Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1E:E:M33 4.47408
2E:E:C40 3.8025419
3E:E:F44 9.015619
4E:E:M48 6.77167619
5E:E:K55 11.4525414
6E:E:W56 4.8525417
7E:E:L59 7.5417
8E:E:E61 7.85416
9E:E:F69 7.792518
10E:E:E76 4.9325416
11E:E:W84 10.1967619
12E:E:F92 4.025418
13E:E:H97 7.148519
14E:E:F100 8.888518
15E:E:F101 8.404519
16E:E:P114 8.885409
17L:L:C2 5.785450
18L:L:T4 3.805450
19L:L:T6 6.274550
20L:L:C7 6.29450
21L:L:Q10 4.555450
22L:L:F15 9.535400
23L:L:L16 4.4525400
24L:L:Y37 7.3125410
25R:R:Q52 8.03616
26R:R:Y53 8.228511
27R:R:Y56 8.00667613
28R:R:L62 7.185413
29R:R:R74 10.4625414
30R:R:W76 9.27667618
31R:R:W79 9.542516
32R:R:L80 7.486515
33R:R:W82 11.0229719
34R:R:T85 4.654517
35R:R:P96 8.0025419
36R:R:Y98 7.38167614
37R:R:F99 9.05333615
38R:R:D101 6.6125414
39R:R:F102 7.62614
40R:R:D103 5.6775403
41R:R:V108 6.6675417
42R:R:C112 4.5575419
43R:R:W118 9.1519
44R:R:H121 10.2675474
45R:R:W128 10.576575
46R:R:S129 7.78417
47R:R:N130 13.0175478
48R:R:Y131 8.36815
49R:R:N135 4.704513
50R:R:F137 5.5454221
51R:R:L148 6.814165
52R:R:Y149 7.378505
53R:R:H156 8.8075407
54R:R:F170 6.6575408
55R:R:F173 5.25407
56R:R:L176 6.2409
57R:R:Q179 5.9975447
58R:R:R180 7.0325409
59R:R:V181 5.1575409
60R:R:Y191 9.11714758
61R:R:N233 9.0175459
62R:R:Y234 7.95657
63R:R:F235 5.8154205
64R:R:W236 8.76714759
65R:R:M237 5.7875459
66R:R:I242 4.992547
67R:R:Y243 7.836548
68R:R:L244 5.23409
69R:R:F253 7.92167646
70R:R:Q257 6.842545
71R:R:L259 6.85405
72R:R:W261 5.312502
73R:R:Y262 5.87167647
74R:R:W267 8.39559
75R:R:F269 5.3185203
76R:R:P270 3.9375409
77R:R:H277 10.01487
78R:R:R281 10.026587
79R:R:F285 10.382586
80R:R:W290 11.23589
81R:R:L291 3.7725406
82R:R:T295 8.78484
83R:R:Y299 4.6775457
84R:R:H302 5.96167656
85R:R:F313 5.235406
86R:R:K326 8.59449
87R:R:M327 5.658547
88R:R:L348 4.685409
89R:R:Q355 8.92458
90R:R:F356 7.64333657
91R:R:R362 8.34404
92R:R:Y374 6.29254166
93R:R:M376 5.435407
94R:R:H377 8.3054167
95R:R:H381 7.954509
96R:R:Q383 9.7525459
97R:R:F385 9.1325405
98R:R:Y391 7.7265248
99R:R:C392 6.09254239
100R:R:F393 4.9654238
101R:R:N396 3.3975406
102R:R:T401 5.41254107
103R:R:Q405 5.5854104
104A:A:R13 5.245434
105A:A:Y37 8.012534
106A:A:K53 5.58254269
107A:A:F219 5.44667648
108A:A:F222 11.12527
109A:A:K233 6.315629
110A:A:W234 7.835409
111A:A:F238 10.405429
112A:A:V247 4.5625127
113A:A:Y253 8.97408
114A:A:F273 5.953336279
115A:A:W277 12.48754276
116A:A:W281 13.1183625
117A:A:I288 4.9725409
118A:A:L289 4.945409
119A:A:F290 5.72509
120A:A:N292 5.2365129
121A:A:K293 4.4775409
122A:A:Q294 6.9954116
123A:A:F312 7.20254188
124A:A:E314 5.94754186
125A:A:F315 13.0475406
126A:A:D331 5.60254284
127A:A:V334 5.36404
128A:A:Y339 8.1625113
129A:A:F340 12.2465187
130A:A:R342 7.4045114
131A:A:E344 7.6365185
132A:A:F345 8.02408
133A:A:P361 4.4354115
134A:A:F363 11.8945115
135A:A:T364 5.844129
136A:A:D368 5.24129
137A:A:R373 6.535445
138A:A:R374 8.2065124
139A:A:F376 6.8648
140A:A:R385 7.85545
141A:A:H387 8.8925448
142A:A:L394 4.6925448
143B:B:L4 4.625404
144B:B:I18 4.615407
145B:B:I37 5.3885132
146B:B:H54 9.686539
147B:B:K57 11.256529
148B:B:Y59 8.24528
149B:B:M61 3.9525436
150B:B:W63 6.365637
151B:B:D76 7.592539
152B:B:I81 6.05254147
153B:B:W82 11.395639
154B:B:N88 10.365437
155B:B:K89 5.60833639
156B:B:I93 6.09407
157B:B:L95 4.665408
158B:B:W99 8.60833629
159B:B:M101 6.1175429
160B:B:Y105 58146
161B:B:N110 6.194154
162B:B:Y111 6.8145154
163B:B:L117 4.8025429
164B:B:I123 3.895406
165B:B:Y124 5.87406
166B:B:N125 6.32254154
167B:B:L126 4.854145
168B:B:H142 8.562529
169B:B:Y145 6.81125828
170B:B:F151 5.812509
171B:B:I157 5.41407
172B:B:D163 10.475429
173B:B:C166 4.935498
174B:B:W169 8.41571728
175B:B:F180 8.678597
176B:B:H183 8.77699
177B:B:V187 5.578599
178B:B:F199 10.0875499
179B:B:S201 4.6075499
180B:B:C204 5.336527
181B:B:D205 7.0625499
182B:B:K209 10.016596
183B:B:L210 5.74195
184B:B:W211 10.11698
185B:B:F222 7.678568
186B:B:H225 8.92857769
187B:B:D228 9.194529
188B:B:I232 5.475468
189B:B:F234 5.0975405
190B:B:F235 9.7956176
191B:B:N237 9.74254175
192B:B:F241 8.42566
193B:B:T243 5.955468
194B:B:D246 7.55429
195B:B:D247 8.42569
196B:B:T249 8.2175466
197B:B:R251 12.0633668
198B:B:F253 6.56333666
199B:B:D254 5.4175409
200B:B:D258 9.93754297
201B:B:Q259 4.325406
202B:B:E260 8.5775466
203B:B:M262 7.335404
204B:B:Y264 8.532505
205B:B:H266 7.6775424
206B:B:I269 3.9725424
207B:B:I273 6.355426
208B:B:R283 8.5845139
209B:B:L284 5.475405
210B:B:L285 5.3875406
211B:B:Y289 8.15143727
212B:B:D290 7.52526
213B:B:N295 7.412526
214B:B:L300 6.56254136
215B:B:K301 8.3475405
216B:B:H311 10.6385109
217B:B:R314 15.428528
218B:B:W332 10.2686729
219B:B:D333 10.37754109
220B:B:L336 5.478537
221B:B:K337 9.1945106
222B:B:W339 12.5854109
223G:G:V16 2.535407
224G:G:L19 3.8425409
225G:G:R27 9.66754298
226G:G:L37 5.05754177
227G:G:Y40 11.76754176
228G:G:D48 6.86409
229G:G:L51 4.995406
230G:G:N59 7.806539
231G:G:P60 6.55439
232G:G:F61 5.55444938
233H:H:?2 10.1925470
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1E:E:C40 E:E:E76 14.32544.56YesYes196
2E:E:C40 E:E:T73 17.6313.38YesNo199
3E:E:F44 E:E:Y66 15.42534.13YesNo099
4E:E:H97 R:R:Y53 20.56298.71YesYes191
5E:E:H97 R:R:Y56 23.13475.44YesYes193
6E:E:I93 R:R:Y56 24.234514.51NoYes193
7E:E:I93 E:E:T73 18.72674.56NoNo199
8E:E:L59 R:R:Y53 11.75294.69YesYes171
9E:E:L59 E:E:R108 10.28634.86YesNo174
10R:R:Q52 R:R:Y56 17.6256.76YesYes163
11E:E:W84 R:R:Q52 41.48233.29YesYes196
12R:R:W76 R:R:Y56 35.24488.68YesYes183
13E:E:W84 R:R:W76 21.6594.69YesYes198
14E:E:W84 L:L:Y37 64.23836.75YesYes190
15R:R:G78 R:R:W76 21.65828.44NoYes058
16L:L:Y37 R:R:G78 22.02464.35YesNo005
17L:L:Y37 R:R:W79 87.362812.54YesYes106
18R:R:W79 R:R:Y131 93.185112.54YesYes165
19L:L:?38 R:R:Y131 1005.83NoYes005
20L:L:?38 R:R:W128 10011.33NoYes005
21H:H:?2 R:R:W128 1007.13YesYes705
22H:H:?2 R:R:M133 1007.59YesNo005
23R:R:F137 R:R:M133 1002.49YesNo015
24R:R:E106 R:R:F137 1009.33NoYes2241
25R:R:D103 R:R:E106 1007.8YesNo034
26R:R:D103 R:R:P104 1006.44YesNo033
27R:R:E294 R:R:P104 1004.72NoNo033
28L:L:K1 R:R:E294 1008.1NoNo003
29L:L:K1 L:L:R11 1003.71NoNo500
30L:L:C7 L:L:R11 1004.18YesNo500
31L:L:C7 R:R:H302 81.290110.32YesYes506
32L:L:C7 L:L:T4 54.063.38YesYes500
33L:L:T4 L:L:T6 58.3554.71YesYes500
34L:L:T6 R:R:Y234 58.49948.74YesYes507
35R:R:M237 R:R:Y234 87.87534.79YesYes597
36L:L:T6 R:R:H302 57.59548.21YesYes506
37R:R:H302 R:R:M230 28.94955.25YesNo566
38R:R:M230 R:R:Y234 29.16823.59NoYes567
39L:L:T6 R:R:F356 57.87555.19YesYes507
40R:R:M237 R:R:Y191 86.89285.99YesYes598
41R:R:L163 R:R:Y191 77.39323.52NoYes088
42R:R:F188 R:R:L163 77.45856.09NoNo088
43R:R:F170 R:R:F188 1004.29YesNo088
44R:R:F356 R:R:Q383 62.08114.68YesYes579
45R:R:Q383 R:R:Y191 62.432114.65YesYes598
46R:R:V387 R:R:Y191 77.36436.31NoYes098
47R:R:F188 R:R:V387 77.3863.93NoNo089
48R:R:F170 R:R:L176 1004.87YesYes089
49R:R:F173 R:R:L176 54.01313.65YesYes079
50R:R:F173 R:R:Q405 54.19347.03YesYes074
51R:R:L176 R:R:T401 10010.32YesYes097
52R:R:Q405 R:R:T401 53.98184.25YesYes1047
53B:B:D312 B:B:D333 1006.65NoYes1059
54B:B:D312 R:R:R404 53.966213.1NoNo1057
55R:R:R404 R:R:T401 53.98193.88NoYes1077
56B:B:D312 R:R:Q405 1005.22NoYes1054
57B:B:L336 B:B:M61 15.89594.24YesYes376
58B:B:C317 B:B:M61 36.80064.86NoYes076
59B:B:C317 B:B:S316 37.13463.44NoNo079
60B:B:S316 B:B:W332 37.30184.94NoYes099
61B:B:R314 B:B:W332 10021.99YesYes289
62B:B:R314 B:B:T274 1006.47YesNo088
63B:B:S275 B:B:T274 1004.8NoNo088
64B:B:L318 B:B:S275 1007.51NoNo068
65B:B:G319 B:B:L318 1003.42NoNo056
66B:B:G319 B:B:S277 1003.71NoNo055
67B:B:S277 B:B:V320 1004.85NoNo057
68B:B:V320 B:B:V327 1003.21NoNo076
69B:B:V327 G:G:L50 1004.47NoNo069
70B:B:M45 G:G:L50 1007.07NoNo049
71B:B:L308 B:B:M45 1004.24NoNo074
72B:B:L308 B:B:W339 10020.5NoYes079
73B:B:T329 B:B:W339 80.44329.7NoYes089
74B:B:H311 B:B:T329 80.51976.85YesNo098
75B:B:D333 B:B:H311 10012.61YesYes1099
76B:B:K337 B:B:W339 80.478110.44YesYes1069
77B:B:H311 B:B:K337 80.766717.03YesYes1096
78B:B:M61 B:B:W63 20.65073.49YesYes367
79B:B:D76 B:B:K78 21.41948.3YesNo098
80A:A:Y37 B:B:D76 11.0963.45YesYes349
81A:A:R42 A:A:Y37 13.096321.61NoYes094
82A:A:F222 A:A:R42 14.75873.21YesNo079
83A:A:F222 B:B:W99 16.092220.04YesYes279
84B:B:Q75 B:B:W99 19.00645.48NoYes299
85B:B:K57 B:B:W332 10.002915.08YesYes299
86B:B:W332 B:B:Y59 62.52736.75YesYes298
87B:B:D76 B:B:H54 11.10515.04YesYes399
88B:B:M101 B:B:Y145 50.87138.38YesYes298
89B:B:M101 B:B:Y59 51.36545.99YesYes298
90A:A:I235 A:A:W234 23.37123.52NoYes099
91A:A:I235 A:A:L282 23.69924.28NoNo099
92A:A:L282 A:A:N279 23.86359.61NoNo098
93A:A:N279 A:A:W281 24.02944.52NoYes085
94A:A:W281 B:B:R314 24.885824.99YesYes258
95A:A:W234 B:B:Y145 23.59195.79YesYes098
96A:A:R231 A:A:W234 46.287311NoYes099
97A:A:L272 A:A:R231 45.955210.93NoNo089
98A:A:F246 A:A:L272 45.29117.31NoNo098
99A:A:F246 A:A:F273 13.65466.43NoYes099
100A:A:F246 A:A:L289 31.30513.65NoYes099
101A:A:E344 A:A:L270 11.99553.98YesNo056
102A:A:F345 A:A:L270 15.990910.96YesNo086
103B:B:D290 B:B:R314 24.501816.68YesYes268
104A:A:L289 A:A:P361 12.65573.28YesYes095
105A:A:E330 A:A:T335 10.99819.88NoNo034
106A:A:T320 A:A:T335 12.99763.14NoNo014
107A:A:P321 A:A:T320 13.99413.5NoNo051
108A:A:P361 A:A:R342 11.99395.76YesYes1154
109A:A:A324 A:A:Y339 10.66029.34NoYes033
110B:B:Q259 B:B:R22 13.10297.01YesNo066
111B:B:Q259 G:G:V30 13.61875.73YesNo068
112B:B:L261 G:G:V30 13.79064.47NoNo058
113B:B:L261 B:B:L30 14.64125.54NoNo055
114B:B:L30 B:B:M262 15.84247.07NoYes054
115B:B:M262 B:B:Y264 16.700614.37YesYes045
116B:B:W297 B:B:Y264 20.13612.54NoYes085
117B:B:W297 B:B:Y289 20.2998.68NoYes287
118B:B:C271 B:B:Y289 23.04424.03NoYes257
119B:B:C271 B:B:D290 23.90323.11NoYes256
120B:B:I93 B:B:P94 18.0743.39YesNo075
121B:B:K78 B:B:P94 18.74295.02NoNo085
122B:B:I93 B:B:Y124 10.05626.04YesYes076
123B:B:C148 B:B:T102 10.76853.38NoNo068
124B:B:C149 B:B:T102 11.1073.38NoNo088
125B:B:H142 B:B:S161 22.032413.95YesNo299
126B:B:G162 B:B:S161 22.87533.71NoNo299
127B:B:G162 B:B:Y145 23.036810.14NoYes298
128B:B:I157 B:B:W169 14.65163.52YesYes078
129B:B:H142 B:B:W169 15.65244.23YesYes298
130B:B:L190 B:B:V158 10.09244.47NoNo055
131B:B:C148 B:B:L190 10.436.35NoNo065
132E:E:Y66 R:R:Q52 23.50243.38NoYes096
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:T70 E:E:W84 4.85 1 No Yes 9 9 2 1
E:E:T70 R:R:Q52 8.5 1 No Yes 9 6 2 2
E:E:E74 E:E:W84 29.44 1 No Yes 5 9 1 1
E:E:E74 L:L:Y37 5.61 1 No Yes 5 0 1 0
E:E:Y83 R:R:N124 6.98 7 No No 6 5 2 1
E:E:Y83 R:R:R126 23.66 7 No No 6 4 2 2
E:E:P85 E:E:W84 12.16 0 No Yes 9 9 2 1
E:E:W84 L:L:Y37 6.75 1 Yes Yes 9 0 1 0
E:E:W84 R:R:Q52 3.29 1 Yes Yes 9 6 1 2
E:E:W84 R:R:W76 4.69 1 Yes Yes 9 8 1 2
E:E:I123 R:R:Y299 3.63 0 No Yes 9 7 2 1
L:L:K1 R:R:V293 4.55 5 No No 0 6 0 1
L:L:K1 R:R:E294 8.1 5 No No 0 3 0 1
L:L:C2 R:R:Y299 8.06 5 Yes Yes 0 7 0 1
L:L:C2 R:R:H302 4.42 5 Yes Yes 0 6 0 1
L:L:N3 R:R:W361 21.47 0 No No 0 4 0 1
L:L:N3 R:R:R362 6.03 0 No Yes 0 4 0 1
L:L:T4 R:R:Y299 3.75 5 Yes Yes 0 7 0 1
L:L:T6 R:R:Y234 8.74 5 Yes Yes 0 7 0 1
L:L:T6 R:R:H302 8.21 5 Yes Yes 0 6 0 1
L:L:T6 R:R:M306 4.52 5 Yes No 0 4 0 1
L:L:T6 R:R:F356 5.19 5 Yes Yes 0 7 0 1
L:L:C7 R:R:H302 10.32 5 Yes Yes 0 6 0 1
L:L:A8 R:R:H377 4.39 0 No Yes 0 7 0 1
L:L:T9 R:R:H381 6.85 0 No Yes 0 9 0 1
L:L:Q10 R:R:H226 6.18 5 Yes No 0 6 0 1
L:L:Q10 R:R:M230 4.08 5 Yes No 0 6 0 1
L:L:Q10 R:R:H302 3.71 5 Yes Yes 0 6 0 1
L:L:R11 R:R:V293 3.92 5 No No 0 6 0 1
L:L:L12 R:R:L148 4.15 16 No Yes 0 5 0 1
L:L:L12 R:R:H377 5.14 16 No Yes 0 7 0 1
L:L:N14 R:R:V293 8.87 0 No No 0 6 0 1
L:L:F15 R:R:K141 18.61 0 Yes No 0 3 0 1
L:L:F15 R:R:L142 4.87 0 Yes No 0 2 0 1
L:L:L16 R:R:Y149 4.69 0 Yes Yes 0 5 0 1
L:L:L16 R:R:V206 4.47 0 Yes No 0 3 0 1
L:L:V17 R:R:V206 4.81 0 No No 0 3 0 1
L:L:V17 R:R:L291 4.47 0 No Yes 0 6 0 1
L:L:R18 R:R:P104 8.65 0 No No 0 3 0 1
L:L:S20 R:R:Y146 6.36 0 No No 0 2 0 1
L:L:N22 R:R:G209 5.09 0 No No 0 3 0 1
L:L:L23 R:R:Y146 7.03 0 No No 0 2 0 1
L:L:L23 R:R:Y149 8.21 0 No Yes 0 5 0 1
L:L:T30 R:R:F99 18.16 1 No Yes 0 5 0 1
L:L:T30 R:R:D101 8.67 1 No Yes 0 4 0 1
L:L:T30 R:R:F102 6.49 1 No Yes 0 4 0 1
L:L:V32 R:R:N135 7.39 0 No Yes 0 3 0 1
L:L:S34 R:R:H121 8.37 7 No Yes 0 4 0 1
L:L:S34 R:R:E123 4.31 7 No No 0 4 0 1
L:L:S34 R:R:N124 8.94 7 No No 0 5 0 1
L:L:Y37 R:R:G78 4.35 1 Yes No 0 5 0 1
L:L:Y37 R:R:W79 12.54 1 Yes Yes 0 6 0 1
L:L:?38 R:R:W128 11.33 0 No Yes 0 5 0 1
L:L:?38 R:R:Y131 5.83 0 No Yes 0 5 0 1
R:R:M48 R:R:W79 5.82 1 No Yes 6 6 2 1
R:R:M48 R:R:Y98 13.17 1 No Yes 6 4 2 2
R:R:Q52 R:R:W76 20.81 1 Yes Yes 6 8 2 2
R:R:G78 R:R:W76 8.44 0 No Yes 5 8 1 2
R:R:D77 R:R:S129 5.89 1 No Yes 9 7 2 2
R:R:D77 R:R:Y131 8.05 1 No Yes 9 5 2 1
R:R:W79 R:R:Y98 5.79 1 Yes Yes 6 4 1 2
R:R:F99 R:R:W79 11.02 1 Yes Yes 5 6 1 1
R:R:W79 R:R:Y131 12.54 1 Yes Yes 6 5 1 1
R:R:L80 R:R:P96 8.21 1 Yes Yes 5 9 2 2
R:R:L80 R:R:V108 4.47 1 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 8.21 1 Yes Yes 5 5 2 1
R:R:P96 R:R:Y98 15.3 1 Yes Yes 9 4 2 2
R:R:F102 R:R:P96 4.33 1 Yes Yes 4 9 1 2
R:R:P96 R:R:Y131 4.17 1 Yes Yes 9 5 2 1
R:R:F99 R:R:Y98 6.19 1 Yes Yes 5 4 1 2
R:R:D101 R:R:F99 3.58 1 Yes Yes 4 5 1 1
R:R:F102 R:R:F99 13.93 1 Yes Yes 4 5 1 1
R:R:D101 R:R:F102 4.78 1 Yes Yes 4 4 1 1
R:R:D101 R:R:N135 9.42 1 Yes Yes 4 3 1 1
R:R:C134 R:R:F102 12.57 0 No Yes 9 4 2 1
R:R:F102 R:R:N135 3.62 1 Yes Yes 4 3 1 1
R:R:D103 R:R:P104 6.44 0 Yes No 3 3 2 1
R:R:D103 R:R:K141 5.53 0 Yes No 3 3 2 1
R:R:E294 R:R:P104 4.72 0 No No 3 3 1 1
R:R:V108 R:R:Y131 13.88 1 Yes Yes 7 5 2 1
R:R:F119 R:R:W128 4.01 0 No Yes 4 5 2 1
R:R:H121 R:R:P122 6.1 7 Yes No 4 5 1 2
R:R:E123 R:R:H121 8.62 7 No Yes 4 4 1 1
R:R:H121 R:R:W128 17.98 7 Yes Yes 4 5 1 1
R:R:N124 R:R:R126 10.85 7 No No 5 4 1 2
R:R:N130 R:R:W128 12.43 7 Yes Yes 8 5 2 1
H:H:?2 R:R:W128 7.13 7 Yes Yes 0 5 2 1
R:R:S129 R:R:Y131 10.17 1 Yes Yes 7 5 2 1
H:H:?2 R:R:N130 22.1 7 Yes Yes 0 8 2 2
R:R:C134 R:R:Y131 4.03 0 No Yes 9 5 2 1
R:R:L142 R:R:Y146 11.72 0 No No 2 2 1 1
R:R:D373 R:R:L148 5.43 0 No Yes 5 5 2 1
R:R:L148 R:R:Y374 3.52 16 Yes Yes 5 6 1 2
R:R:H377 R:R:L148 14.14 16 Yes Yes 7 5 1 1
R:R:Y149 R:R:Y150 10.92 0 Yes No 5 4 1 2
R:R:I153 R:R:Y149 6.04 0 No Yes 7 5 2 1
R:R:L202 R:R:Y149 7.03 0 No Yes 7 5 2 1
R:R:A152 R:R:H381 7.32 0 No Yes 7 9 2 1
R:R:H156 R:R:I198 9.28 0 Yes No 7 7 2 2
R:R:H156 R:R:H381 10.75 0 Yes Yes 7 9 2 1
R:R:H226 R:R:I197 3.98 0 No No 6 5 1 2
R:R:H226 R:R:I198 5.3 0 No No 6 7 1 2
R:R:H201 R:R:V205 9.69 0 No No 6 7 1 2
R:R:P207 R:R:V206 3.53 0 No No 3 3 2 1
R:R:L291 R:R:V212 4.47 0 Yes No 6 3 1 2
R:R:M230 R:R:Y234 3.59 5 No Yes 6 7 1 1
R:R:H302 R:R:M230 5.25 5 Yes No 6 6 1 1
R:R:M237 R:R:Y234 4.79 5 Yes Yes 9 7 2 1
R:R:V305 R:R:Y234 12.62 0 No Yes 7 7 2 1
R:R:L309 R:R:Y234 3.52 5 No Yes 7 7 2 1
R:R:F356 R:R:Y234 14.44 5 Yes Yes 7 7 1 1
R:R:M237 R:R:Q383 8.16 5 Yes Yes 9 9 2 2
R:R:H296 R:R:Y299 3.27 0 No Yes 2 7 2 1
R:R:H302 R:R:L298 3.86 5 Yes No 6 6 1 2
R:R:F356 R:R:L309 3.65 5 Yes No 7 7 1 2
R:R:F356 R:R:Q355 12.88 5 Yes Yes 7 8 1 2
R:R:Q355 R:R:Q383 11.52 5 Yes Yes 8 9 2 2
R:R:F356 R:R:I380 5.02 5 Yes No 7 6 1 2
R:R:F356 R:R:Q383 4.68 5 Yes Yes 7 9 1 2
R:R:F359 R:R:M376 4.98 0 No Yes 6 7 2 1
R:R:G369 R:R:R362 6 0 No Yes 4 4 2 1
R:R:R362 R:R:Y372 8.23 0 Yes No 4 7 1 2
R:R:D373 R:R:R362 13.1 0 No Yes 5 4 2 1
R:R:M376 R:R:Y372 10.78 0 Yes No 7 7 1 2
R:R:I380 R:R:M376 4.37 0 No Yes 6 7 2 1
R:R:H377 R:R:H381 9.55 16 Yes Yes 7 9 1 1
R:R:H381 R:R:I380 5.3 0 Yes No 9 6 1 2
R:R:C289 R:R:L291 3.17 0 No Yes 9 6 2 1
R:R:L291 R:R:V205 2.98 0 Yes No 6 7 1 2
L:L:A13 R:R:H201 2.93 0 No No 0 6 0 1
L:L:F15 R:R:A145 2.77 0 Yes No 0 4 0 1
R:R:G209 R:R:N208 1.7 0 No No 3 3 1 2
R:R:M306 R:R:P360 1.68 0 No No 4 5 1 2
L:L:P29 R:R:N135 1.63 0 No Yes 0 3 0 1
L:L:A5 R:R:M376 1.61 0 No Yes 0 7 0 1
R:R:G209 R:R:R213 1.5 0 No No 3 2 1 2
R:R:N135 R:R:T138 1.46 1 Yes No 3 2 1 2
R:R:F99 R:R:P100 1.44 1 Yes No 5 4 1 2
E:E:E74 E:E:N78 1.31 1 No No 5 1 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
85.19Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
75.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
73.53Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
73.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
68.75Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
64.52Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
63.33Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
62.07Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
61.29Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
61.11Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
58.82Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
56.67Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
