Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:H127 14.7025427
2R:R:L134 3.395468
3R:R:L150 4.734506
4R:R:R151 5.38438
5R:R:N152 4.1638
6R:R:H155 7.244539
7R:R:I159 3.515467
8R:R:I163 2.5175467
9R:R:R165 9.3475408
10R:R:W169 16.946527
11R:R:V185 4.88403
12R:R:R189 10.7225416
13R:R:Y197 5.58833618
14R:R:H199 7.1325445
15R:R:T201 5.305417
16R:R:F203 9.0125448
17R:R:F204 3.776515
18R:R:W205 9.895419
19R:R:I217 3457
20R:R:W236 7.628519
21R:R:P239 3.33833619
22R:R:W246 7.13429718
23R:R:K250 11.665416
24R:R:D254 6.875415
25R:R:W259 8.19167619
26R:R:D269 5.5775416
27R:R:Y272 7.092517
28R:R:N289 1.8825406
29R:R:L298 4.7625456
30R:R:T306 4.8525455
31R:R:Y327 4.545448
32R:R:L329 3.0225406
33R:R:P334 8.02495
34R:R:F344 8.975496
35R:R:I345 1.6375407
36R:R:Y346 6.3375406
37R:R:S353 3.574528
38R:R:F354 5.11833626
39R:R:F362 5.2975408
40W:W:?1 8.995831240
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F344 R:R:I345 13.55011.26YesYes067
2R:R:F344 R:R:L329 21.4423.65YesYes066
3R:R:L329 R:R:N348 25.26842.75YesNo068
4R:R:N348 R:R:T326 26.5152.92NoNo088
5R:R:T326 R:R:Y327 28.97782.5NoYes088
6R:R:H199 R:R:Y327 33.50636.53YesYes458
7R:R:H199 R:R:R165 52.668814.67YesYes058
8R:R:R165 R:R:Y195 82.42517.2YesNo085
9R:R:V172 R:R:Y195 1003.79NoNo065
10R:R:Q173 R:R:V172 97.31342.87NoNo076
11R:R:Q173 R:R:W169 94.433420.81NoYes277
12R:R:H127 R:R:W169 58.744244.43YesYes277
13R:R:N123 R:R:W169 31.79675.65NoYes277
14R:R:N123 R:R:S353 30.31094.47NoYes278
15R:R:H127 R:R:S353 31.77634.18YesYes278
16R:R:F354 R:R:S353 48.50663.96YesYes268
17R:R:H127 R:R:N166 28.48932.55YesNo077
18R:R:L134 R:R:N166 26.78472.75YesNo087
19R:R:S360 R:R:V361 14.07931.62NoNo085
20R:R:F357 R:R:V361 17.57493.93NoNo055
21R:R:F354 R:R:F357 20.99932.14YesNo265
22R:R:I159 R:R:L134 16.20622.85YesYes678
23R:R:F138 R:R:I159 12.78185.02NoYes067
24R:R:H155 R:R:L366 16.1967.71YesNo395
25R:R:F362 R:R:L366 26.91193.65YesNo085
26R:R:F362 R:R:T316 16.7712.59YesNo087
27R:R:T316 W:W:?1 18.5579.31NoYes070
28R:R:Y327 W:W:?1 32.30042.96YesYes480
29R:R:N202 R:R:R165 42.151310.85NoYes078
30R:R:N202 R:R:T201 39.05772.92NoYes077
31R:R:T201 R:R:W236 10.2586.06YesYes179
32R:R:F198 R:R:T168 23.12623.89NoNo064
33R:R:T168 R:R:Y195 23.91493.75NoNo045
34R:R:Q355 R:R:R165 31.45074.67NoYes098
35R:R:L323 W:W:?1 19.23887.87NoYes080
36R:R:L323 R:R:Q355 31.13013.99NoNo089
37R:R:P239 R:R:T201 28.1283.5YesYes197
38R:R:P239 R:R:V200 42.05975.3YesNo197
39R:R:V200 R:R:Y272 64.35153.79NoYes177
40R:R:W246 R:R:Y272 54.84668.68YesYes187
41R:R:W246 R:R:W259 33.66926.56YesYes189
42R:R:R189 R:R:W259 27.329216.99YesYes169
43R:R:G186 R:R:R189 24.34233NoYes026
44R:R:G186 R:R:V185 22.79041.84NoYes023
45R:R:C188 R:R:V185 11.6423.42NoYes093
46R:R:N283 W:W:?1 37.281824.29NoYes090
47R:R:F207 R:R:N283 36.1983.62NoNo069
48R:R:F207 R:R:V279 27.975411.8NoNo067
49R:R:F204 R:R:V279 28.49953.93YesNo057
50R:R:F204 R:R:V200 23.52312.62YesNo157
51R:R:K250 R:R:W246 16.898217.4YesYes168
52R:R:D254 R:R:K250 13.22449.68YesYes156
53R:R:D254 R:R:E256 10.00869.09YesNo053
54R:R:F207 R:R:I282 12.92423.77NoNo065
55R:R:L287 W:W:?1 50.24172.62NoYes070
56R:R:L287 R:R:L317 48.51682.77NoNo075
57R:R:L317 R:R:V313 46.69522.98NoNo055
58R:R:I290 R:R:V313 41.13881.54NoNo085
59R:R:F286 R:R:I282 11.10772.51NoNo075
60R:R:I217 R:R:I290 35.51114.42YesNo078
61R:R:I217 R:R:I293 21.93564.42YesNo576
62R:R:I293 R:R:L298 20.24632.85NoYes566
63R:R:L298 R:R:T306 14.24214.42YesYes565
64R:R:L319 R:R:L323 13.20419.69NoNo098
65R:R:F350 R:R:F354 10.573412.86NoYes056
66R:R:F362 R:R:L319 12.049112.18YesNo089
67R:R:F198 R:R:Y197 21.64056.19NoYes068
68R:R:P239 R:R:Y197 22.3072.78YesYes198
69R:R:F203 R:R:H199 18.68423.39YesYes485
70R:R:F203 W:W:?1 19.040311.54YesYes480
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F203 R:R:H199 3.39 4 Yes Yes 8 5 1 2
R:R:H199 R:R:M276 3.94 4 Yes No 5 7 2 2
R:R:H199 R:R:Y327 6.53 4 Yes Yes 5 8 2 1
R:R:F203 R:R:M276 14.93 4 Yes No 8 7 1 2
R:R:F203 R:R:Y327 6.19 4 Yes Yes 8 8 1 1
R:R:F203 W:W:?1 11.54 4 Yes Yes 8 0 1 0
R:R:M206 W:W:?1 18.76 0 No Yes 9 0 1 0
R:R:F207 R:R:N283 3.62 0 No No 6 9 2 1
R:R:F284 R:R:L280 4.87 4 No No 4 6 1 1
R:R:L280 W:W:?1 11.37 4 No Yes 6 0 1 0
R:R:N283 W:W:?1 24.29 0 No Yes 9 0 1 0
R:R:F284 W:W:?1 4.62 4 No Yes 4 0 1 0
R:R:L287 R:R:L317 2.77 0 No No 7 5 1 2
R:R:L287 W:W:?1 2.62 0 No Yes 7 0 1 0
R:R:F362 R:R:T316 2.59 0 Yes No 8 7 2 1
R:R:T316 W:W:?1 9.31 0 No Yes 7 0 1 0
R:R:L319 R:R:L323 9.69 0 No No 9 8 2 1
R:R:F362 R:R:L319 12.18 0 Yes No 8 9 2 2
R:R:L320 R:R:P321 3.28 0 No No 7 7 1 2
R:R:L320 W:W:?1 11.37 0 No Yes 7 0 1 0
R:R:L323 R:R:Q355 3.99 0 No No 8 9 1 2
R:R:L323 W:W:?1 7.87 0 No Yes 8 0 1 0
R:R:Y327 W:W:?1 2.96 4 Yes Yes 8 0 1 0
R:R:T326 R:R:Y327 2.5 0 No Yes 8 8 2 1
R:R:G210 W:W:?1 2.16 0 No Yes 7 0 1 0
R:R:G324 W:W:?1 1.08 0 No Yes 9 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
91.67Single4Z9GCP-3763954Z9G-CRF1-CP-376395
91.67Single8GTIBMK-C2058GTI-CRF1-BMK-C205
75.00Single4K5YCP-3763954K5Y-CRF1-CP-376395
73.33Single8GTMBMK-C2038GTM-CRF1-BMK-C203
41.18Consensusffa3_on_alloOther Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
38.89Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
31.25Single8HNNSCH5467388HNN-CXCR3-SCH546738
20.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
19.35Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
19.35Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
19.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
19.05Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
16.67Single6KK1PubChem 681786306KK1-GLP-1-PubChem 68178630
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7VODCariprazine7VOD-5-HT2A-Cariprazine
