 7 1 2
L:L:L26 L:L:M27 7.07 0 No Yes 0 0 2 1
L:L:?28 L:L:M27 7.05 1 Yes Yes 0 0 0 1
L:L:G24 R:R:R100 1.5 0 No Yes 0 5 2 1
L:L:G24 R:R:R287 1.5 0 No Yes 0 4 2 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.00
Average Nodes In Shell19.00
Average Hubs In Shell15.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7X1T A Peptide Thyrotropin-releasing hormone TRH Homo sapiens Taltirelin - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.26 2022-08-31 10.1038/s41422-022-00646-6

A 2D representation of the interactions of NH2 in 7X1T
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V32 R:R:Y310 3.79 1 Yes Yes 7 7 2 1
R:R:L75 R:R:Y310 3.52 0 Yes Yes 7 7 2 1
R:R:G79 R:R:Y310 5.79 0 No Yes 7 7 2 1
R:R:N82 R:R:R306 3.62 1 No No 6 5 1 1
R:R:N82 R:R:Y310 8.14 1 No Yes 6 7 1 1
L:L:?5 R:R:N82 3.42 1 Yes No 0 6 0 1
L:L:P4 R:R:Q105 9.47 0 Yes Yes 0 7 1 2
L:L:H3 R:R:Y106 5.44 1 Yes Yes 0 5 2 2
L:L:P4 R:R:Y106 4.17 0 Yes Yes 0 5 1 2
L:L:P4 R:R:I109 3.39 0 Yes Yes 0 7 1 2
L:L:P4 R:R:Y282 4.17 0 Yes No 0 5 1 2
L:L:H3 R:R:R306 3.39 1 Yes No 0 5 2 1
L:L:?5 R:R:R306 15.14 1 Yes No 0 5 0 1
L:L:?5 R:R:Y310 8.76 1 Yes Yes 0 7 0 1
L:L:?5 L:L:P4 8.18 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.88
Average Nodes In Shell13.00
Average Hubs In Shell9.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell14.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7X1U A Peptide Thyrotropin-releasing hormone TRH Homo sapiens TRH - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.19 2022-08-31 10.1038/s41422-022-00646-6

A 2D representation of the interactions of NH2 in 7X1U
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V32 R:R:Y310 7.57 0 No Yes 7 7 2 1
R:R:I35 R:R:Y310 2.42 0 Yes Yes 7 7 2 1
R:R:A78 R:R:Q105 4.55 4 No No 7 7 2 2
L:L:P3 R:R:A78 3.74 4 Yes No 0 7 1 2
R:R:N82 R:R:R306 12.05 4 No Yes 6 5 1 1
R:R:N82 R:R:Y310 6.98 4 No Yes 6 7 1 1
L:L:?4 R:R:N82 10.27 4 Yes No 0 6 0 1
L:L:P3 R:R:Q105 11.05 4 Yes No 0 7 1 2
L:L:P3 R:R:Y282 4.17 4 Yes Yes 0 5 1 2
R:R:L302 R:R:R306 4.86 4 Yes Yes 4 5 2 1
L:L:?1 R:R:L302 7.37 4 Yes Yes 0 4 2 2
R:R:R306 R:R:Y310 8.23 4 Yes Yes 5 7 1 1
L:L:?1 R:R:R306 6.47 4 Yes Yes 0 5 2 1
L:L:P3 R:R:R306 4.32 4 Yes Yes 0 5 1 1
L:L:?4 R:R:R306 18.16 4 Yes Yes 0 5 0 1
L:L:P3 R:R:Y310 2.78 4 Yes Yes 0 7 1 1
L:L:?4 R:R:Y310 2.92 4 Yes Yes 0 7 0 1
L:L:?4 L:L:P3 4.09 4 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.86
Average Nodes In Shell12.00
Average Hubs In Shell8.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XK8 A Peptide Neuromedin U NMUR2 Homo sapiens Neuromedin-U-25 - Gi1/Beta1/Gamma2 3.3 2023-02-22 10.1038/s41467-022-34814-4