52.94Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
48.65Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
48.48Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
48.39Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
48.39Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
47.06Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
45.45Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
45.16Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
44.44Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
44.44Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
43.24Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
42.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
42.42Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
42.11Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
41.38Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
41.18Single6FJ3PTH6FJ3-PTH1-PTH
41.18Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
40.54Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
40.00Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
40.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
40.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
39.47Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.39Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
39.39Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
39.39Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
39.39Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
39.02Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
38.89Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
38.89Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
38.89Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
38.89Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
38.46Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
38.24Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
38.24Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
37.84Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
37.84Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
37.50Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
37.14Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
37.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
37.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
37.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
37.14Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
36.11Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
36.11Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
36.11Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
36.11Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
36.11Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
35.90Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
35.29Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
35.29Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
35.14Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
35.14Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
35.14Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
35.14Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
35.14Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
35.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
34.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
34.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
34.29Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
34.29Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
34.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
34.21Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
33.33Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
33.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
33.33Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
33.33Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
33.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
33.33Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
32.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
32.43Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
32.35Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
32.26Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
31.58Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
31.58Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
31.43Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
31.43Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
30.30Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
29.73Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
29.63Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
29.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
29.41Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.27Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
29.27Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
29.03Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.95Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
28.57Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
28.21Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
28.12Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
27.78Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
27.78Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
27.59Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
27.59Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
27.59Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
27.59Single8T1WCVN4248T1W-GPR6-CVN424
27.59Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
27.59Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
27.59Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
27.59Consensushca_on_gpOrthosteric Ligandhca2_on_gp
27.27Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.83Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
26.67Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
26.67Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
26.47Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
26.47Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
26.47Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
26.32Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
25.93Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
25.93Single8K5BNiacin8K5B-HCA2-Niacin
25.81Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
25.81Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
25.81Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
25.81Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
25.81Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
25.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
25.71Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
25.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
25.71Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
25.71Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
25.71Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
25.64Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
25.64Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
25.58Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
25.58Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
25.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
25.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
25.00Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
24.39Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.39Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.39Consensusbombesin_onOrthosteric Ligandbb2_on
24.39Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
24.39Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.32Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.32Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
24.32Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
24.32Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.32Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.24Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
24.24Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
24.24Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
24.24Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
24.24Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
24.24Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
24.14Single2YDOAdenosine2YDO-A2A-Adenosine
24.14Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
24.14Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
24.14Single8K5CAcipimox8K5C-HCA2-Acipimox
24.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
24.14Consensushca_onOrthosteric Ligandhca2_on
23.68Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
23.68Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
23.68Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
23.68Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.68Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.68Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.53Single3NY9ICI118-5513NY9-β2-ICI118-551
23.53Single4UG2CGS216804UG2-A2A-CGS21680
23.53Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.53Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
23.53Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
23.53Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
23.53Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
23.53Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.53Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
23.53Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
23.33Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
23.33Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
23.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.33Single8K5DGSK2560738K5D-HCA2-GSK256073
23.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
23.33Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
23.33Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
23.33Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
23.08Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
23.08Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
23.08Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
22.86Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
22.86Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
22.86Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
22.86Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.58Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
22.58Single6PS6Timolol6PS6-β2-Timolol
22.58Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
22.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
22.58Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
22.58Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
22.58Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
22.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Consensustrace-amine_onOrthosteric Ligandta1_on
22.50Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.50Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
22.50Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
22.50Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
22.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
22.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
22.22Single3QAKUK-4320973QAK-A2A-UK-432097
22.22Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.22Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
22.22Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
22.22Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
22.22Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
22.22Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.22Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
21.95Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.95Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.95Consensusbradykinin_onOrthosteric Ligandbk2_on
21.95Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
21.95Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.88Single2YDVNECA2YDV-A2A-NECA
21.88Single4UHRCGS216804UHR-A2A-CGS21680
21.88Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
21.88Single5G53NECA5G53-A2A-NECA-Gs
21.88Single5V54Methiothepin5V54-5-HT1B-Methiothepin
21.88Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.88Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
21.88Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
21.88Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
21.88Consensus5ht1_offOrthosteric Ligand5ht1b_off
21.88Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
21.88Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.88Consensusrelaxin_onOrthosteric Ligandrxfp4_on
21.88Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
21.88Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.88Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
21.62Single5WF5UK-4320975WF5-A2A-UK-432097
21.62Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.62Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
21.62Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
21.62Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
21.62Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
21.62Consensusangiotensin_onOrthosteric Ligandat1_on
21.62Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.62Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.62Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
21.62Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
21.62Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
21.62Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.62Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
21.62Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
21.62Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
21.43Single5GLHEndothelin-15GLH-ETB-Endothelin-1
21.43Single6IGKEndothelin-36IGK-ETB-Endothelin-3
21.43Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
21.43Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
21.43Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.21Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.21Single6A93Risperidone6A93-5-HT2A-Risperidone
21.21Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
21.21Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
21.21Single7DFPSpiperone7DFP-D2-Spiperone
21.21Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
21.21Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
21.21Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
21.21Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.21Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.21Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.21Single8XYIVUF106618XYI-CXCR3-VUF10661
21.21Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
21.21Consensuslpa_offOrthosteric Ligandlpa1_off
21.21Consensuslpl_offOrthosteric Ligands1p_off lpa_off
21.21Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.21Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.21Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.21Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.21Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
21.05Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
21.05Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.05Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
21.05Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
21.05Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.05Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.05Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.05Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.05Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
21.05Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
21.05Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.05Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.69Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.69Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.69Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
20.69Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.69Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
20.59Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
20.59Single5CGDHTL142425CGD-mGlu5-HTL14242
20.59Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.59Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
20.59Single7EZCUKA7EZC-A2A-UKA
20.59Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
20.59Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
20.59Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