15.62Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
15.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.00Single7RBTPubChem 1631837747RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
15.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
13.51Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
13.04Single6A93Risperidone6A93-5-HT2A-Risperidone
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
12.50Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
12.50Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
12.50Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
12.50Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
12.50Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
12.12Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
12.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
12.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
11.90Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
11.43Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
11.43Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
11.11Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
11.11Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
11.11Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
10.53Single7C7QPubChem 70238487C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
10.53Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.53Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
10.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.53Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
10.53Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
10.53Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
10.53Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
10.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
10.53Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
10.00Single6A94Zotepine6A94-5-HT2A-Zotepine
10.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.00Single7EJX(1R;2R)-2-PCCA7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
10.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
10.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
10.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
9.52Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.52Single6FFHFenobam6FFH-mGlu5-Fenobam
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.52Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.52Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
9.52Single8JPFPubChem 1186104278JPF-NTS1-Neurotensin-PubChem 118610427
9.52Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
9.52Single8X63Mepyramine8X63-H1-Mepyramine
9.52Single8X64Desloratadine8X64-H1-Desloratadine
9.09Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.09Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.09Single7SINNPS-21437SIN-CaS-NPS-2143
9.09Single7SINNPS-21437SIN-CaS-NPS-2143
9.09Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
9.09Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09Single8EA0Iperoxo8EA0-M3-Iperoxo
9.09Single8FN0PubChem 1186104278FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8GW8KHF8GW8-PTH1-KHF-Gs/&β;1/&γ;2
9.09Single8JPCPubChem 118610427; GDP; Mg8JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
9.09Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
9.09Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Single5V54Methiothepin5V54-5-HT1B-Methiothepin
8.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
8.70Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
8.70Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
8.70Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
8.70Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
8.70Single7P2L4YI7P2L-mGlu5-4YI
8.70Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70Consensus5ht1_offOrthosteric Ligand5ht1b_off
8.70Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
8.70Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
8.70Consensushistamine_offOrthosteric Ligandh1_off
8.57Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.33Single6CM4Risperidone6CM4-D2-Risperidone
8.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single7DFPSpiperone7DFP-D2-Spiperone
8.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
8.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
8.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
8.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.33Consensusgi_class-fOther Ligandgi_frizzled
8.33Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
8.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
8.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
8.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.00Single5CGDHTL142425CGD-mGlu5-HTL14242
8.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
8.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
8.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
8.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
8.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
7.69Single8X5YAstemizole8X5Y-H1-Astemizole
7.69Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
7.41Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
7.14Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
7.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
6.90Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
6.90Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
6.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
6.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
6.67Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
6.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
