Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
11x50 6.06875409
2I1x50 5.9454178
32x39 3.345148
42x40 5.111254179
52x42 3.77833608
62x46 4.464569
72x50 7.517569
8E1x50 5.4835187
93x28 5.007506
103x32 8.6925427
113x34 4.59125405
123x42 4.57125468
133x49 6.08254149
143x50 5.71125409
153x51 6.817508
16I2x51 6.187506
17I2x53 7.9435147
184x50 4.462569
19E2 14.31151023
205x39 6.163527
215x47 9.21333627
225x54 3.9475428
235x58 4.72167629
245x60 4.25405
256x41 3.12875428
266x44 5.78625429
276x48 6.54643728
286x49 4.72407
296x51 7.579527
306x52 9.062527
31E3 4.0925424
327x37 4.142505
337x39 4.21125406
347x42 7.64417627
357x49 8.85625469
367x53 4.447509
378x50 7.416254178
38b.1x1 2.8854214
39b.1x16 3.206254224
40b.lhb1x6 2.8554103
41b.lhb1x11 4.1375404
42b.l1x3 8.489589
43b.b2x1 6.072518
44b.b2x5 7.26375407
45b.b3x3 4.10375408
46b.b3x4 5.31375489
47b.b4x4 6.604588
48b.b4x6 8.63571789
49b.l4x2 11.6588404
50b.b5x2 4.54254267
51b.b5x3 5.67083689
52b.b5x5 3.816505
53b.b5x7 5.84125407
54b.l5x1 3.975158
55b.l5x5 6.45437819
56b.b6x5 4.14125406
57b.l6x5 4.974164
58b.b7x1 5.401254164
59b.b7x4 3.9554158
60b.b8x4 4.899176156
61b.l8x3 2.815403
62b.l9x3 6.3475699
63b.l9x6 3.98611918
64b.b10x5 3.98509
65b.b11x4 5.77875499
66b.l11x2 6.298599
67b.b12x6 6.69286798
68b.b13x7 7.1945127
69b.l13x3 7.235409
70b.l13x6 3.84409
71b.b15x2 5.85875456
72b.b16x4 9.9954126
73b.b16x6 9.1245128
74b.b16x7 5.4225409
75b.b17x7 7.9475458
76b.l17x3 8.80833659
77b.l17x6 6.71875419
78b.b18x3 4.23625458
79b.b18x5 4.595405
80b.l18x1 5.660836136
81b.b19x2 6.32656
82b.l19x1 5.655419
83b.l19x2 5.40875409
84b.b20x4 9.994558
85b.b20x6 7.325656
86b.b21x1 7.115457
87b.b21x3 6.7375456
88b.b21x5 4.4575474
89b.b21x7 5.56643775
90b.l21x2 5.18125404
91b.l21x5 3.7474
92b.b22x5 3.7675137
93b.l22x5 7.124109
94b.b23x6 6.79583677
95b.l23x2 5.12375478
96b.b24x4 5.49476
97b.l24x2 4.28254106
98b.l25x3 6.746119
99b.l25x6 12.565418
100b.b26x3 3.965406
101b.l27x3 7.618754257
102b.l28x1 11.3271719
103b.l28x2 8.784119
104b.b28x3 3.361587
105b.b28x4 5.856254116
106b.b28x6 10.4254119
107G.HN.30 2.575407
108G.S1.01 3.96625416
109G.S1.02 4.59625445
110G.S1.04 3.3275447
111G.S1.05 5.4425409
112G.S1.06 4.02625448
113G.S1.07 3.47409
114G.S2.05 6.07375414
115G.S3.02 7.3625414
116G.S3.04 4.776516
117G.S3.05 4.22167646
118G.S3.06 9.38416
119G.H2.04 4.40125409
120G.H2.06 5.01333619
121G.H2.07 4.48167619
122G.h2s4.01 6.59625419
123G.S4.02 4.613517
124G.s4h3.03 4.80875437
125G.s4h3.04 4.23812838
126G.H3.01 5.20875439
127G.H3.03 3.615434
128G.H3.09 5.07583639
129G.H3.17 6.93167614
130G.H3.18 4.975419
131G.S5.04 4.46439
132G.S5.05 3.535749
133G.S5.07 4.825449
134G.HG.04 4.7325278
135G.hgh4.01 4.06125434
136G.hgh4.02 4.74429737
137G.H4.05 2.9375284
138G.H4.15 5.30625438
139G.h4s6.11 3.4125407
140G.S6.02 4.8575207
141G.s6h5.01 5.73125449
142G.s6h5.05 4.2775449
143G.H5.03 5.585448
144G.H5.08 5.711254198
145G.H5.21 2.6325404
146G.H5.25 4.448507
147g.h2x11 8.81254136
148g.h2x15 5.5075406
149g.ctx3 5.368509
150g.ctx14 5.617509
151g.ctx16 4.591676248
152Lig 8.355421220
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
17x39 7x42 11.76268.685YesYes067
23x36 6x48 15.06886.21NoYes268
33x36 Lig 11.21678.72NoYes260
46x52 Lig 22.08885.925YesYes270
56x48 6x52 18.94147.02YesYes287
66x44 6x48 33.15015.015YesYes298
75x54 6x44 56.96295.6YesYes289
85x54 5x58 56.24284.19YesYes289
93x50 5x58 57.79743.6YesYes099
103x46 3x50 62.01164.385NoYes099
112x42 3x46 62.14053.77YesNo089
122x42 3x49 69.13614.18YesYes089
132x39 3x49 72.70223.475YesYes1489
142x37 2x39 77.75433.845NoYes078
152x37 2x40 77.86967.31NoYes079
165x47 6x52 18.3921.97YesYes277
175x47 6x44 22.73847.505YesYes279
182x40 I1x50 72.94814.805YesYes1798
191x60 I1x50 99.23685.23NoYes068
201x60 8x56 99.31575.2NoNo064
218x56 b.l25x4 99.5469.53NoNo045
22b.l25x4 b.l28x2 99.6267.315NoYes059
238x49 I1x50 12.63873.39NoYes068
248x47 8x50 16.92714.945NoYes088
258x47 8x48 28.74193.33NoNo086
268x48 G.H5.21 28.35762.71NoYes064
27G.H5.21 G.H5.26 27.20334.345YesNo045
28G.H5.17 G.H5.26 25.28436.825NoNo055
29G.H5.17 G.S6.02 24.11692.985NoYes2057
30G.H5.13 G.S6.02 22.97874.6NoYes077
315x68 G.H5.13 21.82385.305NoNo077
325x68 G.H5.16 21.43456.355NoNo076
33G.H5.16 I2x50 21.04483.32NoNo068
34I2x50 I2x51 20.65493.61NoYes086
35G.S3.01 I2x51 16.740312.515NoYes046
36b.l25x3 b.l28x2 1008.82YesYes1199
37b.b27x3 b.l25x3 79.75244.11NoYes089
38b.b26x3 b.b27x3 59.57543.685YesNo068
39b.b22x2 b.b26x3 81.5866.005NoYes086
40b.b22x1 b.b22x2 81.55462.4NoNo088
41b.b22x1 b.l23x1 81.52294.34NoNo086
42b.l23x1 b.l25x6 81.458620.25NoYes068
43G.H3.17 b.l25x6 76.7235YesYes148
44G.H3.15 G.H3.17 76.94933.39NoYes184
45G.H2.08 G.H3.15 62.67192.835NoNo188
46G.H2.04 G.H2.08 62.70333.13YesNo098
47G.H2.04 G.H2.07 69.01345YesYes099
48G.H2.07 b.l9x6 78.94083.86YesYes198
49G.H2.06 b.l9x6 63.20512.985YesYes198
50G.H2.06 b.l17x6 31.37727.605YesYes199
51b.l17x5 b.l17x6 31.34412.945NoYes169
52b.l17x5 b.l19x2 62.24942.945NoYes069
53b.b19x6 b.l19x2 32.98352.945NoYes099
54b.b19x6 b.l17x3 32.631212.55NoYes099
55b.b20x6 b.l17x3 24.58715.09YesYes569
56b.b17x7 b.b20x6 27.17239.65YesYes586
57b.b17x7 b.b21x1 25.1184.78YesYes587
58b.1x19 b.b21x1 22.921913.695NoYes067
59b.1x15 b.1x19 19.97041.255NoNo076
60b.1x11 b.1x15 16.27461.425NoNo087
61b.1x11 g.h1x12 13.31292.82NoNo086
62g.h1x12 g.h1x9 12.57173.375NoNo066
63g.h1x5 g.h1x9 11.83034.07NoNo066
64b.1x4 g.h1x5 11.08863.645NoNo086
65G.H2.06 b.l19x1 31.37873.455YesYes199
66b.l17x5 b.l19x1 31.24744.415NoYes169
67b.b20x2 b.l19x2 28.5817.95NoYes069
68b.b20x2 b.b20x4 27.87166.47NoYes068
69b.b20x4 b.b20x6 24.5864.275YesYes586
70b.b27x3 b.b28x6 21.52178.49NoYes089
71b.b25x7 b.b28x6 41.963318.79NoYes079
72b.b25x7 b.lhb1x11 63.8826.36NoYes074
73b.b28x7 b.lhb1x11 58.02253.505NoYes094
74b.b28x7 g.ctx14 56.00347.49NoYes099
75g.ctx14 g.ctx15 49.90545.705YesNo099
76b.l27x5 g.ctx15 46.81024.195NoNo059
77b.l27x5 g.ctx4 34.11686.705NoNo057
78g.ctx3 g.ctx4 33.85074.025YesNo097
79b.l22x3 g.ctx3 33.18366.625NoYes099
80b.l22x3 g.h2x15 32.91133.485NoYes096
81g.h2x11 g.h2x15 32.092511.43YesYes066
82b.l18x1 g.h2x11 15.33094.645YesYes1366
83b.b22x5 b.l18x1 14.25054.825YesYes1376
84b.b22x5 b.b23x2 25.56154.87YesNo076
85b.b21x7 b.b23x2 24.98677.035YesNo056
86b.b28x4 b.l25x3 21.5658.515YesYes1169
87b.b28x4 b.b28x6 21.67112.9YesYes1169
88b.l18x2 g.h2x11 14.46413.475NoYes1376
89b.b22x5 b.l18x2 14.18082.885YesNo1377
90b.l27x3 b.l27x5 14.29679.705YesNo075
91b.l27x1 b.l27x3 13.11697.95NoYes2587
92b.b2x5 b.l27x1 12.836810.31YesNo078
93b.b2x5 b.b3x2 11.369911.39YesNo075
94b.b3x2 b.b4x6 11.07573.42NoYes059
95b.b10x1 b.l9x6 16.63644.45NoYes098
96b.b10x1 b.b11x5 16.4253.26NoNo096
97b.b11x5 b.l13x7 15.78924.04NoNo069
98b.b15x3 b.l13x7 13.12983.235NoNo099
99b.b15x3 b.b16x6 12.70026.18NoYes098
100b.b13x7 b.b16x6 11.680812.53YesYes1278
101b.b13x5 b.b13x7 11.04145.84NoYes047
102b.b12x5 b.b13x5 10.60393.685NoNo064
103b.b11x1 b.b12x5 10.38475.325NoNo056
104b.l11x1 b.l9x6 11.70815.07NoYes098
105b.b11x6 b.l11x1 11.49013.71NoNo099
106b.b19x2 b.b20x6 21.352911.255YesYes566
107b.b15x2 b.b19x2 11.86818.525YesYes566
108b.b15x2 b.b16x5 11.10512.98YesNo065
109b.b16x5 b.l14x6 16.67182.075NoNo053
110b.b16x7 b.l14x6 14.82053.39YesNo093
111b.b21x7 b.b24x6 10.516312.54YesNo758
112b.b24x3 b.b26x3 22.45553.17NoYes056
113G.S3.01 G.S3.03 15.56036.7NoNo047
114G.S2.06 G.S3.03 12.371712.325NoNo087
115G.S2.06 G.S3.05 11.57614.355NoYes486
116G.H3.15 G.H3.18 14.2344.83NoYes189
117G.H3.18 G.S4.02 13.37976.91YesYes197
118G.S4.02 G.S5.02 14.23724.415YesNo075
119G.H3.09 G.S5.02 11.89033.765YesNo095
120G.H3.09 G.H4.15 16.73794.825YesYes398
121G.H3.06 G.H4.15 15.96464.975NoYes368
122G.H3.06 G.hgh4.02 13.43634.19NoYes367
1238x50 I1x50 13.827610.355YesYes1788
1248x47 8x49 12.20436.985NoNo086
125b.b24x3 b.b25x7 22.1617.94NoNo057
126G.H3.09 G.S4.04 13.672410.185YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x284.8452NoYes7621
2x563x327.152NoYes7721
2x567x423.712NoYes7721
2x593x286.590NoYes4621
2x603x284.6550NoYes6621
3x28E1x505.7050YesYes6712
3x28Lig3.240YesYes6010
3x29E2x523.370NoNo6421
3x323x362.972YesNo7611
3x327x4210.3452YesYes7711
3x32Lig14.3052YesYes7010
3x33Lig8.470NoYes6010
3x366x486.212NoYes6812
3x36Lig8.722NoYes6010
3x375x4617.990NoNo6621
E2E248.4252YesYes3322
E2E2x523.82YesNo3421
5x39E26.142YesYes7322
E2x52Lig10.032NoYes4010
5x395x4310.1752YesNo7621
5x43Lig5.490NoYes6010
5x446x555.5252NoNo6621
5x4616x523.9652NoYes6711
5x461Lig4.862NoYes6010
5x476x484.512YesYes7822
5x476x5221.972YesYes7721
6x486x527.022YesYes8721
6x516x526.432YesYes7711
6x517x347.52YesNo7412
6x517x372.682YesYes7512
6x517x3810.932YesNo7611
6x51Lig10.3552YesYes7010
6x52Lig5.9252YesYes7010
6x55Lig7.990NoYes6010
7x387x4213.6152NoYes6711
7x38Lig15.1852NoYes6010
7x397x428.6850YesYes6721
7x42Lig5.6952YesYes7010
2x607x423.8150NoYes6721
5x406x556.650NoNo6621

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
100.00Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
100.00Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
100.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
100.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
100.00Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
92.31Single6H7JIsoprenaline6H7J-β1-Isoprenaline
92.31Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
91.67Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
91.67Single6H7MSalbutamol6H7M-β1-Salbutamol
91.67Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
91.67Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
91.67Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
91.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
91.67Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
91.67Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
91.67Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8GGJEpinephrine8GGJ-β2-Epinephrine
91.67Single8GGNEpinephrine8GGN-β2-Epinephrine
