Show 91.67 Single 4Z9G CP-376395 4Z9G-CRF1 -CP-376395 Show 91.67 Single 8GTI BMK-C205 8GTI-CRF1 -BMK-C205 Show 75.00 Single 4K5Y CP-376395 4K5Y-CRF1 -CP-376395 Show 73.33 Single 8GTM BMK-C203 8GTM-CRF1 -BMK-C203 Show 41.18 Consensus ffa3_on_allo Other Ligand 8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2 Show 38.89 Single 8J20 AR420626 8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2 Show 31.25 Single 8HNN SCH546738 8HNN-CXCR3-SCH546738 Show 20.00 Single 7VOE Aripiprazole 7VOE-5-HT2A -Aripiprazole Show 19.35 Single 7TYL Amylin 7TYL-CT-Amylin-Gs/&β;1/&γ;2 Show 19.35 Single 7TYX Amylin 7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2 Show 19.05 Single 8JD5 BQI; HZE; PEF 8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2 Show 19.05 Single 8TAO CDPPB 8TAO-mGlu5; mGlu5-Quisqualate-CDPPB Show 16.67 Single 6KK1 PubChem 68178630 6KK1-GLP-1-PubChem 68178630 Show 16.67 Single 6XBJ Cholesterol 6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2 Show 15.79 Single 7VOD Cariprazine 7VOD-5-HT2A -Cariprazine Show 15.62 Single 7TYF Amylin 7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1 Show 15.00 Single 6FKD PubChem 137349183 6FKD-Rhodopsin-PubChem 137349183 Show 15.00 Single 7RBT PubChem 163183774 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 Show 15.00 Single 7WC8 Lumateperone 7WC8-5-HT2A -Lumateperone Show 15.00 Single 8JT8 (R)-IHCH-7179 8JT8-5-HT2A -(R)-IHCH-7179 Show 13.51 Single 8F2A Pramlintide analogue san385 8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 Show 13.04 Single 6A93 Risperidone 6A93-5-HT2A -Risperidone Show 13.04 Single 8T6J CDPPB 8T6J-mGlu5; mGlu5-CDPPB Show 13.04 Single 8TB7 PubChem 168510218 8TB7-GPR61-PubChem 168510218 Show 12.50 Single 7MTS ADX55164 7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 Show 12.50 Single 7TYW Calcitonin-1 7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1 Show 12.50 Single 8F2B Pramlintide analogue san45 8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3 Show 12.50 Single 8JD3 HZR; PEF 8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2 Show 12.50 Consensus gs_ct Orthosteric Ligand 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 Show 12.12 Single 7TYI Amylin 7TYI-CT-Amylin-Gs/&β;1/&γ;2 Show 12.12 Single 7TYN Calcitonin-1 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 Show 12.00 Single 7MTR ADX55164 7MTR-mGlu2; mGlu2-Glutamate-ADX55164 Show 11.90 Single 8F0J Pramlintide analogue san45 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 Show 11.43 Single 7TZF Amylin 7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3 Show 11.43 Single 8F0K Pramlintide analogue san385 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3 Show 11.11 Single 7CA3 rac-BHFF 7CA3-GABAB1 , GABAB2 -rac-BHFF Show 11.11 Single 7V68 Iperoxo 7V68-M4 -Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 Show 11.11 Single 8X2K 5YM 8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2 Show 11.11 Single 9AUC Calcitonin gene-related peptide-1 9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 Show 10.53 Single 7C7Q PubChem 7023848 7C7Q-GABAB1 , GABAB2 -Baclofen-PubChem 7023848 Show 10.53 Single 7M3E Ca; Ca; Tryptophan; NPS-2143; PO4 7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4 Show 10.53 Single 7M3E Ca; Ca; Tryptophan; NPS-2143; PO4 7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4 Show 10.53 Single 7SIL Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 Show 10.53 Single 7SIL Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 Show 10.53 Single 8A6C All-trans-retinal 8A6C-Rhodopsin-All-trans-retinal Show 10.53 Single 8A6D All-trans-retinal 8A6D-Rhodopsin-All-trans-retinal Show 10.53 Single 8A6E All-trans-retinal 8A6E-Rhodopsin-All-trans-retinal Show 10.53 Single 8SZG Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2 Show 10.53 Single 8WPG Tryptophan; Cinacalcet; PO4; Ca 8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca Show 10.00 Single 3OAX 11-cis-Retinal 3OAX-Rhodopsin-11-cis-Retinal Show 10.00 Single 6A94 Zotepine 6A94-5-HT2A -Zotepine Show 10.00 Single 6FFI MMPEP 6FFI-mGlu5 -MMPEP Show 10.00 Single 6FKA PubChem 132473037 6FKA-Rhodopsin-PubChem 132473037 Show 10.00 Single 7EJX (1R;2R)-2-PCCA 7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2 Show 10.00 Single 7TYO Calcitonin 7TYO-CT-Calcitonin-Gs/&β;1/&γ;2 Show 10.00 Single 7VVO PTH 7VVO-PTH1-PTH-Gs/&β;1/&γ;2 Show 10.00 Single 7ZBC 11-cis-Retinal 7ZBC-Rhodopsin-11-cis-Retinal Show 10.00 Consensus 5ht2a_off Orthosteric Ligand 6A94-5-HT2A -Zotepine 6WH4-5-HT2A -Methiothepin 7VOE-5-HT2A -Aripiprazole 7VOD-5-HT2A -Cariprazine 7WC8-5-HT2A -Lumateperone 6A93-5-HT2A -Risperidone Show 9.52 Single 1HZX 11-cis-Retinal 1HZX-Rhodopsin-11-cis-Retinal Show 9.52 Single 6FFH Fenobam 6FFH-mGlu5 -Fenobam Show 9.52 Single 7E9G JNJ-40411813 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2 Show 9.52 Single 7F83 PF-05190457 7F83-Ghrelin-PF-05190457 Show 9.52 Single 7M3J NPS-2143; PO4 7M3J-CaS-NPS-2143; PO4 Show 9.52 Single 8J18 (3R)-3-hydroxydodecanoic acid 8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2 Show 9.52 Single 8JPF PubChem 118610427 8JPF-NTS1 -Neurotensin-PubChem 118610427 Show 9.52 Single 8JR9 PCO371 8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2 Show 9.52 Single 8SZH Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2 Show 9.52 Single 8X63 Mepyramine 8X63-H1 -Mepyramine Show 9.52 Single 8X64 Desloratadine 8X64-H1 -Desloratadine Show 9.09 Single 6LUQ Haloperidol 6LUQ-D2 -Haloperidol Show 9.09 Single 7M3J NPS-2143; PO4 7M3J-CaS-NPS-2143; PO4 Show 9.09 Single 7SIN NPS-2143 7SIN-CaS-NPS-2143 Show 9.09 Single 7SIN NPS-2143 7SIN-CaS-NPS-2143 Show 9.09 Single 7TRK Iperoxo 7TRK-M4 -Iperoxo-Gi1/&β;1/&γ;2 Show 9.09 Single 8E9Z Iperoxo 8E9Z-M3 -Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 9.09 Single 8EA0 Iperoxo 8EA0-M3 -Iperoxo Show 9.09 Single 8FN0 PubChem 118610427 8FN0-NTS1 -Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2 Show 9.09 Single 8GW8 KHF 8GW8-PTH1-KHF-Gs/&β;1/&γ;2 Show 9.09 Single 8JPC PubChem 118610427; GDP; Mg 8JPC-NTS1 -Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 Show 9.09 Single 9AYF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2 Show 9.09 Consensus gq_muscarinic Orthosteric Ligand 6OIJ-M1 -Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 Show 9.09 Consensus m1_on Orthosteric Ligand 6OIJ-M1 -Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 Show 8.70 Single 5V54 Methiothepin 5V54-5-HT1B -Methiothepin Show 8.70 Single 6O3C Cholesterol 6O3C-SMO-SAG21k-Cholesterol Show 8.70 Single 6OIJ Iperoxo 6OIJ-M1 -Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2 Show 8.70 Single 6W2X PubChem 23727970 6W2X-GABAB1 , GABAB2 -PubChem 5311042-PubChem 23727970 Show 