6.25Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.06Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
6.06Consensusgo_class-b1Orthosteric Ligandgo_crf
6.06Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.88Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
5.88Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.88Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
5.88Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.88Consensussensory_onOrthosteric Ligandopsin_on
5.71Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
5.71Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
5.56Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.56Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.56Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
5.56Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
5.56Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.56Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
5.56Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
5.56Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
5.56Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
5.56Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
5.56Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.26Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
5.26Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
5.26Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
5.26Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
5.26Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
5.26Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
5.26Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.26Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.26Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.26Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.26Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.26Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.26Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
5.26Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
5.26Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
5.26Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
5.26Consensusgo_class-b2Orthosteric Ligandgo_adhesion
5.26Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
5.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
5.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
5.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
5.00Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
5.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
5.00Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
5.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
5.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
5.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.00Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
5.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
5.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
5.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
5.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.00Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
5.00Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
5.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
5.00Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
5.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Consensusgt_class-aOrthosteric Ligandgt_opsin
5.00Consensusgt_opsinOrthosteric Ligandgt_sensory
5.00Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
5.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
5.00Consensusmglu_onOther Ligandmglu2_on mglu4_on
5.00Consensusnts1_on_alloOther Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single2YDOAdenosine2YDO-A2A-Adenosine
4.76Single3RZECidoxepin3RZE-H1-Cidoxepin
4.76Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
4.76Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
4.76Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
4.76Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
4.76Single5IU7Q274563465IU7-A2A-Q27456346-Na
4.76Single5JTBZM2413855JTB-A2A-ZM241385
4.76Single5K2BZM2413855K2B-A2A-ZM241385-Na
4.76Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
4.76Single5UVIZM2413855UVI-A2A-ZM241385
4.76Single6AQFZM2413856AQF-A2A-ZM241385
4.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
4.76Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
4.76Single6MH8ZM2413856MH8-A2A-ZM241385
4.76Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
4.76Single6TPKRetosiban6TPK-OT-Retosiban
4.76Single6TPNHTL66416TPN-OX2-HTL6641
4.76Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
4.76Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
4.76Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
4.76Single6ZG9GSK10347026ZG9-M1-GSK1034702
4.76Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
4.76Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
4.76Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
4.76Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.76Single7T32ZM2413857T32-A2A-ZM241385
4.76Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
4.76Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
4.76Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
4.76Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.76Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
4.76Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
4.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
4.76Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
4.76Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
4.76Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