91.67Single8GGOEpinephrine8GGO-β2-Epinephrine
91.67Single8GGUEpinephrine8GGU-β2-Epinephrine
91.67Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
91.67Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
91.67Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
85.71Single4AMIBucindolol4AMI-β1-Bucindolol
85.71Single4LDEBI1671074LDE-β2-BI167107
85.71Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
85.71Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
85.71Single8JJ8Formoterol8JJ8-β2-Formoterol
84.62Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
84.62Single2Y03Isoprenaline2Y03-β1-Isoprenaline
84.62Single6E67BI1671076E67-β2-BI167107-Gs (fused)
84.62Single7WC6LSD7WC6-5-HT2A-LSD
84.62Single7XKAEpinephrine7XKA-β2-Epinephrine
84.62Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
84.62Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
84.62Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
84.62Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
84.62Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
84.62Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
84.62Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
83.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
83.33Single6PS4ICI 118-5516PS4-β2-ICI 118-551
83.33Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
83.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
83.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
83.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
83.33Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
83.33Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8GGIEpinephrine8GGI-β2-Epinephrine
83.33Single8GGKEpinephrine8GGK-β2-Epinephrine
83.33Single8GGMEpinephrine8GGM-β2-Epinephrine
83.33Single8GGPEpinephrine8GGP-β2-Epinephrine
83.33Single8GGQEpinephrine8GGQ-β2-Epinephrine
83.33Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
80.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
80.00Single6H7LDobutamine6H7L-β1-Dobutamine
80.00Single6IBLArformoterol6IBL-β1-Arformoterol
78.57Single3P0GBI1671073P0G-β2-BI167107
78.57Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
78.57Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
78.57Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
78.57Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
78.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
78.57Single6WGTLSD6WGT-5-HT2A-LSD
78.57Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
78.57Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
78.57Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
78.57Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
78.57Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
78.57Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
78.57Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
78.57Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
78.57Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
76.92Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
76.92Single2Y02Carmoterol2Y02-β1-Carmoterol
76.92Single2Y04Salbutamol2Y04-β1-Salbutamol
76.92Single3NY8ICI 118-5513NY8-β2-ICI 118-551
76.92Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
76.92Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
76.92Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
76.92Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
76.92Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
76.92Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
76.92Single6PS1Timolol6PS1-β2-Timolol
76.92Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
76.92Single7BU7BI1671077BU7-β1-BI167107
76.92Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
76.92Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
76.92Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
76.92Single7WC7Lisuride7WC7-5-HT2A-Lisuride
76.92Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
76.92Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
76.92Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
76.92Single8JJOAlprenolol8JJO-β2-Alprenolol
76.92Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
76.92Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
76.92Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
76.92Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
76.92Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
76.92Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
76.92Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
76.92Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
75.00Single6KUXRS-799486KUX-α2a-RS-79948
75.00Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
75.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
75.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
75.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
75.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
75.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
75.00Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8GGVEpinephrine8GGV-β2-Epinephrine
75.00Single8GGWEpinephrine8GGW-β2-Epinephrine
75.00Single8GGXEpinephrine8GGX-β2-Epinephrine
75.00Single8GH0Epinephrine8GH0-β2-Epinephrine
75.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
75.00Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
75.00Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
75.00Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
73.33Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
73.33Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
73.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
73.33Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
73.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
73.33Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
73.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
73.33Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
73.33Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
73.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
71.43Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
71.43Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
71.43Single5TVNLSD5TVN-5-HT2B-LSD
71.43Single5WIUNemonapride5WIU-D4-Nemonapride
71.43Single5WIVNemonapride5WIV-D4-Nemonapride-Na
71.43Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
71.43Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
71.43Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
71.43Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
71.43Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
71.43Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
71.43Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
71.43Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
71.43Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
70.59Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
70.59Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
69.23Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
69.23Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
69.23Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
69.23Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
69.23Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
69.23Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Single8GGLEpinephrine8GGL-β2-Epinephrine
69.23Single8GGTEpinephrine8GGT-β2-Epinephrine
69.23Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
69.23Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
69.23Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
69.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
69.23Consensus5ht5_onOrthosteric Ligand5ht5a_on
69.23Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
69.23Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
69.23Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
68.75Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
68.75Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
68.75Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Single2YDVNECA2YDV-A2A-NECA
66.67Single3PBLEticlopride3PBL-D3-Eticlopride
66.67Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
66.67Single4UHRCGS216804UHR-A2A-CGS21680
66.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
66.67Single5G53NECA5G53-A2A-NECA-Gs
66.67Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
66.67Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
66.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
66.67Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
66.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
66.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
66.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
66.67Single8GGSEpinephrine8GGS-β2-Epinephrine
66.67Single8GGYEpinephrine8GGY-β2-Epinephrine
66.67Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
66.67Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
66.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
66.67Consensus5ht5_offOrthosteric Ligand5ht5a_off
66.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
66.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
66.67Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
66.67Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
66.67Consensushistamine_offOrthosteric Ligandh1_off
64.71Single3NY9PubChem 9131033NY9-β2-PubChem 913103
64.71Single8X5YAstemizole8X5Y-H1-Astemizole
64.29Single2Y01Dobutamine2Y01-β1-Dobutamine
64.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
64.29Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
64.29Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
64.29Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
64.29Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
64.29Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
64.29Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
64.29Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