8.70 Single 7EW4 CYM5541 7EW4-S1P3 -CYM5541-Gi1/&β;1/&γ;2 Show 8.70 Single 7EW7 PubChem 4077460 7EW7-S1P1 -PubChem 4077460-Gi1/&β;1/&γ;2 Show 8.70 Single 7P2L 4YI 7P2L-mGlu5 -4YI Show 8.70 Single 7TRQ Iperoxo 7TRQ-M4 -Iperoxo-VU0467154-Gi1/&β;1/&γ;2 Show 8.70 Single 8T6J CDPPB 8T6J-mGlu5; mGlu5-CDPPB Show 8.70 Single 8WPU Tryptophan; Cinacalcet; PO4; Ca 8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 8.70 Consensus 5ht1_off Orthosteric Ligand 5ht1b_off Show 8.70 Consensus 5ht1b_off Orthosteric Ligand 5V54-5-HT1B -Methiothepin Show 8.70 Consensus h1_off Orthosteric Ligand 3RZE-H1 -Cidoxepin 8X5Y-H1 -Astemizole 8X63-H1 -Mepyramine 8X64-H1 -Desloratadine Show 8.70 Consensus histamine_off Orthosteric Ligand h1_off Show 8.57 Single 7TYH Calcitonin-1 7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2 Show 8.33 Single 6CM4 Risperidone 6CM4-D2 -Risperidone Show 8.33 Single 6XBL Cholesterol 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 8.33 Single 7DFP Spiperone 7DFP-D2 -Spiperone Show 8.33 Single 7EVY Siponimod 7EVY-S1P1 -Siponimod-Gi1/&β;1/&γ;2 Show 8.33 Single 7WCM MBX-2982 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2 Show 8.33 Single 7WCN AR231453 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 Show 8.33 Single 7XZ5 Lysophosphatidylcholine 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 Show 8.33 Single 8JD5 BQI; HZE; PEF 8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2 Show 8.33 Consensus gi_class-f Other Ligand gi_frizzled Show 8.33 Consensus gi_frizzled Other Ligand 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 8.33 Consensus gpr119_on Orthosteric Ligand 7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2 Show 8.33 Consensus s1p_on Orthosteric Ligand s1p3_on s1p5_on s1p1_on s1p2_on Show 8.11 Single 7TYY Calcitonin-1 7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2 Show 8.00 Single 4OR2 FITM 4OR2-mGlu1; mGlu1-FITM Show 8.00 Single 5CGD HTL14242 5CGD-mGlu5 -HTL14242 Show 8.00 Single 6BQH Ritanserin 6BQH-5-HT2C -Ritanserin Show 8.00 Single 7EVZ Cenerimod 7EVZ-S1P1 -Cenerimod-Gi1/&β;1/&γ;2 Show 8.00 Single 7SK7 CCX662 7SK7-ACKR3-CXCL12-CCX662 Show 8.00 Single 7XZ6 APD668 7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 Show 8.00 Single 8JD3 HZR; PEF 8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2 Show 8.00 Consensus 5ht2c_off Orthosteric Ligand 6BQH-5-HT2C -Ritanserin Show 7.69 Single 8SZG Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2 Show 7.69 Single 8X5Y Astemizole 8X5Y-H1 -Astemizole Show 7.69 Consensus fpr1-alx_on Orthosteric Ligand 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 Show 7.41 Single 7TD4 Siponimod 7TD4-S1P1 -Siponimod-Gi1/&β;1/&γ;2 Show 7.14 Single 7CUM Phospholipid 7CUM-GABAB1 , GABAB2 -CGP54626-Phospholipid Show 7.14 Single 8SZH Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2 Show 6.90 Single 7T6T fMLFII 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 Show 6.90 Consensus gi_formylpeptide Orthosteric Ligand 7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 Show 6.67 Single 4A4M All-trans-retinal 4A4M-Rhodopsin-All-trans-retinal-Gt(CT) Show 6.67 Single 5EN0 All-trans-retinal 5EN0-Rhodopsin-All-trans-retinal-Gt(CT) Show 6.67 Single 7WUI IP15 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 6.67 Single 8H4K GW9508 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 6.25 Single 3PXO All-trans-retinal 3PXO-Rhodopsin-All-trans-retinal Show 6.25 Single 5DYS All-trans-retinal 5DYS-Rhodopsin-All-trans-retinal Show 6.25 Single 8SZI Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2 Show 6.06 Single 7WVY Amyloid-Beta42 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 Show 6.06 Consensus go_class-b1 Orthosteric Ligand go_crf Show 6.06 Consensus go_crf Orthosteric Ligand 7TS0-CRF2 -Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 Show 5.88 Single 2HPY All-trans-retinal 2HPY-Rhodopsin-All-trans-retinal Show 5.88 Single 6OY9 All-trans-retinal 6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 5.88 Single 6PB1 Urocortin 6PB1-CRF2 -Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.88 Single 6UUS Adrenomedullin 6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3 Show 5.88 Single 7DD5 Ca; Ca; Tryptophan; NPS-2143 7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143 Show 5.88 Single 8WC5 Tetramethylammonium ion 8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.88 Consensus calcitonin_on Orthosteric Ligand ct_on ctlike_on Show 5.88 Consensus sensory_on Orthosteric Ligand opsin_on Show 5.71 Single 6PB0 Urocortin 6PB0-CRF1 -Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.71 Single 7TS0 Urocortin 7TS0-CRF2 -Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2 Show 5.56 Single 2J4Y 11-cis-Retinal 2J4Y-Rhodopsin-11-cis-Retinal Show 5.56 Single 2ZIY 11-cis-Retinal 2ZIY-Rhodopsin-11-cis-Retinal Show 5.56 Single 3C9M 11-cis-Retinal 3C9M-Rhodopsin-11-cis-Retinal Show 5.56 Single 3PQR All-trans-retinal 3PQR-Rhodopsin-All-trans-retinal-Gt(CT) Show 5.56 Single 5WKT Octyl Beta-D-Glucopyranoside 5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT) Show 5.56 Single 7D77 Hydrocortisone 7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 Show 5.56 Single 7MT8 All-trans-retinal 7MT8-Rhodopsin-All-trans-retinal-GRK1 Show 5.56 Single 7MT9 All-trans-retinal 7MT9-Rhodopsin-All-trans-retinal-GRK1 Show 5.56 Single 7MTA All-trans-retinal 7MTA-Rhodopsin-All-trans-retinal-GRK1 Show 5.56 Single 8IU2 Retinal 8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2 Show 5.56 Single 8POK Histamine 8POK-H2 -Histamine-Gs/&β;1/&γ;2 Show 5.56 Consensus opsin_on Orthosteric Ligand 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 5.26 Single 1L9H 11-cis-Retinal 1L9H-Rhodopsin-11-cis-Retinal Show 5.26 Single 1U19 11-cis-Retinal 1U19-Rhodopsin-11-cis-Retinal Show 5.26 Single 2G87 All-trans-retinal 2G87-Rhodopsin-All-trans-retinal Show 5.26 Single 2I35 11-cis-Retinal 2I35-Rhodopsin-11-cis-Retinal Show 5.26 Single 3AYM All-trans-retinal 3AYM-Rhodopsin-All-trans-retinal Show 5.26 Single 3V2W PubChem 51892645 3V2W-S1P1 -PubChem 51892645 Show 5.26 Single 5TE5 20-Methanoretinal 5TE5-Rhodopsin-20-Methanoretinal Show 5.26 Single 6FK6 PubChem 132473033 6FK6-Rhodopsin-PubChem 132473033 Show 5.26 Single 6I9K 9-cis-Retinal 6I9K-Rhodopsin-9-cis-Retinal Show 5.26 Single 6PH7 Nerol 6PH7-Rhodopsin-Nerol-Gt(CT) Show 5.26 Single 7D76 Beclomethasone 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2 Show 5.26 Single 7DD5 Ca; Ca; Tryptophan; NPS-2143 7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143 Show 5.26 Single 7YFC Histamine 7YFC-H4 -Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 5.26 Single 7YFD Imetit 7YFD-H4 -Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 5.26 Single 