20.59Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.59Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
20.59Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.59Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.59Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.59Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.59Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
20.59Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.51Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.51Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.51Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.51Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.51Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
20.51Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.51Single8ZRTET-18ZRT-ETB-ET-1
20.51Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.51Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
20.51Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
20.51Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
20.51Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
20.45Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
20.00Single4XT3Fractalkine4XT3-US28-Fractalkine
20.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single5WF6UK-4320975WF6-A2A-UK-432097
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
20.00Single7SK9CCX6627SK9-ACKR3-CCX662
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
20.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
20.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
20.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
20.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
20.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
20.00Single8X5YAstemizole8X5Y-H1-Astemizole
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
19.51Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.51Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
19.51Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.51Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.51Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.44Single4XT1Fractalkine4XT1-US28-Fractalkine
19.44Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.44Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.44Single7QA8Peptide7QA8-STE2-Peptide
19.44Single7QA8Peptide7QA8-STE2-Peptide
19.44Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
19.44Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
19.44Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.44Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.44Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
19.44Single8WDTphotoNECA8WDT-A2A-photoNECA
19.44Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.44Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
19.44Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.44Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.35Single3NY8ICI118-5513NY8-β2-ICI118-551
19.35Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
19.35Single4GBRS-Carazolol4GBR-β2-S-Carazolol
19.35Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
19.35Single5TGZAM65385TGZ-CB1-AM6538
19.35Single7UL4Alvimopan7UL4-μ-Alvimopan
19.35Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
19.35Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.35Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.35Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
19.35Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
19.35Single8JJOAlprenolol8JJO-β2-Alprenolol
19.35Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
19.35Single9CHXS-Carazolol9CHX-β2-S-Carazolol
19.35Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
19.35Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
19.35Consensusdopamine_offOrthosteric Ligandd2_off d3_off
19.35Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.05Single6IGLIRL16206IGL-ETB-IRL1620
19.05Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
19.05Consensusendothelin_onOrthosteric Ligandetb_on eta_on
18.92Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
18.92Single6HLOAprepitant6HLO-NK1-Aprepitant
18.92Single7XNACYN1548067XNA-SST2-CYN154806
18.92Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
18.92Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
18.92Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.92Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
18.92Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
18.75Single2RH1S-Carazolol2RH1-β2-S-Carazolol
18.75Single2YCWS-Carazolol2YCW-β1-S-Carazolol
18.75Single5C1MBU725C1M-μ-BU72
18.75Single5CGCHTL142425CGC-mGlu5-HTL14242
18.75Single5D6LS-Carazolol5D6L-β2-S-Carazolol
18.75Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.75Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.75Single5N2SPSB365N2S-A1-PSB36
18.75Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
18.75Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.75Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
18.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.75Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
18.75Single7C4SS1P7C4S-S1P3-S1P
18.75Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
18.75Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
18.75Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
18.75Single7SINNPS-21437SIN-CaS-NPS-2143
18.75Single7SINNPS-21437SIN-CaS-NPS-2143
18.75Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
18.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.75Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.75Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.75Single8TF5Oleic acid8TF5-GPR6-Oleic acid
18.75Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
18.75Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
18.75Single8ZMFA1L108ZMF-5-HT2C-A1L10
18.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
18.75Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
18.75Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.75Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.75Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
18.75Consensusamine_offonOrthosteric Ligandamine_off amine_on
18.75Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
18.75Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
18.75Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
18.75Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
18.75Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.75Consensusblt_offOrthosteric Ligandblt1_off
18.75Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
18.75Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.75Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
18.75Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.75Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
18.75Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.75Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
18.60Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.60Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
18.60Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
18.52Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
18.52Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
18.42Single6PT2KGCHM076PT2-δ-KGCHM07
18.42Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
18.42Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
18.42Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
18.42Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.42Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.42Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.42Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.42Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.42Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
18.18Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
18.18Single4DJHJDTic4DJH-κ-JDTic
18.18Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
18.18Single5D5AS-Carazolol5D5A-β2-S-Carazolol
18.18Single5D5BS-Carazolol5D5B-β2-S-Carazolol
18.18Single6J21Aprepitant6J21-NK1-Aprepitant
18.18Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
18.18Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
18.18Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7PX4PSB-21137PX4-A2A-PSB-2113
18.18Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
18.18Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
18.18Single7TUYGSK682753A7TUY-GPR183-GSK682753A
18.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
18.18Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
18.18Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
18.18Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
18.18Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
18.18Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
18.18Single8E0GBU728E0G-μ-BU72
18.18Single8EA0Iperoxo8EA0-M3-Iperoxo
18.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
18.18Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
18.18Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
18.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
18.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.18Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
18.18Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
18.18Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
18.18Consensusa2_onOrthosteric Liganda2b_on
18.18Consensusa2_on_gpOrthosteric Liganda2b_on_gp
18.18Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.18Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
18.18Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
18.18Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
18.18Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
18.18Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
18.18Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
18.18Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
18.18Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
18.18Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
18.18Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.18Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
18.18Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
18.18Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
17.95Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.95Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.95Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
17.95Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
17.95Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
17.95Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
17.95Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.95Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.86Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.86Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.65Single3D4STimolol3D4S-β2-Timolol
17.65Single4AMIBucindolol4AMI-β1-Bucindolol
17.65Single4N4WSANT-14N4W-SMO-SANT-1
17.65Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
17.65Single5CXVTiotropium5CXV-M1-Tiotropium
17.65Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
17.65Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
17.65Single6OS2TRV0266OS2-AT1-TRV026
17.65Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.65Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
17.65Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
17.65Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.65Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.65Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.65Single7K15MKD0467K15-BLT1-MKD046-Na
17.65Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
17.65Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.65Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.65Single7YITNalfurafine7YIT-κ-Nalfurafine
17.65Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.65Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
17.65Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.65Single8JWY2-1188JWY-A2A-2-118
17.65Single8JWZAB9288JWZ-A2A-AB928-Na
17.65Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.65Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
17.65Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
17.65Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
17.65Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.65Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
17.65Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.65Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.65Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
17.65Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
17.65Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
17.65Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
17.50Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
17.50Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.50Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
17.50Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.50Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.50Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.50Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
17.50Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.39Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.24Single3OE9IT1t3OE9-CXCR4-IT1t
17.24Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
17.24Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
17.24Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.24Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.24Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
17.24Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
17.24Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.24Single9B9Y7DY9B9Y-CB1-7DY
17.24Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.14Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
17.14Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
17.14Single5X93K-87945X93-ETB-K-8794
17.14Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
17.14Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
17.14Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
17.14Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
17.14Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
17.14Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
17.14Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.14Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensuscck_onOrthosteric Ligandccka_on cckb_on
17.14Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
17.14Consensusendothelin_offOrthosteric Ligandetb_off
17.14Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
17.14Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
17.14Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
17.14Consensusprostanoid_offOrthosteric Ligandep_off dp_off
17.14Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
17.14Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
17.14Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
17.07Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
16.67Single5ZTYAM102575ZTY-CB2-AM10257
16.67Single6B73MP11046B73-κ-MP1104
16.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
16.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
16.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
16.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
16.67Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.67Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
16.67Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.67Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
16.67Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
16.67Single7XN9L-054,5227XN9-SST2-L-054,522
16.67Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
16.67Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
16.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.67Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
16.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.67Single8IWESpermidine8IWE-TA9-Spermidine
16.67Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
16.67Single8QJ2pN1628QJ2-MC4-pN162-Gs
16.67Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
16.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
16.67Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.67Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
16.67Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
16.67Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