A 2D representation of the interactions of NH2 in 7XK8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N25 L:L:P23 8.15 0 Yes No 0 0 1 2
L:L:R24 R:R:F126 4.28 10 Yes Yes 0 6 2 1
L:L:R24 R:R:F284 4.28 10 Yes No 0 6 2 2
L:L:?26 L:L:N25 6.84 11 Yes Yes 0 0 0 1
L:L:N25 R:R:H185 5.1 0 Yes No 0 5 1 2
L:L:N25 R:R:Y213 5.81 0 Yes Yes 0 2 1 2
L:L:?26 R:R:T123 3.67 11 Yes No 0 5 0 1
L:L:?26 R:R:F126 3.03 11 Yes Yes 0 6 0 1
L:L:?26 R:R:E127 13.21 11 Yes Yes 0 4 0 1
L:L:?26 R:R:N181 3.42 11 Yes Yes 0 4 0 1
L:L:?26 R:R:R288 3.03 11 Yes Yes 0 5 0 1
R:R:F126 R:R:V94 3.93 0 Yes No 6 7 1 2
R:R:T123 R:R:T182 4.71 0 No No 5 5 1 2
R:R:E127 R:R:F131 24.49 11 Yes No 4 6 1 2
R:R:E127 R:R:S178 5.75 11 Yes No 4 7 1 2
R:R:E127 R:R:N181 3.94 11 Yes Yes 4 4 1 1
R:R:E127 R:R:R288 3.49 11 Yes Yes 4 5 1 1
R:R:I216 R:R:N181 2.83 0 No Yes 5 4 2 1
R:R:I217 R:R:N181 4.25 0 No Yes 5 4 2 1
R:R:I217 R:R:Y213 14.51 0 No Yes 5 2 2 2
R:R:I217 R:R:R288 11.27 0 No Yes 5 5 2 1
R:R:R288 R:R:S221 3.95 11 Yes No 5 5 1 2
R:R:F284 R:R:R288 6.41 0 No Yes 6 5 2 1
R:R:F126 R:R:L97 2.44 0 Yes No 6 5 1 2
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub5.00
Average Interaction Strength5.53
Average Nodes In Shell20.00
Average Hubs In Shell8.00
Average Links In Shell24.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XNA A Peptide Somatostatin SST2 Homo sapiens CYN154806 - - 2.65 2022-08-03 10.1038/s41422-022-00679-x

A 2D representation of the interactions of NH2 in 7XNA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:N43 R:R:V103 4.43 1 Yes Yes 3 4 1 2
R:R:E106 R:R:N43 10.52 1 No Yes 4 3 2 1
L:L:?9 R:R:N43 6.6 1 Yes Yes 0 3 1 1
L:L:?10 R:R:N43 10.27 1 No Yes 0 3 0 1
L:L:?9 R:R:V103 4.77 1 Yes Yes 0 4 1 2
L:L:?9 R:R:E106 10.61 1 Yes No 0 4 1 2
L:L:T7 R:R:D295 4.34 1 No Yes 0 2 2 2
L:L:?9 R:R:D295 6.52 1 Yes Yes 0 2 1 2
L:L:?9 L:L:Y4 16.89 1 Yes No 0 0 1 2
L:L:?9 L:L:T7 9.44 1 Yes No 0 0 1 2
L:L:?10 L:L:?9 13.81 1 No Yes 0 0 0 1
L:L:?10 R:R:S42 3.74 1 No No 0 4 0 1
R:R:N43 R:R:T41 2.92 1 Yes No 3 4 1 2
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.27
Average Nodes In Shell10.00
Average Hubs In Shell4.00
Average Links In Shell13.00
Average Links Mediated by Hubs In Shell12.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XOU A Peptide Cholecystokinin CCKA Homo sapiens Cholecystokinin-8 - Gs/Beta1/Gamma2 3.2 2022-07-20 10.1038/s41421-022-00420-3