8HN8 Histamine 8HN8-H4 -Histamine-Gi1/&β;1/&γ;2 Show 5.26 Single 8ITF DMCHA 8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.26 Single 8SZF Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW Show 5.26 Single 8W89 PEA 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 5.26 Single 8W8B SEP-363856 8W8B-5-HT1A -SEP-363856-Gi1/&β;1/&γ;2 Show 5.26 Single 8WC3 SEP-363856 8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2 Show 5.26 Consensus go_adhesion Orthosteric Ligand 7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2 Show 5.26 Consensus go_class-b2 Orthosteric Ligand go_adhesion Show 5.26 Consensus mt1_on Orthosteric Ligand 7VGY-MT1 -2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1 -Ramelteon-Gi1/&β;1/&γ;2 Show 5.00 Single 1F88 11-cis-Retinal 1F88-Rhodopsin-11-cis-Retinal Show 5.00 Single 1GZM 11-cis-Retinal 1GZM-Rhodopsin-11-cis-Retinal Show 5.00 Single 2PED 9-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal Show 5.00 Single 2Z73 11-cis-Retinal 2Z73-Rhodopsin-11-cis-Retinal Show 5.00 Single 3AYN 9-cis-Retinal 3AYN-Rhodopsin-9-cis-Retinal Show 5.00 Single 3C9L 11-cis-Retinal 3C9L-Rhodopsin-11-cis-Retinal Show 5.00 Single 3VG9 ZM241385 3VG9-A2A -ZM241385-Antibody Show 5.00 Single 6B73 PubChem 131955138 6B73-κ-PubChem 131955138 Show 5.00 Single 6C1Q NDT9513727 6C1Q-C5a1 -PMX53-NDT9513727 Show 5.00 Single 6FKB PubChem 132473038 6FKB-Rhodopsin-PubChem 132473038 Show 5.00 Single 6KUY PubChem 145704643 6KUY-α2a -PubChem 145704643 Show 5.00 Single 6NWE Octyl Beta-D-Glucopyranoside 6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT) Show 5.00 Single 6OYA All-trans-retinal 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 5.00 Single 6TQ6 PubChem 145714283 6TQ6-OX1 -PubChem 145714283 Show 5.00 Single 7DD7 Ca; Ca; Tryptophan; Evocalcet 7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet Show 5.00 Single 7M3F Ca; Ca; Tryptophan; Cinacalcet; PO4 7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4 Show 5.00 Single 7M3F Ca; Ca; Tryptophan; Cinacalcet; PO4 7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4 Show 5.00 Single 7T6S PubChem 24776341 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 Show 5.00 Single 7T8X Acetylcholine 7T8X-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 5.00 Single 7T90 Acetylcholine 7T90-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 5.00 Single 7YM8 Oxymetazoline 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 Show 5.00 Single 8DU3 PubChem 105526064 8DU3-A2A -PubChem 105526064 Show 5.00 Single 8HOC Imetit 8HOC-H4 -Imetit-Gi1/&β;1/&γ;2 Show 5.00 Single 8SZF Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW Show 5.00 Single 8U8F PML 8U8F-GPR3-PML-Gs/&β;1/&γ;2 Show 5.00 Consensus a2a_off_allo Orthosteric Ligand 6ZDR-A2A -HMS1413f12-Na 6GT3-A2A -Imaradenant-Na 8CU7-A2A -LJ-4517-Na 5OLV-A2A -LUAA41063-Na 5N2R-A2A -PubChem 92460631; psb36-Na 5MZJ-A2A -Theophylline-Na 5OLO-A2A -Tozadenant-Na 5OLH-A2A -Vipadenant-Na 5NM4-A2A -ZM241385-Na 8GNE-A2A -KW-6356-Na 8JWZ-A2A -AB928-Na 5MZP-A2A -Caffeine-Na 8CIC-A2A -Etrumadenant-Na Show 5.00 Consensus alpha1_on Orthosteric Ligand alpha1a_on Show 5.00 Consensus alpha1a_on Orthosteric Ligand 7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 5.00 Consensus gi_histamine Orthosteric Ligand 8HN8-H4 -Histamine-Gi1/&β;1/&γ;2 8HOC-H4 -Imetit-Gi1/&β;1/&γ;2 Show 5.00 Consensus gs_histamine Orthosteric Ligand 7YFC-H4 -Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4 -Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 5.00 Consensus gt_class-a Orthosteric Ligand gt_opsin Show 5.00 Consensus gt_opsin Orthosteric Ligand gt_sensory Show 5.00 Consensus gt_sensory Orthosteric Ligand 6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1 Show 5.00 Consensus h4_on Orthosteric Ligand 7YFC-H4 -Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4 -Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 5.00 Consensus m2_on Orthosteric Ligand 7T8X-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 5.00 Consensus melatonin_on Orthosteric Ligand mt1_on mt2_on Show 5.00 Consensus mglu_on Other Ligand mglu2_on mglu4_on Show 5.00 Consensus nts1_on_allo Other Ligand 8JPB-NTS1 -Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 Show 5.00 Consensus opsin_off Orthosteric Ligand 1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal Show 5.00 Consensus smo_on_allo Other Ligand 6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2 Show 4.76 Single 2YDO Adenosine 2YDO-A2A -Adenosine Show 4.76 Single 3RZE Cidoxepin 3RZE-H1 -Cidoxepin Show 4.76 Single 3UZC PubChem 135566609 3UZC-A2A -PubChem 135566609 Show 4.76 Single 4DKL Beta-funaltrexamine 4DKL-μ-Beta-funaltrexamine Show 4.76 Single 4MQT Iperoxo 4MQT-M2 -Iperoxo-LY2119620 Show 4.76 Single 4N6H Naltrindole 4N6H-δ-Naltrindole-Na Show 4.76 Single 5IU7 Q27456346 5IU7-A2A -Q27456346-Na Show 4.76 Single 5JTB ZM241385 5JTB-A2A -ZM241385 Show 4.76 Single 5K2B ZM241385 5K2B-A2A -ZM241385-Na Show 4.76 Single 5TE3 Octyl Beta-D-Glucopyranoside 5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside Show 4.76 Single 5UVI ZM241385 5UVI-A2A -ZM241385 Show 4.76 Single 6AQF ZM241385 6AQF-A2A -ZM241385 Show 4.76 Single 6FK8 PubChem 132473035 6FK8-Rhodopsin-PubChem 132473035 Show 4.76 Single 6K41 Dexmedetomidine 6K41-α2b -Dexmedetomidine-Go/&β;1/&γ;2 Show 4.76 Single 6MH8 ZM241385 6MH8-A2A -ZM241385 Show 4.76 Single 6PEL Citronellol 6PEL-Rhodopsin-Citronellol-Gt(CT) Show 4.76 Single 6TPK Retosiban 6TPK-OT-Retosiban Show 4.76 Single 6TPN HTL6641 6TPN-OX2 -HTL6641 Show 4.76 Single 6WH4 Methiothepin 6WH4-5-HT2A -Methiothepin Show 4.76 Single 6WJC Atropine 6WJC-M1 -Atropine-Muscarinic toxin 7 Show 4.76 Single 6ZDR HMS1413f12 6ZDR-A2A -HMS1413f12-Na Show 4.76 Single 6ZG9 GSK1034702 6ZG9-M1 -GSK1034702 Show 4.76 Single 7CMV PD128907 7CMV-D3 -PD128907-Gi1/&β;1/&γ;2 Show 4.76 Single 7E33 BRL-54443 7E33-5-HT1E -BRL-54443-Gi1/&β;1/&γ;2 Show 4.76 Single 7EJ8 Brimonidine 7EJ8-α2a -Brimonidine-Go/&β;1/&γ;2 Show 4.76 Single 7EJA Dexmedetomidine 7EJA-α2a -Dexmedetomidine-Go/&β;1/&γ;2 Show 4.76 Single 7T32 ZM241385 7T32-A2A -ZM241385 Show 4.76 Single 7T94 Acetylcholine 7T94-M2 -Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 Show 4.76 Single 7TRS Acetylcholine 7TRS-M4 -Acetylcholine-Gi1/&β;1/&γ;2 Show 4.76 Single 7WC9 PubChem 162421364 7WC9-5-HT2A -PubChem 162421364 Show 4.76 Single 7WVU fMLF 7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 Show 4.76 Single 7ZBE 11-cis-Retinal 7ZBE-Rhodopsin-11-cis-Retinal Show 4.76 Single 8FCZ 11-cis-Retinal 8FCZ-Rhodopsin-11-cis-Retinal Show 4.76 Single 8H4L Doconexent 8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 4.76 Single 8HNM VUF11222 8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2 Show 4.76 Single 