16.67Single9BA0A1AKN9BA0-CB1-A1AKN
16.67Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
16.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
16.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.67Consensusangiotensin_offOrthosteric Ligandat1_off
16.67Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
16.67Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
16.67Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
16.67Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
16.67Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
16.67Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
16.67Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
16.67Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.67Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
16.28Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
16.28Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.28Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
16.22Single7F8XNN90567F8X-CCKA-NN9056
16.22Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
16.22Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.22Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
16.22Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
16.22Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.22Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
16.22Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
16.22Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.22Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
16.22Consensuslpl_onOrthosteric Ligands1p_on lpa_on
16.22Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
16.22Consensussomatostatin_offOrthosteric Ligandsst2_off
16.13Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
16.13Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.13Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
16.13Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.13Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.13Single5JTBZM-2413855JTB-A2A-ZM-241385
16.13Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.13Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
16.13Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
16.13Single6PS0S-Carazolol6PS0-β2-S-Carazolol
16.13Single6PS4ICI118-5516PS4-β2-ICI118-551
16.13Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.13Single6TPGEMPA6TPG-OX2-EMPA
16.13Single6V9SGTPL114036V9S-OX1-GTPL11403
16.13Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
16.13Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.13Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
16.13Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
16.13Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
16.13Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
16.13Single7T32ZM-2413857T32-A2A-ZM-241385
16.13Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
16.13Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
16.13Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
16.13Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
16.13Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
16.13Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
16.13Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
16.13Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
16.13Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
16.13Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.13Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
16.13Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
16.13Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
16.13Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
16.13Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.13Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
16.13Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
16.13Consensusa2_offOrthosteric Liganda2a_off
16.13Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.13Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
16.13Consensusalpha1_onOrthosteric Ligandalpha1a_on
16.13Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
16.13Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
16.13Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
16.13Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
16.13Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.13Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.13Consensusgrh_offOrthosteric Ligandgnrh1_off
15.91Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.79Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.79Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
15.79Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.79Single7SK5CXCL127SK5-ACKR3-CXCL12
15.79Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
15.62Single2Y04Salbutamol2Y04-β1-Salbutamol
15.62Single3EMLZM-2413853EML-A2A-ZM-241385
15.62Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
15.62Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
15.62Single4DAJTiotropium4DAJ-M3-Tiotropium
15.62Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
15.62Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.62Single4EJ4Naltrindole4EJ4-δ-Naltrindole
15.62Single4QKX35V4QKX-β2-35V
15.62Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.62Single4YAYZD-71554YAY-AT1-ZD-7155
15.62Single5DHHSB-6121115DHH-NOP-SB-612111
15.62Single5DSGTiotropium5DSG-M4-Tiotropium
15.62Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.62Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.62Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.62Single5UENDU1725UEN-A1-DU172
15.62Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.62Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
15.62Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
15.62Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
15.62Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.62Single6GPSMK08126GPS-CCR2-MK0812
15.62Single6H7MSalbutamol6H7M-β1-Salbutamol
15.62Single6IIVDaltroban6IIV-TP-Daltroban
15.62Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.62Single6PS1Timolol6PS1-β2-Timolol
15.62Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
15.62Single6S0LZM-2413856S0L-A2A-ZM-241385
15.62Single6TOTLemborexant6TOT-OX1-Lemborexant
15.62Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.62Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.62Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
15.62Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.62Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
15.62Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.62Single7PYRPSB-21157PYR-A2A-PSB-2115
15.62Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.62Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
15.62Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.62Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
15.62Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
15.62Single7WC7Lisuride7WC7-5-HT2A-Lisuride
15.62Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.62Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.62Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
15.62Single8CU6LJ-45178CU6-A2A-LJ-4517
15.62Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
15.62Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
15.62Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
15.62Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
15.62Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
15.62Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
15.62Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
15.62Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
15.62Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
15.62Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
15.62Single8JXRLSD8JXR-D1-LSD
15.62Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
15.62Single8RLNLUF58348RLN-A2A-LUF5834
15.62Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
15.62Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.62Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
15.62Single8X63Mepyramine8X63-H1-Mepyramine
15.62Single8X64Desloratadine8X64-H1-Desloratadine
15.62Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
15.62Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
15.62Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.62Single9B9ZA1AKO9B9Z-CB1-A1AKO
15.62Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
15.62Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
15.62Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.62Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
15.62Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
15.62Consensusa3_onOrthosteric Liganda3a_on
15.62Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
15.62Consensusalpha2_onOrthosteric Ligandalpha2b_on
15.62Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
15.62Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.62Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
15.62Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
15.62Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
15.62Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
15.62Consensusblt_onOrthosteric Ligandblt1_on
15.62Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
15.62Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.62Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
15.62Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
15.62Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
15.62Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.62Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
15.62Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
15.62Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
15.62Consensushistamine_offOrthosteric Ligandh1_off
15.62Consensusleukotriene_onOrthosteric Ligandblt_on
15.62Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
15.62Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
15.62Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
15.62Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
15.62Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
15.56Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.38Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
15.38Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
15.38Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
15.38Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
15.22Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
15.15Single2Y03Isoprenaline2Y03-β1-Isoprenaline
15.15Single4JKVTaladegib4JKV-SMO-Taladegib
15.15Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
15.15Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.15Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.15Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
15.15Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.15Single5TVNLSD5TVN-5-HT2B-LSD
15.15Single5WIUNemonapride5WIU-D4-Nemonapride
15.15Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.15Single5WQCEMPA5WQC-OX2-EMPA
15.15Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.15Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.15Single6D26Fevipiprant6D26-DP2-Fevipiprant
15.15Single6GPXMK08126GPX-CCR2-MK0812
15.15Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
15.15Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
15.15Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.15Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
15.15Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
15.15Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
15.15Single6S0QZM-2413856S0Q-A2A-ZM-241385
15.15Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
15.15Single6TP6Filorexant6TP6-OX1-Filorexant
15.15Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.15Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
15.15Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
15.15Single7C61Ergotamine7C61-5-HT1B-Ergotamine
15.15Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
15.15Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.15Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
15.15Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
15.15Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.15Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
15.15Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.15Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
15.15Single7W41PD1762527W41-BB2-PD176252
15.15Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
15.15Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
15.15Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
15.15Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
15.15Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
15.15Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
15.15Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.15Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
15.15Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
15.15Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.15Single8QOTNanobody-E8QOT-μ-Nanobody-E
15.15Single8S4DCMF-0198S4D-Apelin-CMF-019
15.15Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.15Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
15.15Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
15.15Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
15.15Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
15.15Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
15.15Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
15.15Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
15.15Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
15.15Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
15.15Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.15Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
15.15Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.15Consensusa3_on_gpOrthosteric Liganda3a_on_gp
15.15Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.15Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.15Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
15.15Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
15.15Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
15.15Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
15.15Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
15.15Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
15.15Consensusbombesin_offOrthosteric Ligandbb2_off
15.15Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.15Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.15Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
15.15Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.15Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.15Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
15.15Consensusdp_offOrthosteric Liganddp2_off
15.15Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.15Consensusep_offOrthosteric Ligandep4_off
15.15Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
15.15Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.00Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
15.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
15.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
15.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.81Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
14.71Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
14.71Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.71Single4U15Tiotropium4U15-M3-Tiotropium
14.71Single5V56TC1145V56-SMO-TC114
14.71Single5V57TC1145V57-SMO-TC114
14.71Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
14.71Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
14.71Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
14.71Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
14.71Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
14.71Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.71Single6OL9Tiotropium6OL9-M5-Tiotropium
14.71Single6WGTLSD6WGT-5-HT2A-LSD
14.71Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
14.71Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
14.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
14.71Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
14.71Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
14.71Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
14.71Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