4.76Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
4.76Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
4.76Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
4.76Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
4.76Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
4.76Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
4.76Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.76Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
4.76Consensussensory_offOrthosteric Ligandopsin_off
4.76Consensusvasopressin-ot_offOrthosteric Ligandot_off
4.65Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
4.55Single3EMLZM2413853EML-A2A-ZM241385
4.55Single3NY8ICI 118-5513NY8-β2-ICI 118-551
4.55Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
4.55Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.55Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.55Single4DAJTiotropium4DAJ-M3-Tiotropium
4.55Single4EIYZM2413854EIY-A2A-ZM241385-Na
4.55Single4EJ4Naltrindole4EJ4-δ-Naltrindole
4.55Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
4.55Single4MQSIperoxo4MQS-M2-Iperoxo
4.55Single4U14Tiotropium4U14-M3-Tiotropium
4.55Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
4.55Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
4.55Single5DSGTiotropium5DSG-M4-Tiotropium
4.55Single5IU8Q274563475IU8-A2A-Q27456347-Na
4.55Single5K2AZM2413855K2A-A2A-ZM241385-Na
4.55Single5OLGZM2413855OLG-A2A-ZM241385-Na
4.55Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
4.55Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
4.55Single5TGZAM65385TGZ-CB1-AM6538
4.55Single5VRAZM2413855VRA-A2A-ZM241385-Na
4.55Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
4.55Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
4.55Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
4.55Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
4.55Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
4.55Single6IIVDaltroban6IIV-TP-Daltroban
4.55Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
4.55Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
4.55Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
4.55Single6S0LZM2413856S0L-A2A-ZM241385
4.55Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
4.55Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
4.55Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
4.55Single7PYRPSB-21157PYR-A2A-PSB-2115
4.55Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
4.55Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
4.55Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
4.55Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.55Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.55Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
4.55Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
4.55Single8CU6LJ-45178CU6-A2A-LJ-4517
4.55Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
4.55Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
4.55Single8JJOAlprenolol8JJO-β2-Alprenolol
4.55Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
4.55Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
4.55Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
4.55Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
4.55Consensusa2_offOrthosteric Liganda2a_off
4.55Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
4.55Consensusadenosine_onOrthosteric Liganda1_on a2_on
4.55Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
4.55Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.55Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
4.55Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.55Consensusblt_onOrthosteric Ligandblt1_on
4.55Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
4.55Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
4.55Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
4.55Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
4.55Consensushistamine_onOrthosteric Ligandh1_on h4_on
4.55Consensusleuko_onOrthosteric Ligandblt_on
4.55Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.55Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
4.55Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
4.55Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.55Consensusnucleotide_onOrthosteric Ligandadenosine_on
4.55Consensustachykinin_offOrthosteric Ligandnk1_off
4.55Consensustar_onOrthosteric Ligandta1_on
4.55Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
4.35Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
4.35Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
4.35Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
4.35Single5CGCHTL142425CGC-mGlu5-HTL14242
4.35Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
4.35Single5IUAQ274563485IUA-A2A-Q27456348-Na
4.35Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
4.35Single5N2SPSB365N2S-A1-PSB36
4.35Single5NM2ZM2413855NM2-A2A-ZM241385-Na
4.35Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
4.35Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
4.35Single5XPRBosentan5XPR-ETB-Bosentan
4.35Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
4.35Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
4.35Single6LFLPubChem 1534669966LFL-CXCR2-PubChem 153466996
4.35Single6LPLZM2413856LPL-A2A-ZM241385-Na
4.35Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.35Single6PS6Timolol6PS6-β2-Timolol
4.35Single6S0QZM2413856S0Q-A2A-ZM241385
4.35Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.35Single6WQAZM2413856WQA-A2A-ZM241385-Na
4.35Single7C4SS1P7C4S-S1P3-S1P
4.35Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
4.35Single7RM5ZM2413857RM5-A2A-ZM241385-Na
4.35Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.35Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
4.35Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
4.35Single8FYNZM2413858FYN-A2A-ZM241385-Na
4.35Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.35Single8GNEKW-63568GNE-A2A-KW-6356-Na
4.35Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
4.35Single8QOTNanobody E8QOT-μ-Nanobody E
4.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.35Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
4.35Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
4.35Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
4.35Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
4.35Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.35Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
4.35Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
4.35Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.35Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
4.35Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
4.35Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
4.35Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single2YDVNECA2YDV-A2A-NECA
4.17Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
4.17Single4DJHJDTic4DJH-κ-JDTic
4.17Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
4.17Single4U15Tiotropium4U15-M3-Tiotropium
4.17Single4UHRCGS216804UHR-A2A-CGS21680
4.17Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
4.17Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
4.17Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
4.17Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
4.17Single5G53NECA5G53-A2A-NECA-Gs
4.17Single5X93K-87945X93-ETB-K-8794
4.17Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
4.17Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.17Single6E59L-7607356E59-NK1-L-760735
4.17Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
4.17Single6J20Aprepitant6J20-NK1-Aprepitant
4.17Single6J21Aprepitant6J21-NK1-Aprepitant
4.17Single6OL9Tiotropium6OL9-M5-Tiotropium
4.17Single6TQ7SB-3348676TQ7-OX1-SB-334867
4.17Single7EPENAM5637EPE-mGlu-NAM563
4.17Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
4.17Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
4.17Single7PX4PSB-21137PX4-A2A-PSB-2113
4.17Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
4.17Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
4.17Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
4.17Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
4.17Single7W41PD1762527W41-BB2-PD176252
4.17Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
4.17Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
4.17Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
4.17Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
4.17Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
4.17Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
4.17Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
4.17Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
4.17Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
4.17Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
4.17Single8JPBPubChem 118610427; GDP; Mg8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
4.17Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.17Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
4.17Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.17Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
4.17Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
4.17Consensusa2_onOrthosteric Liganda2a_on a2b_on
4.17Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusadenosine_offOrthosteric Liganda1_off a2_off
4.17Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
4.17Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
4.17Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
4.17Consensusbombesin_offOrthosteric Ligandbb2_off
4.17Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
4.17Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
4.17Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
4.17Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
4.17Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
4.17Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
4.17Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
4.17Consensuslpa_offOrthosteric Ligandlpa1_off
4.17Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
4.17Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
4.17Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
4.17Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
4.17Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
4.17Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.17Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
4.00Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
4.00Single4AMIBucindolol4AMI-β1-Bucindolol
4.00Single4N4WSANT-14N4W-SMO-SANT-1
4.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
4.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
4.00Single5CXVTiotropium5CXV-M1-Tiotropium
4.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
4.00Single5LWEVercirnon5LWE-CCR9-Vercirnon
4.00Single5X33BIIL2605X33-BLT1-BIIL260
4.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
4.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
4.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.00Single6HLPNetupitant6HLP-NK1-Netupitant
4.00Single6IIURamatroban6IIU-TP-Ramatroban
4.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
4.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
4.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
4.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
4.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
4.00Single7K15MKD0467K15-BLT1-MKD046-Na
4.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
4.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
4.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7YITNalfurafine7YIT-κ-Nalfurafine
4.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
4.00Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
4.00Single8JWZAB9288JWZ-A2A-AB928-Na
4.00Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
4.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
4.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
4.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
4.00Consensusblt_offOrthosteric Ligandblt1_off
4.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
4.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
4.00Consensusccr9_off_alloOther Ligand5LWE-CCR9-Vercirnon
4.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
4.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
4.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
4.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
4.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
4.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
4.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
4.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
4.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
3.85Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
3.85Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
3.85Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
3.85Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
3.85Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
3.85Single6K1QIRL25006K1Q-ETB-IRL2500
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.85Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
3.85Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
3.85Single7EZCUKA7EZC-A2A-UKA
3.85Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
3.85Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
3.85Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
3.85Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
3.85Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
3.85Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
3.85Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
3.85Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
3.85Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.85Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
3.85Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.85Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.85Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
3.85Consensusendothelin_offOrthosteric Ligandetb_off
3.85Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
3.85Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
3.70Single3NY9PubChem 9131033NY9-β2-PubChem 913103
3.70Single4UG2CGS216804UG2-A2A-CGS21680
3.70Single5EE7MK08935EE7-Glucagon-MK0893
3.70Single5WF6UK-4320975WF6-A2A-UK-432097
3.70Single5ZTYAM102575ZTY-CB2-AM10257
3.70Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.70Single6PT3DPI-2876PT3-δ-DPI-287
3.70Single7SK9CCX6627SK9-ACKR3-CCX662
3.70Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
3.70Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
3.70Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Consensusgs_class-b2Orthosteric Ligandgs_adgr
3.70Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
3.70Consensuslpl_offOrthosteric Ligands1p_off lpa_off
3.57Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
3.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.57Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
3.57Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
3.57Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
3.57Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
3.57Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
3.57Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
3.45Single3QAKUK-4320973QAK-A2A-UK-432097
3.45Single6HLOAprepitant6HLO-NK1-Aprepitant
3.45Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.45Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
3.33Single5WF5UK-4320975WF5-A2A-UK-432097
3.33Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
3.33Single6PT2KGCHM076PT2-δ-KGCHM07
3.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
3.33Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.23Single6JODAngiotensin II6JOD-AT2-Angiotensin II
3.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
3.23Single7C61Ergotamine7C61-5-HT1B-Ergotamine
3.23Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
3.23Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
3.12Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.12Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
3.12Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
3.12Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.12Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.12Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.12Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
3.12Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.03Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.03Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
3.03Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
3.03Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
3.03Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
3.03Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
3.03Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.03Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.03Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
3.03Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.94Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
2.94Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
2.94Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
2.94Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
2.94Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.94Consensusendothelin_onOrthosteric Ligandetb_on eta_on
2.94Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
2.94Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
2.86Single6IGLIRL16206IGL-ETB-IRL1620
2.86Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.86Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
2.86Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
2.86Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
2.86Single8IY6Endothelin-18IY6-ETB-Endothelin-1
2.86Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
2.86Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
2.86Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.86Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
2.86Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
2.78Single5GLHEndothelin-15GLH-ETB-Endothelin-1
2.78Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
2.78Single6IGKEndothelin-36IGK-ETB-Endothelin-3
2.78Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.78Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.78Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
2.78Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
2.78Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
2.78Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
2.70Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
2.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
2.70Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
2.70Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
2.70Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
2.70Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
2.63Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
2.63Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.63Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
2.63Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
2.63Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
2.56Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
2.56Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
2.56Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.50Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
2.44Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.38Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.38Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.33Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.22Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf

PDB Summary
PDB 8GTG
Class B1
SubFamily Peptide
Type Corticotropin Releasing Factor
SubType CRF1
Species Homo sapiens
Ligand -
Other Ligand(s) BMK-I152
Protein Partners -
PDB Resolution 2.75
Date 2023-09-13 
D.O.I. 10.1038/s12276-023-01082-1
Net Summary
Imin 2.55
Number of Linked Nodes 237
Number of Links 266
Number of Hubs 40
Number of Links mediated by Hubs 153
Number of Communities 9
Number of Nodes involved in Communities 65
Number of Links involved in Communities 89
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 39273
Length Of Smallest Path 3
Average Path Length 14.4218
Length of Longest Path 29
Minimum Path Strength 1.245
Average Path Strength 6.75423
Maximum Path Strength 32.62
Minimum Path Correlation 0.7
Average Path Correlation 0.929817
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 44.2736
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.6138
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeCW9
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeCW9
Name8-(4-bromanyl-2,6-dimethoxy-phenyl)-~{N},~{N}-bis(2-methoxyethyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-amine
Synonyms
Identifier8-(4-bromanyl-2,6-dimethoxy-phenyl)-~{N},~{N}-bis(2-methoxyethyl)-2,7-dimethyl-pyrazolo[1,5-a][1,3,5]triazin-4-amine
FormulaC21 H28 Br N5 O4
Molecular Weight494.382
SMILESCc1c(c2nc(nc(n2n1)N(CCOC)CCOC)C)c3c(cc(cc3OC)Br)OC
PubChem44517108
Formal Charge0
Total Atoms59
Total Chiral Atoms0
Total Bonds61
Total Aromatic Bonds16

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP34998-2
Sequence
>8GTG_Chain_R
MEILNEEKK SKVHYHVAA IINYLGHCI SLVALLVAF VLFLRARSI 
RCLRNIIHA NLIAAFILR NATWFVVQL TMSPEVHQS NVGWCRLVT 
AAYNYFHVT NFFWMFGEG CYLHTAIVL TDRLRAWMF ICIGWGVPF 
PIIVAWAIG KLYYDNEKC WAGKRPGVY TDYIYQGPM ALVLLINFI 
FLFNIVRIL MTKLRASTT SETIQARKA VKATLVLLP LLGITYMLA 
FVNPGEDEV SRVVFIYFN AFLESFQGF FVSVFACFL NS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4K5YB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-CP-376395-2.982013-07-1710.1038/nature12357
4Z9GB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-CP-376395-3.182016-06-2910.2174/1874467210666170110114727
6P9XB1PeptideCorticotropin Releasing FactorCRF1Homo sapiensCorticoliberin-Gs/&β;1/&γ;22.912020-02-0510.1016/j.molcel.2020.01.012
6PB0B1PeptideCorticotropin Releasing FactorCRF1Homo sapiensUrocortin-chim(NtGi1-Gs)/&β;1/&γ;232020-02-1210.1016/j.molcel.2020.01.013
8GTIB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-BMK-C205-2.22023-09-1310.1038/s12276-023-01082-1
8GTMB1PeptideCorticotropin Releasing FactorCRF1Homo sapiens-BMK-C203-2.62023-09-1310.1038/s12276-023-01082-1




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