8JLK Ulotaront 8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2 Show 4.76 Single 8JLN T1AM 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 Show 4.76 Single 8JSP Ulotaront 8JSP-5-HT1A -Ulotaront-Gi1/&β;1/&γ;2 Show 4.76 Single 8THK A61603 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.76 Single 8THL Epinephrine 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.76 Single 8UHB RO5256390 8UHB-TA1-RO5256390-Gs/&β;1/&γ;2 Show 4.76 Single 8W88 SEP-363856 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 Show 4.76 Single 8WPG Tryptophan; Cinacalcet; PO4; Ca 8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca Show 4.76 Single 9AXF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 4.76 Consensus 5ht1e_on Orthosteric Ligand 7E33-5-HT1E -BRL-54443-Gi1/&β;1/&γ;2 Show 4.76 Consensus 5ht2a_on Orthosteric Ligand 7RAN-5-HT2A -PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A -DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.76 Consensus alpha2b_on Orthosteric Ligand 6K41-α2b -Dexmedetomidine-Go/&β;1/&γ;2 Show 4.76 Consensus dop_off_allo Orthosteric Ligand 4N6H-δ-Naltrindole-Na Show 4.76 Consensus ghrelin_off Orthosteric Ligand 6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457 Show 4.76 Consensus gi_melatonin Orthosteric Ligand 7VGY-MT1 -2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1 -Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2 -Ramelteon-Gi1/&β;1/&γ;1 Show 4.76 Consensus m1_off_allo Orthosteric Ligand 6WJC-M1 -Atropine-Muscarinic toxin 7 Show 4.76 Consensus ot_off Orthosteric Ligand 6TPK-OT-Retosiban Show 4.76 Consensus sensory_off Orthosteric Ligand opsin_off Show 4.76 Consensus vasopressin-ot_off Orthosteric Ligand ot_off Show 4.65 Consensus gs_calcitonin Orthosteric Ligand gs_ct gs_cgrp Show 4.55 Single 3EML ZM241385 3EML-A2A -ZM241385 Show 4.55 Single 3NY8 ICI 118-551 3NY8-β2 -ICI 118-551 Show 4.55 Single 3NYA (S)-Alprenolol 3NYA-β2 -(S)-Alprenolol Show 4.55 Single 3ZPQ 4-(piperazin-1- yl)-1H-indole 3ZPQ-β1 -4-(piperazin-1- yl)-1H-indole-Na Show 4.55 Single 3ZPR 4-methyl-2-(piperazin-1-yl) 3ZPR-β1 -4-methyl-2-(piperazin-1-yl)-Na Show 4.55 Single 4DAJ Tiotropium 4DAJ-M3 -Tiotropium Show 4.55 Single 4EIY ZM241385 4EIY-A2A -ZM241385-Na Show 4.55 Single 4EJ4 Naltrindole 4EJ4-δ-Naltrindole Show 4.55 Single 4GBR (S)-Carazolol 4GBR-β2 -(S)-Carazolol Show 4.55 Single 4MQS Iperoxo 4MQS-M2 -Iperoxo Show 4.55 Single 4U14 Tiotropium 4U14-M3 -Tiotropium Show 4.55 Single 4U16 N-Methyl Scopolamine 4U16-M3 -N-Methyl Scopolamine Show 4.55 Single 4X1H Nonyl Beta-D-Glucopyranoside 4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT) Show 4.55 Single 5DSG Tiotropium 5DSG-M4 -Tiotropium Show 4.55 Single 5IU8 Q27456347 5IU8-A2A -Q27456347-Na Show 4.55 Single 5K2A ZM241385 5K2A-A2A -ZM241385-Na Show 4.55 Single 5OLG ZM241385 5OLG-A2A -ZM241385-Na Show 4.55 Single 5OLZ PubChem 135566609 5OLZ-A2A -PubChem 135566609-Na Show 4.55 Single 5OM1 PubChem 135566609 5OM1-A2A -PubChem 135566609-Na Show 4.55 Single 5TGZ AM6538 5TGZ-CB1 -AM6538 Show 4.55 Single 5VRA ZM241385 5VRA-A2A -ZM241385-Na Show 4.55 Single 5YC8 N-Methyl Scopolamine 5YC8-M2 -N-Methyl Scopolamine Show 4.55 Single 5ZK8 N-Methyl Scopolamine 5ZK8-M2 -N-Methyl Scopolamine Show 4.55 Single 5ZKC N-Methyl Scopolamine 5ZKC-M2 -N-Methyl Scopolamine Show 4.55 Single 6FK7 PubChem 132473034 6FK7-Rhodopsin-PubChem 132473034 Show 4.55 Single 6FKC PubChem 132473039 6FKC-Rhodopsin-PubChem 132473039 Show 4.55 Single 6IIV Daltroban 6IIV-TP-Daltroban Show 4.55 Single 6K42 Dexmedetomidine 6K42-α2b -Dexmedetomidine-Gi1/&β;1/&γ;2 Show 4.55 Single 6PS0 (S)-Carazolol 6PS0-β2 -(S)-Carazolol Show 4.55 Single 6PS2 (S)-Alprenolol 6PS2-β2 -(S)-Alprenolol Show 4.55 Single 6S0L ZM241385 6S0L-A2A -ZM241385 Show 4.55 Single 6WHA DB13948 6WHA-5-HT2A -DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.55 Single 7DB6 Ramelteon 7DB6-MT1 -Ramelteon-Gi1/&β;1/&γ;2 Show 4.55 Single 7E32 Serotonin 7E32-5-HT1D -Serotonin-Gi1/&β;1/&γ;2 Show 4.55 Single 7EPF NAM597 7EPF-mGlu2; mGlu2-NAM597 Show 4.55 Single 7PYR PSB-2115 7PYR-A2A -PSB-2115 Show 4.55 Single 7TRP Iperoxo 7TRP-M4 -Iperoxo-LY2033298-Gi1/&β;1/&γ;2 Show 4.55 Single 7VIE S1P 7VIE-S1P1 -S1P-Gi1/&β;1/&γ;2 Show 4.55 Single 7VIF (S)-FTY720-P 7VIF-S1P1 -(S)-FTY720-P-Gi1/&β;1/&γ;2 Show 4.55 Single 7VKT LTB4 7VKT-BLT1 -LTB4-Gi1/&β;1/&γ;2 Show 4.55 Single 7WC7 Lisuride 7WC7-5-HT2A -Lisuride Show 4.55 Single 7XTC 5-CT 7XTC-5-HT7 -5-CT-Gs/&β;1/&γ;2 Show 4.55 Single 8CIC Etrumadenant 8CIC-A2A -Etrumadenant-Na Show 4.55 Single 8CU6 LJ-4517 8CU6-A2A -LJ-4517 Show 4.55 Single 8CU7 LJ-4517 8CU7-A2A -LJ-4517-Na Show 4.55 Single 8DZS GR89,696 8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2 Show 4.55 Single 8JJO Alprenolol 8JJO-β2 -Alprenolol Show 4.55 Single 8JLJ T1AM 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2 Show 4.55 Single 8W87 METH 8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 4.55 Single 8W8A RO5256390 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 Show 4.55 Consensus 5ht1d_on Orthosteric Ligand 7E32-5-HT1D -Serotonin-Gi1/&β;1/&γ;2 Show 4.55 Consensus 5ht2_off Orthosteric Ligand 5ht2a_off 5ht2b_off 5ht2c_off Show 4.55 Consensus 5ht7_on Orthosteric Ligand 7XTC-5-HT7 -5-CT-Gs/&β;1/&γ;2 Show 4.55 Consensus a2_off Orthosteric Ligand a2a_off Show 4.55 Consensus a2a_off Orthosteric Ligand 8C9W-A2A -Etrumadenant 3UZA-A2A -GTPL9236 8GNG-A2A -Istradefylline 5UIG-A2A -J3.651.884G 8CU6-A2A -LJ-4517 7PX4-A2A -PSB-2113 7PYR-A2A -PSB-2115 8DU3-A2A -PubChem 105526064 8JWY-A2A -PubChem 168451710 5K2D-A2A -ZM241385 Show 4.55 Consensus adenosine_on Orthosteric Ligand a1_on a2_on Show 4.55 Consensus alpha2_on Orthosteric Ligand alpha2a_on alpha2b_on Show 4.55 Consensus alpha_on Orthosteric Ligand alpha1_on alpha2_on Show 4.55 Consensus amine_on Orthosteric Ligand adrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on Show 4.55 Consensus blt1_on Orthosteric Ligand 7VKT-BLT1 -LTB4-Gi1/&β;1/&γ;2 Show 4.55 Consensus blt_on Orthosteric Ligand blt1_on Show 4.55 Consensus dop_off Orthosteric Ligand 4EJ4-δ-Naltrindole Show 4.55 Consensus gi_leukotriene Orthosteric Ligand 7VKT-BLT1 -LTB4-Gi1/&β;1/&γ;2 Show 4.55 Consensus go_muscarinic Orthosteric Ligand 8E9X-M4 -2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2 -Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2 Show 4.55 Consensus gq_amine Orthosteric Ligand gq_muscarinic gq_histamine Show 4.55 Consensus histamine_on Orthosteric Ligand h1_on h4_on Show 4.55 Consensus leuko_on Orthosteric Ligand blt_on Show 4.55 Consensus m2_on_allo Orthosteric Ligand 7T94-M2 -Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2 -Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 Show 4.55 Consensus m4_off Orthosteric Ligand 5DSG-M4 -Tiotropium Show 4.55 Consensus m4_on_allo Orthosteric Ligand 7TRP-M4 -Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4 -Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4 -Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2 Show 4.55 Consensus muscarinic_on Orthosteric Ligand m2_on m3_on m4_on m1_on Show 4.55 Consensus nucleotide_on Orthosteric Ligand adenosine_on Show 4.55 Consensus tachykinin_off Orthosteric Ligand nk1_off Show 4.55 Consensus tar_on Orthosteric Ligand ta1_on Show 4.55 Consensus tp_off Orthosteric Ligand 6IIV-TP-Daltroban 6IIU-TP-Ramatroban Show 4.35 Single 2RH1 (S)-Carazolol 2RH1-β2 -(S)-Carazolol Show 4.35 Single 2YCW (S)-Carazolol 2YCW-β1 -(S)-Carazolol Show 4.35 Single 4WW3 All-trans-retinal 4WW3-Rhodopsin-All-trans-retinal Show 4.35 Single 5CGC HTL14242 5CGC-mGlu5 -HTL14242 Show 4.35 Single 5D6L (S)-Carazolol 5D6L-β2 -(S)-Carazolol Show 4.35 Single 5IUA Q27456348 5IUA-A2A -Q27456348-Na Show 4.35 Single 5N2R PubChem 92460631; psb36 5N2R-A2A -PubChem 92460631; psb36-Na Show 4.35 Single 5N2S PSB36 5N2S-A1 -PSB36 Show 4.35 Single 5NM2 ZM241385 5NM2-A2A -ZM241385-Na Show 4.35 Single 5OM4 PubChem 135566609 5OM4-A2A -PubChem 135566609-Na Show 4.35 Single 5X7D (S)-Carazolol 5X7D-β2 -(S)-Carazolol-PubChem 129318963 Show 4.35 Single 5XPR Bosentan 5XPR-ETB -Bosentan Show 4.35 Single 5ZK3 Quinuclidinyl benzilate hydrobromide 5ZK3-M2 -Quinuclidinyl benzilate hydrobromide Show 4.35 Single 6GDG NECA 6GDG-A2A -NECA-Gs/&β;1/&γ;1 Show 4.35 Single 6LFL PubChem 153466996 6LFL-CXCR2-PubChem 153466996 Show 4.35 Single 6LPL ZM241385 6LPL-A2A -ZM241385-Na Show 4.35 Single 6OIK Iperoxo 6OIK-M2 -Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2 Show 4.35 Single 6PS6 Timolol 6PS6-β2 -Timolol Show 4.35 Single 6S0Q ZM241385 6S0Q-A2A -ZM241385 Show 4.35 Single 6W2X PubChem 23727970 6W2X-GABAB1 , GABAB2 -PubChem 5311042-PubChem 23727970 Show 4.35 Single 6WQA ZM241385 6WQA-A2A -ZM241385-Na Show 4.35 Single 7C4S S1P 7C4S-S1P3 -S1P Show 4.35 Single 7EUO fMLF 7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 Show 4.35 Single 7RM5 ZM241385 7RM5-A2A -ZM241385-Na Show 4.35 Single 7VUH JNJ-63533054 7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2 Show 4.35 Single 8C9W Etrumadenant 8C9W-A2A -Etrumadenant Show 4.35 Single 8EFB Oliceridine 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 Show 4.35 Single 8FYN ZM241385 8FYN-A2A -ZM241385-Na Show 4.35 Single 8GDC PGE2 8GDC-EP3 -PGE2-Gi1/&β;1/&γ;2 Show 4.35 Single 8GNE KW-6356 8GNE-A2A -KW-6356-Na Show 4.35 Single 8J19 PubChem 127045422 8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2 Show 4.35 Single 8QOT Nanobody E 8QOT-μ-Nanobody E Show 4.35 Single 8SZG Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2 Show 4.35 Single 8SZI Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2 Show 4.35 Single 8WPU Tryptophan; Cinacalcet; PO4; Ca 8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.35 Single 9AXF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 4.35 Consensus 5ht1_on Orthosteric Ligand 5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on Show 4.35 Consensus a1_off Orthosteric Ligand 5UEN-A1 -DU172 5N2S-A1 -PSB36 Show 4.35 Consensus a2a_on Orthosteric Ligand 6GDG-A2A -NECA-Gs/&β;1/&γ;1 Show 4.35 Consensus alpha2a_on Orthosteric Ligand 7EJ0-α2a -L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a -Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a -W58-Go/&β;1/&γ;2 7W6P-α2a -W96-Go/&β;1/&γ;2 7EJ8-α2a -Brimonidine-Go/&β;1/&γ;2 7EJA-α2a -Dexmedetomidine-Go/&β;1/&γ;2 Show 4.35 Consensus amine_off Orthosteric Ligand adrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off Show 4.35 Consensus beta2_off Orthosteric Ligand 6PS2-β2 -(S)-Alprenolol 6PS3-β2 -(S)-Carvedilol 6PS5-β2 -(S)-Propranolol 6PS6-β2 -Timolol 2RH1-β2 -(S)-Carazolol 6PS4-β2 -ICI 118-551 3NY9-β2 -PubChem 913103 Show 4.35 Consensus beta_off Orthosteric Ligand beta1_off beta2_off Show 4.35 Consensus ep3_on Orthosteric Ligand 8GDC-EP3 -PGE2-Gi1/&β;1/&γ;2 Show 4.35 Consensus go_amine Orthosteric Ligand go_adrenergic go_muscarinic go_5ht Show 4.35 Consensus gs_muscarinic Orthosteric Ligand 8E9W-M3 -2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3 -Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.35 Consensus m2_off Orthosteric Ligand 5ZKB-M2 -AF-DX 384 5ZKC-M2 -N-Methyl Scopolamine 5ZK3-M2 -Quinuclidinyl benzilate hydrobromide Show 4.35 Consensus m3_on Orthosteric Ligand 8E9Z-M3 -Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3 -2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.35 Consensus ta1_on Orthosteric Ligand 8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 4.17 Single 2YDV NECA 2YDV-A2A -NECA Show 4.17 Single 3UON Quinuclidinyl benzilate hydrobromide 3UON-M2 -Quinuclidinyl benzilate hydrobromide Show 4.17 Single 4DJH JDTic 4DJH-κ-JDTic Show 4.17 Single 4OO9 Mavoglurant 4OO9-mGlu5 -Mavoglurant Show 4.17 Single 4U15 Tiotropium 4U15-M3 -Tiotropium Show 4.17 Single 4UHR CGS21680 4UHR-A2A -CGS21680 Show 4.17 Single 4Z34 ONO-9780307 4Z34-LPA1 -ONO-9780307 Show 4.17 Single 5A8E 7-Methylcyanopindolol 5A8E-β1 -7-Methylcyanopindolol-Na Show 4.17 Single 5D5A (S)-Carazolol 5D5A-β2 -(S)-Carazolol Show 4.17 Single 5D5B (S)-Carazolol 5D5B-β2 -(S)-Carazolol Show 4.17 Single 5G53 NECA 5G53-A2A -NECA-Gs Show 4.17 Single 5X93 K-8794 5X93-ETB -K-8794 Show 4.17 Single 5ZHP PubChem 134828589 5ZHP-M3 -PubChem 134828589 Show 4.17 Single 5ZKB AF-DX 384 5ZKB-M2 -AF-DX 384 Show 4.17 Single 6E59 L-760735 6E59-NK1 -L-760735 Show 4.17 Single 6GT3 Imaradenant 6GT3-A2A -Imaradenant-Na Show 4.17 Single 6J20 Aprepitant 6J20-NK1 -Aprepitant Show 4.17 Single 6J21 Aprepitant 6J21-NK1 -Aprepitant Show 4.17 Single 6OL9 Tiotropium 6OL9-M5 -Tiotropium Show 4.17 Single 6TQ7 SB-334867 6TQ7-OX1 -SB-334867 Show 4.17 Single 7EPE NAM563 7EPE-mGlu-NAM563 Show 4.17 Single 7EW1 Siponimod 7EW1-S1P5 -Siponimod-Gi1/&β;1/&γ;2 Show 4.17 Single 7FEE PubMed 104895 7FEE-CB1 -PubMed 104895-ZCZ011 Show 4.17 Single 7PX4 PSB-2113 7PX4-A2A -PSB-2113 Show 4.17 Single 7T2H Lofentanil 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 Show 4.17 Single 7U2L PubChem 163201242 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 Show 4.17 Single 7VGY 2-Iodomelatonin 7VGY-MT1 -2-Iodomelatonin-Gi1/&β;1/&γ;2 Show 4.17 Single 7VIG CBP-307 7VIG-S1P1 -CBP-307-Gi1/&β;1/&γ;2 Show 4.17 Single 7W41 PD176252 7W41-BB2 -PD176252 Show 4.17 Single 7W6P W96 7W6P-α2a -W96-Go/&β;1/&γ;2 Show 4.17 Single 7W7E W58 7W7E-α2a -W58-Go/&β;1/&γ;2 Show 4.17 Single 7WVX Humanin 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 Show 4.17 Single 8DZP momSalB 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 Show 4.17 Single 8EF5 Fentanyl 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 Show 4.17 Single 