64.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
64.29Single8X64Desloratadine8X64-H1-Desloratadine
64.29Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
64.29Consensustar_onOrthosteric Ligandta1_on
62.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
62.50Single6MXTSalmeterol6MXT-β2-Salmeterol
62.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
62.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
62.50Single8JJLOlodaterol8JJL-β2-Olodaterol
61.54Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
61.54Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
61.54Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
61.54Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
61.54Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
61.54Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
61.54Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
61.54Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
61.54Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
61.54Consensusalpha1_onOrthosteric Ligandalpha1a_on
61.54Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.54Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
61.54Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.11Single4IARErgotamine4IAR-5-HT1B-Ergotamine
60.00Single2Y00Dobutamine2Y00-β1-Dobutamine
60.00Single5C1MBU725C1M-μ-BU72
60.00Single6PS6Timolol6PS6-β2-Timolol
60.00Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
60.00Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
60.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
60.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
60.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
60.00Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
60.00Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
60.00Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
58.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
58.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
58.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
58.82Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
58.82Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.82Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
58.82Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
58.33Single8GGREpinephrine8GGR-β2-Epinephrine
58.33Single8GGZEpinephrine8GGZ-β2-Epinephrine
58.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
57.14Single6A94Zotepine6A94-5-HT2A-Zotepine
57.14Single6TPGEMPA6TPG-OX2-EMPA
57.14Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
57.14Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
57.14Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
57.14Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
57.14Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
57.14Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
57.14Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
57.14Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
57.14Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
57.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
57.14Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
57.14Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
56.25Single4RWADIPP-NH24RWA-δ-DIPP-NH2
56.25Single4U15Tiotropium4U15-M3-Tiotropium
56.25Single6J21Aprepitant6J21-NK1-Aprepitant
56.25Single6OL9Tiotropium6OL9-M5-Tiotropium
56.25Single6TQ7SB-3348676TQ7-OX1-SB-334867
56.25Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
56.25Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
56.25Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
56.25Single8E0GBU728E0G-μ-BU72
56.25Consensusa2_onOrthosteric Liganda2a_on a2b_on
56.25Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
56.25Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
56.25Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
55.56Single4UG2CGS216804UG2-A2A-CGS21680
55.56Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
53.85Single7SRQLSD7SRQ-5-HT2B-LSD
53.85Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.85Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
53.85Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
53.85Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.85Single8GH1Epinephrine8GH1-β2-Epinephrine
53.85Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
53.85Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
53.85Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.85Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
53.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
53.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.33Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
53.33Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
53.33Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
53.33Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
53.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
53.33Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
53.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
53.33Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
53.33Single7UL4Alvimopan7UL4-μ-Alvimopan
53.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
53.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
53.33Single8X63Mepyramine8X63-H1-Mepyramine
53.33Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
53.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
53.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
53.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.33Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
53.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
53.33Consensushistamine_onOrthosteric Ligandh1_on h4_on
52.94Single5CXVTiotropium5CXV-M1-Tiotropium
52.94Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
52.94Single7YITNalfurafine7YIT-κ-Nalfurafine
52.94Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
52.94Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
52.94Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
52.94Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
52.94Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
52.94Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
52.63Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
52.38Single7C61Ergotamine7C61-5-HT1B-Ergotamine
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5WQCEMPA5WQC-OX2-EMPA
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
50.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
50.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
50.00Single6HLOAprepitant6HLO-NK1-Aprepitant
50.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
50.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single6TP6Filorexant6TP6-OX1-Filorexant
50.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
50.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
50.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
50.00Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
50.00Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8IWESpermidine8IWE-TAAR9-Spermidine
50.00Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
50.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
50.00Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
50.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Single6PT3DPI-2876PT3-δ-DPI-287
47.06Single4DJHJDTic4DJH-κ-JDTic
47.06Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
47.06Single5V54Methiothepin5V54-5-HT1B-Methiothepin
47.06Single5X93K-87945X93-ETB-K-8794
47.06Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
47.06Single6J20Aprepitant6J20-NK1-Aprepitant
47.06Single7B6WCyclazosin7B6W-α1b-Cyclazosin
47.06Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
47.06Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
47.06Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
47.06Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.06Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
47.06Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
47.06Consensus5ht1_offOrthosteric Ligand5ht1b_off
47.06Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
47.06Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
47.06Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
47.06Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
47.06Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
46.67Single2YDOAdenosine2YDO-A2A-Adenosine
46.67Single3RZECidoxepin3RZE-H1-Cidoxepin
46.67Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
46.67Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
46.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
46.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
46.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
46.67Single6TPNHTL66416TPN-OX2-HTL6641
46.67Single6VI4JDTic6VI4-κ-JDTic
46.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
46.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
46.67Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
46.67Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
46.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
46.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
46.67Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
46.67Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
46.67Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
46.67Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
46.67Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
46.15Single3UZAGTPL92363UZA-A2A-GTPL9236
46.15Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
46.15Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
46.15Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
45.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
44.44Single6CM4Risperidone6CM4-D2-Risperidone
44.44Single6HLPNetupitant6HLP-NK1-Netupitant
44.44Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