14.71Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
14.71Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
14.71Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
14.71Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
14.71Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
14.71Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.71Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
14.71Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
14.71Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
14.71Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
14.71Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
14.71Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
14.71Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.71Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
14.71Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
14.71Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
14.71Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.71Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
14.71Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
14.71Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
14.71Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
14.71Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.71Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.71Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
14.71Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
14.71Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
14.71Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
14.71Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.71Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
14.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.63Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.63Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
14.29Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
14.29Single4LDEBI1671074LDE-β2-BI167107
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single4XEENeurotensin4XEE-NTS1-Neurotensin
14.29Single4XESNeurotensin4XES-NTS1-Neurotensin
14.29Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
14.29Single6CM4Risperidone6CM4-D2-Risperidone
14.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
14.29Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.29Single6YVRNTS8-136YVR-NTS1-NTS8-13
14.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
14.29Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
14.29Single7SK3CXCL127SK3-ACKR3-CXCL12
14.29Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
14.29Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
14.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
14.29Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
14.29Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
14.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.29Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
14.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
14.29Single8JJ8Formoterol8JJ8-β2-Formoterol
14.29Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
14.29Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.29Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
14.29Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
14.29Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.29Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.29Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.29Consensusalpha1_offOrthosteric Ligandalpha1a_off
14.29Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
14.29Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
14.29Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
14.29Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
14.29Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
14.29Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
14.29Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
14.29Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
14.29Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
14.29Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.29Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
14.29Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
14.29Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
14.29Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
14.29Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
14.29Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.29Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
14.29Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
14.29Consensusorexin_onOrthosteric Ligandox2_on
14.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
14.29Consensussensory_onOrthosteric Ligandopsins_on
13.95Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
13.89Single4BUONeurotensin4BUO-NTS1-Neurotensin
13.89Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.89Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
13.89Single6H7LDobutamine6H7L-β1-Dobutamine
13.89Single6IBLArformoterol6IBL-β1-Arformoterol
13.89Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
13.89Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.89Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.89Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
13.89Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
13.89Single7UM4AS26747237UM4-5-HT5A-AS2674723
13.89Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
13.89Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
13.89Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
13.89Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
13.89Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
13.89Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.89Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
13.89Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
13.89Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
13.89Single8XVJMacitentan8XVJ-ETA-Macitentan
13.89Single8XVUCXCL28XVU-CXCR2-CXCL2
13.89Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
13.89Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
13.89Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.89Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.89Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.89Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.89Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
13.89Consensuschemerin_onOrthosteric Ligandcml1_on
13.89Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
13.89Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
13.79Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
13.79Single3OE6IT1t3OE6-CXCR4-IT1t
13.79Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.79Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
13.79Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
13.79Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
13.79Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
13.79Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.79Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
13.79Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.79Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.79Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.79Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.79Consensusgi_sensoryOrthosteric Ligandgi_opsins
13.79Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.79Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
13.79Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
13.79Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
13.64Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
13.64Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.64Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
13.51Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
13.51Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
13.51Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.51Single6PT3DPI-2876PT3-δ-DPI-287
13.51Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
13.51Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
13.51Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.51Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
13.51Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
13.51Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
13.51Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
13.51Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
13.33Single4O9RCyclopamine4O9R-SMO-Cyclopamine
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single6LI0C176LI0-GPR52-C17
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
13.33Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
13.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
13.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
13.33Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
13.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
13.33Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
13.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.33Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
13.33Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.33Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.33Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.33Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
13.33Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.33Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.33Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
13.16Single4IARErgotamine4IAR-5-HT1B-Ergotamine
13.16Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
13.16Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
13.16Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
13.16Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
13.16Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.16Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
13.16Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
13.04Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
13.04Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
13.04Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
13.04Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
12.90Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
12.90Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.90Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.90Single3ODUIT1t3ODU-CXCR4-IT1t
12.90Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.90Single4BWBNeurotensin4BWB-NTS1-Neurotensin
12.90Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
12.90Single4QINSAG1.54QIN-SMO-SAG1.5
12.90Single4S0VSuvorexant4S0V-OX2-Suvorexant
12.90Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
12.90Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
12.90Single5U09Taranabant5U09-CB1-Taranabant
12.90Single5WS3EMPA5WS3-OX2-EMPA
12.90Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.90Single6AKXA4R6AKX-CCR5-A4R
12.90Single6AKYMaraviroc6AKY-CCR5-Maraviroc
12.90Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
12.90Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
12.90Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.90Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
12.90Single6TODEMPA6TOD-OX1-EMPA-Na
12.90Single6TPJSuvorexant6TPJ-OX2-Suvorexant
12.90Single7BR3Elagolix7BR3-GnRH1-Elagolix
12.90Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.90Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.90Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
12.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
12.90Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
12.90Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.90Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.90Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
12.90Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
12.90Single8GNGIstradefylline8GNG-A2A-Istradefylline
12.90Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
12.90Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
12.90Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
12.90Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
12.90Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.90Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
12.90Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
12.90Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
12.90Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
12.90Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.90Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
12.90Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.90Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.90Consensusorexin_offOrthosteric Ligandox2_off ox1_off
12.90Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
12.90Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
12.90Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
12.90Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.90Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
12.82Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
12.82Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
12.82Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
12.82Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
12.82Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
12.82Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
12.82Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
12.82Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
12.73Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
12.50Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
12.50Single3OE0CVX153OE0-CXCR4-CVX15
12.50Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
12.50Single4MBSMaraviroc4MBS-CCR5-Maraviroc
12.50Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
12.50Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
12.50Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
12.50Single5IUBQ274563445IUB-A2A-Q27456344-Na
12.50Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
12.50Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
12.50Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
12.50Single5UVIZM-2413855UVI-A2A-ZM-241385
12.50Single6A94Zotepine6A94-5-HT2A-Zotepine
12.50Single6AQFZM-2413856AQF-A2A-ZM-241385
12.50Single6FFIMMPEP6FFI-mGlu5-MMPEP
12.50Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.50Single6KUXRS-799486KUX-α2a-RS-79948
12.50Single6MH8ZM-2413856MH8-A2A-ZM-241385
12.50Single6PS5S-Propranolol6PS5-β2-S-Propranolol
12.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
12.50Single6TP3Nemorexant6TP3-OX1-Nemorexant
12.50Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
12.50Single6VI4JDTic6VI4-κ-JDTic
12.50Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
12.50Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.50Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
12.50Single7AROLUF58337ARO-A2A-LUF5833-Na
12.50Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
12.50Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.50Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
12.50Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
12.50Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
12.50Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
12.50Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
12.50Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
12.50Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
12.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
12.50Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
12.50Single7UL3Famotidine7UL3-H2-Famotidine
12.50Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.50Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
12.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
12.50Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
12.50Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.50Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.50Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
12.50Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
12.50Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
12.50Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
12.50Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
12.50Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
12.50Single8K2WAMG4878K2W-CXCR3-AMG487
12.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
12.50Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