8G05 6-OAU 8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2 Show 4.17 Single 8HDO BAY 60-6583 8HDO-A2B -BAY 60-6583-Gs/&β;1/&γ;2 Show 4.17 Single 8ID3 9-Hydroxystearic acid 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 Show 4.17 Single 8IRR Rotigotine 8IRR-D1 -Rotigotine-Gs/&β;1/&γ;2 Show 4.17 Single 8JD0 J9R 8JD0-mGlu2; mGlu3-Glutamate-J9R Show 4.17 Single 8JPB PubChem 118610427; GDP; Mg 8JPB-NTS1 -Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2 Show 4.17 Single 8JXX Clobenpropit 8JXX-H4 -Clobenpropit-Gi1/&β;1/&γ;2 Show 4.17 Single 8SZH Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2 Show 4.17 Single 8X16 Piclidenoson 8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2 Show 4.17 Single 8XJM Latanoprost 8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2 Show 4.17 Single 9AYF Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4 9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2 Show 4.17 Consensus 5ht1b_on Orthosteric Ligand 6G79-5-HT1B -Donitriptan-Go/&β;1/&γ;2 Show 4.17 Consensus 5ht_off Orthosteric Ligand 5ht2_off 5ht5_off 5ht1_off Show 4.17 Consensus a2_on Orthosteric Ligand a2a_on a2b_on Show 4.17 Consensus a2b_on Orthosteric Ligand 8HDP-A2B -Adenosine-Gs/&β;1/&γ;2 8HDO-A2B -BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B -NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B -PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 Show 4.17 Consensus adenosine_off Orthosteric Ligand a1_off a2_off Show 4.17 Consensus angiotensin_off Orthosteric Ligand at1_off at2_off Show 4.17 Consensus bb2_off Orthosteric Ligand 7W41-BB2 -PD176252 Show 4.17 Consensus beta1_off Orthosteric Ligand 2VT4-β1 -Cyanopindolol 2YCZ-β1 -Iodocyanopindolol Show 4.17 Consensus bombesin_off Orthosteric Ligand bb2_off Show 4.17 Consensus class-a_off Orthosteric Ligand sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off Show 4.17 Consensus dopamine_off Orthosteric Ligand d3_off d2_off d4_off Show 4.17 Consensus gi_amine Orthosteric Ligand gi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine Show 4.17 Consensus gi_muscarinic Orthosteric Ligand 7TRS-M4 -Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4 -Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4 -PubChem 9864275-Gi1/&β;1/&γ;2 Show 4.17 Consensus go_adrenergic Orthosteric Ligand 7EJ0-α2a -L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a -Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a -W58-Go/&β;1/&γ;2 7W6P-α2a -W96-Go/&β;1/&γ;2 6K41-α2b -Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a -Brimonidine-Go/&β;1/&γ;2 7EJA-α2a -Dexmedetomidine-Go/&β;1/&γ;2 Show 4.17 Consensus gs_adenosine Orthosteric Ligand 8HDP-A2B -Adenosine-Gs/&β;1/&γ;2 8HDO-A2B -BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A -NECA-Gs/&β;1/&γ;1 7XY7-A2B -NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B -PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 Show 4.17 Consensus gs_nucleotide Orthosteric Ligand gs_adenosine Show 4.17 Consensus kop_off Orthosteric Ligand 4DJH-κ-JDTic Show 4.17 Consensus lpa_off Orthosteric Ligand lpa1_off Show 4.17 Consensus m3_off Orthosteric Ligand 4U15-M3 -Tiotropium 4U16-M3 -N-Methyl Scopolamine 5ZHP-M3 -PubChem 134828589 Show 4.17 Consensus m5_off Orthosteric Ligand 6OL9-M5 -Tiotropium Show 4.17 Consensus mglu2_on Other Ligand 7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2 Show 4.17 Consensus muscarinic_off Orthosteric Ligand m2_off m3_off m4_off m5_off m1_off Show 4.17 Consensus nk1_off Orthosteric Ligand 6J20-NK1 -Aprepitant 6HLL-NK1 -CP99994 6E59-NK1 -L-760735 Show 4.17 Consensus s1p2_on Orthosteric Ligand 7T6B-S1P2 -S1P-chim(NtGi1L-G13)/&β;1/&γ;2 Show 4.17 Consensus s1p5_on Orthosteric Ligand 7EW1-S1P5 -Siponimod-Gi1/&β;1/&γ;2 Show 4.00 Single 3D4S Timolol Maleate 3D4S-β2 -Timolol Maleate Show 4.00 Single 4AMI Bucindolol 4AMI-β1 -Bucindolol Show 4.00 Single 4N4W SANT-1 4N4W-SMO-SANT-1 Show 4.00 Single 4OR2 FITM 4OR2-mGlu1; mGlu1-FITM Show 4.00 Single 4Z36 ONO-3080573 4Z36-LPA1 -ONO-3080573 Show 4.00 Single 5CXV Tiotropium 5CXV-M1 -Tiotropium Show 4.00 Single 5F8U Cyanopindolol 5F8U-β1 -Cyanopindolol Show 4.00 Single 5LWE Vercirnon 5LWE-CCR9-Vercirnon Show 4.00 Single 5X33 BIIL260 5X33-BLT1 -BIIL260 Show 4.00 Single 6AK3 Dinoprostone IPGE2 6AK3-EP3 -Dinoprostone IPGE2 Show 4.00 Single 6H7N (S)-Xamoterol 6H7N-β1 -(S)-Xamoterol Show 4.00 Single 6H7O Cyanopindolol 6H7O-β1 -Cyanopindolol Show 4.00 Single 6HLP Netupitant 6HLP-NK1 -Netupitant Show 4.00 Single 6IIU Ramatroban 6IIU-TP-Ramatroban Show 4.00 Single 6KQI PubMed 104895 6KQI-CB1 -PubMed 104895-ORG27569 Show 4.00 Single 6ME6 2-Phenylmelatonin 6ME6-MT2 -2-Phenylmelatonin Show 4.00 Single 6W2Y PubChem 23727970 6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970 Show 4.00 Single 6W2Y PubChem 23727970 6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970 Show 4.00 Single 6ZG4 HTL0009936 6ZG4-M1 -HTL0009936 Show 4.00 Single 7EO4 BAF312 7EO4-S1P1 -BAF312-Gi1/&β;1/&γ;2 Show 4.00 Single 7EXD Lasmiditan 7EXD-5-HT1F -Lasmiditan-Gi1/&β;1/&γ;2 Show 4.00 Single 7JNI Olodanrigan 7JNI-AT2 -Olodanrigan Show 4.00 Single 7K15 MKD046 7K15-BLT1 -MKD046-Na Show 4.00 Single 7T6B S1P 7T6B-S1P2 -S1P-chim(NtGi1L-G13)/&β;1/&γ;2 Show 4.00 Single 7W0L PubChem 122701908 7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 4.00 Single 7W0L PubChem 122701908 7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2 Show 4.00 Single 7XY7 NECA 7XY7-A2B -NECA-chim(NtGi1-Gs)/&β;1/&γ;2 Show 4.00 Single 7YIT Nalfurafine 7YIT-κ-Nalfurafine Show 4.00 Single 8E9W 2-Deoxycytidine 8E9W-M3 -2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.00 Single 8IRS Rotigotine 8IRS-D2 -Rotigotine-Gi1/&β;1/&γ;2 Show 4.00 Single 8JWY PubChem 168451710 8JWY-A2A -PubChem 168451710 Show 4.00 Single 8JWZ AB928 8JWZ-A2A -AB928-Na Show 4.00 Single 8T3Q DHA 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 4.00 Consensus 5ht1f_on Orthosteric Ligand 7EXD-5-HT1F -Lasmiditan-Gi1/&β;1/&γ;2 Show 4.00 Consensus adgrg_on Orthosteric Ligand adgrg2_on adgrg3_on Show 4.00 Consensus at2_off Orthosteric Ligand 7JNI-AT2 -Olodanrigan Show 4.00 Consensus blt1_off Orthosteric Ligand 7K15-BLT1 -MKD046-Na Show 4.00 Consensus blt_off Orthosteric Ligand blt1_off Show 4.00 Consensus cannabinoid_off Orthosteric Ligand cb1_off cb2_off Show 4.00 Consensus cb1_off_allo Orthosteric Ligand 6KQI-CB1 -PubMed 104895-ORG27569 Show 4.00 Consensus ccr9_off_allo Other Ligand 5LWE-CCR9-Vercirnon Show 4.00 Consensus class-b2_on Orthosteric Ligand adgrg_on Show 4.00 Consensus d2_off Orthosteric Ligand 6CM4-D2 -Risperidone 6LUQ-D2 -Haloperidol 7DFP-D2 -Spiperone Show 4.00 Consensus gs_amine Orthosteric Ligand gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar Show 4.00 Consensus leuko_off