44.44Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
44.44Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
43.75Single4DAJTiotropium4DAJ-M3-Tiotropium
43.75Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
43.75Single4MQSIperoxo4MQS-M2-Iperoxo
43.75Single4U14Tiotropium4U14-M3-Tiotropium
43.75Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
43.75Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
43.75Single5DSGTiotropium5DSG-M4-Tiotropium
43.75Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
43.75Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
43.75Single6DRXLisuride6DRX-5-HT2B-Lisuride
43.75Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
43.75Single6TOTLemborexant6TOT-OX1-Lemborexant
43.75Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
43.75Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
43.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
43.75Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
43.75Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
43.75Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
43.75Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
43.75Consensusadenosine_onOrthosteric Liganda1_on a2_on
43.75Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
43.75Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
43.75Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
43.75Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
43.75Consensusnucleotide_onOrthosteric Ligandadenosine_on
43.75Consensustachykinin_offOrthosteric Ligandnk1_off
43.48Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
42.86Single3QAKUK-4320973QAK-A2A-UK-432097
42.86Single6HLLCP999946HLL-NK1-CP99994
42.86Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
42.86Single6TP4ACT-4622066TP4-OX1-ACT-462206
42.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
42.86Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
42.86Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
42.11Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.11Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.11Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
42.11Single7EZCUKA7EZC-A2A-UKA
42.11Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
42.11Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
42.11Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
42.11Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
41.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.67Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
41.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
41.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
41.18Single5XPRBosentan5XPR-ETB-Bosentan
41.18Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
41.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
41.18Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
41.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
41.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
41.18Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
41.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
41.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
41.18Single8EA0Iperoxo8EA0-M3-Iperoxo
41.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
41.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
41.18Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
41.18Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
40.91Single5WF5UK-4320975WF5-A2A-UK-432097
40.91Single6PT2KGCHM076PT2-δ-KGCHM07
40.91Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
40.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
40.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
40.00Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
40.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
40.00Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
40.00Single5DHHSB-6121115DHH-NOP-SB-612111
40.00Single5WF6UK-4320975WF6-A2A-UK-432097
40.00Single5WS3EMPA5WS3-OX2-EMPA
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6B73PubChem 1319551386B73-κ-PubChem 131955138
40.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
40.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
40.00Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
40.00Single7SK9CCX6627SK9-ACKR3-CCX662
40.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
40.00Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
40.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
40.00Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
40.00Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
38.89Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
38.89Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
38.89Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
38.89Single6E59L-7607356E59-NK1-L-760735
38.89Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
38.89Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
38.89Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
38.89Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
38.89Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
38.89Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
38.89Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
38.89Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
38.89Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
38.89Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
38.89Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
38.89Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.89Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
38.89Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
38.46Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
38.46Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
38.46Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
38.46Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
38.46Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
38.46Consensussensory_onOrthosteric Ligandopsin_on
38.10Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
38.10Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
38.10Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.10Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
38.10Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
38.10Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
37.50Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
37.50Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
37.50Single6IQLL7458706IQL-D4-L745870
37.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
37.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
37.50Single6TP3Nemorexant6TP3-OX1-Nemorexant
37.50Single6V9SGTPL114036V9S-OX1-GTPL11403
37.50Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
37.50Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
37.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
37.50Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
37.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
37.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
37.50Consensussensory_offOrthosteric Ligandopsin_off
36.84Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
36.84Single6A93Risperidone6A93-5-HT2A-Risperidone
36.84Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
36.84Single6ZG4HTL00099366ZG4-M1-HTL0009936
36.84Single7DFPSpiperone7DFP-D2-Spiperone
36.84Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
36.84Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.84Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
36.84Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
36.84Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
36.84Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
36.84Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
36.84Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
36.84Consensusgs_steroidOrthosteric Ligandgs_bileacid
36.84Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.84Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
36.84Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.36Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
36.36Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
35.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
35.71Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
35.71Single7WC5Psilocin7WC5-5-HT2A-Psilocin
35.71Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
35.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
35.71Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
35.29Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
35.29Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
35.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
35.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
35.29Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
35.29Single8CU6LJ-45178CU6-A2A-LJ-4517
35.29Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.29Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
35.29Consensusgi_hcarOrthosteric Ligandgi_hca
35.29Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
35.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
35.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
35.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
35.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
35.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
35.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
35.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
35.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
35.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
35.00Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.00Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
35.00Consensusorexin_onOrthosteric Ligandox2_on
35.00Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.00Consensussteroid_onOrthosteric Ligandbileacid_on
34.78Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