A 2D representation of the interactions of NH2 in 7XOU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?9 L:L:F8 9.1 15 Yes Yes 0 0 0 1
L:L:F8 R:R:G122 3.01 0 Yes No 0 6 1 2
L:L:F8 R:R:V125 7.87 0 Yes No 0 7 1 2
L:L:F8 R:R:I329 5.02 0 Yes No 0 7 1 2
L:L:?9 R:R:C94 7.91 15 Yes Yes 0 7 0 1
L:L:?9 R:R:L356 3.45 15 Yes No 0 6 0 1
L:L:?9 R:R:Y360 8.76 15 Yes Yes 0 7 0 1
R:R:C94 R:R:L90 4.76 15 Yes No 7 8 1 2
R:R:C94 R:R:M121 4.86 15 Yes No 7 7 1 2
R:R:C94 R:R:Y360 8.06 15 Yes Yes 7 7 1 1
R:R:M95 R:R:Y360 4.79 0 Yes Yes 7 7 2 1
R:R:L356 R:R:N98 5.49 15 No No 6 7 1 2
R:R:N98 R:R:Y360 3.49 15 No Yes 7 7 2 1
R:R:L356 R:R:Y360 8.21 15 No Yes 6 7 1 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.30
Average Nodes In Shell12.00
Average Hubs In Shell5.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XW9 A Peptide Thyrotropin-releasing hormone TRH Homo sapiens TRH - chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2 2.7 2022-12-28 10.1038/s41421-022-00477-0

A 2D representation of the interactions of NH2 in 7XW9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:A78 R:R:Q105 4.55 1 No Yes 7 7 1 1
L:L:?4 R:R:A78 3.93 1 Yes No 0 7 0 1
R:R:G79 R:R:N82 3.39 1 No No 7 6 2 2
R:R:G79 R:R:Y310 5.79 1 No Yes 7 7 2 1
R:R:N82 R:R:R306 3.62 1 No No 6 5 2 2
R:R:N82 R:R:Y310 8.14 1 No Yes 6 7 2 1
R:R:I101 R:R:Q105 4.12 0 No Yes 5 7 2 1
R:R:Q105 R:R:T102 5.67 1 Yes Yes 7 4 1 2
L:L:H2 R:R:T102 5.48 1 Yes Yes 0 4 2 2
L:L:H2 R:R:Q105 3.71 1 Yes Yes 0 7 2 1
L:L:P3 R:R:Q105 12.63 1 Yes Yes 0 7 1 1
L:L:?4 R:R:Q105 9.95 1 Yes Yes 0 7 0 1
R:R:I109 R:R:Y106 3.63 1 Yes Yes 7 5 2 2
R:R:Y106 R:R:Y282 2.98 1 Yes Yes 5 5 2 2
L:L:?1 R:R:Y106 3.74 1 Yes Yes 0 5 2 2
L:L:H2 R:R:Y106 10.89 1 Yes Yes 0 5 2 2
L:L:P3 R:R:Y106 11.13 1 Yes Yes 0 5 1 2
L:L:P3 R:R:I109 3.39 1 Yes Yes 0 7 1 2
R:R:I309 R:R:Y282 7.25 0 No Yes 6 5 2 2
L:L:?1 R:R:Y282 6.24 1 Yes Yes 0 5 2 2
L:L:P3 R:R:Y282 11.13 1 Yes Yes 0 5 1 2
R:R:R306 R:R:Y310 6.17 1 No Yes 5 7 2 1
R:R:I309 R:R:Y310 4.84 0 No Yes 6 7 2 1
L:L:?4 R:R:Y310 8.76 1 Yes Yes 0 7 0 1
L:L:?1 L:L:H2 9.58 1 Yes Yes 0 0 2 2
L:L:?1 L:L:P3 3.5 1 Yes Yes 0 0 2 1
L:L:H2 L:L:P3 4.58 1 Yes Yes 0 0 2 1
L:L:?4 L:L:P3 12.28 1 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.73
Average Nodes In Shell16.00
Average Hubs In Shell10.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y35 B1 Peptide Parathyroid hormone PTH1 Homo sapiens Abaloparatide - Gs/Beta1/Gamma2 2.9 2023-07-05  To be published

A 2D representation of the interactions of NH2 in 7Y35
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?29 L:L:K30 4.05 4 Yes No 0 0 1 2
L:L:?29 L:L:T33 8.47 4 Yes No 0 0 1 1
L:L:?29 L:L:?34 9.91 4 Yes No 0 0 1 0
L:L:H32 L:L:T33 2.74 4 Yes No 0 0 2 1
L:L:?34 L:L:T33 11.02 4 No No 0 0 0 1
L:L:?29 L:L:E25 1.27 4 Yes No 0 0 1 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub1.00
Average Interaction Strength10.46
Average Nodes In Shell6.00
Average Hubs In Shell2.00
Average Links In Shell6.00
Average Links Mediated by Hubs In Shell5.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F0J B1 Peptide Calcitonin CT Homo Sapiens Pramlintide analogue san45 - Gs/Beta1/Gamma2 2 2023-08-02 10.1038/s41589-023-01393-4

A 2D representation of the interactions of NH2 in 8F0J
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N31 L:L:T36 8.77 0 No No 0 0 2 1
L:L:?38 L:L:T36 7.35 0 Yes No 0 0 0 1
L:L:?38 L:L:Y37 2.92 0 Yes No 0 0 0 1
L:L:Y37 R:R:G78 10.14 0 No No 0 5 1 2
L:L:Y37 R:R:W79 12.54 0 No Yes 0 6 1 2
L:L:?38 R:R:W128 8.51 0 Yes Yes 0 5 0 1
L:L:?38 R:R:Y131 5.84 0 Yes Yes 0 5 0 1
R:R:D77 R:R:L80 4.07 6 Yes Yes 9 5 2 2
R:R:D77 R:R:S129 7.36 6 Yes Yes 9 7 2 2
R:R:D77 R:R:Y131 5.75 6 Yes Yes 9 5 2 1
R:R:F102 R:R:W79 6.01 6 Yes Yes 4 6 2 2
R:R:W79 R:R:Y131 18.33 6 Yes Yes 6 5 2 1
R:R:L80 R:R:P96 8.21 6 Yes Yes 5 9 2 2
R:R:L80 R:R:V108 4.47 6 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 8.21 6 Yes Yes 5 5 2 1
R:R:F102 R:R:P96 2.89 6 Yes Yes 4 9 2 2
R:R:P96 R:R:Y131 4.17 6 Yes Yes 9 5 2 1
R:R:F102 R:R:Y131 3.09 6 Yes Yes 4 5 2 1
R:R:C134 R:R:F102 8.38 6 No Yes 9 4 2 2
R:R:V108 R:R:Y131 15.14 6 Yes Yes 7 5 2 1
R:R:F119 R:R:W128 3.01 0 No Yes 4 5 2 1
R:R:H121 R:R:W128 23.27 8 Yes Yes 4 5 2 1
R:R:N130 R:R:W128 9.04 8 Yes Yes 8 5 2 1
H:H:?2 R:R:W128 10.16 8 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 6.36 6 Yes Yes 7 5 2 1
H:H:?2 R:R:N130 25.72 8 Yes Yes 0 8 2 2
R:R:C134 R:R:Y131 4.03 6 No Yes 9 5 2 1
L:L:G33 L:L:T36 1.82 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub2.00
Average Interaction Strength6.16
Average Nodes In Shell20.00
Average Hubs In Shell13.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell25.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F0K B1 Peptide Calcitonin CT (AMY3) Homo Sapiens Pramlintide analogue san385 - Gs/Beta1/Gamma2; RAMP3 1.9 2023-08-02 10.1038/s41589-023-01393-4

A 2D representation of the interactions of NH2 in 8F0K
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:E74 E:E:W84 9.81 2 No Yes 5 9 2 2
E:E:E74 L:L:Y37 4.49 2 No Yes 5 0 2 1
E:E:W84 L:L:Y37 4.82 2 Yes Yes 9 0 2 1
L:L:?38 L:L:Y37 5.84 2 Yes Yes 0 0 0 1
L:L:Y37 R:R:G78 4.35 2 Yes No 0 5 1 2
L:L:Y37 R:R:W79 11.58 2 Yes Yes 0 6 1 2
L:L:Y37 R:R:R126 4.12 2 Yes No 0 4 1 2
L:L:?38 R:R:D77 10.15 2 Yes Yes 0 9 0 1
L:L:?38 R:R:S129 7.48 2 Yes Yes 0 7 0 1
L:L:?38 R:R:Y131 5.84 2 Yes Yes 0 5 0 1
R:R:D77 R:R:W82 7.82 2 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 7.36 2 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 6.9 2 Yes Yes 9 5 1 1
R:R:W79 R:R:Y131 17.36 2 Yes Yes 6 5 2 1
R:R:L80 R:R:V108 4.47 2 Yes No 5 7 2 2
R:R:L80 R:R:Y131 8.21 2 Yes Yes 5 5 2 1
R:R:K110 R:R:W82 23.21 2 Yes Yes 8 9 2 2
R:R:S129 R:R:W82 3.71 2 Yes Yes 7 9 1 2
R:R:V108 R:R:Y131 13.88 2 No Yes 7 5 2 1
R:R:K110 R:R:S129 10.71 2 Yes Yes 8 7 2 1
R:R:S129 R:R:Y131 5.09 2 Yes Yes 7 5 1 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.33
Average Nodes In Shell14.00
Average Hubs In Shell10.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F2A B1 Peptide Calcitonin CT (AMY3) Homo Sapiens Pramlintide analogue san385 - Gs/Beta1/Gamma2; RAMP3 2.2 2023-08-02 10.1038/s41589-023-01393-4

A 2D representation of the interactions of NH2 in 8F2A
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:N31 L:L:T36 4.39 0 No No 0 0 2 1
L:L:?38 L:L:T36 7.35 0 No No 0 0 0 1
L:L:?38 R:R:W128 11.35 0 No Yes 0 5 0 1
L:L:?38 R:R:Y131 5.84 0 No Yes 0 5 0 1
R:R:D77 R:R:S129 7.36 2 No Yes 9 7 2 2
R:R:D77 R:R:Y131 11.49 2 No Yes 9 5 2 1
R:R:W79 R:R:Y131 17.36 2 Yes Yes 6 5 2 1
R:R:L80 R:R:P96 9.85 2 Yes Yes 5 9 2 2
R:R:L80 R:R:V108 4.47 2 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 8.21 2 Yes Yes 5 5 2 1
R:R:P96 R:R:Y131 4.17 2 Yes Yes 9 5 2 1
R:R:V108 R:R:Y131 13.88 2 Yes Yes 7 5 2 1
R:R:H121 R:R:W128 25.39 0 No Yes 4 5 2 1
R:R:N130 R:R:W128 11.3 12 Yes Yes 8 5 2 1
H:H:?2 R:R:W128 7.11 12 No Yes 0 5 2 1
R:R:S129 R:R:Y131 5.09 2 Yes Yes 7 5 2 1
H:H:?2 R:R:N130 29.4 12 No Yes 0 8 2 2
L:L:G33 L:L:T36 1.82 0 No No 0 0 2 1
StatisticsValue
Average Number Of Links3.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.18
Average Nodes In Shell15.00
Average Hubs In Shell8.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F2B B1 Peptide Calcitonin CT (AMY3) Homo Sapiens Pramlintide analogue san45 - Gs/Beta1/Gamma2; RAMP3 2 2023-08-02 10.1038/s41589-023-01393-4

A 2D representation of the interactions of NH2 in 8F2B
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:E74 E:E:W84 18.54 1 No Yes 5 9 2 2
E:E:E74 L:L:Y37 4.49 1 No Yes 5 0 2 1
E:E:W84 L:L:Y37 5.79 1 Yes Yes 9 0 2 1
L:L:?38 L:L:Y37 5.84 1 Yes Yes 0 0 0 1
L:L:Y37 R:R:G78 11.59 1 Yes No 0 5 1 2
L:L:Y37 R:R:W79 13.5 1 Yes Yes 0 6 1 2
L:L:?38 R:R:D77 3.38 1 Yes Yes 0 9 0 1
L:L:?38 R:R:W128 5.68 1 Yes Yes 0 5 0 1
L:L:?38 R:R:S129 7.48 1 Yes Yes 0 7 0 1
R:R:D77 R:R:G78 3.35 1 Yes No 9 5 1 2
R:R:D77 R:R:L80 4.07 1 Yes Yes 9 5 1 2
R:R:D77 R:R:W82 10.05 1 Yes Yes 9 9 1 2
R:R:D77 R:R:S129 5.89 1 Yes Yes 9 7 1 1
R:R:D77 R:R:Y131 8.05 1 Yes Yes 9 5 1 2
R:R:W79 R:R:Y131 14.47 1 Yes Yes 6 5 2 2
R:R:L80 R:R:Y131 9.38 1 Yes Yes 5 5 2 2
R:R:K110 R:R:W82 19.73 1 Yes Yes 8 9 2 2
R:R:K110 R:R:S129 6.12 1 Yes Yes 8 7 2 1
R:R:H121 R:R:W128 23.27 1 Yes Yes 4 5 2 1
R:R:N130 R:R:W128 11.3 1 Yes Yes 8 5 2 1
H:H:?3 R:R:W128 5.08 1 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 7.63 1 Yes Yes 7 5 1 2
H:H:?3 R:R:N130 26.95 1 Yes Yes 0 8 2 2
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.59
Average Nodes In Shell16.00
Average Hubs In Shell14.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F7R A Peptide Opioid MOP Homo sapiens Endomorphin - Gi1/Beta1/Gamma2 3.28 2022-12-14 10.1016/j.cell.2022.12.026

A 2D representation of the interactions of NH2 in 8F7R
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:H321 R:R:Y77 10.89 1 Yes Yes 4 7 2 2
R:R:I324 R:R:Y77 8.46 1 Yes Yes 5 7 2 2
L:L:F4 R:R:Y77 4.13 1 Yes Yes 0 7 1 2
L:L:W3 R:R:Q126 5.48 1 Yes Yes 0 6 2 2
L:L:F4 R:R:Q126 14.05 1 Yes Yes 0 6 1 2
R:R:N129 R:R:W135 7.91 1 No Yes 4 8 1 2
L:L:W3 R:R:N129 3.39 1 Yes No 0 4 2 1
L:L:?5 R:R:N129 13.69 0 No No 0 4 0 1
R:R:H321 R:R:Y130 11.98 1 Yes No 4 5 2 2
L:L:F4 R:R:Y130 6.19 1 Yes No 0 5 1 2
L:L:W3 R:R:W135 4.69 1 Yes Yes 0 8 2 2
L:L:F4 R:R:H321 6.79 1 Yes Yes 0 4 1 2
L:L:F4 R:R:I324 3.77 1 Yes Yes 0 5 1 2
L:L:?5 L:L:F4 9.1 0 No Yes 0 0 0 1
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub1.00
Average Interaction Strength11.39
Average Nodes In Shell10.00
Average Hubs In Shell7.00
Average Links In Shell14.00
Average Links Mediated by Hubs In Shell13.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F7S A Peptide Opioid DOP Homo sapiens Deltorphin - Gi1/Beta1/Gamma2 3 2022-12-14 10.1016/j.cell.2022.12.026

A 2D representation of the interactions of NH2 in 8F7S
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:F3 R:R:Q105 10.54 5 Yes Yes 0 5 1 2
R:R:K108 R:R:W114 4.64 5 No Yes 4 8 1 2
L:L:G7 R:R:K108 3.49 5 No No 0 4 1 1
L:L:?8 R:R:K108 10.54 5 Yes No 0 4 0 1
R:R:C198 R:R:W114 6.53 5 Yes Yes 9 8 2 2
L:L:F3 R:R:W114 5.01 5 Yes Yes 0 8 1 2
L:L:F3 R:R:V124 2.62 5 Yes No 0 5 1 2
R:R:C198 R:R:L125 3.17 5 Yes No 9 5 2 2
L:L:F3 R:R:L125 4.87 5 Yes No 0 5 1 2
L:L:G7 R:R:V197 3.68 5 No No 0 4 1 2
L:L:F3 R:R:C198 5.59 5 Yes Yes 0 9 1 2
L:L:V6 R:R:L300 2.98 0 Yes Yes 0 5 1 2
L:L:V6 R:R:H301 2.77 0 Yes Yes 0 4 1 2
L:L:?2 L:L:F3 2.48 0 Yes Yes 0 0 2 1
L:L:?2 L:L:V6 4.55 0 Yes Yes 0 0 2 1
L:L:?8 L:L:F3 18.21 5 Yes Yes 0 0 0 1
L:L:?8 L:L:V6 7.42 5 Yes Yes 0 0 0 1
L:L:?8 L:L:G7 4.26 5 Yes No 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub2.00
Average Interaction Strength10.11
Average Nodes In Shell14.00
Average Hubs In Shell9.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IA7 A Peptide Cholecystokinin CCKB Homo sapiens Cholecystokinin-8 - chim(NtGi1L-Gq)/Beta1/Gamma2 3.1 2023-12-06 10.1038/s41421-022-00420-3

A 2D representation of the interactions of NH2 in 8IA7
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C107 R:R:M134 6.48 0 No Yes 7 8 2 1
R:R:C107 R:R:Y380 8.06 0 No Yes 7 7 2 1
R:R:M108 R:R:Y380 3.59 0 No Yes 7 7 2 1
R:R:T111 R:R:Y380 3.75 0 No Yes 7 7 2 1
R:R:M134 R:R:V130 4.56 0 Yes No 8 6 1 2
L:L:M6 R:R:M134 2.89 0 Yes Yes 0 8 2 1
L:L:?9 R:R:M134 14.09 10 Yes Yes 0 8 0 1
L:L:F8 R:R:V138 6.55 0 Yes No 0 7 1 2
L:L:F8 R:R:Y189 4.13 0 Yes Yes 0 7 1 2
R:R:S379 R:R:V349 3.23 0 No No 7 7 2 2
L:L:F8 R:R:V349 3.93 0 Yes No 0 7 1 2
R:R:H376 R:R:I372 5.3 10 No Yes 5 4 1 2
R:R:H376 R:R:Y380 6.53 10 No Yes 5 7 1 1
L:L:?9 R:R:H376 3.2 10 Yes No 0 5 0 1
R:R:S379 R:R:Y380 3.82 0 No Yes 7 7 2 1
L:L:?9 R:R:Y380 2.92 10 Yes Yes 0 7 0 1
L:L:?9 L:L:F8 9.1 10 Yes Yes 0 0 0 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.33
Average Nodes In Shell15.00
Average Hubs In Shell7.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IOD A Peptide Melanocortin MC5 Homo Sapiens PG-901 Ca chim(NtGi1-Gs)/Beta1/Gamma2 2.59 2023-09-20 10.1038/s41421-023-00586-4

A 2D representation of the interactions of NH2 in 8IOD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:D2 L:L:P3 12.88 24 No No 0 0 2 2
L:L:D2 L:L:K7 20.74 24 No Yes 0 0 2 1
L:L:K7 L:L:P3 5.02 24 Yes No 0 0 1 2
L:L:?8 L:L:K7 10.54 0 No Yes 0 0 0 1
L:L:K7 R:R:F277 17.37 24 Yes Yes 0 4 1 2
L:L:?8 R:R:H257 6.41 0 No Yes 0 4 0 1
R:R:H257 R:R:M274 7.88 0 Yes No 4 1 1 2
R:R:F277 R:R:H257 9.05 0 Yes Yes 4 4 2 1
R:R:H257 R:R:Y280 4.36 0 Yes Yes 4 5 1 2
StatisticsValue
Average Number Of Links2.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.47
Average Nodes In Shell8.00
Average Hubs In Shell4.00
Average Links In Shell9.00
Average Links Mediated by Hubs In Shell8.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links4.08
Average Number Of Links With An Hub3.08
Average Interaction Strength7.77
Average Nodes In Shell14.58
Average Hubs In Shell9.45
Average Links In Shell21.05
Average Links Mediated by Hubs In Shell20.00

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)