Orthosteric Ligand blt_off cyslt_off Show 4.00 Consensus lpa1_off Orthosteric Ligand 4Z36-LPA1 -ONO-3080573 4Z34-LPA1 -ONO-9780307 4Z35-LPA1 -ONO-9910539 7YU4-LPA1 -ONO-0740556 Show 4.00 Consensus m1_off Orthosteric Ligand 5CXV-M1 -Tiotropium Show 4.00 Consensus m4_on Orthosteric Ligand 7TRS-M4 -Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4 -Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4 -2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4 -PubChem 9864275-Gi1/&β;1/&γ;2 Show 4.00 Consensus opioid_off Orthosteric Ligand kop_off mop_off nop_off dop_off Show 4.00 Consensus peptide_off Orthosteric Ligand opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off Show 3.85 Single 2YCZ Iodocyanopindolol 2YCZ-β1 -Iodocyanopindolol Show 3.85 Single 4BVN Cyanopindolol 4BVN-β1 -Cyanopindolol-Na Show 3.85 Single 4Z35 ONO-9910539 4Z35-LPA1 -ONO-9910539 Show 3.85 Single 5UNH PubChem 126456406 5UNH-AT2 -PubChem 126456406 Show 3.85 Single 6G79 Donitriptan 6G79-5-HT1B -Donitriptan-Go/&β;1/&γ;2 Show 3.85 Single 6K1Q IRL2500 6K1Q-ETB -IRL2500 Show 3.85 Single 6M1H Maxadilan 6M1H-PAC1 -Maxadilan-Gs/&β;1/&γ;2 Show 3.85 Single 7CX2 PGE2 7CX2-EP2 -PGE2-Gs/&β;1/&γ;2 Show 3.85 Single 7EW0 Ozanimod 7EW0-S1P1 -Ozanimod-Gi1/&β;1/&γ;2 Show 3.85 Single 7EZC UKA 7EZC-A2A -UKA Show 3.85 Single 7SK8 CCX662 7SK8-ACKR3-CXCL12-CCX662 Show 3.85 Single 7U2K C6-guano 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 Show 3.85 Single 7WVV fMLFII 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 Show 3.85 Single 7X2D Tavapadon 7X2D-D1 -Tavapadon-Gs/&β;1/&γ;2 Show 3.85 Single 7XJI Solabegron 7XJI-β3 -Solabegron-Gs/&β;1/&γ;2 Show 3.85 Single 8E9X 2-Deoxycytidine 8E9X-M4 -2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 Show 3.85 Single 8E9Y PubChem 446603 8E9Y-M3 -PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Single 8FX5 Xanomeline 8FX5-M4 -Xanomeline-Xanomeline-Gi1/&β;1/&γ;2 Show 3.85 Single 8GUT LEI-102 8GUT-CB2 -LEI-102-Gi1/&β;1/&γ;2 Show 3.85 Single 8ID8 TUG-891 8ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 Show 3.85 Single 8IQ6 Latanoprost 8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Single 8IUL Latanoprost 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Single 8IYS TUG-891 8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 3.85 Single 8T3O TUG-891 8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Single 8XJO U46619 8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Consensus adgrg2_on Orthosteric Ligand 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 3.85 Consensus beta1_off_allo Orthosteric Ligand 4BVN-β1 -Cyanopindolol-Na Show 3.85 Consensus endothelin_off Orthosteric Ligand etb_off Show 3.85 Consensus etb_off Orthosteric Ligand 5XPR-ETB -Bosentan 6K1Q-ETB -IRL2500 5X93-ETB -K-8794 Show 3.85 Consensus ffa4_on_allo Orthosteric Ligand 8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 3.85 Consensus s1p1_on Orthosteric Ligand 7TD3-S1P1 -S1P-Gi1/&β;1/&γ;2 7TD4-S1P1 -Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1 -(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1 -BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1 -CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1 -Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1 -Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1 -PubChem 4077460-Gi1/&β;1/&γ;2 Show 3.70 Single 3NY9 PubChem 913103 3NY9-β2 -PubChem 913103 Show 3.70 Single 4UG2 CGS21680 4UG2-A2A -CGS21680 Show 3.70 Single 5EE7 MK0893 5EE7-Glucagon-MK0893 Show 3.70 Single 5WF6 UK-432097 5WF6-A2A -UK-432097 Show 3.70 Single 5ZTY AM10257 5ZTY-CB2 -AM10257 Show 3.70 Single 6OMM WKYMVX 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 Show 3.70 Single 6PT3 DPI-287 6PT3-δ-DPI-287 Show 3.70 Single 7SK9 CCX662 7SK9-ACKR3-CCX662 Show 3.70 Single 7XY6 PubChem 11717831 7XY6-A2B -PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2 Show 3.70 Single 8H4I Doconexent 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2 Show 3.70 Single 8JLR A77636 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 Show 3.70 Consensus cb2_off Orthosteric Ligand 5ZTY-CB2 -AM10257 Show 3.70 Consensus fpr2-alx_on Orthosteric Ligand 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2 Show 3.70 Consensus gs_adgr Orthosteric Ligand 7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2 Show 3.70 Consensus gs_class-b2 Orthosteric Ligand gs_adgr Show 3.70 Consensus lipid_on Orthosteric Ligand cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on Show 3.70 Consensus lpl_off Orthosteric Ligand s1p_off lpa_off Show 3.57 Single 4AMJ (S)-Carvedilol 4AMJ-β1 -(S)-Carvedilol Show 3.57 Single 6WIV PubChem 52923113; PubChem 52924645 6WIV-GABAB1 , GABAB2 -PubChem 52923113; PubChem 52924645 Show 3.57 Single 7T6U CGEN-855A 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 Show 3.57 Single 7WVW fMYFINILTL 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 Show 3.57 Single 8G59 TUG-891 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 Show 3.57 Single 8SZI Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW 8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2 Show 3.57 Consensus fpr-alx_on Orthosteric Ligand fpr1-alx_on fpr2-alx_on Show 3.57 Consensus gi_opioid Orthosteric Ligand 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2 Show 3.57 Consensus mop_off Orthosteric Ligand 7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E Show 3.45 Single 3QAK UK-432097 3QAK-A2A -UK-432097 Show 3.45 Single 6HLO Aprepitant 6HLO-NK1 -Aprepitant Show 3.45 Single 7CUM Phospholipid 7CUM-GABAB1 , GABAB2 -CGP54626-Phospholipid Show 3.45 Consensus gi_lpl Orthosteric Ligand 7EW3-S1P3 -S1P-Gi1/&β;1/&γ;2 7TD4-S1P1 -Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1 -(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1 -BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1 -CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1 -Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3 -CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3 -Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1 -LPA-Gi1/&β;1/&γ;2 7YU3-LPA1 -ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1 -Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1 -PubChem 4077460-Gi1/&β;1/&γ;2 Show 3.33 Single 5WF5 UK-432097 5WF5-A2A -UK-432097 Show 3.33 Single 6LW5 WKYMVm 6LW5-FPR2-ALX-WKYMVm Show 3.33 Single 6PT2 KGCHM07 6PT2-δ-KGCHM07 Show 3.33 Single 7TD2 LPA 7TD2-LPA1 -LPA-Gi1/&β;1/&γ;2 Show 3.33 Single 7VVN PTH 7VVN-PTH1-PTH-Gs/&β;1/&γ;2 Show 3.23 Single 6JOD Angiotensin II 6JOD-AT2 -Angiotensin II Show 3.23 Single 6WIV PubChem 52923113; PubChem 52924645 6WIV-GABAB1 , GABAB2 -PubChem 52923113; PubChem 52924645 Show 3.23 Single 7C61 Ergotamine 7C61-5-HT1B -Ergotamine Show 