34.78Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
34.78Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
33.33Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
33.33Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
33.33Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
33.33Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
33.33Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
33.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
33.33Single5NM2ZM2413855NM2-A2A-ZM241385-Na
33.33Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
33.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
33.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
33.33Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
33.33Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
33.33Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
33.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
33.33Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
33.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
33.33Consensuslpl_onOrthosteric Ligands1p_on lpa_on
33.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
33.33Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.14Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
32.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
32.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
32.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
32.00Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
31.82Single7F8XNN90567F8X-CCKA-NN9056
31.82Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.82Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
31.82Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
31.82Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
31.82Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
31.82Consensussst_onOrthosteric Ligandsst2_on sst4_on
31.58Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
31.58Single7EPENAM5637EPE-mGlu-NAM563
31.58Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.58Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
31.58Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
31.58Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.58Single7W41PD1762527W41-BB2-PD176252
31.58Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.58Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
31.58Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
31.58Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.58Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
31.58Consensusadenosine_offOrthosteric Liganda1_off a2_off
31.58Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
31.58Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
31.58Consensusbombesin_offOrthosteric Ligandbb2_off
31.58Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
31.58Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
31.58Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
31.58Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
31.58Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
31.58Consensuslpa_offOrthosteric Ligandlpa1_off
31.58Consensuslpa_onOrthosteric Ligandlpa1_on
31.58Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
31.25Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
31.25Single4S0VSuvorexant4S0V-OX2-Suvorexant
31.25Single5K2DZM2413855K2D-A2A-ZM241385
31.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
31.25Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
31.25Single6JZHZM2413856JZH-A2A-ZM241385-Na
31.25Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25Single6PS7ZM2413856PS7-A2A-ZM241385-Na
31.25Single6TPJSuvorexant6TPJ-OX2-Suvorexant
31.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.25Single7F8ULintitript7F8U-CCKA-Lintitript
31.25Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
31.25Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
31.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
31.25Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
31.25Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
31.25Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
31.25Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.25Single8GNGIstradefylline8GNG-A2A-Istradefylline
31.25Single8IHKAcifran8IHK-HCA3-Acifran
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
31.25Consensusgt_class-aOrthosteric Ligandgt_opsin
31.25Consensusgt_opsinOrthosteric Ligandgt_sensory
31.25Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
31.25Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
30.77Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
30.77Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
30.77Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
30.77Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
30.77Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.77Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Single8PWNTheophylline8PWN-A2A-Theophylline
30.77Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
30.77Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
30.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.43Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
30.43Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
30.43Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
30.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
30.43Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
30.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
30.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
30.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
30.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
30.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
30.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
30.00Single8WU1KCA8WU1-CB1-KCA-Arrestin1
30.00Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
30.00Consensusgi_class-fOther Ligandgi_frizzled
30.00Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
30.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
30.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
30.00Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
29.63Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
29.41Single3REYPubChem 56973REY-A2A-PubChem 5697
29.41Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.41Single5IU4ZM2413855IU4-A2A-ZM241385-Na
29.41Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.41Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.41Single5JTBZM2413855JTB-A2A-ZM241385
29.41Single5K2BZM2413855K2B-A2A-ZM241385-Na
29.41Single5K2CZM2413855K2C-A2A-ZM241385-Na
29.41Single5NLXZM2413855NLX-A2A-ZM241385-Na
29.41Single5NM4ZM2413855NM4-A2A-ZM241385-Na
29.41Single6AQFZM2413856AQF-A2A-ZM241385
29.41Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.41Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
29.41Single7AROLUF58337ARO-A2A-LUF5833-Na
29.41Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
29.41Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
29.41Single7T32ZM2413857T32-A2A-ZM241385
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
29.41Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
29.41Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
29.41Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
29.41Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
29.41Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
29.41Single8K5CAcipimox8K5C-HCA2-Acipimox
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
29.41Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
29.41Consensushca_onOrthosteric Ligandhca2_on hca3_on
29.41Consensushcar_onOrthosteric Ligandhca_on
29.41Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
29.41Consensuss1p_offOrthosteric Ligands1p1_off
29.17Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
29.17Consensusangiotensin_onOrthosteric Ligandat1_on
29.17Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
29.17Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.03Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single3RFMCaffeine3RFM-A2A-Caffeine
28.57Single6K1QIRL25006K1Q-ETB-IRL2500
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
28.57Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
28.57Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
28.57Single8A2OTheophylline8A2O-A2A-Theophylline-Na
28.57Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
28.57Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
28.57Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
28.57Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
28.57Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
28.57Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
28.57Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
28.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
28.57Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
28.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
28.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
27.78Single3EMLZM2413853EML-A2A-ZM241385
27.78Single4EIYZM2413854EIY-A2A-ZM241385-Na
27.78Single4YAYZD-71554YAY-AT1-ZD-7155
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.78Single5K2AZM2413855K2A-A2A-ZM241385-Na
27.78Single5OLGZM2413855OLG-A2A-ZM241385-Na
27.78Single5UENDU1725UEN-A1-DU172
27.78Single5VRAZM2413855VRA-A2A-ZM241385-Na
27.78Single6LPJZM2413856LPJ-A2A-ZM241385-Na
27.78Single6LPKZM2413856LPK-A2A-ZM241385-Na
27.78Single6S0LZM2413856S0L-A2A-ZM241385
27.78Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
27.78Single7PYRPSB-21157PYR-A2A-PSB-2115
27.78Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
27.78Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.78Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.78Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
27.78Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
27.78Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
27.78Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
27.78Single8K5DGSK2560738K5D-HCA2-GSK256073
27.78Consensusa2_offOrthosteric Liganda2a_off
27.78Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
27.78Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensusblt_onOrthosteric Ligandblt1_on
27.78Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
27.78Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
27.78Consensusleuko_onOrthosteric Ligandblt_on
27.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.27Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
27.27Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
27.27Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
27.27Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
27.27Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
27.27Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
26.92Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
26.92Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
26.92Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.92Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.67Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
26.67Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
26.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
26.67Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
26.67Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
26.67Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
26.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
26.32Single5CGCHTL142425CGC-mGlu5-HTL14242
26.32Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.32Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
26.32Single5N2SPSB365N2S-A1-PSB36
26.32Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
26.32Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.32Single6LPLZM2413856LPL-A2A-ZM241385-Na
26.32Single6S0QZM2413856S0Q-A2A-ZM241385
26.32Single6WQAZM2413856WQA-A2A-ZM241385-Na
26.32Single7C4SS1P7C4S-S1P3-S1P
26.32Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
26.32Single7RM5ZM2413857RM5-A2A-ZM241385-Na
26.32Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
26.32Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
26.32Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.32Single8FYNZM2413858FYN-A2A-ZM241385-Na
26.32Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.32Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
26.32Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
26.32Single8QOTNanobody E8QOT-μ-Nanobody E
26.32Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.32Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
26.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.09Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
26.09Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
26.09Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
26.09Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.09Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
26.09Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.93Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
25.93Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
25.81Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
25.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single5XR8AM8415XR8-CB1-AM841
25.00Single5XRAAM115425XRA-CB1-AM11542
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
25.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
25.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
25.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
25.00Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
25.00Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
25.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
25.00Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.00Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
25.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
25.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
25.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
25.00Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
25.00Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
24.14Single6IGLIRL16206IGL-ETB-IRL1620
24.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
24.14Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
24.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
24.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
24.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
24.00Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Single4N4WSANT-14N4W-SMO-SANT-1
23.81Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
23.81Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
23.81Consensusblt_offOrthosteric Ligandblt1_off
23.81Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
23.81Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.81Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
23.81Consensusdp_offOrthosteric Liganddp2_off
23.81Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
23.81Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
23.81Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
23.53Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
23.53Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
23.53Single3PWHZM2413853PWH-A2A-ZM241385
23.53Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
23.53Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
23.53Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
23.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
23.53Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
23.53Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
23.53Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
23.53Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.53Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
23.53Consensusmglu_onOther Ligandmglu2_on mglu4_on
23.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.08Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
23.08Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
23.08Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.08Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
23.08Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
23.08Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
23.08Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
23.08Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
22.73Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
22.73Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
22.73Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
22.73Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
22.73Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
22.73Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
22.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.58Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.22Single5UVIZM2413855UVI-A2A-ZM241385
22.22Single6MH8ZM2413856MH8-A2A-ZM241385
22.22Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
22.22Single6TPKRetosiban6TPK-OT-Retosiban
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
22.22Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
22.22Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
22.22Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
22.22Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
22.22Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.22Consensusvasopressin-ot_offOrthosteric Ligandot_off
21.74Single5EE7MK08935EE7-Glucagon-MK0893
21.74Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
21.74Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
21.74Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
21.74Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
21.74Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
21.74Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
21.74Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.74Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
21.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.43Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
21.43Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
21.43Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
21.43Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.05Single5TGZAM65385TGZ-CB1-AM6538
21.05Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6GPSMK08126GPS-CCR2-MK0812
21.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
21.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
21.05Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
21.05Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
21.05Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
21.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
21.05Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
21.05Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.05Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
21.05Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
20.83Consensusclass-d_offOrthosteric Ligandste2_off
20.83Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
20.83Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
20.83Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.69Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.69Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.69Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
20.69Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.69Consensusgo_class-b1Orthosteric Ligandgo_crf
20.69Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
20.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
20.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
20.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
20.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
20.00Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
20.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
20.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
20.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
20.00Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
20.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
19.35Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
19.35Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
19.23Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
19.23Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
19.23Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
19.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
19.05Single7P2L4YI7P2L-mGlu5-4YI
19.05Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
19.05Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
19.05Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
19.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
19.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
19.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
19.05Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
19.05Consensuschemerin_onOrthosteric Ligandcml1_on
19.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
19.05Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.75Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
18.75Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.75Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
18.75Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.75Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
18.75Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.52Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
18.52Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
18.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
18.52Consensusgi_class-dOrthosteric Ligandgi_ste
18.52Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
18.18Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
18.18Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
18.18Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
18.18Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
18.18Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
18.18Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
18.18Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
18.18Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
18.18Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
18.18Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
18.18Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
18.18Consensusclass-b2_onOrthosteric Ligandadgrg_on
18.18Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
18.18Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
18.18Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
17.86Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.86Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
17.86Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
17.86Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
17.86Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
17.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
17.86Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.65Single3OE9IT1t3OE9-CXCR4-IT1t
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.65Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
17.65Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
17.65Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
17.65Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
17.65Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
17.39Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
17.39Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
17.39Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
17.39Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
17.39Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
17.24Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
17.24Consensusclass-d_onOrthosteric Ligandste2_on
17.14Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.67Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
16.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
16.67Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67Consensusclass-d_offOrthosteric Ligandste2_off
16.67Consensusgi_class-dOrthosteric Ligandgi_ste
16.67Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
16.67Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.67Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
16.22Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
16.22Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.13Single6LMLGlucagon6LML-Glucagon-Glucagon
16.13Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.13Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
16.13Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.13Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
16.00Single4XT1Fractalkine4XT1-US28-Fractalkine
16.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
16.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
16.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
16.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
16.00Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.79Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.79Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
15.79Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
15.79Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
15.79Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
15.79Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
15.79Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
15.79Consensusgnrh_offOrthosteric Ligandgnrh1_off
15.62Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
15.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
15.62Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
15.38Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
15.38Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
15.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
15.38Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
15.15Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.15Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
15.15Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
15.15Consensusglp_onOrthosteric Ligandglp1_on glp2_on
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single6FFHFenobam6FFH-mGlu5-Fenobam
15.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.00Single6IIVDaltroban6IIV-TP-Daltroban
15.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
15.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
15.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
15.00Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.00Consensushcar_offOrthosteric Ligandsuccinate_off
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
15.00Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
15.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
15.00Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
14.81Single3OE0CVX153OE0-CXCR4-CVX15
14.81Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
14.81Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
14.81Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
14.81Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
14.71Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
14.71Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
14.29Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
14.29Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.29Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
14.29Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
14.29Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
14.29Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
14.29Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.29Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
14.29Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
14.29Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.89Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.89Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
13.79Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
13.79Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
13.79Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
13.79Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
13.79Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
13.79Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
13.64Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
13.64Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
13.64Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.64Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.64Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.33Single4XT3Fractalkine4XT3-US28-Fractalkine
13.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.33Single6FJ3PTH6FJ3-PTH1-PTH
13.33Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
13.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.33Consensusclass-c_onOther Ligandgabab_on mglu_on
13.33Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.04Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.04Single6IIURamatroban6IIU-TP-Ramatroban
13.04Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
13.04Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
13.04Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
13.04Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.04Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
13.04Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
13.04Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
12.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.90Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.90Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
12.82Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.50Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
12.50Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
12.50Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
12.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
12.50Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
12.50Consensuscyslt_offOrthosteric Ligandcyslt2_off
12.50Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
12.50Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
12.50Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
12.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
12.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
12.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
12.00Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
12.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
12.00Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
11.76Single3OE6IT1t3OE6-CXCR4-IT1t
11.76Single3OE8IT1t3OE8-CXCR4-IT1t
11.76Single6LI0GTPL98046LI0-GPR52-GTPL9804
11.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
11.76Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
11.54Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
11.54Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
11.54Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
11.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Single5L7IVismodegib5L7I-SMO-Vismodegib
11.11Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
11.11Single7SK5CXCL127SK5-ACKR3-CXCL12
11.11Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensusclass-t_onOrthosteric Ligandtaste2_on
11.11Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.11Consensusgo_class-b2Orthosteric Ligandgo_adhesion
11.11Consensusgs_class-tOrthosteric Ligandgs_taste
11.11Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
11.11Consensussst_offOrthosteric Ligandsst2_off
11.11Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.81Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.71Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
10.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.71Single7XNACYN1548067XNA-SST2-CYN154806
10.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.71Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.53Single3ODUIT1t3ODU-CXCR4-IT1t
10.53Single5U09Taranabant5U09-CB1-Taranabant
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
10.53Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
10.53Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
10.34Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.34Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
10.34Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.34Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
10.26Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
10.00Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
9.68Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
9.68Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.68Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.68Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
9.68Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
9.68Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
9.52Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
9.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.52Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
9.52Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.38Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
9.38Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
9.38Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
9.09Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
9.09Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
9.09Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.09Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.09Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
9.09Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
9.09Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
8.82Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.82Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
8.82Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.70Single5TZR-5TZR-FFA1 (GPR40)-MK8666
8.70Single5V56TC1145V56-SMO-TC114
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
8.70Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
8.70Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single6OS2TRV0266OS2-AT1-TRV026
8.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
8.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
8.33Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
8.33Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensuschemokine_offOrthosteric Ligandcxcr_off
8.33Consensusclass-c_offOther Ligandgabab_off mglu_off
8.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
8.33Consensuscxcr_offOrthosteric Ligandcxcr4_off
8.33Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
8.33Consensusnts_offOrthosteric Ligandnts1_off
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.00Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
8.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
8.00Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.69Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
7.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
7.41Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
7.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
6.90Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
6.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
6.25Single7SK3CXCL127SK3-ACKR3-CXCL12
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.06Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.06Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
5.88Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
5.88Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
5.88Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.88Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
5.88Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
5.56Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
5.56Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
5.56Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.56Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
5.26Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.26Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.26Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.26Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.26Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.26Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.00Single7WV9ZCZ0117WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensuscb1_on_alloOther Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
5.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.76Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.76Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.76Single7VV6C48/807VV6-MRGPRX2-C48/80
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8IYXYL-3658IYX-GPR34-YL-365
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.76Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.76Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.76Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.55Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.55Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.35Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.35Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.35Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.17Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.17Single5V57TC1145V57-SMO-TC114
4.17Single6OS1TRV0266OS1-AT1-TRV026
4.17Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.17Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.00Consensusnts_onOrthosteric Ligandnts1_on
3.85Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
3.85Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.85Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
3.85Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.57Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.45Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
2.86Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.78Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.78Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.70Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.63Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.63Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.56Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.44Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.33Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.27Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.27Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.17Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

Consensus Members
Id Members
7S0F 7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
6K42 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
Net Summary
Imin 2.67
Number of Linked Nodes 857
Number of Links 1018
Number of Hubs 152
Number of Links mediated by Hubs 594
Number of Communities 29
Number of Nodes involved in Communities 219
Number of Links involved in Communities 306
Path Summary
Number Of Nodes in MetaPath 127
Number Of Links MetaPath 126
Number of Shortest Paths 1210725
Length Of Smallest Path 3
Average Path Length 32.0476
Length of Longest Path 61
Minimum Path Strength 0.73
Average Path Strength 5.73261
Maximum Path Strength 23.1825
Minimum Path Correlation 0.7
Average Path Correlation 0.974882
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.81818
Average % Of Corr. Nodes 37.9109
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.6316
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_aminegi_5ht
gi_adrenergic
gi_dopamine
gi_muscarinic
gi_histamine



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