12.50Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
12.50Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
12.50Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
12.50Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
12.50Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
12.50Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
12.50Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
12.50Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
12.50Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
12.50Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
12.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
12.50Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
12.50Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
12.50Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
12.50Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
12.50Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.50Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.50Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
12.50Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
12.50Consensusopsins_offOrthosteric Ligandrhodopsin_off
12.50Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.50Consensussensory_offOrthosteric Ligandopsins_off
12.20Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.20Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
12.20Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
12.20Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
12.12Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
12.12Single2Y01Dobutamine2Y01-β1-Dobutamine
12.12Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
12.12Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
12.12Single4MQSIperoxo4MQS-M2-Iperoxo
12.12Single4U14Tiotropium4U14-M3-Tiotropium
12.12Single5DHGC-355DHG-NOP-C-35
12.12Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
12.12Single5T04Neurotensin5T04-NTS1-Neurotensin
12.12Single6D27CAY104716D27-DP2-CAY10471
12.12Single6FFHFenobam6FFH-mGlu5-Fenobam
12.12Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
12.12Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
12.12Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
12.12Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
12.12Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
12.12Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
12.12Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
12.12Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
12.12Single7BU7BI1671077BU7-β1-BI167107
12.12Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
12.12Single7F83PF-051904577F83-Ghrelin-PF-05190457
12.12Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.12Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
12.12Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
12.12Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
12.12Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
12.12Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
12.12Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
12.12Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.12Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.12Single7V3ZCP559407V3Z-CB1-CP55940
12.12Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
12.12Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.12Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
12.12Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
12.12Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
12.12Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
12.12Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
12.12Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
12.12Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
12.12Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
12.12Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.12Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
12.12Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
12.12Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.12Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
12.12Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
12.12Consensus5ht5_onOrthosteric Ligand5ht5a_on
12.12Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.12Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
12.12Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
12.12Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
12.12Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
12.12Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.12Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
12.12Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
12.12Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.76Single2Y00Dobutamine2Y00-β1-Dobutamine
11.76Single6E67BI1671076E67-β2-BI167107-Gs (fused)
11.76Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
11.76Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.76Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.76Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.76Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
11.76Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.76Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
11.76Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
11.76Single7WC6LSD7WC6-5-HT2A-LSD
11.76Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
11.76Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.76Single8JXSPF-61428JXS-D1-PF-6142
11.76Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.76Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
11.76Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.76Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
11.76Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.76Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
11.76Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.76Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
11.76Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
11.76Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
11.63Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
11.43Single3P0GBI1671073P0G-β2-BI167107
11.43Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
11.43Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
11.43Single4BV0Neurotensin4BV0-NTS1-Neurotensin
11.43Single5XR8AM8415XR8-CB1-AM841
11.43Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
11.43Single6J20Aprepitant6J20-NK1-Aprepitant
11.43Single6OS1TRV0266OS1-AT1-TRV026
11.43Single7B6WCyclazosin7B6W-α1b-Cyclazosin
11.43Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
11.43Single7F1TMIP-1a7F1T-CCR5-MIP-1a
11.43Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
11.43Single7FEECP559407FEE-CB1-CP55940-ZCZ011
11.43Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
11.43Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
11.43Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
11.43Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
11.43Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
11.43Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
11.43Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
11.43Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
11.43Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
11.43Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
11.43Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
11.43Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
11.43Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
11.43Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
11.43Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
11.43Single8XVLZibotentan8XVL-ETA-Zibotentan
11.43Single9BJKNAM9BJK-μ-Naloxone-NAM
11.43Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
11.43Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
11.43Consensuslpa_onOrthosteric Ligandlpa1_on
11.43Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
11.43Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusneurotensin_onOrthosteric Ligandnts1_on
11.43Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
11.43Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
11.43Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.43Consensustachykinin_offOrthosteric Ligandnk1_off
11.11Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
11.11Single4RWADIPP-NH24RWA-δ-DIPP-NH2
11.11Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
11.11Single6KQICP559406KQI-CB1-CP55940-Org27569
11.11Single6MXTSalmeterol6MXT-β2-Salmeterol
11.11Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
11.11Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.11Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
11.11Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JJLOlodaterol8JJL-β2-Olodaterol
11.11Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
11.11Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
11.11Single8XWMCXCL68XWM-CXCR2-CXCL6
11.11Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
11.11Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
11.11Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
11.11Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.11Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
11.11Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
11.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.87Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
10.81Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
10.81Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
10.81Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
10.81Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
10.81Single6K1QIRL25006K1Q-ETB-IRL2500
10.81Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
10.81Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.81Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
10.81Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
10.81Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
10.81Single8XWFCXCL38XWF-CXCR2-CXCL3
10.81Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.81Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
10.81Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
10.71Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
10.71Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
10.71Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
10.71Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.71Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
10.71Single8HS2Fab0468HS2-GPR20-Fab046
10.71Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
10.71Single8PWNTheophylline8PWN-A2A-Theophylline
10.71Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
10.53Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
10.53Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
10.53Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
10.53Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
10.53Single8IEIA1LYA8IEI-GPR156-A1LYA
10.53Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8XQJJN2418XQJ-Apelin-JN241
10.53Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
10.34Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.34Single3OE8IT1t3OE8-CXCR4-IT1t
10.34Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.34Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.34Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.34Single8A2OTheophylline8A2O-A2A-Theophylline-Na
10.34Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.34Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
10.34Single9CHUNoradrenaline9CHU-β2-Noradrenaline
10.26Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
10.26Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
10.26Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
10.26Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
10.26Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.26Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
10.26Single8IEBA1LYA8IEB-GPR156-A1LYA
10.26Single8IEIA1LYA8IEI-GPR156-A1LYA
10.26Single8IEPA1LYA8IEP-GPR156-A1LYA
10.26Single8IEPA1LYA8IEP-GPR156-A1LYA
10.26Single8XWNCXCL88XWN-CXCR2-CXCL8
10.26Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
10.26Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
10.26Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.26Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
10.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.00Single3UZAGTPL92363UZA-A2A-GTPL9236
10.00Single4XNWMRS25004XNW-P2Y1-MRS2500
10.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
10.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.00Single8IEBA1LYA8IEB-GPR156-A1LYA
10.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
10.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
10.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
10.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.00Consensus5ht2_onOrthosteric Ligand5ht2b_on
10.00Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
10.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
9.76Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
9.68Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.68Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.68Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.68Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.68Single3PBLEticlopride3PBL-D3-Eticlopride
9.68Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
9.68Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.68Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
9.68Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.68Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.68Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
9.68Single7SRQLSD7SRQ-5-HT2B-LSD
9.68Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
9.68Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.68Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
9.68Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.68Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
9.68Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.68Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
9.68Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.68Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
9.68Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
9.68Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.68Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.68Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.68Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
9.68Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
9.68Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
9.68Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.68Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
9.68Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
9.68Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.52Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
9.38Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.38Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.38Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.38Single3PWHZM-2413853PWH-A2A-ZM-241385
9.38Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
9.38Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.38Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.38Single6ME2Ramelteon6ME2-MT1-Ramelteon
9.38Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.38Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.38Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
9.38Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
9.38Single7F8ULintitript7F8U-CCKA-Lintitript
9.38Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.38Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
9.38Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.38Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
9.38Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.38Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.38Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
9.38Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
9.38Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
9.38Single7XRRLemborexant7XRR-OX2-Lemborexant
9.38Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.38Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.38Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.38Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
9.38Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
9.38Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
9.38Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
9.38Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
9.38Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
9.38Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
9.38Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.38Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
9.38Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
9.38Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
9.38Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.38Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
9.38Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.38Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
9.38Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.38Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.30Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
9.30Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
9.30Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
9.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.09Single3RZECidoxepin3RZE-H1-Cidoxepin
9.09Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
9.09Single6IQLL7458706IQL-D4-L745870
9.09Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
9.09Single6TPKRetosiban6TPK-OT-Retosiban
9.09Single6TPNHTL66416TPN-OX2-HTL6641
9.09Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.09Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.09Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.09Single7VV6C48/807VV6-MRGPRX2-C48/80
9.09Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
9.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.09Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.09Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
9.09Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.09Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.09Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
9.09Consensusvasop-oxy_offOrthosteric Ligandot_off
8.89Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
8.82Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.82Single2Y02Carmoterol2Y02-β1-Carmoterol
8.82Single4QIMANTA XV4QIM-SMO-ANTA XV
8.82Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
8.82Single6DRXLisuride6DRX-5-HT2B-Lisuride
8.82Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
8.82Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
8.82Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
8.82Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
8.82Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
8.82Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
8.82Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
8.82Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
8.82Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.82Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
8.82Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
8.82Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
8.82Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.82Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.82Consensuscck_offOrthosteric Ligandccka_off
8.82Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
8.82Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
8.82Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.82Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.82Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.82Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
8.70Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
8.57Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
8.57Single5XPRBosentan5XPR-ETB-Bosentan
8.57Single6HLPNetupitant6HLP-NK1-Netupitant
8.57Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
8.57Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
8.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.57Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.57Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.57Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.57Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.57Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.57Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.57Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
8.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
8.33Single5XRAAM115425XRA-CB1-AM11542
8.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
8.33Single6E59L-7607356E59-NK1-L-760735
8.33Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
8.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.33Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
8.33Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.33Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.11Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.11Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
8.11Single8XQJJN2418XQJ-Apelin-JN241
8.11Single8XWACXCL18XWA-CXCR2-CXCL1
8.11Single8XWSCXCL58XWS-CXCR2-CXCL5
8.11Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.11Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
7.89Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
7.89Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
7.89Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.89Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.89Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single6KNMJN241-96KNM-Apelin-JN241-9
7.69Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
7.69Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
7.69Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.69Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.69Consensuskisspeptin_onOrthosteric Ligandkiss1_on
7.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.50Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.50Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.50Single8KIGSHU91198KIG-MC3-SHU9119-Ca
7.50Single8WKYPG-9348WKY-MC4-PG-934
7.50Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.50Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.50Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.50Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.50Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
7.50Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
7.32Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
7.32Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.32Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
7.14Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.14Single6W25SHU91196W25-MC4-SHU9119-Ca
7.14Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.14Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.14Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.14Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.14Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
6.98Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
6.98Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
6.90Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
6.90Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.90Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.90Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.82Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
6.82Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.67Single3RFMCaffeine3RFM-A2A-Caffeine
6.67Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
6.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.67Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.67Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
6.67Consensusp2y_offOrthosteric Ligandp2y1_off
6.45Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.45Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.45Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
6.45Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.45Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
6.45Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.45Single8JPSCCL78JPS-ACKR1-CCL7
6.45Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
6.25Single6HLLCP999946HLL-NK1-CP99994
6.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
6.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.25Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
6.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
6.25Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
6.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
6.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
6.25Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.25Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.06Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.06Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.06Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.06Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.06Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
6.06Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6.06Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.06Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.06Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.06Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.06Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
5.88Single3REYXAC3REY-A2A-XAC
5.88Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
5.88Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.88Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
5.71Single4Z9GCP-3763954Z9G-CRF1-CP-376395
5.71Single5UIGCmpd-15UIG-A2A-Cmpd-1
5.71Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.71Single8GTIBMK-C2058GTI-CRF1-BMK-C205
5.71Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
5.71Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
5.71Single9IYAONO-97105319IYA-GPR55-ONO-9710531
5.56Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
5.56Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.56Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.56Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.56Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.56Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
5.41Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
5.41Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
5.41Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
5.41Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.41Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.26Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
5.26Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.26Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.26Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.13Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.13Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
5.13Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
5.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
5.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
5.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
5.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
4.88Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.88Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
4.76Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
4.76Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.76Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
4.65Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
4.65Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
3.85Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.85Single6D35Cholesterol6D35-SMO-Cholesterol
3.85Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.85Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.85Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.85Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.85Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.85Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.85Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.85Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.85Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.85Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.85Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.85Single7DTTCa7DTT-CaS-Ca-Ca
3.85Single7DTTCa7DTT-CaS-Ca-Ca
3.85Single7DTUTryptophan7DTU-CaS-Tryptophan
3.85Single7DTUTryptophan7DTU-CaS-Tryptophan
3.85Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.85Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.85Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.85Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.85Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.85Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.85Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.85Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.85Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.85Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.85Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.85Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.85Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.85Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.85Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.85Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.85Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.85Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.85Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.85Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.85Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
3.85Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.85Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.85Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.85Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.85Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.85Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.85Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.85Single7XW7K1-707XW7-TSH-K1-70
3.85Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.85Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.85Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.85Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.85Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.85Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.85Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.85Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.85Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.85Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.85Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.85Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.85Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.85Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.85Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.85Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.85Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.85Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.85Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.85Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.85Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.85Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.85Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.85Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.85Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.85Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.85Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.85Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.85Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.85Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.85Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.85Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.85Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.85Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.85Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.85Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.85Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.85Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.85Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
3.85Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
3.85Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.85Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
3.85Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.85Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8WVXNorrin8WVX-LGR4-Norrin
3.85Single8WVYNorrin8WVY-LGR4-Norrin
3.85Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.85Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.85Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.85Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.85Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.85Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.85Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.85Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.57Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.57Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.57Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.57Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
3.45Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.45Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.45Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.45Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.45Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.45Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single5L7DCholesterol5L7D-SMO-Cholesterol
3.33Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.33Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.33Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.33Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.23Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.12Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.12Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.12Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.03Single6TP4ACT-4622066TP4-OX1-ACT-462206
3.03Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.03Single7UL2SR486927UL2-NTS1-SR48692-Na
3.03Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.03Consensusneurotensin_offOrthosteric Ligandnts1_off
3.03Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
2.94Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
2.94Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
2.86Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
2.86Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
2.86Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.78Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.70Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
2.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
2.70Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.70Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
2.63Single5TZRMK86665TZR-FFA1-MK8666
2.63Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
2.63Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
2.63Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
2.63Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
2.63Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
2.63Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
2.56Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
2.56Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
2.56Single4PY02MeSATP4PY0-P2Y12-2MeSATP
2.56Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
2.56Single7SHEPI; PE7SHE-GPR158-PI; PE
2.50Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
2.38Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
2.38Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.33Single7SHEPI; PE7SHE-GPR158-PI; PE
2.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.27Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.27Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.22Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.08Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 7TZF
Class B1
SubFamily Peptide
Type Calcitonin
SubType CT (AMY3)
Species Homo Sapiens
Ligand Amylin
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2; RAMP3
PDB Resolution 2.4
Date 2022-03-23
D.O.I. 10.1126/science.abm9609
Net Summary
Imin 3.21
Number of Linked Nodes 1089
Number of Links 1366
Number of Hubs 233
Number of Links mediated by Hubs 852
Number of Communities 29
Number of Nodes involved in Communities 351
Number of Links involved in Communities 523
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 28649237
Length Of Smallest Path 3
Average Path Length 71.0198
Length of Longest Path 76
Minimum Path Strength 1.34
Average Path Strength 8.60796
Maximum Path Strength 23.01
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 55.6725
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.369
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • biological regulation   • positive regulation of intracellular signal transduction   • regulation of response to stimulus   • calcium-mediated signaling   • regulation of cell communication   • cellular process   • positive regulation of signaling   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • localization   • import into cell   • receptor internalization   • transport   • receptor-mediated endocytosis   • endocytosis   • establishment of localization   • vesicle-mediated transport   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of protein localization to plasma membrane   • protein localization   • regulation of localization   • cellular localization   • regulation of protein localization   • cellular macromolecule localization   • regulation of protein localization to membrane   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • protein localization to plasma membrane   • positive regulation of protein localization to membrane   • regulation of protein localization to cell periphery   • localization within membrane   • protein localization to membrane   • regulation of cellular localization   • macromolecule localization   • positive regulation of protein localization   • regulation of protein localization to plasma membrane   • establishment of protein localization   • nitrogen compound transport   • protein transport   • regulation of signaling receptor activity   • negative regulation of molecular function   • regulation of molecular function   • cross-receptor inhibition within G protein-coupled receptor heterodimer   • G protein-coupled receptor signaling pathway   • negative regulation of signaling receptor activity   • regulation of G protein-coupled receptor signaling pathway   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to endogenous stimulus   • response to chemical   • cellular response to hormone stimulus   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • regulation of receptor recycling   • receptor recycling   • receptor metabolic process   • positive regulation of receptor recycling   • response to oxygen-containing compound   • response to nitrogen compound   • response to amyloid-beta   • heart process   • multicellular organismal process   • system process   • circulatory system process   • G protein-coupled receptor signaling pathway involved in heart process   • intracellular transport   • establishment of localization in cell   • intracellular protein transport   • adrenomedullin receptor signaling pathway   • calcitonin family receptor signaling pathway   • amylin receptor signaling pathway   • response to lipid   • cellular response to oxygen-containing compound   • cellular response to lipid   • response to estradiol   • cellular response to estradiol stimulus   • monoatomic ion transport   • monoatomic cation transport   • calcium ion transport   • metal ion transport   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • amylin receptor 3 signaling pathway   • cell surface   • cellular anatomical structure   • cell periphery   • plasma membrane   • membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • G protein-coupled receptor dimeric complex   • adrenomedullin receptor complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • calcitonin family receptor complex
Gene OntologyCellular Component• cell surface   • cellular anatomical structure   • cell periphery   • plasma membrane   • membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • G protein-coupled receptor dimeric complex   • adrenomedullin receptor complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • calcitonin family receptor complex   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • organelle   • lytic vacuole   • vacuole   • cytoplasm   • intracellular membrane-bounded organelle   • lysosome   • amylin receptor complex   • amylin receptor complex 3   • protein binding   • binding   • signaling receptor binding   • molecular transducer activity   • molecular function activator activity   • signaling receptor activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • hormone activity   • lipid binding   • identical protein binding   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of calcium-mediated signaling   • positive regulation of calcium-mediated signaling   • signal transduction   • positive regulation of cellular process   • regulation of biological process   • regulation of signaling   • biological regulation   • positive regulation of intracellular signal transduction   • regulation of response to stimulus   • calcium-mediated signaling   • regulation of cell communication   • cellular process   • positive regulation of signaling   • behavior   • multicellular organismal process   • eating behavior   • feeding behavior   • amylin receptor 1 signaling pathway   • amylin receptor signaling pathway   • calcitonin family receptor signaling pathway   • G protein-coupled receptor signaling pathway   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • cellular developmental process   • regulation of developmental process   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • multicellular organism development   • cell differentiation   • osteoclast differentiation   • anatomical structure development   • negative regulation of cellular process   • regulation of immune system process   • regulation of multicellular organismal process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • developmental process   • regulation of multicellular organismal development   • negative regulation of leukocyte differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • negative regulation of developmental process   • regulation of myeloid leukocyte differentiation   • negative regulation of myeloid cell differentiation   • negative regulation of osteoclast differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • myeloid cell differentiation   • negative regulation of immune system process   • immune system process   • regulation of hemopoiesis   • negative regulation of multicellular organismal process   • leukocyte differentiation   • monosaccharide metabolic process   • carbohydrate metabolic process   • hexose metabolic process   • small molecule metabolic process   • metabolic process   • primary metabolic process   • glucose metabolic process   • negative regulation of tissue remodeling   • homeostatic process   • negative regulation of bone remodeling   • regulation of bone remodeling   • tissue homeostasis   • regulation of tissue remodeling   • regulation of bone resorption   • bone resorption   • negative regulation of bone resorption   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • amylin receptor 2 signaling pathway   • system process   • sensory perception   • nervous system process   • sensory perception of pain   • positive regulation of cAMP/PKA signal transduction   • cAMP/PKA signal transduction   • regulation of cAMP/PKA signal transduction   • amylin receptor 3 signaling pathway   • intracellular vesicle   • endomembrane system   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • vesicle   • somatodendritic compartment   • cell body   • neuronal cell body   • extracellular region   • extracellular space   • amide binding   • amyloid-beta binding   • peptide binding   • calcitonin family receptor activity   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • calcitonin receptor activity   • amylin receptor activity   • calcitonin gene-related peptide receptor activity   • calcitonin binding   • calcitonin family binding   • peptide hormone binding   • hormone binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • catabolic process   • RNA metabolic process   • macromolecule catabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • post-transcriptional regulation of gene expression   • regulation of RNA metabolic process   • regulation of mRNA catabolic process   • regulation of nucleobase-containing compound metabolic process   • RNA catabolic process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • mRNA catabolic process   • negative regulation of metabolic process   • regulation of macromolecule metabolic process   • regulation of catabolic process   • gene expression   • mRNA metabolic process   • macromolecule biosynthetic process   • nucleic acid metabolic process   • nucleobase-containing compound catabolic process   • regulation of mRNA stability   • regulation of gene expression   • negative regulation of gene expression   • biosynthetic process   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • regulation of RNA stability   • nucleic acid catabolic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • regulation of mRNA metabolic process   • regulation of metabolic process   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction   • phosphatidylinositol 3-kinase/protein kinase B signal transduction   • response to corticosteroid   • response to lipid   • response to hormone   • response to steroid hormone   • response to chemical   • response to endogenous stimulus   • response to glucocorticoid   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • response to amyloid-beta   • cell surface receptor signaling pathway   • calcitonin gene-related peptide receptor signaling pathway   • ossification   • regulation of ossification   • negative regulation of ossification   • cell projection   • cilium   • plasma membrane bounded cell projection   • amylin receptor complex 2   • amylin receptor complex 1   • axon   • neuron projection   • acrosomal vesicle   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception of smell   • cellular response to nitrogen compound   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • cellular response to hormone stimulus   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extrinsic component of plasma membrane   • catalytic complex   • cytoplasmic side of membrane   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • organelle membrane   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNH2
PDB ResiduesL:L:?38
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainE
ProteinRAMP3
UniProtO60896
Sequence
>7TZF_Chain_E
ETGMLERLP LCGKAFADM MGKVDVWKW CNLSEFIVY YESFTNCTE 
MEANVVGCY WPNPLAQGF ITGIHRQFF SNCTVDRVH LEDPPDEVL 
IPLIVIPVV LTVAMAGLV VWRSKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30988
Sequence
>7TZF_Chain_R
YVVGRKKMM DAQYKCYDR MQQLPAYQG EGPYCNRTW DGWLCWDDT 
PAGVLSYQF CPDYFPDFD PSEKVTKYC DEKGVWFKH PENNRTWSN 
YTMCNAFTP EKLKNAYVL YYLAIVGHS LSIFTLVIS LGIFVFFRS 
LGCQRVTLH KNMFLTYIL NSMIIIIHL VEVVPNGEL VRRDPVSCK 
ILHFFHQYM MACNYFWML CEGIYLHTL IVVAVFTEK QRLRWYYLL 
GWGFPLVPT TIHAITRAV YFNDNCWLS VETHLLYII HGPVMAALV 
VNFFFLLNI VRVLVTKMR ETHEAESHM YLKAVKATM ILVPLLGIQ 
FVVFPWRPS NKMLGKIYD YVMHSLIHF QGFFVATIY CFCNNEVQT 
TVKRQWA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7TZF_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKNT 
IVKQMTSGI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVASSS YNNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCSVDT ENIRRVFND CRDIIQRMH 
LRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7TZF_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7TZF_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F2BB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-Gs/β1/γ2; RAMP322023-08-0210.1038/s41589-023-01393-4
8F2B (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-22023-08-0210.1038/s41589-023-01393-4
8F2AB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP32.22023-08-0210.1038/s41589-023-01393-4
8F2A (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-2.22023-08-0210.1038/s41589-023-01393-4
8F0KB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP31.92023-08-0210.1038/s41589-023-01393-4
8F0K (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-1.92023-08-0210.1038/s41589-023-01393-4
7TZF (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-2.42022-03-2310.1126/science.abm9609




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