3.23 Consensus go_class-b Orthosteric Ligand go_class-b1 go_class-b2 Show 3.23 Consensus pca1_on Orthosteric Ligand 6M1I-PAC1 -PACAP-Gs/&β;1/&γ;2 Show 3.12 Single 6UUN Adrenomedullin 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 Show 3.12 Single 7LLY Oxyntomodulin 7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2 Show 3.12 Single 7TRY Urocortin 7TRY-CRF2 -Urocortin-chim(NtGi1-G11)/&β;1/&γ;2 Show 3.12 Single 7WBJ PACAP27 7WBJ-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 3.12 Single 7Y35 Abaloparatide 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 Show 3.12 Single 8HCQ Endothelin-1 8HCQ-ETA -Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 3.12 Single 8HCX Endothelin-1 8HCX-ETB -Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 3.12 Consensus eta_on Orthosteric Ligand 8HCQ-ETA -Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 Show 3.12 Consensus gq_class-a Orthosteric Ligand gq_amine gq_peptide Show 3.12 Consensus vpac1_on Orthosteric Ligand 8E3Y-VPAC1 -PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1 -VIP-Gs/&β;1/&γ;2 6VN7-VPAC1 -PACAP-Gs/&β;1/&γ;2 Show 3.03 Single 6NBF Long-acting PTH analog 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 3.03 Single 6NBI Long-acting PTH analog 6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 3.03 Single 6P9Y PACAP 6P9Y-PAC1 -PACAP-Gs/&β;1/&γ;2 Show 3.03 Single 7D3S Secretin 7D3S-Secretin-Secretin-Gs/&β;1/&γ;2 Show 3.03 Single 7W3Z Gastrin Releasing Peptide 7W3Z-BB2 -Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 3.03 Single 7XV3 Lysophosphatidylserine 7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2 Show 3.03 Single 8E3X PACAP27 8E3X-PAC1 -PACAP27-Gs/&β;1/&γ;2 Show 3.03 Single 8FLR PTHrP(1-36) 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 Show 3.03 Consensus ctlike_on Orthosteric Ligand 6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2 Show 3.03 Consensus ghrh_on Orthosteric Ligand 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 Show 3.03 Consensus glp1_on_allo Orthosteric Ligand 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2 Show 2.94 Single 6P9X Corticoliberin 6P9X-CRF1 -Corticoliberin-Gs/&β;1/&γ;2 Show 2.94 Single 6UVA Adrenomedullin-2 6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3 Show 2.94 Single 6VCB GLP-1 6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2 Show 2.94 Single 7S1M Ex4-D-Ala 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 Show 2.94 Single 7VQX PACAP27 7VQX-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 2.94 Consensus endothelin_on Orthosteric Ligand etb_on eta_on Show 2.94 Consensus etb_on Orthosteric Ligand 8HCX-ETB -Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB -IRL1620-Gi1/&β;1/&γ;2 Show 2.94 Consensus glp2_on Orthosteric Ligand 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 Show 2.86 Single 6IGL IRL1620 6IGL-ETB -IRL1620 Show 2.86 Single 6NBH Long-acting PTH analog 6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 2.86 Single 6WZG Secretin 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 Show 2.86 Single 7KI1 Taspoglutide 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 Show 2.86 Single 7VVK PTH 7VVK-PTH1-PTH-Gs/&β;1/&γ;2 Show 2.86 Single 7VVL PTH 7VVL-PTH1-PTH-Gs/&β;1/&γ;2 Show 2.86 Single 8IY6 Endothelin-1 8IY6-ETB -Endothelin-1 Show 2.86 Consensus crf_on Orthosteric Ligand crf2_on crf1_on Show 2.86 Consensus glp1_on Orthosteric Ligand 6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 Show 2.86 Consensus gs_endothelin Orthosteric Ligand 8HCQ-ETA -Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB -Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 Show 2.86 Consensus secretin_on Orthosteric Ligand 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 Show 2.86 Consensus vpac2_on Orthosteric Ligand 7VQX-VPAC1 -PACAP27-Gs/&β;1/&γ;2 Show 2.78 Single 5GLH Endothelin-1 5GLH-ETB -Endothelin-1 Show 2.78 Single 5VAI GLP-1 5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2 Show 2.78 Single 6IGK Endothelin-3 6IGK-ETB -Endothelin-3 Show 2.78 Single 7RBT Tirzepatide 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 Show 2.78 Consensus bb2_on Orthosteric Ligand 7W40-BB2 -Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2 -Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 2.78 Consensus gip_on Orthosteric Ligand 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 Show 2.78 Consensus gip_on_allo Orthosteric Ligand 7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2 Show 2.78 Consensus gq_bombesin Orthosteric Ligand 7W40-BB2 -Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2 -Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2 Show 2.78 Consensus gs_crf Orthosteric Ligand 6P9X-CRF1 -Corticoliberin-Gs/&β;1/&γ;2 Show 2.70 Single 6LPB PACAP 6LPB-PAC1 -PACAP-Gs/&β;1/&γ;1 Show 2.70 Single 6WPW Glucagon derivative ZP3780 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 Show 2.70 Single 8FLS Abaloparatide 8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2 Show 2.70 Single 8FLU Long-acting PTH 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 Show 2.70 Single 8HBD IRL1620 8HBD-ETB -IRL1620-Gi1/&β;1/&γ;2 Show 2.70 Consensus gi_endothelin Orthosteric Ligand 8IY5-ETB -Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB -IRL1620-Gi1/&β;1/&γ;2 Show 2.63 Single 6LRY Sarafotoxin-B 6LRY-ETB -Sarafotoxin-B Show 2.63 Single 7VVM PTH 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 Show 2.63 Single 8JIR SAR425899 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 Show 2.63 Consensus pth1_on Orthosteric Ligand 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 Show 2.63 Consensus vip-pacap_on Orthosteric Ligand vpac1_on vpac2_on pca1_on Show 2.56 Single 7Y36 Teriparatide 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 Show 2.56 Consensus gs_vip-pacap Orthosteric Ligand 8E3Y-VPAC1 -PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1 -PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1 -VIP-Gs/&β;1/&γ;2 6M1I-PAC1 -PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1 -PACAP-Gs/&β;1/&γ;2 Show 2.56 Consensus pth2_on Orthosteric Ligand 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 Show 2.50 Consensus gs_class-b Orthosteric Ligand gs_class-b1 gs_class-b2 Show 2.44 Consensus ct_on Orthosteric Ligand 7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 Show 2.38 Single 7F16 TIP39 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 Show 2.38 Consensus gs_pth Orthosteric Ligand 8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 Show 2.33 Consensus glu_on Orthosteric Ligand 6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2 Show 2.22 Consensus gs_class-b1 Orthosteric Ligand gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf